150 results on '"Dmitry A Kuznetsov"'
Search Results
2. Ultrashort ssDNA in Retinoblastoma Patients Blood Plasma Detected by a Novel High Resolution HPCL Technique: a Preliminary Report
- Author
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Kirill V. Ermakov, Alexander A. Bukhvostov, Alexander S. Vedenkin, Sergey V. Stovbun, Anton S. Dvornikov, and Dmitry A. Kuznetsov
- Subjects
retinoblastoma ,blood plasma ,cfdna ,ssdna ,hplc ,Medicine - Abstract
A significant population of ultrashort (50–150n) single-stranded DNA fragments were found in exosome-free blood plasma of retinoblastoma patients (6.84 ng mL−1), but not in plasma of healthy donors. An original high resolution HPLC technique has been proposed to reveal and characterize this peculiarity. To solve this task, a novel molecular size exclusion – anion exchange analytical technique was developed. Its applicability to diagnostics and oncogenesis research is quizzed here.
- Published
- 2020
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3. Perioperative anesthesia in children with oncological diseases: prospective single-center continuous cohort study of a 6-year clinical experience
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Nune V. Matinyan, Dmitry A. Kuznetsov, Ekaterina A. Kovaleva, Anastasia A. Tsintsadze, Ekaterina I. Belousova, Vasilii P. Akimov, and Anastasia I. Maslova
- Abstract
BACKGROUND: Effective anesthesia is one of the most important factors in rapid and successful rehabilitation after surgery. Inadequately selected analgesia and consequent pain significantly slow down the recovery process and are associated with several complications that cover almost all organs and systems and reduce the patients quality of life in the long term. OBJECTIVE: This study aimed to analyze 6 years of clinical experience with perioperative epidural anesthesia in the Research Institute of Pediatric Oncology, considering the effectiveness, safety, and satisfaction of patients and their legal representatives with this medical aid. MATERIALS AND METHODS: A prospective single-center continuous cohort study was conducted on patients who received epidural analgesia as part of perioperative anesthesia in the period from 2016 to 2021. Data from 702 (48.5%) boys and 745 (51.5%) girls were analyzed. Children were divided into three main groups according to age: from 1 month to 1 year (14.3%), from 1 year to 7 years (37.8%), and from 8 years to 18 years (47.8%). The area of surgical intervention was also considered: abdominal surgery (65.2%), thoracic (8.5%), and orthopedic (26.4%). The choice of the local anesthesia level has also influenced the results. The main study outcomes were the intensity of postoperative pain syndrome in pediatric oncosurgery and additional consumption of narcotic analgesics after the administration of a mixture of topical drugs with or without adjuvants into the epidural space. RESULTS: The effectiveness of epidural anesthesia in the intraoperative period was quite high, which is confirmed by the stability of hemodynamic parameters. Intraoperatively, additional administration of systemic narcotic analgesics was noted in 5% of the total sample. In all observed patients, epidural adjuvants (morphine and promedol) ensured the optimal duration of action and analgesic efficacy of caudal blockade in the postoperative period; therefore, additional painkillers were not needed. Satisfaction with the intervention was generally high, with 98% providing a rating of very good or good. CONCLUSION: Anesthesia methods (epidural blockade), optimal pain control, and active postoperative recovery (including early oral nutrition and mobilization) in fast-track surgery reduce stress reactions and organ dysfunction, significantly reducing the time required for a full recovery.
- Published
- 2023
4. Anti-cancer activity of ultra-short single-stranded polydeoxyribonucleotides
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Alexander S. Vedenkin, Sergey V. Stovbun, Alexander A Bukhvostov, Dmitry V. Zlenko, Ivan S. Stovbun, Vladimir N. Silnikov, Valentin V. Fursov, and Dmitry A. Kuznetsov
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Pharmacology ,Oncology ,Pharmacology (medical) - Published
- 2023
5. OCCLUDED GASES EFFECT ON ACOUSTIC EMISSION UNDER CRYSTAL SALVATION
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Dmitry M. Kuznetsov, Petr N. Kozachenko, and Olga O. Barannikova
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acoustic waves ,crystallisation ,salvation ,occluded gases. ,Mechanics of engineering. Applied mechanics ,TA349-359 - Abstract
The acoustic emission following the salt solution processes is investigated. It is educed that the acoustic emission parameters depend on the substance chemistry. It is stated that irrespective of the crystal purity degree with their dissolution the total count of signals increases logarithmically, and activity of the acoustic emission decreases exponentially. It is shown that the occluded gases liberation is a crucial element of the acoustic emission under the crystal dissolution.
- Published
- 2018
6. ON METROLOGICAL EVALUATION OF ACOUSTIC EMISSION METHOD AS TOOL OF POROUS MATERIALS IMPREGNATION CONTROL
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Vladimir L. Gaponov, Dmitry M. Kuznetsov, Ekaterina S. Cherunova, and Maria S. Zakharova
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acoustic emission ,impregnation process ,woven fabric ,amplitude of signals ,total emission. ,Mechanics of engineering. Applied mechanics ,TA349-359 - Abstract
The possibility of using the acoustic emission (AE) method to stud y the impregnation processes of the woven fabric is considered. In particular, it is found that the total AE curve irrespective of the sample size ca n be depicted by the general equation. The relaxation response time for the woven fabric is deduced from ex periments.
- Published
- 2018
7. INVESTIGATING IMPREGNATION BY ACOUSTIC EMISSION METHOD
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Vladimir L. Gaponov, Dmitry M. Kuznetsov, Ekaterina S. Cherunova, and Olga O. Barannikova
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acoustic emission ,impregnation of materials ,liquid degassing ,nondestructive control method. ,Mechanics of engineering. Applied mechanics ,TA349-359 - Abstract
The possibility of applying the acoustic emission method to studying the impregnation of various materials with liquid has been investigated. It is shown that in the process of liquid outgassing while impregnating hard materials, several different acoustic-emission patterns are identified. This indicates complexity and multistage character of the impregnation process. The data obtained permit to forecast the sphere of the AE method application as a nondestructive technique of depth and dip fullness control.
- Published
- 2018
8. Retinoblastoma: Magnetic Isotope Effects Might Make a Difference in the Current Anti-Cancer Research Strategy
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Alexander A. Bukhvostov, Anton S. Dvornikov, Kirill V. Ermakov, Pavel B. Kurapov, and Dmitry A. Kuznetsov
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retinoblastoma ,magnetic isotope effects (MIE) ,DNA repair ,Medicine - Abstract
Human retinoblastoma cells were proven to possess some very unusual DNApolβ species. Being 23.5 kDa monomers, which itself is not common for the DNApolβ superfamily members, these chromatin associated proteins manifests most of the DNApolβ-specifc functional peculiarities making them legitimate targets for DNA repair cytostatic inhibitors. Particularly, these tumor specific enzymes were found to be very sensitive to 25Mg2+-, 43Ca2+- and 67Zn2+-promoted magnetic isotope effects (MIE) caused a marked DNA sequence growth limitation as well as a formation of the size-invalid, i.e. too short in length, DNA fragments, totally inappropriate for the DNA repair purpose. This MIE-DNApolβ match may serve a starting point for further move towards the paramagnetic path in current developments of anti-cancer strategies.
