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This article presents the results of the statistical modeling of copper losses in the silicate slag of the sulfide concentrates smelting process. The aim of this study was to define the correlation dependence of the degree of copper losses in the silicate slag on the following parameters of technological processes: SiO2, FeO, Fe3O4, CaO and Al2O3 content in the slag and copper content in the matte. Multiple linear regression analysis (MLRA), artificial neural networks (ANNs) and adaptive network based fuzzy inference system (ANFIS) were used as tools for mathematical analysis of the indicated problem. The best correlation coefficient (R2 = 0.719) of the final model was obtained using the ANFIS modeling approach.

Objective: To compare the effect of glucose-lowering drugs on peripheral nerve and kidney function in prediabetes. Methods: Multicenter, randomized, placebo-controlled trial in 658 adults with prediabetes treated for 1 year with metformin, linagliptin, their combination or placebo. Endpoints are small fiber peripheral neuropathy (SFPN) risk estimated by foot electrochemical skin conductance (FESC < 70 μSiemens) and estimated glomerular filtration rate (eGFR). Results: Compared to the placebo, the proportion of SFPN was reduced by 25.1% (95% CI:16.3–33.9) with metformin alone, by 17.3% (95% CI 7.4–27.2) with linagliptin alone, and by 19.5% (95% CI 10.1–29.0) with the combination linagliptin/metformin (p < 0.0001 for all comparisons). eGFR remained +3.3 mL/min (95% CI: 0.38–6.22) higher with the combination linagliptin/metformin than with the placebo (p = 0.03). Fasting plasma glucose (FPG) decreased more with metformin monotherapy −0.3 mmol/L (95%CI: −0.48; 0.12, p = 0.0009) and with the combination metformin/linagliptin −0.2 mmol/L (95% CI: −0.37; −0.03) than with the placebo (p = 0.0219). Body weight (BW) decreased by −2.0 kg (95% CI: −5.65; −1.65, p = 0.0006) with metformin monotherapy, and by −1.9 kg (95% CI: −3.02; −0.97) with the combination metformin/linagliptin as compared to the placebo (p = 0.0002). Conclusions: in people with prediabetes, a 1 year treatment with metformin and linagliptin, combined or in monotherapy, was associated with a lower risk of SFPN, and with a lower decrease in eGFR, than treatment with placebo. [ABSTRACT FROM AUTHOR]

Objectives: To assess the effects of early management of hyperglycaemia with antidiabetic drugs plus lifestyle intervention compared with lifestyle alone, on microvascular function in adults with pre-diabetes. Methods: Trial design: International, multicenter, randomised, partially double-blind, placebo-controlled, clinical trial. Participants: Males and females aged 45–74 years with IFG, IGT or IFG+IGT, recruited from primary care centres in Australia, Austria, Bulgaria, Greece, Kuwait, Poland, Serbia, Spain and Turkey. Intervention: Participants were randomized to placebo; metformin 1.700 mg/day; linagliptin 5 mg/day or fixed-dose combination of linagliptin/metformin. All patients were enrolled in a lifestyle intervention program (diet and physical activity). Drug intervention will last 2 years. Primary Outcome: composite end-point of diabetic retinopathy estimated by the Early Treatment Diabetic Retinopathy Study Score, urinary albumin to creatinine ratio, and skin conductance in feet estimated by the sudomotor index. Secondary outcomes in a subsample include insulin sensitivity, beta-cell function, biomarkers of inflammation and fatty liver disease, quality of life, cognitive function, depressive symptoms and endothelial function. Results: One thousand three hundred ninety one individuals with hyperglycaemia were assessed for eligibility, 424 excluded after screening, 967 allocated to placebo, metformin, linagliptin or to fixed-dose combination of metformin + linagliptin. A total of 809 people (91.1%) accepted and initiated the assigned treatment. Study sample after randomization was well balanced among the four groups. No statistical differences for the main risk factors analysed were observed between those accepting or rejecting treatment initiation. At baseline prevalence of diabetic retinopathy was 4.2%, severe neuropathy 5.3% and nephropathy 5.7%. Conclusions: ePREDICE is the first -randomized clinical trial with the aim to assess effects of different interventions (lifestyle and pharmacological) on microvascular function in people with pre-diabetes. The trial will provide novel data on lifestyle modification combined with glucose lowering drugs for the prevention of early microvascular complications and diabetes. Registration: - ClinicalTrials.Gov Identifier: NCT03222765 - EUDRACT Registry Number: 2013-000418-39 [ABSTRACT FROM AUTHOR]

This paper presents the results of an empirical investigation of the impact of leadership on strategy of quality planning in manufacturing companies with a certified Quality Management System (QMS) according to the requirements of ISO 9001, in the southern Serbia. Theoretical structural model and hypothesis of the impact of leadership on the elements of strategy of quality planning were defined. Path coefficients in the structural model were determined using LISLER v.16 software, which proved the defined hypothesis, except the hypothesis regarding customers and suppliers involvement in quality planning. Based on the results of the empirical research performed in this paper it is shown that under the conditions of transitional economy, under which Serbian companies have been operating for over two decades, QMS certification according to the requirements of ISO 9001 has been conducted pro forma and it does not function according to the guidelines of this standard within the suppliers – company – customers supply chain. [ABSTRACT FROM AUTHOR]

In this paper, a model for the development of relationships with suppliers in order to create long-term partnerships, while following the requirements of ISO 9001 standard, was defined. Research has shown that the same relations with suppliers that exist between standardised companies (SC) and non-standardised companies (NSC) within the set of suppliers, also exist between NSC and NSC within the set of companies. Creating partnerships between SC and NSC suppliers is not possible, while obtained results show the opposite, which clearly indicates that the certification in the studied economy is being performed pro forma. [ABSTRACT FROM PUBLISHER]

The formation of input batch zinc concentrates is one of the key processes on which the quality and efficiency of all subsequent operations during the production of zinc cathodes directly depends. The optimization of the formation of a mixed batch aims at making a selection between the zinc concentrates that have different contents of useful and harmful components and to determine their share in the optimal mix. A multi criteria optimization model, which can be a good support for the defined problem of determining the optimal mixture of zinc concentrates, was developed in this study. For an evaluation of this model, according to four different research scenarios, the PROMETHEE/GAIA methodology was used to rank the considered zinc concentrates and determine their optimal share in the mix batch. In addition, the determination of the significance of the criteria in the optimization model was performed by application of the subjective AHP approach and the objective entropic approach. The results of this study, which were obtained during an analysis of a real case from the practice of a zinc production facility, indicate that the choice and formation of the optimal mixture of concentrates directly depends on the subjective or objective type of assessment of the significance of several chemical components in the zinc concentrates, and on the market price of the considered concentrates. [ABSTRACT FROM PUBLISHER]

This paper presents the results of investigation of the effect of slag composition and the slag basicity, in the process of smelting of sulfide copper concentrate, on the distribution coefficient () for the following elements: Cu, Bi, Co, Au, Ag, Zn, Pb, Ni, As, Sb, Se, and Te. The research was conducted under the industrial operating conditions of the copper smelter in Bor, Serbia. High values for the coefficient of determination (R2 > 0.6) for thedependence on the slag composition were obtained, which presents a high degree of fitting. In the case of the dependence ofon the slag basicity, obtainedR2values were much lower, due to the much smaller statistical sample. [ABSTRACT FROM AUTHOR]

Abstract: This paper presents the extremely high concentrations of SO2 and particulate matter measured in the urban area of the town Bor (Serbia) during August 2011. Concentrations of SO2 above 125μgm−3 and concentrations of particulate matter above 200μgm−3 recorded over several days indicate significant risk to human health and the ecosystem in this region. [Copyright &y& Elsevier]

Paraneoplastic syndrome might be the first clinical manifestation of malignancy. We present a menopausal female with the acquired hypertrichosis lanuginosa (AHL) as an initial clinical presentation of rectal adenocarcinoma, unusually associated with paraneoplastic cerebellar degeneration (PCD) and disseminated intravascular coagulation (DIC). [ABSTRACT FROM AUTHOR]

Backgrounds/aims: The aim of this study was to compare efficacy of two enzymes, Liberase HI and Collagenase XI in human adult pancreatic islet isolation., Methodology: Pancreatic tissue samples were digested either with Liberase HI or Collagenase XI, using a non-automated method. We investigated the effect of both enzymes on yield, function and percent viability of the islets., Results: No significant differences were found regarding islet yield when comparing Liberase HI to Collagenase XI. Viability of Collagenase-isolated islets was initially lower, but following 3 days of culture they attained a higher viability than the Liberase treated islets. Although the stimulation index tended to be higher in the Liberase-isolated islets no significant differences were observed between the two enzymes, except on the first day of cultivation; SI values for all Liberase concentrations were significantly higher than for Collagenase (p < 0.05)., Conclusions: We conclude that during the isolation procedure using Collagenase XI, the functional capacity of the isolated islets decline, but this is restored during a subsequent cultivation. On the other hand, during digestion with Liberase HI, the islets suffer less functional damage, resulting in better preservation of their functional capacity immediately after the isolation, as well as the subsequent 7 days of cultivation.