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1. Associations between Developmental Exposure to Environmental Contaminants and Spatial Navigation in Late Adolescence

Author

Bastien, Kevin, Muckle, Gina, Ayotte, Pierre, Courtemanche, Yohann, Dodge, Neil C., Jacobson, Joseph L., Jacobson, Sandra W., and Saint-Amour, Dave

Abstract

Inuit communities in Northern Quebec (Canada) are exposed to environmental contaminants, particularly to mercury, lead and polychlorinated biphenyls (PCBs). Previous studies reported adverse associations between these neurotoxicants and memory performance. Here we aimed to determine the associations of pre- and postnatal exposures to mercury, lead and PCB-153 on spatial navigation memory in 212 Inuit adolescents (mean age = 18.5 years) using a computer task which requires learning the location of a hidden platform based on allocentric spatial representation. Contaminant concentrations were measured in cord blood at birth and blood samples at 11 years of age and at time of testing. Multivariate regression models showed that adolescent mercury and prenatal PCB-153 exposures were associated with poorer spatial learning, whereas current exposure to PCB-153 was associated with altered spatial memory retrieval at the probe test trial. These findings suggest that contaminants might be linked to different aspects of spatial navigation processing at different stages.

Published
2022
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2. Reading Impairment in Adolescents with Fetal Alcohol Spectrum Disorders

Author

Lindinger, Nadine M., Jacobson, Sandra W., Davidson, Landi, Conradie, Simone, Dodge, Neil C., Molteno, Christopher D., Meintjes, Ernesta M., Gaab, Nadine, and Jacobson, Joseph L.

Abstract

Purpose: To date, research on effects of prenatal alcohol exposure (PAE) has focused on a broad range of cognitive impairments, but relatively few studies have examined effects of PAE on development of reading skills. Although PAE has been linked to poorer reading comprehension, it remains unclear whether this impairment is attributable to deficits in phonological processing, word reading, oral language skills, and/or executive functioning. Methods: A comprehensive reading battery was administered to 10 adolescents with fetal alcohol syndrome (FAS); 16 with partial FAS; 30 nonsyndromal heavily exposed; 49 controls. Results: PAE was related to poorer reading comprehension but not to singleword reading or phonological processing, suggesting that the mechanics of reading are intact in adolescents with fetal alcohol spectrum disorders at this age. PAE-related impairment in reading comprehension was mediated, in part, by deficits in mastery of oral language skills, including vocabulary, language structure, and verbal fluency. Conclusions: These results are consistent with research showing that reading comprehension in adolescence relies increasingly on linguistic comprehension abilities, especially once word reading becomes automatic and text complexity increases. Our findings suggest that reading-impaired adolescents with PAE will benefit from intervention programs targeting vocabulary knowledge, language structure, verbal fluency, and reading comprehension skills.

Published
2022
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3. Genetic admixture predictors of fetal alcohol spectrum disorders (FASD) in the South African Cape Coloured population

Author

Carter, R. Colin, primary, Yang, Zikun, additional, Akkaya-Hocagil, Tugba, additional, Jacobson, Sandra W., additional, Jacobson, Joseph L., additional, Dodge, Neil C., additional, Hoyme, H. Eugene, additional, Zeisel, Steven, additional, Meintjes, Ernesta M., additional, Kizil, Caghan, additional, and Tosto, Giuseppe, additional

Published
2024
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4. A dose-response analysis of the effects of prenatal alcohol exposure on cognitive development.

Author

Jacobson, Joseph L., Akkaya-Hocagil, Tugba, Jacobson, Sandra W., Coles, Claire D., Richardson, Gale A., Olson, Heather Carmichael, Day, Nancy L., Carter, R. Colin, Dodge, Neil C., Khue-Dung Dang, Cook, Richard J., and Ryan, Louise M.