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- 2017
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9. Author Correction: Magnetic field and nuclear spin influence on the DNA synthesis rate
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Sergey V. Stovbun, Dmitry V. Zlenko, Alexander A. Bukhvostov, Alexander S. Vedenkin, Alexey A. Skoblin, Dmitry A. Kuznetsov, and Anatoly L. Buchachenko
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Multidisciplinary - Published
- 2023
10. Changing trend of peasant behavior in Russia during Stolypin's agrarian reform
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Dmitry V. Kuznetsov
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General Medicine ,General Chemistry - Abstract
In this article, the authors aim to differentiate various categories of the peasantry according to the views on property to develop an optimal research approach that will allow for an objective and comprehensive analysis of the attitudes and behavior of the peasant population of Russia during the Stolypin course of agrarian policy pursued by the autocracy. The study shows the validity of using the peasantry's attitude to property as one of the key criteria for assessing the degree of efficiency of the Stolypin reform. The selected criterion allows one to show the evolution of this attitude depending on the social characteristics of a particular category of peasants. Any reform should be assessed from the standpoint of those whose interests are affected first. Property is one of the main guidelines that determine the position of a person in society and the world. Aimed at creating the stratum of steady owners in the village, P.A. Stolypin's reform frees the peasants from the petty fiscal and bureaucratic oversight of the state. As the peasantry realizes the seriousness of the government's intentions and possible prospects for the development of the economy, their attitude to the reform also changes. This change takes place along with the peasantry's realization that the state is interested in steady owners in the village. Those who can and want to be one, accept the reform with enthusiasm, others ultimately see in the reform an opportunity to shift the blame for their failure to the state.
- Published
- 2023
11. COASTAL DYNAMICS OF THE PECHORA AND KARA SEAS UNDER CHANGING CLIMATIC CONDITIONS AND HUMAN DISTURBANCES
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Stanislav A. Ogorodov, Alisa V. Baranskaya, Nataliya G. Belova, Anatoly M. Kamalov, Dmitry E. Kuznetsov, Paul P. Overduin, Natalya N. Shabanova, and Aleksey P. Vergun
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coastal dynamics ,cryolithozone ,thermoabrasion ,monitoring ,multitemporal imagery ,climate change ,ice extent ,wave energy ,human impact ,pechora and kara seas ,Geography (General) ,G1-922 - Abstract
Coastal dynamics monitoring on the key areas of oil and gas development at the Barents and Kara Seas has been carried out by Laboratory of Geoecology of the North at the Faculty of Geography (Lomonosov Moscow State University) together with Zubov State Oceanographic Institute (Russian Federal Service for Hydrometeorology and Environmental Monitoring) for more than 30 years. During this period, an up-to-date monitoring technology, which includes direct field observations, remote sensing and numerical methods, has been developed. The results of such investigations are analyzed on the example of the Ural coast of Baydaratskaya Bay, Kara Sea. The dynamics of thermal-abrasion coasts are directly linked with climate and sea ice extent change. A description of how the wind-wave energy flux and the duration of the ice-free period affect the coastal line retreat is provided, along with a method of the wind-wave energy assessment and its results for the Kara Sea region. We have also evaluated the influence of local anthropogenic impacts on the dynamics of the Arctic coasts. As a result, methods of investigations necessary for obtaining the parameters required for the forecast of the retreat of thermoabrasional coasts have been developed.
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- 2016
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12. Monitoring technique for catalytic waste treatment by acoustic emission parameters
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Vladimir L. Gaponov and Dmitry M. Kuznetsov
- Subjects
каталитическая очистка ,пероксид водорода ,катализатор ,разложение пероксида водорода ,перманганатометрический способ ,метод акустической эмиссии ,catalytic treatment ,hydrogen peroxide ,catalyst ,decomposition of hydrogen peroxide ,permanganatometric method ,method of acoustic emission ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
The work objective is to study issues of determining the hydrogen peroxide concentration. The task is to evaluate metrological aspects of the hydrogen peroxide decomposition. Alongside with a standard permanganatometric (analytical) method of determining the hydrogen peroxide concentration, a fairly new technique of the acoustic emission is considered. A new methodology of the problem solution developed by the authors is presented. The study has found that the hydrogen peroxide catalytic decomposition reaction is characterized by a strongly marked transient process at the initial stage. Further, the total number of pulses uniformly increases, and then the hydrogen peroxide concentration gradually decreases. The proposed method of monitoring the acoustic emission parameters shows high informativity and sensitivity. It is found that the spread in the experimental values obtained by the two methods is identical - 5 - 6% of the measured value.
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- 2016
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13. Metrological aspects of acoustic emission conditions under hydrogen peroxide decomposition monitoring
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Vladimir L. Gaponov, Dmitry M. Kuznetsov, and Maria S. Zakharova
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акустическая эмиссия ,химические реакции в жидкости ,пероксид водорода ,метрологическая оценка ,суммарный счет акустических сигналов ,систематические и случайные погрешности ,acoustic emission ,chemical reactions in liquid ,hydrogen peroxide ,metrological evaluation ,total count of acoustic signals ,systematic and random errors ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
The work objective is to study the metrological aspects of the acoustic emission (AE) method as applied to the monitoring of the hydrogen peroxide decay rate. The AE changing parameter that determines the method metrological properties as a whole is selected. It is established that the process of the hydrogen peroxide decomposition causes stress waves in the local liquid volume. This leads to the formation of the acoustic signals that allow firmly control this process through the AE method. The metrological evaluation of the method implemented in two stages is analyzed. The significance of the first stage allowing for the quality relative AE-research is identified. The experiments performed have confirmed high sensitivity of the proposed method. Thus, it is possible to carry out effective relative studies of the compared processes according to the AE parameters. The acoustic emission data show that instrumental and methodological errors of the AE method in general can be significant in case of the counter conditions, and this fact can be a benchmark for future research.
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- 2016
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14. «Revolutionary opera»: history and modernity
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Dmitry V. Kuznetsov
- Published
- 2022
15. The Sakhalyan Operation
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Dmitry V. Kuznetsov
- Published
- 2022
16. Magnetic field and nuclear spin influence on the DNA synthesis rate
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Sergey V. Stovbun, Dmitry V. Zlenko, Alexander A. Bukhvostov, Alexander S. Vedenkin, Alexey A. Skoblin, Dmitry A. Kuznetsov, and Anatoly L. Buchachenko
- Subjects
Multidisciplinary - Abstract
The rate of a chemical reaction can be sensitive to the isotope composition of the reactants, which provides also for the sensitivity of such “spin-sensitive” reactions to the external magnetic field. Here we demonstrate the effect of the external magnetic field on the enzymatic DNA synthesis together with the effect of the spin-bearing magnesium ions ($$^{25}$$ 25 Mg). The rate of DNA synthesis monotonously decreased with the external magnetic field induction increasing in presence of zero-spin magnesium ions ($$^{24}$$ 24 Mg). On the contrary, in the presence of the spin-bearing magnesium ions, the dependence of the reaction rate on the magnetic field induction was non-monotonous and possess a distinct minimum at 80–100 mT. To describe the observed effect, we suggested a chemical scheme and biophysical mechanism considering a competition between Zeeman and Fermi interactions in the external magnetic field.
- Published
- 2023
17. PSYCHOLOGICAL AND PEDAGOGICAL FACILITATION AS A NECESSARY CONDITION OF SUCCESSFUL SELF-DETERMINATION OF HIGHER SCHOOL STUDENTS
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Dmitry V. Kuznetsov
- Subjects
самоопределение старшеклассников ,личностно ориентированное обучение ,психолого-педагогическая фасилитация ,средства фасилитации ,Education - Abstract
The purpose of the study is to identify possible psychological and educational facilitation ways among high school students to get their values shaped in the framework of self-determination.Methods. The analysis and generalization of the Russian and foreign sources on methodology, theory and practice of psychological and pedagogical facilitation are used in the present study. The technique of valuable orientations by M. Rokich is involved in psychological and pedagogical experiment. Essays, discussions, consultations, non-directive trainings, methods of value orientations are used as means of facilitation.Results. The need of psychological and pedagogical process maintenance of personality formation of youthful age is proved; it is based on humanistic approach and idea of the facilitation which was proposed by K. Rogers as opposed to authoritative, directive methods of influence. The data show a positive impact of facilitation on the formation of self-determination process at high school age: the individual values structure has become relatively stable, characterized by a more active position in relation to the world and students’ future. Scientific novelty. The concept of psycho-pedagogical facilitation in relation to the issue of self-determination of high school pupils is clarified. It is suggested that there is a direct link between psychological/educational support and mental processes, which is confirmed by statistically significant results in the values hierarchy survey of senior students.Practical significance. The research findings can be used while designing special programs as for educational organizations and supplementary education.
