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Copyright of Journal of Medical Clinics / Tıp Fakültesi Klinikleri Dergisi is the property of Journal of Medical Clinics / Tip Fakültesi Klinikleri Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Many studies have compared scoring systems in the course of acute pancreatitis (AP), but comparative analyses of scoring systems in patients with diabetes are limited. In our study, we aimed to compare patients using more than one scoring system and also to investigate whether there was a scoring system that could be preferred in predicting the length of hospital stay (LOS) in individuals with diabetes. Methods: Mild and moderate-severe acute pancreatitis patients who were followed up with AP in the internal medicine clinic were evaluated retrospectively. The diagnosis of AP was confirmed in accordance with the revised Atlanta criteria. AP with mild and moderate severity was the inclusion criteria. Patients with severe pancreatitis were excluded. Patients with and without diabetes were analyzed according to demographic characteristics, laboratory and imaging findings in two groups. Ranson, Systemic Inflammatory Response Syndrome (SIRS), Bedside Index of Severity in Acute Pancreatitis (BISAP), Modified Glasgow II Scoring (IMRIE), Harmless Acute Pancreatitis Score (HAPS), Balthazar, and Computed Tomography Severity Index (CTSI) scores were calculated on admission. Results: AP patients with diabetes had higher serum triglyceride, leukocyte, CRP, and procalcitonin levels (p<0.05). Serum amylase levels were slightly higher in non-diabetic patients (p<0.05). The presence of diabetes was positively correlated with Ranson on admission, SIRS, and Imrie scores (p<0.05; r=0.437; r=0.274; r=0.317). Among severity scores, only the CTSI score was significantly higher in patients with >7 days LOS (p<0.004). In addition, while there was no difference in LOS according to the presence of DM (p=0.840), mean HbA1c values were higher in patients with longer LOS (p=0.037). As a result of regression analysis, male gender and higher CTSI scores were related to increased LOS (OR=0.266, p=0.037 vs OR=1.579, p=0.022). Conclusion: Among the scoring systems, IMRIE, SIRS, and Ranson scores were higher in mild-moderate AP patients with diabetes compared to non-diabetic patients. In addition, male gender and higher CTSI scores were associated with increased LOS in this specific patient group. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Psychiatry is the property of Turk Psikiyatri Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Nephrology Nursing (2147-77280 is the property of Journal of Nephrology Nursing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archives of the Turkish Society of Cardiology / Türk Kardiyoloji Derneği Arşivi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Exercise Therapy & Rehabilitation is the property of Yavuz Yakut and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: The aim of this study was to investigate the effect on coronavirus disease-2019 (COVID-19) of glyoxal (GO), which is a precursor of advanced glycation end-products, in diabetic and non-diabetic patients, treated in hospital for COVID-19 who were of similar age and disease severity with similar comorbidities. Methods: The study included 57 patients. Measurement of GO was made with the high-performance liquid chromatography method. Results: The GO values were found to be higher in the diabetic group than in the non-diabetic group (p=0.001, p<0.01). The length of stay in hospital was longer in the diabetic group (p=0.017, p<0.05). The white blood cell, neutrophil, neutrophil/lymphocyte ratio, procalcitonin, and ferritin values were determined to be higher in the diabetic group than in the non-diabetic group (p=0.006; p=0.005, p=0.017, p=0.011, p=0.030). Although the mortality and intensive care unit admission rates were similar in the diabetic and non-diabetic patients of similar age with similar comorbidities and COVID-19 severity, the total length of stay in hospital was determined to be longer in the diabetic patients. Together with other inflammation markers, GO, was determined to be higher in the diabetic group. Conclusion: The results of this study showed that elevated GO could be associated with a prolonged recovery time in COVID-19. [ABSTRACT FROM AUTHOR]

The study aims to determine the effects of sesamin, saponin, sesamin+saponin, tahini, gypsophila extract and tahini+gypsophila extract on aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN) and creatinine levels in experimentally induced type 2 diabetes (T2DM) in mice. 92 Swiss albino male mice were used. After 8 mice were separated as healthy control (HC) group, T2DM was induced by high-fat feeding and streptozotocin (STZ) application. 84 T2DM mice were divided into 7 groups; diabetes control (DC), sesamin (D+SS), saponin (D+SP), sesamin+saponin (D+SS+SP), tahini (D+T), gypsophila extract (D+C) and tahini+gypsophila extract (D+T+C) were applied for 2 weeks. At the end of the research, the animals were euthanized and serum was obtained. Serum AST, ALT, BUN and creatinine levels were measured on an autoanalyzer. AST level was higher than D+SP group (p<0.05), but like D+SP, D+T and DC groups (p>0.05). The AST level of the HC group was lower than DC, D+SP, D+SS+SP and D+T groups (p<0.05). While the ALT levels of DC and D+SP groups were similar to others (p>0.05), they were different from the other groups (p<0.05). While the BUN values of HC and DC groups were similar (p>0.05), BUN values of the two groups were different from the other groups (p<0.05). While the creatinine levels of HC, DC, D+SP and D+T groups were like each other (p>0.05), they were different from the other groups (p<0.05). As a result, it can be stated that the applied substances may have positive effects on T2DM liver and kidney function. [ABSTRACT FROM AUTHOR]

Copyright of Turkiye Klinikleri Journal of Nursing Sciences is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkiye Klinikleri Journal of Nursing Sciences is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: This study aimed to determine the frequency of albuminuria in urine among Type 2 diabetic patients attending primary healthcare and to assess the factors influencing albuminuria. Methods: The research was conducted as a cross-sectional descriptive study between June 1, 2020, and August 31, 2020, at Kanyon Family Health Center in the Vezirköprü district of Samsun province. The study included 211 individuals. After obtaining informed consent from the participants, a face-to-face study form was administered to gather sociodemographic characteristics, smoking habits, comorbidities, and medication information. Albuminuria was detected using test strips, and the color change in the strip was evaluated by the same researcher in daylight each time, and the albumin/creatinine ratio in instantaneous spot urine was approximately calculated. Data analysis was performed with SPSS 24.0 (SPSS 24.0 for Windows, SPSS Inc., Chicago, IL, USA). Results: Of the participants, 52.1% (n=110) were female. The average age was 59.8±13.3 years (min:25-max:80). Hypertension was diagnosed in 47.4%, atherosclerotic heart disease in 27%, hyperlipidemia in 23.7%, obesity in 22.7%, and cerebrovascular disease in 2.4%. When the duration of diabetes diagnosis was evaluated, 27.5% had been diagnosed with diabetes for 0-5 years, 26.6% for 6-10 years, 15.6% for 11-15 years, 14.2% for 16-20 years, and 16.1% for more than 20 years. In addition, 39.3% had been regular smokers for the last 6 months and 37% had never smoked in their lives. 78.7% (n=166) of the patients were normoalbuminuric, 19% (n=40) were microalbuminuria, and 2.4% (n=5) were macroalbuminuria when albumin/creatinine ratio in spot urine was evaluated. The incidence of microalbuminuria and severe albuminuria was significantly higher in older patients, those with longer durations of diabetes, and former smokers (all; p<0.001). A positive correlation was found between age, duration of diabetes, hypertension, obesity, and albuminuria (r: 0.48, r: 0.68, r: 0.47, r: 0.55; p≤0.05, respectively). Microalbuminuria levels were higher in patients who had smoked throughout their lives compared to smokers and never smokers (p≤0.05). Furthermore, patients diagnosed with Type 2 diabetes for 16-20 years and over 20 years had higher microalbuminuria levels than those newly diagnosed (p<0.001). Conclusion: In our study, age, duration of diabetes diagnosis, hypertension, obesity, and smoking history were associated with albuminuria. By integrating practical screening protocols and adopting a holistic approach to patient care, family physicians can play an important role in reducing the burden of diabetic nephropathy in primary health care and improving patient outcomes. [ABSTRACT FROM AUTHOR]

Aim: Diverticular disease is one of the most common gastrointestinal disorders to date, with a notable rising trend in developing countries. However, the proportion of colonic diverticulosis and its associated factors among patients who have undergone colonoscopy remains controversial. This study aimed to determine the local data on the proportion of diverticular disease in the community, its complications, the association of diverticulosis with diabetes mellitus and hypertension, as well as demographic characteristics. Material and Methods: A retrospective review of medical records was performed among patients who had undergone colonoscopy between January and December 2019. Demographic and clinical characteristics, the presence of diabetes mellitus, hypertension, and diverticular disease and its complications were examined, and the association of diverticular disease and its complications with demographic and clinical characteristics were analyzed. Results: Out of 221 patients, 12.7% (n=28) of them had diverticular diseases with a slightly predominant right-sided occurrence (42.9%, n=12). There were significant associations with age (p=0.002), ethnicity (p=0.011), and hypertension (p=0.036), but not with gender and diabetes mellitus (p=0.261, and p=0.334, respectively). There was no significant association between hypertension and recurrence of complicated diverticulitis (p=0.741), septic complications (p=0.678), and diverticular bleeding (p=0.243). Diabetes mellitus was significantly associated with diverticular bleeding complications (p=0.001) but not with septic complications (p=0.418) and recurrence of complicated diverticulitis (p=0.629). Conclusion: This study showed almost a similar percentage of diverticulosis compared to previous local studies. Age, ethnicity, and hypertension were associated with the presence of diverticulosis, and diabetes mellitus was associated with diverticular bleeding.

