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Introduction: Canine tooth syndrome is a rare condition defined by the simultaneous presence of superior oblique palsy and Brown syndrome, resulting from pathological changes in the trochlear region. This syndrome can develop through various mechanisms, including dog bites, head trauma, infections, inflammation, and scarring. This report highlights its occurrence following sinus surgery for the first time. Methods: Medical and surgical records of an 18-year-old girl who presented with reading position diplopia after sinus surgery for right-side frontoethmoidal osteoma were retrospectively reviewed. Results: Strabismus examination revealed 8 Prism Diopter (PD) primary position hypertropia in the right eye that increased to 20 PD in downgaze. In the upward gaze to the left, the right eye showed 12 PD hypotropia with a positive forced duction test. The patient exhibited simultaneous signs of paresis and restriction of the right superior oblique muscle, consistent with type 7 of the Knapp classification. The patient declined strabismus surgery, and vertical diplopia was managed with prism spectacles. Long-term follow-up showed spontaneous resolution of superior oblique paresis leaving the patient with isolated Brown syndrome in the right eye. Discussion: Canine tooth syndrome can arise as a complication of frontoethmoidal sinus surgery due to excessive intraoperative manipulation of the superior and medial orbital wall, particularly in the trochlear region. [ABSTRACT FROM AUTHOR]

Objective: Rare disease Background: The bacterial organism Capnocytophaga canimorsus is an oral commensal of cats and dogs and can cause lifethreatening infections like mycotic aneurysm, meningitis, and sepsis. Mycotic aneurysms occur when microbial infections cause arterial wall degeneration. Difficulty in diagnosing Capnocytophaga canimorsus infection can occur due to the bacteria's fastidious nature and laboratory testing limitations, contributing to the infection's high morbidity and mortality. This report describes the case of a patient with an iliac artery mycotic aneurysm 2 months after a dog bite. Identification of Capnocytophaga canimorsus was achieved through polymerase chain reaction. Case Report: The 67-year-old female patient presented initially with nonspecific abdominal pain. Imaging revealed a right iliac artery abnormality suspicious for mycotic aneurysm. Capnocytophaga canimorsus was identified through broad-range bacterial polymerase chain reaction after standard culture failed to determine the infectious etiology. A history of dog bite was discovered after diagnosis. When standard culture cannot provide a diagnosis, 16s rRNA polymerase chain reaction is the preferred molecular-based test at our institution. Conclusions: Through presentation of a case of Capnocytophaga canimorsus mycotic aneurysm in an immunocompetent woman, this report illustrates the importance of familiarity with Capnocytophaga canimorsus and molecular laboratory methods in achieving favorable outcomes when faced with Capnocytophaga canimorsus infection. In these difficult cases, 16s rRNA polymerase chain reaction and similar molecular technologies are becoming essential. This case also highlights thorough history-taking as essential for guiding correct diagnosis and reinforces that infection with Capnocytophaga canimorsus should be investigated when there is a history of dog bite. [ABSTRACT FROM AUTHOR]

Reliable and recent data of human rabies deaths and animal bites are not available in India, where a third of global cases occur. Since there is a global target of eliminating dog-mediated human rabies by 2030, understanding whether the country is on track is essential. We aimed to estimate the animal-bite burden and the number of human rabies deaths in India. We conducted a community-based nationwide cross-sectional survey with a multistage cluster-sampling design from March 2, 2022 to Aug 26, 2023, covering 60 districts in 15 Indian states. The head of the household or an adult family member was interviewed to collect information about animal-bite history in family members, receipt of anti-rabies vaccination (ARV), and death following animal bite in the family. Annual animal-bite incidence along with 95% CIs were estimated after applying the sampling weights and adjusting for clustering. We estimated annual human rabies deaths using a decision-tree probability model with parameters from the community survey and laboratory data on rabies positivity among suspected rabid dogs. Of the 337 808 individuals residing in the 78 807 households surveyed, 2052 gave a history of animal bite, mostly (1576 [76·8%]) due to dogs in the past 1 year. The weighted and adjusted annual incidence of animal bite was 6·6 (95% CI 5·7–7·6) per 1000 population, translating into 9·1 million bites nationally. Annual dog-bite incidence was 5·6 (4·8–6·6) per 1000. Among people who had been bitten by a dog, 323 (20·5%) did not receive ARV, and 1043 (66·2%) received at least three doses. Nearly half (615 [49·1%]) of the 1253 individuals who received one dose did not complete their full course of vaccination. We estimated 5726 (95% uncertainty interval 3967–7350) human rabies deaths occurring annually in India. Although there was a substantial decline in human rabies deaths over the past two decades, to eliminate dog-mediated human rabies by 2030, India needs to fast-track its actions by adopting a focused one-health approach. Integrating human and animal surveillance, ensuring timely administration of full course of post-exposure prophylaxis, and accelerating dog vaccination across the country are crucial steps towards this goal. Indian Council of Medical Research. [ABSTRACT FROM AUTHOR]

Introduction and aim of study: Chronic wounds are increasingly challenging global healthcare. These wounds, which take over 3 months to heal, are complicated by untreated infections and the formation of biofilm, hindering healing and antibiotic effectiveness. To tackle these issues, new treatments like bacteriophage therapy are being explored. Bacteriophages, viruses that target bacteria, offer promise in overcoming antibiotic resistance. However, their use presents challenges that need to be addressed. Material and methods: Our review is based on the analysis of materials collected in Pubmed, Elsevier and other scientific articles using keywords: “chronic wound”, “chronic wounds infection”, “biofilms”, “MDR”, “bacteriophage”, “phage therapy”. Conclusions: The rise of chronic wounds due to resistant infections poses a significant challenge for patients and healthcare systems. Multidrug-resistant bacteria, often forming biofilm, evade current treatments, urging the search for alternatives. Phage therapy, showing efficacy against various stubborn infections, including those from surgery or diabetes, gains attention. Advanced delivery systems enhance targeted treatment, while phage cocktails improve effectiveness, especially against multiple resistant strains. Safety is generally observed, but larger trials are needed. Though not a replacement for antibiotics, phage therapy offers hope, needing robust clinical validation. While challenges exist, its societal, commercial, and economic benefits suggest a promising future beyond clinical use. [ABSTRACT FROM AUTHOR]

Large defects of the lip pose a reconstructive challenge due to the prominent facial location, significant impact on self-image and quality of life, and effects on functional needs such as oral competence, sensation, articulation, and maintenance of normal range of incisal opening. Current lip reconstruction practice follows guidelines based on defect depth and size. Optimal outcomes are achieved with use of local tissues which achieve better color, texture match, and ability to maintain sensation and orbicularis function. However, this is not usually possible in large defects. Cleft repair principles revolve around many of the similar goals of traumatic and oncologic lip reconstruction—to improve function and aesthetics. The authors present a case of a young male who sustained a traumatic lower lip avulsion defect involving greater than 75% of his lower lip. This was fully reconstructed using principles borrowed from cleft lip component repair, thus eliminating the need for a free flap without or without a tendon graft. This approach optimized aesthetic and functional outcomes, while avoiding several of the drawbacks of the classic oral flap reconstruction, especially in a young patient without static rhytids to camouflage reconstructive scars. In the presented technique, the senior author (OAA) successfully designed a modification of the classic Karapandzic repair technique utilizing principles from cleft lip reconstruction to address skin, muscle, and mucosa in separate components. This new modification of a classic technique presented by the authors utilizes principles from cleft lip reconstruction for improved functional and aesthetic outcomes in a single-stage reconstruction. This cross-pollination of principles resulted in the successful modification of traditional techniques leading to improved aesthetics, sensate reconstruction, complete oral competence, good maximal incisal opening and color match, and decreased scar burden. [ABSTRACT FROM AUTHOR]

