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Your search keyword '"Do Carmo, Flavia Almada"' showing total 17 results
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17 results on '"Do Carmo, Flavia Almada"'

8. Development of SEDDS formulation containing caffeine for dermal delivery

Author

de Almeida, Igor de Andrade Assunção, primary, Honório, Thiago da Silva, additional, do Carmo, Flavia Almada, additional, de Freitas, Zaida Maria Faria, additional, Simon, Alice, additional, Rangel Rodrigues, Carlos, additional, Pereira de Sousa, Valeria, additional, Cabral, Lucio Mendes, additional, and de Abreu, Letícia Coli Louvisse, additional

Published
2023
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12. Nanoparticles Loaded with a New Thiourea Derivative: Development and In vitro Evaluation Against Leishmania amazonensis

Author

Meireles, Paloma Wetler, primary, de Souza, Dandara Paiva Barroso, additional, Rezende, Marianne Grilo, additional, Borsodi, Maria Paula Gonçalves, additional, de Oliveira, Douglas Escrivani, additional, da Silva, Luiz Cláudio Rodrigues Pereira, additional, de Souza, Alessandra Mendonça Teles, additional, Viana, Gil Mendes, additional, Rodrigues, Carlos Rangel, additional, do Carmo, Flavia Almada, additional, de Sousa, Valeria Pereira, additional, Rossi-Bergmann, Bartira, additional, and Cabral, Lucio Mendes, additional

Published
2020
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13. Vancomycin-loaded nanoparticles against vancomycin intermediate and methicillin resistant Staphylococcus aureus strains

Author

Simon, Alice, primary, Moreira, Marina Lucianeli Araujo, additional, Costa, Isabela Francisca de Jesus Borges, additional, de Sousa, Valeria Pereira, additional, Rodrigues, Carlos Rangel, additional, da Rocha e Lima, Luís Maurício Trambaioli, additional, Sisnande, Tháyna, additional, do Carmo, Flavia Almada, additional, Leal, Ivana Correa Ramos, additional, dos Santos, Katia Regina Netto, additional, da Silva, Luiz Claudio Rodrigues Pereira, additional, and Cabral, Lucio Mendes, additional

Published
2020
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14. Full-factorial design for statistical planning of attritor milling parameters and evaluation of effects on particle size and structure of sodium-montmorillonite

Author

Villaça, Jaqueline C, primary, da Silva, Luiz Cláudio R P, additional, Locatelli, Fernanda R, additional, Meireles, Paloma W, additional, do Carmo, Flavia Almada, additional, Rodrigues, Carlos R, additional, Tavares, Maria Inês B, additional, de Sousa, Valeria P, additional, and Cabral, Lucio M, additional

Published
2020
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15. Nanoparticles Loaded with a New Thiourea Derivative: Development and In vitroEvaluation Against Leishmania amazonensis

Author

Meireles, Paloma Wetler, de Souza, Dandara Paiva Barroso, Rezende, Marianne Grilo, Borsodi, Maria Paula Gonçalves, de Oliveira, Douglas Escrivani, da Silva, Luiz Cláudio Rodrigues Pereira, de Souza, Alessandra Mendonça Teles, Viana, Gil Mendes, Rodrigues, Carlos Rangel, do Carmo, Flavia Almada, de Sousa, Valeria Pereira, Rossi-Bergmann, Bartira, and Cabral, Lucio Mendes