Introduction: Self-care and self-management skills are at the forefront of disease management skills in individuals with Type 1 and Type 2 diabetes. An individual with diabetes who defines his/her self-care well will have increased his/her disease management skills as well as self-management skills to the desired level. The aim of this study is to evaluate the self-management skills of individuals with Type 1 and Type 2 diabetes receiving insulin therapy according to their sociodemographic characteristics.Method: The research is a prospective analytical study. Within the scope of the study, 913 individuals with Type 1 and Type 2 diabetes who applied to the diabetes polyclinic of a university hospital in Izmir in a month were included. The researchers collected the data through face-to-face interviews into Diabetes Patient Diagnosis Form and Diabetes Self-Management Skill Form.Results: In study 99.8% of the patients received diabetes education at least once and 60.8% of the individuals had never experienced hypoglycemia. When the diabetes self-management skills and self-insulin making skills of individuals with diabetes are examined; A statistically significant difference was found between the diagnostic variable categories in the sub-dimensions of medical nutrition therapy, exercise and treatment management, awareness of chronic complications, and diabetic outpatient care behaviors. It was determined that there was a significant difference between the education styles of individuals with diabetes, the frequency of blood sugar control and the frequency of hypoglycemia, and the sub-dimensions of diabetes self-management skills and the ability to make insulin on their own (p lt;0.001).Conclusion: Diabetes education given to individuals with diabetes contributes to their development of self-management skills. Multiple factors can affect individuals' self-management skills. As the number of educations, type of education, treatment methods, and education level of individuals with diabetes increase, their self-management skills and self-insulin making skills increase. If type 1 and type 2 diabetes patients can be followed closely and their training needs, diversity and application methods can be corrected, disease management will improve. Complications that may develop due to insulin application errors can be prevented.

This article explores the measurement uncertainty of HbA1c and glucose tests, which are used to diagnose diabetes. The study calculates the measurement uncertainties according to ISO/TS 20914 guidelines and analyzes the results retrospectively. The findings indicate that the measurement uncertainty values for these tests are generally within acceptable ranges, but it emphasizes the importance of considering measurement uncertainty in clinical decision-making for diabetes diagnosis and treatment. The article highlights the need for quality and reliability in test results and suggests that false negative and false positive results can still occur despite acceptable measurement uncertainty values. [Extracted from the article]

Copyright of Istanbul Gelisim University Journal of Health Sciences / İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi is the property of Istanbul Gelisim Universitesi Saglik Bilimleri Yuksekokulu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: The present study, in patients with type 2 diabetes; It was aimed to analyze fasting blood glucose, insulin and HbA1c values and trace element (zinc, copper, magnesium and chromium) levels. Material and Method: The study included patients who were 20 patients with type 2 diabetes and 20 healthy controls applied to the Internal Medicine outpatient clinic of Erzurum Regional Training and Research Hospital. The results of the analyzes were calculated with the help of the SPSS (Version 19.0) software package. Results: Levels of HbA1c, glucose, and insulin in the patient group were significantly higher than in the control group. There was no significant difference among levels of plasma zinc (Zn) and copper (Cu) and erythrocyte Cu in the control group and the patient group. Levels of plasma magnesium (Mg) and chromium (Cr) and erythrocyte Zn, Mg and Cr levels in the control group were significantly higher than in the patient group. Levels of plasma and erythrocyte Mg in people with diabetes were significantly lower than in the control group (p <0.005). The levels of plasma and erythrocyte Cr in the group with type 2 diabetes were significantly lower than in the control group. Conclusion: To understand the relationship between diabetes and the trace element, well-specified patient samples should be collected. Studies should be carried out using standard methods. More studies should be done to make sense of the changes in trace element levels in diabetes. The necessity of trace element supplementation as a support for treatment should be investigated. [ABSTRACT FROM AUTHOR]

Diabetes mellitus is a group of chronic metabolic conditions, all of which are characterized by elevated blood glucose levels resulting from the body's inability to produce insulin or resistance to insulin action, or both. Insulin is the main hormone that regulates glucose production and use by body tissues and organs. Diabetes affects all systems in the body, including the liver. Streptozotocin is an antibiotic that performs pancreatic β-cell destruction and is widely used to induce experimental diabetes. In this study; It was aimed to calculate the volume and cell numbers of the morphometric changes caused by streptozotocin-induced diabetes in the rat liver using stereological methods. Twenty adult male rats were used in the study. Four groups were created randomly. Blood glucose values of all groups were measured. Diabetes was induced by administering different doses of streptozotocin (55 mg/kg and 65 mg/kg). After 48 hours, blood glucose values were measured again. Four weeks later, liver tissues of all rats from the control and experimental groups were taken under anesthesia and fixed in 10% formaldehyde. The fixed liver tissues were divided into equal parts by physical fractionation. It was fixed in paraffin after passing through dehydration stages. Histological sections were prepared. It was stained with Hematoxylin-Eosin, examined under a light microscope and photographed. The total volume of the liver was calculated using the Cavalieri Principle and the number of hepatocytes was calculated with the unbiased counting frame of the dissector method. In the diabetes-related groups, the increase in liver volume and cell number was significant compared to the control group (p<0.05). As a result, streptozotocin injection and the resulting diabetes lead to an increase in liver volume and hepatocyte numbers. [ABSTRACT FROM AUTHOR]

