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4. Dual Antiplatelet Therapy for 6 Versus 18 Months After Biodegradable Polymer Drug-Eluting Stent Implantation

Author

Okada, Hisayuki, Ito, Yoshiaki, Hara, Hidehiko, Ando, Kenji, Anzai, Hitoshi, Tanaka, Hiroyuki, Ueda, Yasunori, Takiuchi, Shin, Nishida, Yasunori, Ohira, Hiroshi, Kawaguchi, Katsuhiro, Kadotani, Makoto, Niinuma, Hiroyuki, Omiya, Kazuto, Morita, Takashi, Zen, Kan, Yaita, Yoshinori, Inoue, Kenji, Ishiwata, Sugao, Ochiai, Masahiko, Takamisawa, Itaru, Yajima, Junji, Ishihara, Takayuki, Nakamura, Shigeru, Fujii, Kenshi, Ashida, Kazuhiro, Ota, Hiroshi, Okutsu, Masaaki, Oshima, Masao, Kongoji, Ken, Jinno, Yasushi, Shutta, Ryu, Shiode, Nobuo, Oumi, Tetsuo, Doijiri, Tatsuki, Yokoi, Yoshiaki, Ogawa, Takayuki, Kimura, Keizo, Munemasa, Mitsuru, Mukawa, Hiroaki, Komiyama, Kota, Suzuki, Takeshi, Inoue, Takumi, Ueno, Takafumi, Sugano, Teruyasu, Yamashita, Jun, Yasumura, Yoshio, Kamiya, Haruo, Fujita, Hiroshi, Shinke, Toshiro, Urasawa, Kazushi, Ono, Shiro, Ajioka, Masayoshi, Ando, Jiro, Mizuno, Koichi, Hirayama, Haruo, Tojo, Taiki, Maekawa, Yuichiro, Kawasaki, Tomohiro, Okamura, Takayuki, Toyota, Fumitoshi, Hikichi, Yutaka, Michishita, Ichiro, Yagi, Takafumi, Kamihata, Hiroshi, Shindo, Naohisa, Ishizaka, Nobukazu, Ashikaga, Takashi, Ozaki, Yukio, Hara, Hisao, Sakamoto, Hiroshi, Kada, Kenji, Doi, Naofumi, Honye, Junko, Yokoi, Hiroyoshi, Takano, Hitoshi, Kawata, Masahito, Houzawa, Hidenori, Ozawa, Toru, Kikuchi, Arifumi, Kadota, Kazushige, Kijima, Yoichi, Ikemoto, Tomokazu, Shimada, Yoshihisa, Yumoto, Kazuhiko, Kawajiri, Kenji, Nozaki, Yoichi, Sakakibara, Masayoshi, Tosaka, Atsushi, Noma, Shigetaka, Wakabayashi, Yasushi, Okada, Masaharu, Hirose, Mizuki, Takagi, Yuichiro, Takagi, Takuro, Miyauchi, Katsumi, Misu, Kazuhiko, Yasuda, Satoshi, Yoshikawa, Ryohei, Inoue, Ichiro, Yoshiyama, Minoru, Masuyama, Toru, Tomobuchi, Yoshiaki, Yamazaki, Seiji, Tanabe, Kengo, Wagatsuma, Kenji, Kato, Masayuki, Kawai, Kazuya, Hamazaki, Yuji, Yamagishi, Masakazu, Shibata, Yoshisato, Watanabe, Kouki, Tachibana, Koichi, Wada, Hiroshi, Ninomiya, Kenji, Suzuki, Hiroshi, Yoshioka, Jiro, Mori, Chikara, Sonoda, Masahiro, Kataoka, Toru, Terai, Hidenobu, Onishi, Yuko, Toma, Masanao, Serikawa, Takeshi, Otsuka, Yoritaka, Yano, Shoji, Ebisawa, Soichiro, Takashima, Hiroaki, Shimomura, Hideki, Kurumatani, Yoko, Sonoda, Shinjo, Uehara, Hiroki, Nakamura, Masato, Iijima, Raisuke, Ako, Junya, Yasaka, Yoshinori, and Hamasaki, Toshimitsu

Published
2017
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6. Prevention of Contrast-Induced Nephropathy After Emergency Percutaneous Coronary Intervention With a Single Bolus Administration of High-Concentrate Sodium Bicarbonate ― Rationale and Design of a Single-Arm Study Compared With Historical Controls ―

Author

Nakamura, Takuya, primary, Watanabe, Makoto, additional, Nogi, Kazutaka, additional, Kosugi, Takaaki, additional, Hashimoto, Yukihiro, additional, Ueda, Tomoya, additional, Doi, Naofumi, additional, Kawata, Hiroyuki, additional, Horii, Manabu, additional, Ishigami, Kenichi, additional, Nakajima, Tamio, additional, Watabe, Hiroaki, additional, Abe, Daisuke, additional, Kuwahara, Koichiro, additional, Okumura, Yasuo, additional, Ozu, Naoki, additional, Suzuki, Shota, additional, Kasama, Shu, additional, and Saito, Yoshihiko, additional

