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1. TLABs: A Teaching and Learning Community of Practice -- What Is It, Does It Work and Tips for Doing One of Your Own

Author

Beatty, Shelley, Clark, Kim, Lines, Jo, and Doherty, Sally-Anne

Abstract

Communities of Practice are an increasingly common tool used to support novice academics in higher education settings. Initiated in 2015 at a Western Australian University, TLABs is an acronym for 'Teaching and Learning for Level A and B' academic staff and was designed to build a community of practice to mentor junior academics; help them develop their teaching skills; and enhance academic careers. The paper describes the nature of TLABs; how it is experienced from the perspective of participants and provides recommendations for implementing a successful teaching and learning community of practice in a higher education setting.

Published
2020

2. A Practical Look at the Why and How of Supporting International Students: A Checklist of Teaching Tips

Author

Beatty, Shelley, Clark, Kim, and Doherty, Sally-Anne

Abstract

This paper looks at a pilot of a strategy designed to help academic staff better respond to the inclusive teaching needs of its international students. The strategy was implemented by a School in a Western Australian University and offered academic staff evidence-based information on specific techniques for internationalising curriculum content and delivery. The extent to which international students perceived lecturers had implemented the suggested strategies was subsequently evaluated. While the evaluation found the School had performed adequately in the eyes of its international students across key areas of teaching practice, it also suggested that achieving greater inclusiveness required attention to things beyond classroom processes. These broader aspects included the University's climate of belongingness and the extent to which the curriculum content took account of international perspectives.

Published
2020

4. Exploring the Lived Experience of faculty implementing case-based learning: A Phenomenological Study

Author

Delany, Caroline, primary, Illing, Jan, additional, McIlroy, Marie, additional, Daly, Ronan, additional, Bruen, Catherine, additional, Alamuddin, Naji, additional, Condron, Clare, additional, Crehan, Martina, additional, Doherty, Sally, additional, Meagher, Frances, additional, Offiah, Gozie, additional, O’Neill, Sarah, additional, Stuart, Ellen, additional, Torrens, Christopher, additional, and Morgan, Maria P., additional

Published
2024
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5. Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis.

Author

Castaño-Betancourt, Martha C, Evans, Dan S, Ramos, Yolande FM, Boer, Cindy G, Metrustry, Sarah, Liu, Youfang, den Hollander, Wouter, van Rooij, Jeroen, Kraus, Virginia B, Yau, Michelle S, Mitchell, Braxton D, Muir, Kenneth, Hofman, Albert, Doherty, Michael, Doherty, Sally, Zhang, Weiya, Kraaij, Robert, Rivadeneira, Fernando, Barrett-Connor, Elizabeth, Maciewicz, Rose A, Arden, Nigel, Nelissen, Rob GHH, Kloppenburg, Margreet, Jordan, Joanne M, Nevitt, Michael C, Slagboom, Eline P, Hart, Deborah J, Lafeber, Floris, Styrkarsdottir, Unnur, Zeggini, Eleftheria, Evangelou, Evangelos, Spector, Tim D, Uitterlinden, Andre G, Lane, Nancy E, Meulenbelt, Ingrid, Valdes, Ana M, and van Meurs, Joyce BJ

Subjects
Cartilage, Hip Joint, Humans, Osteoarthritis, Hip, Genetic Predisposition to Disease, Trehalase, Transforming Growth Factor alpha, Regulatory Sequences, Nucleic Acid, Genetic Heterogeneity, Polymorphism, Single Nucleotide, Aged, Aged, 80 and over, Middle Aged, Female, Male, Receptor, Fibroblast Growth Factor, Type 3, Genome-Wide Association Study, Phosphatidylinositol 3-Kinases, Class Ia Phosphatidylinositol 3-Kinase, Osteoarthritis, Hip, Regulatory Sequences, Nucleic Acid, Polymorphism, Single Nucleotide, and over, Receptor, Fibroblast Growth Factor, Type 3, Genetics, Developmental Biology
Abstract

