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24 results on '"Dohi, Chihiro"'

3. Serum N-glycan profiles in patients with intraductal papillary mucinous neoplasms of the pancreas

Author

Akimoto, Yutaka, Nouso, Kazuhiro, Kato, Hironari, Miyahara, Koji, Dohi, Chihiro, Morimoto, Yuki, Kinugasa, Hideaki, Tomoda, Takeshi, Yamamoto, Naoki, Tsutsumi, Koichiro, Kuwaki, Kenji, Onishi, Hideki, Ikeda, Fusao, Nakamura, Shinichiro, Shiraha, Hidenori, Takaki, Akinobu, Okada, Hiroyuki, Amano, Maho, Nishimura, Shin-Ichiro, and Yamamoto, Kazuhide

Published
2015
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7. Use of non-invasive serum glycan markers to distinguish non-alcoholic steatohepatitis from simple steatosis

Author

Yamasaki, Yasushi, Nouso, Kazuhiro, Miyahara, Koji, Wada, Nozomu, Dohi, Chihiro, Morimoto, Yuki, Kinugasa, Hideaki, Takeuchi, Yasuto, Yasunaka, Tetsuya, Kuwaki, Kenji, Onishi, Hideki, Ikeda, Fusao, Miyake, Yasuhiro, Nakamura, Shinichiro, Shiraha, Hidenori, Takaki, Akinobu, Iwasaki, Yoshiaki, Amano, Maho, Nishimura, Shin-Ichiro, and Yamamoto, Kazuhide

Published
2015
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9. Clinical utility of a serum glycome analysis in patients with colorectal cancer.

Author

Takei, Daisuke, Harada, Keita, Nouso, Kazuhiro, Miyahara, Koji, Dohi, Chihiro, Matsushita, Hiroshi, Kinugasa, Hideaki, Hiraoka, Sakiko, Nishimura, Shin‐Ichiro, and Okada, Hiroyuki

Subjects
BLOOD serum analysis, COLORECTAL cancer, RECEIVER operating characteristic curves, CANCER patients, CARCINOEMBRYONIC antigen
Abstract

Background and Aim: Serum glycans are known to be good markers for the early diagnosis and prognostic prediction in many cancers. The aims of this study were to reveal the serum glycan changes comprehensively during the process of carcinogenesis from colorectal adenoma (CRA) to colorectal cancer (CRC) and to evaluate the usefulness of the glycan profiles as clinical markers for CRC. Methods: Serum samples were obtained from 80 histologically proven CRC and 36 CRA cases. The levels of glycans in the serum were examined with a comprehensive, quantitative, high‐throughput unique glycome analysis, and their diagnostic and prognostic abilities were evaluated. Results: Among 34 stably detected glycans, nine were differentially expressed between CRC and CRA. Serum levels of hybrid type glycans were increased in patients with CRC compared with those with CRA (P < 0.001), and both hybrid‐type and multi‐antennary glycans were significantly increased in advanced cancer cases. The glycan, m/z 1914, showed the highest diagnostic value among the decreased glycans, whereas m/z 1708 showed the highest among the increased glycans. The glycan ratio m/z 1708/1914 showed a higher area under the receiver operating characteristic curve (0.889) than any other single glycan or conventional tumor marker, such as carcinoembryonic antigen (0.766, P = 0.040) and carbohydrate antigen 19‐9 (0.615, P < 0.001). High m/z 1708/1914 was also correlated with an advanced cancer stage and short overall survival. Conclusion: Serum glycans, especially the m/z 1708/1914 ratio, were useful for the diagnosis, staging, and prognosis prediction of CRC. [ABSTRACT FROM AUTHOR]

Published
2022
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11. Simple screening method for the diagnosis of nonB-nonC hepatocellular carcinoma

Author

Nouso, Kazuhiro, primary, Furubayashi, Yoshie, additional, Shiota, Shohei, additional, Wakuta, Akiko, additional, Oonishi, Ayano, additional, Kariyama, Kazuya, additional, Takeuchi, Yasuto, additional, Wada, Nozomu, additional, Onishi, Hideki, additional, Adachi, Takuya, additional, Oyama, Atsushi, additional, Dohi, Chihiro, additional, Yasunaka, Tetsuya, additional, Yasunaka, Yuki, additional, Ikeda, Fusao, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, and Okada, Hiroyuki, additional