Published
2023
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7. Reverse Remodeling and Non-Contrast T1 Hypointense Infarct Core in Patients With Reperfused Acute Myocardial Infarction

Author

Hashimoto, Yukihiro, primary, Soeda, Tsunenari, additional, Seno, Ayako, additional, Okayama, Satoshi, additional, Fukuda, Nozomi, additional, Yano, Hiroki, additional, Iwai, Atsushi, additional, Nogi, Kazutaka, additional, Hirai, Kaeko, additional, Fujimoto, Hajime, additional, Suzuki, Megumi, additional, Iwama, Hajime, additional, Nakai, Takehito, additional, Doi, Naofumi, additional, and Saito, Yoshihiko, additional

Published
2022
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9. Abstract 17014: Prognosis of Patients With Reduced Left Ventricular Function Undergoing Catheter Ablation for Atrial Fibrillation: From Kansai Plus Atrial Fibrillation (KPAF) Registry

Author

Fujimoto, Hajime, Toyokawa, Nozomi, Sakai, Satoshi, Yano, Hiroki, Nogi, Kazutaka, Iwai, Atsushi, Hashimoto, Yukihiro, Suzuki, Megumi, Iwama, Hajime, Nakai, Takehito, Doi, Naofumi, Hirai, Kaeko, Naito, Masaki, Shizuta, Satoshi, Kimura, Takeshi, Atsushi, Kobori, Inoue, Koichi, Kaitani, Kazuaki, Morimoto, Takeshi, Kurotobi, Toshiya, Morishima, Itsuro, Shirayama, Takeshi, Okajima, Katsunori, Satomi, Kazuhiro, Higashi, Yukei, Ikeguchi, Shigeru, Yamaji, Hirosuke, Matsui, Yumie, Horie, Minoru, Ito, Makoto, Nakazawa, Yuko, Yao, Takenori, F. Kusano, Kengo, Shimizu, Wataru, and Kamakura, Shiro

Published
2017

12. 心不全を合併した心房細動患者のカテーテルアブレーション後の長期予後 : 左室駆出率に基づいた心不全のサブタイプ間における比較

Author

Fujimoto, Hajime, Doi, Naofumi, Okayama, Satoshi, Naito, Masaki, Kobori, Atsushi, Kaitani, Kazuaki, Inoue, Koichi, Kurotobi, Toshiya, Morishima, Itsuro, Yamaji, Hirosuke, Matsui, Yumie, Nakazawa, Yuko, Kusano, Kengo, Hirai, Kaeko, Nakai, Takehito, Suzuki, Megumi, Yano, Hiroki, Sakai, Satoshi, Kimura, Takeshi, Shizuta, Satoshi, and Saito, Yoshihiko

Subjects
Ejection fraction, Catheter ablation, Heart failure, Atrial fibrillation
Abstract

Aims: Heart failure (HF) prognosis has been reported similar in patients with preserved vs. reduced left ventricular ejection fraction (LVEF). This study compared the long-term prognosis of HF patients undergoing radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF). Methods and results: Among 5010 patients undergoing RFCA in Kansai Plus AF registry, 656 patients (13.1%) with a documented history of HF were enrolled in the study before RFCA. The primary endpoint was a composite of all-cause death, HF hospitalization, and stroke or systemic embolism. Patients with reduced (, 博士（医学）・甲第802号・令和3年12月21日, Copyright: © Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021., This is a pre-copyedited, author-produced version of an article accepted for publication in Europace following peer review. The version of record "Europace Online ahead of print (2021 Aug 31;euab201) is available online at: https://doi.org/10.1093/europace/euab201., 発行元が定める登録猶予期間終了の後、本文を登録予定（2023.04）

Published
2021

13. Abstract 13849: Association of Optimal Blood Pressure and Risk of Atrial Fibrillation in Aged Type 2 Diabetes Mellitus Patients: From the JPAD Cohort Study

Author

Matsumoto, Chisa, primary, Ogawa, Hisao, additional, Saito, Yoshihiko, additional, Okada, Sadanori, additional, Soejima, Hirofumi, additional, Sakuma, Mio, additional, Masuda, Izuru, additional, Nakayama, Masafumi, additional, Doi, Naofumi, additional, Jinnouchi, Hideaki, additional, Waki, Masako, additional, and Morimoto, Takeshi, additional

Published
2021
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15. INCIDENCE OF NONVALVULAR ATRIAL FIBRILLATION IN AGED TYPE 2 DIABETES MELLITUS PATIENTS: FROM JPAD COHORT STUDY