Rabies remains a global health threat despite being preventable with post-exposure prophylaxis (PEP). This study assessed one-year humoral and T cell immunity in PEP recipients of the Insitut Pasteur du Cambodge (IPC) regimen, recommended by WHO. We analyzed rabies virus (RABV) neutralizing antibodies (nAbs) and T cell responses at baseline, 7 and 14 days, 6 and 12 months after PEP. A total of 148 patients were included, with 78 bitten by confirmed RABV-positive dogs receiving PEP and equine rabies immunoglobulins (eRIG), and 70 bitten by RABV-negative dogs receiving only PEP. Fourteen days after PEP, all but two individuals seroconverted for nAbs (≥ 0.5 IU/mL) with 87% maintaining this response even after 12 months. Interleukin-4 (IL-4) and interferon-gamma (IFN-γ)-secreting T cells were significantly elevated after 14 days and sustained for one year. No differences were observed between the RABV-exposed and -unexposed groups. This study demonstrates robust one-year immunity after IPC PEP. [ABSTRACT FROM AUTHOR]

An 11-year-old, 4.8 kg, intact male mixed-breed dog was evaluated for a bite wound that had occurred a day prior to consultation. On examination, the patient exhibited signs of early to-late decompensatory shock, hemothorax, pneumothorax, and rib fractures. Initial shock management and resuscitation were performed. After several days of stabilization, exploratory thoracotomy, thoracic wall reconstruction, culture sampling, and antibiotic susceptibility tests were conducted. Empirical antimicrobial treatments were performed while pending culture results. Despite aggressive antimicrobial therapy, the patient had focal seizures and wound dehiscence, presumably due to the worsening of infection and inflammation. Necrotic tissues adjacent to the dehiscence were debrided, and the wound was opened. A previous analysis of wound and blood cultures identified Candida glabrata , and itraconazole was initiated in accordance with the culture results. Successful treatment was achieved, and the wound was closed. The patient remained healthy after 2 months of monitoring. To the best of our knowledge, this was the first case report of systemic candidiasis in a dog secondary to a bite wound diagnosed via blood culture. Additionally, this case highlights successful treatment with itraconazole. [ABSTRACT FROM AUTHOR]

Rocky Mountain spotted fever (RMSF) is a severe tickborne disease that can reach epidemic proportions in communities with certain social and ecologic risk factors. In some areas, the case-fatality rate of brown dog tick-associated RMSF is up to 50%. Because of the spread of brown dog tick-associated RMSF in the southwestern United States and northern Mexico, the disease has the potential to emerge and become endemic in other communities that have large populations of free-roaming dogs, brown dog ticks, limited resources, and low provider awareness of the disease. By using a One Health approach, interdisciplinary teams can identify communities at risk and prevent severe or fatal RMSF in humans before cases occur. We have developed a conceptual framework for RMSF prevention to enable communities to identify their RMSF risk level and implement prevention and control strategies. [ABSTRACT FROM AUTHOR]

Dog bites are common within the United Kingdom, with their incidence increasing over recent years. Bites to the head and neck region can have substantial and multifactorial implications for victims, and can provide a challenge to maxillofacial departments. This study is a 10-year retrospective review of head and neck dog bites that required input from the maxillofacial team within the Cwm Taf Morgannwg University Health Board. Data collected included demographics of the patients involved, relationship with and breed of dog, nature of the injury, treatment received, and nature of any complications. In total, 168 records matched our inclusion criteria. The median age of our cohort was 12 years, with 57.1% of patients being younger than 15. Of the patients, 52.4% were female. Eighty-three per cent of cases involved a known dog, with Jack Russells being the breed most commonly involved. The upper lip was the most commonly affected area (30.3%), followed by the cheek (24.5%). Twenty-eight per cent of patients were admitted for management in theatre, with 8% of the total patients experiencing a complication. In conclusion, head and neck dog bites most commonly affect children and the upper lip. [ABSTRACT FROM AUTHOR]

Background: There is growing scientific interest in the benefits for children of interacting with and engaging with domestic dogs. Since the effects of such pairings on the dog are under explored, this study aimed to explore the lived experiences of family units supervising interactions between children in middle childhood (7–12) and the family dog(s)., Methods: Ten families with at least one child aged 7–12 years old (mean 8.6, SD 1.6) and a family dog were recruited via social media to participate in whole family unit face-to-face semi-structured interviews. Experience of the effects of child-dog interaction (CDI) on the family dog was explored through discussion and reflections of CDIs, the dog’s responses, and how these were managed. The interviews were recorded and transcribed verbatim, and thematic analysis using a semantic approach was used to construct key themes., Results: All families reported that the most positive CDIs were of mutual play or that the dog freely approached the child with the ability to move away. This dynamic is subsequently referred to as dog freedom of choice (FOC). Most discussed experiences of dog aggression or avoidance of the child when FOC was compromised by close physical contact (CPC) from the child, such as cuddling. In most cases, the caregivers and children within the family unit were aware that the dog did not always enjoy such a CPC. However, interviewees recognised that such awareness did not always lead to cessation of the interaction., Conclusions: While shared play where FOC was supported suggested mutual benefits, CDIs perceived as expressions of affection, for example, hugs towards the family dog, may compromise dog quality of life and raise the risk of dog bites. Furthermore, a caregiver or child with conscious awareness of a dog reacting aversely to compromised FOC is not always a mechanism for ending of the interaction. This may raise questions about the efficacy of education programmes intended to raise the recognition of dog body language to change human behaviour.

