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3. Health, social and economic implications of adolescent risk behaviours/states: protocol for Raine Study Gen2 cohort data linkage study

Author

Marino, Jennifer L., Tait, Robert J., Straker, Leon M., Schofield, Deborah J., Doherty, Dorota A., Ivers, Rebecca Q., Graham, Petra L., Steinbeck, Katharine, Lymer, Sharyn, Sanci, Lena A., Patton, George C., Liu, Bette, Brooks, Fiona M., Kang, Melissa S., Hickey, Martha, Cunich, Michelle, Bista, Sarita, and Skinner, S. Rachel

Published
2022
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5. Perinatal mortality among term births: Informing decisions about singleton early term births in Western Australia.

Author

Berman, Ye'elah E., Newnham, John P., Nathan, Elizabeth A., Doherty, Dorota A., Brown, Kiarna, and Ward, Sarah V.

Subjects
PERINATAL death, PREGNANT women, INDIGENOUS women, NEONATAL death, STILLBIRTH
Abstract

Background: To minimise the risk of perinatal mortality, clinicians and expectant mothers must understand the risks and benefits associated with continuing the pregnancy. Objectives: Report the gestation‐specific risk of perinatal mortality at term. Methods: Population‐based cohort study using linked health data to identify all singleton births at gestations 37–41 weeks, in Western Australia (WA) from 2009 to 2019. Lifetable analysis was used to combine the risk of each type of perinatal mortality and calculate the cumulative risk of perinatal mortality, termed the perinatal risk index (PRI). Rates of antepartum and intrapartum stillbirth and neonatal death, as well as the PRI, were examined for each gestational week at term by non‐Aboriginal and Aboriginal ethnicity. For non‐Aboriginal women, rates were also examined by time‐period (pre‐ vs. post‐WA Preterm Birth Prevention Initiative (the Initiative) rollout), primiparity, and obstetric risk. Results: There were 332,084 singleton term births, including 60 perinatal deaths to Aboriginal mothers (3.2 deaths per 1000 births to Aboriginal mothers) and 399 perinatal deaths to non‐Aboriginal mothers (1.3 deaths per 1000 births to non‐Aboriginal mothers). For non‐Aboriginal women, the PRI was at its lowest (PRI 0.80, 95% CI 0.61, 1.00) at 39 weeks gestation. For Aboriginal women, it was at its lowest at 38 weeks (PRI 2.43, 95% CI 0.48, 4.39) with similar risk at 39 weeks (PRI 2.68, 95% CI 1.22, 4.14). The PRI increased steadily after 39 weeks gestation. The risk of perinatal mortality was higher among Aboriginal women. The gestation‐specific perinatal mortality rates were similar by the time‐period, primiparity and obstetric risk. Conclusions: The gestational ages at term associated with the lowest risk of perinatal mortality reinforce that the recommendation not to deliver before 39 weeks without medical indication is applicable to both Aboriginal and non‐Aboriginal women giving birth in WA. There was no increase in the perinatal mortality rate associated with the introduction of the Initiative. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Health, social and economic implications of adolescent risk behaviours/states: protocol for Raine Study Gen2 cohort data linkage study

Author

Marino, Jennifer L, Tait, Robert J, Straker, Leon M, Schofield, Deborah J, Doherty, Dorota A, Ivers, Rebecca Q, Graham, Petra L, Steinbeck, Katharine, Lymer, Sharyn, Sanci, Lena A, Patton, George C, Liu, Bette, Brooks, Fiona M, Kang, Melissa S, Hickey, Martha, Cunich, Michelle, Bista, Sarita, and Skinner, S. Rachel

Published
2024
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26. Registry randomised trials: a methodological perspective

Author

Doherty, Dorota A, primary, Tong, Steven Y C, additional, Reilly, Jennifer, additional, Shrapnel, Jane, additional, McDonald, Stephen, additional, Ahern, Susannah, additional, Harris, Ian, additional, Tam, Charmaine S, additional, Brennan, Angela L, additional, Hodgson, Carol, additional, Wilcox, Leonie, additional, Balagurunathan, Anitha, additional, Butcher, Belinda E, additional, and Reid, Christopher M, additional

Published
2023
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31. Additional file 1 of The Western Australian preterm birth prevention initiative: a whole of state singleton pregnancy cohort study showing the need to embrace alternative models of care for Aboriginal women

Author

Berman, Ye’elah E., Newnham, John P., White, Scott W., Brown, Kiarna, and Doherty, Dorota A.

Abstract

Additional file 1: Supplementary Table 1. Rates of preterm birth for maternal characteristics known at the time of the first antenatal visit. Supplementary Table 2. Rates of PTB for maternal characteristics and pregnancy complications, by ethnicity and risk (2009–2019). Supplementary Table 3. Rates of stillbirth per 1000 singleton births, by year ethnicity and hospital.