Author

Matsumoto, Chisa, primary, Ogawa, Hisao, additional, Saito, Yoshihiko, additional, Okada, Sadanori, additional, Soejima, Hirofumi, additional, Sakuma, Mio, additional, Masuda, Izuru, additional, Nakayama, Masafumi, additional, Doi, Naofumi, additional, Jinnouchi, Hideaki, additional, Waki, Masako, additional, and Morimoto, Takeshi, additional

Published
2021
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18. Association Between Statins and Cancer Incidence in Diabetes: a Cohort Study of Japanese Patients with Type 2 Diabetes

Author

Okada, Sadanori, primary, Morimoto, Takeshi, additional, Ogawa, Hisao, additional, Soejima, Hirofumi, additional, Matsumoto, Chisa, additional, Sakuma, Mio, additional, Nakayama, Masafumi, additional, Doi, Naofumi, additional, Jinnouchi, Hideaki, additional, Waki, Masako, additional, Masuda, Izuru, additional, and Saito, Yoshihiko, additional

Published
2020
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19. Effects of Fatty Acid Therapy in Addition to Strong Statin on Coronary Plaques in Acute Coronary Syndrome: An Optical Coherence Tomography Study

Author

Kita, Yoko, primary, Watanabe, Makoto, additional, Kamon, Daisuke, additional, Ueda, Tomoya, additional, Soeda, Tsunenari, additional, Okayama, Satoshi, additional, Ishigami, Kenichi, additional, Kawata, Hiroyuki, additional, Horii, Manabu, additional, Inoue, Fumitaka, additional, Doi, Naofumi, additional, Okura, Hiroyuki, additional, Uemura, Shiro, additional, and Saito, Yoshihiko, additional

Published
2020
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21. Long-term prognosis of patients undergoing radiofrequency catheter ablation for atrial fibrillation: comparison between heart failure subtypes based on left ventricular ejection fraction.

Author

Fujimoto, Hajime, Doi, Naofumi, Okayama, Satoshi, Naito, Masaki, Kobori, Atsushi, Kaitani, Kazuaki, Inoue, Koichi, Kurotobi, Toshiya, Morishima, Itsuro, Yamaji, Hirosuke, Matsui, Yumie, Nakazawa, Yuko, Kusano, Kengo, Hirai, Kaeko, Nakai, Takehito, Suzuki, Megumi, Yano, Hiroki, Sakai, Satoshi, Kimura, Takeshi, and Shizuta, Satoshi

Abstract

Aims: Heart failure (HF) prognosis has been reported similar in patients with preserved vs. reduced left ventricular ejection fraction (LVEF). This study compared the long-term prognosis of HF patients undergoing radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF).Methods and Results: Among 5010 patients undergoing RFCA in Kansai Plus AF registry, 656 patients (13.1%) with a documented history of HF were enrolled in the study before RFCA. The primary endpoint was a composite of all-cause death, HF hospitalization, and stroke or systemic embolism. Patients with reduced (<40%), mid-range (40-49%), and preserved (≥50%) LVEF were 98 (14.9%), 107 (16.3%), and 451 (68.8%) patients, respectively. The prevalence of ischaemic heart disease and cardiomyopathies was higher among patients with reduced as compared with preserved LVEF (27.6% vs. 10.0%, P < 0.05 and 36.7% vs. 15.3%, P < 0.05, respectively). The median follow-up period was 2.9 years. The 3-year cumulative risk for the primary endpoint was higher in patients with reduced LVEF (32.7%) compared to those with mid-range (11.7%) or preserved (11.6%) LVEF (P < 0.001). Reduced LVEF was the most significant independent risk factor for primary endpoint (hazard ratio, 2.83; 95% confidence interval 1.74-4.61, P < 0.001). The 3-year arrhythmia recurrence rate was similar among the groups (48.2%, 42.8%, and 47.3%, respectively, P = 0.75).Conclusion: This study raises hypothesis that patients with HFrEF and AF had approximately three times higher risk for a composite of all-cause death, HF hospitalization, and stroke or systemic embolism after AF ablation compared with patients with HFmrEF or HFpEF. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Dual Antiplatelet Therapy for 6 Versus 18 Months After Biodegradable Polymer Drug-Eluting Stent Implantation