Osteoarthritis is one of the most frequent and disabling diseases of the elderly. Only few genetic variants have been identified for osteoarthritis, which is partly due to large phenotype heterogeneity. To reduce heterogeneity, we here examined cartilage thickness, one of the structural components of joint health. We conducted a genome-wide association study of minimal joint space width (mJSW), a proxy for cartilage thickness, in a discovery set of 13,013 participants from five different cohorts and replication in 8,227 individuals from seven independent cohorts. We identified five genome-wide significant (GWS, P≤5·0×10-8) SNPs annotated to four distinct loci. In addition, we found two additional loci that were significantly replicated, but results of combined meta-analysis fell just below the genome wide significance threshold. The four novel associated genetic loci were located in/near TGFA (rs2862851), PIK3R1 (rs10471753), SLBP/FGFR3 (rs2236995), and TREH/DDX6 (rs496547), while the other two (DOT1L and SUPT3H/RUNX2) were previously identified. A systematic prioritization for underlying causal genes was performed using diverse lines of evidence. Exome sequencing data (n = 2,050 individuals) indicated that there were no rare exonic variants that could explain the identified associations. In addition, TGFA, FGFR3 and PIK3R1 were differentially expressed in OA cartilage lesions versus non-lesioned cartilage in the same individuals. In conclusion, we identified four novel loci (TGFA, PIK3R1, FGFR3 and TREH) and confirmed two loci known to be associated with cartilage thickness.The identified associations were not caused by rare exonic variants. This is the first report linking TGFA to human OA, which may serve as a new target for future therapies.

Published
2016

7. Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis.

Author

Evans, Daniel S, Cailotto, Frederic, Parimi, Neeta, Valdes, Ana M, Castaño-Betancourt, Martha C, Liu, Youfang, Kaplan, Robert C, Bidlingmaier, Martin, Vasan, Ramachandran S, Teumer, Alexander, Tranah, Gregory J, Nevitt, Michael C, Cummings, Steven R, Orwoll, Eric S, Barrett-Connor, Elizabeth, Renner, Jordan B, Jordan, Joanne M, Doherty, Michael, Doherty, Sally A, Uitterlinden, Andre G, van Meurs, Joyce BJ, Spector, Tim D, Lories, Rik J, and Lane, Nancy E

Subjects
Humans, Osteoarthritis, Hip, Genetic Predisposition to Disease, Insulin-Like Growth Factor Binding Protein 3, Case-Control Studies, Osteogenesis, Chondrogenesis, Polymorphism, Single Nucleotide, Aged, Aged, 80 and over, Middle Aged, Male, Genome-Wide Association Study, Chondrocytes, Epidemiology, Gene Polymorphism, Osteoarthritis, Arthritis & Rheumatology, Clinical Sciences, Immunology, Public Health and Health Services
Abstract

ObjectivesTo identify genetic associations with hip osteoarthritis (HOA), we performed a meta-analysis of genome-wide association studies (GWAS) of HOA.MethodsThe GWAS meta-analysis included approximately 2.5 million imputed HapMap single nucleotide polymorphisms (SNPs). HOA cases and controls defined radiographically and by total hip replacement were selected from the Osteoporotic Fractures in Men (MrOS) Study and the Study of Osteoporotic Fractures (SOF) (654 cases and 4697 controls, combined). Replication of genome-wide significant SNP associations (p ≤5×10(-8)) was examined in five studies (3243 cases and 6891 controls, combined). Functional studies were performed using in vitro models of chondrogenesis and osteogenesis.ResultsThe A allele of rs788748, located 65 kb upstream of the IGFBP3 gene, was associated with lower HOA odds at the genome-wide significance level in the discovery stage (OR 0.71, p=2×10(-8)). The association replicated in five studies (OR 0.92, p=0.020), but the joint analysis of discovery and replication results was not genome-wide significant (p=1×10(-6)). In separate study populations, the rs788748 A allele was also associated with lower circulating IGFBP3 protein levels (p=4×10(-13)), suggesting that this SNP or a variant in linkage disequilibrium could be an IGFBP3 regulatory variant. Results from functional studies were consistent with association results. Chondrocyte hypertrophy, a deleterious event in OA pathogenesis, was largely prevented upon IGFBP3 knockdown in chondrocytes. Furthermore, IGFBP3 overexpression induced cartilage catabolism and osteogenic differentiation.ConclusionsResults from GWAS and functional studies provided suggestive links between IGFBP3 and HOA.

Published
2015

16. Understanding communication of health information: a lesson in health literacy for junior medical and physiotherapy students

Author

Doyle, Frank, Doherty, Sally, Morgan, Karen, McBride, Orla, and Hickey, Anne

Subjects
FOS: Psychology, Other psychology not elsewhere classified, Comunication, 179999 Psychology and Cognitive Sciences not elsewhere classified, Psychology and Cognitive Sciences not elsewhere classified, Students, Health Literacy
Abstract

Communicating health information is a core skill required of all health care professionals. However, the ability of the recipient to understand the information provided – health literacy – is critical (Baker, 2006), yet receives relatively less attention in health professional teaching and training. The most commonly used method of communicating health information to patients and the general public is through use of patient information leaflets (PILs) (Pander Maat and Lentz, 2010). It is vital that these are designed in an optimal manner, taking at least three key principles into account: 1.They should have a low reading age, ensuring that the average reader can read and comprehend PIL content (Williamson and Martin, 2010). 2.PILs should utilise theories of health behaviour to maximise their motivational effects and provide practical assistance to the reader to adhere to the PIL’s recommendations (e.g. Armitage and Conner, 2000). 3.They should be accurate, contain enough detail, and not be biased by companies who sponsor the information (Charnock et al., 1999).

Published
2022
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17. Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis

Author

Betancourt, Martha C. Castaño, Cailotto, Frederic, Kerkhof, Hanneke J., Cornelis, Frederique M. F., Doherty, Sally A., Hart, Deborah J., Hofman, Albert, Luyten, Frank P., Maciewicz, Rose A., Mangino, Massimo, Metrustry, Sarah, Muir, Kenneth, Peters, Marjolein J., Rivadeneira, Fernando, Wheeler, Maggie, Zhang, Weiya, Arden, Nigel, Spector, Tim D., Uitterlinden, Andre G., Doherty, Michael, Lories, Rik J. U., Valdes, Ana M., and van Meurs, Joyce B. J.

Published
2012

18. Assessing medical mistrust in organ donation across countries using item response theory

Author

Ghoshal, Arunangshu, Ferguson, Eamonn, Shepherd, Lee, Doherty, Sally, Mathew, Mary, Morgan, Karen, and Doyle, Frank

Subjects
Applied Psychology
Abstract

Although medical mistrust (MM) may be an impediment to public health interventions, no MM scale has been validated across countries and the assessment of MM has not been explored using item response theory, which allows generalisation beyond the sampled data. We aimed to determine the dimensionality of a brief MM measure across four countries through Mokken analysis and Graded Response Modelling. Analysis of 1468 participants from UK (n = 1179), Ireland (n = 191), India (n = 49) and Malaysia (n = 49) demonstrated that MM items formed a hierarchical, unidimensional measure, which is very informative about high levels of MM. Possible item reduction and scoring changes were also demonstrated. This study demonstrates that this brief MM measure is suitable for international studies as it is unidimensional across countries, cross cultural, and shows that minor adjustments will not impact on the assessment of MM when using these items.

Published
2021

19. Assessing medical mistrust in organ donation across countries using item response theory.

Author

Ghoshal, Arunangshu, O'Carroll, Ronan E, Ferguson, Eamonn, Shepherd, Lee, Doherty, Sally, Mathew, Mary, Morgan, Karen, and Doyle, Frank

Subjects
MEDICAL mistrust, RESEARCH methodology, PSYCHOMETRICS, PATIENT-professional relations, ORGAN donation, PUBLIC opinion, ORGAN donors
Abstract

Although medical mistrust (MM) may be an impediment to public health interventions, no MM scale has been validated across countries and the assessment of MM has not been explored using item response theory, which allows generalisation beyond the sampled data. We aimed to determine the dimensionality of a brief MM measure across four countries through Mokken analysis and Graded Response Modelling. Analysis of 1468 participants from UK (n = 1179), Ireland (n = 191), India (n = 49) and Malaysia (n = 49) demonstrated that MM items formed a hierarchical, unidimensional measure, which is very informative about high levels of MM. Possible item reduction and scoring changes were also demonstrated. This study demonstrates that this brief MM measure is suitable for international studies as it is unidimensional across countries, cross cultural, and shows that minor adjustments will not impact on the assessment of MM when using these items. [ABSTRACT FROM AUTHOR]

Published
2022
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23. sj-pdf-1-hpq-10.1177_13591053211064985 ��� Supplemental material for Assessing medical mistrust in organ donation across countries using item response theory

Author

Ghoshal, Arunangshu, O���Carroll, Ronan E, Ferguson, Eamonn, Shepherd, Lee, Doherty, Sally, Mathew, Mary, Morgan, Karen, and Doyle, Frank

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 111799 Public Health and Health Services not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), FOS: Health sciences
Abstract

Supplemental material, sj-pdf-1-hpq-10.1177_13591053211064985 for Assessing medical mistrust in organ donation across countries using item response theory by Arunangshu Ghoshal, Ronan E O���Carroll, Eamonn Ferguson, Lee Shepherd, Sally Doherty, Mary Mathew, Karen Morgan and Frank Doyle in Journal of Health Psychology

Published
2021
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28. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis

Author

Valdes, Ana M., Loughlin, John, Timms, Kirsten M., van Meurs, Joyce J.B., Southam, Lorraine, Wilson, Scott G, Doherty, Sally, Lories, Rik J., Luyten, Frank P., Gutin, Alexander, Abkevich, Victor, Dongliang Ge, Hofman, Albert, Uitterlinden, Andre G., Hart, Deborah J., Feng Zhang, Zhai, Guangju, Spector, Tim D., Lanchbury, Jerry, Doherty, Michael, and Egli, Rainer J.

Subjects
Osteoarthritis -- Genetic aspects, Single nucleotide polymorphisms -- Analysis, Genomics -- Research, Gene expression -- Analysis, Biological sciences
Abstract

A large-coverage pooled genome-wide association scan (GWAS) of knee osteoarthritis (OA) and the results from successive test of individual most highly associated single-nucleotide polymorphisms (SNPs) in five case-control studies are reported. Findings show that polymorphism in LD with variants affecting the expression of the PTGS2 gene are associated with susceptibility to knee OA in five independent populations and highlight the importance of inflammatory pathways in OA pathogenesis.

Published
2008

29. The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males

Author

Evangelou, Evangelos, Valdes, Ana M, Castano-Betancourt, Martha C, Doherty, M, Doherty, Sally, Esko, Tonu, Ingvarsson, Thorvaldur, Ioannidis, John P A, Kloppenburg, Margreet, Metspalu, Andres, Ntzani, Evangelia E, Panoutsopoulou, Kalliope, Slagboom, P Eline, Southam, Lorraine, Spector, Tim D, Styrkarsdottir, Unnur, Stefanson, Kari, Uitterlinden, André G, Wheeler, Margaret, Zeggini, Eleftheria, Meulenbelt, Ingrid, and van Meurs, Joyce B

Published
2013
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31. A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype

Author

Malfait, Anne-Marie, Seymour, Albert B, Gao, Feng, Tortorella, Micky D, Le Graverand-Gastineau, Marie-Pierre Hellio, Wood, Linda S, Doherty, Michael, Doherty, Sally, Zhang, Weiya, Arden, Nigel K, Vaughn, Frances L, Leaverton, Paul E, Spector, Tim D, Hart, Deborah J, Maciewicz, Rose A, Muir, Kenneth R, Das, Rosalina, Sorge, Robert E, Sotocinal, Susanna G, Schorscher-Petcu, Ara, Valdes, Ana M, and Mogil, Jeffrey S

Published
2012
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33. The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis

Author

Valdes, Ana M, De Wilde, Gert, Doherty, Sally A, Lories, Rik J, Vaughn, Frances L, Laslett, Laura L, Maciewicz, Rose A, Soni, Anushka, Hart, Deborah J, Zhang, Weiya, Muir, Kenneth R, Dennison, Elaine M, Wheeler, Margaret, Leaverton, Paul, Cooper, Cyrus, Spector, Tim D, Cicuttini, Flavia M, Chapman, Victoria, Jones, Graeme, Arden, Nigel K, and Doherty, Michael

Published
2011
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34. The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance

Author

Valdes, Ana M, Evangelou, Evangelos, Kerkhof, Hanneke J M, Tamm, Agu, Doherty, Sally A, Kisand, Kalle, Tamm, Ann, Kerna, Irina, Uitterlinden, Andre, Hofman, Albert, Rivadeneira, Fernando, Cooper, Cyrus, Dennison, Elaine M, Zhang, Weiya, Muir, Kenneth R, Ioannidis, John P A, Wheeler, Margaret, Maciewicz, Rose A, van Meurs, Joyce B, Arden, Nigel K, Spector, Tim D, and Doherty, Michael

Published
2011
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35. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

Author

Evangelou, Evangelos, Valdes, Ana M, Kerkhof, Hanneke J M, Styrkarsdottir, Unnur, Zhu, YanYan, Meulenbelt, Ingrid, Lories, Rik J, Karassa, Fotini B, Tylzanowski, Przemko, Bos, Steffan D, Akune, Toru, Arden, Nigel K, Carr, Andrew, Chapman, Kay, Cupples, L Adrienne, Dai, Jin, Deloukas, Panos, Doherty, Michael, Doherty, Sally, Engstrom, Gunnar, Gonzalez, Antonio, Halldorsson, Bjarni V, Hammond, Christina L, Hart, Deborah J, Helgadottir, Hafdis, Hofman, Albert, Ikegawa, Shiro, Ingvarsson, Thorvaldur, Jiang, Qing, Jonsson, Helgi, Kaprio, Jaakko, Kawaguchi, Hiroshi, Kisand, Kalle, Kloppenburg, Margreet, Kujala, Urho M, Lohmander, L Stefan, Loughlin, John, Luyten, Frank P, Mabuchi, Akihiko, McCaskie, Andrew, Nakajima, Masahiro, Nilsson, Peter M, Nishida, Nao, Ollier, William E R, Panoutsopoulou, Kalliope, van de Putte, Tom, Ralston, Stuart H, Rivadeneira, Fernado, Saarela, Janna, Schulte-Merker, Stefan, Shi, Dongquan, Slagboom, P Eline, Sudo, Akihiro, Tamm, Agu, Tamm, Ann, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tsezou, Aspasia, Wallis, Gillian A, Wilkinson, J Mark, Yoshimura, Noriko, Zeggini, Eleftheria, Zhai, Guangju, Zhang, Feng, Jonsdottir, Ingileif, Uitterlinden, Andre G, Felson, David T, van Meurs, Joyce B, Stefansson, Kari, Ioannidis, John P A, and Spector, Timothy D

Published
2011
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39. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22