Copyright of Eurasian Journal of Veterinary Sciences is the property of Eurasian Journal of Veterinary Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Medical Clinics / Tıp Fakültesi Klinikleri Dergisi is the property of Journal of Medical Clinics / Tip Fakültesi Klinikleri Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Bagcilar Medical Bulletin / Bağcılar Tıp Bülteni is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim: Islets of Langerhans are more sensitive to oxidative damage because of their low antioxidant capacity. In diabetes, methylglyoxal (MG) accumulates in the pancreas. The present study examined the effect of crocin on oxidative stress induced by MG in isolated Langerhans islets from male mice. Material and Methods: Twenty-four male mice weighing 20 to 25 g were prepared. The isolated Langerhans islets were transferred to the culture medium. Oxidative stress was induced through MG administration for 30 min, and then 10, 20, 30, and 40 μM of crocin was used for 2 h. Samples were divided into seven groups with 2.8, 5.6, and 16.7 mM glucose concentrations: control, MG 300 μM, MG+glibenclamide 10 μM, and MG+crocin in four doses of 10, 20, 30, and 40 μM. At the end, the islet’s insulin, antioxidant levels, and lipid peroxidation were assessed by ELISA and calorimetry methods. Results: Increased levels of malondialdehyde (MDA) in MG groups significantly decreased in 2.8 (p=0.008), 5.6 (p=0.004), and 16.7 (p˂0.001) mM glucose concentrations, with administration of 30 and 40 μM crocin. Total antioxidant capacity (TAC) was reduced in MG groups (p˂0.001) and significantly restored in all crocin-treated groups in 2.8, 5.6, and 16.7 mM glucose concentrations. Also, a significant decrease in insulin secretion and content was observed in MG groups of all three glucose concentrations (p˂0.001). Crocin at high doses improved these alterations. Conclusion: MG caused oxidative damage and reduced insulin secretion in isolated islets. Crocin improved the antioxidant defense system, diminished MDA, and increased insulin secretion.

Diabetes is a disease that affects more than 400 million people worldwide and currently lacks a cure. Monitoring blood sugar levels is crucial in minimizing the effects of this disease and protecting against its complications. Invasive and minimally invasive methods are commonly used traditional approaches for detecting and monitoring blood sugar levels. However, these methods bring along psychological and infectious risks. Currently, efforts are being made to develop a noninvasive method for determining blood sugar levels. Microwaves offer the possibility of non-invasive glucose measurement as they do not cause any harmful effects on human tissue. Furthermore, the complex permeability of blood is sensitive to glucose concentration in the microwave band. In literature, most of the studies are done with vector network analyzers (VNA) to detect blood sugar level noninvasively. In this study, an expensive and bulky VNA is replaced by an affordable microwave source and RMS power detector. The influence of the type and diameter of the test tube material used for non-invasive determination of sugar levels is examined with this setup. Additionally, the effect of the distance between the Vivaldi antennas used during measurements and the test tube is investigated. The results indicate that measurements performed using plastic test tubes yield better results compared to glass test tubes. Moreover, reducing the diameter of the test tube leads to improved outcomes. It has been observed that accurate results cannot be obtained if the antennas and the test tube are too close (<0.5 cm) or too far (>4.5cm) from each other. [ABSTRACT FROM AUTHOR]

The aim of this study was to evaluate the changes induced in testicular tissue by administration of dandelion (Taraxacum officinale) extract and its effects on the release of enzymatic antioxidants SOD-2 by immunohistochemical methods in rats with experimental diabetes. Degenerative changes in the seminiferous tubule structure were observed in the testicular sections of the diabetes group. Separations between the basement membrane and the seminiferous epithelium, disruptions in the structure and localization of spermatogenic cells toward the lumen of the seminiferous tubules, thickening of the basement membrane and tunica albuginea, changes in the shape of Sertoli cells, and shrinkage of the nucleus of Leydig cells were observed. While no immunopositivity was observed in spermatogonium and primary spermatocytes in the diabetes group, weak SOD-2 immunoreactivity was observed in other cells of the spermatogenic series and moderate SOD-2 immunoreactivity was observed in the diabetes+dandelion group. In conclusion, it was found that histopathological changes occurred in the testicular tissue and SOD-2 immunoreactivity decreased in diabetes, a chronic metabolic disease. It was concluded that dandelion administration may have beneficial effects on decreased SOD-2 immunoreactivity [ABSTRACT FROM AUTHOR]

Aim: Diverticular disease is one of the most common gastrointestinal disorders to date, with a notable rising trend in developing countries. However, the proportion of colonic diverticulosis and its associated factors among patients who have undergone colonoscopy remains controversial. This study aimed to determine the local data on the proportion of diverticular disease in the community, its complications, the association of diverticulosis with diabetes mellitus and hypertension, as well as demographic characteristics. Material and Methods: A retrospective review of medical records was performed among patients who had undergone colonoscopy between January and December 2019. Demographic and clinical characteristics, the presence of diabetes mellitus, hypertension, and diverticular disease and its complications were examined, and the association of diverticular disease and its complications with demographic and clinical characteristics were analyzed. Results: Out of 221 patients, 12.7% (n=28) of them had diverticular diseases with a slightly predominant right-sided occurrence (42.9%, n=12). There were significant associations with age (p=0.002), ethnicity (p=0.011), and hypertension (p=0.036), but not with gender and diabetes mellitus (p=0.261, and p=0.334, respectively). There was no significant association between hypertension and recurrence of complicated diverticulitis (p=0.741), septic complications (p=0.678), and diverticular bleeding (p=0.243). Diabetes mellitus was significantly associated with diverticular bleeding complications (p=0.001) but not with septic complications (p=0.418) and recurrence of complicated diverticulitis (p=0.629). Conclusion: This study showed almost a similar percentage of diverticulosis compared to previous local studies. Age, ethnicity, and hypertension were associated with the presence of diverticulosis, and diabetes mellitus was associated with diverticular bleeding. [ABSTRACT FROM AUTHOR]

