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6. Tendon Aging

Author

Graça, Ana Luísa, Gomez-Florit, Manuel, Gomes, Manuela Estima, Docheva, Denitsa, Harris, J. Robin, Series Editor, Kundu, Tapas K., Advisory Editor, Korolchuk, Viktor, Advisory Editor, Bolanos-Garcia, Victor, Advisory Editor, Marles-Wright, Jon, Advisory Editor, and Korolchuk, Viktor I., editor

Published
2023
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8. Sclerostin modulates mineralization degree and stiffness profile in the fibrocartilaginous enthesis for mechanical tissue integrity

Author

Yambe, Shinsei, primary, Yoshimoto, Yuki, additional, Ikeda, Kazutaka, additional, Maki, Koichiro, additional, Takimoto, Aki, additional, Tokuyama, Akihide, additional, Higuchi, Shinnosuke, additional, Yu, Xinyi, additional, Uchibe, Kenta, additional, Miura, Shigenori, additional, Watanabe, Hitomi, additional, Sakuma, Tetsushi, additional, Yamamoto, Takashi, additional, Tanimoto, Kotaro, additional, Kondoh, Gen, additional, Kasahara, Masataka, additional, Mizoguchi, Toshihide, additional, Docheva, Denitsa, additional, Adachi, Taiji, additional, and Shukunami, Chisa, additional

Published
2024
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13. Supplementary Video 2 from Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics

Author

Kuric, Martin, primary, Beck, Susanne, primary, Schneider, Doris, primary, Rindt, Wyonna, primary, Evers, Marietheres, primary, Meißner-Weigl, Jutta, primary, Zeck, Sabine, primary, Krug, Melanie, primary, Herrmann, Marietta, primary, Hartmann, Tanja Nicole, primary, Leich, Ellen, primary, Rudert, Maximilian, primary, Docheva, Denitsa, primary, Seckinger, Anja, primary, Hose, Dirk, primary, Jundt, Franziska, primary, and Ebert, Regina, primary

Published
2024
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14. TABLE 1 from Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics

Author

Kuric, Martin, primary, Beck, Susanne, primary, Schneider, Doris, primary, Rindt, Wyonna, primary, Evers, Marietheres, primary, Meißner-Weigl, Jutta, primary, Zeck, Sabine, primary, Krug, Melanie, primary, Herrmann, Marietta, primary, Hartmann, Tanja Nicole, primary, Leich, Ellen, primary, Rudert, Maximilian, primary, Docheva, Denitsa, primary, Seckinger, Anja, primary, Hose, Dirk, primary, Jundt, Franziska, primary, and Ebert, Regina, primary

Published
2024
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15. Data from Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics

Author

Kuric, Martin, primary, Beck, Susanne, primary, Schneider, Doris, primary, Rindt, Wyonna, primary, Evers, Marietheres, primary, Meißner-Weigl, Jutta, primary, Zeck, Sabine, primary, Krug, Melanie, primary, Herrmann, Marietta, primary, Hartmann, Tanja Nicole, primary, Leich, Ellen, primary, Rudert, Maximilian, primary, Docheva, Denitsa, primary, Seckinger, Anja, primary, Hose, Dirk, primary, Jundt, Franziska, primary, and Ebert, Regina, primary

Published
2024
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16. Supplementary Video 3 from Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics

Author

Kuric, Martin, primary, Beck, Susanne, primary, Schneider, Doris, primary, Rindt, Wyonna, primary, Evers, Marietheres, primary, Meißner-Weigl, Jutta, primary, Zeck, Sabine, primary, Krug, Melanie, primary, Herrmann, Marietta, primary, Hartmann, Tanja Nicole, primary, Leich, Ellen, primary, Rudert, Maximilian, primary, Docheva, Denitsa, primary, Seckinger, Anja, primary, Hose, Dirk, primary, Jundt, Franziska, primary, and Ebert, Regina, primary

Published
2024
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17. FIGURE 1 from Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics

Author

Kuric, Martin, primary, Beck, Susanne, primary, Schneider, Doris, primary, Rindt, Wyonna, primary, Evers, Marietheres, primary, Meißner-Weigl, Jutta, primary, Zeck, Sabine, primary, Krug, Melanie, primary, Herrmann, Marietta, primary, Hartmann, Tanja Nicole, primary, Leich, Ellen, primary, Rudert, Maximilian, primary, Docheva, Denitsa, primary, Seckinger, Anja, primary, Hose, Dirk, primary, Jundt, Franziska, primary, and Ebert, Regina, primary