Author

Nakamura, Masato, primary, Iijima, Raisuke, additional, Ako, Junya, additional, Shinke, Toshiro, additional, Okada, Hisayuki, additional, Ito, Yoshiaki, additional, Ando, Kenji, additional, Anzai, Hitoshi, additional, Tanaka, Hiroyuki, additional, Ueda, Yasunori, additional, Takiuchi, Shin, additional, Nishida, Yasunori, additional, Ohira, Hiroshi, additional, Kawaguchi, Katsuhiro, additional, Kadotani, Makoto, additional, Niinuma, Hiroyuki, additional, Omiya, Kazuto, additional, Morita, Takashi, additional, Zen, Kan, additional, Yasaka, Yoshinori, additional, Inoue, Kenji, additional, Ishiwata, Sugao, additional, Ochiai, Masahiko, additional, Hamasaki, Toshimitsu, additional, Yokoi, Hiroyoshi, additional, Hara, Hidehiko, additional, Yaita, Yoshinori, additional, Takamisawa, Itaru, additional, Yajima, Junji, additional, Ishihara, Takayuki, additional, Nakamura, Shigeru, additional, Fujii, Kenshi, additional, Ashida, Kazuhiro, additional, Ota, Hiroshi, additional, Okutsu, Masaaki, additional, Oshima, Masao, additional, Kongoji, Ken, additional, Jinno, Yasushi, additional, Shutta, Ryu, additional, Shiode, Nobuo, additional, Oumi, Tetsuo, additional, Doijiri, Tatsuki, additional, Yokoi, Yoshiaki, additional, Ogawa, Takayuki, additional, Kimura, Keizo, additional, Munemasa, Mitsuru, additional, Mukawa, Hiroaki, additional, Komiyama, Kota, additional, Suzuki, Takeshi, additional, Inoue, Takumi, additional, Ueno, Takafumi, additional, Sugano, Teruyasu, additional, Yamashita, Jun, additional, Yasumura, Yoshio, additional, Kamiya, Haruo, additional, Fujita, Hiroshi, additional, Urasawa, Kazushi, additional, Ono, Shiro, additional, Ajioka, Masayoshi, additional, Ando, Jiro, additional, Mizuno, Koichi, additional, Hirayama, Haruo, additional, Tojo, Taiki, additional, Maekawa, Yuichiro, additional, Kawasaki, Tomohiro, additional, Okamura, Takayuki, additional, Toyota, Fumitoshi, additional, Hikichi, Yutaka, additional, Michishita, Ichiro, additional, Yagi, Takafumi, additional, Kamihata, Hiroshi, additional, Shindo, Naohisa, additional, Ishizaka, Nobukazu, additional, Ashikaga, Takashi, additional, Ozaki, Yukio, additional, Hara, Hisao, additional, Sakamoto, Hiroshi, additional, Kada, Kenji, additional, Doi, Naofumi, additional, Honye, Junko, additional, Takano, Hitoshi, additional, Kawata, Masahito, additional, Houzawa, Hidenori, additional, Ozawa, Toru, additional, Kikuchi, Arifumi, additional, Kadota, Kazushige, additional, Kijima, Yoichi, additional, Ikemoto, Tomokazu, additional, Shimada, Yoshihisa, additional, Yumoto, Kazuhiko, additional, Kawajiri, Kenji, additional, Nozaki, Yoichi, additional, Sakakibara, Masayoshi, additional, Tosaka, Atsushi, additional, Noma, Shigetaka, additional, Wakabayashi, Yasushi, additional, Okada, Masaharu, additional, Hirose, Mizuki, additional, Takagi, Yuichiro, additional, Takagi, Takuro, additional, Miyauchi, Katsumi, additional, Misu, Kazuhiko, additional, Yasuda, Satoshi, additional, Yoshikawa, Ryohei, additional, Inoue, Ichiro, additional, Yoshiyama, Minoru, additional, Masuyama, Toru, additional, Tomobuchi, Yoshiaki, additional, Yamazaki, Seiji, additional, Tanabe, Kengo, additional, Wagatsuma, Kenji, additional, Kato, Masayuki, additional, Kawai, Kazuya, additional, Hamazaki, Yuji, additional, Yamagishi, Masakazu, additional, Shibata, Yoshisato, additional, Watanabe, Kouki, additional, Tachibana, Koichi, additional, Wada, Hiroshi, additional, Ninomiya, Kenji, additional, Suzuki, Hiroshi, additional, Yoshioka, Jiro, additional, Mori, Chikara, additional, Sonoda, Masahiro, additional, Kataoka, Toru, additional, Terai, Hidenobu, additional, Onishi, Yuko, additional, Toma, Masanao, additional, Serikawa, Takeshi, additional, Otsuka, Yoritaka, additional, Yano, Shoji, additional, Ebisawa, Soichiro, additional, Takashima, Hiroaki, additional, Shimomura, Hideki, additional, Kurumatani, Yoko, additional, Sonoda, Shinjo, additional, and Uehara, Hiroki, additional

Published
2017
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25. ENHANCED PLATELET AGGREGABILITY UNDER HIGH SHEAR STRESS IN CORONARY CIRCULATION OF PATIENTS WITH UNSTABLE ANGINA

Author

Doi, Naofumi

Subjects
platelet, unstable angina, coronary circulation, cardiovascular diseases, von Willebrand factor, shear stress
Abstract