Copyright of Harran University Journal of the Faculty of Veterinary Medicine / Harran Üniversitesi Veteriner Fakültesi Dergisi is the property of Harran University, Faculty of Veterinary Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Statistical Research / İstatistik Araştırma Dergisi is the property of Turkish Statistical Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Faculty of Pharmacy of Ankara University / Ankara Üniversitesi Eczacilik Fakültesi Dergisi is the property of Ankara University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Osmangazi Journal of Medicine / Osmangazi Tip Dergisi is the property of Eskisehir Osmangazi University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Diabetes mellitus is a significant contributor to illness and death on a global scale. Interleukins have been identified as potential factors that can induce apoptosis of beta cells and diminish insulin secretion, resulting in various complications associated with diabetes mellitus. This study investigated the inflammatory cytokines, interleukins, and apoptotic cell death markers in streptozotocin-induced diabetic rats. Lawsonia inermis leaves were sequentially extracted using n-hexane, ethyl acetate, and methanol. Sixty-five male adult Wistar rats were grouped into 13, with 5 rats in each group. Streptozotocin-induced diabetic rats were treated as thus; 25, 50, and 100 mg kg-1 of each of the 3 partitioned extracts, metformin (500 mg kg-1), glibenclamide (5 mg kg-1), and untreated diabetic and nondiabetic rats were treated with distilled water for 28 days. Untreated diabetic rats showed an increased level of cytokines such as interleukin 1, interleukin 6, interleukin 12, and tumor necrosis factor alpha (TNF-a). The methanol fraction significantly decreased interleukin 1, interleukin 6, interleukin 12, interleukin 18, and TNF-a compared to other treatment groups and diabetic control. Methanol fraction of the extract showed a significant reduction in tTNF-a when compared to the 2 standard drugs and the controls. Nuclear factor-kappa beta increased nonsignificantly in both treated and untreated diabetic rats. There was a significant reduction in the expression of caspase-3, caspase-6, and caspase-9 in all the extract-treated groups. It was further noted that there is a slight increase level of B-cell lymphoma 2 in diabetic untreated rats. The study concluded that Lawsonia inermis Linn. has a significant positive modulatory effect on the expression of various cytokines, interleukins, and essential caspases that are implicated in the pathophysiology and pathogenesis of diabetes mellitus. [ABSTRACT FROM AUTHOR]

Copyright of Balikesir Health Sciences Journal / Balıkesir Sağlık Bilimleri Dergisi is the property of Balikesir Health Sciences Journal (BAUN Health Sci J) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Amaç: Bu çalışmada tiroid kanseri türleri ile diabetes mellitus arasındaki ilişkinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: 2016-2018 yılları arasında Hitit Üniversitesi Erol Olçok Eğitim ve Araştırma Hastanesi Patoloji bölümünde tanı alan 406 tiroidektomi olgusu retrospektif olarak hastane bilgisayar kayıt sisteminden ve Patoloji kliniği arşivinden tarandı. Bu vakalar içerisinden tiroid kanseri tanısı alanlar belirlendi. Tiroid kanserli olgulardan Diyabetes Mellitus tanılı olanlar hastane bilgi sisteminden tespit edildi. Olgular tanılarına, cinsiyet, yaş, tümör tipi, tümör lokalizasyonu, tümör çapı, lenf nodu metastazı ve uzak organ metastazı açısından sınıflandırıldı. İmmünohistokimyasal HBME1, Galaktin 3 ve Sitokeratin-19 ekspresyonu incelendi. Bulgular: Tiroid karsinomu tanısı alan 109 olgu vardı. Bu olguların yaş ortalaması 51,1’di. Kadın/erkek oranı 2,9’du. Kanser olguları 4. dekatta en yüksek oranda görülmekteydi. Tiroid papiller karsinom 55 (%50,5), mikrokarsinom 48 (%44,0), folliküler karsinom 3 (%2,8) ve medüller karsinom tanısı alan 3 (%2,8) olgu vardı. Olguların 12’inde (%11,0) vasküler invazyon ve kapsül invazyonu vardı. Tiroid papiller karsinom tanısı alan 2 (%1,8) olguda lenf nodu metastazı vardı. Tiroid kanserli 109 hastanın 14’ünde (%12,8) diyabetes mellitus vardı. Çalışma grubumuzdaki hastaların diyabet oranı ile genel popülasyon diyabet oranı karşılaştırıldığında istatistiksel olarak anlamlı farklılık saptanmamıştır (p=0,519). Sonuç: Çalışmamızda diyabetin tiroid kanseri için bir risk faktörü olmadığı görülmüştür. Diyabetin düşük orandaki birlikteliği nedeniyle, diyabetli hastalarda tiroid bezi kontrolünün yapılmasının gerekliliği ortaya çıkmıştır. Diyabetin tiroid kanseri için bir risk faktörü olduğunu belirtmek için daha çok veriye ihtiyaç vardır.