Abstract Background/objective Shortly after the onset of the COVID Pandemic, when many schools and outside activities were suspended, dog adoption rates increased. It is unknown if increased dog adoption rates along with stay-at-home orders resulted in changes to pediatric dog bite injuries. The objective of this study was to examine the incidence and characteristics of dog bites in children seen in a pediatric emergency department (PED) during the pandemic compared to before. Methods A retrospective review of children evaluated in the PED of a level 1 pediatric trauma center and its satellite PED from March 2018 through February 2022 who had a discharge diagnosis of dog bite (ICD-10 W54.0XXA) was conducted. Pre-pandemic cases, March 2018 through February 2020, were compared to those that occurred during the pandemic, March 2020 through February 2022. Results There were 2,222 patients included in the study. Compared to pre-pandemic cases, the incidence for the first 12 months of the pandemic was 1.5 times higher than the pre-pandemic 12-month periods but returned closer to the pre-pandemic rates during the second 12 months of the pandemic. More patients were admitted during the pandemic (6.1% vs. 3.7%, p

Background: Rabies remains a major public health problem in low- and middle-income countries. However, human rabies deaths are rarely laboratory-confirmed or sequenced, especially in Africa. Five human rabies deaths from Tanzania and Kenya were investigated and the causative rabies viruses sequenced, with the aim of identifying implications for rabies control at individual, healthcare and societal levels. Case presentation: The epidemiological context and care of these cases was contrasting. Four had a clear history of being bitten by dogs, while one had an unclear biting history. Two individuals sought medical attention within a day of being bitten, whereas three sought care only after developing rabies symptoms. Despite seeking medical care, none of the cases received complete post-exposure prophylaxis: one patient received only tetanus vaccination, one did not complete the post-exposure vaccination regimen, one followed an off-label vaccination schedule, and two did not receive any post-exposure vaccinations before the onset of symptoms. These cases highlight serious gaps in health-seeking behaviour, and in health systems providing appropriate care following risky exposures, including in the accessibility and effectiveness of post-exposure prophylaxis as it is administered in the region. Conclusions: The viral genomic and epidemiological data confirms dog-mediated rabies as the cause of each of these deaths. The phylogenetic investigation highlights the transboundary circulation of rabies within domestic dog populations, revealing distinct rabies virus clades with evidence of regional spread. These findings underscore the importance of coordinated cross-border control efforts between the two countries. Urgent action is needed to improve awareness around the need for emergency post-exposure vaccines that should be accessible in local communities and administered appropriately, as well as investment in coordinated dog vaccination to control dog-mediated rabies, the underlying cause of these deaths. [ABSTRACT FROM AUTHOR]

Background: Rabies is a disease of warm-blooded animals that affects the central nervous system and is almost invariably fatal once clinical signs develop. It is one of the most neglected tropical diseases in several areas of the world, including Ethiopia. Additionally, the burden of the disease is estimated to be high in Ethiopia, and public awareness contributes to prevention. Methods: A community-based cross-sectional study design was conducted from June–August 2023 in the Gomma district, Jimma zone, Oromia regional state, Ethiopia, to assess the knowledge, attitudes, and practices of communities towards rabies and associated risk factors using a structured questionnaire survey. A multi-stage sampling technique was used for the selection of the sampling units and a total of 140 participants were interviewed. The questionnaire parts included socio-demographics information, knowledge, attitudes, and practices of the community's respect for rabies management and control. The data was analyzed by Statistical Package for Social Science (SPSS) Version 20. Descriptive analyses were employed and multivariable logistic regression was used to calculate the association between independent and dependent variables (Knowledge, Attitudes, and Practice scores). Results: About 134 (95.7%) respondents had heard about rabies. Likewise, 75 (53.6%), 55 (39.3%), and 95 (67.9%) of the respondents had good knowledge, favorable attitudes, and good practices, respectively. Christians were more likely to have higher knowledge scores than Muslims (AOR = 6.876, CI = 1.750–27.016, p = 0.006). Respondents who knew someone's exposure had a higher knowledge score than those who did not (AOR = 6.208, CI = 2.750–14.012, p = 0.000). Moreover, Muslims were found to have a more favorable attitudes than Christians (AOR = 5.518, CI = 1.199–25.391, p = 0.028). Those who knew someone's exposure to rabies were found to have a more favorable attitudes than those who did not (AOR = 2.367, CI = 1.157–4.839, p = 0.018). Respondents who had favorable attitudes towards rabies were found to have more good practices than unfavorable attitudes (AOR = 3.267, CI = 1.391, 7.730, p = 0.005). Conclusions: The study revealed a gap in knowledge among communities in the study area. Thus, rabies control activity and community awareness should be implemented with stakeholders. Author summary: In a comprehensive assessment conducted in the Gomma district of Jimma zone, Ethiopia, the community's knowledge, attitudes, and practices related to rabies were assessed. While participants generally acknowledged domestic dogs and wild carnivores as the primary source of rabies and were able to identify various preventive measures such as avoiding dog bites and ensuring dog confinement, significant disparities were evident. Despite possessing a reasonable level of knowledge, attitudes, and practices were found to be inconsistent with effective rabies prevention. Notably, a prevalent belief persisted among participants that rabies could be cured through traditional herbal medicine, indicating a misconception regarding the disease's treatment. Additionally, a troubling trend emerged where animals involved in bite incidents were often killed instead of being quarantined, contrary to established guidelines. Recognizing the urgent need for intervention, the study emphasizes the critical role of enhancing awareness and promoting culturally and gender-sensitive educational programs. These initiatives should aim to rectify misconceptions, improve first aid practices, and foster appropriate healthcare-seeking behaviors among community members and healthcare providers alike. By implementing these multifaceted strategies, communities can work towards achieving a significant reduction in the burden of rabies and safeguarding public health. [ABSTRACT FROM AUTHOR]

Background/objective: Shortly after the onset of the COVID Pandemic, when many schools and outside activities were suspended, dog adoption rates increased. It is unknown if increased dog adoption rates along with stay-at-home orders resulted in changes to pediatric dog bite injuries. The objective of this study was to examine the incidence and characteristics of dog bites in children seen in a pediatric emergency department (PED) during the pandemic compared to before. Methods: A retrospective review of children evaluated in the PED of a level 1 pediatric trauma center and its satellite PED from March 2018 through February 2022 who had a discharge diagnosis of dog bite (ICD-10 W54.0XXA) was conducted. Pre-pandemic cases, March 2018 through February 2020, were compared to those that occurred during the pandemic, March 2020 through February 2022. Results: There were 2,222 patients included in the study. Compared to pre-pandemic cases, the incidence for the first 12 months of the pandemic was 1.5 times higher than the pre-pandemic 12-month periods but returned closer to the pre-pandemic rates during the second 12 months of the pandemic. More patients were admitted during the pandemic (6.1% vs. 3.7%, p < 0.05). Facial and multiple injuries occurred more frequently during the pandemic (face 35.9% vs. 33.5%: multiple 18.5% vs. 15.6% p < 0.05). Conclusions: There was a higher incidence of PED visits, higher admission rates, and an increase in multiple body part and facial injuries in children with dog bite injuries during the COVID pandemic compared to pre-pandemic. Pediatric providers should emphasize safe dog interactions with anticipatory guidance. [ABSTRACT FROM AUTHOR]