Published
2024
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18. Supplementary Video 1 from Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics

Author

Kuric, Martin, primary, Beck, Susanne, primary, Schneider, Doris, primary, Rindt, Wyonna, primary, Evers, Marietheres, primary, Meißner-Weigl, Jutta, primary, Zeck, Sabine, primary, Krug, Melanie, primary, Herrmann, Marietta, primary, Hartmann, Tanja Nicole, primary, Leich, Ellen, primary, Rudert, Maximilian, primary, Docheva, Denitsa, primary, Seckinger, Anja, primary, Hose, Dirk, primary, Jundt, Franziska, primary, and Ebert, Regina, primary

Published
2024
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19. Supplementary Table 1 from Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics

Author

Kuric, Martin, primary, Beck, Susanne, primary, Schneider, Doris, primary, Rindt, Wyonna, primary, Evers, Marietheres, primary, Meißner-Weigl, Jutta, primary, Zeck, Sabine, primary, Krug, Melanie, primary, Herrmann, Marietta, primary, Hartmann, Tanja Nicole, primary, Leich, Ellen, primary, Rudert, Maximilian, primary, Docheva, Denitsa, primary, Seckinger, Anja, primary, Hose, Dirk, primary, Jundt, Franziska, primary, and Ebert, Regina, primary

Published
2024
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20. Supplementary Table 3 from Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics

Author

Kuric, Martin, primary, Beck, Susanne, primary, Schneider, Doris, primary, Rindt, Wyonna, primary, Evers, Marietheres, primary, Meißner-Weigl, Jutta, primary, Zeck, Sabine, primary, Krug, Melanie, primary, Herrmann, Marietta, primary, Hartmann, Tanja Nicole, primary, Leich, Ellen, primary, Rudert, Maximilian, primary, Docheva, Denitsa, primary, Seckinger, Anja, primary, Hose, Dirk, primary, Jundt, Franziska, primary, and Ebert, Regina, primary

Published
2024
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21. Supplementary Methods from Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics

Author

Kuric, Martin, primary, Beck, Susanne, primary, Schneider, Doris, primary, Rindt, Wyonna, primary, Evers, Marietheres, primary, Meißner-Weigl, Jutta, primary, Zeck, Sabine, primary, Krug, Melanie, primary, Herrmann, Marietta, primary, Hartmann, Tanja Nicole, primary, Leich, Ellen, primary, Rudert, Maximilian, primary, Docheva, Denitsa, primary, Seckinger, Anja, primary, Hose, Dirk, primary, Jundt, Franziska, primary, and Ebert, Regina, primary

Published
2024
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22. Supplementary Video 4 from Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics

Author

Kuric, Martin, primary, Beck, Susanne, primary, Schneider, Doris, primary, Rindt, Wyonna, primary, Evers, Marietheres, primary, Meißner-Weigl, Jutta, primary, Zeck, Sabine, primary, Krug, Melanie, primary, Herrmann, Marietta, primary, Hartmann, Tanja Nicole, primary, Leich, Ellen, primary, Rudert, Maximilian, primary, Docheva, Denitsa, primary, Seckinger, Anja, primary, Hose, Dirk, primary, Jundt, Franziska, primary, and Ebert, Regina, primary

Published
2024
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23. Supplementary Table 2 from Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics

Author

Kuric, Martin, primary, Beck, Susanne, primary, Schneider, Doris, primary, Rindt, Wyonna, primary, Evers, Marietheres, primary, Meißner-Weigl, Jutta, primary, Zeck, Sabine, primary, Krug, Melanie, primary, Herrmann, Marietta, primary, Hartmann, Tanja Nicole, primary, Leich, Ellen, primary, Rudert, Maximilian, primary, Docheva, Denitsa, primary, Seckinger, Anja, primary, Hose, Dirk, primary, Jundt, Franziska, primary, and Ebert, Regina, primary

Published
2024
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24. FIGURE 2 from Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics

Author

Kuric, Martin, primary, Beck, Susanne, primary, Schneider, Doris, primary, Rindt, Wyonna, primary, Evers, Marietheres, primary, Meißner-Weigl, Jutta, primary, Zeck, Sabine, primary, Krug, Melanie, primary, Herrmann, Marietta, primary, Hartmann, Tanja Nicole, primary, Leich, Ellen, primary, Rudert, Maximilian, primary, Docheva, Denitsa, primary, Seckinger, Anja, primary, Hose, Dirk, primary, Jundt, Franziska, primary, and Ebert, Regina, primary