Subjects
READING, INFANT development, PRENATAL exposure delayed effects, COGNITIVE testing, SECONDARY analysis, MATHEMATICS, RESEARCH funding, MULTIPLE regression analysis, PROBABILITY theory, CHILD health services, EXECUTIVE function, PARENTING, LEARNING, DESCRIPTIVE statistics, DOSE-response relationship in biochemistry, FETAL alcohol syndrome, ACHIEVEMENT tests, ALCOHOL drinking, SUBSTANCE abuse in pregnancy, ALCOHOLISM, FACTOR analysis, MOTHERHOOD, PSYCHOLOGICAL tests, NONPARAMETRIC statistics, PREGNANCY
Abstract

Background: Most studies of the effects of prenatal alcohol exposure (PAE) on cognitive function have assumed that the dose-response curve is linear. However, data from a few animal and human studies suggest that there may be an inflection point in the dose-response curve above which PAE effects are markedly stronger and that there may be differences associated with pattern of exposure, assessed in terms of alcohol dose per drinking occasion and drinking frequency. Methods: We performed second-order confirmatory factor analysis on data obtained at school age, adolescence, and early adulthood from 2227 participants in six US longitudinal cohorts to derive a composite measure of cognitive function. Regression models were constructed to examine effects of PAE on cognitive function, adjusted for propensity scores. Analyses based on a single predictor (absolute alcohol (AA)/day) were compared with analyses based on two predictors (dose/occasion and drinking frequency), using (1) linear models and (2) nonparametric general additive models (GAM) that allow for both linear and nonlinear effects. Results: The single-predictor GAM model showed virtually no nonlinearity in the effect of AA/day on cognitive function. However, the two-predictor GAM model revealed differential effects of maternal drinking pattern. Among offspring of infrequent drinkers, PAE effects on cognitive function were markedly stronger in those whose mothers drank more than ~3 drinks/occasion, and the effect of dose/occasion was strongest among the very frequent drinkers. Frequency of drinking did not appear to alter the PAE effect on cognitive function among participants born to mothers who limited their drinking to ~1 drink/occasion or less. Conclusions: These findings suggest that linear models based on total AA/day are appropriate for assessing whether PAE affects a given cognitive outcome. However, examination of alcohol dose/occasion and drinking frequency is needed to fully characterize the impact of different levels of alcohol intake on cognitive impairment. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Alterations in Placental Inflammation-Related Gene Expression Partially Mediate the Effects of Prenatal Alcohol Consumption on Maternal Iron Homeostasis

Author

Masehi-Lano, Jacqueline J., primary, Deyssenroth, Maya, additional, Jacobson, Sandra W., additional, Jacobson, Joseph L., additional, Molteno, Christopher D., additional, Dodge, Neil C., additional, Wainwright, Helen C., additional, Meintjes, Ernesta M., additional, Lesseur, Corina, additional, Cheng, Haoxiang, additional, Li, Qian, additional, Hao, Ke, additional, Chen, Jia, additional, and Carter, R. Colin, additional

Published
2023
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7. Effects of Prenatal Alcohol Exposure on Testosterone and Pubertal Development

Author

Carter, R Colin, Jacobson, Joseph L, Dodge, Neil C, Granger, Douglas A, and Jacobson, Sandra W

Subjects
Contraception/Reproduction, Substance Misuse, Pediatric, Clinical Research, Conditions Affecting the Embryonic and Fetal Periods, Alcoholism, Alcohol Use and Health, Neurosciences, Reproductive health and childbirth, Cancer, Good Health and Well Being, Adolescent, Adult, Alcohol Drinking, Ethanol, Female, Humans, Male, Pregnancy, Prenatal Exposure Delayed Effects, Puberty, Saliva, Testosterone, Fetal Alcohol Spectrum Disorder, Prenatal Alcohol Exposure, Tanner Stages, Clinical Sciences, Psychology, Substance Abuse
Abstract

BackgroundAnimal models have demonstrated fetal alcohol-related disruptions in neuroendocrine function in the hypothalamic-pituitary-gonadal axis and downstream effects on pubertal development and sexual behavior in males and females, but little is known about these effects in humans. This study examined whether prenatal alcohol exposure is associated with alterations in testosterone during adolescence and whether it affects timing of pubertal development.MethodsThe sample consisted of 265 African American adolescents from the Detroit Longitudinal Cohort Study for whom testosterone and/or pubertal development data were available. Subjects were offspring of women recruited at their first prenatal clinic visit to over represent moderate-to-heavy alcohol use, including a 5% random sample of low-level drinkers/abstainers. Mothers were interviewed at every prenatal visit about their alcohol consumption using a timeline follow-back approach and about their smoking and drug use and sociodemographic factors. At age 14 years, adolescents provided salivary samples, which were analyzed for testosterone (pg/ml), self-reported Tanner stages for pubertal development, and age at menarche (females).ResultsPrenatal alcohol exposure was related to elevated testosterone concentrations for males and females but not to changes in Tanner stages or age at menarche, after controlling for confounders. In regression models stratified by alcohol exposure, the expected relation between testosterone and pubic hair development was seen among males with light-to-no prenatal alcohol exposure, but not among those with moderate-to-heavy prenatal alcohol exposure. This interaction between testosterone and prenatal alcohol exposure was confirmed in multivariable models including an alcohol exposure group × testosterone interaction term and potential confounders.ConclusionsThis study is the first to show a relation between prenatal alcohol exposure and increased testosterone during adolescence and evidence of decreased testosterone responsiveness in tissues related to pubertal development in humans. Further studies examining androgen receptor expression and other hormonal and cellular factors affecting pubertal development may reveal important mechanisms underlying these teratogenic effects of alcohol exposure.