In Serbia, Babesia gibsoni in dogs is less common than Babesia canis. Although two clinical cases were reported a decade ago, no additional clinical reports have since been published. Recently, a co-infection of B. gibsoni and B. canis was documented in Austria following a dog's trip to Serbia. The objectives of this study were to present comprehensive clinicopathological results of two clinical cases of B. gibsoni monoinfection in dogs in Serbia. Two male dogs: an 11-year-old Shih Tzu, and a 2-yearold Pit Bull Terrier, presented with clinical signs related to babesiosis with a history of biting by another dog. Both dogs had regenerative anemia, thrombocytopenia, and monocytosis while Shih Tzu had immune-mediated hemolytic anemia (IMHA). B. gibsoni mono-infection was confirmed by PCR testing. Both dogs were treated with a single dose of imidocarb-dipropionate, and a combination of metronidazole, clindamycin, and doxycycline (MCD protocol). The Shih Tzu also received prednisolone for three weeks. Following the MCD protocol, the Pitt Bull recovered, although thrombocytopenia persisted for nine months. In contrast, Shih Tzu's clinical condition worsened. The prednisolone treatment was discontinued, and azithromycin and atovaquone were introduced, leading to recovery after another three weeks of treatment. Long-term clinical and PCR monitoring revealed that the Pit Bull Terrier exhibited a more favorable response and a lower frequency of relapses compared to Shih Tzu. The findings suggest that B. gibsoni has become a clinically significant pathogen in Serbia. The MCD protocol appears effective for treating acute B. gibsoni infection in dogs, but further investigation is required to evaluate its efficacy in eliminating the parasite. [ABSTRACT FROM AUTHOR]

Background The veterinary workplace carries a high risk of staff accidents and injuries, yet there is scant research exploring it in comparison with other comparable fields, such as human medicine. Aims To understand how veterinary professionals define injuries and to understand what injuries they do, or do not, deem reportable. Methods A cross-sectional survey comprising demographic questions and open-text questions was shared with veterinary practice staff across the UK. Data were analysed descriptively and using an inductive content analysis. Results There were 740 respondents, who were broadly representative of the veterinary profession. There were differences in how injuries were defined; for example, small animal veterinarians expected injuries to involve blood, while equine and production animal veterinarians were more likely to expect injuries to reduce their ability to perform work and require medical treatment. Many suggested that 'all' workplace injuries should be reported; however, 'minor' injuries were often overlooked, for example, needlestick injuries did not always meet the criteria of being an 'injury'. Injuries caused by staff themselves (e.g. trips) were less likely to be reported than injuries that could be blamed on an external factor (e.g. dog bite). Conclusions Collectively, the data suggest a wide-ranging perception of risk of injury in practice, with some harms seen as 'everyday norms'. Veterinary practices should interpret their injury statistics with a high degree of caution. They should explore the microcultures within their practices relating to worker perception of risk, injury and barriers to reporting. [ABSTRACT FROM AUTHOR]

Background: In India, over 35% of global human Rabies deaths occur, primarily from dog bites which are responsible for over 95% of cases. Objective of this study was to assess the epidemiological profile and practices regarding animal bite, among animal bite victims attending the OPD of Rural Health and Training Centre affiliated to a Tertiary Care Centre in Rewa. Methods: This was a facility based cross-sectional study. Sample size was 150. New animal bite victims were interviewed using a semi-structured questionnaire after obtaining informed verbal consent. The questionnaire consisted of demographic profile and questions regarding victims’ awareness about rabies, anti-rabies vaccine and their practices following the animal bite. Conclusion: Younger age group (persons of 0-30 years age group) are more commonly affected. Awareness among participants may be raised by utilising school health programs Major biting animals were dogs. Very few people are aware of the need for observing animals post bite. Wound care practices need to be improved. Pet dog rabies vaccination rate is very low, which needs to be focused upon for achieving rabies control. [ABSTRACT FROM AUTHOR]

Background/Objectives: Although rare in the Western world, dog bites may be lethal or lead to physically severe outcomes. However, little attention is given to their psychological consequences. We aimed to review their psychological consequences in children 1–14 years of age, focusing on the prevalence and nature of psychological disorders, evaluating the impact on future mental health of children and their families, and assessing the effectiveness of preventive interventions and measures. Methods: On 23 May 2024, we investigated the PubMed, CINAHL, and PsycINFO/PsycARTICLES databases using ("dog bite" OR animal-induced OR animal-caused) AND (psychol* OR mental OR psychiatr* OR anxiety OR anxious OR depress* OR obsess* OR trauma* OR psychosis OR psychotic OR schizophren* OR schizoaffect*) filtered for ages 0–18 years. This resulted in 311 records, of which 50 were eligible. These included original research, case reports, patient surveys, and reviews/meta-analyses. Results: Findings indicate that younger children are particularly vulnerable, often suffering head/neck bites, leading to severe injuries and psychological distress, with post-traumatic stress disorder (PTSD) being a common outcome. Symptoms such as nightmares, flashbacks, anxiety, and social withdrawal were frequently reported. Positive parental support and timely psychological interventions were found to mitigate these effects. Conclusions: Interdisciplinary approaches integrating education, cognitive restructuring, and behaviour modification are needed to effectively prevent and address the psychological impacts of dog bites. Summarising, dog bites in children result in substantial psychological sequelae, necessitating robust prevention and intervention strategies to improve their quality of life and reduce the risk of chronic mental conditions. [ABSTRACT FROM AUTHOR]

The authors present the case of a 61-year-old man found dead in an agricultural plot. The first investigation of the scene revealed the corpse laid face up in a spot of partially dried blood, next to an olive tree. His face, arms, legs, and abdomen showed signs of severe contusion and laceration of dogs' bite wounds. Next to the victim, an olives bin had been found overturned on the ground. A multi-disciplinary approach, including crime scene analysis, autopsy findings, veterinary animals review, odontologist bite mark study, and forensic genetics DNA correlations, was performed. The present case is a documented watchdogs lethal pack attack and provides an example of how to recognize the more active participants thanks to their odontological alterations. It could be considered the first described dog pack attack case solved by dysgnathia alteration. Comparisons between the dental casts obtained from the dogs and the inflicted wounds were made, resulting in positive correlations between the injuries and the dental arches from two of the six involved dogs, thanks to dental abnormalities and DNA founding. The victim's clothes were also compared with the dogs' dental casts, confirming that they were the most active participants during the pack attack. Dogs' DNA was finally matched with saliva traces found on victim's clothes and skin bite marks. [ABSTRACT FROM AUTHOR]

Rabies is a severe viral infection known for its rapid onset and high mortality rate. The virus is primarily transmitted to humans through bites or saliva from animals such as dogs, and once symptoms appear, it often results in death. Although advancements in vaccination and health education have mitigated the global impact of rabies to some extent, it remains a significant public health challenge. The human immune system can be compared to a country with layered defenses and a central command system, while the rabies virus acts as a cunning and well-equipped spy. Suppose an adult male is bitten by a rabid dog, allowing the rabies virus to infiltrate. We will observe how the immune system engages in a battle of wits with the virus. [ABSTRACT FROM AUTHOR]

