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208 results on '"Dixit, Deobrat"'

1. Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma

Author

Chapman, Owen S, Luebeck, Jens, Sridhar, Sunita, Wong, Ivy Tsz-Lo, Dixit, Deobrat, Wang, Shanqing, Prasad, Gino, Rajkumar, Utkrisht, Pagadala, Meghana S, Larson, Jon D, He, Britney Jiayu, Hung, King L, Lange, Joshua T, Dehkordi, Siavash R, Chandran, Sahaana, Adam, Miriam, Morgan, Ling, Wani, Sameena, Tiwari, Ashutosh, Guccione, Caitlin, Lin, Yingxi, Dutta, Aditi, Lo, Yan Yuen, Juarez, Edwin, Robinson, James T, Korshunov, Andrey, Michaels, John-Edward A, Cho, Yoon-Jae, Malicki, Denise M, Coufal, Nicole G, Levy, Michael L, Hobbs, Charlotte, Scheuermann, Richard H, Crawford, John R, Pomeroy, Scott L, Rich, Jeremy N, Zhang, Xinlian, Chang, Howard Y, Dixon, Jesse R, Bagchi, Anindya, Deshpande, Aniruddha J, Carter, Hannah, Fraenkel, Ernest, Mischel, Paul S, Wechsler-Reya, Robert J, Bafna, Vineet, Mesirov, Jill P, and Chavez, Lukas

Subjects
Agricultural, Veterinary and Food Sciences, Biological Sciences, Bioinformatics and Computational Biology, Genetics, Agricultural Biotechnology, Rare Diseases, Precision Medicine, Cancer, Pediatric Cancer, Pediatric, Cancer Genomics, Human Genome, Brain Cancer, Brain Disorders, Humans, DNA, Circular, Medulloblastoma, Retrospective Studies, Neoplasms, Oncogenes, Cerebellar Neoplasms, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Circular extrachromosomal DNA (ecDNA) in patient tumors is an important driver of oncogenic gene expression, evolution of drug resistance and poor patient outcomes. Applying computational methods for the detection and reconstruction of ecDNA across a retrospective cohort of 481 medulloblastoma tumors from 465 patients, we identify circular ecDNA in 82 patients (18%). Patients with ecDNA-positive medulloblastoma were more than twice as likely to relapse and three times as likely to die within 5 years of diagnosis. A subset of tumors harbored multiple ecDNA lineages, each containing distinct amplified oncogenes. Multimodal sequencing, imaging and CRISPR inhibition experiments in medulloblastoma models reveal intratumoral heterogeneity of ecDNA copy number per cell and frequent putative 'enhancer rewiring' events on ecDNA. This study reveals the frequency and diversity of ecDNA in medulloblastoma, stratified into molecular subgroups, and suggests copy number heterogeneity and enhancer rewiring as oncogenic features of ecDNA.

Published
2023

2. IFI35 regulates non-canonical NF-κB signaling to maintain glioblastoma stem cells and recruit tumor-associated macrophages

Author

Li, Daqi, Wang, Xiefeng, Chen, Kexin, Shan, Danyang, Cui, Gaoyuan, Yuan, Wei, Lin, Qiankun, Gimple, Ryan C., Dixit, Deobrat, Lu, Chenfei, Gu, Danling, You, Hao, Gao, Jiancheng, Li, Yangqing, Kang, Tao, Yang, Junlei, Yu, Hang, Song, Kefan, Shi, Zhumei, Fan, Xiao, Wu, Qiulian, Gao, Wei, Zhu, Zhe, Man, Jianghong, Wang, Qianghu, Lin, Fan, Tao, Weiwei, Mack, Stephen C., Chen, Yun, Zhang, Junxia, Li, Chaojun, Zhang, Nu, You, Yongping, Qian, Xu, Yang, Kailin, Rich, Jeremy N., Zhang, Qian, and Wang, Xiuxing

Published
2024
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5. The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies

Author

Prager, Briana C, Vasudevan, Harish N, Dixit, Deobrat, Bernatchez, Jean A, Wu, Qiulian, Wallace, Lisa C, Bhargava, Shruti, Lee, Derrick, King, Bradley H, Morton, Andrew R, Gimple, Ryan C, Pekmezci, Melike, Zhu, Zhe, Siqueira-Neto, Jair L, Wang, Xiuxing, Xie, Qi, Chen, Clark, Barnett, Gene H, Vogelbaum, Michael A, Mack, Stephen C, Chavez, Lukas, Perry, Arie, Raleigh, David R, and Rich, Jeremy N

Subjects
Brain Cancer, Orphan Drug, Human Genome, Cancer, Genetics, Rare Diseases, Neurosciences, Brain Disorders, Epigenomics, Humans, Meningioma, Prognosis, Oncology and Carcinogenesis
Abstract