Published
2018
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13. Suitable Liquid Biopsy Samples for Detecting Kras Mutations in Patients with Pancreatic Cancer

Author

Ako, Soichiro, primary, Nouso, Kazuhiro, additional, Kinugasa, Hideaki, additional, Dohi, Chihiro, additional, Matsushita, Hiroshi, additional, Mizukawa, Sho, additional, Muro, Shinichiro, additional, Akimoto, Yutaka, additional, Uchida, Daisuke, additional, Tomoda, Takeshi, additional, Matsumoto, Kazuyuki, additional, Horiguchi, Shigeru, additional, Tsutsumi, Koichiro, additional, Kato, Hironari, additional, and Okada, Hiroyuki, additional

Published
2017
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14. Monitoring serum proangiogenic cytokines from hepatocellular carcinoma patients treated with sorafenib.

Author

Adachi, Takuya, Nouso, Kazuhiro, Miyahara, Koji, Oyama, Atsushi, Wada, Nozomu, Dohi, Chihiro, Takeuchi, Yasuto, Yasunaka, Tetsuya, Onishi, Hideki, Ikeda, Fusao, Nakamura, Shinichiro, Shiraha, Hidenori, Takaki, Akinobu, Takabatake, Hiroyuki, Fujioka, Shin‐ichi, Kobashi, Haruhiko, Takuma, Yoshitaka, Iwadou, Shouta, Uematsu, Shuji, and Takaguchi, Koichi

Subjects
HEPATITIS B, HEPATOCYTE growth factor, HEPATITIS associated antigen, HEPATOCELLULAR carcinoma, CYTOKINES, ANGIOPOIETIN-2
Abstract

Background and Aim: Several factors, including proangiogenic cytokines, have been reported as predictive markers for the treatment effect of sorafenib in patients with hepatocellular carcinoma (HCC); however, most of them were determined based on one‐time measurements before treatment. Methods: We consecutively recruited 80 advanced HCC patients who were treated with sorafenib prospectively. Serum levels of eight proangiogenic cytokines and the appearance of adverse events were monitored periodically, and their correlations with the prognoses of the patients were evaluated. Results: Among six significant risk factors for overall survival in univariate analyses, high angiopoietin‐2 (hazard ratio, 2.06), high hepatocyte growth factor (hazard ratio, 2.08), and poor performance status before the treatment (hazard ratio, 2.48) were determined as independent risk factors. In addition, high angiopoietin‐2 at the time of progressive disease was a marker of short post‐progression survival (hazard ratio, 4.27). However, there was no significant variable that predicted short progression‐free survival except the presence of hepatitis B virus surface antigen. Conclusions: Predictions of overall survival and post‐progression survival were possible by periodically measuring serum proangiogenic cytokines, especially angiopoietin‐2, in patients with HCC treated with sorafenib. [ABSTRACT FROM AUTHOR]

Published
2019
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15. Su2023 Changes of Immunoglobulin-Bound Glycans in Patients With Gastro-Intestinal Cancers

Author

Dohi, Chihiro, primary, Nouso, Kazuhiro, additional, Ako, Soichiro, additional, Morimoto, Yuuki, additional, Miyahara, Koji, additional, Kinugasa, Hideaki, additional, Wada, Nozomu, additional, Takeuchi, Yasuto, additional, Kuwaki, Kenji, additional, Onishi, Hideki, additional, Ikeda, Fusao, additional, Nakamura, Shinichiro, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, and Okada, Hiroyuki, additional

Published
2016
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16. Tu1625 Characteristics of HCC Patients With hTERT Promoter Mutation

Author

Ako, Soichiro, primary, Nouso, Kazuhiro, additional, Kinugasa, Hideaki, additional, Adachi, Takuya, additional, Dohi, Chihiro, additional, Morimoto, Yuuki, additional, Wada, Nozomu, additional, Takeuchi, Yasuto, additional, Kuwaki, Kenji, additional, Onishi, Hideki, additional, Ikeda, Fusao, additional, Nakamura, Shinichiro, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, Fujioka, Shinichi, additional, and Okada, Hiroyuki, additional

Published
2016
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17. Potential of alpha‐fetoprotein as a prognostic marker after curative radiofrequency ablation of hepatocellular carcinoma