Published
2014

20. List of Contributors

Author

Abadie-Guedes, Ricardo, primary, Abi-Dargham, Anissa, additional, Abulseoud, Osama A., additional, Acevska, Jelena, additional, Adan, Ana, additional, Aguilar, María A., additional, Akhgari, Maryam, additional, Ali, Robert, additional, Anderson-Mooney, Amelia J., additional, Anees, Muhammad, additional, Arenas, M. Carmen, additional, Arndt, Jamie, additional, Ascheri, Daniele, additional, Ashraf, Nida, additional, Ashton, Maxie, additional, Asimaki, Olga, additional, Aubry, Jean-Michel, additional, Aujla, Harinder, additional, Awad, A. George, additional, Awara, Mahmoud A., additional, Bagues, Ana, additional, Balhara, Yatan P.S., additional, Bambico, Francis, additional, Barrio-Real, Laura, additional, Bartlett, Selena E., additional, Basavarajappa, Balapal S., additional, Basu, Aniruddha, additional, Bau, Claiton H.D., additional, Beattie, Matthew C., additional, Becker, Benjamin, additional, Beer, Anton L., additional, Behera, Deepak, additional, Benaiges, Irina, additional, Bergen-Cico, Dessa, additional, Bergeson, Susan E., additional, Berrettini, Wade H., additional, Bertoglio, Leandro J., additional, Bockman, Charles S., additional, Borgwardt, Stefan, additional, Bourque, Josiane, additional, Bozkurt, Muge, additional, Brennan, Katharine Alexandra, additional, Briggs, Hilary, additional, Brooks, Samanth J., additional, Bulcão, Rachel Picada, additional, Burkhardt, Ute, additional, Butler, Tracy R., additional, Cabrera, Eduardo Rodrigues, additional, Caldirola, Daniela, additional, Callaghan, Russell C., additional, Callegari, Elza, additional, Caloca, María J., additional, Campos, Alline C., additional, Cannizzaro, Carla, additional, Cape, Gavin, additional, Carnell, Benjamin L., additional, Caso, Javier R., additional, Cendron, Lucas Henrique, additional, Chang, Yun-Hsuan, additional, Cheng, Gordon L.F., additional, Chen, Kao Chin, additional, Chopra, Kanwaljit, additional, Chow, Tony C.H., additional, Cico, Rachael, additional, Cook, Jason B., additional, Coppola, Maurizio, additional, Cortes-Briones, Jose A., additional, Cousijn, Janna, additional, Crist, Richard C., additional, Crocker, Candice E., additional, Danielson, Kirsty, additional, Dasilva, Miguel, additional, Dave, Malay, additional, De Biasi, Mariella, additional, de Carvalho, Cristiane R., additional, De Guio, François, additional, De Ridder, Dirk, additional, Dhiman, Sonia, additional, Diaferia, Giuseppina, additional, Diana, Marco, additional, DiFranza, Joseph R., additional, Dimitrovska, Aneta, additional, Dinh-Williams, Le-Anh, additional, Djurendic-Brenesel, Maja, additional, Dodd, Jonathan N., additional, Dodge, Neil C., additional, Drew, Paul D., additional, Drucker Colín, Rene, additional, Dujmovic, Irena, additional, Dutra Arbo, Marcelo, additional, Edwards, Scott, additional, Etemadi-Aleagha, Afshar, additional, Evren, Cuneyt, additional, Fang, Juan, additional, Fernández-Rodríguez, Camino, additional, Filipovic, Radmila, additional, Finsterer, Josef, additional, Fitzgerald, Megan L., additional, Fogaça, Manoela V., additional, Forero, Diego A., additional, Fouad Moselhy, Hamdy, additional, Freitas, Marco Antonio de, additional, Galletly, Cherrie, additional, García-Bueno, Borja, additional, Gatley, Jodi M., additional, Germanaud, David, additional, Gifford, Roger S., additional, Glue, Paul, additional, Gobbi, Gabriella, additional, Goicoechea, Carlos, additional, González-Arnay, Emilio, additional, González-Reimers, Emilio, additional, González-Sarmiento, Rogelio, additional, Gowing, Linda, additional, Grieve, Kenneth L., additional, Guedes, Rubem Carlos Araújo, additional, Guerri, Consuelo, additional, Guimarães, Francisco S., additional, Guller, Leila, additional, Harland, Jennifer, additional, Hashemi, Seyyed A., additional, Hashemizadeh, Shiva, additional, He, Bei, additional, Hernández-López, Salvador, additional, Hickle, Tyson, additional, Hill, Shirley Y., additional, Holgate, Joan, additional, Huang, Wei, additional, Huang, Wei-Lieh, additional, Hunt, Nicholas