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- 2015
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18. Ultrasound navigation during retrobulbar blockade in children with retinoblastoma and enucleation of the eyeball
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Ekaterina I. Belousova, Nune V. Matinyan, Anastasia A. Tsintsadze, Leonid A. Martynov, Dmitry A. Kuznetsov, Ekaterina A. Kovaleva, Tatyana L. Ushakova, and Vladimir G. Polyakov
- Abstract
BACKGROUND: The retrobulbar block in children is used to enucleate analgesia in the intra- and postoperative period and prevent oculocardiac reflex (OCD), postoperative nausea, and vomiting. However, when the block is performed blindly, it results in serious complications. AIM: This study aimed to evaluate the efficacy and safety of a retrobulbar block performed under ultrasound guidance compared with a retrobulbar block performed blindly during enucleation of the eyeball in children with retinoblastoma. MATERIALS AND METHODS: A prospective randomized controlled trial was performed. The study included 40 patients who met the inclusion criteria. The patients were divided into two groups: 20 patients who underwent ultrasound-guided retrobulbar blockade (RBВ + ultrasound) and 20 patients who underwent blindly retrobulbar blockade (RBВ). RESULTS: There was an insignificant decrease in intraoperative opioid requirements in the RBB + ultrasound group, where the average dose of fentanyl was 41.4 g/kg, and in the RBB group, 4.70.8 g/kg (p 0.05). The time before the administration of the first dose of analgesic in the postoperative period was 4.70.8 h in the RBB group and 11.73.3 h in the RBB + ultrasound group (p 0.05). VAS and CHIPPS scores obtained 6 h after the end of surgery in the RBB + ultrasound and RBB groups were 1.8 (1.2; 2) and 2.5 (3.8; 4.5) points (p 0.05), respectively. CONCLUSION: There was no statistically significant difference between the time of the retrobulbar blockade under ultrasound guidance and the retrobulbar regional block performed blindly. Retrobulbar blockade performed under ultrasound guidance provides a decrease in intraoperative opioid requirements, stable intraoperative hemodynamics, and longer postoperative analgesia.
- Published
- 2021
19. Maximising the Value of Twin Studies in Health and Behaviour
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Fiona A. Hagenbeek, Jana S. Hirzinger, Sophie Breunig, Susanne Bruins, Dmitry V. Kuznetsov, Kirsten Schut, Veronika V. Odintsova, and Dorret Boomsma
- Abstract
In the classical twin design, researchers compare trait resemblance in cohorts of identical and non-identical twins to understand how genetic and environmental factors correlate with resemblance in behaviour and other phenotypes. The twin design is also a valuable tool for studying causality, intergenerational transmission, gene-environment correlation and interaction. Here we review recent developments in twin studies, recent results from twin studies of new phenotypes, and recent insights into twinning. We ask whether the results of existing twin studies are representative of the general population and of global diversity, and conclude that stronger efforts to increase representativeness are needed. We provide an updated overview of twin concordance and discordance for major diseases and mental disorders, which conveys a crucial message: genetic influences are not as deterministic as many believe. This has important implications for public understanding of genetic risk prediction tools, as the accuracy of genetic predictions can never exceed identical twin concordance rates.
- Published
- 2022
20. Synthesis of Bisphenol A Based Phosphazene-Containing Epoxy Resin with Reduced Viscosity
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Vyacheslav V. Kireev, Yulya V. Bilichenko, Roman S. Borisov, Jianxin Mu, Dmitry A. Kuznetsov, Anastasiya V. Eroshenko, Sergey N. Filatov, and Igor S. Sirotin
- Subjects
epoxy resin, epoxy oligomer, phosphazene, bisphenol a, phenol ,Organic chemistry ,QD241-441 - Abstract
Phosphazene-containing epoxy oligomers (PEO) were synthesized by the interaction of hexachlorocyclotriphosphazene (HCP), phenol, and bisphenol A in a medium of excess of epichlorohydrin using potassium carbonate and hydroxide as HCl acceptors with the aim of obtaining a product with lower viscosity and higher phosphazene content. PEOs are mixtures of epoxycyclophosphazene (ECP) and a conventional organic epoxy resin based on bisphenol A in an amount controlled by the ratio of the initial mono- and diphenol. According to 31P NMR spectroscopy, pentasubstituted aryloxycyclotrophosphazene compounds predominate in the ECP composition. The relative content in the ECP radicals of mono- and diphenol was determined by the MALDI-TOF mass spectrometry method. The organic epoxy fraction, according to gas chromatograpy-mass spectrometry (GC-MS), contains 50−70 wt % diglycidyl ether of bisphenol A. PEO resins obtained in the present work have reduced viscosity when compared to other known phosphazene-containging epoxy resins while phosphazene content is still about 50 wt %. Resins with an epoxy number within 12−17 wt %, are cured by conventional curing agents to form compositions with flame-retardant properties, while other characteristics of these compositions are at the level of conventional epoxy materials.
- Published
- 2019
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21. Synthesis and dynamic mechanical properties of cross-linked multiblock poly(urethane-imide) copolymers
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G. V. Vaganov, Vladimir E. Yudin, I. A. Kobykhno, Oleg V. Tolochko, V. E. Smirnova, Elena N. Popova, E. S. Vasiliyeva, E. A. Bogdanova, Dmitry A. Kuznetsov, V. M. Svetlichniy, A. L. Didenko, A. G. Ivanov, and V. V. Kudryavtsev
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chemistry.chemical_classification ,chemistry.chemical_compound ,Thermogravimetric analysis ,Differential scanning calorimetry ,chemistry ,Diphenyl sulfone ,Polymer chemistry ,Copolymer ,General Chemistry ,Polymer ,Dynamic mechanical analysis ,Imide ,Isocyanate - Abstract
Poly(urethane-imide) copolymers (PUICs) containing reactive carboxyl groups in hard imide segment were synthesized from poly(propylene glycol) with isocyanate end groups, 1,3-bis(3′,4′-dicarboxyphenoxy)benzene dianhydride, aromatic diamines 4,4′-bis(4″-aminophenoxy)diphenyl sulfone or 4,4′-bis-(4″-aminophenoxy)biphenyl, and 3,5-diaminobenzoic acid. The PUICs were covalently cross-linked using reactions of carboxyl groups with aromatic diisocyanates and 1,2,5,6-diepoxycyclooctane. The polymers obtained were studied by thermogravimetric analysis, differential scanning calorimetry, and dynamic mechanical analysis. It was shown that the structure of the cross-linking agents influences the properties of cross-linked PUICs. Changes in the mechanical loss factor (tg δ) were analyzed vs. chemical structure of the PUICs. The maximum tg δ values of the copolymers studied are in the range of 0.3–0.4, which suggests good damping capacity of these systems.
- Published
- 2021
22. Silica coating of Fe3O4 magnetic nanoparticles with PMIDA assistance to increase the surface area and enhance peptide immobilization efficiency
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A. M. Demin, Alexander V. Mekhaev, Alexandra G. Pershina, Mikhail A. Uimin, Dmitry K. Kuznetsov, A. S. Minin, Vladimir Ya. Shur, Victor P. Krasnov, and Aleksei I. Maksimovskikh
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Peptide modification ,Materials science ,Iminodiacetic acid ,Process Chemistry and Technology ,Infrared spectroscopy ,engineering.material ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Nanomaterials ,chemistry.chemical_compound ,Dynamic light scattering ,Chemical engineering ,Coating ,chemistry ,Materials Chemistry ,Ceramics and Composites ,engineering ,Fourier transform infrared spectroscopy ,BET theory - Abstract
The high efficiency of using N-(phosphonomethyl)iminodiacetic acid (PMIDA) as a surfactant for formation of a silica coating on Fe3O4 magnetic nanoparticles (MNPs) with a large surface area has been demonstrated. The coating of PMIDA-stabilized MNPs with silica and their further APS-functionalization significantly increased the specific area (up to 203 m2 g−1) and the number of amino groups (up to 1.12 mmol/g) grafted on their surface compared to nanomaterials synthesized without preliminary SiO2-coating. The comparative study of the peptide modification efficiency, using as an example pH-low insertion peptide (pHLIP), of MNPs coated with 3-aminopropylsilane (APS) or SiO2/APS was carried out. It has been shown that silica coating of PMIDA-stabilized MNPs leads to a significant increase in the degree of immobilization of the peptide (up to 22 μmol per g of MNPs). Comprehensive characterization of the obtained materials at each stage of the synthesis was carried out using scanning electron microscopy (SEM), energy dispersive X-ray fluorescence spectroscopy (EDX), BET analysis, ATR Fourier transformed infrared spectroscopy (FTIR), termogravimetric analysis (TGA), CHN-elemental analysis, dynamic light scattering (DLS), and vibrating sample magnetometry (VSM). The proposed approach to applying SiO2-coating of MNPs can be useful for design of new materials for biomedical and chemical purposes.
- Published
- 2021
23. EXPERIMENTAL STUDY ON TEMPERATURE DEPENDENCE OF CAPILLARY FLOW IN POROUS MEDIA BY ACOUSTIC EMISSION METHOD
- Author
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Dmitry Mihailovich Kuznetsov, Vladimir Lavrentevich Gaponov, and Sergey Ivanovich Builo
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acoustic emission ,capillary liquid rise ,capillary filling dynamics ,temperature ,liquid column height. ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
For the first time, the acoustic emission (AE) method applicability to study the processes ongoing in the microporous medium under capillary pore filling with liquid is investigated. In particular, the temperature contribution to the dynamics of the porous materials impregnation is studied. The experimental results have shown that the most informative AE parameters reflecting the capillary liquid rise dynamics are the signal sum and the oscillation sum. The curve shape of the signal sum dependence on the AE amount follows the curve shape of the dynamic pattern of changing in the liquid elevation through the capillaries of the ceramic sample constructed from the experimental data. At the beginning of the capillary rise, the AE activity is significantly higher at higher temperatures. With increase of the liquid capillary rise, the process intensity decreases. The experimental data indicate that the AE parameters reflect the impregnation dynamics and kinetics under any change in the impregnation conditions, and they can be used for the remote process control.
- Published
- 2014
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24. The First Detection of Abomasal Nematode Ashworthius sidemi in Fallow Deer (Dama dama) in Russia
- Author
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Dmitry M. Kuznetsov
- Subjects
Dorsum ,Ashworthius sidemi ,Nematode ,biology ,Host (biology) ,law ,Quarantine ,Parasite hosting ,Zoology ,Juvenile ,Parasitology ,biology.organism_classification ,law.invention - Abstract
The aim of the study was to supplement the data concerning the spreading of nematode Ashworthius sidemi among wild ruminants in Russia. The samples of A. sidemi were collected from two fallow deer, which were born and raised in the game farm in Smolensk region (55° 16ʹ N–34° 29ʹ E). The affiliation of the detected nematodes as A. sidemi was made using morphological features (shape of the spicules and the dorsal ray of bursa for males, as well as the presence and shape of the neodont in the buccal cavity for males and females). The intensity of infection in 2 studied fallow deer was 7 and 19 individuals of A. sidemi. All of the specimens of A. sidemi had the features of juvenile forms. The registration of fallow deer as another one host of A. sidemi in Russia indicates a further spreading of this nematode and confirms the necessity of strengthening the control of this parasite. The finding of this nematode in non-native captive animals shows the imperfection of control in this sphere. A. sidemi could have been introduced to the game farm both with imported or with native animals due to insufficient quarantine and isolation. More wide further research would be useful in the light of control this potentially dangerous parasite.
- Published
- 2021
25. Kronos: Processor Family for High-Level Languages.
- Author
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Dmitry N. Kuznetsov, Alexey E. Nedorya, Eugene V. Tarassov, Vladimir E. Philippov, and Marina Ya Philippova
- Published
- 2006
- Full Text
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26. STUDY ON CYCLIC THERMODURABILITY OF CARBON MATERIALS
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Dmitry Mikhaylovich Kuznetsov, Vladimir Lavrentyevich Gaponov, and Sergey Ivanovich Buylo
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acoustic emission ,total scaling of acoustic signals ,cyclic thermal strength ,graphitized carbon mater ials ,glass carbon ,macrocrack formation ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
The thermodurability of glass carbon — one of the most promising carbon materials used in the production of lum inophors and semico nductor materials, optical single crystals, etc. — is investigated. The aim of this work was to study the behavior of glass carbon in the course of the thermal - cycle testing. As a diagnostic technique of the m icroflow initiation and progress, the signal re ception of acoustic emission was used. It is shown that a heavy disloc ation motion on the thermal - cycle exposure recognized in the acoustic emission signals is observed in the glass carbon samples when heated. As far as the number of impulses is higher whe n heated than on cooling of the sa mple, it implies the damage accumulation in the structure under the thermal - cyclic handling of the glass carbon sa mples. It is found that damage acc u mulation curves reflected by the acoustic emission pulses differ on the s tage of heating and cooling. It is proposed to use a total curve of the acoustic emission pulses as a potent ial destruction sign of a glass - carbon product when heated.
- Published
- 2014
- Full Text
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27. Mechanical Properties and Supramolecular Structure of Oriented Polyimide Films Filled with Carbon Nanofibers
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Elena N. Popova, Natalia Saprykina, K. A. Kolbe, Dmitry A. Kuznetsov, V. K. Lavrent’ev, V. E. Smirnova, and Vladimir E. Yudin
- Subjects
Diffraction ,Nanocomposite ,Materials science ,Polymers and Plastics ,Carbon nanofiber ,Supramolecular chemistry ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,law.invention ,law ,Materials Chemistry ,Electron microscope ,Composite material ,0210 nano-technology ,Prepolymer ,Polyimide ,Macromolecule - Abstract
The effect of carbon nanofibers introduced into the polyimide matrix on the mechanical properties of initial nanocomposite films and nanocomposite films oriented by uniaxial drawing at various stages of polyimide synthesis is studied. It is demonstrated that the storage moduli of nanocomposite films are higher compared to initial polyimide films at equal draw ratios. The self-orientation ability of the studied samples drawn at the stage of a prepolymer (poly(amic acid)) during thermal imidization is revealed, and it is shown that this ability increases upon the introduction of carbon nanofibers into the polyimide matrix. It is found that the polyimide films with the highest rigidity of macromolecules among the studied structures exhibit the highest storage moduli owing to their high self-orientation ability. Using X-ray diffraction and electron microscopy, a change in the supramolecular structure of rigid-chain polyimide films upon their orientational drawing at various stages of synthesis is investigated.
- Published
- 2021
28. Tailoring Ni and Sr2Mg0.25Ni0.75MoO6−δ Cermet Compositions for Designing the Fuel Electrodes of Solid Oxide Electrochemical Cells
- Author
-
Lubov S. Skutina, Aleksey A. Vylkov, Dmitry K. Kuznetsov, Dmitry A. Medvedev, and Vladimir Ya. Shur
- Subjects
SOFCs ,fuel electrodes ,double perovskite ,thermal expansion ,composite materials ,Technology - Abstract
The design of new electrode materials for solid oxide electrochemical cells, which are stable against redox processes as well as exhibiting carbon/sulphur tolerance and high electronic conductivity, is a matter of considerable current interest as a means of overcoming the disadvantages of traditional Ni-containing cermets. In the present work, composite materials having the general formula (1−x)Sr2Mg0.25Ni0.75MoO6−δ + xNiO (where x = 0, 15, 30, 50, 70 and 85 mol.%) were successfully prepared to be utilised in solid oxide fuel cells. A detailed investigation of the thermal, electrical, and microstructural properties of these composites, along with their phase stability in oxidising and reducing atmospheres, was carried out. While possessing low thermal expansion coefficient (TEC) values, the composites having low Ni content (15 mol.%−70 mol.%) did not satisfy the requirement of high electronic conductivity. Conversely, the 15Sr2Mg0.25Ni0.75MoO6−δ + 85NiO samples demonstrated very high electrical conductivity (489 S sm−1 at 850 °C in wet H2) due to well-developed Ni-based networks, and no deterioration of thermal properties (TEC values of 15.4 × 10−6 K−1 in air and 14.5 × 10−6 K−1 in 50%H2/Ar; linear expansion behaviour in both atmospheres). Therefore, this material has potential for use as a component of a fuel cell electrode system.
- Published
- 2019
- Full Text
- View/download PDF
29. Influence of mineral fertilizers and seeding rates on the yield and quality of spring wheat grain
- Author
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Dmitry Aleksandrovich Kuznetsov
- Subjects
Horticulture ,Wheat grain ,food and beverages ,Mathematics - Abstract
The article presents the results of field research conducted in 2018-2019 on leached Chernozem of the Volga forest-steppe. The objects of research are varieties of spring wheat-Tulaykovskaya 10, Yoldyz and Tulaykovskaya 108. At different seeding rates of 5.0 and 5.5 million germinating seeds per ha, the effect of mineral fertilizers on 1 ha was studied. They were represented by a complete mineral fertilizer (azofoska) and fertilizing with a mineral nitrogen fertilizer in the tillering phase at doses of 30, 60 and 90 kg of AD/ha against this background. Analysis of the yield of spring wheat varieties indicates that the harvest of grain variety Yoldyz in variants with a seeding rate of 5.5 million germinating seeds per ha against the background of the application of ammonium nitrate at a dose of 60 kg of DA (2.52 t/ha) was superior to other varieties Tulaykovskaya 10 and Tulaykovskaya 108 (2.51 and 2.46 t/ha). The maximum increase in seed productivity when adding ammonium nitrate in the tillage phase of the crop was in Tulaykovskaya 10 variety (0.34 t/ha), the lowest in the Yoldyz variety (0.06 t/ha) compared to the variant with amofoska application in the pre-sowing cultivation. When increasing the doses of nitrogen fertilizers there was an increase in the water content of all the studied varieties by 1-3 PCs. While increasing the seeding rate from 5.0 to 5.5 million germinating seeds per 1 ha the number of grains in the ear changed on average for varieties by 1-2 PCs. Of all the studied varieties, the largest mass of 1,000 grains was in the Yoldyz variety (40.56 g) after azofoska application in the presowing cultivation + N60 during tillering at a seeding rate of 5.0 million germinating seeds per 1 ha, the smallest in the Tulaykovskaya 108 variety (37.87 g) after azofoska application at a dose of 0.15 t/ha at a seeding rate of 5.0 million germinating seeds per 1 ha.
- Published
- 2020
30. SPECTRAL-LUMINESCENT PROPERTIES OF SOME NEW DIHYDROXY-2H-1-BENZOPYRAN-2-ONES SYNTHESIZED BASED ON 2,4,6-TRIHYDROXYTOLUENE
- Author
-
Sergey S. Bobylev, Dmitry N. Kuznetsov, and K. I. Kobrakov
- Subjects
Chemistry ,General Chemical Engineering ,Benzopyran-2-ones ,General Chemistry ,Luminescence ,Combinatorial chemistry - Abstract
2,4,6-trihydroxytoluene (methylphloroglucinol) is a promising reagent in organic synthesis, after development out getting it from 2,4,6-trinitrotoluene. We previously synthesized of derivatives of 5,7-dihydroxy-2H-1-benzopyran-2-ones by the interaction of 2,4,6-trihydroxytoluene and 2,4,6 -trihydroxy-3-methylbenzoic acid with polyfunctional carbonyl compounds. The first time, a detailed analysis of the electronic absorption and fluorescence spectra of derivatives of 5,7-dihydroxy-2H-1-benzopyran-2-ones is carried out. In the electronic absorption spectra of the studied compounds, the absorption in the long-wavelength region of the spectrum is determined by electronic transitions with intramolecular charge carry. The possibility of controlling the bathochromic or hypsochromic shift of the long-wavelength absorption band by introducing substituents of various electronic nature into the molecule has been revealed. It was shown that some of the studied compounds have pronounced luminescence in the blue-green region of the spectrum (390–508 nm) with a quantum yield of 9–40%. The highest quantum yield (38%) was achieved when the 5,7-dihydroxy-2H-1-benzopyran-2-one carboxyl group was introduced into position 6. The bromination of this compound leads to a decrease in the quantum yield to 9.5 % The introduction into the 3 position of 5,7-dihydroxy-4,8-dimethylchromen-2-one phenyl substituted fragment along with O-acylation leads to a sharp decrease in the quantum yield. It is concluded that the studied objects are promising as basic structures for the search for new biosensors.
- Published
- 2020
31. Study of the biological and antioxidant activity of (Z)-2-(hydroxybenzylidene)-4,6-dihydroxy-7-methylbenzofuran-3(2H)-ones
- Author
-
Valentina V. Martazova, K. I. Kobrakov, Dmitry N. Kuznetsov, and Dmitry A. Shubin
- Subjects
Environmental Engineering ,Antioxidant ,Chemistry ,medicine.medical_treatment ,medicine ,Medicinal chemistry ,Industrial and Manufacturing Engineering - Abstract
Studies on the discovery of the chemical potential of 2,4,6-trihydroxytoluene, which has become an affordable reagent in organic synthesis after the development at IPCET SB RAS (Institute for problems of chemical and energetic technologies of the Siberian branch оf the Russian academy of sciences) of technology for its preparation from 2,4,6-trinitrotoluene, we have been conducting systematic studies in recent years to obtain it basis of various multifunctional carbo- and heterocyclic compounds. The paper presents the results of a study of the biological and antioxidant activity of hydroxyderivatives of 2-benzylidenebenzofuran-3(2H)-ones obtained on the basis of 2,4,6-trihydroxytoluene. The compounds studied in the work showed high inhibitory activity against selected test strains (Escherichia coli, Pseudomonas fluorescens, Staphylococcus aureus, Bacillus subtilis). A study of the fungicidal activity of the synthesized compounds showed that the percentage of suppression of fungal strains (Aspergillus niger, Aspergillus flavus, Penicillium chrysogenum, Ulocladium atrum and Penicillium funiculosum) ranges from 0-20%. The antioxidant properties of the synthesized aurons were studied by cyclic voltammetry on a carbon-metal electrode. Ethanol solutions of rutin and quercetin were used as reference standards. The total antioxidant activity (∑AOA) was estimated spectrophotometrically using a liquid-phase reaction with a chromophore radical, 2,2′-diphenyl-1-picrylhydrazyl (DPPH•), according to the degree of “radical uptake” (P). It was shown that all compounds have moderate antioxidant activity, which depends mainly on the number of hydroxyl groups and their position in the compound molecule. The work shows the value of 4,6-dihydroxy-7-methylbenzofuran-3(2H)-one as a building block for combinatorial chemistry.
- Published
- 2020
32. Azo compounds based on 2-(4'-aminophenyl)-4-quinoline carboxylic acid: synthesis and properties
- Author
-
Mirzoolim H. Mavlonov, K. I. Kobrakov, and Dmitry N. Kuznetsov
- Subjects
chemistry.chemical_compound ,Environmental Engineering ,chemistry ,Quinoline ,Carboxylic acid synthesis ,Organic chemistry ,Industrial and Manufacturing Engineering - Abstract
Synthesis and studies of the properties of dyes for coloring textile materials from fibers of various chemical structures, which contain, in addition to chromophore, also pharmacophore groups in the molecule, which impart biocidal properties to both the dyes themselves and the materials dyed by them, are interesting both theoretically and from an applied point of view. The article presents data on the synthesis of a series of previously undescribed azo compounds based on 2-(4'-aminophenyl)-4-quinolinecarboxylic acid and aromatic hydroxy- and aminocompounds of the naphthalene series. Five naphthylazo derivatives of 2-(4'-aminophenyl)-4-quinolinecarboxylic acid were synthesized in high yields. The structures of the synthesized azo compounds were confirmed by mass-spectrometry and UV-spectroscopy. In the electronic absorption spectra, the absorption maximum of the synthesized azo compounds lies in the range of 480-550 nm, in contrast to the initial diazo and azo components, the absorption maxima of which lie in the near UV region of the spectrum. Dyeing techniques have been developed that provide optimal indicators for the process of coloration of polypeptide fibers (wool and nylon) with synthesized dyes. The colors of the samples have bright, and deep colors of orange-red-violet scales. The obtained painted samples were examined for color fastness to wet processing according to GOST 9733.4-83, sweat GOST 9733.6-83 and light exposure GOST 11279.2-83. It has been shown that the synthesized azo compounds can be used for coloring woolen and polyamide fibers and provide satisfactory performance properties of dyes, which is consistent with generally accepted ideas about acid dyes. Samples of dyed polyamide fabric showed satisfactory color fastness to light (1-3 points), the best result was shown by wool samples dyed with the studied dyes.
- Published
- 2020
33. Precise control of the size and gap between gold nanocubes by surface-based synthesis for high SERS performance
- Author
-
Ali Issa, Suzanna Akil, Pavel Zelenovskiy, Dmitry K. Kuznetsov, Aotmane En Naciri, Abeer Fahes, Safi Jradi, Vladimir Ya. Shur, Yann Battie, Rana Omar, Laboratoire de Chimie et Physique - Approche Multi-échelle des Milieux Complexes (LCP-A2MC), Université de Lorraine (UL), Lumière, nanomatériaux et nanotechnologies (L2n), Institut Charles Delaunay (ICD), Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS), UrFU Institute of Natural Sciences and Mathematics, and Ural Federal University [Ekaterinburg] (UrFU)
- Subjects
[PHYS]Physics [physics] ,Surface (mathematics) ,Nanocomposite ,Materials science ,Opacity ,business.industry ,Scanning electron microscope ,02 engineering and technology ,General Chemistry ,Substrate (electronics) ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,Monolayer ,Optoelectronics ,Thin film ,0210 nano-technology ,business ,Layer (electronics) - Abstract
International audience; The optical properties of a monolayer of nanocomposite film (PMMA/gold nanocubes) were provided by fitting a proposed theoretical model to spectroscopic ellipsometry (SE) measurements. For such a thin film, these features cannot be successfully determined by means of experimental and conventional effective medium theory such as Maxwell-Garnett or Bruggeman. To make it possible, we developed a model of two classical Lorentz oscillators; one for a PMMA layer and the other for GNCs, revealing one homogeneous layer and rapid analysis without the need for large computational resources. Additionally, we tailored both the size and number of GNCs in the PMMA layer by tuning the synthesis parameters as seen in scanning electron microscopy (SEM) images. In parallel, SE measurements clearly highlighted the change in the optical properties of GNCs as a function of their density on the substrate and dimensions. Our findings demonstrate that SE is an alternative method to characterize layered GNCs on opaque substrates efficiently, which has potential implications for designing other morphologies in the future.
- Published
- 2020
34. Computational and experimental method of accounting for the dewatering system in the analysis of natural frequencies and waveforms
- Author
-
Vladimir V. Gerasimchuk, Alexander V. Zhiryakov, Dmitry A. Kuznetsov, and Pyotr P. Telepnev
- Published
- 2022
35. Funding the Management of Municipal Solid Waste Through Public-Private Partnerships
- Author
-
Alexey M. Gubernatorov, Dmitry V. Kuznetsov, Irina V. Makunina, and Irina E. Bystrenina
- Published
- 2022
36. ON METROLOGICAL EVALUATION OF ACOUSTIC EMISSION METHOD AS TOOL OF POROUS MATERIALS IMPREGNATION CONTROL
- Author
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Vladimir L. Gaponov, Dmitry M. Kuznetsov, Ekaterina S. Cherunova, and Maria S. Zakharova
- Subjects
acoustic emission ,impregnation process ,woven fabric ,amplitude of signals ,total emission. ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
The possibility of using the acoustic emission (AE) method to stud y the impregnation processes of the woven fabric is considered. In particular, it is found that the total AE curve irrespective of the sample size ca n be depicted by the general equation. The relaxation response time for the woven fabric is deduced from ex periments.
- Published
- 2012
37. Synthesis of aurone derivatives on the basis of 2,4,6-trihydroxytoluene
- Author
-
Alexey M. Starosotnikov, Natal’ya L. Merkulova, K. I. Kobrakov, Dmitry N. Kuznetsov, and Dmitry A. Shubin
- Subjects
Cyperus capitatus ,chemistry.chemical_compound ,chemistry ,010405 organic chemistry ,Organic Chemistry ,Aurone ,Capitata ,Organic chemistry ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences - Abstract
2,4,6-Trihydroxytoluene (2-methylphloroglucinol) was used as starting material for the first synthesis of several (Z)-2-arylidene-4,6-dihydroxy-7-methylaurones, including a synthetic analog of the natural 7-methylaureusidin, which is currently obtained mainly from the extract of sedge capitata (Cyperus capitatus). It was shown that the reaction of 2,4,6-trihydroxytoluene with chloroacetonitrile occurred regioselectively, with the formation of 4,6-dihydroxy-7-methylbenzofuran-3(2H)-one, the treatment of which with substituted benzaldehydes gave high yields of the target compounds.
- Published
- 2019
38. OCCLUDED GASES EFFECT ON ACOUSTIC EMISSION UNDER CRYSTAL SALVATION
- Author
-
Dmitry M. Kuznetsov, Petr N. Kozachenko, and Olga O. Barannikova
- Subjects
acoustic waves ,crystallisation ,salvation ,occluded gases. ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
The acoustic emission following the salt solution processes is investigated. It is educed that the acoustic emission parameters depend on the substance chemistry. It is stated that irrespective of the crystal purity degree with their dissolution the total count of signals increases logarithmically, and activity of the acoustic emission decreases exponentially. It is shown that the occluded gases liberation is a crucial element of the acoustic emission under the crystal dissolution.
- Published
- 2011
39. INVESTIGATING IMPREGNATION BY ACOUSTIC EMISSION METHOD
- Author
-
Vladimir L. Gaponov, Dmitry M. Kuznetsov, Ekaterina S. Cherunova, and Olga O. Barannikova
- Subjects
acoustic emission ,impregnation of materials ,liquid degassing ,nondestructive control method. ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
The possibility of applying the acoustic emission method to studying the impregnation of various materials with liquid has been investigated. It is shown that in the process of liquid outgassing while impregnating hard materials, several different acoustic-emission patterns are identified. This indicates complexity and multistage character of the impregnation process. The data obtained permit to forecast the sphere of the AE method application as a nondestructive technique of depth and dip fullness control.
- Published
- 2011
40. The C60-Fullerene Porphyrin Adducts for Prevention of the Doxorubicin-Induced Acute Cardiotoxicity in Rat Myocardial Cells
- Author
-
Seyed Vahid Shetab Boushehri, Seyed Nasser Ostad, Saeed Sarkar, Dmitry A. Kuznetsov, Anatoly L. Buchachenko, Marina A. Orlova, Bagher Minaii, Abbas Kebriaeezadeh, and Seyed Mahdi Rezayat
- Subjects
Fullerene nanoparticles ,doxorubicin-induced cardiotoxicity ,25Mg2+ ,mitochondrial dysfunctions ,Medicine (General) ,R5-920 - Abstract
"nThis is a fullerene-based low toxic nanocationite designed for targeted delivery of the paramagnetic stable isotope of magnesium to the doxorubicin (DXR)-induced damaged heart muscle providing a prominent effect close to about 80% recovery of the tissue hypoxia symptoms in less than 24 hrs after a single injection (0.03 - 0.1 LD50). Magnesium magnetic isotope effect selectively stimulates the ATP formation in the oxygen-depleted cells due to a creatine kinase (CK) and mitochondrial respiratory chain-focusing "attack" of 25Mg2+ released by nanoparticles. These "smart nanoparticles" with membranotropic properties release the overactivating cations only in response to the intracellular acidosis. The resulting positive changes in the energy metabolism of heart cell may help to prevent local myocardial hypoxic (ischemic) disorders and, hence, to protect the heart muscle from a serious damage in a vast variety of the hypoxia-induced clinical situations including DXR side effects.
- Published
- 2010
41. Digital Slot: A Tool for Optimization and Development of New Hydraulic Fracturing Technologies
- Author
-
Alexey Tikhonov, Maxim Grigorievich Ivanov, Ivan Velikanov, Dmitry Sergeevich Kuznetsov, Leonid Semin, Ludmila Belyakova, Semen Vasilievich Idimeshev, Denis Bannikov, and Vadim Isaev
- Subjects
Hydraulic fracturing ,Development (topology) ,Petroleum engineering ,Geology - Abstract
We present the digital slot — a tool for the development of new hydraulic fracturing technologies via digitization of slurry flow in narrow channels. We consider slurry containing fluid, proppant, and fiber components. The flow is described by a continuum mathematical model based on the lubrication theory. The numerical algorithm utilizes Lagrangian approach with finite volume pressure solver. We present the results of laboratory validation and simulation examples showing the key effects affecting solids transport in hydraulic fracturing: settling, bridging, gravity slumping, materials degradation, viscosity contrast, and bank formation.
- Published
- 2021
42. RESEARCH OF LEGAL REGULATION OF PERSONNEL SAFETY OF THE PHARMACEUTICAL ORGANIZATIONS IN RUSSIA
- Author
-
Marina U Klisсhenko and Dmitry A Kuznetsov
- Subjects
Pharmacology ,business.industry ,Personnel safety ,Pharmaceutical Science ,Pharmacology (medical) ,Public relations ,business - Abstract
Objective: The study consists in the analysis of the main regulatory acts governing personnel safety in pharmaceutical organizations. In the process of managing a pharmaceutical organization, the leader must rely on the requirements of current legislation in the field of personnel safety. Safety is the main strategic activity of any pharmaceutical organization. The legal framework governing personnel security is constantly expanding. Actually study the fundamental standards of personnel safety. Methods: The methods of analysis were a systematic approach, logical grouping, content analysis of the main documents regulating personnel security in the pharmaceutical industry. Results: The fundamental regulatory acts were identified that play a major role in ensuring and regulating the personnel safety of pharmaceutical organizations. Personnel security is a key element of the economic security of a pharmaceutical organization. The management of pharmaceutical personnel in the personnel safety system consists in finding ways to minimize risks and threats from and in relation to employees. The basic regulatory acts in the system of personnel security are identified, which allow to level threats and optimize the sustainable development of the pharmaceutical organization. Conclusion: In Russia, the legal basis for the personnel security of pharmaceutical organizations is: the Constitution; international treaties; federal constitutional laws; federal laws and regulations; Government Decisions; laws and other regulatory legal acts of entities. The term “security” is introduced by the law “On Security”. The main security threats are identified in the Economic Security Strategy for the period until 2030.
- Published
- 2019
43. Features of formation and structure of silicon–polysaccharide-containing polyolate hydrogels obtained by the method of biomimetic mineralization
- Author
-
Maria E. Novoselova, Dmitry K. Kuznetsov, Elena Nikitina, T. G. Khonina, M. V. Ivanenko, E. V. Shadrina, and M. S. Karabanalov
- Subjects
Green chemistry ,Materials science ,02 engineering and technology ,010402 general chemistry ,Polysaccharide ,01 natural sciences ,Biomaterials ,Chitosan ,chemistry.chemical_compound ,Materials Chemistry ,medicine ,chemistry.chemical_classification ,Syneresis ,technology, industry, and agriculture ,Cationic polymerization ,General Chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,chemistry ,Chemical engineering ,Self-healing hydrogels ,Ceramics and Composites ,0210 nano-technology ,Xanthan gum ,Hydroxyethyl cellulose ,medicine.drug - Abstract
We have demonstrated that our patented water-soluble biocompatible polyolate precursors of silicon tetraglycerolate and silicon tetrapolyethylene glycolate can be successfully utilized in biomimetical mineralization of polysaccharides of different nature. By the example of chitosan (cationic), xanthan gum (anionic), and hydroxyethyl cellulose (uncharged) polysaccharides, an accelerating effect on the gelation process has been demonstrated, and a stabilizing effect has been revealed on the hydrogels formed as transparent monoliths showing resistance to syneresis. Structural features of silicon–polysaccharide-containing hydrogels were investigated using advanced physical methods of cryo-scanning electron microscopy and transmission electron microscopy. Thus formed silicon-containing 3D network of gels is found to be polymeric and appears to have an ordered amorphous morphostructure, which can be explained as caused by the effect of polysaccharides serving as templates. The difference in the reactivity of precursors leads to the peculiarities of the gelation process in the presence of the polysaccharides under study, as well as to the difference in the composition of the formed products. The sol-gel process utilized to obtain the silicon–polysaccharide-containing hydrogels proceeds under the mild conditions with no catalyst or any organic solvent, and thus can be regarded as belonging to the green chemistry methods that show promise for biomedical material applications.
- Published
- 2019
44. Primer-Like Inhibitors for DNA Repair Enzymes of the AML-HL60 and WERI-1A/Y79 Malignant Cells
- Author
-
Kirill V. Ermakov, Sergei V. Stovbun, Alexander S. Vedenkin, Dmitry A. Kuznetsov, and Alexander A. Bukhvostov
- Subjects
0301 basic medicine ,030102 biochemistry & molecular biology ,biology ,DNA polymerase ,DNA repair ,Chemistry ,HL60 ,Cell ,Chromatin ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,medicine.anatomical_structure ,Biochemistry ,biology.protein ,medicine ,General Materials Science ,Primer (molecular biology) ,Pharmacophore ,DNA - Abstract
A conventionally synthesized thio- and cyano-modified single-stranded poly(dNTP) sequences of different molecular sizes (20n - 200n) and the same lengths routine poly(dNTP) and poly(NTP) species were obtained through the good services provided by the Russian Federal Bioorganic Products Group and by the ThermoFischer, Inc., and then tested for their impact on catalytic activities of β-like DNA polymerases from chromatin of HL-60, WERI-1A and Y-79 cells as well as for the affinity patterns in DNApolβ-poly(dNTP)/ (NTP) pairs, respectively. An essential link between the lengths of ultrashort (50n - 100n) single-stranded poly(dNTP) sequences of different structures and their inhibitory effects towards the cancer-specific DNA polymerases β has been found. A possible significance of this phenomenon for both DNA repair suppression in tumors and a consequent anti-cancer activity of the DNA repair related short poly(dNTP) fragments has been for the first time emphasized with a respect to their pharmacophore revealing potential. Thus, this work presents an experimental attempt to upgrade a contemporary attitude towards the DNA derived products applied for anti-cancer agenda, particularly, for acute myeloid leukemia and retinoblastoma cell DNA repair machinery breakdown. In this study, tumor specific DNA polymerases β were found of being the targets for attack promoted with the primer-like single-stranded DNA fragments followed by consequent cytostatic phenomena. A novel concept of the DNA related anti-cancer medicines is under discussion.
