1,047 results on '"Djoussé, Luc"'
Search Results
2. Dysregulated carbohydrate and lipid metabolism and risk of atrial fibrillation in advanced old age.
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Buzkova, Petra, Oesterle, Adam, Heckbert, Susan, Tracy, Russell, Siscovick, David, Mukamal, Kenneth, Djoussé, Luc, Kizer, Jorge, and Pellegrini, Cara
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atrial fibrillation ,epidemiology ,Male ,Humans ,Female ,Aged ,Aged ,80 and over ,Atrial Fibrillation ,Lipid Metabolism ,Follow-Up Studies ,Prospective Studies ,Electrocardiography ,Risk Factors ,Glucose ,Incidence - Abstract
OBJECTIVE: Obesity and dysmetabolism are major risk factors for atrial fibrillation (AF). Fasting and postload levels of glucose and non-esterified fatty acids (NEFAs) reflect different facets of metabolic regulation. We sought to study their respective contributions to AF risk concurrently. METHODS: We assessed levels of fasting and postload glucose and NEFA in the Cardiovascular Health Study to identify associations with AF incidence and, secondarily, with ECG parameters of AF risk available at baseline. Linear and Cox regressions were performed. RESULTS: The study included 1876 participants (age 77.7±4.4). During the median follow-up of 11.4 years, 717 cases of incident AF occurred. After adjustment for potential confounders, postload glucose showed an association with incident AF (HR per SD increment of postload glucose=1.11, 95% CI 1.02 to 1.21, p=0.017). Both glucose measures, but not NEFA, were positively associated with higher P wave terminal force in V1 (PTFV1); the association remained significant only for postload glucose when the two measures were entered together (β per SD increment=138 μV·ms, 95% CI 15 to 260, p=0.028). Exploratory analyses showed significant interaction by sex for fasting NEFA (pinteraction=0.044) and postload glucose (pinteraction=0.015) relative to AF, with relationships stronger in women. For postload glucose, the association with incident AF was observed among women but not among men. CONCLUSIONS: Among older adults, postload glucose was positively associated with incident AF, with consistent findings for PTFV1. In exploratory analyses, the relationship with AF appeared specific to women. These findings require further study but suggest that interventions to address postprandial dysglycaemia late in life might reduce AF.
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- 2023
3. A population‐based meta‐analysis of circulating GFAP for cognition and dementia risk
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Gonzales, Mitzi M, Wiedner, Crystal, Wang, Chen‐Pin, Liu, Qianqian, Bis, Joshua C, Li, Zhiguang, Himali, Jayandra J, Ghosh, Saptaparni, Thomas, Emy A, Parent, Danielle M, Kautz, Tiffany F, Pase, Matthew P, Aparicio, Hugo J, Djoussé, Luc, Mukamal, Kenneth J, Psaty, Bruce M, Longstreth, William T, Mosley, Thomas H, Gudnason, Vilmundur, Mbangdadji, Djass, Lopez, Oscar L, Yaffe, Kristine, Sidney, Stephen, Bryan, R Nick, Nasrallah, Ilya M, DeCarli, Charles S, Beiser, Alexa S, Launer, Lenore J, Fornage, Myriam, Tracy, Russell P, Seshadri, Sudha, and Satizabal, Claudia L
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Neurodegenerative ,Prevention ,Dementia ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Acquired Cognitive Impairment ,Alzheimer's Disease ,Neurosciences ,Brain Disorders ,Aging ,Bioengineering ,Clinical Research ,Neurological ,Alzheimer Disease ,Antihypertensive Agents ,Apolipoproteins ,Cognition ,Glial Fibrillary Acidic Protein ,Humans ,Clinical Sciences - Abstract
ObjectiveExpression of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytosis, colocalizes with neuropathology in the brain. Blood levels of GFAP have been associated with cognitive decline and dementia status. However, further examinations at a population-based level are necessary to broaden generalizability to community settings.MethodsCirculating GFAP levels were assayed using a Simoa HD-1 analyzer in 4338 adults without prevalent dementia from four longitudinal community-based cohort studies. The associations between GFAP levels with general cognition, total brain volume, and hippocampal volume were evaluated with separate linear regression models in each cohort with adjustment for age, sex, education, race, diabetes, systolic blood pressure, antihypertensive medication, body mass index, apolipoprotein E ε4 status, site, and time between GFAP blood draw and the outcome. Associations with incident all-cause and Alzheimer's disease dementia were evaluated with adjusted Cox proportional hazard models. Meta-analysis was performed on the estimates derived from each cohort using random-effects models.ResultsMeta-analyses indicated that higher circulating GFAP associated with lower general cognition (ß = -0.09, [95% confidence interval [CI]: -0.15 to -0.03], p = 0.005), but not with total brain or hippocampal volume (p > 0.05). However, each standard deviation unit increase in log-transformed GFAP levels was significantly associated with a 2.5-fold higher risk of incident all-cause dementia (Hazard Ratio [HR]: 2.47 (95% CI: 1.52-4.01)) and Alzheimer's disease dementia (HR: 2.54 [95% CI: 1.42-4.53]) over up to 15-years of follow-up.InterpretationResults support the potential role of circulating GFAP levels for aiding dementia risk prediction and improving clinical trial stratification in community settings.
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- 2022
4. Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 1·97 million adults with 100 000 incident cases from 31 cohorts in 20 countries
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Li, Chunxiao, Bishop, Tom R P, Imamura, Fumiaki, Sharp, Stephen J, Pearce, Matthew, Brage, Soren, Ong, Ken K, Ahsan, Habibul, Bes-Rastrollo, Maira, Beulens, Joline W J, den Braver, Nicole, Byberg, Liisa, Canhada, Scheine, Chen, Zhengming, Chung, Hsin-Fang, Cortés-Valencia, Adrian, Djousse, Luc, Drouin-Chartier, Jean-Philippe, Du, Huaidong, Du, Shufa, Duncan, Bruce B, Gaziano, J Michael, Gordon-Larsen, Penny, Goto, Atsushi, Haghighatdoost, Fahimeh, Härkänen, Tommi, Hashemian, Maryam, Hu, Frank B, Ittermann, Till, Järvinen, Ritva, Kakkoura, Maria G, Neelakantan, Nithya, Knekt, Paul, Lajous, Martin, Li, Yanping, Magliano, Dianna J, Malekzadeh, Reza, Le Marchand, Loic, Marques-Vidal, Pedro, Martinez-Gonzalez, Miguel A, Maskarinec, Gertraud, Mishra, Gita D, Mohammadifard, Noushin, O'Donoghue, Gráinne, O'Gorman, Donal, Popkin, Barry, Poustchi, Hossein, Sarrafzadegan, Nizal, Sawada, Norie, Schmidt, Maria Inês, Shaw, Jonathan E, Soedamah-Muthu, Sabita, Stern, Dalia, Tong, Lin, van Dam, Rob M, Völzke, Henry, Willett, Walter C, Wolk, Alicja, Yu, Canqing, Forouhi, Nita G, and Wareham, Nicholas J
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- 2024
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5. Fasting and Postload Nonesterified Fatty Acids and Glucose Dysregulation in Older Adults.
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Shitole, Sanyog G, Biggs, Mary L, Ix, Joachim H, Fretts, Amanda M, Tracy, Russell P, Siscovick, David S, Djoussé, Luc, Mukamal, Kenneth J, and Kizer, Jorge R
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Epidemiology ,Health Sciences ,Nutrition ,Diabetes ,Prevention ,Metabolic and endocrine ,Aged ,Blood Glucose ,Diabetes Mellitus ,Type 2 ,Fasting ,Fatty Acids ,Nonesterified ,Female ,Glucose ,Humans ,Insulin ,Insulin Resistance ,Male ,Prospective Studies ,beta cell function ,diabetes ,insulin sensitivity ,nonesterified fatty acids ,older adults ,Mathematical Sciences ,Medical and Health Sciences - Abstract
To evaluate the association of nonesterified fatty acids (NEFA) with dysglycemia in older adults, NEFA levels were measured among participants in the Cardiovascular Health Study (United States; enrolled 1989-1993). Associations with insulin sensitivity and pancreatic β-cell function, and with incident type 2 diabetes mellitus (DM), were examined. The sample comprised 2,144 participants (aged 77.9 (standard deviation, 4.5) years). Participant data from the Cardiovascular Health Study visit in 1996-1997 was used with prospective follow-up through 2010. Fasting and postload NEFA showed significant associations with lower insulin sensitivity and pancreatic β-cell function, individually and on concurrent adjustment. Over median follow-up of 9.7 years, 236 cases of DM occurred. Postload NEFA were associated with risk of DM (per standard deviation, hazard ratio = 1.18, 95% confidence interval: 1.08, 1.29), but fasting NEFA were not (hazard ratio = 1.12, 95% confidence interval: 0.97, 1.29). The association for postload NEFA persisted after adjustment for putative intermediates, and after adjustment for fasting NEFA. Sex and body mass index modified these associations, which were stronger for fasting NEFA with DM in men but were accentuated for postload NEFA in women and among leaner individuals. Fasting and postload NEFA were related to lower insulin sensitivity and pancreatic β-cell function, but only postload NEFA were associated with increased DM. Additional study into NEFA metabolism could uncover novel potential targets for diabetes prevention in elders.