Abstract

Background: Leishmaniasis is a neglected tropical disease caused by protozoa of the genus Leishmania. Current treatments are restricted to a small number of drugs that display both severe side effects and a potential for parasites to develop resistance. A new N-(3,4-methylenedioxyphenyl)-N'- (2-phenethyl) thiourea compound (thiourea 1) has shown promising in vitro activity against Leishmania amazonensis with an IC50 of 54.14 μM for promastigotes and an IC50 of 70 μM for amastigotes. Objective: To develop a formulation of thiourea 1 as an oral treatment for leishmaniasis, it was incorporated into Nanoparticles (NPs), a proven approach to provide long-acting drug delivery systems. Methods: Poly (D,L-Lactic-co-Glycolic Acid) (PLGA) polymeric NPs containing thiourea 1 were obtained through a nanoprecipitation methodology associated with solvent evaporation. The NPs containing thiourea 1 were characterized for Encapsulation Efficiency (EE%), reaction yield (% w/w), surface charge, particle size and morphology by Transmission Electron Microscopy (TEM). Results: NPs with thiourea 1 showed an improved in vitro leishmanicidal activity with a reduction in its cytotoxicity against macrophages (CC50>100 μg/mL) while preserving its IC50 against intracellular amastigotes (1.46 ± 0.09 μg/mL). This represents a parasite Selectivity Index (SI) of 68.49, which is a marked advancement from the reference drug pentamidine (SI = 30.14). Conclusion: The results suggest that the incorporation into NPs potentiated the therapeutic effect of thiourea 1, most likely by improving the selective delivery of the drug to the phagocytic cells that are targeted for infection by L. amazonensis. This work reinforces the importance of nanotechnology in the acquisition of new therapeutic alternatives for oral treatments.

Published
2020
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16. The Preparation and Evaluation of Sodium and Alkylammonium Montmorillonite and Polysaccharide Nanocomposites as Sustained Release Excipients.

Author

Rocha, Helvécio V. A., Gomes, Ailton S., Dornelas, Camila B., Do Carmo, Flavia Almada, Rodrigues, Carlos R., Castro, Helena, Dos Santos, Tereza C., and Cabral, Lucio M.

Subjects
BIOMEDICAL materials, SURFACE coatings, ETHYLCELLULOSE, MONTMORILLONITE, NANOTECHNOLOGY, POLYSACCHARIDES
Abstract

Nanotechnology has contributed to the creation of several products and industrial methods. Herein we tested the intercalation of biomaterials into inorganic nanolamellae as pharmaceutical excipients. These materials included sodium and alkylammonium montmorillonite, viscogel B8, ethylcellulose, and chitosan, and the intercalation results success was observed with ethylcellulose and viscogel B8. Thus this nanocomposite was tested with dapsone pills as a model in simulated gastric and enteral fluids and showed a close zero order type kinetics and a higher drug release retardation. This data suggests that this nanocomposite has potential not only for colon specific use but also for prolonged release systems coatings. [ABSTRACT FROM AUTHOR]

Published
2008
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17. Preparation and evaluation of lidocaine hydrochloride in cyclodextrin inclusion complexes for development of stable gel in association with chlorhexidine gluconate for urogenital use.

Author

Soares da Silva LF, do Carmo FA, de Almeida Borges VR, Monteiro LM, Rodrigues CR, Cabral LM, and de Sousa VP

Subjects
Analysis of Variance, Chlorhexidine chemistry, Chlorhexidine pharmacokinetics, Chromatography, High Pressure Liquid, Drug Stability, Elastic Modulus, Lidocaine pharmacokinetics, Linear Models, Models, Biological, Reproducibility of Results, Vaginal Creams, Foams, and Jellies chemistry, Viscosity, Chlorhexidine analogs & derivatives, Cyclodextrins chemistry, Gels chemistry, Lidocaine chemistry
Abstract

Inclusions of lidocaine hydrochloride in cyclodextrins were prepared to obtain stable complexes compatible for association with chlorhexidine in a new gel formulation for use in urogenital applications. Two cyclodextrins, β-cyclodextrin and methyl-β-cyclodextrin, were used for encapsulating lidocaine hydrochloride through solubilization and kneading techniques. The lidocaine-cyclodextrin complexes were characterized by ultraviolet spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction. The results revealed that the techniques generated good yields of inclusion products that maintained the functional properties of lidocaine. In addition, the inclusion products obtained improved the compatibility of lidocaine hydrochloride with chlorhexidine in solution and a gel formulation. The gel formulation displayed desirable rheological and physicochemical properties. The results presented here are the first description of the inclusion of lidocaine with cyclodextrins, which improves compatibility with chlorhexidine in formulations for simultaneous delivery.

Published
2011
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