Objective: This study aimed to assess osteoporosis knowledge among individuals diagnosed with type 2 diabetes mellitus (T2DM) receiving care in Ulaanbaatar hospitals. Materials and Methods: Conducted as a cross-sectional survey, the study included 644 participants, both male and female, aged between 20 and 65, all diagnosed with T2DM. Participants completed an online questionnaire evaluating their understanding of international osteoporosis within a 20-30-minute timeframe, amid the coronavirus disease-2019 pandemic in 2021. Knowledge levels were categorized using an Osteoporosis Knowledge Assessment Tool (OKAT), defining a good score as ≥20, a moderate score as 14-19, and a poor score as ≤1-13. Multivariate logistic regression analyses were employed to discern predictors of OKAT scores. Results: Among the participants, 90.2% were married, 3.6% were unmarried, and 6.2% were divorced. Osteoporosis knowledge varied, with 1.08% demonstrating good knowledge, 25.62% having intermediate knowledge, and 73.3% possessing poor knowledge. Participants were stratified by T2DM duration, revealing that 47.5% had been diagnosed for 0-5 years, 26.86% for 6-10 years, and 25.62% for more than 11 years. Smoking was reported by 25% of participants, with 78.5% of males and 69.4% of females exhibiting poor osteoporosis knowledge. Among smokers, 0.6% had good knowledge, 24.2% had moderate knowledge, and 75.2% had poor knowledge. After adjusting for gender, odds ratios (OR) indicated that lower education was significantly linked to osteoporosis knowledge in T2DM (OR, 1.50; p=0.002). Additionally, OR for ophthalmic diseases and rheumatoid arthritis demonstrated a significant impact on osteoporosis knowledge in T2DM (OR, 1.01; p=0.001; OR, 1.20; p=0.001). Conclusion: Patients aged 20-65 diagnosed with T2DM displayed insufficient knowledge about osteoporosis. The findings underscore the necessity for enhancing awareness and understanding of osteoporosis, particularly among individuals with diabetes. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to investigate the relationship between thyroid cancer types and Diabetes Mellitus (DM). Material and Methods: Between 2016-2018, 406 thyroidectomy cases diagnosed in the Pathology department of Hitit University Erol Olçok Training and Research Hospital were retrospectively reviewed from the hospital computer registration system and the archive of the Pathology clinic. Among these cases, patients diagnosed with thyroid cancer were identified. Among the thyroid cancer cases, those diagnosed with DM were identified using hospital records. Cases were classified based on diagnosis, gender, age, tumor type, tumor localization, tumor diameter, lymph node metastasis, and distant organ metastasis. HBME1, Galactin 3, and Cytokeratin-19 expression were analyzed immunohistochemically. Results: There were 109 patients diagnosed with thyroid carcinoma. The mean age of these patients was 51.1 years, and the male/female ratio was 2.9. Cancer cases were most common in the fourth decade. There were 55 (50.5%) cases of thyroid papillary carcinoma, 48 (44.0%) cases of microcarcinoma, 3 (2.8%) cases of follicular carcinoma and 3 (2.8%) cases of medullary carcinoma. Vascular invasion and capsular invasion were observed in 12 cases (11.0%). Lymph node metastasis was present in 2 (1.8%) patients diagnosed with thyroid papillary carcinoma. DM was present in 14 (12.8%) of 109 patients with thyroid cancer. When the DM rate of the patients in our study group was compared with the DM rate in the general population, no statistically significant difference was found (p=0.519). Conclusion: In our study, DM was not found to be a risk factor for thyroid cancer. Due to the low association rate of DM, it is necessary to check the thyroid gland in patients with diabetes mellitus. More data and further studies are needed to indicate that diabetes is a risk factor for thyroid cancer. [ABSTRACT FROM AUTHOR]

Objective: Worldwide, phytotherapy methods acquire great importance, and studies in this field are increasing their importance each day. This study, it was aimed to examine total antioxidant, oxidant status, oxidative DNA damage, glucose and hemoglobin A1c levels and the effects of barley grass juice on these parameters in rats with diabetes mellitus. Material and Method: Four groups were formed for the study and 6 male rats weighing 250-350 g were used in each group. Control Group; physiological saline was injected via intraperitoneal., Diabetic Group; created using streptozotocin, Barley Grass Group; Barley grass juice (3 ml/rat/day) was given orally for 4 weeks, Diabetic and Barley Grass Group; was injected streptozotocin and barley grass juice was given by oral for 4 weeks. Results: It was determined that barley grass juice decreased blood sugar, glucose, hemoglobin A1c, total oxidative status and oxidative stress index values, increased total anti-oxidative status value, and body weights in streptozotocin-induced diabetes. In addition, it was determined that the addition of barley grass juice provided a significant protective effect and improvement in these parameters. Conclusion: Based on these findings, we can say that barley grass juice has an antidiabetic-antioxidant effect and weight gain in diabetes mellitus. [ABSTRACT FROM AUTHOR]