Mechanical forces, including high shear stress, have been found to cause platelet aggregation. Although increased platelet aggregation is also associated with the pathophysiology of unstable angina, it is not known whether platelet aggregation induced by high shear stress occurs in the coronary circulation of patients with unstable angina. We assayed high shear stress induced platelet aggregation (h-SIPA) in each of 25 patients with unstable angina and a severe stenotic lesion of the left coronary artery, and in 5 patients with chest pain syndrome as controls. We obtained blood from the coronary ostium and coronary sinus of each subject during angiography and measured h-SIPA of each sample with a modified cone-and-plate type viscometer set at 108 dyne/cm^2. In the patients with unstable angina, h-SIPA of the samples from the coronary sinus was significantly higher than in those from the coronary ostium (p＜0.01). However, we detected no differences between blood from the coronary ostium and coronary sinus in samples from the control subjects. Although h-SIPA has been known to be mediated by the interaction between platelets and von Willebrand factor (vWF), we found no differences in the concentrations of vWF antigen or ristocetin cofactor activity between plasma from coronary ostium and coronary sinus of the patients with unstable angina. Platelet aggregation under conditions of high shear stress is enhanced in the coronary circulation of patients with unstable angina. These results suggest that treatment of these patients with an agent that prevents h-SIPA may be beneficial.

Published
2000

26. Effect of Aspirin on Cancer Chemoprevention in Japanese Patients With Type 2 Diabetes: 10-Year Observational Follow-up of a Randomized Controlled Trial.

Author

Sadanori Okada, Takeshi Morimoto, Hisao Ogawa, Mio Sakuma, Chisa Matsumoto, Hirofumi Soejima, Masafumi Nakayama, Naofumi Doi, Hideaki Jinnouchi, Masako Waki, Izuru Masuda, Yoshihiko Saito, Okada, Sadanori, Morimoto, Takeshi, Ogawa, Hisao, Sakuma, Mio, Matsumoto, Chisa, Soejima, Hirofumi, Nakayama, Masafumi, and Doi, Naofumi

Subjects
PEOPLE with diabetes, CANCER prevention, ASPIRIN, TYPE 2 diabetes, LONGITUDINAL method
Abstract

Objective: This study analyzed the efficacy of low-dose aspirin in cancer chemoprevention in patients with diabetes.Research Design and Methods: This study was a posttrial follow-up of the Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes (JPAD) trial. Participants in the JPAD trial (2,536 Japanese patients with type 2 diabetes and without preexisting cardiovascular disease) were randomly allocated to receive aspirin (81 or 100 mg daily) or no aspirin. After that trial ended in 2008, we followed up with the participants until 2015, with no attempt to change the previously assigned therapy. The primary end point was total cancer incidence. We investigated the effect of low-dose aspirin on cancer incidence.Results: During the median follow-up period of 10.7 years, a total of 318 cancers occurred. The cancer incidence was not significantly different between the aspirin and no-aspirin groups (log-rank, P = 0.4; hazard ratio [HR], 0.92; 95% CI, 0.73-1.14; P = 0.4). In subgroup analyses, aspirin did not affect cancer incidence in men, women, or participants aged ≥65 years. However, it decreased cancer incidence in participants aged <65 years (log-rank, P = 0.05; HR, 0.67; 95% CI, 0.44-0.99; P = 0.048). After adjusting for sex, hemoglobin A1c, smoking status, and administration of metformin and statins, aspirin significantly reduced cancer incidence in participants aged <65 years (adjusted HR, 0.66; 95% CI, 0.43-0.99; P = 0.04).Conclusions: Low-dose aspirin did not reduce cancer incidence in Japanese patients with type 2 diabetes. [ABSTRACT FROM AUTHOR]

Published
2018
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27. Abstract 17470: The Effectiveness of Ethanol Infusion in the Vein of Marshall for Bidirectional Mitral Isthmus Block in Unsuccessful Cases With Conventional Ablation

Author

Hirai, Kaeko, primary, Fujimoto, Hajime, additional, Naito, Masaki, additional, Yano, Hiroki, additional, Kosugi, Takaaki, additional, Hashimoto, Yukihiro, additional, Isojima, Takuya, additional, Suzuki, Megumi, additional, Iwama, Hajime, additional, Nakai, Takehito, additional, and Doi, Naofumi, additional

Published
2015
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28. Abstract 12200: Blood Pressure Control in Diabetic Patients is Most Effective Between Ages 65 to 75 for Prevention of Atherosclerotic Events

Author

Soejima, Hirofumi, primary, Morimoto, Takeshi, additional, Okada, Sadanori, additional, Sakuma, Mio, additional, Nakayama, Masafumi, additional, Uemura, Shiro, additional, Masao, Kanauchi, additional, Doi, Naofumi, additional, Jinnouchi, Hideaki, additional, Sugiyama, Seigo, additional, Waki, Masako, additional, Saito, Yoshihiko, additional, and Ogawa, Hisao, additional

Published
2015
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29. Abstract 12161: Dipeptidyl Peptidase IV Inhibitor Therapy Modifies Systolic Blood Pressure in High Blood Pressure Diabetic Patients: Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) 2 Trial