J., additional, Hurlemann, René, additional, Iannone, Giuseppe, additional, Idrees, Fariha, additional, Idrees, Jawaria, additional, Ikeda, Kazutaka, additional, Ivanashvili, Nato, additional, Ivanov, Iliyan, additional, Jacobson, Joseph L., additional, Jacobson, Sandra W., additional, Järbe, Torbjörn U.C., additional, Jiang, Y.L., additional, Jokar, Farzaneh, additional, Kane, Cynthia J.M., additional, Kangiser, Megan, additional, Karpyak, Victor, additional, King, Jean A., additional, Kivell, Bronwyn M., additional, Kiyatkin, Eugene A., additional, Klein, Jochen, additional, Klima, Michelle L., additional, Kodirov, Sodikdjon A., additional, Korostynski, Michal, additional, Kreek, Mary Jeanne, additional, Kulevanova, Svetlana, additional, Kumar, Santosh, additional, Langguth, Berthold, additional, Leal, Mirna Bainy, additional, Lee, Sheng-Yu, additional, Lee, Tatia M.C., additional, Leikaif, John, additional, Lin, Shih-Hsien, additional, Lin, Yu-Hsuan, additional, Liu, Xiu, additional, Lorenzetti, Valentina, additional, Lu, Ru-Band, additional, Machaalani, Rita, additional, Maldonado-Devincci, Antoniette, additional, Mangin, Jean-François, additional, Mangoura, Dimitra, additional, Manning, Patrick, additional, Marcu, Jahan P., additional, McCabe, Simon, additional, McGinn, M. Adrienne, additional, McKinney, Diana L., additional, McLaughin, Ryan, additional, McLaughlin, Ian, additional, Meintjes, Ernesta, additional, Midde, Narasimha M., additional, Mihailescu, Stefan, additional, Miñarro, José, additional, Mondola, Raffaella, additional, Leslie Morrow, A., additional, Mota, Nina R., additional, Newcorn, Jeffrey, additional, Nishizawa, Daisuke, additional, Nobrega, José N., additional, Nona, Christina N., additional, Nuñez, Nicolas, additional, Nylander, Ingrid, additional, O’Brien, Jessica W., additional, Oliva, Francesco, additional, Palm, Sara, additional, Papini, Mauricio R., additional, Park, Byung Lae, additional, Pascual, María, additional, Pedraza, Juan, additional, Perna, Giampaolo, additional, Picci, Rocco Luigi, additional, Piechota, Marcin, additional, Pilija, Vladimir, additional, Pinto, Charles, additional, Potvin, Stéphane, additional, Prasad Rawat, Jagdeo, additional, Preedy, Victor R., additional, Priddy, Brittany M., additional, Przewlocki, Ryszard, additional, Raghav, Jimit G., additional, Rajendram, Rajkumar, additional, Rajendram, Roshanna, additional, Rao, P.S.S., additional, Ray, Anirban, additional, Rezayof, Ameneh, additional, Rivadulla, Casto, additional, Rodríguez-Arias, Marta, additional, Rossato, Luciana Grazziotin, additional, Rovaris, Diego L., additional, Ruby, Christina L., additional, Sakellaridis, Nikos, additional, Salman, Saad, additional, Santolaria-Fernández, Francisco, additional, Sarkar, Siddharth, additional, Schechter, Jason B., additional, Schmidt, André, additional, Scholl, Susan, additional, Scott, April, additional, Shariff, Masroor, additional, Sharma, Shiwali, additional, Shin, Hyoung Doo, additional, Singh, Thakur Gurjeet, additional, Sinha, Namita, additional, Skosnik, Patrick D., additional, Bezerra, Ranilson de Souza, additional, Stairs, Dustin J., additional, Stefkov, Gjoshe, additional, Stein, Dan J., additional, Stern, Cristina A.J., additional, Stöllberger, Claudia, additional, Takahashi, Reinaldo N., additional, Tang, H.C., additional, Tarren, Josephine, additional, Tibbo, Philip G., additional, Tiwari, Vinod, additional, Torres, Carmen, additional, Trivelli, Federica, additional, Truman, Penelope, additional, Tsirimonaki, Emmanouella, additional, Vanneste, Sven, additional, Vansickel, Andrea R., additional, Vendruscolo, Leandro F., additional, Wai, Maria S.M., additional, Walter, Marc, additional, Waters, Karen A., additional, Weiner, Jeffrey L., additional, Weinstein, Jodi J., additional, Weisberg, Jordyn, additional, Whitaker, Annie M., additional, Wolf-Stanton, Sarah, additional, Wu, Chen-Ying, additional, Wu, Sharon L., additional, Yang, Cheryl C.H., additional, Yang, Yen Kuang, additional, Yeshwant Tandel, Kirti, additional, Yew, D.T., additional, Yousefzadeh Fard, Yashar, additional, and Zhou, Yan, additional