Author

Kerkhof, Hanneke J. M., Lories, Rik J., Meulenbelt, Ingrid, Jonsdottir, Ingileif, Valdes, Ana M., Arp, Pascal, Ingvarsson, Thorvaldur, Jhamai, Mila, Jonsson, Helgi, Stolk, Lisette, Thorleifsson, Gudmar, Zhai, Guangju, Zhang, Feng, Zhu, Yanyan, van der Breggen, Ruud, Carr, Andrew, Doherty, Michael, Doherty, Sally, Felson, David T., Gonzalez, Antonio, Halldorsson, Bjarni V., Hart, Deborah J., Hauksson, Valdimar B., Hofman, Albert, Ioannidis, John P. A., Kloppenburg, Margreet, Lane, Nancy E., Loughlin, John, Luyten, Frank P., Nevitt, Michael C., Parimi, Neeta, Pols, Huibert A. P., Rivadeneira, Fernando, Slagboom, Eline P., Styrkársdóttir, Unnur, Tsezou, Aspasia, van de Putte, Tom, Zmuda, Joseph, Spector, Tim D., Stefansson, Kari, Uitterlinden, André G., and van Meurs, Joyce B. J.

Published
2010
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41. Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand

Author

Evangelou, Evangelos, Chapman, Kay, Meulenbelt, Ingrid, Karassa, Fotini B., Loughlin, John, Carr, Andrew, Doherty, Michael, Doherty, Sally, Gómez-Reino, Juan J., Gonzalez, Antonio, Halldorsson, Bjarni V., Hauksson, Valdimar B., Hofman, Albert, Hart, Deborah J., Ikegawa, Shiro, Ingvarsson, Thorvaldur, Jiang, Qing, Jonsdottir, Ingileif, Jonsson, Helgi, Kerkhof, Hanneke J. M., Kloppenburg, Margreet, Lane, Nancy E., Li, Jia, Lories, Rik J., van Meurs, Joyce B. J., Näkki, Annu, Nevitt, Michael C., Rodriguez-Lopez, Julio, Shi, Dongquan, Slagboom, Eline P., Stefansson, Kari, Tsezou, Aspasia, Wallis, Gillian A., Watson, Christopher M., Spector, Tim D., Uitterlinden, Andre G., Valdes, Ana M., and Ioannidis, John P. A.

Published
2009
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47. Additional file 2: of The CHARMS pilot study: a multi-method assessment of the feasibility of a sexual counselling implementation intervention in cardiac rehabilitation in Ireland

Author

Murphy, Patrick, Noone, Chris, D’Eath, Maureen, Casey, Dympna, Doherty, Sally, Jaarsma, Tiny, Murphy, Andrew, O’Donnell, Martin, Fallon, Noeleen, Gillespie, Paddy, Amirhossein Jalali, Sharry, Jenny, Newell, John, Toomey, Elaine, Steinke, Elaine, and Byrne, Molly

Abstract

Application of ADePT process to patient attrition. (DOCX 19Â kb)

Published
2018
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48. Additional file 1: of The CHARMS pilot study: a multi-method assessment of the feasibility of a sexual counselling implementation intervention in cardiac rehabilitation in Ireland

Author

Murphy, Patrick, Noone, Chris, D’Eath, Maureen, Casey, Dympna, Doherty, Sally, Jaarsma, Tiny, Murphy, Andrew, O’Donnell, Martin, Fallon, Noeleen, Gillespie, Paddy, Amirhossein Jalali, Sharry, Jenny, Newell, John, Toomey, Elaine, Steinke, Elaine, and Byrne, Molly

Abstract

CHARMS CONSORT Extension Checklist. (DOC 226Â kb)

Published
2018
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50. Additional file 3: of The CHARMS pilot study: a multi-method assessment of the feasibility of a sexual counselling implementation intervention in cardiac rehabilitation in Ireland

Author

Murphy, Patrick, Noone, Chris, D’Eath, Maureen, Casey, Dympna, Doherty, Sally, Jaarsma, Tiny, Murphy, Andrew, O’Donnell, Martin, Fallon, Noeleen, Gillespie, Paddy, Amirhossein Jalali, Sharry, Jenny, Newell, John, Toomey, Elaine, Steinke, Elaine, and Byrne, Molly

Abstract

Application of ADePT process to staff perceptions. (DOCX 14Â kb)

Published
2018
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