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- 2022
6. Initiation of Statins for Primary Prevention in Heart Failure With Preserved Ejection Fraction
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Orkaby, Ariela R., Goyal, Parag, Charest, Brian, Qazi, Saadia, Sheikh, Shamlan, Shah, Sanjiv, Gaziano, J. Michael, Djousse, Luc, Gagnon, David, and Joseph, Jacob
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- 2024
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7. Moderate alcohol consumption on the risk of stroke in the Million Veteran Program
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Song, Rebecca J., Larson, Martin G., Aparicio, Hugo J., Gaziano, J. Michael, Wilson, Peter, Cho, Kelly, Vasan, Ramachandran S., Fox, Matthew P., and Djoussé, Luc
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- 2023
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8. Body Composition and Incident Heart Failure in Older Adults: Results From 2 Prospective Cohorts
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Zhang, Lili, Bartz, Traci M, Santanasto, Adam, Djoussé, Luc, Mukamal, Kenneth J, Forman, Daniel E, Hirsch, Calvin H, Newman, Anne B, Gottdiener, John S, and Kizer, Jorge R
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Cardiovascular ,Nutrition ,Heart Disease ,Clinical Research ,Prevention ,Aging ,2.1 Biological and endogenous factors ,Aetiology ,Absorptiometry ,Photon ,Aged ,Body Composition ,Body Mass Index ,Heart Failure ,Humans ,Muscle ,Skeletal ,Prospective Studies ,adiposity ,body composition ,heart failure ,skeletal muscle ,Cardiorespiratory Medicine and Haematology - Abstract
Background Aging is associated with central fat redistribution and skeletal muscle decline, yet the relationships of tissue compartments with heart failure (HF) remain incompletely characterized. We assessed the contribution of body composition to incident HF in elders. Methods and Results Participants from 2 older cohorts who completed dual-energy X-ray absorptiometry (DEXA) and, in one cohort, computed tomography were included. We evaluated associations with incident HF for DEXA principal components (PCs) and total lean, appendicular lean, total fat and trunk fat mass; and for computed tomography measures of abdominal visceral and subcutaneous fat, thigh muscle, intermuscular fat area and thigh muscle density. DEXA analysis included 3621, and computed tomography analysis 2332 participants. During median follow-up of 11.8 years, 927 participants developed HF. DEXA principal components showed no relationship with HF. After adjustment for height, weight, and cardiovascular risk factors, total lean mass was near significantly associated with higher HF (hazard ratio [HR], 1.25 per SD [1.00-1.56]), whereas total fat mass and thigh muscle density were significantly related to lower HF (HR, 0.82 [0.68-0.99] and HR, 0.87 [0.78-0.97], respectively). Patterns were similar for HF subtypes. The relationships with HF for total lean and fat mass were attenuated after adjusting for intercurrent atrial fibrillation or excluding high natriuretic peptide levels. Conclusions Total lean mass was positively associated, while total fat mass and thigh muscle density were inversely associated, with incident HF. These findings highlight the limitations of DEXA for assessment of HF risk in elders and support the preeminence of computed tomography-measured skeletal muscle quality over mass as a determinant of HF incidence.
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- 2022
9. Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels
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Sarnowski, Chloé, Ghanbari, Mohsen, Bis, Joshua C, Logue, Mark, Fornage, Myriam, Mishra, Aniket, Ahmad, Shahzad, Beiser, Alexa S, Boerwinkle, Eric, Bouteloup, Vincent, Chouraki, Vincent, Cupples, L Adrienne, Damotte, Vincent, DeCarli, Charles S, DeStefano, Anita L, Djoussé, Luc, Fohner, Alison E, Franz, Carol E, Kautz, Tiffany F, Lambert, Jean-Charles, Lyons, Michael J, Mosley, Thomas H, Mukamal, Kenneth J, Pase, Matthew P, Portilla Fernandez, Eliana C, Rissman, Robert A, Satizabal, Claudia L, Vasan, Ramachandran S, Yaqub, Amber, Debette, Stephanie, Dufouil, Carole, Launer, Lenore J, Kremen, William S, Longstreth, William T, Ikram, M Arfan, and Seshadri, Sudha
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Biological Sciences ,Genetics ,Aging ,Neurosciences ,Neurodegenerative ,Alzheimer's Disease ,Dementia ,Brain Disorders ,Acquired Cognitive Impairment ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Black or African American ,Alzheimer Disease ,Exome ,Genome-Wide Association Study ,Humans ,Tauopathies ,Biological sciences ,Biomedical and clinical sciences - Abstract
Circulating total-tau levels can be used as an endophenotype to identify genetic risk factors for tauopathies and related neurological disorders. Here, we confirmed and better characterized the association of the 17q21 MAPT locus with circulating total-tau in 14,721 European participants and identified three novel loci in 953 African American participants (4q31, 5p13, and 6q25) at P
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- 2022
10. Egg Consumption and Cardiovascular Disease
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Imran, Tasnim F., primary, Toavs, Trevor, additional, Khalid, Mahnoor, additional, and Djoussé, Luc, additional
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- 2023
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11. Red Meat Intake and the Risk of Cardiovascular Diseases: A Prospective Cohort Study in the Million Veteran Program
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Wang, Dong D, Li, Yanping, Nguyen, Xuan-Mai, Ho, Yuk-Lam, Hu, Frank B, Willett, Walter C, Wilson, Peter WF, Cho, Kelly, Gaziano, J Michael, and Djoussé, Luc
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- 2024
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12. Impact of 8 lifestyle factors on mortality and life expectancy among United States veterans: The Million Veteran Program
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Nguyen, Xuan-Mai T, Li, Yanping, Wang, Dong D, Whitbourne, Stacey B, Houghton, Serena C, Hu, Frank B, Willett, Walter C, Sun, Yan V, Djousse, Luc, Gaziano, John Michael, Cho, Kelly, and Wilson, Peter WF
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- 2024
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13. Individual non-esterified fatty acids and incident atrial fibrillation late in life
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Pellegrini, Cara N, Buzkova, Petra, Lichtenstein, Alice H, Matthan, Nirupa R, Ix, Joachim H, Siscovick, David S, Heckbert, Susan R, Tracy, Russell P, Mukamal, Kenneth J, Djoussé, Luc, and Kizer, Jorge R
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Prevention ,Clinical Research ,Cardiovascular ,Heart Disease ,Aetiology ,2.1 Biological and endogenous factors ,Good Health and Well Being ,Aged ,Atrial Fibrillation ,Biomarkers ,Fatty Acids ,Nonesterified ,Female ,Follow-Up Studies ,Humans ,Incidence ,Male ,Prospective Studies ,Risk Assessment ,Risk Factors ,United States ,atrial fibrillation ,epidemiology ,metabolic syndrome ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
ObjectiveObesity and dysmetabolism are major risk factors for atrial fibrillation (AF). Expansion of fat depots is associated with increased circulating total non-esterified fatty acids (NEFAs), elevated levels of which are associated with incident AF. We undertook comprehensive serum measurement of individual NEFA to identify specific associations with new-onset AF late in life.MethodsThe present study focused on participants with available serum and free of AF selected from the Cardiovascular Health Study, a community-based longitudinal investigation of older US adults. Thirty-five individual NEFAs were measured by gas chromatography. Cox regression was used to evaluate the association of individual NEFAs with incident AF.ResultsThe study sample included 1872 participants (age 77.7±4.4). During median follow-up of 11.3 years, 715 cases of incident AF occurred. After concurrent adjustment of all NEFAs and full adjustment for potential confounders, higher serum concentration of nervonic acid (24:1 n-9), a long-chain monounsaturated fatty acid, was associated with higher risk of AF (HR per SD: 1.18, 95% CI 1.08 to 1.29; p
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- 2021
14. Research Priorities in the Secondary Prevention of Atrial Fibrillation: A National Heart, Lung, and Blood Institute Virtual Workshop Report
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Benjamin, Emelia J, Al‐Khatib, Sana M, Desvigne‐Nickens, Patrice, Alonso, Alvaro, Djoussé, Luc, Forman, Daniel E, Gillis, Anne M, Hendriks, Jeroen ML, Hills, Mellanie True, Kirchhof, Paulus, Link, Mark S, Marcus, Gregory M, Mehra, Reena, Murray, Katherine T, Parkash, Ratika, Piña, Ileana L, Redline, Susan, Rienstra, Michiel, Sanders, Prashanthan, Somers, Virend K, Van Wagoner, David R, Wang, Paul J, Cooper, Lawton S, and Go, Alan S
