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18. DHA-enriched fish oil upregulates cyclin-dependent kinase inhibitor 2A (P16INK) expression and downregulates telomerase activity without modulating effects of PPARγ Pro12Ala polymorphism in type 2 diabetic patients: A randomized, double-blind, placebo-controlled clinical trial

Author

Toupchian, Omid, Sotoudeh, Gity, Mansoori, Anahita, Abdollahi, Shima, Ali Keshavarz, Seyyed, Djalali, Mahmoud, Nasli-Esfahani, Ensieh, Alvandi, Ehsan, Chahardoli, Reza, and Koohdani, Fariba

Published
2018
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32. Effect of Vitamin E Supplementation on Plasma and Urine Levels of Isoprostane F2α in Randomized Controlled Clinical Trials: A Systematic Review and Meta-Analysis

Author

Rad, Esmaeil Youseif, Falahi, Ebrahim, Djalali, Mahmoud, Abbasnezhad, Amir, Brijandi, Mehdi, and Saboori, Somayeh

Abstract

Abstract.Vitamin E can reduce the level of lipid peroxidation and the related markers such as urine and plasma levels of isoprostanes. However, effects of vitamin E supplementation on plasma and urine level of isoprostane F2α as markers of lipid peroxidation were conflicting in various clinical trials. The current meta-analysis was carried out to determine the effects of vitamin E supplementation on plasma and urine levels of isoprostanes F2α in randomized clinical trials. A systematic search of RCTs was carried out in PubMed, Scopus, Science Direct and Cochrane Library databases. OF 889 relevantly founded articles, only four articles with five arms met the criteria for meta-analysis of plasma level of isoprostanes F2α. For the urine level of isoprostane F2α, three studies with 14 arms were included in the meta-analysis. After pooled analyzing, a significant reduction of 6.98 ng / l was seen in plasma level of isoprostane F2α in vitamin E receiving group (95% CI = -11.2, -2.76; P < 0.001) while no significant heterogeneity was seen between the studies included in this meta-analysis (P = 0.81 and I2 = 0.0%). However, the pooled effect of vitamin E supplementation on urine level of isoprostane F2α was not statistically significant (-11.31 pg / mg creatinine (95% CI = -26.4, 3.78; P = 0.88). Results of this meta-analysis have shown that vitamin E supplementation can only reduce plasma level of isoprostane F2α and has no significant effect on reducing urine level of this biomarker.

Published
2024
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34. Effects of Eicosapentaenoic Acid and Vitamin E on the Plasma Levels of Antioxidant Vitamins and Inflammatory Markers, and on Erythrocyte Antioxidant Enzyme Activities, in Male Basketball Players

Author

Djazayery Seyed Abolghassem, Keshavarz Seyed Ali, Hosseini Mostafa, Ghiasvand Reza, and Djalali Mahmoud

Subjects
EPA, vitamin E, inflammation, antioxidant enzymes, lipid peroxidation, Medicine (General), R5-920
Abstract

Strenuous aerobic exercise is associated with oxidative stress and tissue damage. Therefore, we have investigated the effects of exercise and eicosapentaenoic acid supplementation, with or without vitamin E, on the plasma levels of vitamin C, E and A, IL-6, and glutathione peroxidase activity in basketball players. Thirty four male basketball players, enrolled in the study. Subjects received 2g EPA and/or 400 IU vitamin E or placebo depending on their groups. For 6 weeks, eight subjects took a daily EPA sup-plement together with vitamin E (group 1), nine received an EPA supplement together with placebo (group 2), nine were administered placebo along with vitamin E (group 3), and finally, eight subjects received placebo alone (group 4). As compared with group 4 (placebo), there were significant increases in vitamins C, E, and A in groups 1 and 3, but significant decreases in these parameters in group2 (P < 0.01). In addition, there were significant decreases in IL-6 in groups 1 and 3 (P < 0.01), whereas there were significant increases in glutathione peroxidase in groups1 and 3 (P < 0.01).There were significant differences in vitamin C between groups 3 and 4 (P < 0.05), and in vitamin E between groups 1 and 2, and groups 2 and 3 (P < 0.01), and in vitamin A between groups 1 and 2 (P < 0.05), and groups 1 and 4, 2 and 3, and 3 and 4 (P < 0.01), and in IL-6 between groups1 and 2 (P < 0.05), groups 1 and 3 (P < 0.01), 2 and 3 (P < 0.01), 2 and 4 (P < 0.01), and 3 and 4 (P < 0.05).

Published
2009

37. Additional file 2 of The effects of nano-curcumin supplementation on adipokines levels in obese and overweight patients with migraine: a double blind clinical trial study

Author

Sedighiyan, Mohsen, Abdolahi, Mina, Jafari, Elham, Vahabi, Zahra, Sohrabi Athar, Sara, Hadavi, Shima, Narimani Zamanabadi, Mahnaz, Yekaninejad, Mir-Saeed, and Djalali, Mahmoud

Subjects
technology, industry, and agriculture
Abstract

Additional file 2: Figure 2. MCP-1 serum levels in nano-curcumin and control groups. A significant reduction has been observed in MCP-1 levels in nano-curcumin group. This difference also is significant between groups. *P value

Published
2022
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39. The effects of nano-curcumin supplementation on Th2/tregulatory axis in migraine patients: a randomized, double-blind, placebo-controlled trial.

Author

Djalali, Mona, Abdolahi, Mina, Hosseini, Reza, Miraghajani, Maryam, Mohammadi, Hamed, and Djalali, Mahmoud

Subjects
MONONUCLEAR leukocytes, MIGRAINE, DIETARY supplements, GENE expression, CLINICAL trials
Abstract

In the present study we aimed to investigate the effects of nano-curcumin supplementation on gene expression and serum levels of IL-4 and TGF-β in migraine patients. Forty participants with episodic migraine were randomly allocated to receive 80 mg nano-curcumin (n = 20) or placebo (n = 20) in a randomized double-blind clinical trial for two months. At the beginning and the end of the study, the interictal serum levels and gene expression of IL-4 and TGF-β in peripheral blood mononuclear cells (PBMCs) isolated from migraine patients were measured, using ELISA and real-time PCR methods, respectively. Intra-group assays showed a significant rise in the gene expression of both IL-4 and TGF-β (p < 0.05) in nano-curcumin group after two months of treatment, however the serum levels were only significantly changed for IL-4 (p < 0.05). On the contrast, inter-group assays revealed no statistical differences between nano-curcumin and placebo group in terms of IL-4 and TGF-β gene expression, while the serum levels of IL-4 was observed to be increased significantly (p = 0.03) following two month nano-curcumin supplementation. The findings of the present trial suggest that the treatment with nano-curcumin could induce significant levels of IL-4, in favour of anti-inflammatory effects, while has a minimal effects on the both gene expression and serum levels of TGF-β. Further studies are required to determine the exact mechanism of action of curcumin in patients with migraine. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Additional file 1 of The omega-3 and Nano-curcumin effects on vascular cell adhesion molecule (VCAM) in episodic migraine patients: a randomized clinical trial

Author

Abdolahi, Mina, Karimi, Elmira, Sarraf, Payam, Tafakhori, Abbas, Siri, Goli, Salehinia, Farahnaz, Sedighiyan, Mohsen, Asanjarani, Behzad, Badeli, Mostafa, Abdollahi, Hamed, Yoosefi, Niyoosha, yousefi, Abolghasem, rad, Amir Shayegan, and Djalali, Mahmoud

Abstract

Additional file 1: Figure S1. Flow chart for the clinical trial. This Flow chart shows the number of participants in the four study groups, the number of missing in every group as well as participants entered to the analysis.

Published
2021
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43. Risk factors for mortality of adult inpatients with Coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis of retrospective studies

Author

Parohan, Mohammad, Yaghoubi, Sajad, Seraj, Asal, Javanbakht, Mohammad Hassan, Sarraf, Payam, and Djalali, Mahmoud

Abstract

Background: Coronavirus disease 2019 (COVID-19) is an emerging disease that was first reported in Wuhan city, the capital of Hubei province in China, and has subsequently spread worldwide. Risk factors for mortality have not been well summarized. Current meta-analysis of retrospective cohort studies was done to summarize available findings on the association between age, gender, comorbidities and risk of death from COVID-19 infection. Methods: Online databases including Web of Science, PubMed, Scopus and Google scholar were searched to detect relevant publications up to 22 March 2020, using relevant keywords. To pool data, random-effects model was used. Furthermore, sensitivity analysis and publication bias test were also done. Results: In total, six retrospective studies with 22,350 COVID-19 infected patients and 741 cases of death were included in the current meta-analysis. A significant positive association was found between older age (≥65 years old) and COVID-19 mortality (combined effect size=2.39 (over twofold), 95% CIs=1.75-3.28, p

Published
2020
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44. he omega-3 and Nano-curcumin effects on vascular cell adhesion molecule (VCAM) in episodic migraine patients: a randomized clinical trial

Author

Abdolahi, Mina, primary, Karimi, Elmira, additional, Sarraf, Payam, additional, Tafakhori, Abbas, additional, Siri, Goli, additional, Sedighiyan, Mohsen, additional, Asanjarani, Behzad, additional, Djalali, Mahmoud, additional, Badeli, Mostafa, additional, Abdollahi, Hamed, additional, Yoosefi, Niyoosha, additional, Abdullah, Hakima, additional, and Shayegan, Amir, additional

Published
2021
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