Author

Soejima, Hirofumi, primary, Morimoto, Takeshi, additional, Okada, Sadanori, additional, Sakuma, Mio, additional, Nakayama, Masafumi, additional, Uemura, Shiro, additional, Kanauchi, Masao, additional, Doi, Naofumi, additional, Jinnouchi, Hideaki, additional, Sugiyama, Seigo, additional, Waki, Masako, additional, Saito, Yoshihiko, additional, and Ogawa, Hisao, additional

Published
2014
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30. ENHANCED PLATELET AGGREGABILITY UNDER HIGH SHEAR STRESS IN CORONARY CIRCULATION OF PATIENTS WITH UNSTABLE ANGINA

Author

Doi, Naofumi and Doi, Naofumi

Abstract

Mechanical forces, including high shear stress, have been found to cause platelet aggregation. Although increased platelet aggregation is also associated with the pathophysiology of unstable angina, it is not known whether platelet aggregation induced by high shear stress occurs in the coronary circulation of patients with unstable angina. We assayed high shear stress induced platelet aggregation (h-SIPA) in each of 25 patients with unstable angina and a severe stenotic lesion of the left coronary artery, and in 5 patients with chest pain syndrome as controls. We obtained blood from the coronary ostium and coronary sinus of each subject during angiography and measured h-SIPA of each sample with a modified cone-and-plate type viscometer set at 108 dyne/cm^2. In the patients with unstable angina, h-SIPA of the samples from the coronary sinus was significantly higher than in those from the coronary ostium (p＜0.01). However, we detected no differences between blood from the coronary ostium and coronary sinus in samples from the control subjects. Although h-SIPA has been known to be mediated by the interaction between platelets and von Willebrand factor (vWF), we found no differences in the concentrations of vWF antigen or ristocetin cofactor activity between plasma from coronary ostium and coronary sinus of the patients with unstable angina. Platelet aggregation under conditions of high shear stress is enhanced in the coronary circulation of patients with unstable angina. These results suggest that treatment of these patients with an agent that prevents h-SIPA may be beneficial.

Published
2008

31. Aspirin Reduces Cerebrovascular Events in Type 2 Diabetic Patients With Poorly Controlled Blood Pressure

Author

Soejima, Hirofumi, primary, Ogawa, Hisao, additional, Morimoto, Takeshi, additional, Nakayama, Masafumi, additional, Okada, Sadanori, additional, Uemura, Shiro, additional, Kanauchi, Masao, additional, Doi, Naofumi, additional, Sakuma, Mio, additional, Jinnouchi, Hideaki, additional, Sugiyama, Seigo, additional, Waki, Masako, additional, and Saito, Yoshihiko, additional

Published
2012
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32. Abstract 9876: Relative Efficacy of Aspirin Therapy in Relation to C-Reactive Protein Levels in Type 2 Diabetic Patients: Subgroup Analysis Derived From the JPAD Trial

Author

Soejima, Hirofumi, primary, Nakayama, Masafumi, additional, Morimoto, Takeshi, additional, Sakuma, Mio, additional, Okada, Sadanori, additional, Uemura, Shiro, additional, Kanauchi, Masao, additional, Doi, Naofumi, additional, Jinnouchi, Hideaki, additional, Sugiyama, Seigo, additional, Waki, Masako, additional, Saito, Yoshihiko, additional, and Ogawa, Hisao, additional

Published
2011
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33. Cardiac Expression of Placental Growth Factor Predicts the Improvement of Chronic Phase Left Ventricular Function in Patients With Acute Myocardial Infarction

Author

Iwama, Hajime, primary, Uemura, Shiro, additional, Naya, Noriyuki, additional, Imagawa, Kei-ichi, additional, Takemoto, Yasuhiro, additional, Asai, Osamu, additional, Onoue, Kenji, additional, Okayama, Satoshi, additional, Somekawa, Satoshi, additional, Kida, Yoshitomi, additional, Takeda, Yukiji, additional, Nakatani, Kimihiko, additional, Takaoka, Minoru, additional, Kawata, Hiroyuki, additional, Horii, Manabu, additional, Nakajima, Tamio, additional, Doi, Naofumi, additional, and Saito, Yoshihiko, additional

Published
2006
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37. Increased plasma concentrations of adrenomedullin correlate with relaxation of vascular tone in patients with septic shock

Author

Nishio, Kenji, primary, Akai, Yasuhiro, additional, Murao, Yoshinori, additional, Doi, Naofumi, additional, Ueda, Shiro, additional, Tabuse, Hisayuki, additional, Miyamoto, Seiji, additional, Dohi, Kazuhiro, additional, Minamino, Naoto, additional, Shoji, Hiroki, additional, Kitamura, Kazuo, additional, Kangawa, Kenji, additional, and Matsuo, Hisayuki, additional

