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104 results on '"Dmitri Kireev"'

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1. In silico fragment-based discovery of CIB1-directed anti-tumor agents by FRASE-bot

2. Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant

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3. MERTK activation drives osimertinib resistance in EGFR-mutant non–small cell lung cancer

4. A simulation model of heterochromatin formation at submolecular detail

6. A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors.

7. Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε.

9. PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components

10. Structural basis of paralog-specific KDM2A/B nucleosome recognition

11. Enzymatic Macrolactamization of mRNA Display Libraries for Inhibitor Selection

12. Supplementary Figure 3 from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo

13. Supplementary Figure 2 from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo

14. Supplementary Figure 1 from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo

15. Supplementary Figure 5 from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo

16. Supplementary Figure 4 from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo

17. Multivalent DNA and nucleosome acidic patch interactions specify VRK1 mitotic localization and activity

18. Relationship between lysine methyltransferase levels and heterochromatin gene repression in living cells and in silico

19. A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization

20. Discovery and Development of Cyclic Peptide Inhibitors of CIB1

21. Development of a High-Throughput TR-FRET Screening Assay for a Fast-Cycling KRAS Mutant

23. Combining Pharmacophore Models Derived from DNA-Encoded Chemical Libraries with Structure-Based Exploration to Predict Tankyrase 1 Inhibitors

25. AD Informer Set: Chemical tools to facilitate Alzheimer’s disease drug discovery

26. Off-Pocket Activity Cliffs: A Puzzling Facet of Molecular Recognition

27. Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology

28. Synthesis and Antibacterial Evaluation of Cephalosporin Isosteres

29. A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes

30. MERTK activation drives osimertinib resistance in EGFR-mutant non-small cell lung cancer

31. Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization

32. REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR

33. Correction to 'A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes'

35. Identification of Cosalane as an Inhibitor of Human and Murine CC–Chemokine Receptor 7 Signaling via a High-Throughput Screen

36. Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group

37. UNC5293, a potent, orally available and highly MERTK-selective inhibitor

38. Discovery of selective activators of PRC2 mutant EED-I363M

39. Dynamics of substrate processing by PPIP5K2, a versatile catalytic machine

40. A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD

41. Discovery and Characterization of a Cellularly Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7

42. Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors

43. Identification of Small Molecule Inhibitors That Block the Toxoplasma gondii Rhoptry Kinase ROP18

44. Integrating DNA-encoded chemical libraries with virtual combinatorial library screening: Optimizing a PARP10 inhibitor

45. Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins

46. Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1

47. Structural Protein–Ligand Interaction Fingerprints (SPLIF) for Structure-Based Virtual Screening: Method and Benchmark Study

48. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7

50. UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo