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21 results on '"Doi, Mariko"'

8. Optimization of therapeutic strategy for p16‐positive oropharyngeal squamous cell carcinoma: Multi‐institutional observational study based on the national Head and Neck Cancer Registry of Japan

Author

Saito, Yuki, primary, Hayashi, Ryuichi, additional, Iida, Yoshiyuki, additional, Mizumachi, Takatsugu, additional, Fujii, Takashi, additional, Matsumoto, Fumihiko, additional, Beppu, Takeshi, additional, Yoshida, Masafumi, additional, Shinomiya, Hirotaka, additional, Kamiyama, Ryosuke, additional, Kitano, Mutsukazu, additional, Yokoshima, Kazuhiko, additional, Fujimoto, Yasushi, additional, Hama, Takanori, additional, Yamashita, Taku, additional, Okami, Kenji, additional, Miura, Kouki, additional, Fujisawa, Takuo, additional, Sano, Daisuke, additional, Kato, Hisayuki, additional, Minami, Shujiro, additional, Sugasawa, Masashi, additional, Masuda, Muneyuki, additional, Ota, Ichiro, additional, Iwae, Shigemichi, additional, Kawata, Ryo, additional, Monden, Nobuya, additional, Imai, Takayuki, additional, Asakage, Takahiro, additional, Okada, Masafumi, additional, Yoshikawa, Takanori, additional, Tanioka, Kensuke, additional, Kitayama, Megumi, additional, Doi, Mariko, additional, Fujii, Satoshi, additional, Fujii, Masato, additional, Oridate, Nobuhiko, additional, Nakamizo, Munenaga, additional, Yoshimoto, Seiichi, additional, Homma, Akihiro, additional, Nibu, Ken‐ichi, additional, and Yane, Katsunari, additional

Published
2020
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12. Effect of Neoadjuvant Nab-Paclitaxel plus Gemcitabine Therapy on Overall Survival in Patients with Borderline Resectable Pancreatic Cancer: A Prospective Multicenter Phase II Trial (NAC-GA Trial).

Author

Okada, Ken-ichi, Shimokawa, Toshio, Hirono, Seiko, Kawai, Manabu, Sho, Masayuki, Satoi, Sohei, Matsumoto, Ippei, Eguchi, Hidetoshi, Murakami, Yoshiaki, Yamada, Suguru, Doi, Mariko, and Yamaue, Hiroki

Subjects
ANTIMETABOLITES, COMBINATION drug therapy, CLINICAL trials, COMBINED modality therapy, LONGITUDINAL method, MEDICAL cooperation, PACLITAXEL, PANCREATIC tumors, RESEARCH, SURVIVAL, TUMOR treatment
Abstract

We conducted a prospective multicenter phase II trial of patients with borderline resectable pancreatic carcinoma to investigate the efficacy of neoadjuvant nab-paclitaxel plus gemcitabine thera py on ov erall survival (OS). The clinical trial primarily evaluated OS time from the first day of protocol therapy as a primary endpoint. The secondary endpoints were recurrence-free survival from the first day of protocol therapy, safety of the protocol therapy (adverse effect), mor-bidity based on the Clavien Dindo classification of more than III, response rate, preoperative/postoperative tumor marker (CA 19-9, CEA), rate of normalization, reduction rate of the maximum standardized uptake value on positron emission tomography-computed tomography (limited to institutions where positron emission tomography-computed tomography was available), chemotherapeutic effect grade based on Evans' classification, resection rate, R0 resection rate, surgical data (operative time, blood loss, transfusion, postoperative hospital day), overall morbidity rates (reoperation, rate of readmission, mortality), patient rate in postoperative adjuvant therapy (entry rate, completion rate), dose intensity, quality of life regarding fatigue and malaise assessed by the questionnaire of FACIT-F (Japanese version), and peripheral sensory neuropathy assessed by the questionnaire of the FACT/GOG-NTX subscale (version 4; Japanese version). Sixty patients were included in the study, and 18 leading Japanese institutions and hospitals (all high-volume centers in pancreatic surgery) participated in this trial. [ABSTRACT FROM AUTHOR]

Published
2017
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13. The Speckle Tracking Imaging for the Assessment of Cardiac Resynchronization Therapy (START) Study

Author

Maruo, Takeshi, primary, Seo, Yoshihiro, additional, Yamada, Satoshi, additional, Arita, Takeshi, additional, Ishizu, Tomoko, additional, Shiga, Tsuyoshi, additional, Dohi, Kaoru, additional, Toide, Hiroyuki, additional, Furugen, Azusa, additional, Inoue, Katsuji, additional, Daimon, Masao, additional, Kawai, Hiroya, additional, Tsuruta, Hikaru, additional, Nishigami, Kazuhiro, additional, Yuda, Satoshi, additional, Ozawa, Tomoya, additional, Izumi, Chisato, additional, Fumikura, Yuko, additional, Wada, Yasuaki, additional, Doi, Mariko, additional, Okada, Masafumi, additional, Takenaka, Katsu, additional, and Aonuma, Kazutaka, additional

Published
2015
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14. Arsenic Exposure Affects Plasma Insulin-Like Growth Factor 1 (IGF-1) in Children in Rural Bangladesh

Author

Ahmed, Sultan, Rekha, Rokeya Sultana, Bin Ahsan, Khalid, Doi, Mariko, Grander, Margaretha, Roy, Anjan Kumar, Ekström, Eva-Charlotte, Wagatsuma, Yukiko, Vahter, Marie, Raqib, Rubhana, Ahmed, Sultan, Rekha, Rokeya Sultana, Bin Ahsan, Khalid, Doi, Mariko, Grander, Margaretha, Roy, Anjan Kumar, Ekström, Eva-Charlotte, Wagatsuma, Yukiko, Vahter, Marie, and Raqib, Rubhana