Diabetes is a metabolic disease that is common worldwide. The number of people suffering from diabetes is expected to increase every year around the world. This means a negative impact on both the comfort of life of individuals and the health system. In this respect, it is important to diagnose the disease at an early stage. The high dimensionality of the data used for diagnostic purposes has a negative effect on the cost and time of the calculation. To avoid this, it is important to select the most valuable features for diagnosis. In this study, feature selection was made using Salp Swarm Algorithm, Artificial Bee Colony Algorithm, Whale Optimization Algorithm and Ant Colony Algorithm using the samples in the UCI (UCI Machine Learning Repository) data store. In order to evaluate the selected features, accuracy, sensitivity and specificity parameters were calculated using k-Nearest Neighborhood (KNN), Naive Bayes (NB), Support Vector Machine (SVM) and Artificial Neural Networks (ANN) methods. In the calculations for the probability of having diabetes, an accuracy rate of 99.04% was obtained with the k-Nearest Neighborhood method. [ABSTRACT FROM AUTHOR]

Copyright of Meandros Medical & Dental Journal is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Current Retina Journal / Güncel Retina Dergisi is the property of Anadolu Kitabevi Basim Yayim Medikal Turizm Kirtasiye Tic. Ltd. Sti. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Current Retina Journal / Güncel Retina Dergisi is the property of Anadolu Kitabevi Basim Yayim Medikal Turizm Kirtasiye Tic. Ltd. Sti. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Current Retina Journal / Güncel Retina Dergisi is the property of Anadolu Kitabevi Basim Yayim Medikal Turizm Kirtasiye Tic. Ltd. Sti. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Health Academics / Sağlık Akademisyenleri Dergisi is the property of Journal of Health Academics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Leukocytoclastic vasculitis is a cutaneous small-vessel vasculitis characterized by inflammation and necrosis of the vessel wall. It is usually limited to the skin but may rarely affect organs such as the kidney. A 58-year-old female patient presented with palpable petechiae-purpura on the skin after initiating metformin for type 2 diabetes mellitus. Renal biopsy was performed due to hematuria and proteinuria. The renal biopsy showed proliferative glomerulonephritis. After other causes of vasculitis were excluded, a diagnosis of metformin-induced vasculitis was considered. The patient was started on methylprednisolone and azathioprine treatment. Skin findings disappeared completely after two months, and glomerulonephritis resolved at 9 months. [ABSTRACT FROM AUTHOR]

Aim: Islets of Langerhans are more sensitive to oxidative damage because of their low antioxidant capacity. In diabetes, methylglyoxal (MG) accumulates in the pancreas. The present study examined the effect of crocin on oxidative stress induced by MG in isolated Langerhans islets from male mice. Material and Methods: Twenty-four male mice weighing 20 to 25 g were prepared. The isolated Langerhans islets were transferred to the culture medium. Oxidative stress was induced through MG administration for 30 min, and then 10, 20, 30, and 40 μM of crocin was used for 2 h. Samples were divided into seven groups with 2.8, 5.6, and 16.7 mM glucose concentrations: control, MG 300 μM, MG+glibenclamide 10 μM, and MG+crocin in four doses of 10, 20, 30, and 40 μM. At the end, the islet's insulin, antioxidant levels, and lipid peroxidation were assessed by ELISA and calorimetry methods. Results: Increased levels of malondialdehyde (MDA) in MG groups significantly decreased in 2.8 (p=0.008), 5.6 (p=0.004), and 16.7 (p<0.001) mM glucose concentrations, with administration of 30 and 40 μM crocin. Total antioxidant capacity (TAC) was reduced in MG groups (p<0.001) and significantly restored in all crocin-treated groups in 2.8, 5.6, and 16.7 mM glucose concentrations. Also, a significant decrease in insulin secretion and content was observed in MG groups of all three glucose concentrations (p<0.001). Crocin at high doses improved these alterations. Conclusion: MG caused oxidative damage and reduced insulin secretion in isolated islets. Crocin improved the antioxidant defense system, diminished MDA, and increased insulin secretion. [ABSTRACT FROM AUTHOR]

Copyright of Bagcilar Medical Bulletin / Bağcılar Tıp Bülteni is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Tip 1 diyabet pankreasın insülini çok az salgıladığı ya da hiç salgılamadığı durumlarda görülen kronik bir hastalıktır. Çocukluk çağında ve adölesan dönemde görülmesi kronik hastalığın yönetimini daha da zorlaştırmaktadır. Diyabet yönetiminin eğitim, beslenme, egzersiz, medikal süreç gibi bileşenlerle multidisipliner bir ekip tarafından yönetilmesi gerekir. Watson’un insan bakım modeli hümanistik ve holistik bir yaklaşımı hemşirelik bakımında esas alarak kronik hastalık yönetiminde iyilik halinin sağlanabileceğini savunmuştur. Watson’a göre birey ile hemşire arasındaki bağın gelişmesinde, bireyin yargılanmadan dinlenmesi, hoşgörülü olunması, sevgi ve saygıyı içeren iletişim ile gerçekleşmektedir. Birey ile hemşire arasındaki bağ bakımın etkinliğini göstermektedir. Adölesan dönemdeki birey gelişimine bağlı olarak bağımsızlık kazanmak ister ve kronik hastalık yönetimi bu dönemde oldukça zordur. İnsan bakım modeli çerçevesinde bakım verilen adölesanı yargılamadan dinlemek, adölesanın güvenini kazanmak ve kişiliğini kabul etmek bu dönemde birey hemşire arasındaki bağı kuvvetlendirecek ve bakımın kalitesini arttıracaktır.

Amaç: Hastanemiz iç hastalıkları polikliniklerine başvuran 65 yaş ve üzerindeki tip 2 diyabetes mellitusun eşlik ettiği hastalarda anemi sıklığını saptamayı ve aneminin morfolojik olarak dağılımını değerlendirmeyi amaçladık. Yöntem ve gereçler: Dereli İlçe Devlet Hastanesi iç hastalıkları polikliniğine 01.01.2021– 01.01.2022 tarihleri arasında başvuran 65 yaş ve üzerindeki tip 2 dm’nin eşlik ettiği hastalar, retrospektif olarak incelenerek çalışmaya alındı. Hastaların hemogram ve biyokimya tetkikleri değerlendirildi. Hastaların anemi sıklığı ile yaş, cinsiyet, kronik renal yetmezlik ilişkileri değerlendirildi. Veriler SPSS programına kaydedilip, istatistiksel analizler yapıldı. Bulgular: Çalışmamızda anemi sıklığı %24,4 olarak saptandı. Anemisi olan hastalar MCV değerlerine göre %26’ sı (26) mikrositer, %72’ si (72) normositer, %2’ si (2) makrositer anemi olarak sınıflandırıldı. Çalışmamızda kadınlarda, erkeklere göre anemi sıklığı açısından istatistiksel anlamlı farklılık tespit edildi (p=0,016). Artan yaş grupları ile anemi sıklığı arasında istatistiksel anlamlı farklılık gözlenmedi (p=0,088). Geriatrik diyabetik hastalarda kronik renal yetmezlik ile anemi arasında istatistiksel anlamlı farklılık tespit edildi (p=0,008). Sonuç: Çalışmamızdaki hastalarda anemi sıklığı literatürle uyumlu olarak %24,4 olarak saptandı. Geriatrik diyabetik hasta popülasyonu gittikçe artmaktadır. Ülkemizde geriatrik gruptaki diyabetik hastalarda anemi ile ilgili çalışmalar kısıtlı olup, çok merkezli prospektif çalışmalara gereksinim duyulmaktadır.

Mondor's disease (MD) is a rare disorder characterized by superficial thrombophlebitis or subcutaneous venous thrombosis. It is commonly seen on the anterior chest wall. Penile Mondor's disease (PMD) is seen less frequently than thoracic MD and presents as an indurated cord-like lesion along the vein tract. A 47-year-old patient presented to our outpatient clinic with a complaint of a painless, indurated, and sudden-onset lesion on the penis shaft that lasted for 15 days. He was using systemic steroids and antidiabetics for pemphigus and diabetes. He had a cord-like lesion along the penis shaft, becoming more prominent by stretching the skin. He was clinically diagnosed with PMD, regressing spontaneously after 1-week of sexual rest. He denied other triggering factors except for strenuous sexual activity. In this case, we think that diabetic angiopathy and the prothrombotic effect of steroids may have contributed to the development of PMD besides vigorous sexual activity. We found it valuable to share because of its rarity. [ABSTRACT FROM AUTHOR]

Copyright of Karya Journal of Health Science is the property of Karya Journal of Health Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkish Journal of Health & Sport is the property of Turkish Journal of Health & Sport and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Diabetes is a metabolic disease characterized by abnormally high blood sugar levels and has been known for centuries to be closely related to nutrition. The first scientific approaches to medical nutrition therapy regarding diabetes intensified at the beginning of the 20th century. However, the literature on dietary recommendations and clinical practices for this disease is quite limited. This study investigates medical nutrition therapy regarding diabetes from a century ago in light of information obtained from a booklet titled What Should Diabetics Eat? (Istanbul, 1929), which was published in Ottoman Turkish while the Alphabet Reform being implemented in the early years of the Turkish Republic. The booklet was written by Dr. Mehmet Kâmil, an internist at Şişli Etfal Hospital, and by Dr. Muzaffer, the physician at Galatasaray High School. The work was prepared as a diabetes booklet and includes nutritional recommendations that diabetic individuals should follow within the framework of the medical experience of that period. This study compares the recommendations given in the booklet both with the scientific literature of the period and with current practices and evaluates the changes that have occurred in clinical nutrition therapy regarding diabetes up until the present day. The present article also includes information about the authors of the booklet, as well as its full text in Latin characters. [ABSTRACT FROM AUTHOR]