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Background and Aims: Diabetes has been reported to be a risk factor for sleep disturbances in adolescent age groups. Although the impact of type1 diabetes mellitus (T1DM) on sleep patterns of children is well recognized, data about its prevalence is scant. This study aims to determine the quality of sleep among adolescents with T1DM and factors inuencing it. Methods: This is a cross-sectional study collected data from 30 adolescent diagnosed with T1DM at least 6 months earlier. They presented to Paediatric endocrine OPD from May 2021 to May 2022. Subjects were asked to complete the Pittsburgh Sleep Quality Index (PSQI) 19-item self-report questionnaire. Children with T1DM being under treatment for sleep disorder were excluded. The combined score of the 7 components (subjective sleep quality, sleep latency, sleep duration, habitual sleep efciency, sleep disturbances, use of sleeping medication, and daytime dysfunction) was used for analysis and the score ranged from 0 to 21. Atotal score >5 was considered as “poor sleep quality”. The quality of sleep was correlated with drug, dietary compliance and metabolic control. p-value 5). No signicant relationship was found between sleep quality, duration of diabetes and HbA1c levels in the diabetes group (P= 0.59, P= 0.41, respectively). The total sleep time of boys (8.4 ± 1.2 h) was longer than girls (7.6 ± 1.7 h), but the overall total sleep time per night did not differ signicantly between boys and girls (P= 0.053). Conclusion: The present study shows that diabetes control may affect sleep quality in adolescents. Optimal diabetes management can positively affect sleep patterns in these adolescents. Further larger studies are needed to validate our results

A field experiment on the effectiveness of seed treatment and foliar application of insecticides againstsoybean stem fly Melanagromyza sojae (Zehntner) was carried out at the All India Coordinated ResearchProject (AICRP) on Soybean, Gandhi Krishi Vignan Kendra (GKVK), Bengaluru, Karnataka duringkharif 2017. The seeds treated with thiamethoxam 30FS @ 10 ml/kg seed and foliar application ofthiamethoxam 25WG 0.40 g/ l at 30 days after germination (DAG) were found effective. It was on par withseeds treated with imidacloprid 48FS @ 1.25 ml/ kg seed and foliar application of imidacloprid 17.8SL@ 0.50 ml/ l at 30 DAG. The plots treated with these gave higher grain yield of 1794.48 and 1678.89 kg/ha, respectively. Higher net gain of 1: 4.22 was obtained from the seeds treated with thiamethaxom 30FS@ 10 ml/ kg seed and foliar application of thiamethoxam 25WG 0.40 g/ l at 30 DAG; and it proved to behighly cost effective. The foliar application of chlorantraniliprole 18.5SC @ 0.30 ml/ l at 10 and 30 DAGwas equally effective compared to thiamethoxam and recorded the C: B ratio of 1: 3.94. The plots treatedwith quinalphos 25EC @ 2 ml/ l at 10 and 30 DAG led to the least stem tunneling of (26.73%) and thelow grain yield of 1177.78 kg/ ha.

Natural products, natural product-inspired molecules and natural product derivatives have contributed around 79% to the new chemotherapies against the most complex, deadly disease, cancer. In this study, a series of novel isoxazoline derivatives of Goniodiol diacetate (fused bicyclic pyranone isoxazoline derivatives)- a natural product derivative, were synthesized with quantitative yield as a single regioisomer by 1,3 - dipolar cycloaddition reaction with different aldoximes. The regiospecific product formed was confirmed by NOESY study and single-crystal X-ray diffraction. The regiospecificity of the product formation was further explained by coefficients of selected atomic orbitals in frontier molecular orbitals and natural population analysis (NPA in eV) of dipolarophile and dipole by density functional theory studies. All the derivatives have demonstrated anti-cancer activity selectively in human breast cancer (MDA-MB-231), ovarian cancer (SKOV3), prostate cancer (PC-3) and colon cancer (HCT-15) cell lines with EC

Stem rot (Sclerotium rolfsii Sacc.) of capsicum which is also called as collar rot or southern blight is one of the serious diseases in capsicum that severely brings down the yield in all the major capsicum growing areas in Karnataka. Among the several management practices, managing the disease with fungicides is the most effective means. In the present investigation twelve fungicides that included three systemic, six combi products and three contact fungicides were evaluated against S. rolfsii in vitro. Among the fungicides, hexaconazole, difenoconazole, propiconazole, propiconazole + difenoconazole, tricyclazole + hexaconazole, hexaconazole + captan, zineb + hexaconazole and thiram were highly effective even at least concentration of 25 ppm tested and also in subsequent concentrations of 50 ppm, 100 ppm, 250 ppm, 500 ppm showing 100 per cent inhibition. Further, among the eight promising fungicides based on in vitro results, six fungicides were evaluated against stem rot of capsicum under polyhouse conditions. Among the treatments undertaken, propiconazole and difenoconazole each at 0.1 per cent were effective resulting in 97.05 per cent reduction in disease over control and can be concluded as promising fungicides against stem rot.

Tracheal length and lung anatomy have been rarely studied; however, the anatomy of the lung has been shown to vary significantly. Moreover, the surgery regarding trachea are few, and hence the surgeons do not have extensive experience in the trachea.We aimed to study the variations of the lung anatomy and the relation between tracheal length and body height in the Indian population.This is an observational study to observe the tracheal length in relation to body height and sex and gross morphological anatomy of the lung in 70 cadavers. The data was collected from the forensic department of Bangalore Medical College and Research Institute (BMCRI), and further analysis was done at Kidwai Memorial Institute of Oncology.Deviation from normal lung morphology was seen in 37.86% of the specimens studied. The tracheal length (average, 9.97 cm) correlated with the body length (average, 147.02 cm) with a Pearson coefficient of 0.806 (p value=0.001) Conclusion: The study of lung fissure morphology guides clinicians in understanding and planning lung disease treatment, especially lobectomy/segmentectomy surgeries. The information of the average length of the trachea with respect to body height in a given ethnicity will help during endotracheal intubation and tracheal surgical planning.

The drugs prescribed for targeting the tumour growth comprise of chemotherapy regimen involving combinations to cell-cycle phase specific target receptors. The combination therapy with Topoisomerase-I (Topo-I)anti-tubulin agents are in the clinical trial stages and have scope for identifying new chemical entities with dual binding and inhibiting potential. The checkpoint proteins present at the interface of cell-cycle phases are considered the link between these two that establish the connectivity across the two phases of cell-cycle. In the present study, this potential cross-link or dual targeting is explored via