Author

Dohi, Chihiro, primary, Nouso, Kazuhiro, additional, Miyahara, Koji, additional, Morimoto, Yuki, additional, Wada, Nozomu, additional, Kinugasa, Hideaki, additional, Takeuchi, Yasuto, additional, Kuwaki, Kenji, additional, Onishi, Hideki, additional, Ikeda, Fusao, additional, Nakamura, Shinichiro, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, and Okada, Hiroyuki, additional

Published
2016
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19. Su1459 Serum N-Glycan Profiles in Patients With Intraductal Papillary Mucinous Neoplasms of Pancreas

Author

Akimoto, Yutaka, primary, Nouso, Kazuhiro, additional, Kato, Hironari, additional, Miyahara, Koji, additional, Dohi, Chihiro, additional, Morimoto, Yuki, additional, Kinugasa, Hideaki, additional, Tomoda, Takeshi, additional, Yamamoto, Naoki, additional, Tsutsumi, Koichiro, additional, Nakamura, Shinichiro, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, Okada, Hiroyuki, additional, Amano, Maho, additional, Nishimura, Shin-Ichiro, additional, and Yamamoto, Kazuhide, additional

Published
2015
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20. Sa1844 Alteration of Serum N-Glycan Profile in Patients With Hepatocellular Carcinoma and Their Clinical Application

Author

Nouso, Kazuhiro, primary, Miyahara, Koji, additional, Dohi, Chihiro, additional, Morimoto, Yuki, additional, Kinugasa, Hideaki, additional, Wada, Nozomu, additional, Takeuchi, Yasuto, additional, Kuwaki, Kenji, additional, Onishi, Hideki, additional, Ikeda, Fusao, additional, Nakamura, Shinichiro, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, Amano, Maho, additional, Nishimura, Shin-Ichiro, additional, and Yamamoto, Kazuhide, additional

Published
2015
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22. Alteration ofN-glycan profiles in patients with chronic hepatitis and hepatocellular carcinoma

Author

Miyahara, Koji, primary, Nouso, Kazuhiro, additional, Dohi, Chihiro, additional, Morimoto, Yuki, additional, Kinugasa, Hideaki, additional, Wada, Nozomu, additional, Takeuchi, Yasuto, additional, Kuwaki, Kenji, additional, Onishi, Hideki, additional, Ikeda, Fusao, additional, Miyake, Yasuhiro, additional, Nakamura, Shinichiro, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, Amano, Maho, additional, Nishimura, Shin-Ichiro, additional, and Yamamoto, Kazuhide, additional

Published
2015
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24. Transcatheter Arterial Chemoembolization to Reduce Size of Hepatocellular Carcinoma before Radiofrequency Ablation.

Author

Ako S, Nakamura S, Nouso K, Dohi C, Wada N, Morimoto Y, Takeuchi Y, Yasunaka T, Kuwaki K, Onishi H, Ikeda F, Shiraha H, Takaki A, and Okada H

Subjects
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Retrospective Studies, Carcinoma, Hepatocellular therapy, Catheter Ablation, Chemoembolization, Therapeutic, Liver Neoplasms therapy
Abstract

Transcatheter arterial chemoembolization (TACE) is often performed before radiofrequency ablation (RFA) for the treatment of early-stage hepatocellular carcinoma (HCC). TACE prior to RFA can expand the ablated area and reduce the tumor size, facilitating complete ablation. However, the factors correlated with size reduction remain uncertain. The aim of this study was to identify the factors associated with size reduction by TACE and develop a formula to predict the reduction rate. A total of 100 HCC patients treated with TACE followed by RFA at least 20 days later were enrolled. The tumor size was measured at the time of TACE and RFA, and correlations between the reduction rate and 13 clinical factors were examined. A formula to predict the reduction rate was built using the factors obtained by the analysis. Reduction in the tumor size was observed in 69 nodules, and the median reduction rate was 16.2%. A multivariate regression analysis revealed that a large tumor size (p< 0.01) and a long interval between the therapies (p= 0.01) were factors for a high tumor reduction rate, with tumor size more strongly related to the degree of reduction. A size reduction of more than 10% can be expected by waiting 20 days after TACE when the size of the tumor at TACE is over 25 mm in diameter. The tumor size., Competing Interests: No potential conflict of interest relevant to this article was reported.

Published
2018
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