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Research ,Comparative Effectiveness Research ,Cardiovascular ,Prevention ,Clinical Trials and Supportive Activities ,Heart Disease ,Stroke ,Good Health and Well Being ,Animals ,Anti-Arrhythmia Agents ,Atrial Fibrillation ,Biomedical Research ,Body Composition ,Cardiac Rehabilitation ,Comorbidity ,Disease Progression ,Health Priorities ,Health Services Needs and Demand ,Healthy Lifestyle ,Humans ,National Heart ,Lung ,and Blood Institute (U.S.) ,Needs Assessment ,Recurrence ,Research Design ,Risk Assessment ,Risk Factors ,Secondary Prevention ,Treatment Outcome ,United States ,Weight Loss ,atrial fibrillation ,cardiac rehabilitation ,prevention ,research ,risk factors ,sleep ,Cardiorespiratory Medicine and Haematology ,Cardiovascular medicine and haematology - Abstract
There has been sustained focus on the secondary prevention of coronary heart disease and heart failure; yet, apart from stroke prevention, the evidence base for the secondary prevention of atrial fibrillation (AF) recurrence, AF progression, and AF-related complications is modest. Although there are multiple observational studies, there are few large, robust, randomized trials providing definitive effective approaches for the secondary prevention of AF. Given the increasing incidence and prevalence of AF nationally and internationally, the AF field needs transformative research and a commitment to evidenced-based secondary prevention strategies. We report on a National Heart, Lung, and Blood Institute virtual workshop directed at identifying knowledge gaps and research opportunities in the secondary prevention of AF. Once AF has been detected, lifestyle changes and novel models of care delivery may contribute to the prevention of AF recurrence, AF progression, and AF-related complications. Although benefits seen in small subgroups, cohort studies, and selected randomized trials are impressive, the widespread effectiveness of AF secondary prevention strategies remains unknown, calling for development of scalable interventions suitable for diverse populations and for identification of subpopulations who may particularly benefit from intensive management. We identified critical research questions for 6 topics relevant to the secondary prevention of AF: (1) weight loss; (2) alcohol intake, smoking cessation, and diet; (3) cardiac rehabilitation; (4) approaches to sleep disorders; (5) integrated, team-based care; and (6) nonanticoagulant pharmacotherapy. Our goal is to stimulate innovative research that will accelerate the generation of the evidence to effectively pursue the secondary prevention of AF.
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- 2021
15. Association of potato consumption with calcified atherosclerotic plaques in the coronary arteries: The NHLBI Family Heart Study
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Qavi, Ahmed Hassaan, Zhou, Guohai, Ward, Rachel E., Carr, John Jeffrey, Ellison, R. Curtis, Arnett, Donna K., Gaziano, J Michael, and Djousse, Luc
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- 2023
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16. The determinants of fasting and post-load non-esterified fatty acids in older adults: The cardiovascular health study
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Bene-Alhasan, Yakubu, Siscovick, David S., Ix, Joachim H., Kizer, Jorge R., Tracy, Russell, Djoussé, Luc, and Mukamal, Kenneth J.
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- 2023
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17. Associations of Serum Nonesterified Fatty Acids With Coronary Heart Disease Mortality and Nonfatal Myocardial Infarction: The CHS (Cardiovascular Health Study) Cohort
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Huang, Neil K, Bůžková, Petra, Matthan, Nirupa R, Djoussé, Luc, Hirsch, Calvin H, Kizer, Jorge R, Longstreth, WT, Mukamal, Kenneth J, and Lichtenstein, Alice H
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Heart Disease - Coronary Heart Disease ,Heart Disease ,Prevention ,Clinical Research ,Cardiovascular ,Good Health and Well Being ,Aged ,Biomarkers ,Coronary Disease ,Fatty Acids ,Nonesterified ,Female ,Follow-Up Studies ,Forecasting ,Humans ,Incidence ,Male ,Myocardial Infarction ,Retrospective Studies ,Risk Factors ,Survival Rate ,Time Factors ,United States ,coronary heart disease mortality ,dihomo‐ ,γ ,‐ ,linolenic acid ,epidemiology ,incident nonfatal myocardial infarction ,serum nonesterified fatty acid ,trans fat ,dihomo‐γ‐linolenic acid ,Cardiorespiratory Medicine and Haematology - Abstract
Background Significant associations have been reported between serum total nonesterified fatty acid (NEFA) concentrations and coronary heart disease (CHD) mortality and incident nonfatal myocardial infarction (MI) in some prospective cohort studies. Little is known about whether individual or subclasses (saturated, polyunsaturated [n-6 and n-3], and trans fatty acids) of serum NEFAs relate to CHD mortality and nonfatal MI. Methods and Results CHS (Cardiovascular Health Study) participants (N=1681) who had no history of MI, angina, or revascularization or were free of MI at baseline (1996-1997) were included. NEFAs were quantified using gas chromatography. Cox regression analysis was used to evaluate associations of 5 subclasses and individual NEFAs with CHD composite (CHD mortality and nonfatal MI), CHD mortality, and incident nonfatal MI. During a median follow-up of 11.7 years, 266 cases of CHD death and 271 cases of nonfatal MI occurred. In the fully adjusted model, no significant associations were identified between individual NEFA and CHD composite. Exploratory analyses indicated that lauric acid (12:0) was negatively associated (hazard ratio [HR], 0.76; 95% CI, 0.59-0.98; P=0.0328) and dihomo-γ-linolenic acid (20:3n-6) was positively associated with CHD mortality (HR, 1.34; 95% CI, 1.02-1.76; P=0.0351). Elaidic acid (18:1n-7t) was positively associated with incident nonfatal MI (HR, 1.46; 95% CI, 1.01-2.12; P=0.0445). No significant associations were observed for NEFA subclass and any outcomes. Conclusions In CHS participants, 2 NEFAs, dihomo-γ-linolenic and elaidic acids, were positively associated with CHD mortality and nonfatal MI, respectively, suggesting potential susceptibility biomarkers for risks of CHD mortality and nonfatal MI.
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- 2021
18. Non-esterified fatty acids and risk of peripheral artery disease in older adults: The cardiovascular health study
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Ahiawodzi, Peter, Solaru, Khendi White, Chaves, Paulo H.M., Ix, Joachim H., Kizer, Jorge R., Tracy, Russell P., Newman, Anne, Siscovick, David, Djousse, Luc, and Mukamal, Kenneth J.
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- 2023
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19. Soluble CD14 and CD14 Variants, Other Inflammatory Markers, and Glucose Dysregulation in Older Adults: The Cardiovascular Health Study
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Shitole, Sanyog G, Biggs, Mary L, Reiner, Alexander P, Mukamal, Kenneth J, Djoussé, Luc, Ix, Joachim H, Barzilay, Joshua I, Tracy, Russell P, Siscovick, David, and Kizer, Jorge R
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Epidemiology ,Health Sciences ,Diabetes ,Clinical Research ,Prevention ,2.1 Biological and endogenous factors ,Aetiology ,Metabolic and endocrine ,Aged ,Biomarkers ,Cardiovascular Diseases ,Cross-Sectional Studies ,Diabetes Mellitus ,Type 2 ,Female ,Glucose Intolerance ,Humans ,Incidence ,Inflammation ,Insulin Resistance ,Interleukin-6 ,Lipopolysaccharide Receptors ,Male ,Middle Aged ,Risk Factors ,Medical and Health Sciences ,Endocrinology & Metabolism ,Biomedical and clinical sciences ,Health sciences - Abstract
ObjectiveExperimental studies have implicated soluble (s)CD14, an effector of lipopolysaccharide-induced inflammation, in insulin resistance, but its role in human metabolic endotoxemia has not been studied. We evaluated sCD14 in relation to dysglycemia in older adults and how this compares to other markers of inflammation.Research design and methodsWe investigated associations of sCD14, interleukin-6 (IL-6), CRP, and white blood cell (WBC) count with insulin resistance (quantitative insulin-sensitivity check index and HOMA 2 of insulin resistance) and incident type 2 diabetes in a population-based cohort of older adults. We also assessed the causal role of sCD14 in insulin resistance using an instrumental variable approach by Mendelian randomization.ResultsAfter adjustment for conventional risk factors, each of the four biomarkers showed positive cross-sectional associations with both insulin resistance measures. These associations persisted after mutual adjustment for all markers except sCD14. Over a median follow-up of 11.6 years, 466 cases of diabetes occurred. All biomarkers except sCD14 were positively associated with diabetes, although only WBC count remained associated (hazard ratio 1.43 per doubling [95% CI 1.07, 1.90]) after mutual adjustment. Instrumental variable analysis did not support a causal role for sCD14 in insulin resistance.ConclusionsAmong older adults, sCD14 was associated with insulin resistance, but this disappeared after adjustment for other biomarkers, showed no evidence of a causal basis, and was not accompanied by a similar association with diabetes. IL-6, CRP, and WBC count were each associated with insulin resistance and diabetes, WBC count most robustly. These findings do not support a central role for sCD14, but they highlight the preeminence of WBC count as an inflammatory measure of diabetes risk in this population.