- Published
- 2019
45. Synthesis and properties of azo compounds based on nitroanilines - 2,4,6-trinitrotoluene derivatives and 1,3,5-trinitrobenzene
- Author
-
Nikolay M. Sharpar, K. I. Kobrakov, A. G. Ruchkina, and Dmitry N. Kuznetsov
- Subjects
chemistry.chemical_compound ,Chemistry ,Organic chemistry ,Trinitrotoluene ,1,3,5-Trinitrobenzene - Published
- 2019
46. Ultrashort ssDNA in Retinoblastoma Patients Blood Plasma Detected by a Novel High Resolution HPLC Technique: a Preliminary Report
- Author
-
Alexander A. Bukhvostov, Alexander S. Vedenkin, Anton S. Dvornikov, Dmitry A. Kuznetsov, Kirill V. Ermakov, and Sergey V. Stovbun
- Subjects
Adult ,Male ,Retinal Neoplasms ,Population ,lcsh:Medicine ,DNA, Single-Stranded ,High resolution ,hplc ,High-performance liquid chromatography ,chemistry.chemical_compound ,Preliminary report ,Blood plasma ,Biomarkers, Tumor ,medicine ,Humans ,education ,Chromatography, High Pressure Liquid ,education.field_of_study ,Chromatography ,Retinoblastoma ,lcsh:R ,Analytical technique ,General Medicine ,medicine.disease ,chemistry ,Case-Control Studies ,Child, Preschool ,ssdna ,cfdna ,DNA ,blood plasma - Abstract
A significant population of ultrashort (50–150n) single-stranded DNA fragments were found in exosome-free blood plasma of retinoblastoma patients (6.84 ng mL−1), but not in plasma of healthy donors. An original high resolution HPLC technique has been proposed to reveal and characterize this peculiarity. To solve this task, a novel molecular size exclusion – anion exchange analytical technique was developed. Its applicability to diagnostics and oncogenesis research is quizzed here.
- Published
- 2019
47. The first detection of Ashworthius sidemi (Nematoda, Trichostrongylidae) in roe deer (Capreolus capreolus) in Russia
- Author
-
Boris V. Romashov, Natalya B. Romashova, and Dmitry M. Kuznetsov
- Subjects
Male ,0301 basic medicine ,Zoology ,Biology ,Trichostrongyloidiasis ,Russia ,03 medical and health sciences ,Capreolus ,Ruminant ,biology.animal ,Animals ,Juvenile ,Parasite hosting ,Cervus ,Trichostrongyloidea ,General Veterinary ,Deer ,biology.organism_classification ,Europe ,Roe deer ,Ashworthius sidemi ,030104 developmental biology ,Nematode ,DNA, Intergenic ,Female ,Parasitology - Abstract
Ashworthius sidemi is a blood-sucking nematode, which has spread out among wild ruminants in several European countries during last decades. The nematode has recently been detected in cattle as well. The distribution of A. sidemi in Russia has not been sufficiently clarified yet. In European part of Russia A. sidemi was formerly registered in sika deer (Cervus nippon) and maral (Cervus elaphus sibiricus) introduced from Asia, and also in aboriginal elks (Alces alces). Taking into consideration the presence of other species of ruminants susceptible to A. sidemi in European Russia, it is necessary to control the spread of this parasite. The specimens of males and females of A. sidemi were found during the autopsies of three naturally infected roe deer (Capreolus capreolus) from Voronezh and Tver regions (European Russia). The species affiliation of the discovered nematodes was determined according to morphological features and confirmed using molecular techniques. The intensity of infection with A. sidemi in two roe deer from Voronezh was 11 and 63 nematodes, and it was 17 nematodes in roe deer from Tver. All of the discovered specimens of A. sidemi were referred to juvenile forms based on features of male bursa morphology and weak development of female reproductive system. In Russia, A. sidemi has not previously been detected in C. capreolus and the present report constitutes the first record of the parasite occurrence in this species of ruminant.
- Published
- 2018
48. Antiviral potential of plant polysaccharide nanoparticles actuating non-specific immunity☆
- Author
-
Sergey V. Stovbun, Dmitry V. Zlenko, Aleksei V. Kiselev, Alexander A. Bukhvostov, Sergey V. Usachev, Tatiana S. Kalinina, Dmitry A. Kuznetsov, and Alexander A. Litvin
- Subjects
Drug ,Adult ,Male ,Adolescent ,Phagocytosis ,media_common.quotation_subject ,HL-60 Cells ,02 engineering and technology ,Biology ,Pharmacology ,Polysaccharide ,Biochemistry ,Antiviral Agents ,Article ,Proinflammatory cytokine ,03 medical and health sciences ,Structural Biology ,Auxin ,Polysaccharides ,Humans ,Secretion ,Antiviral activity ,Molecular Biology ,030304 developmental biology ,media_common ,Immune modulator ,chemistry.chemical_classification ,0303 health sciences ,Drug Carriers ,Innate immune system ,food and beverages ,COVID-19 ,General Medicine ,Plants ,021001 nanoscience & nanotechnology ,COVID-19 Drug Treatment ,Probucol ,chemistry ,Nanoparticles ,0210 nano-technology ,Drug carrier - Abstract
The development of high-end targeted drugs and vaccines against modern pandemic infections, such as COVID-19, can take a too long time that lets the epidemic spin up and harms society. However, the countermeasures must be applied against the infection in this period until the targeted drugs became available. In this regard, the non-specific, broad-spectrum anti-viral means could be considered as a compromise allowing overcoming the period of trial. One way to enhance the ability to resist the infection is to activate the nonspecific immunity using a suitable driving-up agent, such as plant polysaccharides, particularly our drug Panavir isolated from the potato shoots. Earlier, we have shown the noticeable anti-viral and anti-bacterial activity of Panavir. Here we demonstrate the pro-inflammation activity of Panavir, which four-to-eight times intensified the ATP and MIF secretion by HL-60 cells. This effect was mediated by the active phagocytosis of the Panavir particles by the cells. We hypothesized the physiological basis of the Panavir proinflammatory activity is mediated by the indol-containing compounds (auxins) present in Panavir and acting as a plant analog of serotonin.
- Published
- 2021
49. Nematodes of birds of Armenia
- Author
-
Sergey O, Movsesyan, Egor A, Vlasov, Manya A, Nikoghosian, Rosa A, Petrosian, Mamikon G, Ghasabyan, and Dmitry N, Kuznetsov
- Subjects
Nematoda ,Animals ,Passeriformes ,Armenia - Abstract
The review provides data on species composition of nematodes in 50 species of birds from Armenia (South of Lesser Caucasus). Most of the studied birds belong to Passeriformes and Charadriiformes orders. One of the studied species of birds (Larus armenicus) is an endemic. The taxonomy and host-specificity of nematodes reported in original papers are discussed with a regard to current knowledge about this point. In total, 52 nematode species parasitizing birds in Armenia are reported. Most of the reported species of nematodes are quite common in birds outside of Armenia. One species (Desmidocercella incognita from great cormorant) was first identified in Armenia. Great snipe was recorded as a new host for Hystrichis tricolor. Zoonotic nematode Trichinella pseudospiralis was reported in Armenia from Eurasian blackbird.
- Published
- 2021
50. Information Technologies in the Context of Forming the Synergy of Post-industrial Consciousness and Digital Economy
- Author
-
Natalya V. Vlasova, Ekaterina S. Timofeeva, Dmitry V. Kuznetsov, Shamsaddin Z. Mehdiev, and Maxim S. Chistyakov
- Subjects
Civilization ,business.industry ,Process (engineering) ,media_common.quotation_subject ,Post-industrial society ,Information technology ,Context (language use) ,Engineering ethics ,Relevance (information retrieval) ,Sociology ,Digital economy ,Consciousness ,business ,media_common - Abstract
In the collective author’s work on the basis of general scientific methodological approaches, the revolutionary transformation of modern civilization into the format of a post-industrial state and network thinking under the influence of information technologies is considered, taking into account the relevance of awareness of threats to humanity during the convergence of digitalization into everyday reality. The main approach is a theoretical analysis of the impact of modern information technologies and their extrapolation to the near future of civilization from the point of view of the feasibility of creating favorable conditions for life, human improvement from the standpoint of improving moral, ethical, psychological and intellectual qualities. The results, which were obtained, can be used from the position of an interdisciplinary approach as a subjective scientific position of the authors of the article on the evolution of the post-industrial society and the assessment of possible variations in the development of the post-industrial economy on the platform of information technologies, which are part of the convergent ones that form the basis of the VI technological order of the IV industrial revolution. The authors explain that the reasoning given in the article isn’t a dogma and can be transformed directly by the spokesmen of these opinions and by other authors of other works on the topic of post-industrial development in the process of scientific discussions.
- Published
- 2021
Catalog
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