Published
2023
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32. Associations between Prenatal Exposure to Phthalates and Features of the Metabolic Syndrome in Males from Childhood into Adulthood

Author

Berman, Ye’elah E., primary, Doherty, Dorota A., additional, Mori, Trevor A., additional, Beilin, Lawrence J., additional, Ayonrinde, Oyekoya T., additional, Adams, Leon A., additional, Huang, Rae-Chi, additional, Olynyk, John K., additional, Keelan, Jeffrey A., additional, Newnham, John P., additional, and Hart, Roger J., additional

Published
2022
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36. Associations between prenatal exposure to phthalates and features of the metabolic syndrome in males from childhood into adulthood

Author

Berman, Ye’elah E., Doherty, Dorota A., Mori, Trevor A., Beilin, Lawrence J., Ayonrinde, Oyekoya T., Adams, Leon A., Huang, Rae-Chi, Olynyk, John K., Keelan, Jeffrey A., Newnham, John P., Hart, Roger J., Berman, Ye’elah E., Doherty, Dorota A., Mori, Trevor A., Beilin, Lawrence J., Ayonrinde, Oyekoya T., Adams, Leon A., Huang, Rae-Chi, Olynyk, John K., Keelan, Jeffrey A., Newnham, John P., and Hart, Roger J.

Abstract

Phthalate metabolites are detectable within the majority of the population. Evidence suggests that a prenatal exposure to phthalates may be associated with the subsequent risks of obesity and elevated blood pressure. We hypothesised that a prenatal exposure to phthalates would lead to an increase in adverse cardiometabolic parameters through childhood and adulthood. The maternal serum phthalate measurements from the stored samples taken from Gen1 mothers at 18 and 34 weeks gestation were examined in relation to the cardiometabolic measures in 387 male offspring from the Raine Study. Data from the Gen2 follow-ups between 3 and 27 years were used. The primary outcomes were analysed longitudinally using linear mixed models for the repeated measures. Non-alcoholic fatty liver disease (NAFLD) was assessed at 17 years using logistic regression. A consistent positive relationship was observed between a prenatal exposure to mono-carboxy-iso-octyl phthalate (MCiOP) through adolescence into adulthood with systolic blood pressure. There were no other consistent cardiovascular associations. Mid-levels of prenatal exposures to Mono-n-butyl phthalate (MnBP) were associated with a greater incidence of NAFLD. Detectable Mono-3-carboxypropyl phthalate (MCPP) was associated with a lower serum HDL-C through late childhood into adulthood, while a higher prenatal exposure to mono-iso-butyl phthalate (MiBP), was associated with a higher LDL-C at 22 years of age. A mid-level prenatal exposure to mono-2-ethylhexyl phthalate (MEHP) metabolites was associated with higher insulin in adulthood, while a higher prenatal exposure to the sum of the Di-(2-ethyl-hexyl) phthalate (DEHP) and Di-iso-nonyl phthalate (DiNP) metabolites was associated with higher fasting serum glucose in adulthood. In conclusion, our study demonstrated that higher prenatal phthalate exposures to some phthalate metabolites was associated with some adverse metabolic profiles through adolescence into adulthood, although the

Published
2022

43. Effect of single versus multistrain probiotic in extremely preterm infants: a randomised trial

Author

Athalye-Jape, Gayatri, primary, Esvaran, Meera, additional, Patole, Sanjay, additional, Simmer, Karen, additional, Nathan, Elizabeth, additional, Doherty, Dorota, additional, Keil, Anthony, additional, Rao, Shripada, additional, Chen, Liwei, additional, Chandrasekaran, Lakshmi, additional, Kok, Chooi, additional, Schuster, Stephan, additional, and Conway, Patricia, additional

Published
2022
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47. Longitudinal effects of prenatal exposure to plastic‐derived chemicals and their metabolites on asthma and lung function from childhood into adulthood.

Author

Foong, Rachel E., Franklin, Peter, Sanna, Francesca, Hall, Graham L., Sly, Peter D., Thorstensen, Eric B., Doherty, Dorota A., Keelan, Jeffrey A., and Hart, Roger J.

Subjects
PRENATAL exposure, ASTHMA, LUNGS, ADULTS, QUANTILE regression
Abstract

Background and Objective: Environmental exposure to phthalates and bisphenol A (BPA), chemicals used in the production of plastics, may increase risk for asthma and allergies. However, little is known about the long‐term effects of early life exposure to these compounds. We investigated if prenatal exposure to these compounds was associated with asthma, allergy and lung function outcomes from early childhood into adulthood in a cohort study. Methods: Maternal serum samples collected from 846 pregnant women in the Raine Study were assayed for BPA and phthalate metabolites. The children of these women were followed up at 5, 13 and 22 years where spirometry and respiratory questionnaires were conducted to determine asthma and allergy status. Lung function trajectories were derived from longitudinal spirometry measurements. Multinomial logistic regression and weighted quantile sum regression was used to test associations of individual and chemical mixtures with asthma phenotypes and lung function trajectories. Results: Effects of prenatal BPA and phthalates on asthma phenotypes were seen in male offspring, where BPA was associated with increased risk for persistent asthma, while mono‐iso‐butyl phthalate and mono‐iso‐decyl phthalate was associated with increased risk for adult asthma. Prenatal BPA had no effect on lung function trajectories, but prenatal phthalate exposure was associated with improved lung function. Conclusion: Prenatal BPA exposure was associated with increased likelihood of persistent asthma in males, while prenatal phthalate exposure was associated with increased likelihood of adult asthma in males. Results suggest that prenatal exposure to prenatal BPA and phthalates affect asthma risk, particularly in males, however lung function was not adversely affected. [ABSTRACT FROM AUTHOR]

Published
2023
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