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Despite the identification of several dozen genetic loci associated with ischemic stroke (IS), the genetic bases of this disease remain largely unexplored. In this research we present the results of genome-wide association studies (GWAS) based on classical statistical testing and machine learning algorithms (logistic regression, gradient boosting on decision trees, and tabular deep learning model TabNet). To build a consensus on the results obtained by different techniques, the Pareto-Optimal solution was proposed and applied. These methods were applied to real genotypic data of sick and healthy individuals of European ancestry obtained from the Database of Genotypes and Phenotypes (5,581 individuals, 883,749 single nucleotide polymorphisms). Finally, 131 genes were identified as candidates for association with the onset of IS. UBQLN1, TRPS1, and MUSK were previously described as associated with the course of IS in model animals. ACOT11 taking part in metabolism of fatty acids was shown for the first time to be associated with IS. The identified genes were compared with genes from the Illuminating Druggable Genome project. The product of GPR26 representing the G-coupled protein receptor can be considered as a therapeutic target for stroke prevention. The approaches presented in this research can be used to reprocess GWAS datasets from other diseases.

Identification of infrastructure and human damage assessment tweets is beneficial to disaster management organizations as well as victims during a disaster. Most of the prior works focused on the detection of informative/situational tweets, and infrastructure damage, only one focused on human damage. This study presents a novel approach for detecting damage assessment tweets involving infrastructure and human damages. We investigated the potential of the Bidirectional Encoder Representations from Transformer (BERT) model to learn universal contextualized representations targeting to demonstrate its effectiveness for binary and multi-class classification of disaster damage assessment tweets. The objective is to exploit a pre-trained BERT as a transfer learning mechanism after fine-tuning important hyper-parameters on the CrisisMMD dataset containing seven disasters. The effectiveness of fine-tuned BERT is compared with five benchmarks and nine comparable models by conducting exhaustive experiments. The findings show that the fine-tuned BERT outperformed all benchmarks and comparable models and achieved state-of-the-art performance by demonstrating up to 95.12% macro-f1-score, and 88% macro-f1-score for binary and multi-class classification. Specifically, the improvement in the classification of human damage is promising.

Hope Speech Detection (HSD) from social media is a new direction for promoting and supporting positive content to encourage harmony and positivity in society. As users of social media belong to different linguistic communities, hope speech detection is rarely studied as a multilingual task considering low-resource languages. Moreover, prior studies explored only monolingual techniques, and the Russian language is not addressed. This study tackles the issue of Multi-lingual Hope Speech Detection (MHSD) in English and Russian languages using the transfer learning paradigm with fine-tuning approach. We explore joint multi-lingual and translation-based approaches to tackle the task of multilingualism, where the latter approach adopts the translation mechanism to transform all content into one language and then classify them. The joint multi-lingual method handles it by designing a universal classifier for various languages. We explore the strengths of the Robustly Optimized BERT Pre-Training Approach (RoBERTa) that showed a benchmark in capturing the semantics and contextual information within the content. The proposed framework consists of several stages: 1) data preprocessing, 2) representation of data using RoBERTa models, 3) fine-tuning phase, and 4) classification of hope speech into two labels. A new Russian corpus for hope speech detection is built, containing YouTube comments. Several experiments are conducted in English and Russian languages by using semi-supervised bilingual English and Russian datasets. The findings show that the proposed framework demonstrated benchmark performance and outperformed the baselines. Furthermore, the translation-based approach (Russian-RoBERTa) offered the best performance by achieving 94% accuracy and 80.24% f1-score.

Identification of threatening text on social media platforms is a challenging task. Contrary to the high-resource languages, the Urdu language has very limited such approaches and the benchmark approach has an issue of inappropriate data annotation. Therefore, we present robust threatening content and target identification as a hierarchical classification model for Urdu tweets. This study investigates the potential of the Urdu-BERT (Bidirectional Encoder Representations from Transformer) language model to learn universal contextualized representations aiming to showcase its usefulness for binary classification tasks of threatening content and target identification. We propose to exploit a pre-trained Urdu-BERT as a transfer learning model after fine-tuning its parameters on a newly designed Urdu corpus from the Twitter platform. The proposed dataset contains 2,400 tweets manually annotated as threatening or non-threatening at the first level and threatening tweets are further categorized into individual or group at the second level. The performance of fine-tuned Urdu-BERT is compared with the benchmark study and other feature models. Experimental results show that the fine-tuned Urdu-BERT model achieves state-of-the-art performance by obtaining 87.5% accuracy and 87.8% F1-score for threatening content identification and 82.5% accuracy and 83.2% F1-score for target identification task. Furthermore, the proposed model outperforms the benchmark study.

Researchers working in various domains are focusing on extracting information from data sets by data mining techniques. However, data mining is a complicated task, including multiple complex processes, so that it is unfriendly to non-computer researchers. Due to the lack of experience, they cannot design suitable workflows that lead to satisfactory results. This article proposes an ontology-based approach to help users choose appropriate data mining techniques for analyzing domain data. By merging with domain ontology and extracting the corresponding sub-ontology based on the task requirements, an ontology oriented to a specific domain is generated that can be used for algorithm selection. Users can query for suitable algorithms according to the current data characteristics and task requirements step by step. We build a workflow to analyze the Acid-Base State of patients at operative measures based on the proposed approach and obtain appropriate conclusions.