Published
2016
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25. Effects of prenatal alcohol exposure on cognitive and behavioral development: Findings from a hierarchical meta‐analysis of data from six prospective longitudinal U.S. cohorts

Author

Jacobson, Joseph L., primary, Akkaya‐Hocagil, Tugba, additional, Ryan, Louise M., additional, Dodge, Neil C., additional, Richardson, Gale A., additional, Olson, Heather Carmichael, additional, Coles, Claire D., additional, Day, Nancy L., additional, Cook, Richard J., additional, and Jacobson, Sandra W., additional

Published
2021
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26. Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes

Author

Warton, Fleur L., primary, Molteno, Christopher D., additional, Warton, Christopher M. R., additional, Wintermark, Pia, additional, Lindinger, Nadine M., additional, Dodge, Neil C., additional, Zöllei, Lilla, additional, Kouwe, Andre J.W., additional, Carter, R. Colin, additional, Jacobson, Joseph L., additional, Jacobson, Sandra W., additional, and Meintjes, Ernesta M., additional

Published
2021
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41. Deficits in arithmetic error detection in infants with prenatal alcohol exposure: An ERP study

Author

Berger, Andrea, primary, Shmueli, Michael, additional, Lisson, Svetlana, additional, Ben-Shachar, Mattan S., additional, Lindinger, Nadine M., additional, Lewis, Catherine E., additional, Dodge, Neil C., additional, Molteno, Christopher D., additional, Meintjes, Ernesta M., additional, Jacobson, Joseph L., additional, and Jacobson, Sandra W., additional

Published
2019
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49. Alcohol-Related Alterations in Placental Imprinted Gene Expression in Humans Mediate Effects of Prenatal Alcohol Exposure on Postnatal Growth

Author

Carter, R. Colin, primary, Chen, Jia, additional, Li, Qian, additional, Deyssenroth, Maya, additional, Dodge, Neil C., additional, Wainwright, Helen C., additional, Molteno, Christopher D., additional, Meintjes, Ernesta M., additional, Jacobson, Joseph L., additional, and Jacobson, Sandra W., additional

Published
2018
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50. Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Author

Jacobson, Sandra W., primary, Carter, R. Colin, additional, Molteno, Christopher D., additional, Stanton, Mark E., additional, Herbert, Jane S., additional, Lindinger, Nadine M., additional, Lewis, Catherine E., additional, Dodge, Neil C., additional, Hoyme, H. Eugene, additional, Zeisel, Steven H., additional, Meintjes, Ernesta M., additional, Duggan, Christopher P., additional, and Jacobson, Joseph L., additional

Published
2018
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