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- 2019
20. Association of dietary fatty acids with the risk of atherosclerotic cardiovascular disease in a prospective cohort of US Veterans
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Ivey, Kerry L., guyen, Xuan-Mai T.N., Li, Ruifeng, Furtado, Jeremy, Cho, Kelly, Gaziano, J. Michael, Hu, Frank B., Willett, Walter C., Wilson, Peter WF., and Djoussé, Luc
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- 2023
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21. Dietary ω-3 fatty acids and the incidence of atrial fibrillation in the Million Veteran Program
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Guardino, Eric T., Li, Yanping, Nguyen, Xuan-Mai, Wilson, Peter W.F., Gaziano, J. Michael, Cho, Kelly, Benjamin, Emelia J., and Djoussé, Luc
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- 2023
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22. Egg consumption and risk of acute stroke in the Million Veteran Program
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Al-Ramady, Omar, Latifi, Ahmad Nawid, Treu, Timothy, Ho, Yuk-Lam, Seshadri, Sudha, Aparicio, Hugo J., Cho, Kelly, Wilson, Peter WF., Gaziano, J. Michael, and Djoussé, Luc
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- 2022
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23. NT-proBNP and predictors of event free survival and left ventricular systolic function recovery in peripartum cardiomyopathy
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Imran, Tasnim F., Mohebali, Donya, Lopez, Diana, Goli, Rahul R., DeFilippis, Ersilia M., Truong, Sandy, Bello, Natalie A., Gaziano, J. Michael, Djousse, Luc, Coglianese, Erin E., Feinberg, Loryn, Wu, Wen-Chih, Choudhary, Gaurav, Arany, Zoltan, Kociol, Robb, and Sabe, Marwa A.
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- 2022
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24. Dairy product consumption and calcified atherosclerotic plaques in the coronary arteries: The NHLBI Family Heart Study
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Neisius, Ulf, Zhou, Guohai, Ward, Rachel E., Ellison, R. Curtis, Gaziano, J. Michael, and Djoussé, Luc
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- 2022
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25. Diabetes Mellitus, Race, and Effects of Omega-3 Fatty Acids on Incidence of Heart Failure Hospitalization
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Djoussé, Luc, Cook, Nancy R., Kim, Eunjung, Walter, Joseph, Al-Ramady, Omar T., Luttmann-Gibson, Heike, Albert, Christine M., Mora, Samia, Buring, Julie E., Gaziano, J. Michael, and Manson, JoAnn E.
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- 2022
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26. Alcohol Consumption and Risk of Coronary Artery Disease (from the Million Veteran Program)
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Song, Rebecca J, Nguyen, Xuan-Mai T, Quaden, Rachel, Ho, Yuk-Lam, Justice, Amy C, Gagnon, David R, Cho, Kelly, O'Donnell, Christopher J, Concato, John, Gaziano, J Michael, Djoussé, Luc, Program, VA Million Veteran, Halasz, Ildiko, Federman, Daniel, Beckham, Jean, Sherman, Scott E, Sriram, Peruvemba, Tsao, Philip S, Boyko, Edward J, Xu, Junzhe, Lederle, Frank, Dellitalia, Louis J, McArdle, Rachel, Kaminsky, Laurence, Swann, Alan C, Hamner, Mark B, Florez, Hermes J, Pandya, Prashant, Villarreal, Gerardo, Wilson, Peter, Morgan, Timothy R, Davis, Lori, Hurley, Robin A, Meyer, Laurence, Ahuja, Sunil K, Konicki, Eric P, Cohen, David, Lichy, Jack, Whittle, Jeffrey, Haddock, Kathlyn Sue, Straub, Karl D, Callaghan, John T, Aguayo, Samuel M, Gupta, Samir, Washburn, Ronald G, Oehlert, Mary E, Hung, Adriana M, Wallbom, Agnes, Keith, Robert, Sonel, Elif, Schifman, Ronald B, Childress, Richard D, Godschalk, Michael F, Shuldiner, Alan R, Rastogi, Padmashri, Gutierrez, Salvador, Fernando, Ronald, Iruvanti, Pran R, Jhala, Darshana, Rosado-Rodriguez, Carlos, Mastorides, Stephen M, Harley, John B, Mattocks, Kristin, Robey, Brooks, Striker, Robert T, Rauchman, Michael, Wells, John, Ballas, Zuhair K, Woods, Susan S, Yeh, Shing Shing, Ratcliffe, Nora R, Klein, Jon B, Golden, Adam G, Ginzburg, Harold M, Sharma, Satish, Oursler, Kris Ann K, Whooley, Mary A, Gibson, Gretchen, and Heinz
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Substance Misuse ,Brain Disorders ,Heart Disease - Coronary Heart Disease ,Alcoholism ,Alcohol Use and Health ,Heart Disease ,Cardiovascular ,Clinical Research ,Atherosclerosis ,Stroke ,Oral and gastrointestinal ,Good Health and Well Being ,Aged ,Alcohol Drinking ,Alcoholic Beverages ,Alcoholism ,Coronary Artery Disease ,Female ,Humans ,Male ,Middle Aged ,Proportional Hazards Models ,Protective Factors ,Risk Factors ,Self Report ,United States ,Veterans ,VA Million Veteran Program ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
Moderate alcohol consumption has been associated with a lower risk of coronary artery disease (CAD) in the general population but has not been well studied in US veterans. We obtained self-reported alcohol consumption from Million Veteran Program participants. Using electronic health records, CAD events were defined as 1 inpatient or 2 outpatient diagnosis codes for CAD, or 1 code for a coronary procedure. We excluded participants with prevalent CAD (n = 69,995) or incomplete alcohol information (n = 8,449). We used a Cox proportional hazards model to estimate hazard ratios and 95% confidence intervals for CAD, adjusting for age, gender, body mass index, race, smoking, education, and exercise. Among 156,728 participants, the mean age was 65.3 years (standard deviation = 12.1) and 91% were men. There were 6,153 CAD events during a mean follow-up of 2.9 years. Adjusted hazard ratios (95% confidence intervals) for CAD were 1.00 (reference), 1.02 (0.92 to 1.13), 0.83 (0.74 to 0.93), 0.77 (0.67 to 0.87), 0.71 (0.62 to 0.81), 0.62 (0.51 to 0.76), 0.58 (0.46 to 0.74), and 0.95 (0.85 to 1.06) for categories of never drinker; former drinker; current drinkers of ≤0.5 drink/day, >0.5 to 1 drink/day, >1 to 2 drinks/day, >2 to 3 drinks/day, and >3 to 4 drinks/day; and heavy drinkers (>4 drinks/day) or alcohol use disorder, respectively. For a fixed amount of ethanol, intake at ≥3 days/week was associated with lower CAD risk compared with ≤1 day/week. Beverage preference (beer, wine, or liquor) did not influence the alcohol-CAD relation. Our data show a lower risk of CAD with light-to-moderate alcohol consumption among US veterans, and drinking frequency may provide a further reduction in risk.
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- 2018
27. DASH Score and Subsequent Risk of Coronary Artery Disease: The Findings From Million Veteran Program
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Djoussé, Luc, Ho, Yuk‐Lam, Nguyen, Xuan‐Mai T, Gagnon, David R, Wilson, Peter WF, Cho, Kelly, Gaziano, J Michael, Program, the VA Million Veteran, Halasz, Ildiko, Federman, Daniel, Beckham, Jean, Sherman, Scott E, Sriram, Peruvemba, Tsao, Philip S, Boyko, Edward J, Xu, Junzhe, Lederle, Frank, Dellitalia, Louis J, McArdle, Rachel, Kaminsky, Laurence, Swann, Alan C, Hamner, Mark B, Florez, Hermes J, Pandya, Prashant, Villarreal, Gerardo, Wilson, Peter, Morgan, Timothy R, Davis, Lori, Hurley, Robin A, Meyer, Laurence, Ahuja, Sunil K, Konicki, Eric P, Cohen, David, Lichy, Jack, Whittle, Jeffrey, Haddock, Kathlyn Sue, Straub, Karl D, Callaghan, John T, Aguayo, Samuel M, Gupta, Samir, Washburn, Ronald G, Oehlert, Mary E, Hung, Adriana M, Wallbom, Agnes, Keith, Robert, Sonel, Elif, Schifman, Ronald B, Childress, Richard D, Godschalk, Michael F, Shuldiner, Alan R, Rastogi, Padmashri, Gutierrez, Salvador, Fernando, Ronald, Iruvanti, Pran R, Jhala, Darshana, Rosado‐Rodriguez, Carlos, Mastorides, Stephen M, Harley, John B, Mattocks, Kristin, Striker, Robert T, Rauchman, Michael, Wells, John, Ballas, Zuhair K, Woods, Susan S, Yeh, Shing, Ratcliffe, Nora R, Klein, Jon B, Golden, Adam G, Ginzburg, Harold M, Sharma, Satish, Oursler, Kris Ann K, Whooley, Mary A, and Gibson, Gretchen
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Nutrition ,Hypertension ,Atherosclerosis ,Clinical Research ,Cardiovascular ,Prevention ,Good Health and Well Being ,Aged ,Coronary Artery Disease ,Diet ,Healthy ,Dietary Approaches To Stop Hypertension ,Female ,Humans ,Incidence ,Male ,Middle Aged ,Patient Compliance ,Prognosis ,Prospective Studies ,Protective Factors ,Risk Assessment ,Risk Factors ,Risk Reduction Behavior ,Time Factors ,United States ,Veterans Health ,VA Million Veteran Program ,coronary artery disease ,epidemiology ,nutrition ,Cardiorespiratory Medicine and Haematology ,Cardiovascular medicine and haematology - Abstract
While adherence to healthful dietary patterns has been associated with a lower risk of coronary artery disease (CAD) in the general population, limited data are available among US veterans. We tested the hypothesis that adherence to Dietary Approach to Stop Hypertension (DASH) food pattern is associated with a lower risk of developing CAD among veterans. We analyzed data on 153 802 participants of the Million Veteran Program enrolled between 2011 and 2016. Information on dietary habits was obtained using a food frequency questionnaire at enrollment. We used electronic health records to assess the development of CAD during follow-up. Of the 153 802 veterans who provided information on diet and were free of CAD at baseline, the mean age was 64.0 (SD=11.8) years and 90.4% were men. During a mean follow-up of 2.8 years, 5451 CAD cases occurred. The crude incidence rate of CAD was 14.0, 13.1, 12.6, 12.3, and 11.1 cases per 1000 person-years across consecutive quintiles of Dietary Approach to Stop Hypertension score. Hazard ratios (95% confidence interval) for CAD were 1.0 (ref), 0.91 (0.84-0.99), 0.87 (0.80-0.95), 0.86 (0.79-0.94), and 0.80 (0.73-0.87) from the lowest to highest quintile of Dietary Approach to Stop Hypertension score controlling for age, sex, body mass index, race, smoking, exercise, alcohol intake, and statin use (P linear trend,
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- 2018
28. Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood
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Zheng, Yan, Huang, Tao, Wang, Tiange, Mei, Zhendong, Sun, Zhonghan, Zhang, Tao, Ellervik, Christina, Chai, Jin-Fang, Sim, Xueling, van Dam, Rob M., Tai, E-Shyong, Koh, Woon-Puay, Dorajoo, Rajkumar, Saw, Seang-Mei, Sabanayagam, Charumathi, Wong, Tien Yin, Gupta, Preeti, Rossing, Peter, Ahluwalia, Tarunveer S., Vinding, Rebecca K., Bisgaard, Hans, Bønnelykke, Klaus, Wang, Yujie, Graff, Mariaelisa, Voortman, Trudy, van Rooij, Frank J. A., Hofman, Albert, van Heemst, Diana, Noordam, Raymond, Estampador, Angela C., Varga, Tibor V., Enzenbach, Cornelia, Scholz, Markus, Thiery, Joachim, Burkhardt, Ralph, Orho-Melander, Marju, Schulz, Christina-Alexandra, Ericson, Ulrika, Sonestedt, Emily, Kubo, Michiaki, Akiyama, Masato, Zhou, Ang, Kilpeläinen, Tuomas O., Hansen, Torben, Kleber, Marcus E., Delgado, Graciela, McCarthy, Mark, Lemaitre, Rozenn N., Felix, Janine F., Jaddoe, Vincent W. V., Wu, Ying, Mohlke, Karen L., Lehtimäki, Terho, Wang, Carol A., Pennell, Craig E., Schunkert, Heribert, Kessler, Thorsten, Zeng, Lingyao, Willenborg, Christina, Peters, Annette, Lieb, Wolfgang, Grote, Veit, Rzehak, Peter, Koletzko, Berthold, Erdmann, Jeanette, Munz, Matthias, Wu, Tangchun, He, Meian, Yu, Caizheng, Lecoeur, Cécile, Froguel, Philippe, Corella, Dolores, Moreno, Luis A., Lai, Chao-Qiang, Pitkänen, Niina, Boreham, Colin A., Ridker, Paul M., Rosendaal, Frits R., de Mutsert, Renée, Power, Chris, Paternoster, Lavinia, Sørensen, Thorkild I. A., Tjønneland, Anne, Overvad, Kim, Djousse, Luc, Rivadeneira, Fernando, Lee, Nanette R., Raitakari, Olli T., Kähönen, Mika, Viikari, Jorma, Langhendries, Jean-Paul, Escribano, Joaquin, Verduci, Elvira, Dedoussis, George, König, Inke, Balkau, Beverley, Coltell, Oscar, Dallongeville, Jean, Meirhaeghe, Aline, Amouyel, Philippe, Gottrand, Frédéric, Pahkala, Katja, Niinikoski, Harri, Hyppönen, Elina, März, Winfried, Mackey, David A., Gruszfeld, Dariusz, Tucker, Katherine L., Fumeron, Frédéric, Estruch, Ramon, Ordovas, Jose M., Arnett, Donna K., Mook-Kanamori, Dennis O., Mozaffarian, Dariush, Psaty, Bruce M., North, Kari E., Chasman, Daniel I., and Qi, Lu
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- 2020
29. Dietary yogurt is distinct from other dairy foods in its association with circulating lipid profile: Findings from the Million Veteran Program
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Ivey, Kerry L., Nguyen, Xuan-Mai T., Tobias, Deirdre K., Song, Rebecca, Rogers, Geraint B., Ho, Yuk-Lam, Li, Ruifeng, Wilson, Peter WF., Cho, Kelly, Gaziano, J. Michael, Willett, Walter C., and Djoussé, Luc
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- 2021
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30. Consumption of potatoes and incidence rate of coronary artery disease: The Million Veteran Program
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Bodar, Vijaykumar, Ho, Yuk-Lam, Cho, Kelly, Gagnon, David, Gaziano, J. Michael, and Djoussé, Luc
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- 2021
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31. Nut consumption, risk of cardiovascular mortality, and potential mediating mechanisms: The Women's Health Study
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Imran, Tasnim F., Kim, Eunjung, Buring, Julie E., Lee, I-Min, Gaziano, J. Michael, and Djousse, Luc
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- 2021
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32. Detection of genetic loci associated with plasma fetuin-A: a meta-analysis of genome-wide association studies from the CHARGE Consortium
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Jensen, Majken K, Jensen, Richard A, Mukamal, Kenneth J, Guo, Xiuqing, Yao, Jie, Sun, Qi, Cornelis, Marilyn, Liu, Yongmei, Chen, Ming-Huei, Kizer, Jorge R, Djoussé, Luc, Siscovick, David S, Psaty, Bruce M, Zmuda, Joseph M, Rotter, Jerome I, Garcia, Melissa, Harris, Tamara, Chen, Ida, Goodarzi, Mark O, Nalls, Michael A, Keller, Margaux, Arnold, Alice M, Newman, Anne B, Hoogeveen, Ron C, Rexrode, Kathryn M, Rimm, Eric B, Hu, Frank B, Ramachandran, Vasan S, Katz, Ronit, Pankow, James S, and Ix, Joachim H
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Human Genome ,Genetics ,Aetiology ,2.1 Biological and endogenous factors ,Metabolic and endocrine ,Adult ,Black or African American ,Aged ,Diabetes Mellitus ,Type 2 ,Female ,Genetic Loci ,Genome-Wide Association Study ,Genotype ,Humans ,Male ,Metabolic Syndrome ,Middle Aged ,Polymorphism ,Single Nucleotide ,White People ,alpha-2-HS-Glycoprotein ,Biological Sciences ,Medical and Health Sciences ,Genetics & Heredity - Abstract
Plasma fetuin-A is associated with type 2 diabetes, and AHSG, the gene encoding fetuin-A, has been identified as a susceptibility locus for diabetes and metabolic syndrome. Thus far, unbiased investigations of the genetic determinants of plasma fetuin-A concentrations have not been conducted. We searched for single nucleotide polymorphisms (SNPs) related to fetuin-A concentrations by a genome-wide association study in six population-based studies. We examined the association of fetuin-A levels with ∼ 2.5 million genotyped and imputed SNPs in 9,055 participants of European descent and 2,119 African Americans. In both ethnicities, the strongest associations were centered in a region with a high degree of LD near the AHSG locus. Among 136 genome-wide significant (P
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- 2017
33. Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study
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Ahiawodzi, Peter D, Kerber, Richard A, Taylor, Kira C, Groves, Frank D, O'Brien, Elizabeth, Ix, Joachim H, Kizer, Jorge R, Djoussé, Luc, Tracy, Russell P, Newman, Anne B, Siscovick, David S, Robbins, John, and Mukamal, Kenneth
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Aging ,Sleep Research ,Cardiovascular ,Lung ,Good Health and Well Being ,Aged ,Aged ,80 and over ,Cardiovascular Diseases ,Case-Control Studies ,Female ,Humans ,Lysine ,Male ,Oxidative Stress ,Sex Factors ,Sleep Apnea Syndromes ,Carboxymethyl-lysine ,advanced glycation end-product ,sleep-disordered breathing ,oxidative stress ,Apnea-Hypopnea Index ,Apnea–Hypopnea Index ,Environmental Biotechnology ,Toxicology ,Bioinformatics and computational biology ,Medical biotechnology ,Environmental biotechnology - Abstract
ContextCarboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease.ObjectiveThe objective of this study is to investigate the association between sleep-disordered breathing (SDB) - a source of oxidative stress - and CML.Materials and methodsAbout 1002 participants in the Cardiovascular Health Study (CHS) were studied.ResultsWomen with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03-2.58, p = 0.04). The association was not significant among men.DiscussionSDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study.ConclusionAccumulation of CML may be an adverse health consequence of SDB.
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- 2017
34. Non-esterified fatty acids and telomere length in older adults: The Cardiovascular Health Study
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Ahiawodzi, Peter, Fitzpatrick, Annette L., Djousse, Luc, Ix, Joachim H., Kizer, Jorge R., and Mukamal, Kenneth J.
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- 2020
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35. Coffee consumption and risk of heart failure in the Physicians' Health Study
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Bodar, Vijaykumar, Chen, Jiaying, Sesso, Howard D., Gaziano, J. Michael, and Djoussé, Luc
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- 2020
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36. Circulating sphingolipids and subclinical brain pathology: the cardiovascular health study.
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Moseholm, Kristine F., Horn, Jens W., Fitzpatrick, Annette L., Djoussé, Luc, Longstreth Jr., W. T., Lopez, Oscar L., Hoofnagle, Andrew N., Jensen, Majken K., Lemaitre, Rozenn N., and Mukamal, Kenneth J.
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BRAIN diseases ,SPHINGOLIPIDS ,GLIAL fibrillary acidic protein ,MAGNETIC resonance imaging ,WHITE matter (Nerve tissue) - Abstract
Background: Sphingolipids are implicated in neurodegeneration and neuroinflammation. We assessed the potential role of circulating ceramides and sphingomyelins in subclinical brain pathology by investigating their association with brain magnetic resonance imaging (MRI) measures and circulating biomarkers of brain injury, neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in the Cardiovascular Health Study (CHS), a large and intensively phenotyped cohort of older adults. Methods: Brain MRI was offered twice to CHS participants with a mean of 5 years between scans, and results were available from both time points in 2,116 participants (mean age 76 years; 40% male; and 25% APOE ε4 allele carriers). We measured 8 ceramide and sphingomyelin species in plasma samples and examined the associations with several MRI, including worsening grades of white matter hyperintensities and ventricular size, number of brain infarcts, and measures of brain atrophy in a subset with quantitative measures. We also investigated the sphingolipid associations with serum NfL and GFAP. Results: In the fully adjusted model, higher plasma levels of ceramides and sphingomyelins with a long (16-carbon) saturated fatty acid were associated with higher blood levels of NfL [β = 0.05, false-discovery rate corrected P (PFDR) = 0.004 and β = 0.06, P
FDR = < 0.001, respectively]. In contrast, sphingomyelins with very long (20- and 22-carbon) saturated fatty acids tended to have an inverse association with levels of circulating NfL. In secondary analyses, we found an interaction between ceramide d18:1/20:0 and sex (P for interaction = <0.001), such that ceramide d18:1/20:0 associated with higher odds for infarcts in women [OR = 1.26 (95%CI: 1.07, 1.49), PFDR = 0.03]. We did not observe any associations with GFAP blood levels, white matter grade, ventricular grade, mean bilateral hippocampal volume, or total brain volume. Conclusion: Overall, our comprehensive investigation supports the evidence that ceramides and sphingomyelins are associated with increased aging brain pathology and that the direction of association depends on the fatty acid attached to the sphingosine backbone. [ABSTRACT FROM AUTHOR]- Published
- 2024
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37. Statins, Mortality, and Major Adverse Cardiovascular Events Among US Veterans With Chronic Kidney Disease
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Barayev, Odeya, primary, Hawley, Chelsea E., additional, Wellman, Helen, additional, Gerlovin, Hanna, additional, Hsu, Whitney, additional, Paik, Julie M., additional, Mandel, Ernest I., additional, Liu, Christine K., additional, Djoussé, Luc, additional, Gaziano, J. Michael, additional, Gagnon, David R., additional, and Orkaby, Ariela R., additional
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- 2023
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38. Genome‐wide Association Study Meta‐analysis of Neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration
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Ahmad, Shahzad, primary, Imtiaz, Mohammed Aslam, additional, Mishra, Aniket, additional, Wang, Ruiqi, additional, Rivero, Marisol Herrera‐, additional, Bis, Joshua C, additional, Fornage, Myriam, additional, Roshchupkin, Gennady V., additional, Hofer, Edith, additional, Logue, Mark W., additional, Longstreth, W.T., additional, Xia, Rui, additional, Bouteloup, Vincent, additional, Mosley, Thomas H., additional, Launer, Lenore J J., additional, Khalil, Michael, additional, Kuhle, Jens, additional, Rissman, Robert A, additional, Chêne, Geneviève, additional, Dufouil, Carole, additional, Djoussé, Luc, additional, Lyons, Michael J., additional, Mukamal, Kenneth J, additional, Stone, William Seth, additional, Franz, Carol E, additional, Schmidt, Reinhold, additional, Debette, Stéphanie, additional, Breteler, Monique M.B., additional, Berger, Klaus, additional, Yang, Qiong, additional, Seshadri, Sudha, additional, Aziz, N. Ahmad, additional, Ghanbari, Mohsen, additional, and Ikram, M. Arfan, additional
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- 2023
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39. Serum Nf‐L and GFAP are associated with incident dementia and dementia mortality in older adults: The Cardiovascular Health Study
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Cronjé, Héléne Toinét, primary, Liu, Xiaojuan, additional, Odden, Michelle, additional, Moseholm, Kristine F, additional, Seshadri, Sudha, additional, Satizabal, Claudia L., additional, Lopez, Oscar L., additional, Bis, Joshua C, additional, Djoussé, Luc, additional, Fohner, Alison E, additional, Psaty, Bruce M., additional, Tracy, Russell P., additional, Longstreth, W.T., additional, Jensen, Majken K, additional, and Mukamal, Kenneth J, additional
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- 2023
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40. Association of dietary fatty acids with the risk of atherosclerotic cardiovascular disease in a prospective cohort of United States veterans
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Ivey, Kerry L., primary, Nguyen, Xuan-Mai T., additional, Li, Ruifeng, additional, Furtado, Jeremy, additional, Cho, Kelly, additional, Gaziano, John Michael, additional, Hu, Frank B., additional, Willett, Walter C., additional, Wilson, Peter WF., additional, and Djoussé, Luc, additional
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- 2023
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41. Sleep Disturbances and Glucose Metabolism in Older Adults: The Cardiovascular Health Study
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Strand, Linn Beate, Carnethon, Mercedes, Biggs, Mary Lou, Djoussé, Luc, Kaplan, Robert C, Siscovick, David S, Robbins, John A, Redline, Susan, Patel, Sanjay R, Janszky, Imre, and Mukamal, Kenneth J
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Lung ,Diabetes ,Sleep Research ,Nutrition ,Prevention ,Aging ,Cardiovascular ,Metabolic and endocrine ,Adult ,Aged ,Blood Glucose ,Cardiovascular System ,Cross-Sectional Studies ,Diabetes Mellitus ,Type 2 ,Fasting ,Female ,Glucose Tolerance Test ,Humans ,Incidence ,Insulin ,Insulin Resistance ,Male ,Middle Aged ,Sleep Apnea Syndromes ,Sleep Initiation and Maintenance Disorders ,Snoring ,United States ,Medical and Health Sciences ,Endocrinology & Metabolism ,Biomedical and clinical sciences ,Health sciences - Abstract
ObjectiveWe examined the associations of symptoms of sleep-disordered breathing (SDB), which was defined as loud snoring, stopping breathing for a while during sleep, and daytime sleepiness, and insomnia with glucose metabolism and incident type 2 diabetes in older adults.Research design and methodsBetween 1989 and 1993, the Cardiovascular Health Study recruited 5,888 participants ≥65 years of age from four U.S. communities. Participants reported SDB and insomnia symptoms yearly through 1989-1994. In 1989-1990, participants underwent an oral glucose tolerance test, from which insulin secretion and insulin sensitivity were estimated. Fasting glucose levels were measured in 1989-1990 and again in 1992-1993, 1994-1995, 1996-1997, and 1998-1999, and medication use was ascertained yearly. We determined the cross-sectional associations of sleep symptoms with fasting glucose levels, 2-h glucose levels, insulin sensitivity, and insulin secretion using generalized estimated equations and linear regression models. We determined the associations of updated and averaged sleep symptoms with incident diabetes in Cox proportional hazards models. We adjusted for sociodemographics, lifestyle factors, and medical history.ResultsObserved apnea, snoring, and daytime sleepiness were associated with higher fasting glucose levels, higher 2-h glucose levels, lower insulin sensitivity, and higher insulin secretion. The risk of the development of type 2 diabetes was positively associated with observed apnea (hazard ratio [HR] 1.84 [95% CI 1.19-2.86]), snoring (HR 1.27 [95% CI 0.95-1.71]), and daytime sleepiness (HR 1.54 [95% CI 1.13-2.12]). In contrast, we did not find consistent associations between insomnia symptoms and glucose metabolism or incident type 2 diabetes.ConclusionsEasily collected symptoms of SDB are strongly associated with insulin resistance and the incidence of type 2 diabetes in older adults. Monitoring glucose metabolism in such patients may prove useful in identifying candidates for lifestyle or pharmacological therapy. Further studies are needed to determine whether insomnia symptoms affect the risk of diabetes in younger adults.
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- 2015
42. Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians 1 , 2
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Fretts, Amanda M, Follis, Jack L, Nettleton, Jennifer A, Lemaitre, Rozenn N, Ngwa, Julius S, Wojczynski, Mary K, Kalafati, Ioanna Panagiota, Varga, Tibor V, Frazier-Wood, Alexis C, Houston, Denise K, Lahti, Jari, Ericson, Ulrika, van den Hooven, Edith H, Mikkilä, Vera, Kiefte-de Jong, Jessica C, Mozaffarian, Dariush, Rice, Kenneth, Renström, Frida, North, Kari E, McKeown, Nicola M, Feitosa, Mary F, Kanoni, Stavroula, Smith, Caren E, Garcia, Melissa E, Tiainen, Anna-Maija, Sonestedt, Emily, Manichaikul, Ani, van Rooij, Frank JA, Dimitriou, Maria, Raitakari, Olli, Pankow, James S, Djoussé, Luc, Province, Michael A, Hu, Frank B, Lai, Chao-Qiang, Keller, Margaux F, Perälä, Mia-Maria, Rotter, Jerome I, Hofman, Albert, Graff, Misa, Kähönen, Mika, Mukamal, Kenneth, Johansson, Ingegerd, Ordovas, Jose M, Liu, Yongmei, Männistö, Satu, Uitterlinden, André G, Deloukas, Panos, Seppälä, Ilkka, Psaty, Bruce M, Cupples, L Adrienne, Borecki, Ingrid B, Franks, Paul W, Arnett, Donna K, Nalls, Mike A, Eriksson, Johan G, Orho-Melander, Marju, Franco, Oscar H, Lehtimäki, Terho, Dedoussis, George V, Meigs, James B, and Siscovick, David S
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Prevention ,Diabetes ,Genetics ,Aging ,Cardiovascular ,Nutrition ,Metabolic and endocrine ,Blood Glucose ,Cohort Studies ,Genetic Association Studies ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Hyperglycemia ,Hyperinsulinism ,Insulin ,Insulin Resistance ,Insulin Secretion ,Insulin-Secreting Cells ,Meat ,Meat Products ,Middle Aged ,Polymorphism ,Single Nucleotide ,Risk Factors ,diet ,gene–diet interaction ,glucose ,insulin ,meat intake ,meta-analysis ,Engineering ,Medical and Health Sciences ,Nutrition & Dietetics ,Clinical sciences ,Nutrition and dietetics - Abstract
BackgroundRecent studies suggest that meat intake is associated with diabetes-related phenotypes. However, whether the associations of meat intake and glucose and insulin homeostasis are modified by genes related to glucose and insulin is unknown.ObjectiveWe investigated the associations of meat intake and the interaction of meat with genotype on fasting glucose and insulin concentrations in Caucasians free of diabetes mellitus.DesignFourteen studies that are part of the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium participated in the analysis. Data were provided for up to 50,345 participants. Using linear regression within studies and a fixed-effects meta-analysis across studies, we examined 1) the associations of processed meat and unprocessed red meat intake with fasting glucose and insulin concentrations; and 2) the interactions of processed meat and unprocessed red meat with genetic risk score related to fasting glucose or insulin resistance on fasting glucose and insulin concentrations.ResultsProcessed meat was associated with higher fasting glucose, and unprocessed red meat was associated with both higher fasting glucose and fasting insulin concentrations after adjustment for potential confounders [not including body mass index (BMI)]. For every additional 50-g serving of processed meat per day, fasting glucose was 0.021 mmol/L (95% CI: 0.011, 0.030 mmol/L) higher. Every additional 100-g serving of unprocessed red meat per day was associated with a 0.037-mmol/L (95% CI: 0.023, 0.051-mmol/L) higher fasting glucose concentration and a 0.049-ln-pmol/L (95% CI: 0.035, 0.063-ln-pmol/L) higher fasting insulin concentration. After additional adjustment for BMI, observed associations were attenuated and no longer statistically significant. The association of processed meat and fasting insulin did not reach statistical significance after correction for multiple comparisons. Observed associations were not modified by genetic loci known to influence fasting glucose or insulin resistance.ConclusionThe association of higher fasting glucose and insulin concentrations with meat consumption was not modified by an index of glucose- and insulin-related single-nucleotide polymorphisms. Six of the participating studies are registered at clinicaltrials.gov as NCT0000513 (Atherosclerosis Risk in Communities), NCT00149435 (Cardiovascular Health Study), NCT00005136 (Family Heart Study), NCT00005121 (Framingham Heart Study), NCT00083369 (Genetics of Lipid Lowering Drugs and Diet Network), and NCT00005487 (Multi-Ethnic Study of Atherosclerosis).
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- 2015
43. Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies
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Harris, William S., Tintle, Nathan L., Imamura, Fumiaki, Qian, Frank, Korat, Andres V. Ardisson, Marklund, Matti, Djoussé, Luc, Bassett, Julie K., Carmichael, Pierre-Hugues, Chen, Yun-Yu, Hirakawa, Yoichiro, Küpers, Leanne K., Laguzzi, Federica, Lankinen, Maria, Murphy, Rachel A., Samieri, Cécilia, Senn, Mackenzie K., Shi, Peilin, Virtanen, Jyrki K., Brouwer, Ingeborg A., Chien, Kuo-Liong, Eiriksdottir, Gudny, Forouhi, Nita G., Geleijnse, Johanna M., Giles, Graham G., Gudnason, Vilmundur, Helmer, Catherine, Hodge, Allison, Jackson, Rebecca, Khaw, Kay-Tee, Laakso, Markku, Lai, Heidi, Laurin, Danielle, Leander, Karin, Lindsay, Joan, Micha, Renata, Mursu, Jaako, Ninomiya, Toshiharu, Post, Wendy, Psaty, Bruce M., Risérus, Ulf, Robinson, Jennifer G., Shadyab, Aladdin H., Snetselaar, Linda, Sala-Vila, Aleix, Sun, Yangbo, Steffen, Lyn M., Tsai, Michael Y., Wareham, Nicholas J., Wood, Alexis C., Wu, Jason H. Y., Hu, Frank, Sun, Qi, Siscovick, David S., Lemaitre, Rozenn N., and Mozaffarian, Dariush
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- 2021
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44. Walking pace is inversely associated with risk of death and cardiovascular disease: The Physicians’ Health Study
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Imran, Tasnim F., Orkaby, Ariela, Chen, Jiaying, Selvaraj, Senthil, Driver, Jane A., Gaziano, J. Michael, and Djoussé, Luc
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- 2019
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45. Consumption of fried foods and risk of atrial fibrillation in the Physicians' Health Study
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Khawaja, Owais, Sesso, Howard D., Chen, Jiaying, Yamasaki, Hiroshi, Hassan, Sohail A., Gaziano, John M., and Djoussé, Luc
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- 2020
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46. Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta‐analysis of nine studies in the CHARGE consortium
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Smith, Caren E, Follis, Jack L, Nettleton, Jennifer A, Foy, Millennia, Wu, Jason HY, Ma, Yiyi, Tanaka, Toshiko, Manichakul, Ani W, Wu, Hongyu, Chu, Audrey Y, Steffen, Lyn M, Fornage, Myriam, Mozaffarian, Dariush, Kabagambe, Edmond K, Ferruci, Luigi, Chen, Yii-Der Ida, Rich, Stephen S, Djoussé, Luc, Ridker, Paul M, Tang, Weihong, McKnight, Barbara, Tsai, Michael Y, Bandinelli, Stefania, Rotter, Jerome I, Hu, Frank B, Chasman, Daniel I, Psaty, Bruce M, Arnett, Donna K, King, Irena B, Sun, Qi, Wang, Lu, Lumley, Thomas, Chiuve, Stephanie E, Siscovick, David S, Ordovás, José M, and Lemaitre, Rozenn N
- Subjects
Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Prevention ,Complementary and Integrative Health ,Nutrition ,Genetics ,Acetyltransferases ,Acyltransferases ,Adaptor Proteins ,Signal Transducing ,Carboxy-Lyases ,Delta-5 Fatty Acid Desaturase ,Diet ,Docosahexaenoic Acids ,Eicosapentaenoic Acid ,Erythrocyte Membrane ,Fatty Acid Desaturases ,Fatty Acid Elongases ,Fatty Acids ,Fatty Acids ,Omega-3 ,Female ,Humans ,Male ,Middle Aged ,Polymorphism ,Single Nucleotide ,FADS1 ,Gene-diet interactions ,Meta-analysis ,Omega-3 fatty acids ,Food Sciences ,Public Health and Health Services ,Food Science ,Nutrition & Dietetics ,Food sciences ,Nutrition and dietetics - Abstract
ScopeTissue concentrations of omega-3 fatty acids may reduce cardiovascular disease risk, and genetic variants are associated with circulating fatty acids concentrations. Whether dietary fatty acids interact with genetic variants to modify circulating omega-3 fatty acids is unclear. We evaluated interactions between genetic variants and fatty acid intakes for circulating alpha-linoleic acid, eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid.Methods and resultsWe conducted meta-analyses (N = 11 668) evaluating interactions between dietary fatty acids and genetic variants (rs174538 and rs174548 in FADS1 (fatty acid desaturase 1), rs7435 in AGPAT3 (1-acyl-sn-glycerol-3-phosphate), rs4985167 in PDXDC1 (pyridoxal-dependent decarboxylase domain-containing 1), rs780094 in GCKR (glucokinase regulatory protein), and rs3734398 in ELOVL2 (fatty acid elongase 2)). Stratification by measurement compartment (plasma versus erthyrocyte) revealed compartment-specific interactions between FADS1 rs174538 and rs174548 and dietary alpha-linolenic acid and linoleic acid for docosahexaenoic acid and docosapentaenoic acid.ConclusionOur findings reinforce earlier reports that genetically based differences in circulating fatty acids may be partially due to differences in the conversion of fatty acid precursors. Further, fatty acids measurement compartment may modify gene-diet relationships, and considering compartment may improve the detection of gene-fatty acids interactions for circulating fatty acid outcomes.
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- 2015
47. Metabolic Syndrome and Risk of Incident Peripheral Artery Disease
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Garg, Parveen K, Biggs, Mary L, Carnethon, Mercedes, Ix, Joachim H, Criqui, Michael H, Britton, Kathryn A, Djoussé, Luc, Sutton-Tyrrell, Kim, Newman, Anne B, Cushman, Mary, and Mukamal, Kenneth J
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Aging ,Cardiovascular ,Clinical Research ,Prevention ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Aged ,Ankle Brachial Index ,C-Reactive Protein ,Female ,Fibrinogen ,Follow-Up Studies ,Humans ,Incidence ,Longitudinal Studies ,Male ,Metabolic Syndrome ,Peripheral Arterial Disease ,Prevalence ,Risk Factors ,Vasculitis ,cohort studies ,inflammation ,metabolic syndrome ,peripheral artery disease ,Cardiorespiratory Medicine and Haematology ,Public Health and Health Services ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
Prior studies evaluating metabolic syndrome (MetS) and incident peripheral artery disease (PAD) have been limited by use of modified MetS criteria and restriction to clinical PAD end points. We investigated MetS and risk of developing a low ankle-brachial index (ABI) and clinical PAD in the Cardiovascular Health Study, a population-based cohort of adults aged ≥65 years. Participants with MetS met at least 3 of 5 Adult Treatment Panel III criteria. Baseline C-reactive protein-MetS or fibrinogen-MetS were defined as presence of 3 of 6 components, with elevated C-reactive protein (>3 mg/L) or fibrinogen (>341 mg/dL) as a sixth component. Incident low ABI, defined as ABI
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- 2014
48. Nut Consumption and Cardiovascular Disease
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Imran, Tasnim F., primary and Djoussé, Luc, additional
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- 2020
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49. Prevalence of Ideal Cardiovascular Health Metrics in the Million Veteran Program
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Nguyen, Xuan-Mai T., Quaden, Rachel M., Wolfrum, Sarah, Song, Rebecca J., Yan, Joseph Q., Gagnon, David R., Wilson, Peter W.F., Cho, Kelly, O'Donnell, Christopher, Gaziano, J. Michael, and Djousse, Luc
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- 2018
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50. Alcohol Consumption and Risk of Coronary Artery Disease (from the Million Veteran Program)
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Halasz, Ildiko, Federman, Daniel, Beckham, Jean, Sherman, Scott E., Sriram, Peruvemba, Tsao, Philip S., Boyko, Edward J., Xu, Junzhe, Lederle, Frank, Dellitalia, Louis J., McArdle, Rachel, Kaminsky, Laurence, Swann, Alan C., Hamner, Mark B., Florez, Hermes J., Pandya, Prashant, Villarreal, Gerardo, Wilson, Peter, Morgan, Timothy R., Davis, Lori, Hurley, Robin A., Meyer, Laurence, Ahuja, Sunil K., Konicki, Eric P., Cohen, David, Lichy, Jack, Whittle, Jeffrey, Haddock, Kathlyn Sue, Straub, Karl D., Callaghan, John T., Aguayo, Samuel M., Gupta, Samir, Washburn, Ronald G., Oehlert, Mary E., Hung, Adriana M., Wallbom, Agnes, Keith, Robert, Sonel, Elif, Schifman, Ronald B., Childress, Richard D., Godschalk, Michael F., Shuldiner, Alan R., Rastogi, Padmashri, Gutierrez, Salvador, Fernando, Ronald, Iruvanti, Pran R., Jhala, Darshana, Rosado-Rodriguez, Carlos, Mastorides, Stephen M., Harley, John B., Mattocks, Kristin, Robey, Brooks, Striker, Robert T., Rauchman, Michael, Wells, John, Ballas, Zuhair K., Woods, Susan S., Yeh, Shing Shing, Ratcliffe, Nora R., Klein, Jon B., Golden, Adam G., Ginzburg, Harold M., Sharma, Satish, Oursler, Kris Ann K., Whooley, Mary A., Gibson, Gretchen, Heinz, Song, Rebecca J., Nguyen, Xuan-Mai T., Quaden, Rachel, Ho, Yuk-Lam, Justice, Amy C., Gagnon, David R., Cho, Kelly, O'Donnell, Christopher J., Concato, John, Gaziano, J. Michael, and Djoussé, Luc
- Published
- 2018
- Full Text
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