Abstract

Background: Exposure to inorganic arsenic (As) through drinking water during pregnancy is associated with lower birth size and child growth. The aim of the study was to assess the effects of As exposure on child growth parameters to evaluate causal associations. Methodology/Findings: Children born in a longitudinal mother-child cohort in rural Bangladesh were studied at 4.5 years (n=640) as well as at birth (n=134). Exposure to arsenic was assessed by concurrent and prenatal (maternal) urinary concentrations of arsenic metabolites (U-As). Associations with plasma concentrations of insulin-like growth factor 1 (IGF-1), calcium (Ca), vitamin D (Vit-D), bone-specific alkaline phosphatase (B-ALP), intact parathyroid hormone (iPTH), and phosphate (PO4) were evaluated by linear regression analysis, adjusted for socioeconomic factor, parity and child sex. Child U-As (per 10 mu g/L) was significantly inversely associated with concurrent plasma IGF-1 (beta=-0.27; 95% confidence interval: -0.50, -0.0042) at 4.5 years. The effect was more obvious in girls (beta=-0.29; -0.59, 0.021) than in boys, and particularly in girls with adequate height (beta=-0.491; -0.97, -0.02) or weight (beta=-0.47; 0.97, 0.01). Maternal U-As was inversely associated with child IGF-1 at birth (r=-0.254, P=0.003), but not at 4.5 years. There was a tendency of positive association between U-As and plasma PO4 in stunted boys (beta=0.27; 0.089, 0.46). When stratified by % monomethylarsonic acid (MMA, arsenic metabolite) (median split at 9.7%), a much stronger inverse association between U-As and IGF-1 in the girls (beta=-0.41; -0.77, -0.03) was obtained above the median split. Conclusion: The results suggest that As-related growth impairment in children is mediated, at least partly, through suppressed IGF-1 levels.

Published
2013
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15. Association between calcium in cord blood and newborn size in Bangladesh

Author

Doi, Mariko, Sultana Rekha, Rokeya, Ahmed, Sultan, Okada, Masafumi, Kumar Roy, Anjan, El Arifeen, Shams, Ekström, Eva-Charlotte, Raqib, Rubhana, Wagatsuma, Yukiko, Doi, Mariko, Sultana Rekha, Rokeya, Ahmed, Sultan, Okada, Masafumi, Kumar Roy, Anjan, El Arifeen, Shams, Ekström, Eva-Charlotte, Raqib, Rubhana, and Wagatsuma, Yukiko

Abstract

Ca status in the uterus during pregnancy has been suggested to affect fetal growth and size at birth. In Bangladesh, low Ca levels in pregnant women and low birth weight in infants are common. The present study explored the association between Ca levels in cord blood and newborn size at birth (birth weight and birth length) in Bangladesh. Samples and data included 223 women with live-born singleton deliveries in rural Bangladesh. Newborn weight and length were measured at birth. From cord blood obtained at delivery, Ca, 25-hydroxy vitamin D, bone-specific alkaline phosphatase and intact parathyroid hormone levels were determined. An association between size at birth and Ca levels in cord blood was found (birth weight, P = 0·022; birth length, P = 0·001). Associations between Ca and newborn size were further analysed using multivariate regression analyses. After adjusting for several covariates of characteristics in mothers and newborns (gestational weeks at birth, sex of newborn, socio-economic status, maternal height, BMI, age and season at birth), birth length still exhibited a significant relationship with Ca levels in cord blood (birth length, P = 0·030). The present study indicates that Ca status in cord blood might be associated with the birth length of newborns. Ca levels during gestation may affect fetal growth.

Published
2011
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19. HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme

Author

Miyata, Noriyuki, primary, Taniguchi, Kazuo, additional, Seki, Takayuki, additional, Ishimoto, Tsuyoshi, additional, Sato-Watanabe, Mariko, additional, Yasuda, Yoshiko, additional, Doi, Mariko, additional, Kametani, Shunichi, additional, Tomishima, Yasumitsu, additional, Ueki, Tomokazu, additional, Sato, Masakazu, additional, and Kameo, Kazuya, additional

Published
2001
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21. Current Status and Issues of Ethical Review for Surgical Research in Japanese University Hospitals.

Author

Doi M, Yukawa K, and Sato H

Abstract

Introduction: In clinical research, ethical review is required prior to conducting the research. A surgical procedure is a complex intervention with properties that make it more difficult to evaluate rigorously and monitor than drug treatments. This study aimed to clarify the current status and issues in the ethical review and monitoring of surgical research., Methods: We developed a self-administered questionnaire on surgical ethical review. The questionnaire was distributed to university hospitals in Japan and collected from November 2018 to February 2019. The distributed questionnaire consisted of the reviewed items, items with difficulties, and important items on ethical review. Fisher's exact test or the chi-square test was used for analysis., Results: The questionnaires from 39 medical university hospitals were completed with appropriate answers to all items. "Technical review" was conducted at a significantly lower proportion (n = 30/39, 76.9%, p = 0.002). "Evaluation of the progress and results" was also (n = 22/39, 56.4%, p < 0.001). University hospitals in which "technical aspects and ethical review" was regarded the most important and difficult were higher (n = 24/39, 61.5%; n = 26/39, 66.7%, respectively). Respondents considered not only items written in the study protocol but also those on monitoring or oversight of surgical research as difficult., Conclusions: Our findings suggest that it is necessary to improve the ethical review system and provide supports to conduct an appropriate review for surgical research, e.g., technical aspect review or study progress/result evaluation., Competing Interests: None, (Copyright © Japan Medical Association.)

Published
2022
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