Published
1997
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39. PROMINENT ELEVATION OF PLASMA ADRENOMEDULLIN LEVELS IN SEPTIC PATIENTS

Author

Dohi Kazuhiro, Akai Yasuhiro, Shoji Hiroki, Kitamura Kazuo, Miyamoto Seiji, Matsuo Hisayuki, Tabuse Hisayuki, Minamino Naoto, Kangawa Kenji, Nishio Kenji, Doi Naofumi, and Murao Yoshinori

Subjects
Adrenomedullin, medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, Emergency Medicine, Elevation, Medicine, Critical Care and Intensive Care Medicine, business
Published
1995
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43. Prevention of Contrast-Induced Nephropathy After Cardiovascular Catheterization and Intervention With High-Dose Strong Statin Therapy in Japan　- The PREVENT CINC-J Study.

Author

Watanabe M, Aonuma K, Murohara T, Okumura Y, Morimoto T, Okada S, Nakamura S, Uemura S, Kuwahara K, Takayama T, Doi N, Nakajima T, Horii M, Ishigami K, Nomoto K, Abe D, Oiwa K, Tanaka K, Koyama T, Sato A, Ueda T, Soeda T, and Saito Y

Subjects
Catheterization, Contrast Media adverse effects, Coronary Angiography methods, Creatinine, Humans, Japan, Prospective Studies, Treatment Outcome, Hydroxymethylglutaryl-CoA Reductase Inhibitors adverse effects, Kidney Diseases chemically induced, Kidney Diseases prevention & control
Abstract

Background: Previous studies have reported that high-dose strong statin therapy reduces the incidence of contrast-induced nephropathy (CIN) in statin naïve patients; however, the efficacy of high-dose strong statins for preventing CIN in real-world clinical practice remains unclear. The aim of this study was to evaluate the efficacy of strong statin therapy in addition to fluid hydration for preventing CIN after cardiovascular catheterization., Methods and results: This prospective, multicenter, randomized controlled trial included 420 patients with chronic kidney disease who underwent cardiovascular catheterization. They were assigned to receive high-dose pitavastatin (4 mg/day × 4 days) on the day before and of the procedure and 2 days after the procedure (Statin group, n=213) or no pitavastatin (Control group, n=207). Isotonic saline hydration combined with a single bolus of sodium bicarbonate (20 mEq) was scheduled for administration to all patients. In the control group, statin therapy was continued at the same dose as that before randomization. CIN was defined as a ≥0.5 mg/dL increase in serum creatinine or ≥25% above baseline at 48 h after contrast exposure. Before randomization, 83% of study participants were receiving statin treatment. The statin group had a higher incidence of CIN than the control group (3.0% vs. 0%, P=0.01). The 12-month rate of major adverse cardiovascular events was similar between the 2 groups., Conclusions: High-dose pitavastatin increases the incidence of CIN in this study population.

Published
2022
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44. Long-term prognosis of patients undergoing radiofrequency catheter ablation for atrial fibrillation: comparison between heart failure subtypes based on left ventricular ejection fraction.

Author

Fujimoto H, Doi N, Okayama S, Naito M, Kobori A, Kaitani K, Inoue K, Kurotobi T, Morishima I, Yamaji H, Matsui Y, Nakazawa Y, Kusano K, Hirai K, Nakai T, Suzuki M, Yano H, Sakai S, Kimura T, Shizuta S, and Saito Y

Subjects
Humans, Prognosis, Stroke Volume physiology, Ventricular Function, Left, Atrial Fibrillation diagnosis, Atrial Fibrillation surgery, Catheter Ablation adverse effects, Catheter Ablation methods, Heart Failure diagnosis, Heart Failure epidemiology
Abstract

Aims: Heart failure (HF) prognosis has been reported similar in patients with preserved vs. reduced left ventricular ejection fraction (LVEF). This study compared the long-term prognosis of HF patients undergoing radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF)., Methods and Results: Among 5010 patients undergoing RFCA in Kansai Plus AF registry, 656 patients (13.1%) with a documented history of HF were enrolled in the study before RFCA. The primary endpoint was a composite of all-cause death, HF hospitalization, and stroke or systemic embolism. Patients with reduced (<40%), mid-range (40-49%), and preserved (≥50%) LVEF were 98 (14.9%), 107 (16.3%), and 451 (68.8%) patients, respectively. The prevalence of ischaemic heart disease and cardiomyopathies was higher among patients with reduced as compared with preserved LVEF (27.6% vs. 10.0%, P < 0.05 and 36.7% vs. 15.3%, P < 0.05, respectively). The median follow-up period was 2.9 years. The 3-year cumulative risk for the primary endpoint was higher in patients with reduced LVEF (32.7%) compared to those with mid-range (11.7%) or preserved (11.6%) LVEF (P < 0.001). Reduced LVEF was the most significant independent risk factor for primary endpoint (hazard ratio, 2.83; 95% confidence interval 1.74-4.61, P < 0.001). The 3-year arrhythmia recurrence rate was similar among the groups (48.2%, 42.8%, and 47.3%, respectively, P = 0.75)., Conclusion: This study raises hypothesis that patients with HFrEF and AF had approximately three times higher risk for a composite of all-cause death, HF hospitalization, and stroke or systemic embolism after AF ablation compared with patients with HFmrEF or HFpEF., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.)

