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5. Development of Surgical Tools and Procedures for Experimental Preclinical Surgery Using Computer Simulations And 3D Printing

Author

Barcik, Jan, primary, Ernst, Manuela, additional, Schwyn, Ronald, additional, Freitag, Linda, additional, Dlaska, Constantin Edmond, additional, Drenchev, Ludmil, additional, Todorov, Stoil, additional, Skulev, Hristo, additional, Epari, Devakara R., additional, Zeiter, Stephan, additional, and Gueorguiev, Boyko, additional

Published
2020
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6. Development of surgical tools and procedures for experimental preclinical surgery using computer simulations and 3D printing

Author

Barcik, Jan, Ernst, Manuela, Schwyn, Ronald, Freitag, Linda, Dlaska, Constantin Edmond, Drenchev, Ludmil, Todorov, Stoil, Skulev, Hristo, Epari, Devakara R., Zeiter, Stephan, Gueorguiev, Boyko, Barcik, Jan, Ernst, Manuela, Schwyn, Ronald, Freitag, Linda, Dlaska, Constantin Edmond, Drenchev, Ludmil, Todorov, Stoil, Skulev, Hristo, Epari, Devakara R., Zeiter, Stephan, and Gueorguiev, Boyko

Abstract

Experimental preclinical surgeries require high accuracy and repeatability in all applied procedures. For in vivo studies investigating bone fracture healing it is crucial to create precisely and consistently the experimental bone fractures in all included subjects. In large animal models the required precision is usually achieved by application of dedicated drilling jigs and cutting guides that often need to be individually designed in order to fulfil the requirements of a particular experiment. Moreover, their final design may considerably differ from the prototypes. Hence, the designing and testing processes require multiple iterative refinement loops substantially increasing the costs of the experiment. Therefore, a framework for development of tailor-made instruments for experimental preclinical surgeries is established to reduce the investment of time and financial effort.

Published
2020

7. Early mechanical stimulation only permits timely bone healing in sheep

Author

Tufekci, Pelin Melisa, Tavakoli, Aramesh, Dlaska, Constantin Edmond, Neumann, Mirjam V., Shanker, Mihir, Saifzadeh, Siamak, Steck, Roland, Schuetz, Michael, and Epari, Devakara R.

Subjects
090302 Biomechanical Engineering, ovine model, bone healing, mechanical stimulation, interfragmentary movement, 110314 Orthopaedics
Abstract

Bone fracture healing is sensitive to the fixation stability. However, it is unclear which phases of healing are mechano-sensitive and if mechanical stimulation is required throughout repair. In this study, a novel bone defect model, which isolates an experimental fracture from functional loading, was applied in sheep to investigate if stimulation limited to the early proliferative phase is sufficient for bone healing. An active fixator controlled motion in the fracture. Animals of the control group were unstimulated. In the physiological-like group, 1 mm axial compressive movements were applied between day 5 and 21, thereafter the movements were decreased in weekly increments and stopped after 6 weeks. In the early stimulatory group, the movements were stopped after 3 weeks. The experimental fractures were evaluated with mechanical and micro-computed tomography methods after 9 weeks healing. The callus strength of the stimulated fractures (physiological-like and early stimulatory) was greater than the unstimulated control group. The control group was characterized by minimal external callus formation and a lack of bone bridging at 9 weeks. In contrast, the stimulated groups exhibited advanced healing with solid bone formation across the defect. This was confirmed quantitatively by a lower bone volume in the control group compared to the stimulated groups.The novel experimental model permits the application of a well-defined load history to an experimental bone fracture. The poor healing observed in the control group is consistent with under-stimulation. This study has shown early mechanical stimulation only is sufficient for a timely healing outcome.

Published
2018

8. Full control of the fracture: A novel in-vivo method that allows studying the mechanobiology of a fracture

Author

Dlaska, Constantin Edmond, Tufekci, Pelin, Tavakoli, Aramesh, Shanker, Mihir, Saifzadeh@qut.edu.au, Siamak, Windolf, Markus, Schütz, Michael, and Epari, Devakar

Subjects
ddc: 610, ovine model, 610 Medical sciences, Medicine, mechanobiology, mechanical stimulation, interfragmentary movement
Abstract

Objectives: Bone fracture healing is known to be sensitive to the degree of fixation stability. However, it is unclear which biological processes during healing are mechano-sensitive and if mechanical stimulation is required during all stages of repair. The science of how mechanical and physical stimuli[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2017)

Published
2017

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