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22 results on '"Doi, Hirohito"'

9. Being Overweight Is Related to Neoaortic Sinus Dilatation After Arterial Switch Operation

Author

Muneuchi, Jun, Watanabe, Mamie, Sugitani, Yuichiro, Doi, Hirohito, Furuta, Takashi, Ezaki, Hiroki, Kobayashi, Masaru, and Ochiai, Yoshie

Subjects
Adult, Arterial Switch Operation, Young Adult, Adolescent, Transposition of Great Vessels, Humans, Clinical Investigation, Overweight, Cardiology and Cardiovascular Medicine, Dilatation
Abstract

Background Neoaortic sinus dilatation is a late comorbidity after an arterial switch operation in patients with dextro-transposition of the great arteries. We aim to explore whether neoaortic sinus dilatation is related to overweight or obesity, as these affect aortic remodeling in such patients. Methods We measured neoaortic diameters including those for the annulus, sinus, sinotubular junction, and ascending aorta by echocardiography and studied the relationship between these diameters and body mass index in patients aged 15 years and older after an arterial switch operation. Results A total of 45 patients were studied. Median (interquartile range) age, body mass index, and systolic blood pressure at echocardiography were 20 (17–28) years, 21.2 (18.4–24.2) kg/m2, and 120 (112–127) mm Hg, respectively. Echocardiogram revealed the following median values (interquartile ranges): neoaortic annulus diameter, 22.2 (19.8–23.8) mm; sinus diameter, 34.6 (31.8–39.8) mm; sinotubular junction diameter, 27.5 (22.4–30.0) mm; and ascending aortic diameter, 20.4 (19.4–22.7) mm. The neoaortic sinus diameter was significantly correlated with body mass index (r = 0.41, P = .004) and was significantly larger in patients with concomitant ventricular septal defect (P < .001) and those who were over-weight (body mass index ≥25 kg/m2; P = .006). Conclusion Neoaortic sinus dilatation after an arterial switch operation is associated with being overweight during adolescence and young adulthood. It is important to prevent obesity in patients after an arterial switch operation and educate them on a healthy lifestyle.

Published
2022
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21. Pulmonary vascular resistance and compliance in individuals with trisomy 18.

Author

Hatai, Eriko, Muneuchi, Jun, Sugitani, Yuichiro, Doi, Hirohito, Furuta, Takashi, Ezaki, Hiroki, Kobayashi, Masaru, Sato, Rie, and Watanabe, Mamie

Abstract

Individuals with trisomy 18 (T18) usually have congenital heart disease, often with pulmonary hypertension, which is associated with poor outcomes. This study aimed to explore the characteristics of pulmonary circulation including pulmonary vascular resistance (Rp) and compliance (Cp) among them. We retrospectively reviewed cardiac catheterization data in subjects with T18, trisomy 21 (T21), and without chromosomal anomaly (control group) who were referred due to heart failure associated with ventricular septal defect between 2000 and 2020. Pulmonary hemodynamic parameters including Rp and Cp were compared between these groups. We studied 20 subjects with T18, 88 subjects with T21, and 240 control subjects. There was no significant difference in age (T18: 4.6 [3.0–6. 9] vs. T21: 2.8 [1.9–4.0] vs. control: 2.9 [1.6–3.2] months, p = 0.06) and mean pulmonary arterial pressure (T18: 41 [33–49] vs. T21: 35 [30–41] vs. control: 36 [28–43] mmHg, p = 0.121) between the groups. The pulmonary to systemic blood flow ratio (Qp/Qs) (p = 0.983), Rp (p = 0.449), and Cp (p = 0.195) did not differ between T18 and control groups. However, Qp/Qs and Cp in T18 group were significantly greater than that in T21 group (T18: Qp/Qs: 3.4 [2.3–5.2] vs. T: 21 2.3 [1.7–3.7], p = 0.001. Cp: 3.5 [2.3–5.5] vs. 2.3 [1.6–3.1] mmHg/mL/m2, p = 0.007), while Rp was identical between the groups (T18: 2.0 [1.6–3.3] vs. T21: 2.3 [1.7–3.7], p = 0.386). The pulmonary circulation in T18 subjects differed from that observed in T21 subjects, and identical to that observed in control subjects. Pulmonary hypertension is expected to be normalized after reasonable corrective surgery in T18 patients with congenital heart disease. [ABSTRACT FROM AUTHOR]

Published
2022
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