Meningiomas are the most common primary intracranial tumor with current classification offering limited therapeutic guidance. Here, we interrogated meningioma enhancer landscapes from 33 tumors to stratify patients based upon prognosis and identify novel meningioma-specific dependencies. Enhancers robustly stratified meningiomas into three biologically distinct groups (adipogenesis/cholesterol, mesodermal, and neural crest) distinguished by distinct hormonal lineage transcriptional regulators. Meningioma landscapes clustered with intrinsic brain tumors and hormonally responsive systemic cancers with meningioma subgroups, reflecting progesterone or androgen hormonal signaling. Enhancer classification identified a subset of tumors with poor prognosis, irrespective of histologic grading. Superenhancer signatures predicted drug dependencies with superior in vitro efficacy to treatment based upon the NF2 genomic profile. Inhibition of DUSP1, a novel and druggable meningioma target, impaired tumor growth in vivo. Collectively, epigenetic landscapes empower meningioma classification and identification of novel therapies. SIGNIFICANCE: Enhancer landscapes inform prognostic classification of aggressive meningiomas, identifying tumors at high risk of recurrence, and reveal previously unknown therapeutic targets. Druggable dependencies discovered through epigenetic profiling potentially guide treatment of intractable meningiomas.This article is highlighted in the In This Issue feature, p. 1611.

Published
2020

6. Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions

Author

Tang, Min, Xie, Qi, Gimple, Ryan C, Zhong, Zheng, Tam, Trevor, Tian, Jing, Kidwell, Reilly L, Wu, Qiulian, Prager, Briana C, Qiu, Zhixin, Yu, Aaron, Zhu, Zhe, Mesci, Pinar, Jing, Hui, Schimelman, Jacob, Wang, Pengrui, Lee, Derrick, Lorenzini, Michael H, Dixit, Deobrat, Zhao, Linjie, Bhargava, Shruti, Miller, Tyler E, Wan, Xueyi, Tang, Jing, Sun, Bingjie, Cravatt, Benjamin F, Muotri, Alysson R, Chen, Shaochen, and Rich, Jeremy N

Subjects
Stem Cell Research, Rare Diseases, Biotechnology, Stem Cell Research - Nonembryonic - Human, Neurosciences, Brain Disorders, Brain Cancer, Cancer, Animals, Bioprinting, Cell Line, Tumor, Cell Proliferation, Glioblastoma, Humans, Mice, Neural Stem Cells, Tissue Scaffolds, Tumor Microenvironment, Biochemistry and Cell Biology, Clinical Sciences, Developmental Biology
Abstract

Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain tumor microenvironment in a reproducible and scalable system, we developed a rapid three-dimensional (3D) bioprinting method to construct clinically relevant biomimetic tissue models. In recurrent glioblastoma, macrophages/microglia prominently contribute to the tumor mass. To parse the function of macrophages in 3D, we compared the growth of glioblastoma stem cells (GSCs) alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel, with or without macrophage. Bioprinted constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival, maintenance of stemness, invasion, and drug resistance. Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs, relative to sphere culture. Multicellular bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity, cellular crosstalk, invasion, context-specific functional dependencies, as well as immunologic interactions in a species-matched neural environment.

Published
2020

8. A peptide encoded by upstream open reading frame of MYC binds to tropomyosin receptor kinase B and promotes glioblastoma growth in mice.

Author

Li, Fanying, Yang, Kailin, Gao, Xinya, Zhang, Maolei, Gu, Danling, Wu, Xujia, Lu, Chenfei, Wu, Qiulian, Dixit, Deobrat, Gimple, Ryan C., You, Yongping, Mack, Stephen C., Shi, Yu, Kang, Tiebang, Agnihotri, Sameer A., Taylor, Michael D., Rich, Jeremy N., Zhang, Nu, and Wang, Xiuxing

Subjects
TUMOR growth, PEPTIDES, GLIOBLASTOMA multiforme, STEM cells, TROPOMYOSINS, XENOGRAFTS
Abstract

MYC promotes tumor growth through multiple mechanisms. Here, we show that, in human glioblastomas, the variant MYC transcript encodes a 114–amino acid peptide, MYC pre-mRNA encoded protein (MPEP), from the upstream open reading frame (uORF) MPEP. Secreted MPEP promotes patient-derived xenograft tumor growth in vivo, independent of MYC through direct binding, and activation of tropomyosin receptor kinase B (TRKB), which induces downstream AKT-mTOR signaling. Targeting MPEP through genetic ablation reduced growth of patient-derived 4121 and 3691 glioblastoma stem cells. Administration of an MPEP-neutralizing antibody in combination with a small-molecule TRKB inhibitor reduced glioblastoma growth in patient-derived xenograft tumor–bearing mice. The overexpression of MPEP in surgical glioblastoma specimens predicted a poor prognosis, supporting its clinical relevance. In summary, our results demonstrate that tumor-specific translation of a MYC-associated uORF promotes glioblastoma growth, suggesting a new therapeutic strategy for glioblastoma. Editor's summary: Upstream open reading frames (uORFs) are RNA sequences encoding short peptides that mainly function as translational represssors. Here, Li et al. show that the uORF of the oncogene MYC is translated into a peptide (MPEP) that is secreted from glioblastoma stem cells (GSCs). MPEP expression promoted proliferation of GSCs in vitro and accelerated tumorigenesis in a mouse model. MPEP acted through canonical activation of tropomyosin receptor kinase B, which was corroborated by the increase in survival rates of glioblastoma mice undergoing combination treatment with an MPEP antibody and the TRK inhibitor entrecitinib. —Daniela Neuhofer [ABSTRACT FROM AUTHOR]

Published
2024
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9. Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism

Author

Zhao, Linjie, primary, Qiu, Zhixin, additional, Yang, Zhengnan, additional, Xu, Lian, additional, Pearce, Thomas M., additional, Wu, Qiulian, additional, Yang, Kailin, additional, Li, FuLong, additional, Saulnier, Olivier, additional, Fei, Fan, additional, Yu, Huaxu, additional, Gimple, Ryan C., additional, Varadharajan, Venkateshwari, additional, Liu, Juxiu, additional, Hendrikse, Liam D., additional, Fong, Vernon, additional, Wang, Wei, additional, Zhang, Jiao, additional, Lv, Deguan, additional, Lee, Derrick, additional, Lehrich, Brandon M., additional, Jin, Chunyu, additional, Ouyang, Liang, additional, Dixit, Deobrat, additional, Wu, Haoxing, additional, Wang, Xiang, additional, Sloan, Andrew E., additional, Wang, Xiuxing, additional, Huan, Tao, additional, Mark Brown, J., additional, Goldman, Steven A., additional, Taylor, Michael D., additional, Zhou, Shengtao, additional, and Rich, Jeremy N., additional

Published
2024
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10. Figure S1-S6, Table S1 from β2-Microglobulin Maintains Glioblastoma Stem Cells and Induces M2-like Polarization of Tumor-Associated Macrophages

Author

Li, Daqi, primary, Zhang, Qian, primary, Li, Lu, primary, Chen, Kexin, primary, Yang, Junlei, primary, Dixit, Deobrat, primary, Gimple, Ryan C., primary, Ci, Shusheng, primary, Lu, Chenfei, primary, Hu, Lang, primary, Gao, Jiancheng, primary, Shan, Danyang, primary, Li, Yangqing, primary, Zhang, Junxia, primary, Shi, Zhumei, primary, Gu, Danling, primary, Yuan, Wei, primary, Wu, Qiulian, primary, Yang, Kailin, primary, Zhao, Linjie, primary, Qiu, Zhixin, primary, Lv, Deguan, primary, Gao, Wei, primary, Yang, Hui, primary, Lin, Fan, primary, Wang, Qianghu, primary, Man, Jianghong, primary, Li, Chaojun, primary, Tao, Weiwei, primary, Agnihotri, Sameer, primary, Qian, Xu, primary, Shi, Yu, primary, You, Yongping, primary, Zhang, Nu, primary, Rich, Jeremy N., primary, and Wang, Xiuxing, primary

Published
2023
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11. Data from β2-Microglobulin Maintains Glioblastoma Stem Cells and Induces M2-like Polarization of Tumor-Associated Macrophages

Author

Li, Daqi, primary, Zhang, Qian, primary, Li, Lu, primary, Chen, Kexin, primary, Yang, Junlei, primary, Dixit, Deobrat, primary, Gimple, Ryan C., primary, Ci, Shusheng, primary, Lu, Chenfei, primary, Hu, Lang, primary, Gao, Jiancheng, primary, Shan, Danyang, primary, Li, Yangqing, primary, Zhang, Junxia, primary, Shi, Zhumei, primary, Gu, Danling, primary, Yuan, Wei, primary, Wu, Qiulian, primary, Yang, Kailin, primary, Zhao, Linjie, primary, Qiu, Zhixin, primary, Lv, Deguan, primary, Gao, Wei, primary, Yang, Hui, primary, Lin, Fan, primary, Wang, Qianghu, primary, Man, Jianghong, primary, Li, Chaojun, primary, Tao, Weiwei, primary, Agnihotri, Sameer, primary, Qian, Xu, primary, Shi, Yu, primary, You, Yongping, primary, Zhang, Nu, primary, Rich, Jeremy N., primary, and Wang, Xiuxing, primary

Published
2023
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12. Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression

Author

Wang, Xiuxing, Prager, Briana C., Wu, Qiulian, Kim, Leo J.Y., Gimple, Ryan C., Shi, Yu, Yang, Kailin, Morton, Andrew R., Zhou, Wenchao, Zhu, Zhe, Obara, Elisabeth Anne Adanma, Miller, Tyler E., Song, Anne, Lai, Sisi, Hubert, Christopher G., Jin, Xun, Huang, Zhi, Fang, Xiaoguang, Dixit, Deobrat, Tao, Weiwei, Zhai, Kui, Chen, Cong, Dong, Zhen, Zhang, Guoxin, Dombrowski, Stephen M., Hamerlik, Petra, Mack, Stephen C., Bao, Shideng, and Rich, Jeremy N.

Published
2018
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13. Supplementary Data 1 from Dual Role of CXCL8 in Maintaining the Mesenchymal State of Glioblastoma Stem Cells and M2-Like Tumor-Associated Macrophages

Author

Yuan, Wei, primary, Zhang, Qian, primary, Gu, Danling, primary, Lu, Chenfei, primary, Dixit, Deobrat, primary, Gimple, Ryan C., primary, Gao, Yisu, primary, Gao, Jiancheng, primary, Li, Daqi, primary, Shan, Danyang, primary, Hu, Lang, primary, Li, Lu, primary, Li, Yangqing, primary, Ci, Shusheng, primary, You, Hao, primary, Yan, Linping, primary, Chen, Kexin, primary, Zhao, Ningwei, primary, Xu, Chuanhai, primary, Lan, Jianyun, primary, Liu, Dong, primary, Zhang, Junxia, primary, Shi, Zhumei, primary, Wu, Qiulian, primary, Yang, Kailin, primary, Zhao, Linjie, primary, Qiu, Zhixin, primary, Lv, Deguang, primary, Gao, Wei, primary, Yang, Hui, primary, Lin, Fan, primary, Wang, Qianghu, primary, Man, Jianghong, primary, Li, Chaojun, primary, Tao, Weiwei, primary, Agnihotri, Sameer, primary, Qian, Xu, primary, Mack, Stephen C., primary, Zhang, Nu, primary, You, Yongping, primary, Rich, Jeremy N., primary, Sun, Guan, primary, and Wang, Xiuxing, primary

Published
2023
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14. Data from Dual Role of CXCL8 in Maintaining the Mesenchymal State of Glioblastoma Stem Cells and M2-Like Tumor-Associated Macrophages

Author

Yuan, Wei, primary, Zhang, Qian, primary, Gu, Danling, primary, Lu, Chenfei, primary, Dixit, Deobrat, primary, Gimple, Ryan C., primary, Gao, Yisu, primary, Gao, Jiancheng, primary, Li, Daqi, primary, Shan, Danyang, primary, Hu, Lang, primary, Li, Lu, primary, Li, Yangqing, primary, Ci, Shusheng, primary, You, Hao, primary, Yan, Linping, primary, Chen, Kexin, primary, Zhao, Ningwei, primary, Xu, Chuanhai, primary, Lan, Jianyun, primary, Liu, Dong, primary, Zhang, Junxia, primary, Shi, Zhumei, primary, Wu, Qiulian, primary, Yang, Kailin, primary, Zhao, Linjie, primary, Qiu, Zhixin, primary, Lv, Deguang, primary, Gao, Wei, primary, Yang, Hui, primary, Lin, Fan, primary, Wang, Qianghu, primary, Man, Jianghong, primary, Li, Chaojun, primary, Tao, Weiwei, primary, Agnihotri, Sameer, primary, Qian, Xu, primary, Mack, Stephen C., primary, Zhang, Nu, primary, You, Yongping, primary, Rich, Jeremy N., primary, Sun, Guan, primary, and Wang, Xiuxing, primary

Published
2023
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15. Table S3 from Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells

Author

Qiu, Zhixin, primary, Zhao, Linjie, primary, Shen, Jia Z., primary, Liang, Zhengyu, primary, Wu, Qiulian, primary, Yang, Kailin, primary, Min, Lihua, primary, Gimple, Ryan C., primary, Yang, Qiyuan, primary, Bhargava, Shruti, primary, Jin, Chunyu, primary, Kim, Cheryl, primary, Hinz, Denise, primary, Dixit, Deobrat, primary, Bernatchez, Jean A., primary, Prager, Briana C., primary, Zhang, Guoxin, primary, Dong, Zhen, primary, Lv, Deguan, primary, Wang, Xujun, primary, Kim, Leo J.Y., primary, Zhu, Zhe, primary, Jones, Katherine A., primary, Zheng, Ye, primary, Wang, Xiuxing, primary, Siqueira-Neto, Jair L., primary, Chavez, Lukas, primary, Fu, Xiang-Dong, primary, Spruck, Charles, primary, and Rich, Jeremy N., primary

Published
2023
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16. Supplementary Figures and Legends from Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells

Author

Qiu, Zhixin, primary, Zhao, Linjie, primary, Shen, Jia Z., primary, Liang, Zhengyu, primary, Wu, Qiulian, primary, Yang, Kailin, primary, Min, Lihua, primary, Gimple, Ryan C., primary, Yang, Qiyuan, primary, Bhargava, Shruti, primary, Jin, Chunyu, primary, Kim, Cheryl, primary, Hinz, Denise, primary, Dixit, Deobrat, primary, Bernatchez, Jean A., primary, Prager, Briana C., primary, Zhang, Guoxin, primary, Dong, Zhen, primary, Lv, Deguan, primary, Wang, Xujun, primary, Kim, Leo J.Y., primary, Zhu, Zhe, primary, Jones, Katherine A., primary, Zheng, Ye, primary, Wang, Xiuxing, primary, Siqueira-Neto, Jair L., primary, Chavez, Lukas, primary, Fu, Xiang-Dong, primary, Spruck, Charles, primary, and Rich, Jeremy N., primary

Published
2023
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17. Data from Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells

Author

Qiu, Zhixin, primary, Zhao, Linjie, primary, Shen, Jia Z., primary, Liang, Zhengyu, primary, Wu, Qiulian, primary, Yang, Kailin, primary, Min, Lihua, primary, Gimple, Ryan C., primary, Yang, Qiyuan, primary, Bhargava, Shruti, primary, Jin, Chunyu, primary, Kim, Cheryl, primary, Hinz, Denise, primary, Dixit, Deobrat, primary, Bernatchez, Jean A., primary, Prager, Briana C., primary, Zhang, Guoxin, primary, Dong, Zhen, primary, Lv, Deguan, primary, Wang, Xujun, primary, Kim, Leo J.Y., primary, Zhu, Zhe, primary, Jones, Katherine A., primary, Zheng, Ye, primary, Wang, Xiuxing, primary, Siqueira-Neto, Jair L., primary, Chavez, Lukas, primary, Fu, Xiang-Dong, primary, Spruck, Charles, primary, and Rich, Jeremy N., primary

Published
2023
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18. Supplementary Data from The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells

Author

Dixit, Deobrat, primary, Prager, Briana C., primary, Gimple, Ryan C., primary, Poh, Hui Xian, primary, Wang, Yang, primary, Wu, Qiulian, primary, Qiu, Zhixin, primary, Kidwell, Reilly L., primary, Kim, Leo J.Y., primary, Xie, Qi, primary, Vitting-Seerup, Kristoffer, primary, Bhargava, Shruti, primary, Dong, Zhen, primary, Jiang, Li, primary, Zhu, Zhe, primary, Hamerlik, Petra, primary, Jaffrey, Samie R., primary, Zhao, Jing Crystal, primary, Wang, Xiuxing, primary, and Rich, Jeremy N., primary

Published
2023
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19. Supplementary Data 1 from The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies

Author

Prager, Briana C., primary, Vasudevan, Harish N., primary, Dixit, Deobrat, primary, Bernatchez, Jean A., primary, Wu, Qiulian, primary, Wallace, Lisa C., primary, Bhargava, Shruti, primary, Lee, Derrick, primary, King, Bradley H., primary, Morton, Andrew R., primary, Gimple, Ryan C., primary, Pekmezci, Melike, primary, Zhu, Zhe, primary, Siqueira-Neto, Jair L., primary, Wang, Xiuxing, primary, Xie, Qi, primary, Chen, Clark, primary, Barnett, Gene H., primary, Vogelbaum, Michael A., primary, Mack, Stephen C., primary, Chavez, Lukas, primary, Perry, Arie, primary, Raleigh, David R., primary, and Rich, Jeremy N., primary

Published
2023
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20. Supplementary methods from Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

Author

Dong, Zhen, primary, Zhang, Guoxin, primary, Qu, Meng, primary, Gimple, Ryan C., primary, Wu, Qiulian, primary, Qiu, Zhixin, primary, Prager, Briana C., primary, Wang, Xiuxing, primary, Kim, Leo J.Y., primary, Morton, Andrew R., primary, Dixit, Deobrat, primary, Zhou, Wenchao, primary, Huang, Haidong, primary, Li, Bin, primary, Zhu, Zhe, primary, Bao, Shideng, primary, Mack, Stephen C., primary, Chavez, Lukas, primary, Kay, Steve A., primary, and Rich, Jeremy N., primary

Published
2023
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21. Data from Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

Author

Dong, Zhen, primary, Zhang, Guoxin, primary, Qu, Meng, primary, Gimple, Ryan C., primary, Wu, Qiulian, primary, Qiu, Zhixin, primary, Prager, Briana C., primary, Wang, Xiuxing, primary, Kim, Leo J.Y., primary, Morton, Andrew R., primary, Dixit, Deobrat, primary, Zhou, Wenchao, primary, Huang, Haidong, primary, Li, Bin, primary, Zhu, Zhe, primary, Bao, Shideng, primary, Mack, Stephen C., primary, Chavez, Lukas, primary, Kay, Steve A., primary, and Rich, Jeremy N., primary

Published
2023
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22. Data from The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells

Author

Dixit, Deobrat, primary, Prager, Briana C., primary, Gimple, Ryan C., primary, Poh, Hui Xian, primary, Wang, Yang, primary, Wu, Qiulian, primary, Qiu, Zhixin, primary, Kidwell, Reilly L., primary, Kim, Leo J.Y., primary, Xie, Qi, primary, Vitting-Seerup, Kristoffer, primary, Bhargava, Shruti, primary, Dong, Zhen, primary, Jiang, Li, primary, Zhu, Zhe, primary, Hamerlik, Petra, primary, Jaffrey, Samie R., primary, Zhao, Jing Crystal, primary, Wang, Xiuxing, primary, and Rich, Jeremy N., primary

Published
2023
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23. Supplementary Table 2 from The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells

Author

Dixit, Deobrat, primary, Prager, Briana C., primary, Gimple, Ryan C., primary, Poh, Hui Xian, primary, Wang, Yang, primary, Wu, Qiulian, primary, Qiu, Zhixin, primary, Kidwell, Reilly L., primary, Kim, Leo J.Y., primary, Xie, Qi, primary, Vitting-Seerup, Kristoffer, primary, Bhargava, Shruti, primary, Dong, Zhen, primary, Jiang, Li, primary, Zhu, Zhe, primary, Hamerlik, Petra, primary, Jaffrey, Samie R., primary, Zhao, Jing Crystal, primary, Wang, Xiuxing, primary, and Rich, Jeremy N., primary

Published
2023
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24. Supplementary Table 1 from The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells

Author

Dixit, Deobrat, primary, Prager, Briana C., primary, Gimple, Ryan C., primary, Poh, Hui Xian, primary, Wang, Yang, primary, Wu, Qiulian, primary, Qiu, Zhixin, primary, Kidwell, Reilly L., primary, Kim, Leo J.Y., primary, Xie, Qi, primary, Vitting-Seerup, Kristoffer, primary, Bhargava, Shruti, primary, Dong, Zhen, primary, Jiang, Li, primary, Zhu, Zhe, primary, Hamerlik, Petra, primary, Jaffrey, Samie R., primary, Zhao, Jing Crystal, primary, Wang, Xiuxing, primary, and Rich, Jeremy N., primary

Published
2023
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25. Data from The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies

Author

Prager, Briana C., primary, Vasudevan, Harish N., primary, Dixit, Deobrat, primary, Bernatchez, Jean A., primary, Wu, Qiulian, primary, Wallace, Lisa C., primary, Bhargava, Shruti, primary, Lee, Derrick, primary, King, Bradley H., primary, Morton, Andrew R., primary, Gimple, Ryan C., primary, Pekmezci, Melike, primary, Zhu, Zhe, primary, Siqueira-Neto, Jair L., primary, Wang, Xiuxing, primary, Xie, Qi, primary, Chen, Clark, primary, Barnett, Gene H., primary, Vogelbaum, Michael A., primary, Mack, Stephen C., primary, Chavez, Lukas, primary, Perry, Arie, primary, Raleigh, David R., primary, and Rich, Jeremy N., primary

Published
2023
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26. Supplementary reagents from Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

Author

Dong, Zhen, primary, Zhang, Guoxin, primary, Qu, Meng, primary, Gimple, Ryan C., primary, Wu, Qiulian, primary, Qiu, Zhixin, primary, Prager, Briana C., primary, Wang, Xiuxing, primary, Kim, Leo J.Y., primary, Morton, Andrew R., primary, Dixit, Deobrat, primary, Zhou, Wenchao, primary, Huang, Haidong, primary, Li, Bin, primary, Zhu, Zhe, primary, Bao, Shideng, primary, Mack, Stephen C., primary, Chavez, Lukas, primary, Kay, Steve A., primary, and Rich, Jeremy N., primary

Published
2023
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27. Supplementary Table 3 from The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells

Author

Dixit, Deobrat, primary, Prager, Briana C., primary, Gimple, Ryan C., primary, Poh, Hui Xian, primary, Wang, Yang, primary, Wu, Qiulian, primary, Qiu, Zhixin, primary, Kidwell, Reilly L., primary, Kim, Leo J.Y., primary, Xie, Qi, primary, Vitting-Seerup, Kristoffer, primary, Bhargava, Shruti, primary, Dong, Zhen, primary, Jiang, Li, primary, Zhu, Zhe, primary, Hamerlik, Petra, primary, Jaffrey, Samie R., primary, Zhao, Jing Crystal, primary, Wang, Xiuxing, primary, and Rich, Jeremy N., primary

Published
2023
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28. Supplementary figures and legends from Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

Author

Dong, Zhen, primary, Zhang, Guoxin, primary, Qu, Meng, primary, Gimple, Ryan C., primary, Wu, Qiulian, primary, Qiu, Zhixin, primary, Prager, Briana C., primary, Wang, Xiuxing, primary, Kim, Leo J.Y., primary, Morton, Andrew R., primary, Dixit, Deobrat, primary, Zhou, Wenchao, primary, Huang, Haidong, primary, Li, Bin, primary, Zhu, Zhe, primary, Bao, Shideng, primary, Mack, Stephen C., primary, Chavez, Lukas, primary, Kay, Steve A., primary, and Rich, Jeremy N., primary

Published
2023
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29. Supplementary table S1 from Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

Author

Dong, Zhen, primary, Zhang, Guoxin, primary, Qu, Meng, primary, Gimple, Ryan C., primary, Wu, Qiulian, primary, Qiu, Zhixin, primary, Prager, Briana C., primary, Wang, Xiuxing, primary, Kim, Leo J.Y., primary, Morton, Andrew R., primary, Dixit, Deobrat, primary, Zhou, Wenchao, primary, Huang, Haidong, primary, Li, Bin, primary, Zhu, Zhe, primary, Bao, Shideng, primary, Mack, Stephen C., primary, Chavez, Lukas, primary, Kay, Steve A., primary, and Rich, Jeremy N., primary

Published
2023
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30. Supplementary Information from The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies

Author

Prager, Briana C., primary, Vasudevan, Harish N., primary, Dixit, Deobrat, primary, Bernatchez, Jean A., primary, Wu, Qiulian, primary, Wallace, Lisa C., primary, Bhargava, Shruti, primary, Lee, Derrick, primary, King, Bradley H., primary, Morton, Andrew R., primary, Gimple, Ryan C., primary, Pekmezci, Melike, primary, Zhu, Zhe, primary, Siqueira-Neto, Jair L., primary, Wang, Xiuxing, primary, Xie, Qi, primary, Chen, Clark, primary, Barnett, Gene H., primary, Vogelbaum, Michael A., primary, Mack, Stephen C., primary, Chavez, Lukas, primary, Perry, Arie, primary, Raleigh, David R., primary, and Rich, Jeremy N., primary

Published
2023
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33. Supplementary Figure from β2-Microglobulin Maintains Glioblastoma Stem Cells and Induces M2-like Polarization of Tumor-Associated Macrophages

Author

Li, Daqi, primary, Zhang, Qian, primary, Li, Lu, primary, Chen, Kexin, primary, Yang, Junlei, primary, Dixit, Deobrat, primary, Gimple, Ryan C., primary, Ci, Shusheng, primary, Lu, Chenfei, primary, Hu, Lang, primary, Gao, Jiancheng, primary, Shan, Danyang, primary, Li, Yangqing, primary, Zhang, Junxia, primary, Shi, Zhumei, primary, Gu, Danling, primary, Yuan, Wei, primary, Wu, Qiulian, primary, Yang, Kailin, primary, Zhao, Linjie, primary, Qiu, Zhixin, primary, Lv, Deguang, primary, Gao, Wei, primary, Yang, Hui, primary, Lin, Fan, primary, Wang, Qianghu, primary, Man, Jianghong, primary, Li, Chaojun, primary, Tao, Weiwei, primary, Agnihotri, Sameer, primary, Qian, Xu, primary, Shi, Yu, primary, You, Yongping, primary, Zhang, Nu, primary, Rich, Jeremy N., primary, and Wang, Xiuxing, primary

Published
2023
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35. SREBP2 maintains glioblastoma stem cells through keeping the balance between cholesterol biosynthesis and uptake

Author

Gu, Danling, primary, Zhou, Fengqi, additional, You, Hao, additional, Gao, Jiancheng, additional, Kang, Tao, additional, Dixit, Deobrat, additional, Wu, Qiulian, additional, Yang, Kailin, additional, Ci, Shusheng, additional, Shan, Danyang, additional, Fan, Xiao, additional, Yuan, Wei, additional, Zhang, Qian, additional, Lu, Chenfei, additional, Li, Daqi, additional, Zhao, Ningwei, additional, Shi, Zhumei, additional, Gao, Wei, additional, Lin, Fan, additional, Man, Jianghong, additional, Wang, Qianghu, additional, Qian, Xu, additional, Mack, Stephen C, additional, Tao, Weiwei, additional, Agnihotri, Sameer, additional, Zhang, Nu, additional, You, Yongping, additional, Rich, Jeremy N, additional, Zhang, Junxia, additional, and Wang, Xiuxing, additional

Published
2023
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36. Sorting-nexin-10 sustains platelet-derived growth factor receptor signaling in glioblastoma stem cells via endosomal protein sorting

Author

Gimple, Ryan C., primary, Zhang, Guoxin, additional, Wang, Shuai, additional, Huang, Tengfei, additional, Lee, Jina, additional, Taori, Suchet, additional, Lv, Deguan, additional, Dixit, Deobrat, additional, Halbert, Matthew E., additional, Morton, Andrew R., additional, Kidwell, Reilly L., additional, Dong, Zhen, additional, Prager, Briana C., additional, Kim, Leo, additional, Qiu, Zhixin, additional, Zhao, Linjie, additional, Xie, Qi, additional, Wu, Qiulian, additional, Agnihotri, Sameer, additional, and Rich, Jeremy N., additional

Published
2023
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37. Transcription elongation factors represent in vivo cancer dependencies in glioblastoma

Author

Miller, Tyler E., Liau, Brian B., Wallace, Lisa C., Morton, Andrew R., Xie, Qi, Dixit, Deobrat, Factor, Daniel C., Kim, Leo J. Y., Morrow, James J., Wu, Qiulian, Mack, Stephen C., Hubert, Christopher G., Gillespie, Shawn M., Flavahan, William A., Hoffmann, Thomas, Thummalapalli, Rohit, Hemann, Michael T., Paddison, Patrick J., Horbinski, Craig M., Zuber, Johannes, Scacheri, Peter C., Bernstein, Bradley E., Tesar, Paul J., and Rich, Jeremy N.

Published
2017
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39. β2-Microglobulin Maintains Glioblastoma Stem Cells and Induces M2-like Polarization of Tumor-Associated Macrophages

Author

Li, Daqi, primary, Zhang, Qian, additional, Li, Lu, additional, Chen, Kexin, additional, Yang, Junlei, additional, Dixit, Deobrat, additional, Gimple, Ryan C., additional, Ci, Shusheng, additional, Lu, Chenfei, additional, Hu, Lang, additional, Gao, Jiancheng, additional, Shan, Danyang, additional, Li, Yangqing, additional, Zhang, Junxia, additional, Shi, Zhumei, additional, Gu, Danling, additional, Yuan, Wei, additional, Wu, Qiulian, additional, Yang, Kailin, additional, Zhao, Linjie, additional, Qiu, Zhixin, additional, Lv, Deguang, additional, Gao, Wei, additional, Yang, Hui, additional, Lin, Fan, additional, Wang, Qianghu, additional, Man, Jianghong, additional, Li, Chaojun, additional, Tao, Weiwei, additional, Agnihotri, Sameer, additional, Qian, Xu, additional, Shi, Yu, additional, You, Yongping, additional, Zhang, Nu, additional, Rich, Jeremy N., additional, and Wang, Xiuxing, additional

Published
2022
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43. Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells

Author

Qiu, Zhixin, primary, Zhao, Linjie, additional, Shen, Jia Z., additional, Liang, Zhengyu, additional, Wu, Qiulian, additional, Yang, Kailin, additional, Min, Lihua, additional, Gimple, Ryan C., additional, Yang, Qiyuan, additional, Bhargava, Shruti, additional, Jin, Chunyu, additional, Kim, Cheryl, additional, Hinz, Denise, additional, Dixit, Deobrat, additional, Bernatchez, Jean A., additional, Prager, Briana C., additional, Zhang, Guoxin, additional, Dong, Zhen, additional, Lv, Deguan, additional, Wang, Xujun, additional, Kim, Leo J.Y., additional, Zhu, Zhe, additional, Jones, Katherine A., additional, Zheng, Ye, additional, Wang, Xiuxing, additional, Siqueira-Neto, Jair L., additional, Chavez, Lukas, additional, Fu, Xiang-Dong, additional, Spruck, Charles, additional, and Rich, Jeremy N., additional

Published
2022
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44. Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases

Author

Dixit, Deobrat, primary, Prager, Briana C., additional, Gimple, Ryan C., additional, Miller, Tyler E., additional, Wu, Qiulian, additional, Yomtoubian, Shira, additional, Kidwell, Reilly L., additional, Lv, Deguan, additional, Zhao, Linjie, additional, Qiu, Zhixin, additional, Zhang, Guoxin, additional, Lee, Derrick, additional, Park, Donglim Esther, additional, Wechsler-Reya, Robert J., additional, Wang, Xiuxing, additional, Bao, Shideng, additional, and Rich, Jeremy N., additional

Published
2022
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