Naturally occurring diabetes mellitus (NODM) is one of the most common endocrine disorders in dogs and its etiology closely resembles type 1 diabetes mellitus (T1DM) in people. Human patients with T1DM commonly have cellular derangements consistent with inflammation, impaired immune function, and hypovitaminosis D. There is little information available regarding inflammatory biomarkers, immune function, and vitamin D status in diabetic dogs. Therefore, our objectives were to assess inflammatory biomarkers, vitamin D metabolites, and phagocytic capacity in diabetic dogs and determine whether associations exist with these variables and the level of clinical control or vitamin D metabolites. This was a prospective case--control study that included 20 otherwise healthy diabetic dogs (clinically controlled, n = 10; uncontrolled, n = 10) and 20 nondiabetic, healthy, age (± 2 years), breed, and sex matched controls. Complete blood count, biochemical panel, urinalysis, and fructosamine were performed at a single commercial reference laboratory. Basal plasma tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-8, and IL-10 were measured using a canine-specific multiplex bead-based assay. Serum C-reactive protein (CRP) was measured using a commercially available ELISA kit. Serum 25-hydroxyvitamin (OH)D3 and 24,25-dihydroxyvitamin (OH)2D3 were measured with HPLC. Phagocytosis of opsonized-Escherichia coli (E. coli) was evaluated with flow cytometry. Diabetic dogs had higher serum CRP concentrations than controls (p = 0.02). Plasma IL-8 concentrations were higher in diabetic dogs with uncontrolled clinical disease compared to controls (p = 0.02). Diabetic dogs had a lower percentage of leukocytes that phagocytized opsonized-E. coli (p = 0.02), but an increased number of bacteria phagocytized per cell (p < 0.001) compared to controls. No between-group differences were identified in vitamin D metabolites, nor were associations found between vitamin D and any variables. Fructosamine had a positive association with serum CRP concentration (rho = 0.35, p = 0.03) and number of bacteria phagocytized per cell (rho = 0.45, p = 0.004) in our cohort (n = 40). Like people with T1DM, diabetic dogs have a proinflammatory phenotype and phagocytic dysregulation that may be correlated with glycemic control. [ABSTRACT FROM AUTHOR]

Introduction: Left atrial volume (LAV) obtained using real-time three-dimensional echocardiography (RT3DE) is an independent predictor of postcapillary pulmonary hypertension (PH) in humans; however, no studies have investigated LAV obtained using RT3DE as a predictor of post-capillary PH in dogs with myxomatous mitral valve disease (MMVD). Therefore, we aimed to evaluate the clinical applicability of LAV obtained using RT3DE compared to that obtained using two-dimensional echocardiography (2DE) in dogs with MMVD, with or without PH. Methods: Medical records and echocardiographic images of 237 privately owned dogs with naturally occurring MMVD with or without PH were retrospectively reviewed. A total of 49 privately owned dogs with naturally occurring MMVD, with or without PH, were finally included (35 MMVD without PH, 14 MMVD with PH). The LAV and left ventricular volumes were obtained using 2DE and RT3DE. Echocardiographic parameters were analyzed to identify independent predictors of post-capillary PH. Results: We found that the left atrial and left ventricular volumes obtained using 2DE and RT3DE indexed to body weight and several 2DE-derived variables were univariately associated with post-capillary PH. Furthermore, multivariable logistic regression analysis revealed that the RT3DE minimum LAV indexed to body weight (LAVi min) was the only significant independent predictor of post-capillary PH (odds ratio, 12.86; 95% confidence interval [CI], 2.40--68.99; p = 0.003), with the highest area under the curve value of 0.86 (95% CI, 0.75-0.96; p < 0.001). Discussion: In conclusion, LAV indexed to body weight obtained using 2DE and RT3DE, can be a useful predictor of post-capillary PH in dogs with MMVD. In particular, the RT3DE LAVi min was observed to be the strongest predictor of post-capillary PH. [ABSTRACT FROM AUTHOR]

Rabies virus (RABV) is the causative agent of rabies, a lethal neurological disease in mammals. RABV strains can be classified into fixed strains (laboratory strains) and street strains (field/clinical strains), which have different properties including cell tropism and neuroinvasiveness. RABV Toyohashi strain is a street strain isolated in Japan from an imported case which had been bitten by rabid dog in the Philippines. In order to facilitate molecular studies of RABV, we established a reverse genetics (RG) system for the study of the Toyohashi strain. The recombinant virus was obtained from a cDNA clone of Toyohashi strain and exhibited similar growth efficiency as the original virus in cultured cell lines. Both the original and recombinant strains showed similar pathogenicity with high neuroinvasiveness in mice, and the infected mice developed a long and inconsistent incubation period, which is characteristic of street strains. We also generated a recombinant Toyohashi strain expressing viral phosphoprotein (P protein) fused with the fluorescent protein mCherry, and tracked the intracellular dynamics of the viral P protein using live-cell imaging. The presented reverse genetics system for Toyohashi strain will be a useful tool to explore the fundamental molecular mechanisms of the replication of RABV street strains. [ABSTRACT FROM AUTHOR]

Despite continuous efforts of veterinary services to control rabies in dogs since 1982, rabies remains a cause of death in Tunisia, with more than five reported human cases in 2022. As little is known on the determinants of transmission of rabies in dogs, better understand which factors contribute to its spatial heterogeneity in Tunisia is critical for developing bespoke mitigation activities. In this context, we developed Bayesian Poisson mixed-effect spatio-temporal model upon all cases of rabid dogs reported in each delegation during the period from 2019 to 2021. The best fitting model highlighted the association between the risk of rabies and the mean average monthly temperature, the density of markets and the density of dogs in delegations. Interestingly, no relationship was found between intensity of vaccination in dogs and the risk of rabies. Our results provided insights into the spatio-temporal dynamics of dog rabies transmission and highlighted specific geographic locations where the risk of infection was high despite correction for associated explanatory variables. Such an improved understanding represent key information to design bespoke, cost-efficient, rabies prevention and control strategies to support veterinary services activities and policymaking. Author summary: Rabies, a deadly zoonotic disease, remains a public health concern in Tunisia despite ongoing prevention efforts. Our study, the first of its kind in Tunisia, aimed to analyze the spatiotemporal distribution of dog rabies and identify factors influencing its spread. Using a Bayesian approach, we examined the relationships between epidemiological, socio-economic, and environmental factors and the occurrence of rabies cases in different regions (delegations) of Tunisia. Our study revealed that variations in the risk of rabies were primarily associated with spatial effects rather than temporal trends. We found a negative association between average monthly temperature and dog rabies cases, consistent with decreased viral survival and dog activity in warmer temperatures. The risk of rabies cases had a non-linear relationship with dog density. We also found that dog rabies risk was positively associated with the density of slaughterhouses, indicating that these locations might contribute to interactions between infected and susceptible animals. Surprisingly, vaccination coverage did not show a significant association with rabies risk. Our findings contribute to the global goal of eradicating rabies by 2030 and underscore the importance of adapting strategies based on the unique factors influencing disease transmission in specific regions. [ABSTRACT FROM AUTHOR]