Published
2024
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25. FIGURE 6 from Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics

Author

Kuric, Martin, primary, Beck, Susanne, primary, Schneider, Doris, primary, Rindt, Wyonna, primary, Evers, Marietheres, primary, Meißner-Weigl, Jutta, primary, Zeck, Sabine, primary, Krug, Melanie, primary, Herrmann, Marietta, primary, Hartmann, Tanja Nicole, primary, Leich, Ellen, primary, Rudert, Maximilian, primary, Docheva, Denitsa, primary, Seckinger, Anja, primary, Hose, Dirk, primary, Jundt, Franziska, primary, and Ebert, Regina, primary

Published
2024
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26. FIGURE 4 from Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics

Author

Kuric, Martin, primary, Beck, Susanne, primary, Schneider, Doris, primary, Rindt, Wyonna, primary, Evers, Marietheres, primary, Meißner-Weigl, Jutta, primary, Zeck, Sabine, primary, Krug, Melanie, primary, Herrmann, Marietta, primary, Hartmann, Tanja Nicole, primary, Leich, Ellen, primary, Rudert, Maximilian, primary, Docheva, Denitsa, primary, Seckinger, Anja, primary, Hose, Dirk, primary, Jundt, Franziska, primary, and Ebert, Regina, primary

Published
2024
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27. FIGURE 5 from Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics

Author

Kuric, Martin, primary, Beck, Susanne, primary, Schneider, Doris, primary, Rindt, Wyonna, primary, Evers, Marietheres, primary, Meißner-Weigl, Jutta, primary, Zeck, Sabine, primary, Krug, Melanie, primary, Herrmann, Marietta, primary, Hartmann, Tanja Nicole, primary, Leich, Ellen, primary, Rudert, Maximilian, primary, Docheva, Denitsa, primary, Seckinger, Anja, primary, Hose, Dirk, primary, Jundt, Franziska, primary, and Ebert, Regina, primary

Published
2024
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28. Supplementary Figures 1-8 from Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics

Author

Kuric, Martin, primary, Beck, Susanne, primary, Schneider, Doris, primary, Rindt, Wyonna, primary, Evers, Marietheres, primary, Meißner-Weigl, Jutta, primary, Zeck, Sabine, primary, Krug, Melanie, primary, Herrmann, Marietta, primary, Hartmann, Tanja Nicole, primary, Leich, Ellen, primary, Rudert, Maximilian, primary, Docheva, Denitsa, primary, Seckinger, Anja, primary, Hose, Dirk, primary, Jundt, Franziska, primary, and Ebert, Regina, primary

Published
2024
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29. Modelling Myeloma Dissemination in vitro with hMSC-Interacting Subpopulations of INA-6 Cells and their Aggregation/Detachment Dynamics

Author

Kuric, Martin, primary, Beck, Susanne, additional, Schneider, Doris, additional, Rindt, Wyonna, additional, Evers, Marietheres, additional, Meissner-Weigl, Jutta, additional, Zeck, Sabine, additional, Krug, Melanie, additional, Herrmann, Marietta, additional, Hartmann, Tanja Nicole, additional, Leich, Ellen, additional, Rudert, Maximilian, additional, Docheva, Denitsa, additional, Seckinger, Anja, additional, Hose, Dirk, additional, Jundt, Franziska, additional, and Ebert, Regina, additional

Published
2024
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30. Impact of combined tranexamic acid and vancomycin treatment on osteogenic differentiated human bone marrow-derived mesenchymal stromal cells (hBMSCs) in vitro

Author

Weißenberger, Manuel, primary, Wagenbrenner, Mike, additional, Heinz, Tizian, additional, Jakuscheit, Axel, additional, Horas, Konstantin, additional, Docheva, Denitsa, additional, Rudert, Maximilian, additional, Mayer-Wagner, Susanne, additional, Holzapfel, Boris M., additional, and Arnholdt, Jörg, additional

Published
2024
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33. Functionalization of Titanium Surfaces Using Laser Ablation in Vacuum and Liquid by Hydrolytically Instable Casi2 Affects Behavior of Bone Healing-Related Cell Types

Author

Křenek, Tomáš, primary, Pola, Josef, additional, Stich, Theresia, additional, Pattappa, Girish, additional, Docheva, Denitsa, additional, Koštejn, Martin, additional, Medlín, Rostislav, additional, Mikysek, Petr, additional, Jandová, Věra, additional, Pola, Michal, additional, Kovářík, Tomáš, additional, Cassel, Júlia, additional, Holzman, Martin, additional, and Moskal, Denys, additional

Published
2024
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38. Sclerostin modulates the degree of mineralization and the stiffness profile of the fibrocartilaginous enthesis for mechanical tissue integrity

Author

Yambe, Shinsei, primary, Yoshimoto, Yuki, additional, Ikeda, Kazutaka, additional, Maki, Koichiro, additional, Takimoto, Aki, additional, Higuchi, Shinnosuke, additional, Yu, Xinyi, additional, Uchibe, Kenta, additional, Miura, Shigenori, additional, Watanabe, Hitomi, additional, Sakuma, Tetsushi, additional, Yamamoto, Takashi, additional, Tanimoto, Kotaro, additional, Kondoh, Gen, additional, Docheva, Denitsa, additional, Adachi, Taiji, additional, and Shukunami, Chisa, additional

Published
2023
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40. Bone regeneration after marginal bone resection in two-stage treatment of chronic long bone infection - a combined histopathological and clinical pilot study

Author

Wang, Gongteng, Alagboso, Francisca, Wagner, Nike, Baertl, Susanne, Brochhausen, Christoph, Docheva, Denitsa, Rupp, Markus, and Alt, Volker

Subjects
Bone Regeneration, Tartrate-Resistant Acid Phosphatase, 610 Medizin, Humans, Polymethyl Methacrylate, Bone infection, Osteomyelitis, Fracture-related infection, Debridement, Antibiotics, Bone, General Earth and Planetary Sciences, Pilot Projects, Anti-Bacterial Agents, General Environmental Science
Abstract

Introduction: In chronic bone infection, marginal bone resection avoids large and difficult to reconstruct bone defects. However, there is still a lack of knowledge on bone regeneration during chronic bone infection and bone healing capability after marginal bone resection. Therefore, the purpose of this study was to investigate the clinical and histopathological outcomes after marginal bone resection in chronic long bone infection. We hypothesized that there is a regenerative bone healing potential after marginal bone resection that results in an acceptable clinical outcome and improved pathohistological bone healing parameters during treatment. Materials and methods: Nine patients were treated for chronic bone infections in a two-stage manner with marginal bone resection of the infected area and the placement of an antibiotic-loaded polymethyl methacrylate (PMMA) spacer at stage one followed by bone reconstruction at stage two combined with systemic antibiotic therapy. Comparable bone samples were harvested at the border region between vital and necrotic bone area during stage one and the identical location during stage two. Control bone samples were harvested from five healthy patients without bone infection. Clinical outcome in terms of infection eradication and bone consolidation were assessed. The phenotypic changes of osteocyte and morphological changes of lacunar-canalicular network were investigated by histological and immunohistochemical staining between the two observation periods. Furthermore, expression levels of major bone formation and resorption markers were investigated by immunohistochemical and tartrate-resistant acid phosphatase (TRAP) staining. Results: The clinical results with a follow-up of 12.9 months showed that eight of nine patients (88.9%) achieved bone consolidation after a planned two-stage procedure of marginal resection of necrotic bone and consecutive reconstruction. In four of the nine patients (44.4%), additional marginal debridements after stage two had to be performed. After marginal resection at stage one, the improved bone formation ability at stage two was demonstrated by significantly lower percentage of empty lacunae, significantly more mature osteocytes and higher BMP-2 positive cell density, whereas decreased resorption was indicated by significantly lower osteoclast density and RANKL/OPG ratio. In patients requiring additional debridement compared to patients without additional debridements, a significantly higher percentage of empty lacunae was found at stage one. Conclusion: Marginal bone resection combined with local and systemic antibiotic therapy is a feasible treatment option to avoid large bone defects as bone from the marginal resection area seems to have good regenerative potential. Despite a high revision rate of 44.4%, this technique avoids large bone resection and revisions can be done by further marginal debridements.

Published
2022
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42. Dynamics of single cell femtosecond laser printing

Author

Zhang, Jun, primary, Frank, Christine, additional, Byers, Patrick, additional, Djordjevic, Sasa, additional, Docheva, Denitsa, additional, Clausen-Schaumann, Hauke, additional, Sudhop, Stefanie, additional, and Huber, Heinz P., additional

Published
2023
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