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10. Protonentherapie als Sekundärtherapie bei Lokalrezidiv uvealer Melanome

Author

Riechardt, AI, Cordini, D, Dobner, B, Seibel, I, Gundlach, E, Rehak, M, Hager, A, Stark, R, and Joussen, AM

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die meisten Methoden zur Behandlung des uvealen Melanoms weisen hohe lokale Tumorkontrollraten auf, jedoch sind Rezidive bei allen Methoden möglich. Methoden: Follow-up von insg. 48 Patienten mit PBT eines Lokalrezidives eines uvealen Melanoms, die zwischen 07/00 und 12/10[for full text, please go to the a.m. URL], 65. Tagung der Vereinigung Norddeutscher Augenärzte

Published
2015
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30. Morphology and structures in double-, triple- and quadruple-chain phospholipid monolayers at the air/water interface.

Author

Kremer, F., Lagaly, G., Appell, J., Porte, G., Brezesinski, G., Dietrich, A., Dobner, B., and Möhwald, H.

Abstract

The structure of double-, triple- and quadruple-chain phospholipid monolayers has been studied by Synchrotron x-ray diffraction. The double-chain mixed-linkage species exhibit an oblique structure at all pressures investigated. The triple-chain phospholipids show at lower lateral pressures a rectangular unit cell with a phase transition at higher pressures to a hexagonal packing of vertically arranged chains. The quadruple-chain lipid exhibits only the hexagonal phase structure. The position of the ether linkage and of the branched chain on the glycerol backbone has also a strong influence on the monolayer structures. Fluorescence microscopy shows different domain shapes for the different molecules investigated. The anisotropy of the domain shapes seems to be connected with the anisotropy of the structure. Obviously, the compound with the larger lattice anisotropy (larger chain tilt) exhibits dendritic domains. [ABSTRACT FROM AUTHOR]

Published
1995
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36. Stability and Structures of Liquid Crystalline Phases Formed by Branched-Chain Phospholipid Diastereomers

Author

Bringezu, F., Rapp, G., Dobner, B., Nuhn, P., and Brezesinski, G.

Abstract

Diastereomers of 1-alkyl-2-acylglycerophosphocholines containing 2-methyl-branched fatty acids at the C2 position of the glycerol are synthesized and separated, varying the acyl-chain systematically (m = 13, 15, 17). The physicochemical properties are studied in monolayers at the air−water interface by pressure area isotherms and grazing incidence X-ray diffraction (GIXD) measurements. The phase behavior is examined by a combination of differential scanning calorimetry and time-resolved X-ray diffraction experiments. In monolayers at the air−water interface, the introduction of a methyl-branch disturbs the lateral packing drastically, resulting in phases with strongly tilted chains and an undefined tilt azimuth. The monolayer structures of the diastereomeric fractions cannot be distinguished. The comparison of the lyotropic mesophases of the aqueous dispersions shows comparable structural parameters. The temperature dependency of the d spacings is nonlinear and is discussed in terms of a critical swelling of the bilayer. The present experiments show that the two racemic pairs of the resolved diastereomers (SS + RR/SR + RS) exhibit pronounced differences in the thermodynamic parameters of phase transitions both in two-dimensional (monolayers at the air/water interface) and three-dimensional systems (aqueous dispersions). However, the influence of the chiral carbon atoms is not sufficient to change the structure of the phases despite being able to affect their stability.

Published
2001

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