To describe the incidence and victim demographics of Welsh hospital admissions due to dog bites and strikes from 2014 to 2022. Descriptive analysis of Welsh hospital admissions data. Residents of Wales admitted to a Welsh National Health Service (NHS) hospital for a dog bite or strike, were identified using ICD-10 codes. The annual incidence of dog bite and strike admissions between 2014 and 2022 was calculated and stratified by child–adult status, sex, and Local Health Boards. Trends over time were analysed using the Chi-square test for trends. Hospital admissions due to dog bites and strikes have significantly increased from 16.3 per 100,000 to 23.7 per 100,000 population in 2022. This was driven by an increase in non-geriatric adults and an increase in three Local Health Boards. The Swansea Bay area has the highest incidence in Wales (56.1 admissions per 100,000). Wales has a higher incidence of dog bites and strikes than England or the Republic of Ireland. Work in the communities where incidence is exceptionally high is needed to understand the reasons behind having the highest incidence of dog bites in the British Isles and to establish the most efficacious methods for bite prevention. [ABSTRACT FROM AUTHOR]

Background and Aim: Canine rabies is an endemic form of zoonosis and represents a major public health threat in Guinea, similar to other African countries. However, few investigations on the epidemiology of rabies in animals and humans have been conducted, and evidence-based data required to inform health policies remain inadequate. This study was conducted to update our knowledge of human dog-mediated rabies epidemiology and post-exposure prophylaxis (PEP) accessibilityrelated factors in Guinea. Materials and Methods: This retrospective study, conducted from January 2018 to December 2020, collected data on animal bite cases, veterinary observations, rabies diagnoses through fluorescent antibody test, and PEP delivery from three veterinary and medical entities. Statistical analysis utilized Chi-square test and Fisher's exact test to evaluate relationships between variables. Results: An average of 775 bites was recorded annually, and dogs were responsible for 98% of bites. However, only 64% of the biting dogs were under veterinary observation as required for integrated bite case management. Regarding the geographical distribution of bite cases, the entire country was affected, with the highest number of bites recorded in the prefectures of Nzérékoré and the special zone of Conakry. In addition, the laboratory diagnosis of brain samples from biting dogs indicated that 72% of the samples were rabies-positive. However, regarding prevention, only 58% of the bitten individuals received full PEP. Conclusion: Improving disease surveillance and PEP provision for dog-transmitted rabies is crucial to preventing human cases and deaths. Increasing community awareness is essential for enhancing dog vaccination and PEP utilization. A national action plan integrating stakeholders for controlling canine rabies should be developed for effective One Health collaboration. [ABSTRACT FROM AUTHOR]

ABSTRACT: Context: Rabies is a fatal zoonotic disease that is endemic in India. Both forms of rabies, namely, encephalitic and furious, invariably lead to coma and death. Lack of awareness is the most critical barrier in accessing timely post-exposure prophylaxis that can prevent the progression to clinical disease. Aims: To report the case series of fourteen clinically suspected rabies cases. Settings and Design: We followed a retrospective study design. Data were collected from the Anti Rabies Section of Government Medical College, Jammu, which is a tertiary care hospital of Jammu Division. Methods and Material: We collected data of all patients over a period of three years, from 2017 to 2020, who were diagnosed as cases of clinically suspected rabies on the basis of classic signs and symptoms and who finally succumbed to the disease. Statistical Analysis Used: Descriptive statistics was used to describe the results of the study Results: In the present description, the mean age of the patients was 31 ± 18.6 years. Out of 14 suspected cases, 9 had not received any post-exposure prophylaxis—neither vaccine nor serum—and instead visited spiritual faith healers. The remaining patients had history of either incomplete, unknown, or incorrect vaccination status. Median duration of presentation of symptoms after dog bite was 42 days, with a range of 15–180 days. Mean survival of patients after presentation of symptoms was around 1.8 days Conclusions: Low level of awareness resulted in non-seeking of health-care services after animal bites. [ABSTRACT FROM AUTHOR]

Children are frequently injured by animal bites, and dog bites account for a large portion of the rabies epidemic worldwide. This case report describes a 3-year-old girl who was bitten by a stray dog and ended up in the emergency room with multiple injuries. The child had extensive bite injuries all over her body. For such injuries, suturing the lesions is the preferred course of action, in conjunction with antibiotic therapy and rabies vaccination. It is essential to administer complete wound care and immediate post-exposure prophylaxis against rabies to guarantee successful treatment and favorable patient results. This report details the child's case, who was followed for 3 months and showed good wound healing and recovery. [ABSTRACT FROM AUTHOR]

Introduction: Capnocytophaga ochracea is found in the human oral microbiome and is a rare cause of antibiotic-resistant, opportunistic septicemia in immunocompromised hosts. The zoonotic transmission of C ochracea from canines to humans has not yet been reported in the literature. Cohabitation with people is associated with oral colonization in dogs and may be a reservoir for Capnocytophaga infections, which have a decreased susceptibility to first-line antibiotics commonly used to treat animal exposures. Case Report: This is the case of a 70-year-old male with a remote history of lymphoma status post splenectomy, in remission, who presented with stigmata of Capnocytophaga septicemia after a dog bite, which included purpura fulminans on physical examination. Initial broad-spectrum coverage with cefepime failed to slow the progression into multiorgan failure. A Capnocytophaga strain with extended resistance was suspected. Antibiotics were transitioned to meropenem, and the patient eventually made a good recovery. Blood cultures isolated C ochracea. Conclusion: Capnocytophaga infections should be suspected in patients with severe sepsis and purpura fulminans after a canine exposure. Canine pets may be a reservoir for Capnocytophaga species with increased antibiotic resistances, such as C ochracea, which trace their origins to the human oral microbiome. A thorough medical history is essential to identify risk factors such as asplenia and active immune compromise that are associated with infections from antibiotic-resistant strains and worse outcomes. For Capnocytophaga infections that fail initial therapies, cephalosporins should be avoided because of high resistance rates, and the use of carbapenems may be favored over combination beta-lactam/beta-lactamase inhibitors in select clinical scenarios. [ABSTRACT FROM AUTHOR]

ABSTRACT Dog bites are a source of zoonotic infections to humans, such as pasteurellosis and meningitis. Zoonotic bacterial identification and their antibiotic susceptibility assessment are key towards the successful management of such infections. This study isolated and identified zoonotic bacterial species from the oral cavities of indigenous dogs and also determined their antibiotic susceptibility profile. Oral swab samples collected from 54 indigenous dogs (domestic [36] and stray [18]) were cultured on agar media, and then on selective‐differential media. The colony morphology and conventional biochemical tests were used to identify the bacterial isolates. Antibiotic susceptibility was evaluated using the Kirby–Bauer disk diffusion method. A total of 232 bacterial isolates were obtained, from which 29 bacteria species (18 Gram‐negative and 11 Gram‐positive) belonging to 19 genera and 13 families were identified. Aerobic and anaerobic bacteria species constituted 69% and 31%, respectively. The most prevalent bacteria species was Staphylococcus aureus (10.8%) followed by Escherichia coli (9.5%), while Yersinia enterocolitica (0.4%) was the least common. Most bacteria species belonged to family Enterobacteriaceae (11) followed by Vibrionaceae (04). All the sampled dogs had a number of multi‐drug–resistant superbugs in their oral cavities. However, all the tested bacterial isolates were only susceptible to imipenem and chloramphenicol. All the identified bacteria species were resistant to metronidazole, amoxicillin‐clavulanic acid and ceftazidime. Therefore, antibiotics such as imipenem and chloramphenicol could be of better choice for managing dog bite infections compared to the antibiotics recommended by Uganda Clinical Guidelines, such as metronidazole and amoxicillin‐clavulanic acid.

