43 results on '"Distler, Jörg Hw"'
Search Results
2. Prediction of improvement in skin fibrosis in diffuse cutaneous systemic sclerosis: a EUSTAR analysis
- Author
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Dobrota, Rucsandra, Maurer, Britta, Graf, Nicole, Jordan, Suzana, Mihai, Carina, Kowal-Bielecka, Otylia, Allanore, Yannick, Distler, Oliver, Cerinic, Marco Matucci, Guiducci, Serena, Walker, Ulrich, Lapadula, Giovanni, Iannone, Florenzo, Becvar, Radim, Sierakowsky, Stanislaw, Cutolo, Maurizio, Sulli, Alberto, Valentini, Gabriele, Cuomo, Giovanna, Vettori, Serena, Riemekasten, Gabriela, Siegert, Elise, Rednic, Simona, Nicoara, Ileana, Kahan, André, Vlachoyiannopoulos, P., Montecucco, C., Caporali, Roberto, Carreira, Patricia E., Novak, Srdan, Czirják, László, Varju, Cecilia, Chizzolini, Carlo, Kucharz, Eugene J., Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Cozzi, Franco, Rozman, Blaz, Mallia, Carmel, Coleiro, Bernard, Gabrielli, Armando, Farge, Dominique, Wu, Chen, Marjanovic, Zora, Faivre, Helene, Hij, Darin, Dhamadi, Roza, Airò, Paolo, Hesselstrand, Roger, Wollheim, Frank, Wuttge, Dirk M, Andréasson, Kristofer, Martinovic, Duska, Balbir-Gurman, Alexandra, Braun-Moscovici, Yolanda, Trotta, F., Lo Monaco, Andrea, Hunzelmann, Nicolas, Pellerito, Raffaele, Mauriziano, Ospedale, Bambara, Lisa Maria, Caramaschi, Paola, Black, Carol, Denton, Christopher, Damjanov, Nemanja, Henes, Jörg, Ortiz Santamaria, Vera, Heitmann, Stefan, Krasowska, Dorota, Seidel, Matthias, Burkhardt, Harald, Himsel, Andrea, Salvador, Maria J., Silva, José Antonio Pereira Da, Stamenkovic, Bojana, Stankovic, Aleksandra, Banja, Niska, Tikly, Mohammed, Ananieva, Lidia P., Denisov, Lev N., Müller-Ladner, Ulf, Frerix, Marc, Tarner, Ingo, Scorza, Raffaella, Clinica, U.O. Immunologia, Engelhart, Merete, Strauss, Gitte, Nielsen, Henrik, Damgaard, Kirsten, Mendoza, Antonio Zea, de la Puente, Carlos, Giraldo, Walter A. Sifuentes, Midtvedt, Øyvind, Reiseter, Silje, Hachulla, Eric, Launay, David, Valesini, Guido, Riccieri, Valeria, Ionescu, Ruxandra Maria, Opris, Daniela, Groseanu, Laura, Cornateanu, Roxana Sfrent, Ionitescu, Razvan, Gherghe, Ana Maria, Soare, Alina, Gorga, Marilena, Bojinca, Mihai, Schett, Georg, Distler, Jörg HW, Beyer, Christian, Meroni, Pierluigi, Ingegnoli, Francesca, Mouthon, Luc, De Keyser, Filip, Smith, Vanessa, Cantatore, Francesco P., Corrado, Ada, Pozzi, Maria R., Eyerich, Kilian, Hein, Rüdiger, Knott, Elisabeth, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Madej, Marta, Krummel-Lorenz, Brigitte, Aringer, Martin, Günther, Claudia, Westhovens, Rene, de Langhe, Ellen, Lenaerts, Jan, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Radominski, Sebastião C., de Souza Müller, Carolina, Azevedo, Valderílio F., Agachi, Svetlana, Groppa, Liliana, Chiaburu, Lealea, Russu, Eugen, Popa, Sergei, Zenone, Thierry, Highton, John, Stamp, Lisa, Chapman, Peter, O’Donnell, John, Solanki, Kamal, Veale, Douglas, OʼRourke, Marie, Loyo, Esthela, Li, Mengtao, Rosato, Edoardo, Amoroso, Antonio, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Foti, Rosario, Chirieac, Rodica, Ancuta, Codrina, Villiger, Peter, Adler, Sabine, Sibilia, Jean, Chatelus, Emmanuel, Gottenberg, Jacques Eric, Chifflot, Hélène, Litinsky, Ira, Venalis, Algirdas, Butrimiene, Irena, Venalis, Paulius, Rugiene, Rita, Karpec, Diana, Saketkoo, Lesley Ann, Lasky, Joseph A., Kerzberg, Eduardo, Montoya, Fabiana, Cosentino, Vanesa, Limonta, Massimiliano, Brucato, Antonio Luca, Lupi, Elide, Spertini, François, Ribi, Camillo, Buss, Guillaume, Pasquali, Jean Louis, Martin, Thierry, and Gorse, Audrey
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- 2016
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3. Nintedanib in patients with systemic sclerosis-associated interstitial lung disease: subgroup analyses by autoantibody status and skin score
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Kuwana, Masataka, Allanore, Yannick, Denton, Christopher P, Distler, Jörg Hw, Steen, Virginia, Khanna, Dinesh, Matucci-Cerinic, Marco, Mayes, Maureen D, Volkmann, Elizabeth R, Miede, Corinna, Gahlemann, Martina, Quaresma Lic, Manuel, Alves, Margarida, Distler, Oliver, and University of Zurich
- Subjects
10051 Rheumatology Clinic and Institute of Physical Medicine ,610 Medicine & health - Published
- 2022
4. Nintedanib in patients with systemic sclerosis-associated interstitial lung disease: subgroup analyses by autoantibody status and skin score
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Kuwana, Masataka; https://orcid.org/0000-0001-8352-6136, Allanore, Yannick; https://orcid.org/0000-0002-6149-0002, Denton, Christopher P; https://orcid.org/0000-0003-3975-8938, Distler, Jörg Hw, Steen, Virginia, Khanna, Dinesh; https://orcid.org/0000-0003-1412-4453, Matucci-Cerinic, Marco; https://orcid.org/0000-0002-9324-3161, Mayes, Maureen D; https://orcid.org/0000-0001-5070-2535, Volkmann, Elizabeth R; https://orcid.org/0000-0003-3750-6569, Miede, Corinna, Gahlemann, Martina, Quaresma Lic, Manuel, Alves, Margarida, Distler, Oliver; https://orcid.org/0000-0002-0546-8310, Kuwana, Masataka; https://orcid.org/0000-0001-8352-6136, Allanore, Yannick; https://orcid.org/0000-0002-6149-0002, Denton, Christopher P; https://orcid.org/0000-0003-3975-8938, Distler, Jörg Hw, Steen, Virginia, Khanna, Dinesh; https://orcid.org/0000-0003-1412-4453, Matucci-Cerinic, Marco; https://orcid.org/0000-0002-9324-3161, Mayes, Maureen D; https://orcid.org/0000-0001-5070-2535, Volkmann, Elizabeth R; https://orcid.org/0000-0003-3750-6569, Miede, Corinna, Gahlemann, Martina, Quaresma Lic, Manuel, Alves, Margarida, and Distler, Oliver; https://orcid.org/0000-0002-0546-8310
- Abstract
OBJECTIVE: We used data from the SENSCIS trial to assess the effects of nintedanib versus placebo in subgroups of patients with SSc-ILD based on characteristics associated with progression of SSc-ILD in previous studies. METHODS: Patients with SSc-ILD were randomized to receive nintedanib or placebo, stratified by anti-topoisomerase I antibody (ATA) status. We assessed the rate of decline in forced vital capacity (FVC) (mL/year) over 52 weeks in subgroups by baseline ATA status, modified Rodnan skin score (mRSS) (<18 versus ≥18), and SSc subtype (limited cutaneous SSc [lcSSc] versus diffuse cutaneous SSc [dcSSc]). RESULTS: At baseline, of 576 patients treated, 60.8% were ATA-positive, 51.9% had dcSSc, and 77.5% of 574 patients with mRSS data available had mRSS <18. The effect of nintedanib versus placebo on reducing the rate of decline in FVC (mL/year) was numerically more pronounced in patients who were ATA-negative (difference: 57.2 [95% CI -3.5, 118.0]) than ATA-positive (difference: 29.9 [-19.1, 78.8]), in patients who had mRSS ≥18 (difference: 88.7 [7.7, 169.8]) than mRSS <18 at baseline (difference: 26.4 [-16.8, 69.6]), and in patients with dcSSc (difference: 56.6 [3.2, 110.0]) than lcSSc (difference: 25.3 [-28.9, 79.6]), but exploratory interaction P values did not indicate heterogeneity in the effect of nintedanib versus placebo between these subgroups (P > 0.05 for all). CONCLUSION: In patients with SSc-ILD, no heterogeneity was detected in the treatment effect of nintedanib in reducing the annual rate of decline in FVC across subgroups based on ATA status, mRSS, and SSc subtype.
- Published
- 2022
5. Platelet phagocytosis via PSGL1 and accumulation of microparticles in systemic sclerosis
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Manfredi, Angelo A, Ramirez, Giuseppe A, Godino, Cosmo, Capobianco, Annalisa, Monno, Antonella, Franchini, Stefano, Tombetti, Enrico, Corradetti, Sara, Distler, Jörg Hw, Bianchi, Marco E, Rovere-Querini, Patrizia, Maugeri, Norma, Manfredi, Angelo A, Ramirez, Giuseppe A, Godino, Cosmo, Capobianco, Annalisa, Monno, Antonella, Franchini, Stefano, Tombetti, Enrico, Corradetti, Sara, Distler, Jörg Hw, Bianchi, Marco E, Rovere-Querini, Patrizia, and Maugeri, Norma
- Abstract
It is unclear why activated platelets and platelet-derived microparticles (µPs) accumulate in the blood of patients with systemic sclerosis (SSc). Here we investigated whether defective phagocytosis might contribute.
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- 2021
6. Inactivation of autophagy ameliorates glucocorticoid-induced and ovariectomy-induced bone loss
- Author
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Lin, Neng-Yu, Chen, Chih-Wei, Kagwiria, Rosebeth, Liang, Ruifang, Beyer, Christian, Distler, Alfiya, Luther, Julia, Engelke, Klaus, Schett, Georg, and Distler, Jörg HW
- Published
- 2016
- Full Text
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7. A gender gap in primary and secondary heart dysfunctions in systemic sclerosis: a EUSTAR prospective study
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Elhai, Muriel, Avouac, Jérôme, Walker, Ulrich A, Matucci-Cerinic, Marco, Riemekasten, Gabriela, Airò, Paolo, Hachulla, Eric, Valentini, Gabriele, Carreira, Patricia E, Cozzi, Franco, Balbir Gurman, Alexandra, Braun-Moscovici, Yolanda, Damjanov, Nemanja, Ananieva, Lidia P, Scorza, Raffaella, Jimenez, Sergio, Busquets, Joanna, Li, Mengtao, Müller-Ladner, Ulf, Kahan, André, Distler, Oliver, Allanore, Yannick, Guiducci, Serena, Tyndall, Alan, Lapadula, Giovanni, Iannone, Florenzo, Becvar, Radim, Sierakowsky, Stanislaw, Bielecka, Otylia Kowal, Cutolo, Maurizio, Sulli, Alberto, Cuomo, Giovanna, Vettori, Serena, Rednic, Simona, Nicoara, Ileana, Vlachoyiannopoulos, P., Montecucco, C., Caporali, Roberto, Novak, Srdan, Czirják, László, Varju, Cecilia, Chizzolini, Carlo, Kucharz, Eugene J., Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Rozman, Blaz, Mallia, Carmel, Coleiro, Bernard, Gabrielli, Armando, Farge, Dominique, Hij, Adrian, Hesselstrand, Roger, Scheja, Agneta, Wollheim, Frank, Martinovic, Duska, Govoni, M., Monaco, Andrea Lo, Hunzelmann, Nicolas, Pellerito, Raffaele, Bambara, Lisa Maria, Caramaschi, Paola, Black, Carol, Denton, Christopher, Henes, Jörg, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Seidel, Matthias, Oleszowsky, Mara, Burkhardt, Harald, Himsel, Andrea, Salvador, Maria J., Stamenkovic, Bojana, Stankovic, Aleksandra, Tikly, Mohammed, Starovoytova, Maya N., Engelhart, Merete, Strauss, Gitte, Nielsen, Henrik, Damgaard, Kirsten, Szücs, Gabriella, Zea Mendoza, Antonio, de la Puente Buijdos, Carlos, Sifuentes Giraldo, Walter A., Midtvedt, Øyvind, Garen, Torhild, Launay, David, Valesini, Guido, Riccieri, Valeria, Ionescu, Ruxandra Maria, Opris, Daniela, Groseanu, Laura, Wigley, Fredrick M., Mihai, Carmen M., Cornateanu, Roxana Sfrent, Ionitescu, Razvan, Gherghe, Ana Maria, Gorga, Marilena, Dobrota, Rucsandra, Bojinca, Mihai, Schett, Georg, Distler, Jörg HW, Meroni, Pierluigi, Zeni, Silvana, Mouthon, Luc, Keyser, Filip De, Smith, Vanessa, Cantatore, Francesco P., Corrado, Ada, Ullman, Susanne, Iversen, Line, Pozzi, Maria R., Eyerich, Kilian, Hein, Rüdiger, Knott, Elisabeth, Szechinski, Jacek, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Krummel-Lorenz, Brigitte, Saar, Petra, Aringer, Martin, Günther, Claudia, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Radominski, Sebastião C., Müller, Carolina de Souza, Azevedo, Valderílio F., Agachi, Svetlana, Groppa, Liliana, Chiaburu, Lealea, Russu, Eugen, Zenone, Thierry, Stebbings, Simon, Highton, John, Stamp, Lisa, Chapman, Peter, Baron, Murray, OʼDonnell, John, Solanki, Kamal, Doube, Alan, Veale, Douglas, OʼRourke, Marie, Loyo, Esthela, Rosato, Edoardo, Pisarri, Simonetta, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Chirieac, Rodica, Ancuta, Codrina, Furst, Daniel E., Kafaja, Suzanne, Lefebvre, Paloma García de la Peña, Rubio, Silvia Rodriguez, Exposito, Marta Valero, Sibilia, Jean, Chatelus, Emmanuel, Gottenberg, Jacques Eric, Chifflot, Hélène, Litinsky, Ira, Venalis, Algirdas, Butrimiene, Irena, Venalis, Paulius, Rugiene, Rita, Karpec, Diana, Kerzberg, Eduardo, Montoya, Fabiana, and Cosentino, Vanesa
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- 2016
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8. Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages
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Beyer, Christian, Huang, Jingang, Beer, Jürgen, Zhang, Yun, Palumbo-Zerr, Katrin, Zerr, Pawel, Distler, Alfiya, Dees, Clara, Maier, Christiane, Munoz, Louis, Krönke, Gerhard, Uderhardt, Stefan, Distler, Oliver, Jones, Simon, Rose-John, Stefan, Oravecz, Tamas, Schett, Georg, and Distler, Jörg HW