Published
2022
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45. Sex Difference in Effects of Low-Dose Aspirin on Prevention of Dementia in Patients With Type 2 Diabetes: A Long-term Follow-up Study of a Randomized Clinical Trial.

Author

Matsumoto C, Ogawa H, Saito Y, Okada S, Soejima H, Sakuma M, Masuda I, Nakayama M, Doi N, Jinnouchi H, Waki M, and Morimoto T

Subjects
Adult, Aged, Aged, 80 and over, Aspirin pharmacology, Atherosclerosis epidemiology, Atherosclerosis etiology, Cohort Studies, Dementia epidemiology, Dementia etiology, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 epidemiology, Diabetes Mellitus, Type 2 psychology, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Humans, Incidence, Japan epidemiology, Male, Middle Aged, Primary Prevention methods, Risk Factors, Sex Characteristics, Aspirin administration & dosage, Atherosclerosis prevention & control, Dementia prevention & control, Diabetes Mellitus, Type 2 drug therapy
Abstract

Objective: To evaluate and compare the efficacy of long-term use of low-dose aspirin for the prevention of dementia in men and women., Research Design and Methods: This study is a follow-up cohort study of the Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) trial, which was a randomized, open-label, standard care-controlled trial examining the effects of low-dose aspirin on cardiovascular events. We followed up 2,536 Japanese patients with type 2 diabetes (T2D) enrolled in the JPAD trial from 2002 to 2017. The primary outcome of this post hoc analysis was the incidence of dementia, which was defined by the prescription of antidementia drugs or admission due to dementia., Results: Among the originally enrolled patients, 2,121 (84%) retained their original allocation. During a median follow-up of 11.4 years, 128 patients developed dementia. The overall effect of low-dose aspirin on the prevention of dementia adjusted for age, sex, and other established risk factors was not significant (hazard ratio [HR] 0.82, 95% CI 0.58-1.16). However, a significant reduction was seen in the risk of dementia in women (HR 0.58, 95% CI 0.36-0.95), but not in men (HR 1.27, 95% CI 0.75-2.13) ( P interaction = 0.03)., Conclusions: Long-term use of low-dose aspirin may reduce the risk for dementia in women with T2D., (© 2019 by the American Diabetes Association.)

Published
2020
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46. Effect of low-dose aspirin on primary prevention of cardiovascular events in Japanese diabetic patients at high risk.

Author

Okada S, Morimoto T, Ogawa H, Sakuma M, Soejima H, Nakayama M, Sugiyama S, Jinnouchi H, Waki M, Doi N, Horii M, Kawata H, Somekawa S, Soeda T, Uemura S, and Saito Y

Subjects
Adult, Age Factors, Aged, Asian People, Female, Humans, Japan, Male, Middle Aged, Prospective Studies, Risk Factors, Aspirin administration & dosage, Cardiovascular Diseases prevention & control, Diabetes Complications drug therapy, Platelet Aggregation Inhibitors administration & dosage
Abstract

Background: Benefit of low-dose aspirin for primary prevention of cardiovascular events in diabetes remains controversial. The American Diabetes Association (ADA), the American Heart Association (AHA), and the American College of Cardiology Foundation (ACCF) recommend aspirin for high-risk diabetic patients: older patients with additional cardiovascular risk factors. We evaluated aspirin's benefit in Japanese diabetic patients stratified by cardiovascular risk., Methods and Results: In the JPAD trial, we enrolled 2,539 Japanese patients with type 2 diabetes and no history of cardiovascular disease. We randomly assigned them to aspirin (81-100 mg daily) or no aspirin groups. The median follow-up period was 4.4 years. We stratified the patients into high-risk or low-risk groups, according to the US recommendation: age (older; younger) and coexisting cardiovascular risk factors. The risk factors included smoking, hypertension, dyslipidemia, family history of coronary artery disease, and proteinuria. Most of the patients were classified into the high-risk group, consisting of older patients with risk factors (n=1,804). The incidence of cardiovascular events was higher in this group, but aspirin did not reduce cardiovascular events (hazard ratio [HR], 0.83; 95% confidence interval [CI]: 0.58-1.17). In the low-risk group, consisting of older patients without risk factors and younger patients (n=728), aspirin did not reduce cardiovascular events (HR, 0.55; 95% CI: 0.23-1.21). These results were unchanged after adjusting for potential confounding factors., Conclusions: Low-dose aspirin is not beneficial in Japanese diabetic patients at high risk.

Published
2013
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