Odontodysplasia is an uncommon dental developmental disorder associated with enamel, dentin, pulp abnormalities, and overall tooth morphology. The affected tooth is grossly abnormal in size and contour and is commonly associated with swelling of the affected area and failure of eruption. Histologically, the enamel and dentin are hypoplastic and hypomineralized. Odontodyplasia occurs most commonly in response to direct trauma to the developing tooth bud (enamel organ and dental follicle). Data on the prevalence and features of non-traumatic odontodysplasia are lacking. Medical records of dogs diagnosed with odontodysplasia were reviewed at the William R. Pritchard Veterinary Medical Teaching Hospital (VMTH), University of California, Davis, for 10 years (from 2013 to 2023). Dogs with a known history of facial trauma, persistent deciduous tooth or teeth over the region of odontodysplastic tooth or teeth, and endodontic disease of the persistent deciduous tooth or teeth were excluded from the study. Twenty-eight dogs were included in this retrospective study, representing an incidence of 1.4 per 100 dogs presenting over 10 years. Regional odontodysplasia (RO) was identified in twenty-two dogs, and generalized odontodysplasia (GO) was found in six dogs. Both comprehensive oral examination and diagnostic imaging were essential in diagnosing and assessing the presence of odontodysplasia. Awake oral examination failed to identify odontodysplasia in almost 70% of the RO cases. Secondary diseases or lesions in odontodysplastic teeth, such as periodontal disease, endodontal disease, and perio-endo lesions, were commonly seen and were particularly more frequently identified in strategic teeth (canine and carnassial teeth) than non-strategic ones. Similarities, such as female predilection, maxilla more commonly affected, and clinical signs, were observed between RO in dogs and those reported in people. The exact etiology of non-traumatic odontodysplasia remains elusive, and the condition may be of multifactorial causality. [ABSTRACT FROM AUTHOR]

Echinococcus multilocularis is a cestode that causes human alveolar echinococcosis, a lethal zoonotic disease distributed in the northern hemisphere. The life cycle of this parasite is maintained in nature by voles as intermediate hosts and foxes as definitive hosts in Hokkaido, Japan. Although dogs are also susceptible to the parasite, the infection has been considered typically asymptomatic. We report the detection of E. multilocularis eggs in the diarrheal feces of a dog with chronic gastrointestinal signs, which disappeared after anthelmintic treatment. The mitochondrial genome sequence constructed by sequencing of the overlapping PCRs using DNA from the eggs was identical to the most predominant haplotype previously reported in red foxes in Hokkaido. This case highlights that Echinococcus infection should be considered as a differential diagnosis for diarrheal dogs in the disease endemic areas. Further efforts are needed to accumulate parasite genotypes in domestic dogs as well as humans to assess the risk of human infection from dogs. [ABSTRACT FROM AUTHOR]

Maternal behavior research in laboratory rats has revealed important behavioral and neurobiological mechanisms governing the onset, maintenance and decline of maternal behavior. However, the extent to which these mechanisms are evolutionarily conserved across species is less clear. This manuscript proposes that examining these mechanisms in dogs may be a viable approach to test their generality and help bridge the gap between rodent and human research, as domestic dogs show greater individual differences and exhibit more human-like maternal characteristics than rodents. These aspects represent advantages over rodent models, which in turn allow systems biological approaches not available in rodents. Additionally, domestic dogs share similar social environments with humans, suffer from the same mental disorders as humans, and can be treated with the same medications. This paper begins with a summary of key findings and theoretical developments from decades of rat maternal behavior research, followed by a literature review of the extant maternal behavior research on dogs and related methodology, highlighting the unique behavioral characteristics of dog maternal behavior and similarities and differences from rat maternal behavior. Finally, several knowledge gaps in dog maternal behavior research, as well as the future research in this area is discussed. It concludes that research on dog maternal behavior will not only advance our understanding of the universality of the neurobiological and behavioral mechanisms in maternal behavior, but also improve our understanding of risk factors associated with postpartum mental disorders. [ABSTRACT FROM AUTHOR]

Background: Rabies is an acute and fatal zoonotic viral disease that affects warm-blooded mammals. This disease is usually transmitted between humans and other animals through bites, scratches, or saliva from infected animals. Depending on the mortality rate of rabies, people sometimes experience mental stress after biting or contact. This condition is called mental stress toward rabies (Rabies Hysteria). Cases Report: In this study, we referred to seven cases of rabies hysteria, which were referred to the WHO Collaborating Center for Reference and Research on Rabies of Pasteur Institute of Iran. Conclusion: Studies have shown that the level of low awareness and the wrong attitude toward the disease aggravates medical hysteria. The health system should evaluate social knowledge and attitude. [ABSTRACT FROM AUTHOR]

Capnocytophaga canimorsus and Capnocytophaga cynodegmi are commensal bacteria in the oral cavities of dogs. Both are zoonotic pathogens that could infect humans via dog bites. C. canimorsus may cause life-threatening infections in humans, whereas C. cynodegmi infections tend to be milder and more localized. Capsular serovars A–C of C. canimorsus seem to be virulence-associated. Some of the C. canimorsus serovars described to date can also be detected in other Capnocytophaga species, including C. cynodegmi. The objective of this pilot study was to investigate the emergence of C. canimorsus and C. cynodegmi after birth in oral cavities of puppies and to evaluate the impact of the dam's Capnocytophaga spp. carrier status on the emergence. Ten litters, altogether 59 puppies, were included in the study. The puppies and their dams were sampled at five time points over seven weeks after whelping. Oral swab samples taken were investigated for the presence of C. canimorsus and C. cynodegmi by species-specific polymerase chain reaction (PCR), the specificity of which was verified by sequencing a selection of the PCR products. Samples that were positive in Capnocytophaga PCR reactions were also capsular-typed by PCR to gain more knowledge about the Capnocytophaga spp. present in the samples. Altogether 10.2% and 11.9% of puppies, or 20.0% and 30.0% of litters tested PCR-positive for C. canimorsus and C. cynodegmi, respectively. Capnocytophaga PCR-positive puppy samples were always positive for only C. cynodegmi or C. canimorsus, not both. Most Capnocytophaga PCR-positive puppies became positive at the age of 5 to 7 weeks. Only a minority (5/16) of the C. cynodegmi PCR-positive dog samples were positive in capsular typing PCR, whereas all C. canimorsus PCR-positive dog samples were negative in capsular typing PCR. For all Capnocytophaga PCR-positive puppies, their dam was positive for the same Capnocytophaga species. These results suggest that puppies become colonized by C. cynodegmi or C. canimorsus from their dams at the time of deciduous teeth eruption. [ABSTRACT FROM AUTHOR]

Individuals, including researchers, often have to form beliefs about the political world from nonrepresentative samples—e.g., their friends, what they see on TV, or content on social media. Substantial evidence indicates that many struggle to account for this selection problem and generally form beliefs as if what they observe is representative. In this review, we provide a formal typology of how this phenomenon of selection neglect affects political beliefs. We identify three types of selection neglect: homophily leads individuals to believe others' traits and beliefs are closer to their own; the squeaky wheel effect biases beliefs toward more visible or vocal groups; and the man bites dog effect leads to excessive belief in extreme or unusual events. Selection neglect is a unifying way to understand disparate literatures on perceptions of the economy and demographics, beliefs about others' beliefs, partisan media, and social media. Much empirical research is consistent with biased beliefs driven by selection neglect but rarely directly tests this mechanism outside of lab settings. We discuss how future research can provide more direct evidence. [ABSTRACT FROM AUTHOR]

This retrospective study examined dog bite cases reported at the Federal Medical Centre in Jalingo, Taraba State, Nigeria from 2011 to 2021. Over the 11-year period, 553 dog bite cases were reported, constituting 0.81% of the total consultations at the hospital. The study found that the prevalence of dog bites was highest in individuals over 21 years of age (40.5%), followed by those aged 11-20 years (30.2%) and 0-10 years (29.3%). Males reported a significantly higher number of dog bites (63.7%) compared to females (36.3%). Most of the bite injuries occurred on the lower limbs (83.5%). Seasonally, the highest number of dog bite cases were reported in December, January, and November. This could be due to increased social activities and gatherings during the holiday period, which may lead to more encounters with dogs. The findings highlight the need for targeted preventive measures and public awareness campaigns, particularly focused on high-risk groups like children and young adults. Promoting responsible pet ownership and early medical intervention for dog bite victims are also recommended to address this significant public health concern. [ABSTRACT FROM AUTHOR]

Many domestic animals have a profound impact on endangered species through complex interactions and spillover effects in and between coupled human and natural systems. A thorough understanding of the driving forces of human decisions regarding how domestic animals are kept is therefore critical to promote the synergy of human livelihood and biodiversity conservation. Working in the Qinling Mountains of China, we conducted a multidisciplinary study using a structural equation model (SEM) to link households' demographic and economic conditions, peoples attitudes and activities with their decisions, and further investigated how such process influences the potential negative impact of free‐ranging dogs on wildlife. Among 139 blood and saliva samples collected from dogs that were owned by local villagers but allowed to roam freely, 33.3% were positive for at least one of three viral infections, including canine distemper (28.2%), canine parvovirus (25.6%), and rabies virus prevalence (10.3%). SEM modeling revealed that human activity (β = 0.27, p =.012) has significantly increased dogs' potential negative impacts on wildlife by increasing the number of dogs and their direct contact with wildlife, as well as their larger movement range. Conversely, improvement in demographic and economic conditions (β = −0.22, p =.011) and human attitudes (β = −0.51, p =.013) suppresses the influence of free roaming dogs on wildlife. Meanwhile, livelihoods dependent on natural resources increased the likelihood of owners having dog practice that may negatively impact wildlife (β = 0.54, p <.001), without improving the economic conditions of the residents (β = −0.26, p <.001). Based on the above results, we recommend a program that combines educational and conservation efforts to encourages local residents in more responsible dog ownership and recommend reserve managers provide financial incentives to mitigate human‐wildlife conflicts. [ABSTRACT FROM AUTHOR]

• Dioscorea bulbifera L. is well known for its diverse chemical composition and medicinal applications. • This systemic review covers the ethnobotany, phytochemistry, pharmacological importance and toxicity of D. bulbifera L. • Various clinical studies included in this review validate the folk usage of this herb. • The findings presented herein provide a stepping stone for future investigations into the mechanism of action of the formulations or metabolites derived from it and delve into their potential as pharmaceutical agents. Dioscorea bulbifera L. (Dioscoreaceae) is extensively being used in African, Chinese and Indian traditional medicinal systems since ages. It is an ingredient in many herbal and Ayurvedic preparations that are used against various ailments. The current study is aimed to systematically review and document findings on ethnobotany, phytochemistry, pharmacology, nutritive value and toxicity of the herb. The study is intended to overcome the inconsistency between the traditional and pharmacological applications of the herb concerning its folkloric use and offer novel insights for future researchers. The literature was systematically collected from various offline and online sources using relevant keywords. Electronic databases including Google Scholar, PubMed, Science Direct, Springer Online, Research Gate, Scopus etc. were used to retrieve the relevant information. D. bulbifera L. is widespread in tropical and temperate regions of Asia, Africa and America. In traditional medicinal systems, it is used widely to cure sore throat, skin diseases, ulcers, boils, piles, pain, inflammation, dog bites, snake bites, food poisoning, asthma, cough, tuberculosis, cold, jaundice, malaria, typhoid of children, contraceptives, diabetes, ophthalmia, pink eye conjunctivitis etc. Among bioactive constituents, aglycone types of steroidal saponins dioscorin(e), dioscin(e), diosbulbin, and diosgenin possess significant biological activities. The chemical structures of the phytoconstituents presented in this review are drawn using ChemDraw Ultra software. The clinical studies included in this review have been performed to validate the folk usage of this herb. However, more studies are required to be done on scientific and clinical aspects to support its therapeutic applications. The updated information provided in this systematic review would open new perspectives for performing in-depth analysis of pharmacological research in future. The study would be useful for improving the clinical use of the herb and is surely going to bridge a gap between the traditional and modern use of scientific research for future researchers. [ABSTRACT FROM AUTHOR]

Introduction: Rabies is known as acute, highly fatal, hydrophobic viral disease of CNS system. Majority (99%) spread by Dog bite which is major public health problem in rural than urban area. In India17.4 million cases and 24,000 deaths occur every year, each second there is one dog bite. It is 100% preventable disease if all efforts must be made by the health system to prevent even a single case of rabies, by make plans and policies for its prevention under rabies control program. To look into socio-demographic profile, knowledge and practice among dog bite patients registered at PHC-Hiresavalagi, Hence the current study was taken. Objectives: 1. To find the socio-demographic profile of dog bite patients. 2. To assess the Knowledge and Practice of dog bite wound management among dog bite patients. Methodology: A cross sectional study was conducted among all dog bite patients at rural health training centre, Hiresavalagi for period of 7 months by census sampling method. The data was collected by using a predesigned and pretested questionnaire A contact number was obtained from dog bite register, we conducted interview through telephone and who are not respondents to telephone we were approached directly.the data was entered into Microsoft Excel sheet and will be analysed using software SPSS version 16.0. Results and Conclusion: Our study found that 106(93.8%),7(6.2%) was inadequate & adequate knowledge and 82(72.6%), 31(27.4%) was inadequate & adequate practice respectively. Majority 76(67.2%) Patients completed course of treatment, 36(31.9%) was lost to treatment and follow up due to work load, out of station and 1(0.9%) developed new symptoms during the course of treatment. Various control and preventive measures are taken under rabies control program along with health education and promotion, among population by using mass medias, advertisements, role plays & skits at community level. To complete course of treatment strict guidelines should follow at all Health training centre, hospitals & peoples. [ABSTRACT FROM AUTHOR]