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- 2015
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9. Prediction of worsening of skin fibrosis in patients with diffuse cutaneous systemic sclerosis using the EUSTAR database
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Maurer, Britta, Graf, Nicole, Michel, Beat A, Müller-Ladner, Ulf, Czirják, László, Denton, Christopher P, Tyndall, Alan, Metzig, Carola, Lanius, Vivian, Khanna, Dinesh, Distler, Oliver, Tarner, Ingo H, Cerinic, Marco Matucci, Guiducci, Serena, Walker, Ulrich, Lapadula, Giovanni, Iannone, Florenzo, Becvar, Radim, Sierakowsky, Stanislaw, Bielecka, Otylia Kowal, Cutolo, Maurizio, Sulli, Alberto, Valentini, Gabriele, Cuomo, Giovanna, Vettori, Serena, Riemekasten, Gabriele, Rednic, Simona, Nicoara, Ileana, Kahan, André, Allanore, Yannick, Vlachoyiannopoulos, P, Montecucco, C, Caporali, Roberto, Carreira, Patricia E, Novak, Srdan, Varju, Cecilia, Chizzolini, Carlo, Kucharz, Eugene J, Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Cozzi, Franco, Rozman, Blaz, Mallia, Carmel, Coleiro, Bernard, Gabrielli, Armando, Farge, Dominique, Hij, Adrian, Airò, Paolo, Hesselstrand, Roger, Scheja, Agneta, Wollheim, Frank, Martinovic, Duska, Gurman, Alexandra Balbir, Braun-Moscovici, Yolanda, Govoni, M, Monaco, Andrea Lo, Hunzelmann, Nicolas, Pellerito, Raffaele, Bambara, Lisa Maria, Caramaschi, Paola, Black, Carol, Damjanov, Nemanja, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Seidel, Matthias, Oleszowsky, Mara, Burkhardt, Harald, Himsel, Andrea, Salvador, Maria J, Stamenkovic, Bojana, Stankovic, Aleksandra, Tikly, Mohammed, Starovoytova, Maya N, Ananieva, Lidia P, Scorza, Raffaella, Engelhart, Merete, Strauss, Gitte, Nielsen, Henrik, Damgaard, Kirsten, Szücs, Gabriella, Mendoza, Antonio Zea, Buijdos, Carlos de la Puente, Sifuentes Giraldo, Walter A., Midtvedt, Øyvind, Garen, Torhild, Hachulla, Eric, Launay, David, Valesini, Guido, Riccieri, Valeria, Ionescu, Ruxandra Maria, Opris, Daniela, Groseanu, Laura, Wigley, Fredrick M, Mihai, Carmen M, Cornateanu, Roxana Sfrent, Ionitescu, Razvan, Gherghe, Ana Maria, Gorga, Marilena, Dobrota, Rucsandra, Bojinca, Mihai, Schett, Georg, Distler, Jörg HW, Meroni, Pierluigi, Zeni, Silvana, Mouthon, Luc, Keyser, Filip De, Cantatore, Francesco P, Corrado, Ada, Ullman, Susanne, Iversen, Line, Pozzi, Maria R, Eyerich, Kilian, Hein, Rüdiger, Knott, Elisabeth, Szechinski, Jacek, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Krummel-Lorenz, Brigitte, Saar, Petra, Aringer, Martin, Günther, Claudia, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Radominski, Sebastião C, Müller, Carolina de Souza, Azevedo, Valderílio F, Agachi, Svetlana, Groppa, Liliana, Chiaburu, Lealea, Russu, Eugen, Zenone, Thierry, Highton, John, Stamp, Lisa, Chapman, Peter, OʼDonnell, John, Solanki, Kamal, Doube, Alan, Veale, Douglas, O’Rourke, Marie, Loyo, Esthela, Li, Mengtao, Rosato, Edoardo, Pisarri, Simonetta, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Chirieac, Rodica, Ancuta, Codrina, E Furst, Daniel, Kafaja, Suzanne, Lefebvre, Paloma García de la Peña, Rubio, Silvia Rodriguez, Exposito, Marta Valero, Sibilia, Jean, Chatelus, Emmanuel, Gottenberg, Jacques Eric, Chifflot, Hélène, Litinsky, Ira, Venalis, Algirdas, Butrimiene, Irena, Venalis, Paulius, Rugiene, Rita, Karpec, Diana, Kerzberg, Eduardo, Montoya, Fabiana, and Cosentino, Vanesa
- Published
- 2015
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10. Signature of circulating microRNAs in osteoarthritis
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Beyer, Christian, Zampetaki, Anna, Lin, Neng-Yu, Kleyer, Arnd, Perricone, Carlo, Iagnocco, Annamaria, Distler, Alfiya, Langley, Sarah R, Gelse, Kolja, Sesselmann, Stefan, Lorenzini, Rolando, Niemeier, Andreas, Swoboda, Bernd, Distler, Jörg HW, Santer, Peter, Egger, Georg, Willeit, Johann, Mayr, Manuel, Schett, Georg, and Kiechl, Stefan
- Published
- 2015
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11. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
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Klionsky, Daniel J, Abdel-Aziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen, Abeliovich, Hagai, Abildgaard, Marie H, Abudu, Yakubu Princely, Acevedo-Arozena, Abraham, Adamopoulos, Iannis E, Adeli, Khosrow, Adolph, Timon E, Adornetto, Annagrazia, Aflaki, Elma, Agam, Galila, Agarwal, Anupam, Aggarwal, Bharat B, Agnello, Maria, Agostinis, Patrizia, Agrewala, Javed N, Agrotis, Alexander, Aguilar, Patricia V, Ahmad, S Tariq, Ahmed, Zubair M, Ahumada-Castro, Ulises, Aits, Sonja, Aizawa, Shu, Akkoc, Yunus, Akoumianaki, Tonia, Akpinar, Hafize Aysin, Al-Abd, Ahmed M, Al-Akra, Lina, Al-Gharaibeh, Abeer, Alaoui-Jamali, Moulay A, Alberti, Simon, Alcocer-Gómez, Elísabet, Alessandri, Cristiano, Ali, Muhammad, Alim Al-Bari, M Abdul, Aliwaini, Saeb, Alizadeh, Javad, Almacellas, Eugènia, Almasan, Alexandru, Alonso, Alicia, Alonso, Guillermo D, Altan-Bonnet, Nihal, Altieri, Dario C, Álvarez, Élida MC, Alves, Sara, Alves Da Costa, Cristine, Alzaharna, Mazen M, Amadio, Marialaura, Amantini, Consuelo, Amaral, Cristina, Ambrosio, Susanna, Amer, Amal O, Ammanathan, Veena, An, Zhenyi, Andersen, Stig U, Andrabi, Shaida A, Andrade-Silva, Magaiver, Andres, Allen M, Angelini, Sabrina, Ann, David, Anozie, Uche C, Ansari, Mohammad Y, Antas, Pedro, Antebi, Adam, Antón, Zuriñe, Anwar, Tahira, Apetoh, Lionel, Apostolova, Nadezda, Araki, Toshiyuki, Araki, Yasuhiro, Arasaki, Kohei, Araújo, Wagner L, Araya, Jun, Arden, Catherine, Arévalo, Maria-Angeles, Arguelles, Sandro, Arias, Esperanza, Arikkath, Jyothi, Arimoto, Hirokazu, Ariosa, Aileen R, Armstrong-James, Darius, Arnauné-Pelloquin, Laetitia, Aroca, Angeles, Arroyo, Daniela S, Arsov, Ivica, Artero, Rubén, Asaro, Dalia Maria Lucia, Aschner, Michael, Ashrafizadeh, Milad, Ashur-Fabian, Osnat, Atanasov, Atanas G, Au, Alicia K, Auberger, Patrick, Auner, Holger W, Aurelian, Laure, Autelli, Riccardo, Avagliano, Laura, Ávalos, Yenniffer, Aveic, Sanja, Aveleira, Célia Alexandra, Avin-Wittenberg, Tamar, Aydin, Yucel, Ayton, Scott, Ayyadevara, Srinivas, Azzopardi, Maria, Baba, Misuzu, Backer, Jonathan M, Backues, Steven K, Bae, Dong-Hun, Bae, Ok-Nam, Bae, Soo Han, Baehrecke, Eric H, Baek, Ahruem, Baek, Seung-Hoon, Baek, Sung Hee, Bagetta, Giacinto, Bagniewska-Zadworna, Agnieszka, Bai, Hua, Bai, Jie, Bai, Xiyuan, Bai, Yidong, Bairagi, Nandadulal, Baksi, Shounak, Balbi, Teresa, Baldari, Cosima T, Balduini, Walter, Ballabio, Andrea, Ballester, Maria, Balazadeh, Salma, Balzan, Rena, Bandopadhyay, Rina, Banerjee, Sreeparna, Banerjee, Sulagna, Bánréti, Ágnes, Bao, Yan, Baptista, Mauricio S, Baracca, Alessandra, Barbati, Cristiana, Bargiela, Ariadna, Barilà, Daniela, Barlow, Peter G, Barmada, Sami J, Barreiro, Esther, Barreto, George E, Bartek, Jiri, Bartel, Bonnie, Bartolome, Alberto, Barve, Gaurav R, Basagoudanavar, Suresh H, Bassham, Diane C, Bast, Robert C, Basu, Alakananda, Batoko, Henri, Batten, Isabella, Baulieu, Etienne E, Baumgarner, Bradley L, Bayry, Jagadeesh, Beale, Rupert, Beau, Isabelle, Beaumatin, Florian, Bechara, Luiz RG, Beck, George R, Beers, Michael F, Begun, Jakob, Behrends, Christian, Behrens, Georg MN, Bei, Roberto, Bejarano, Eloy, Bel, Shai, Behl, Christian, Belaid, Amine, Belgareh-Touzé, Naïma, Bellarosa, Cristina, Belleudi, Francesca, Belló Pérez, Melissa, Bello-Morales, Raquel, Beltran, Jackeline Soares De Oliveira, Beltran, Sebastián, Benbrook, Doris Mangiaracina, Bendorius, Mykolas, Benitez, Bruno A, Benito-Cuesta, Irene, Bensalem, Julien, Berchtold, Martin W, Berezowska, Sabina, Bergamaschi, Daniele, Bergami, Matteo, Bergmann, Andreas, Berliocchi, Laura, Berlioz-Torrent, Clarisse, Bernard, Amélie, Berthoux, Lionel, Besirli, Cagri G, Besteiro, Sebastien, Betin, Virginie M, Beyaert, Rudi, Bezbradica, Jelena S, Bhaskar, Kiran, Bhatia-Kissova, Ingrid, Bhattacharya, Resham, Bhattacharya, Sujoy, Bhattacharyya, Shalmoli, Bhuiyan, Md Shenuarin, Bhutia, Sujit Kumar, Bi, Lanrong, Bi, Xiaolin, Biden, Trevor J, Bijian, Krikor, Billes, Viktor A, Binart, Nadine, Bincoletto, Claudia, Birgisdottir, Asa B, Bjorkoy, Geir, Blanco, Gonzalo, Blas-Garcia, Ana, Blasiak, Janusz, Blomgran, Robert, Blomgren, Klas, Blum, Janice S, Boada-Romero, Emilio, Boban, Mirta, Boesze-Battaglia, Kathleen, Boeuf, Philippe, Boland, Barry, Bomont, Pascale, Bonaldo, Paolo, Bonam, Srinivasa Reddy, Bonfili, Laura, Bonifacino, Juan S, Boone, Brian A, Bootman, Martin D, Bordi, Matteo, Borner, Christoph, Bornhauser, Beat C, Borthakur, Gautam, Bosch, Jürgen, Bose, Santanu, Botana, Luis M, Botas, Juan, Boulanger, Chantal M, Boulton, Michael E, Bourdenx, Mathieu, Bourgeois, Benjamin, Bourke, Nollaig M, Bousquet, Guilhem, Boya, Patricia, Bozhkov, Peter V, Bozi, Luiz HM, Bozkurt, Tolga O, Brackney, Doug E, Brandts, Christian H, Braun, Ralf J, Braus, Gerhard H, Bravo-Sagua, Roberto, Bravo-San Pedro, José M, Brest, Patrick, Bringer, Marie-Agnès, Briones-Herrera, Alfredo, Broaddus, V Courtney, Brodersen, Peter, Brodsky, Jeffrey L, Brody, Steven L, Bronson, Paola G, Bronstein, Jeff M, 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Anthony, Sinha, Sangita, Sirko, Agnieszka, Sirohi, Kapil, Sivridis, Efthimios L, Skendros, Panagiotis, Skirycz, Aleksandra, Slaninová, Iva, Smaili, Soraya S, Smertenko, Andrei, Smith, Matthew D, Soenen, Stefaan J, Sohn, Eun Jung, Sok, Sophia PM, Solaini, Giancarlo, Soldati, Thierry, Soleimanpour, Scott A, Soler, Rosa M, Solovchenko, Alexei, Somarelli, Jason A, Sonawane, Avinash, Song, Fuyong, Song, Hyun Kyu, Song, Ju-Xian, Song, Kunhua, Song, Zhiyin, Soria, Leandro R, Sorice, Maurizio, Soukas, Alexander A, Soukup, Sandra-Fausia, Sousa, Diana, Sousa, Nadia, Spagnuolo, Paul A, Spector, Stephen A, Srinivas Bharath, MM, St Clair, Daret, Stagni, Venturina, Staiano, Leopoldo, Stalnecker, Clint A, Stankov, Metodi V, Stathopulos, Peter B, Stefan, Katja, Stefan, Sven Marcel, Stefanis, Leonidas, Steffan, Joan S, Steinkasserer, Alexander, Stenmark, Harald, Sterneckert, Jared, Stevens, Craig, Stoka, Veronika, Storch, Stephan, Stork, Björn, Strappazzon, Flavie, Strohecker, Anne Marie, Stupack, Dwayne G, Su, Huanxing, Su, Ling-Yan, Su, Longxiang, Suarez-Fontes, Ana M, Subauste, Carlos S, Subbian, Selvakumar, Subirada, Paula V, Sudhandiran, Ganapasam, Sue, Carolyn M, Sui, Xinbing, Summers, Corey, Sun, Guangchao, Sun, Jun, Sun, Kang, Sun, Meng-Xiang, Sun, Qiming, Sun, Yi, Sun, Zhongjie, Sunahara, Karen KS, Sundberg, Eva, Susztak, Katalin, Sutovsky, Peter, Suzuki, Hidekazu, Sweeney, Gary, Symons, J David, Sze, Stephen Cho Wing, Szewczyk, Nathaniel J, Tabęcka-Łonczynska, Anna, Tabolacci, Claudio, Tacke, Frank, Taegtmeyer, Heinrich, Tafani, Marco, Tagaya, Mitsuo, Tai, Haoran, Tait, Stephen WG, Takahashi, Yoshinori, Takats, Szabolcs, Talwar, Priti, Tam, Chit, Tam, Shing Yau, Tampellini, Davide, Tamura, Atsushi, Tan, Chong Teik, Tan, Eng-King, Tan, Ya-Qin, Tanaka, Masaki, Tanaka, Motomasa, Tang, Daolin, Tang, Jingfeng, Tang, Tie-Shan, Tanida, Isei, Tao, Zhipeng, Taouis, Mohammed, Tatenhorst, Lars, Tavernarakis, Nektarios, Taylor, Allen, Taylor, Gregory A, Taylor, Joan M, Tchetina, Elena, Tee, Andrew R, Tegeder, Irmgard, Teis, David, Teixeira, Natercia, Teixeira-Clerc, Fatima, Tekirdag, Kumsal A, Tencomnao, Tewin, Tenreiro, Sandra, Tepikin, Alexei V, Testillano, Pilar S, Tettamanti, Gianluca, Tharaux, Pierre-Louis, Thedieck, Kathrin, Thekkinghat, Arvind A, Thellung, Stefano, Thinwa, Josephine W, Thirumalaikumar, VP, Thomas, Sufi Mary, Thomes, Paul G, Thorburn, Andrew, Thukral, Lipi, Thum, Thomas, Thumm, Michael, Tian, Ling, Tichy, Ales, Till, Andreas, Timmerman, Vincent, Titorenko, Vladimir I, Todi, Sokol V, Todorova, Krassimira, Toivonen, Janne M, Tomaipitinca, Luana, Tomar, Dhanendra, Tomas-Zapico, Cristina, Tomić, Sergej, Tong, Benjamin Chun-Kit, Tong, Chao, Tong, Xin, Tooze, Sharon A, Torgersen, Maria L, Torii, Satoru, Torres-López, Liliana, Torriglia, Alicia, Towers, Christina G, Towns, Roberto, Toyokuni, Shinya, Trajkovic, Vladimir, Tramontano, Donatella, Tran, Quynh-Giao, Travassos, Leonardo H, Trelford, Charles B, Tremel, Shirley, Trougakos, Ioannis P, Tsao, Betty P, Tschan, Mario P, Tse, Hung-Fat, Tse, Tak Fu, Tsugawa, Hitoshi, Tsvetkov, Andrey S, Tumbarello, David A, Tumtas, Yasin, Tuñón, María J, Turcotte, Sandra, Turk, Boris, Turk, Vito, Turner, Bradley J, Tuxworth, Richard I, Tyler, Jessica K, Tyutereva, Elena V, Uchiyama, Yasuo, Ugun-Klusek, Aslihan, Uhlig, Holm H, Ułamek-Kozioł, Marzena, Ulasov, Ilya V, Umekawa, Midori, Ungermann, Christian, Unno, Rei, Urbe, Sylvie, Uribe-Carretero, Elisabet, Üstün, Suayib, Uversky, Vladimir N, Vaccari, Thomas, Vaccaro, Maria I, Vahsen, Björn F, Vakifahmetoglu-Norberg, Helin, Valdor, Rut, Valente, Maria J, Valko, Ayelén, Vallee, Richard B, Valverde, Angela M, Van Den Berghe, Greet, Van Der Veen, Stijn, Van Kaer, Luc, Van Loosdregt, Jorg, Van Wijk, Sjoerd JL, Vandenberghe, Wim, Vanhorebeek, Ilse, Vannier-Santos, Marcos A, Vannini, Nicola, Vanrell, M Cristina, Vantaggiato, Chiara, Varano, Gabriele, Varela-Nieto, Isabel, Varga, Máté, Vasconcelos, M Helena, Vats, Somya, Vavvas, Demetrios G, Vega-Naredo, Ignacio, Vega-Rubin-De-Celis, Silvia, Velasco, Guillermo, Velázquez, Ariadna P, Vellai, Tibor, Vellenga, Edo, Velotti, Francesca, Verdier, Mireille, Verginis, Panayotis, Vergne, Isabelle, Verkade, Paul, Verma, Manish, Verstreken, Patrik, Vervliet, Tim, Vervoorts, Jörg, Vessoni, Alexandre T, Victor, Victor M, Vidal, Michel, Vidoni, Chiara, Vieira, Otilia V, Vierstra, Richard D, Viganó, Sonia, Vihinen, Helena, Vijayan, Vinoy, Vila, Miquel, Vilar, Marçal, Villalba, José M, Villalobo, Antonio, Villarejo-Zori, Beatriz, Villarroya, Francesc, Villarroya, Joan, Vincent, Olivier, Vindis, Cecile, Viret, Christophe, Viscomi, Maria Teresa, Visnjic, Dora, Vitale, Ilio, Vocadlo, David J, Voitsekhovskaja, Olga V, Volonté, Cinzia, Volta, Mattia, Vomero, Marta, Von Haefen, Clarissa, Vooijs, Marc A, Voos, Wolfgang, Vucicevic, Ljubica, Wade-Martins, Richard, Waguri, Satoshi, Waite, Kenrick A, Wakatsuki, Shuji, Walker, David W, Walker, Mark J, Walker, Simon A, Walter, Jochen, Wandosell, Francisco G, Wang, Bo, Wang, Chao-Yung, Wang, Chen, Wang, Chenran, Wang, Chenwei, Wang, Cun-Yu, Wang, Dong, Wang, Fangyang, Wang, Feng, Wang, Fengming, Wang, Guansong, Wang, Han, Wang, Hao, Wang, Hexiang, Wang, Hong-Gang, Wang, Jianrong, Wang, Jigang, Wang, Jiou, Wang, Jundong, Wang, Kui, Wang, Lianrong, Wang, Liming, Wang, Maggie Haitian, Wang, Meiqing, Wang, Nanbu, Wang, Pengwei, Wang, Peipei, Wang, Ping, Wang, Qing Jun, Wang, Qing, Wang, Qing Kenneth, Wang, Qiong A, Wang, Wen-Tao, Wang, Wuyang, Wang, Xinnan, Wang, Xuejun, Wang, Yan, Wang, Yanchang, Wang, Yanzhuang, Wang, Yen-Yun, Wang, Yihua, Wang, Yipeng, Wang, Yu, Wang, Yuqi, Wang, Zhe, Wang, Zhenyu, Wang, Zhouguang, Warnes, Gary, Warnsmann, Verena, Watada, Hirotaka, Watanabe, Eizo, Watchon, Maxinne, Wawrzyńska, Anna, Weaver, Timothy E, Wegrzyn, Grzegorz, Wehman, Ann M, Wei, Huafeng, Wei, Lei, Wei, Taotao, Wei, Yongjie, Weiergräber, Oliver H, Weihl, Conrad C, Weindl, Günther, Weiskirchen, Ralf, Wells, Alan, Wen, Runxia H, Wen, Xin, Werner, Antonia, Weykopf, Beatrice, Wheatley, Sally P, Whitton, J Lindsay, Whitworth, Alexander J, Wiktorska, Katarzyna, Wildenberg, Manon E, Wileman, Tom, Wilkinson, Simon, Willbold, Dieter, Williams, Brett, Williams, Robin SB, Williams, Roger L, Williamson, Peter R, Wilson, Richard A, Winner, Beate, Winsor, Nathaniel J, Witkin, Steven S, Wodrich, Harald, Woehlbier, Ute, Wollert, Thomas, Wong, Esther, Wong, Jack Ho, Wong, Richard W, Wong, Vincent Kam Wai, Wong, W Wei-Lynn, Wu, An-Guo, Wu, Chengbiao, Wu, Jian, Wu, Junfang, Wu, Kenneth K, Wu, Min, Wu, Shan-Ying, Wu, Shengzhou, Wu, Shu-Yan, Wu, Shufang, Wu, William KK, Wu, Xiaohong, Wu, Xiaoqing, Wu, Yao-Wen, Wu, Yihua, Xavier, Ramnik J, Xia, Hongguang, Xia, Lixin, Xia, Zhengyuan, Xiang, Ge, Xiang, Jin, Xiang, Mingliang, Xiang, Wei, Xiao, Bin, Xiao, Guozhi, Xiao, Hengyi, Xiao, Hong-Tao, Xiao, Jian, Xiao, Lan, Xiao, Shi, Xiao, Yin, Xie, Baoming, Xie, Chuan-Ming, Xie, Min, Xie, Yuxiang, Xie, Zhiping, Xie, Zhonglin, Xilouri, Maria, Xu, Congfeng, Xu, En, Xu, Haoxing, Xu, Jing, Xu, JinRong, Xu, Liang, Xu, Wen Wen, Xu, Xiulong, Xue, Yu, Yakhine-Diop, Sokhna MS, Yamaguchi, Masamitsu, Yamaguchi, Osamu, Yamamoto, Ai, Yamashina, Shunhei, Yan, Shengmin, Yan, Shian-Jang, Yan, Zhen, Yanagi, Yasuo, Yang, Chuanbin, Yang, Dun-Sheng, Yang, Huan, Yang, Huang-Tian, Yang, Hui, Yang, Jin-Ming, Yang, Jing, Yang, Jingyu, Yang, Ling, Yang, Liu, Yang, Ming, Yang, Pei-Ming, Yang, Qian, Yang, Seungwon, Yang, Shu, Yang, Shun-Fa, Yang, Wannian, Yang, Wei Yuan, Yang, Xiaoyong, Yang, Xuesong, Yang, Yi, Yang, Ying, Yao, Honghong, Yao, Shenggen, Yao, Xiaoqiang, Yao, Yong-Gang, Yao, Yong-Ming, Yasui, Takahiro, Yazdankhah, Meysam, Yen, Paul M, Yi, Cong, Yin, Xiao-Ming, Yin, Yanhai, Yin, Zhangyuan, Yin, Ziyi, Ying, Meidan, Ying, Zheng, Yip, Calvin K, Yiu, Stephanie Pei Tung, Yoo, Young H, Yoshida, Kiyotsugu, Yoshii, Saori R, Yoshimori, Tamotsu, Yousefi, Bahman, Yu, Boxuan, Yu, Haiyang, Yu, Jun, Yu, Li, Yu, Ming-Lung, Yu, Seong-Woon, Yu, Victor C, Yu, W Haung, Yu, Zhengping, Yu, Zhou, Yuan, Junying, Yuan, Ling-Qing, Yuan, Shilin, Yuan, Shyng-Shiou F, Yuan, Yanggang, Yuan, Zengqiang, Yue, Jianbo, Yue, Zhenyu, Yun, Jeanho, Yung, Raymond L, Zacks, David N, Zaffagnini, Gabriele, Zambelli, Vanessa O, Zanella, Isabella, Zang, Qun S, Zanivan, Sara, Zappavigna, Silvia, Zaragoza, Pilar, Zarbalis, Konstantinos S, Zarebkohan, Amir, Zarrouk, Amira, Zeitlin, Scott O, Zeng, Jialiu, Zeng, Ju-Deng, Žerovnik, Eva, Zhan, Lixuan, Zhang, Bin, Zhang, Donna D, Zhang, Hanlin, Zhang, Hong, Zhang, Honghe, Zhang, Huafeng, Zhang, Huaye, Zhang, Hui, Zhang, Hui-Ling, Zhang, Jianbin, Zhang, Jianhua, Zhang, Jing-Pu, Zhang, Kalin YB, Zhang, Leshuai W, Zhang, Lin, Zhang, Lisheng, Zhang, Lu, Zhang, Luoying, Zhang, Menghuan, Zhang, Peng, Zhang, Sheng, Zhang, Wei, Zhang, Xiangnan, Zhang, Xiao-Wei, Zhang, Xiaolei, Zhang, Xiaoyan, Zhang, Xin, Zhang, Xinxin, Zhang, Xu Dong, Zhang, Yang, Zhang, Yanjin, Zhang, Yi, Zhang, Ying-Dong, Zhang, Yingmei, Zhang, Yuan-Yuan, Zhang, Yuchen, Zhang, Zhe, Zhang, Zhengguang, Zhang, Zhibing, Zhang, Zhihai, Zhang, Zhiyong, Zhang, Zili, Zhao, Haobin, Zhao, Lei, Zhao, Shuang, Zhao, Tongbiao, Zhao, Xiao-Fan, Zhao, Ying, Zhao, Yongchao, Zhao, Yongliang, Zhao, Yuting, Zheng, Guoping, Zheng, Kai, Zheng, Ling, Zheng, Shizhong, Zheng, Xi-Long, Zheng, Yi, Zheng, Zu-Guo, Zhivotovsky, Boris, Zhong, Qing, Zhou, Ao, Zhou, Ben, Zhou, Cefan, Zhou, Gang, Zhou, Hao, Zhou, Hong, Zhou, Hongbo, Zhou, Jie, Zhou, Jing, Zhou, Jiyong, Zhou, Kailiang, Zhou, Rongjia, Zhou, Xu-Jie, Zhou, Yanshuang, Zhou, Yinghong, Zhou, Yubin, Zhou, Zheng-Yu, Zhou, Zhou, Zhu, Binglin, Zhu, Changlian, Zhu, Guo-Qing, Zhu, Haining, Zhu, Hongxin, Zhu, Hua, Zhu, Wei-Guo, Zhu, Yanping, Zhu, Yushan, Zhuang, Haixia, Zhuang, Xiaohong, Zientara-Rytter, Katarzyna, Zimmermann, Christine M, Ziviani, Elena, Zoladek, Teresa, Zong, Wei-Xing, Zorov, Dmitry B, Zorzano, Antonio, Zou, Weiping, Zou, Zhen, Zou, Zhengzhi, Zuryn, Steven, Zwerschke, Werner, Brand-Saberi, Beate, Dong, X Charlie, Kenchappa, Chandra Shekar, Li, Zuguo, Lin, Yong, Oshima, Shigeru, Rong, Yueguang, Sluimer, Judith C, Stallings, Christina L, and Tong, Chun-Kit
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phagophore ,vacuole ,Autophagosome ,neurodegeneration ,Autophagosomes ,Autophagy-Related Proteins ,flux ,macroautophagy ,stress ,LC3 ,lysosome ,Autophagy ,cancer ,Animals ,Humans ,Biological Assay ,Lysosomes ,Biomarkers - Abstract
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
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- 2021
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12. Quantification of 68Ga-FAPI-04 in systemic sclerosis-associated interstitial lung disease – Authors' reply
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Distler, Jörg HW, primary, Bergmann, Christina, additional, Kuwert, Torsten, additional, and Schmidkonz, Christian, additional
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- 2021
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13. Combined inhibition of morphogen pathways demonstrates additive antifibrotic effects and improved tolerability
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Distler, Alfiya, Lang, Veronika, Del Vecchio, Tina, Huang, Jingang, Zhang, Yun, Beyer, Christian, Lin, Neng-Yu, Palumbo-Zerr, Katrin, Distler, Oliver, Schett, Georg, and Distler, Jörg HW
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- 2014
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14. Therapeutic molecular targets of SSc-ILD
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Zhang, Yun, primary and Distler, Jörg HW, additional
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- 2020
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15. Diagnosis of pulmonary arterial hypertension in a patient with systemic sclerosis
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Distler, Jörg HW, Hoeper, Marius M, and Distler, Oliver
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- 2008
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16. Rationale for the evaluation of nintedanib as a treatment for systemic sclerosis–associated interstitial lung disease
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Wollin, Lutz, primary, Distler, Jörg HW, additional, Denton, Christopher P, additional, and Gahlemann, Martina, additional
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- 2019
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17. Cross-disease Meta-analysis of Genome-wide Association Studies for Systemic Sclerosis and Rheumatoid Arthritis Reveals IRF4 as a New Common Susceptibility Locus
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López-Isac, Elena, Martín, Jose-Ezequiel, Assassi, Shervin, Simeón, Carmen P, Carreira, Patricia, Ortego-Centeno, Norberto, Freire, Mayka, Beltrán, Emma, Narváez, Javier, Alegre-Sancho, Juan J, Fernández-Gutiérrez, Benjamín, Balsa, Alejandro, Ortiz, Ana M, González-Gay, Miguel A, Beretta, Lorenzo, Santaniello, Alessandro, Bellocchi, Chiara, Lunardi, Claudio, Moroncini, Gianluca, Gabrielli, Armando, Witte, Torsten, Hunzelmann, Nicolas, Distler, Jörg HW, Riekemasten, Gabriella, van der Helm-van Mil, Annete H, de Vries-Bouwstra, Jeska, Magro-Checa, Cesar, Voskuyl, Alexandre E, Vonk, Madelon C, Molberg, Øyvind, Merriman, Tony, Hesselstrand, Roger, Nordin, Annika, Padyukov, Leonid, Herrick, Ariane, Eyre, Steve, Koeleman, Bobby PC, Denton, Christopher P, Fonseca, Carmen, Radstake, Timothy RDJ, Worthington, Jane, Mayes, Maureen D, and Martín, Javier
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Arthritis, Rheumatoid ,Scleroderma, Systemic ,Genetic Loci ,Risk Factors ,Interferon Regulatory Factors ,Humans ,Genetic Predisposition to Disease ,Article ,Genome-Wide Association Study - Abstract
Systemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that have similar clinical and immunologic characteristics. To date, several shared SSc-RA genetic loci have been identified independently. The aim of the current study was to systematically search for new common SSc-RA loci through an interdisease meta-genome-wide association (meta-GWAS) strategy.The study was designed as a meta-analysis combining GWAS data sets of patients with SSc and patients with RA, using a strategy that allowed identification of loci with both same-direction and opposite-direction allelic effects. The top single-nucleotide polymorphisms were followed up in independent SSc and RA case-control cohorts. This allowed an increase in the sample size to a total of 8,830 patients with SSc, 16,870 patients with RA, and 43,393 healthy controls.This cross-disease meta-analysis of the GWAS data sets identified several loci with nominal association signals (P 5 × 10(-6) ) that also showed evidence of association in the disease-specific GWAS scans. These loci included several genomic regions not previously reported as shared loci, as well as several risk factors that were previously found to be associated with both diseases. Follow-up analyses of the putatively new SSc-RA loci identified IRF4 as a shared risk factor for these 2 diseases (Pcombined = 3.29 × 10(-12) ). Analysis of the biologic relevance of the known SSc-RA shared loci identified the type I interferon and interleukin-12 signaling pathways as the main common etiologic factors.This study identified a novel shared locus, IRF4, for the risk of SSc and RA, and highlighted the usefulness of a cross-disease GWAS meta-analysis strategy in the identification of common risk loci.
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- 2016
18. Epigenetic factors as drivers of fibrosis in systemic sclerosis
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Bergmann, Christina, primary and Distler, Jörg HW, additional
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- 2017
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19. Influence of TYK2 in systemic sclerosis susceptibility : a new locus in the IL-12 pathway
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López-Isac, Elena, Campillo-Davo, Diana, Bossini-Castillo, Lara, Guerra, Sandra G, Assassi, Shervin, Simeón, Carmen Pilar, Carreira, Patricia, Ortego-Centeno, Norberto, García de la Peña, Paloma, Beretta, Lorenzo, Santaniello, Alessandro, Bellocchi, Chiara, Lunardi, Claudio, Moroncini, Gianluca, Gabrielli, Armando, Riemekasten, Gabriela, Witte, Torsten, Hunzelmann, Nicolas, Kreuter, Alexander, Distler, Jörg Hw, Voskuyl, Alexandre E, de Vries-Bouwstra, Jeska, Herrick, Ariane, Worthington, Jane, Denton, Christopher P, Fonseca, Carmen, Radstake, Timothy Rdj, Mayes, Maureen D, Martín, Javier, Spanish Scleroderma Group, López-Isac, Elena, Campillo-Davo, Diana, Bossini-Castillo, Lara, Guerra, Sandra G, Assassi, Shervin, Simeón, Carmen Pilar, Carreira, Patricia, Ortego-Centeno, Norberto, García de la Peña, Paloma, Beretta, Lorenzo, Santaniello, Alessandro, Bellocchi, Chiara, Lunardi, Claudio, Moroncini, Gianluca, Gabrielli, Armando, Riemekasten, Gabriela, Witte, Torsten, Hunzelmann, Nicolas, Kreuter, Alexander, Distler, Jörg Hw, Voskuyl, Alexandre E, de Vries-Bouwstra, Jeska, Herrick, Ariane, Worthington, Jane, Denton, Christopher P, Fonseca, Carmen, Radstake, Timothy Rdj, Mayes, Maureen D, Martín, Javier, and Spanish Scleroderma Group
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- 2016
20. Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway
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Translationele immunologie, Infection & Immunity, López-Isac, Elena, Campillo-Davo, Diana, Bossini-Castillo, Lara, Guerra, Sandra G, Assassi, Shervin, Simeón, Carmen Pilar, Carreira, Patricia, Ortego-Centeno, Norberto, García de la Peña, Paloma, Beretta, Lorenzo, Santaniello, Alessandro, Bellocchi, Chiara, Lunardi, Claudio, Moroncini, Gianluca, Gabrielli, Armando, Riemekasten, Gabriela, Witte, Torsten, Hunzelmann, Nicolas, Kreuter, Alexander, Distler, Jörg Hw, Voskuyl, Alexandre E, de Vries-Bouwstra, Jeska, Herrick, Ariane, Worthington, Jane, Denton, Christopher P, Fonseca, Carmen, Radstake, Timothy Rdj, Mayes, Maureen D, Martín, Javier, Spanish Scleroderma Group, Translationele immunologie, Infection & Immunity, López-Isac, Elena, Campillo-Davo, Diana, Bossini-Castillo, Lara, Guerra, Sandra G, Assassi, Shervin, Simeón, Carmen Pilar, Carreira, Patricia, Ortego-Centeno, Norberto, García de la Peña, Paloma, Beretta, Lorenzo, Santaniello, Alessandro, Bellocchi, Chiara, Lunardi, Claudio, Moroncini, Gianluca, Gabrielli, Armando, Riemekasten, Gabriela, Witte, Torsten, Hunzelmann, Nicolas, Kreuter, Alexander, Distler, Jörg Hw, Voskuyl, Alexandre E, de Vries-Bouwstra, Jeska, Herrick, Ariane, Worthington, Jane, Denton, Christopher P, Fonseca, Carmen, Radstake, Timothy Rdj, Mayes, Maureen D, Martín, Javier, and Spanish Scleroderma Group
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- 2016
21. Guidelines for the use and interpretation of assays for monitoring autophagy:3rd edition
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Klionsky, Daniel J, Abdelmohsen, Kotb, Abe, Akihisa, Abedin, Md Joynal, Abeliovich, Hagai, Acevedo Arozena, Abraham, Adachi, Hiroaki, Adams, Christopher M, Adams, Peter D, Adeli, Khosrow, Adhihetty, Peter J, Adler, Sharon G, Agam, Galila, Agarwal, Rajesh, Aghi, Manish K, Agnello, Maria, Agostinis, Patrizia, Aguilar, Patricia V, Aguirre-Ghiso, Julio, Airoldi, Edoardo M, Ait-Si-Ali, Slimane, Akematsu, Takahiko, Akporiaye, Emmanuel T, Al-Rubeai, Mohamed, Albaiceta, Guillermo M, Albanese, Chris, Albani, Diego, Albert, Matthew L, Aldudo, Jesus, Algül, Hana, Alirezaei, Mehrdad, Alloza, Iraide, Almasan, Alexandru, Almonte-Beceril, Maylin, Alnemri, Emad S, Alonso, Covadonga, Altan-Bonnet, Nihal, Altieri, Dario C, Alvarez, Silvia, Alvarez-Erviti, Lydia, Alves, Sandro, Amadoro, Giuseppina, Amano, Atsuo, Amantini, Consuelo, Ambrosio, Santiago, Amelio, Ivano, Amer, Amal O, Amessou, Mohamed, Amon, Angelika, An, Zhenyi, Anania, Frank A, Andersen, Stig U, Andley, Usha P, Andreadi, Catherine K, 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- Published
- 2016
22. Inhibition of Notch1 promotes hedgehog signalling in a HES1-dependent manner in chondrocytes and exacerbates experimental osteoarthritis
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Lin, Neng-Yu, primary, Distler, Alfiya, additional, Beyer, Christian, additional, Philipi-Schöbinger, Ariella, additional, Breda, Silvia, additional, Dees, Clara, additional, Stock, Michael, additional, Tomcik, Michal, additional, Niemeier, Andreas, additional, Dell'Accio, Francesco, additional, Gelse, Kolja, additional, Mattson, Mark P, additional, Schett, Georg, additional, and Distler, Jörg HW, additional
- Published
- 2016
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23. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
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Klionsky, Daniel J, primary, Abdelmohsen, Kotb, additional, Abe, Akihisa, additional, Abedin, Md Joynal, additional, Abeliovich, Hagai, additional, Acevedo Arozena, Abraham, additional, Adachi, Hiroaki, additional, Adams, Christopher M, additional, Adams, Peter D, additional, Adeli, Khosrow, additional, Adhihetty, Peter J, additional, Adler, Sharon G, additional, Agam, Galila, additional, Agarwal, Rajesh, additional, Aghi, Manish K, additional, Agnello, Maria, additional, Agostinis, Patrizia, additional, Aguilar, Patricia V, additional, Aguirre-Ghiso, Julio, additional, Airoldi, Edoardo M, additional, Ait-Si-Ali, Slimane, additional, Akematsu, Takahiko, additional, Akporiaye, Emmanuel T, additional, Al-Rubeai, Mohamed, additional, Albaiceta, Guillermo M, additional, Albanese, Chris, additional, Albani, Diego, additional, Albert, Matthew L, additional, Aldudo, Jesus, additional, Algül, Hana, additional, Alirezaei, Mehrdad, additional, Alloza, Iraide, additional, Almasan, Alexandru, 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additional, Bresnick, Emery H, additional, Brest, Patrick, additional, Bridges, Dave, additional, Bringer, Marie-Agnès, additional, Brini, Marisa, additional, Brito, Glauber C, additional, Brodin, Bertha, additional, Brookes, Paul S, additional, Brown, Eric J, additional, Brown, Karen, additional, Broxmeyer, Hal E, additional, Bruhat, Alain, additional, Brum, Patricia Chakur, additional, Brumell, John H, additional, Brunetti-Pierri, Nicola, additional, Bryson-Richardson, Robert J, additional, Buch, Shilpa, additional, Buchan, Alastair M, additional, Budak, Hikmet, additional, Bulavin, Dmitry V, additional, Bultman, Scott J, additional, Bultynck, Geert, additional, Bumbasirevic, Vladimir, additional, Burelle, Yan, additional, Burke, Robert E, additional, Burmeister, Margit, additional, Bütikofer, Peter, additional, Caberlotto, Laura, additional, Cadwell, Ken, additional, Cahova, Monika, additional, Cai, Dongsheng, additional, Cai, Jingjing, additional, Cai, Qian, additional, Calatayud, Sara, additional, Camougrand, Nadine, additional, Campanella, Michelangelo, additional, Campbell, Grant R, additional, Campbell, Matthew, additional, Campello, Silvia, additional, Candau, Robin, additional, Caniggia, Isabella, additional, Cantoni, Lavinia, additional, Cao, Lizhi, additional, Caplan, Allan B, additional, Caraglia, Michele, additional, Cardinali, Claudio, additional, Cardoso, Sandra Morais, additional, Carew, Jennifer S, additional, Carleton, Laura A, additional, Carlin, Cathleen R, additional, Carloni, Silvia, additional, Carlsson, Sven R, additional, Carmona-Gutierrez, Didac, additional, Carneiro, Leticia AM, additional, Carnevali, Oliana, additional, Carra, Serena, additional, Carrier, Alice, additional, Carroll, Bernadette, additional, Casas, Caty, additional, Casas, Josefina, additional, Cassinelli, Giuliana, additional, Castets, Perrine, additional, Castro-Obregon, Susana, additional, Cavallini, Gabriella, additional, Ceccherini, Isabella, additional, Cecconi, Francesco, additional, Cederbaum, Arthur I, additional, Ceña, Valentín, additional, Cenci, Simone, additional, Cerella, Claudia, additional, Cervia, Davide, additional, Cetrullo, Silvia, additional, Chaachouay, Hassan, additional, Chae, Han-Jung, additional, Chagin, Andrei S, additional, Chai, Chee-Yin, additional, Chakrabarti, Gopal, additional, Chamilos, Georgios, additional, Chan, Edmond YW, additional, Chan, Matthew TV, additional, Chandra, Dhyan, additional, Chandra, Pallavi, additional, Chang, Chih-Peng, additional, Chang, Raymond Chuen-Chung, additional, Chang, Ta Yuan, additional, Chatham, John C, additional, Chatterjee, Saurabh, additional, Chauhan, Santosh, additional, Che, Yongsheng, additional, Cheetham, Michael E, additional, Cheluvappa, Rajkumar, additional, Chen, Chun-Jung, additional, Chen, Gang, additional, Chen, Guang-Chao, additional, Chen, Guoqiang, additional, Chen, Hongzhuan, additional, Chen, Jeff W, additional, Chen, Jian-Kang, additional, Chen, Min, additional, Chen, Mingzhou, additional, Chen, Peiwen, additional, Chen, Qi, additional, Chen, Quan, additional, Chen, Shang-Der, additional, Chen, Si, additional, Chen, Steve S-L, additional, Chen, Wei, additional, Chen, Wei-Jung, additional, Chen, Wen Qiang, additional, Chen, Wenli, additional, Chen, Xiangmei, additional, Chen, Yau-Hung, additional, Chen, Ye-Guang, additional, Chen, Yin, additional, Chen, Yingyu, additional, Chen, Yongshun, additional, Chen, Yu-Jen, additional, Chen, Yue-Qin, additional, Chen, Yujie, additional, Chen, Zhen, additional, Chen, Zhong, additional, Cheng, Alan, additional, Cheng, Christopher HK, additional, Cheng, Hua, additional, Cheong, Heesun, additional, Cherry, Sara, additional, Chesney, Jason, additional, Cheung, Chun Hei Antonio, additional, Chevet, Eric, additional, Chi, Hsiang Cheng, additional, Chi, Sung-Gil, additional, Chiacchiera, Fulvio, additional, Chiang, Hui-Ling, additional, Chiarelli, Roberto, additional, Chiariello, Mario, additional, Chieppa, Marcello, additional, Chin, Lih-Shen, additional, Chiong, Mario, additional, Chiu, Gigi NC, additional, Cho, Dong-Hyung, additional, Cho, Ssang-Goo, additional, Cho, William C, additional, Cho, Yong-Yeon, additional, Cho, Young-Seok, additional, Choi, Augustine MK, additional, Choi, Eui-Ju, additional, Choi, Eun-Kyoung, additional, Choi, Jayoung, additional, Choi, Mary E, additional, Choi, Seung-Il, additional, Chou, Tsui-Fen, additional, Chouaib, Salem, additional, Choubey, Divaker, additional, Choubey, Vinay, additional, Chow, Kuan-Chih, additional, Chowdhury, Kamal, additional, Chu, Charleen T, additional, Chuang, Tsung-Hsien, additional, Chun, Taehoon, additional, Chung, Hyewon, additional, Chung, Taijoon, additional, Chung, Yuen-Li, additional, Chwae, Yong-Joon, additional, Cianfanelli, Valentina, additional, Ciarcia, Roberto, additional, Ciechomska, Iwona A, additional, Ciriolo, Maria Rosa, additional, Cirone, Mara, additional, Claerhout, Sofie, additional, Clague, Michael J, additional, Clària, Joan, additional, Clarke, Peter GH, additional, Clarke, Robert, additional, Clementi, Emilio, additional, Cleyrat, Cédric, additional, Cnop, Miriam, additional, Coccia, Eliana M, additional, Cocco, Tiziana, additional, Codogno, Patrice, additional, Coers, Jörn, additional, Cohen, Ezra EW, additional, Colecchia, David, additional, Coletto, Luisa, additional, Coll, Núria S, additional, Colucci-Guyon, Emma, additional, Comincini, Sergio, additional, Condello, Maria, additional, Cook, Katherine L, additional, Coombs, Graham H, additional, Cooper, Cynthia D, additional, Cooper, J Mark, additional, Coppens, Isabelle, additional, Corasaniti, Maria Tiziana, additional, Corazzari, Marco, additional, Corbalan, Ramon, additional, Corcelle-Termeau, Elisabeth, additional, Cordero, Mario D, additional, Corral-Ramos, Cristina, additional, Corti, Olga, additional, Cossarizza, Andrea, additional, Costelli, Paola, additional, Costes, Safia, additional, Cotman, Susan L, additional, Coto-Montes, Ana, additional, Cottet, Sandra, additional, Couve, Eduardo, additional, Covey, Lori R, additional, Cowart, L Ashley, additional, Cox, Jeffery S, additional, Coxon, Fraser P, additional, Coyne, Carolyn B, additional, Cragg, Mark S, additional, Craven, Rolf J, additional, Crepaldi, Tiziana, additional, Crespo, Jose L, additional, Criollo, Alfredo, additional, Crippa, Valeria, additional, Cruz, Maria Teresa, additional, Cuervo, Ana Maria, additional, Cuezva, Jose M, additional, Cui, Taixing, additional, Cutillas, Pedro R, additional, Czaja, Mark J, additional, Czyzyk-Krzeska, Maria F, additional, Dagda, Ruben K, additional, Dahmen, Uta, additional, Dai, Chunsun, additional, Dai, Wenjie, additional, Dai, Yun, additional, Dalby, Kevin N, additional, Dalla Valle, Luisa, additional, Dalmasso, Guillaume, additional, D'Amelio, Marcello, additional, Damme, Markus, additional, Darfeuille-Michaud, Arlette, additional, Dargemont, Catherine, additional, Darley-Usmar, Victor M, additional, Dasarathy, Srinivasan, additional, Dasgupta, Biplab, additional, Dash, Srikanta, additional, Dass, Crispin R, additional, Davey, Hazel Marie, additional, Davids, Lester M, additional, Dávila, David, additional, Davis, Roger J, additional, Dawson, Ted M, additional, Dawson, Valina L, additional, Daza, Paula, additional, de Belleroche, Jackie, additional, de Figueiredo, Paul, additional, de Figueiredo, Regina Celia Bressan Queiroz, additional, de la Fuente, José, additional, De Martino, Luisa, additional, De Matteis, Antonella, additional, De Meyer, Guido RY, additional, De Milito, Angelo, additional, De Santi, Mauro, additional, de Souza, Wanderley, additional, De Tata, Vincenzo, additional, De Zio, Daniela, additional, Debnath, Jayanta, additional, Dechant, Reinhard, additional, Decuypere, Jean-Paul, additional, Deegan, Shane, additional, Dehay, Benjamin, additional, Del Bello, Barbara, additional, Del Re, Dominic P, additional, Delage-Mourroux, Régis, additional, Delbridge, Lea MD, additional, Deldicque, Louise, additional, Delorme-Axford, Elizabeth, additional, Deng, Yizhen, additional, Dengjel, Joern, additional, Denizot, Melanie, additional, Dent, Paul, additional, Der, Channing J, additional, Deretic, Vojo, additional, Derrien, Benoît, additional, Deutsch, Eric, additional, Devarenne, Timothy P, additional, Devenish, Rodney J, additional, Di Bartolomeo, Sabrina, additional, Di Daniele, Nicola, additional, Di Domenico, Fabio, additional, Di Nardo, Alessia, additional, Di Paola, Simone, additional, Di Pietro, Antonio, additional, Di Renzo, Livia, additional, DiAntonio, Aaron, additional, Díaz-Araya, Guillermo, additional, Díaz-Laviada, Ines, additional, Diaz-Meco, Maria T, additional, Diaz-Nido, Javier, additional, Dickey, Chad A, additional, Dickson, Robert C, additional, Diederich, Marc, additional, Digard, Paul, additional, Dikic, Ivan, additional, Dinesh-Kumar, Savithrama P, additional, Ding, Chan, additional, Ding, Wen-Xing, additional, Ding, Zufeng, additional, Dini, Luciana, additional, Distler, Jörg HW, additional, Diwan, Abhinav, additional, Djavaheri-Mergny, Mojgan, additional, Dmytruk, Kostyantyn, additional, Dobson, Renwick CJ, additional, Doetsch, Volker, additional, Dokladny, Karol, additional, Dokudovskaya, Svetlana, additional, Donadelli, Massimo, additional, Dong, X Charlie, additional, Dong, Xiaonan, additional, Dong, Zheng, additional, Donohue, Terrence M, additional, Doran, Kelly S, additional, D'Orazi, Gabriella, additional, Dorn, Gerald W, additional, Dosenko, Victor, additional, Dridi, Sami, additional, Drucker, Liat, additional, Du, Jie, additional, Du, Li-Lin, additional, Du, Lihuan, additional, du Toit, André, additional, Dua, Priyamvada, additional, Duan, Lei, additional, Duann, Pu, additional, Dubey, Vikash Kumar, additional, Duchen, Michael R, additional, Duchosal, Michel A, additional, Duez, Helene, additional, Dugail, Isabelle, additional, Dumit, Verónica I, additional, Duncan, Mara C, additional, Dunlop, Elaine A, additional, Dunn, William A, additional, Dupont, Nicolas, additional, Dupuis, Luc, additional, Durán, Raúl V, additional, Durcan, Thomas M, additional, Duvezin-Caubet, Stéphane, additional, Duvvuri, Umamaheswar, additional, Eapen, Vinay, additional, Ebrahimi-Fakhari, Darius, additional, Echard, Arnaud, additional, Eckhart, Leopold, additional, Edelstein, Charles L, additional, Edinger, Aimee L, additional, Eichinger, Ludwig, additional, Eisenberg, Tobias, additional, Eisenberg-Lerner, Avital, additional, Eissa, N Tony, additional, El-Deiry, Wafik S, additional, El-Khoury, Victoria, additional, Elazar, Zvulun, additional, Eldar-Finkelman, Hagit, additional, Elliott, Chris JH, additional, Emanuele, Enzo, additional, Emmenegger, Urban, additional, Engedal, Nikolai, additional, Engelbrecht, Anna-Mart, additional, Engelender, Simone, additional, Enserink, Jorrit M, additional, Erdmann, Ralf, additional, Erenpreisa, Jekaterina, additional, Eri, Rajaraman, additional, Eriksen, Jason L, additional, Erman, Andreja, additional, Escalante, Ricardo, additional, Eskelinen, Eeva-Liisa, additional, Espert, Lucile, additional, Esteban-Martínez, Lorena, additional, Evans, Thomas J, additional, Fabri, Mario, additional, Fabrias, Gemma, additional, Fabrizi, Cinzia, additional, Facchiano, Antonio, additional, Færgeman, Nils J, additional, Faggioni, Alberto, additional, Fairlie, W Douglas, additional, Fan, Chunhai, additional, Fan, Daping, additional, Fan, Jie, additional, Fang, Shengyun, additional, Fanto, Manolis, additional, Fanzani, Alessandro, additional, Farkas, Thomas, additional, Faure, Mathias, additional, Favier, Francois B, additional, Fearnhead, Howard, additional, Federici, Massimo, additional, Fei, Erkang, additional, Felizardo, Tania C, additional, Feng, Hua, additional, Feng, Yibin, additional, Feng, Yuchen, additional, Ferguson, Thomas A, additional, Fernández, Álvaro F, additional, Fernandez-Barrena, Maite G, additional, Fernandez-Checa, Jose C, additional, Fernández-López, Arsenio, additional, Fernandez-Zapico, Martin E, additional, Feron, Olivier, additional, Ferraro, Elisabetta, additional, Ferreira-Halder, Carmen Veríssima, additional, Fesus, Laszlo, additional, Feuer, Ralph, additional, Fiesel, Fabienne C, additional, Filippi-Chiela, Eduardo C, additional, Filomeni, Giuseppe, additional, Fimia, Gian Maria, additional, Fingert, John H, additional, Finkbeiner, Steven, additional, Finkel, Toren, additional, Fiorito, Filomena, additional, Fisher, Paul B, additional, Flajolet, Marc, additional, Flamigni, Flavio, additional, Florey, Oliver, additional, Florio, Salvatore, additional, Floto, R Andres, additional, Folini, Marco, additional, Follo, Carlo, additional, Fon, Edward A, additional, Fornai, Francesco, additional, Fortunato, Franco, additional, Fraldi, Alessandro, additional, Franco, Rodrigo, additional, Francois, Arnaud, additional, François, Aurélie, additional, Frankel, Lisa B, additional, Fraser, Iain DC, additional, Frey, Norbert, additional, Freyssenet, Damien G, additional, Frezza, Christian, additional, Friedman, Scott L, additional, Frigo, Daniel E, additional, Fu, Dongxu, additional, Fuentes, José M, additional, Fueyo, Juan, additional, Fujitani, Yoshio, additional, Fujiwara, Yuuki, additional, Fujiya, Mikihiro, additional, Fukuda, Mitsunori, additional, Fulda, Simone, additional, Fusco, Carmela, additional, Gabryel, Bozena, additional, Gaestel, Matthias, additional, Gailly, Philippe, additional, Gajewska, Malgorzata, additional, Galadari, Sehamuddin, additional, Galili, Gad, additional, Galindo, Inmaculada, additional, Galindo, Maria F, additional, Galliciotti, Giovanna, additional, Galluzzi, Lorenzo, additional, Galluzzi, Luca, additional, Galy, Vincent, additional, Gammoh, Noor, additional, Gandy, Sam, additional, Ganesan, Anand K, additional, Ganesan, Swamynathan, additional, Ganley, Ian G, additional, Gannagé, Monique, additional, Gao, Fen-Biao, additional, Gao, Feng, additional, Gao, Jian-Xin, additional, García Nannig, Lorena, additional, García Véscovi, Eleonora, additional, Garcia-Macía, Marina, additional, Garcia-Ruiz, Carmen, additional, Garg, Abhishek D, additional, Garg, Pramod Kumar, additional, Gargini, Ricardo, additional, Gassen, Nils Christian, additional, Gatica, Damián, additional, Gatti, Evelina, additional, Gavard, Julie, additional, Gavathiotis, Evripidis, additional, Ge, Liang, additional, Ge, Pengfei, additional, Ge, Shengfang, additional, Gean, Po-Wu, additional, Gelmetti, Vania, additional, Genazzani, Armando A, additional, Geng, Jiefei, additional, Genschik, Pascal, additional, Gerner, Lisa, additional, Gestwicki, Jason E, additional, Gewirtz, David A, additional, Ghavami, Saeid, additional, Ghigo, Eric, additional, Ghosh, Debabrata, additional, Giammarioli, Anna Maria, additional, Giampieri, Francesca, additional, Giampietri, Claudia, additional, Giatromanolaki, Alexandra, additional, Gibbings, Derrick J, additional, Gibellini, Lara, additional, Gibson, Spencer B, additional, Ginet, Vanessa, additional, Giordano, Antonio, additional, Giorgini, Flaviano, additional, Giovannetti, Elisa, additional, Girardin, Stephen E, additional, Gispert, Suzana, additional, Giuliano, Sandy, additional, Gladson, Candece L, additional, Glavic, Alvaro, additional, Gleave, Martin, additional, Godefroy, Nelly, additional, Gogal, Robert M, additional, Gokulan, Kuppan, additional, Goldman, Gustavo H, additional, Goletti, Delia, additional, Goligorsky, Michael S, additional, Gomes, Aldrin V, additional, Gomes, Ligia C, additional, Gomez, Hernando, additional, Gomez-Manzano, Candelaria, additional, Gómez-Sánchez, Rubén, additional, Gonçalves, Dawit AP, additional, Goncu, Ebru, additional, Gong, Qingqiu, additional, Gongora, Céline, additional, Gonzalez, Carlos B, additional, Gonzalez-Alegre, Pedro, additional, Gonzalez-Cabo, Pilar, additional, González-Polo, Rosa Ana, additional, Goping, Ing Swie, additional, Gorbea, Carlos, additional, Gorbunov, Nikolai V, additional, Goring, Daphne R, additional, Gorman, Adrienne M, additional, Gorski, Sharon M, additional, Goruppi, Sandro, additional, Goto-Yamada, Shino, additional, Gotor, Cecilia, additional, Gottlieb, Roberta A, additional, Gozes, Illana, additional, Gozuacik, Devrim, additional, Graba, Yacine, additional, Graef, Martin, additional, Granato, Giovanna E, additional, Grant, Gary Dean, additional, Grant, Steven, additional, Gravina, Giovanni Luca, additional, Green, Douglas R, additional, Greenhough, Alexander, additional, Greenwood, Michael T, additional, Grimaldi, Benedetto, additional, Gros, Frédéric, additional, Grose, Charles, additional, Groulx, Jean-Francois, additional, Gruber, Florian, additional, Grumati, Paolo, additional, Grune, Tilman, additional, Guan, Jun-Lin, additional, Guan, Kun-Liang, additional, Guerra, Barbara, additional, Guillen, Carlos, additional, Gulshan, Kailash, additional, Gunst, Jan, additional, Guo, Chuanyong, additional, Guo, Lei, additional, Guo, Ming, additional, Guo, Wenjie, additional, Guo, Xu-Guang, additional, Gust, Andrea A, additional, Gustafsson, Åsa B, additional, Gutierrez, Elaine, additional, Gutierrez, Maximiliano G, additional, Gwak, Ho-Shin, additional, Haas, Albert, additional, Haber, James E, additional, Hadano, Shinji, additional, Hagedorn, Monica, additional, Hahn, David R, additional, Halayko, Andrew J, additional, Hamacher-Brady, Anne, additional, Hamada, Kozo, additional, Hamai, Ahmed, additional, Hamann, Andrea, additional, Hamasaki, Maho, additional, Hamer, Isabelle, additional, Hamid, Qutayba, additional, Hammond, Ester M, additional, Han, Feng, additional, Han, Weidong, additional, Handa, James T, additional, Hanover, John A, additional, Hansen, Malene, additional, Harada, Masaru, additional, Harhaji-Trajkovic, Ljubica, additional, Harper, J Wade, additional, Harrath, Abdel Halim, additional, Harris, Adrian L, additional, Harris, James, additional, Hasler, Udo, additional, Hasselblatt, Peter, additional, Hasui, Kazuhisa, additional, Hawley, Robert G, additional, Hawley, Teresa S, additional, He, Congcong, additional, He, Cynthia Y, additional, He, Fengtian, additional, He, Gu, additional, He, Rong-Rong, additional, He, Xian-Hui, additional, He, You-Wen, additional, He, Yu-Ying, additional, Heath, Joan K, additional, Hébert, Marie-Josée, additional, Heinzen, Robert A, additional, Helgason, Gudmundur Vignir, additional, Hensel, Michael, additional, Henske, Elizabeth P, additional, Her, Chengtao, additional, Herman, Paul K, additional, Hernández, Agustín, additional, Hernandez, Carlos, additional, Hernández-Tiedra, Sonia, additional, Hetz, Claudio, additional, Hiesinger, P Robin, additional, Higaki, Katsumi, additional, Hilfiker, Sabine, additional, Hill, Bradford G, additional, Hill, Joseph A, additional, Hill, William D, additional, Hino, Keisuke, additional, Hofius, Daniel, additional, Hofman, Paul, additional, Höglinger, Günter U, additional, Höhfeld, Jörg, additional, Holz, Marina K, additional, Hong, Yonggeun, additional, Hood, David A, additional, Hoozemans, Jeroen JM, additional, Hoppe, Thorsten, additional, Hsu, Chin, additional, Hsu, Chin-Yuan, additional, Hsu, Li-Chung, additional, Hu, Dong, additional, Hu, Guochang, additional, Hu, Hong-Ming, additional, Hu, Hongbo, additional, Hu, Ming Chang, additional, Hu, Yu-Chen, additional, Hu, Zhuo-Wei, additional, Hua, Fang, additional, Hua, Ya, additional, Huang, Canhua, additional, Huang, Huey-Lan, additional, Huang, Kuo-How, additional, Huang, Kuo-Yang, additional, Huang, Shile, additional, Huang, Shiqian, additional, Huang, Wei-Pang, additional, Huang, Yi-Ran, additional, Huang, Yong, additional, Huang, Yunfei, additional, Huber, Tobias B, additional, Huebbe, Patricia, additional, Huh, Won-Ki, additional, Hulmi, Juha J, additional, Hur, Gang Min, additional, Hurley, James H, additional, Husak, Zvenyslava, additional, Hussain, Sabah NA, additional, Hussain, Salik, additional, Hwang, Jung Jin, additional, Hwang, Seungmin, additional, Hwang, Thomas IS, additional, Ichihara, Atsuhiro, additional, Imai, Yuzuru, additional, Imbriano, Carol, additional, Inomata, Megumi, additional, Into, Takeshi, additional, Iovane, Valentina, additional, Iovanna, Juan L, additional, Iozzo, Renato V, additional, Ip, Nancy Y, additional, Irazoqui, Javier E, additional, Iribarren, Pablo, additional, Isaka, Yoshitaka, additional, Isakovic, Aleksandra J, additional, Ischiropoulos, Harry, additional, Isenberg, Jeffrey S, additional, Ishaq, Mohammad, additional, Ishida, Hiroyuki, additional, Ishii, Isao, additional, Ishmael, Jane E, additional, Isidoro, Ciro, additional, Isobe, Ken-ichi, additional, Isono, Erika, additional, Issazadeh-Navikas, Shohreh, additional, Itahana, Koji, additional, Itakura, Eisuke, additional, Ivanov, Andrei I, additional, Iyer, Anand Krishnan V, additional, Izquierdo, José M, additional, Izumi, Yotaro, additional, Izzo, Valentina, additional, Jäättelä, Marja, additional, Jaber, Nadia, additional, Jackson, Daniel John, additional, Jackson, William T, additional, Jacob, Tony George, additional, Jacques, Thomas S, additional, Jagannath, Chinnaswamy, additional, Jain, Ashish, additional, Jana, Nihar Ranjan, additional, Jang, Byoung Kuk, additional, Jani, Alkesh, additional, Janji, Bassam, additional, Jannig, Paulo Roberto, additional, Jansson, Patric J, additional, Jean, Steve, additional, Jendrach, Marina, additional, Jeon, Ju-Hong, additional, Jessen, Niels, additional, Jeung, Eui-Bae, additional, Jia, Kailiang, additional, Jia, Lijun, additional, Jiang, Hong, additional, Jiang, Hongchi, additional, Jiang, Liwen, additional, Jiang, Teng, additional, Jiang, Xiaoyan, additional, Jiang, Xuejun, additional, Jiang, Ying, additional, Jiang, Yongjun, additional, Jiménez, Alberto, additional, Jin, Cheng, additional, Jin, Hongchuan, additional, Jin, Lei, additional, Jin, Meiyan, additional, Jin, Shengkan, additional, Jinwal, Umesh Kumar, additional, Jo, Eun-Kyeong, additional, Johansen, Terje, additional, Johnson, Daniel E, additional, Johnson, Gail VW, additional, Johnson, James D, additional, Jonasch, Eric, additional, Jones, Chris, additional, Joosten, Leo AB, additional, Jordan, Joaquin, additional, Joseph, Anna-Maria, additional, Joseph, Bertrand, additional, Joubert, Annie M, additional, Ju, Dianwen, additional, Ju, Jingfang, additional, Juan, Hsueh-Fen, additional, Juenemann, Katrin, additional, Juhász, Gábor, additional, Jung, Hye Seung, additional, Jung, Jae U, additional, Jung, Yong-Keun, additional, Jungbluth, Heinz, additional, Justice, Matthew J, additional, Jutten, Barry, additional, Kaakoush, Nadeem O, additional, Kaarniranta, Kai, additional, Kaasik, Allen, additional, Kabuta, Tomohiro, additional, Kaeffer, Bertrand, additional, Kågedal, Katarina, additional, Kahana, Alon, additional, Kajimura, Shingo, additional, Kakhlon, Or, additional, Kalia, Manjula, additional, Kalvakolanu, Dhan V, additional, Kamada, Yoshiaki, additional, Kambas, Konstantinos, additional, Kaminskyy, Vitaliy O, additional, Kampinga, Harm H, additional, Kandouz, Mustapha, additional, Kang, Chanhee, additional, Kang, Rui, additional, Kang, Tae-Cheon, additional, Kanki, Tomotake, additional, Kanneganti, Thirumala-Devi, additional, Kanno, Haruo, additional, Kanthasamy, Anumantha G, additional, Kantorow, Marc, additional, Kaparakis-Liaskos, Maria, additional, Kapuy, Orsolya, additional, Karantza, Vassiliki, additional, Karim, Md Razaul, additional, Karmakar, Parimal, additional, Kaser, Arthur, additional, Kaushik, Susmita, additional, Kawula, Thomas, additional, Kaynar, A Murat, additional, Ke, Po-Yuan, additional, Ke, Zun-Ji, additional, Kehrl, John H, additional, Keller, Kate E, additional, Kemper, Jongsook Kim, additional, Kenworthy, Anne K, additional, Kepp, Oliver, additional, Kern, Andreas, additional, Kesari, Santosh, additional, Kessel, David, additional, Ketteler, Robin, additional, Kettelhut, Isis do Carmo, additional, Khambu, Bilon, additional, Khan, Muzamil Majid, additional, Khandelwal, Vinoth KM, additional, Khare, Sangeeta, additional, Kiang, Juliann G, additional, Kiger, Amy A, additional, Kihara, Akio, additional, Kim, Arianna L, additional, Kim, Cheol Hyeon, additional, Kim, Deok Ryong, additional, Kim, Do-Hyung, additional, Kim, Eung Kweon, additional, Kim, Hye Young, additional, Kim, Hyung-Ryong, additional, Kim, Jae-Sung, additional, Kim, Jeong Hun, additional, Kim, Jin Cheon, additional, Kim, Jin Hyoung, additional, Kim, Kwang Woon, additional, Kim, Michael D, additional, Kim, Moon-Moo, additional, Kim, Peter K, additional, Kim, Seong Who, additional, Kim, Soo-Youl, additional, Kim, Yong-Sun, additional, Kim, Yonghyun, additional, Kimchi, Adi, additional, Kimmelman, Alec C, additional, Kimura, Tomonori, additional, King, Jason S, additional, Kirkegaard, Karla, additional, Kirkin, Vladimir, additional, Kirshenbaum, Lorrie A, additional, Kishi, Shuji, additional, Kitajima, Yasuo, additional, Kitamoto, Katsuhiko, additional, Kitaoka, Yasushi, additional, Kitazato, Kaio, additional, Kley, Rudolf A, additional, Klimecki, Walter T, additional, Klinkenberg, Michael, additional, Klucken, Jochen, additional, Knævelsrud, Helene, additional, Knecht, Erwin, additional, Knuppertz, Laura, additional, Ko, Jiunn-Liang, additional, Kobayashi, Satoru, additional, Koch, Jan C, additional, Koechlin-Ramonatxo, Christelle, additional, Koenig, Ulrich, additional, Koh, Young Ho, additional, Köhler, Katja, additional, Kohlwein, Sepp D, additional, Koike, Masato, additional, Komatsu, Masaaki, additional, Kominami, Eiki, additional, Kong, Dexin, additional, Kong, Hee Jeong, additional, Konstantakou, Eumorphia G, additional, Kopp, Benjamin T, additional, Korcsmaros, Tamas, additional, Korhonen, Laura, additional, Korolchuk, Viktor I, additional, Koshkina, Nadya V, additional, Kou, Yanjun, additional, Koukourakis, Michael I, additional, Koumenis, Constantinos, additional, Kovács, Attila L, additional, Kovács, Tibor, additional, Kovacs, Werner J, additional, Koya, Daisuke, additional, Kraft, Claudine, additional, Krainc, Dimitri, additional, Kramer, Helmut, additional, Kravic-Stevovic, Tamara, additional, Krek, Wilhelm, additional, Kretz-Remy, Carole, additional, Krick, Roswitha, additional, Krishnamurthy, Malathi, additional, Kriston-Vizi, Janos, additional, Kroemer, Guido, additional, Kruer, Michael C, additional, Kruger, Rejko, additional, Ktistakis, Nicholas T, additional, Kuchitsu, Kazuyuki, additional, Kuhn, Christian, additional, Kumar, Addanki Pratap, additional, Kumar, Anuj, additional, Kumar, Ashok, additional, Kumar, Deepak, additional, Kumar, Dhiraj, additional, Kumar, Rakesh, additional, Kumar, Sharad, additional, Kundu, Mondira, additional, Kung, Hsing-Jien, additional, Kuno, Atsushi, additional, Kuo, Sheng-Han, additional, Kuret, Jeff, additional, Kurz, Tino, additional, Kwok, Terry, additional, Kwon, Taeg Kyu, additional, Kwon, Yong Tae, additional, Kyrmizi, Irene, additional, La Spada, Albert R, additional, Lafont, Frank, additional, Lahm, Tim, additional, Lakkaraju, Aparna, additional, Lam, Truong, additional, Lamark, Trond, additional, Lancel, Steve, additional, Landowski, Terry H, additional, Lane, Darius JR, additional, Lane, Jon D, additional, Lanzi, Cinzia, additional, Lapaquette, Pierre, additional, Lapierre, Louis R, additional, Laporte, Jocelyn, additional, Laukkarinen, Johanna, additional, Laurie, Gordon W, additional, Lavandero, Sergio, additional, Lavie, Lena, additional, LaVoie, Matthew J, additional, Law, Betty Yuen Kwan, additional, Law, Helen Ka-wai, additional, Law, Kelsey B, additional, Layfield, Robert, additional, Lazo, Pedro A, additional, Le Cam, Laurent, additional, Le Roch, Karine G, additional, Le Stunff, Hervé, additional, Leardkamolkarn, Vijittra, additional, Lecuit, Marc, additional, Lee, Byung-Hoon, additional, Lee, Che-Hsin, additional, Lee, Erinna F, additional, Lee, Gyun Min, additional, Lee, He-Jin, additional, Lee, Hsinyu, additional, Lee, Jae Keun, additional, Lee, Jongdae, additional, Lee, Ju-hyun, additional, Lee, Jun Hee, additional, Lee, Michael, additional, Lee, Myung-Shik, additional, Lee, Patty J, additional, Lee, Sam W, additional, Lee, Seung-Jae, additional, Lee, Shiow-Ju, additional, Lee, Stella Y, additional, Lee, Sug Hyung, additional, Lee, Sung Sik, additional, Lee, Sung-Joon, additional, Lee, Sunhee, additional, Lee, Ying-Ray, additional, Lee, Yong J, additional, Lee, Young H, additional, Leeuwenburgh, Christiaan, additional, Lefort, Sylvain, additional, Legouis, Renaud, additional, Lei, Jinzhi, additional, Lei, Qun-Ying, additional, Leib, David A, additional, Leibowitz, Gil, additional, Lekli, Istvan, additional, Lemaire, Stéphane D, additional, Lemasters, John J, additional, Lemberg, Marius K, additional, Lemoine, Antoinette, additional, Leng, Shuilong, additional, Lenz, Guido, additional, Lenzi, Paola, additional, Lerman, Lilach O, additional, Lettieri Barbato, Daniele, additional, Leu, Julia I-Ju, additional, Leung, Hing Y, additional, Levine, Beth, additional, Lewis, Patrick A, additional, Lezoualc'h, Frank, additional, Li, Chi, additional, Li, Faqiang, additional, Li, Feng-Jun, additional, Li, Jun, additional, Li, Ke, additional, Li, Lian, additional, Li, Min, additional, Li, Qiang, additional, Li, Rui, additional, Li, Sheng, additional, Li, Wei, additional, Li, Xiaotao, additional, Li, Yumin, additional, Lian, Jiqin, additional, Liang, Chengyu, additional, Liang, Qiangrong, additional, Liao, Yulin, additional, Liberal, Joana, additional, Liberski, Pawel P, additional, Lie, Pearl, additional, Lieberman, Andrew P, additional, Lim, Hyunjung Jade, additional, Lim, Kah-Leong, additional, Lim, Kyu, additional, Lima, Raquel T, additional, Lin, Chang-Shen, additional, Lin, Chiou-Feng, additional, Lin, Fang, additional, Lin, Fangming, additional, Lin, Fu-Cheng, additional, Lin, Kui, additional, Lin, Kwang-Huei, additional, Lin, Pei-Hui, additional, Lin, Tianwei, additional, Lin, Wan-Wan, additional, Lin, Yee-Shin, additional, Lin, Yong, additional, Linden, Rafael, additional, Lindholm, Dan, additional, Lindqvist, Lisa M, additional, Lingor, Paul, additional, Linkermann, Andreas, additional, Liotta, Lance A, additional, Lipinski, Marta M, additional, Lira, Vitor A, additional, Lisanti, Michael P, additional, Liton, Paloma B, additional, Liu, Bo, additional, Liu, Chong, additional, Liu, Chun-Feng, additional, Liu, Fei, additional, Liu, Hung-Jen, additional, Liu, Jianxun, additional, Liu, Jing-Jing, additional, Liu, Jing-Lan, additional, Liu, Ke, additional, Liu, Leyuan, additional, Liu, Liang, additional, Liu, Quentin, additional, Liu, Rong-Yu, additional, Liu, Shiming, additional, Liu, Shuwen, additional, Liu, Wei, additional, Liu, Xian-De, additional, Liu, Xiangguo, additional, Liu, Xiao-Hong, additional, Liu, Xinfeng, additional, Liu, Xu, additional, Liu, Xueqin, additional, Liu, Yang, additional, Liu, Yule, additional, Liu, Zexian, additional, Liu, Zhe, additional, Liuzzi, Juan P, additional, Lizard, Gérard, additional, Ljujic, Mila, additional, Lodhi, Irfan J, additional, Logue, Susan E, additional, Lokeshwar, Bal L, additional, Long, Yun Chau, additional, Lonial, Sagar, additional, Loos, Benjamin, additional, López-Otín, Carlos, additional, López-Vicario, Cristina, additional, Lorente, Mar, additional, Lorenzi, Philip L, additional, Lõrincz, Péter, additional, Los, Marek, additional, Lotze, Michael T, additional, Lovat, Penny E, additional, Lu, Binfeng, additional, Lu, Bo, additional, Lu, Jiahong, additional, Lu, Qing, additional, Lu, She-Min, additional, Lu, Shuyan, additional, Lu, Yingying, additional, Luciano, Frédéric, additional, Luckhart, Shirley, additional, Lucocq, John Milton, additional, Ludovico, Paula, additional, Lugea, Aurelia, additional, Lukacs, Nicholas W, additional, Lum, Julian J, additional, Lund, Anders H, additional, Luo, Honglin, additional, Luo, Jia, additional, Luo, Shouqing, additional, Luparello, Claudio, additional, Lyons, Timothy, additional, Ma, Jianjie, additional, Ma, Yi, additional, Ma, Yong, additional, Ma, Zhenyi, additional, Machado, Juliano, additional, Machado-Santelli, Glaucia M, additional, Macian, Fernando, additional, MacIntosh, Gustavo C, additional, MacKeigan, Jeffrey P, additional, Macleod, Kay F, additional, MacMicking, John D, additional, MacMillan-Crow, Lee Ann, additional, Madeo, Frank, additional, Madesh, Muniswamy, additional, Madrigal-Matute, Julio, additional, Maeda, Akiko, additional, Maeda, Tatsuya, additional, Maegawa, Gustavo, additional, Maellaro, Emilia, additional, Maes, Hannelore, additional, Magariños, Marta, additional, Maiese, Kenneth, additional, Maiti, Tapas K, additional, Maiuri, Luigi, additional, Maiuri, Maria Chiara, additional, Maki, Carl G, additional, Malli, Roland, additional, Malorni, Walter, additional, Maloyan, Alina, additional, Mami-Chouaib, Fathia, additional, Man, Na, additional, Mancias, Joseph D, additional, Mandelkow, Eva-Maria, additional, Mandell, Michael A, additional, Manfredi, Angelo A, additional, Manié, Serge N, additional, Manzoni, Claudia, additional, Mao, Kai, additional, Mao, Zixu, additional, Mao, Zong-Wan, additional, Marambaud, Philippe, additional, Marconi, Anna Maria, additional, Marelja, Zvonimir, additional, Marfe, Gabriella, additional, Margeta, Marta, additional, Margittai, Eva, additional, Mari, Muriel, additional, Mariani, Francesca V, additional, Marin, Concepcio, additional, Marinelli, Sara, additional, Mariño, Guillermo, additional, Markovic, Ivanka, additional, Marquez, Rebecca, additional, Martelli, Alberto M, additional, Martens, Sascha, additional, Martin, Katie R, additional, Martin, Seamus J, additional, Martin, Shaun, additional, Martin-Acebes, Miguel A, additional, Martín-Sanz, Paloma, additional, Martinand-Mari, Camille, additional, Martinet, Wim, additional, Martinez, Jennifer, additional, Martinez-Lopez, Nuria, additional, Martinez-Outschoorn, Ubaldo, additional, Martínez-Velázquez, Moisés, additional, Martinez-Vicente, Marta, additional, Martins, Waleska Kerllen, additional, Mashima, Hirosato, additional, Mastrianni, James A, additional, Matarese, Giuseppe, additional, Matarrese, Paola, additional, Mateo, Roberto, additional, Matoba, Satoaki, additional, Matsumoto, Naomichi, additional, Matsushita, Takehiko, additional, Matsuura, Akira, additional, Matsuzawa, Takeshi, additional, Mattson, Mark P, additional, Matus, Soledad, additional, Maugeri, Norma, additional, Mauvezin, Caroline, additional, Mayer, Andreas, additional, Maysinger, Dusica, additional, Mazzolini, Guillermo D, additional, McBrayer, Mary Kate, additional, McCall, Kimberly, additional, McCormick, Craig, additional, McInerney, Gerald M, additional, McIver, Skye C, additional, McKenna, Sharon, additional, McMahon, John J, additional, McNeish, Iain A, additional, Mechta-Grigoriou, Fatima, additional, Medema, Jan Paul, additional, Medina, Diego L, additional, Megyeri, Klara, additional, Mehrpour, Maryam, additional, Mehta, Jawahar L, additional, Mei, Yide, additional, Meier, Ute-Christiane, additional, Meijer, Alfred J, additional, Meléndez, Alicia, additional, Melino, Gerry, additional, Melino, Sonia, additional, de Melo, Edesio Jose Tenorio, additional, Mena, Maria A, additional, Meneghini, Marc D, additional, Menendez, Javier A, additional, Menezes, Regina, additional, Meng, Liesu, additional, Meng, Ling-hua, additional, Meng, Songshu, additional, Menghini, Rossella, additional, Menko, A Sue, additional, Menna-Barreto, Rubem FS, additional, Menon, Manoj B, additional, Meraz-Ríos, Marco A, additional, Merla, Giuseppe, additional, Merlini, Luciano, additional, Merlot, Angelica M, additional, Meryk, Andreas, additional, Meschini, Stefania, additional, Meyer, Joel N, additional, Mi, Man-tian, additional, Miao, Chao-Yu, additional, Micale, Lucia, additional, Michaeli, Simon, additional, Michiels, Carine, additional, Migliaccio, Anna Rita, additional, Mihailidou, Anastasia Susie, additional, Mijaljica, Dalibor, additional, Mikoshiba, Katsuhiko, additional, Milan, Enrico, additional, Miller-Fleming, Leonor, additional, Mills, Gordon B, additional, Mills, Ian G, additional, Minakaki, Georgia, additional, Minassian, Berge A, additional, Ming, Xiu-Fen, additional, Minibayeva, Farida, additional, Minina, Elena A, additional, Mintern, Justine D, additional, Minucci, Saverio, additional, Miranda-Vizuete, Antonio, additional, Mitchell, Claire H, additional, Miyamoto, Shigeki, additional, Miyazawa, Keisuke, additional, Mizushima, Noboru, additional, Mnich, Katarzyna, additional, Mograbi, Baharia, additional, Mohseni, Simin, additional, Moita, Luis Ferreira, additional, Molinari, Marco, additional, Molinari, Maurizio, additional, Møller, Andreas Buch, additional, Mollereau, Bertrand, additional, Mollinedo, Faustino, additional, Mongillo, Marco, additional, Monick, Martha M, additional, Montagnaro, Serena, additional, Montell, Craig, additional, Moore, Darren J, additional, Moore, Michael N, additional, Mora-Rodriguez, Rodrigo, additional, Moreira, Paula I, additional, Morel, Etienne, additional, Morelli, Maria Beatrice, additional, Moreno, Sandra, additional, Morgan, Michael J, additional, Moris, Arnaud, additional, Moriyasu, Yuji, additional, Morrison, Janna L, additional, Morrison, Lynda A, additional, Morselli, Eugenia, additional, Moscat, Jorge, additional, Moseley, Pope L, additional, Mostowy, Serge, additional, Motori, Elisa, additional, Mottet, Denis, additional, Mottram, Jeremy C, additional, Moussa, Charbel E-H, additional, Mpakou, Vassiliki E, additional, Mukhtar, Hasan, additional, Mulcahy Levy, Jean M, additional, Muller, Sylviane, additional, Muñoz-Moreno, Raquel, additional, Muñoz-Pinedo, Cristina, additional, Münz, Christian, additional, Murphy, Maureen E, additional, Murray, James T, additional, Murthy, Aditya, additional, Mysorekar, Indira U, additional, Nabi, Ivan R, additional, Nabissi, Massimo, additional, Nader, Gustavo A, additional, Nagahara, Yukitoshi, additional, Nagai, Yoshitaka, additional, Nagata, Kazuhiro, additional, Nagelkerke, Anika, additional, Nagy, Péter, additional, Naidu, Samisubbu R, additional, Nair, Sreejayan, additional, Nakano, Hiroyasu, additional, Nakatogawa, Hitoshi, additional, Nanjundan, Meera, additional, Napolitano, Gennaro, additional, Naqvi, Naweed I, additional, Nardacci, Roberta, additional, Narendra, Derek P, additional, Narita, Masashi, additional, Nascimbeni, Anna Chiara, additional, Natarajan, Ramesh, additional, Navegantes, Luiz C, additional, Nawrocki, Steffan T, additional, Nazarko, Taras Y, additional, Nazarko, Volodymyr Y, additional, Neill, Thomas, additional, Neri, Luca M, additional, Netea, Mihai G, additional, Netea-Maier, Romana T, additional, Neves, Bruno M, additional, Ney, Paul A, additional, Nezis, Ioannis P, additional, Nguyen, Hang TT, additional, Nguyen, Huu Phuc, additional, Nicot, Anne-Sophie, additional, Nilsen, Hilde, additional, Nilsson, Per, additional, Nishimura, Mikio, additional, Nishino, Ichizo, additional, Niso-Santano, Mireia, additional, Niu, Hua, additional, Nixon, Ralph A, additional, Njar, Vincent CO, additional, Noda, Takeshi, additional, Noegel, Angelika A, additional, Nolte, Elsie Magdalena, additional, Norberg, Erik, additional, Norga, Koenraad K, additional, Noureini, Sakineh Kazemi, additional, Notomi, Shoji, additional, Notterpek, Lucia, additional, Nowikovsky, Karin, additional, Nukina, Nobuyuki, additional, Nürnberger, Thorsten, additional, O'Donnell, Valerie B, additional, O'Donovan, Tracey, additional, O'Dwyer, Peter J, additional, Oehme, Ina, additional, Oeste, Clara L, additional, Ogawa, Michinaga, additional, Ogretmen, Besim, additional, Ogura, Yuji, additional, Oh, Young J, additional, Ohmuraya, Masaki, additional, Ohshima, Takayuki, additional, Ojha, Rani, additional, Okamoto, Koji, additional, Okazaki, Toshiro, additional, Oliver, F Javier, additional, Ollinger, Karin, additional, Olsson, Stefan, additional, Orban, Daniel P, additional, Ordonez, Paulina, additional, Orhon, Idil, additional, Orosz, Laszlo, additional, O'Rourke, Eyleen J, additional, Orozco, Helena, additional, Ortega, Angel L, additional, Ortona, Elena, additional, Osellame, Laura D, additional, Oshima, Junko, additional, Oshima, Shigeru, additional, Osiewacz, Heinz D, additional, Otomo, Takanobu, additional, Otsu, Kinya, additional, Ou, Jing-hsiung James, additional, Outeiro, Tiago F, additional, Ouyang, Dong-yun, additional, Ouyang, Hongjiao, additional, Overholtzer, Michael, additional, Ozbun, Michelle A, additional, Ozdinler, P Hande, additional, Ozpolat, Bulent, additional, Pacelli, Consiglia, additional, Paganetti, Paolo, additional, Page, Guylène, additional, Pages, Gilles, additional, Pagnini, Ugo, additional, Pajak, Beata, additional, Pak, Stephen C, additional, Pakos-Zebrucka, Karolina, additional, Pakpour, Nazzy, additional, Palková, Zdena, additional, Palladino, Francesca, additional, Pallauf, Kathrin, additional, Pallet, Nicolas, additional, Palmieri, Marta, additional, Paludan, Søren R, additional, Palumbo, Camilla, additional, Palumbo, Silvia, additional, Pampliega, Olatz, additional, Pan, Hongming, additional, Pan, Wei, additional, Panaretakis, Theocharis, additional, Pandey, Aseem, additional, Pantazopoulou, Areti, additional, Papackova, Zuzana, additional, Papademetrio, Daniela L, additional, Papassideri, Issidora, additional, Papini, Alessio, additional, Parajuli, Nirmala, additional, Pardo, Julian, additional, Parekh, Vrajesh V, additional, Parenti, Giancarlo, additional, Park, Jong-In, additional, Park, Junsoo, additional, Park, Ohkmae K, additional, Parker, Roy, additional, Parlato, Rosanna, additional, Parys, Jan B, additional, Parzych, Katherine R, additional, Pasquet, Jean-Max, additional, Pasquier, Benoit, additional, Pasumarthi, Kishore BS, additional, Patschan, Daniel, additional, Patterson, Cam, additional, Pattingre, Sophie, additional, Pattison, Scott, additional, Pause, Arnim, additional, Pavenstädt, Hermann, additional, Pavone, Flaminia, additional, Pedrozo, Zully, additional, Peña, Fernando J, additional, Peñalva, Miguel A, additional, Pende, Mario, additional, Peng, Jianxin, additional, Penna, Fabio, additional, Penninger, Josef M, additional, Pensalfini, Anna, additional, Pepe, Salvatore, additional, Pereira, Gustavo JS, additional, Pereira, Paulo C, additional, Pérez-de la Cruz, Verónica, additional, Pérez-Pérez, María Esther, additional, Pérez-Rodríguez, Diego, additional, Pérez-Sala, Dolores, additional, Perier, Celine, additional, Perl, Andras, additional, Perlmutter, David H, additional, Perrotta, Ida, additional, Pervaiz, Shazib, additional, Pesonen, Maija, additional, Pessin, Jeffrey E, additional, Peters, Godefridus J, additional, Petersen, Morten, additional, Petrache, Irina, additional, Petrof, Basil J, additional, Petrovski, Goran, additional, Phang, James M, additional, Piacentini, Mauro, additional, Pierdominici, Marina, additional, Pierre, Philippe, additional, Pierrefite-Carle, Valérie, additional, Pietrocola, Federico, additional, Pimentel-Muiños, Felipe X, additional, Pinar, Mario, additional, Pineda, Benjamin, additional, Pinkas-Kramarski, Ronit, additional, Pinti, Marcello, additional, Pinton, Paolo, additional, Piperdi, Bilal, additional, Piret, James M, additional, Platanias, Leonidas C, additional, Platta, Harald W, additional, Plowey, Edward D, additional, Pöggeler, Stefanie, additional, Poirot, Marc, additional, Polčic, Peter, additional, Poletti, Angelo, additional, Poon, Audrey H, additional, Popelka, Hana, additional, Popova, Blagovesta, additional, Poprawa, Izabela, additional, Poulose, Shibu M, additional, Poulton, Joanna, additional, Powers, Scott K, additional, Powers, Ted, additional, Pozuelo-Rubio, Mercedes, additional, Prak, Krisna, additional, Prange, Reinhild, additional, Prescott, Mark, additional, Priault, Muriel, additional, Prince, Sharon, additional, Proia, Richard L, additional, Proikas-Cezanne, Tassula, additional, Prokisch, Holger, additional, Promponas, Vasilis J, additional, Przyklenk, Karin, additional, Puertollano, Rosa, additional, Pugazhenthi, Subbiah, additional, Puglielli, Luigi, additional, Pujol, Aurora, additional, Puyal, Julien, additional, Pyeon, Dohun, additional, Qi, Xin, additional, Qian, Wen-bin, additional, Qin, Zheng-Hong, additional, Qiu, Yu, additional, Qu, Ziwei, additional, Quadrilatero, Joe, additional, Quinn, Frederick, additional, Raben, Nina, additional, Rabinowich, Hannah, additional, Radogna, Flavia, additional, Ragusa, Michael J, additional, Rahmani, Mohamed, additional, Raina, Komal, additional, Ramanadham, Sasanka, additional, Ramesh, Rajagopal, additional, Rami, Abdelhaq, additional, Randall-Demllo, Sarron, additional, Randow, Felix, additional, Rao, Hai, additional, Rao, V Ashutosh, additional, Rasmussen, Blake B, additional, Rasse, Tobias M, additional, Ratovitski, Edward A, additional, Rautou, Pierre-Emmanuel, additional, Ray, Swapan K, additional, Razani, Babak, additional, Reed, Bruce H, additional, Reggiori, Fulvio, additional, Rehm, Markus, additional, Reichert, Andreas S, additional, Rein, Theo, additional, Reiner, David J, additional, Reits, Eric, additional, Ren, Jun, additional, Ren, Xingcong, additional, Renna, Maurizio, additional, Reusch, Jane EB, additional, Revuelta, Jose L, additional, Reyes, Leticia, additional, Rezaie, Alireza R, additional, Richards, Robert I, additional, Richardson, Des R, additional, Richetta, Clémence, additional, Riehle, Michael A, additional, Rihn, Bertrand H, additional, Rikihisa, Yasuko, additional, Riley, Brigit E, additional, Rimbach, Gerald, additional, Rippo, Maria Rita, additional, Ritis, Konstantinos, additional, Rizzi, Federica, additional, Rizzo, Elizete, additional, Roach, Peter J, additional, Robbins, Jeffrey, additional, Roberge, Michel, additional, Roca, Gabriela, additional, Roccheri, Maria Carmela, additional, Rocha, Sonia, additional, Rodrigues, Cecilia MP, additional, Rodríguez, Clara I, additional, de Cordoba, Santiago Rodriguez, additional, Rodriguez-Muela, Natalia, additional, Roelofs, Jeroen, additional, Rogov, Vladimir V, additional, Rohn, Troy T, additional, Rohrer, Bärbel, additional, Romanelli, Davide, additional, Romani, Luigina, additional, Romano, Patricia Silvia, additional, Roncero, M Isabel G, additional, Rosa, Jose Luis, additional, Rosello, Alicia, additional, Rosen, Kirill V, additional, Rosenstiel, Philip, additional, Rost-Roszkowska, Magdalena, additional, Roth, Kevin A, additional, Roué, Gael, additional, Rouis, Mustapha, additional, Rouschop, Kasper M, additional, Ruan, Daniel T, additional, Ruano, Diego, additional, Rubinsztein, David C, additional, Rucker, Edmund B, additional, Rudich, Assaf, additional, Rudolf, Emil, additional, Rudolf, Ruediger, additional, Ruegg, Markus A, additional, Ruiz-Roldan, Carmen, additional, Ruparelia, Avnika Ashok, additional, Rusmini, Paola, additional, Russ, David W, additional, Russo, Gian Luigi, additional, Russo, Giuseppe, additional, Russo, Rossella, additional, Rusten, Tor Erik, additional, Ryabovol, Victoria, additional, Ryan, Kevin M, additional, Ryter, Stefan W, additional, Sabatini, David M, additional, Sacher, Michael, additional, Sachse, Carsten, additional, Sack, Michael N, additional, Sadoshima, Junichi, additional, Saftig, Paul, additional, Sagi-Eisenberg, Ronit, additional, Sahni, Sumit, additional, Saikumar, Pothana, additional, Saito, Tsunenori, additional, Saitoh, Tatsuya, additional, Sakakura, Koichi, additional, Sakoh-Nakatogawa, Machiko, additional, Sakuraba, Yasuhito, additional, Salazar-Roa, María, additional, Salomoni, Paolo, additional, Saluja, Ashok K, additional, Salvaterra, Paul M, additional, Salvioli, Rosa, additional, Samali, Afshin, additional, Sanchez, Anthony MJ, additional, Sánchez-Alcázar, José A, additional, Sanchez-Prieto, Ricardo, additional, Sandri, Marco, additional, Sanjuan, Miguel A, additional, Santaguida, Stefano, additional, Santambrogio, Laura, additional, Santoni, Giorgio, additional, dos Santos, Claudia Nunes, additional, Saran, Shweta, additional, Sardiello, Marco, additional, Sargent, Graeme, additional, Sarkar, Pallabi, additional, Sarkar, Sovan, additional, Sarrias, Maria Rosa, additional, Sarwal, Minnie M, additional, Sasakawa, Chihiro, additional, Sasaki, Motoko, additional, Sass, Miklos, additional, Sato, Ken, additional, Sato, Miyuki, additional, Satriano, Joseph, additional, Savaraj, Niramol, additional, Saveljeva, Svetlana, additional, Schaefer, Liliana, additional, Schaible, Ulrich E, additional, Scharl, Michael, additional, Schatzl, Hermann M, additional, Schekman, Randy, additional, Scheper, Wiep, additional, Schiavi, Alfonso, additional, Schipper, Hyman M, additional, Schmeisser, Hana, additional, Schmidt, Jens, additional, Schmitz, Ingo, additional, Schneider, Bianca E, additional, Schneider, E Marion, additional, Schneider, Jaime L, additional, Schon, Eric A, additional, Schönenberger, Miriam J, additional, Schönthal, Axel H, additional, Schorderet, Daniel F, additional, Schröder, Bernd, additional, Schuck, Sebastian, additional, Schulze, Ryan J, additional, Schwarten, Melanie, additional, Schwarz, Thomas L, additional, Sciarretta, Sebastiano, additional, Scotto, Kathleen, additional, Scovassi, A Ivana, additional, Screaton, Robert A, additional, Screen, Mark, additional, Seca, Hugo, additional, Sedej, Simon, additional, Segatori, Laura, additional, Segev, Nava, additional, Seglen, Per O, additional, Seguí-Simarro, Jose M, additional, Segura-Aguilar, Juan, additional, Seki, Ekihiro, additional, Seiliez, Iban, additional, Sell, Christian, additional, Semenkovich, Clay F, additional, Semenza, Gregg L, additional, Sen, Utpal, additional, Serra, Andreas L, additional, Serrano-Puebla, Ana, additional, Sesaki, Hiromi, additional, Setoguchi, Takao, additional, Settembre, Carmine, additional, Shacka, John J, additional, Shajahan-Haq, Ayesha N, additional, Shapiro, Irving M, additional, Sharma, Shweta, additional, She, Hua, additional, Shen, C-K James, additional, Shen, Chiung-Chyi, additional, Shen, Han-Ming, additional, Shen, Sanbing, additional, Shen, Weili, additional, Sheng, Rui, additional, Sheng, Xianyong, additional, Sheng, Zu-Hang, additional, Shepherd, Trevor G, additional, Shi, Junyan, additional, Shi, Qiang, additional, Shi, Qinghua, additional, Shi, Yuguang, additional, Shibutani, Shusaku, additional, Shibuya, Kenichi, additional, Shidoji, Yoshihiro, additional, Shieh, Jeng-Jer, additional, Shih, Chwen-Ming, additional, Shimada, Yohta, additional, Shimizu, Shigeomi, additional, Shin, Dong Wook, additional, Shinohara, Mari L, additional, Shintani, Michiko, additional, Shintani, Takahiro, additional, Shioi, Tetsuo, additional, Shirabe, Ken, additional, Shiri-Sverdlov, Ronit, additional, Shirihai, Orian, additional, Shore, Gordon C, additional, Shu, Chih-Wen, additional, Shukla, Deepak, additional, Sibirny, Andriy A, additional, Sica, Valentina, additional, Sigurdson, Christina J, additional, Sigurdsson, Einar M, additional, Sijwali, Puran Singh, additional, Sikorska, Beata, additional, Silveira, Wilian A, additional, Silvente-Poirot, Sandrine, additional, Silverman, Gary A, additional, Simak, Jan, additional, Simmet, Thomas, additional, Simon, Anna Katharina, additional, Simon, Hans-Uwe, additional, Simone, Cristiano, additional, Simons, Matias, additional, Simonsen, Anne, additional, Singh, Rajat, additional, Singh, Shivendra V, additional, Singh, Shrawan K, additional, Sinha, Debasish, additional, Sinha, Sangita, additional, Sinicrope, Frank A, additional, Sirko, Agnieszka, additional, Sirohi, Kapil, additional, Sishi, Balindiwe JN, additional, Sittler, Annie, additional, Siu, Parco M, additional, Sivridis, Efthimios, additional, Skwarska, Anna, additional, Slack, Ruth, additional, Slaninová, Iva, additional, Slavov, Nikolai, additional, Smaili, Soraya S, additional, Smalley, Keiran SM, additional, Smith, Duncan R, additional, Soenen, Stefaan J, additional, Soleimanpour, Scott A, additional, Solhaug, Anita, additional, Somasundaram, Kumaravel, additional, Son, Jin H, additional, Sonawane, Avinash, additional, Song, Chunjuan, additional, Song, Fuyong, additional, Song, Hyun Kyu, additional, Song, Ju-Xian, additional, Song, Wei, additional, Soo, Kai Y, additional, Sood, Anil K, additional, Soong, Tuck Wah, additional, Soontornniyomkij, Virawudh, additional, Sorice, Maurizio, additional, Sotgia, Federica, additional, Soto-Pantoja, David R, additional, Sotthibundhu, Areechun, additional, Sousa, Maria João, additional, Spaink, Herman P, additional, Span, Paul N, additional, Spang, Anne, additional, Sparks, Janet D, additional, Speck, Peter G, additional, Spector, Stephen A, additional, Spies, Claudia D, additional, Springer, Wolfdieter, additional, Clair, Daret St, additional, Stacchiotti, Alessandra, additional, Staels, Bart, additional, Stang, Michael T, additional, Starczynowski, Daniel T, additional, Starokadomskyy, Petro, additional, Steegborn, Clemens, additional, Steele, John W, additional, Stefanis, Leonidas, additional, Steffan, Joan, additional, Stellrecht, Christine M, additional, Stenmark, Harald, additional, Stepkowski, Tomasz M, additional, Stern, Stęphan T, additional, Stevens, Craig, additional, Stockwell, Brent R, additional, Stoka, Veronika, additional, Storchova, Zuzana, additional, Stork, Björn, additional, Stratoulias, Vassilis, additional, Stravopodis, Dimitrios J, additional, Strnad, Pavel, additional, Strohecker, Anne Marie, additional, Ström, Anna-Lena, additional, Stromhaug, Per, additional, Stulik, Jiri, additional, Su, Yu-Xiong, additional, Su, Zhaoliang, additional, Subauste, Carlos S, additional, Subramaniam, Srinivasa, additional, Sue, Carolyn M, additional, Suh, Sang Won, additional, Sui, Xinbing, additional, Sukseree, Supawadee, additional, Sulzer, David, additional, Sun, Fang-Lin, additional, Sun, Jiaren, additional, Sun, Jun, additional, Sun, Shi-Yong, additional, Sun, Yang, additional, Sun, Yi, additional, Sun, Yingjie, additional, Sundaramoorthy, Vinod, additional, Sung, Joseph, additional, Suzuki, Hidekazu, additional, Suzuki, Kuninori, additional, Suzuki, Naoki, additional, Suzuki, Tadashi, additional, Suzuki, Yuichiro J, additional, Swanson, Michele S, additional, Swanton, Charles, additional, Swärd, Karl, additional, Swarup, Ghanshyam, additional, Sweeney, Sean T, additional, Sylvester, Paul W, additional, Szatmari, Zsuzsanna, additional, Szegezdi, Eva, additional, Szlosarek, Peter W, additional, Taegtmeyer, Heinrich, additional, Tafani, Marco, additional, Taillebourg, Emmanuel, additional, Tait, Stephen WG, additional, Takacs-Vellai, Krisztina, additional, Takahashi, Yoshinori, additional, Takáts, Szabolcs, additional, Takemura, Genzou, additional, Takigawa, Nagio, additional, Talbot, Nicholas J, additional, Tamagno, Elena, additional, Tamburini, Jerome, additional, Tan, Cai-Ping, additional, Tan, Lan, additional, Tan, Mei Lan, additional, Tan, Ming, additional, Tan, Yee-Joo, additional, Tanaka, Keiji, additional, Tanaka, Masaki, additional, Tang, Daolin, additional, Tang, Dingzhong, additional, Tang, Guomei, additional, Tanida, Isei, additional, Tanji, Kunikazu, additional, Tannous, Bakhos A, additional, Tapia, Jose A, additional, Tasset-Cuevas, Inmaculada, additional, Tatar, Marc, additional, Tavassoly, Iman, additional, Tavernarakis, Nektarios, additional, Taylor, Allen, additional, Taylor, Graham S, additional, Taylor, Gregory A, additional, Taylor, J Paul, additional, Taylor, Mark J, additional, Tchetina, Elena V, additional, Tee, Andrew R, additional, Teixeira-Clerc, Fatima, additional, Telang, Sucheta, additional, Tencomnao, Tewin, additional, Teng, Ba-Bie, additional, Teng, Ru-Jeng, additional, Terro, Faraj, additional, Tettamanti, Gianluca, additional, Theiss, Arianne L, additional, Theron, Anne E, additional, Thomas, Kelly Jean, additional, Thomé, Marcos P, additional, Thomes, Paul G, additional, Thorburn, Andrew, additional, Thorner, Jeremy, additional, Thum, Thomas, additional, Thumm, Michael, additional, Thurston, Teresa LM, additional, Tian, Ling, additional, Till, Andreas, additional, Ting, Jenny Pan-yun, additional, Titorenko, Vladimir I, additional, Toker, Lilach, additional, Toldo, Stefano, additional, Tooze, Sharon A, additional, Topisirovic, Ivan, additional, Torgersen, Maria Lyngaas, additional, Torosantucci, Liliana, additional, Torriglia, Alicia, additional, Torrisi, Maria Rosaria, additional, Tournier, Cathy, additional, Towns, Roberto, additional, Trajkovic, Vladimir, additional, Travassos, Leonardo H, additional, Triola, Gemma, additional, Tripathi, Durga Nand, additional, Trisciuoglio, Daniela, additional, Troncoso, Rodrigo, additional, Trougakos, Ioannis P, additional, Truttmann, Anita C, additional, Tsai, Kuen-Jer, additional, Tschan, Mario P, additional, Tseng, Yi-Hsin, additional, Tsukuba, Takayuki, additional, Tsung, Allan, additional, Tsvetkov, Andrey S, additional, Tu, Shuiping, additional, Tuan, Hsing-Yu, additional, Tucci, Marco, additional, Tumbarello, David A, additional, Turk, Boris, additional, Turk, Vito, additional, Turner, Robin FB, additional, Tveita, Anders A, additional, Tyagi, Suresh C, additional, Ubukata, Makoto, additional, Uchiyama, Yasuo, additional, Udelnow, Andrej, additional, Ueno, Takashi, additional, Umekawa, Midori, additional, Umemiya-Shirafuji, Rika, additional, Underwood, Benjamin R, additional, Ungermann, Christian, additional, Ureshino, Rodrigo P., additional, Ushioda, Ryo, additional, Uversky, Vladimir N, additional, Uzcátegui, Néstor L, additional, Vaccari, Thomas, additional, Vaccaro, Maria I, additional, Váchová, Libuše, additional, Vakifahmetoglu-Norberg, Helin, additional, Valdor, Rut, additional, Valente, Enza Maria, additional, Vallette, Francois, additional, Valverde, Angela M, additional, Van den Berghe, Greet, additional, Van Den Bosch, Ludo, additional, van den Brink, Gijs R, additional, van der Goot, F Gisou, additional, van der Klei, Ida J, additional, van der Laan, Luc JW, additional, van Doorn, Wouter G, additional, van Egmond, Marjolein, additional, van Golen, Kenneth L, additional, Van Kaer, Luc, additional, van Lookeren Campagne, Menno, additional, Vandenabeele, Peter, additional, Vandenberghe, Wim, additional, Vanhorebeek, Ilse, additional, Varela-Nieto, Isabel, additional, Vasconcelos, M Helena, additional, Vasko, Radovan, additional, Vavvas, Demetrios G, additional, Vega-Naredo, Ignacio, additional, Velasco, Guillermo, additional, Velentzas, Athanassios D, additional, Velentzas, Panagiotis D, additional, Vellai, Tibor, additional, Vellenga, Edo, additional, Vendelbo, Mikkel Holm, additional, Venkatachalam, Kartik, additional, Ventura, Natascia, additional, Ventura, Salvador, additional, Veras, Patrícia ST, additional, Verdier, Mireille, additional, Vertessy, Beata G, additional, Viale, Andrea, additional, Vidal, Michel, additional, Vieira, Helena LA, additional, Vierstra, Richard D, additional, Vigneswaran, Nadarajah, additional, Vij, Neeraj, additional, Vila, Miquel, additional, Villar, Margarita, additional, Villar, Victor H, additional, Villarroya, Joan, additional, Vindis, Cécile, additional, Viola, Giampietro, additional, Viscomi, Maria Teresa, additional, Vitale, Giovanni, additional, Vogl, Dan T, additional, Voitsekhovskaja, Olga V, additional, von Haefen, Clarissa, additional, von Schwarzenberg, Karin, additional, Voth, Daniel E, additional, Vouret-Craviari, Valérie, additional, Vuori, Kristina, additional, Vyas, Jatin M, additional, Waeber, Christian, additional, