1. The intersection between host-pathogen interactions and metabolism during Vibrio cholerae infection.
- Author
-
Dominguez SR, Doan PN, and Rivera-Chávez F
- Subjects
- Child, Humans, Cholera Toxin metabolism, Host-Pathogen Interactions, Cholera, Vibrio cholerae metabolism, Bacteriophages metabolism
- Abstract
Vibrio cholerae (V. cholerae), the etiological agent of cholera, uses cholera toxin (CT) to cause severe diarrheal disease. Cholera is still a significant cause of mortality worldwide with about half of all cholera cases and deaths occurring in children under five. Owing to the lack of cost-effective vaccination and poor vaccine efficacy in children, there is a need for alternative preventative and therapeutic strategies. Recent advances in our knowledge of the interplay between CT-induced disease and host-pathogen metabolism have opened the door for investigating how modulation of intestinal metabolism by V. cholerae during disease impacts host intestinal immunity, the gut microbiota, and pathogen-phage interactions. In this review article, we examine recent progress in our understanding of host-pathogen interactions during V. cholerae infection and discuss future work deciphering how modulation of gut metabolism during cholera intersects these processes to enable successful fecal-oral transmission of the pathogen., Competing Interests: Declaration of Competing Interest The authors declare no competing interests., (Published by Elsevier Ltd.)
- Published
- 2024
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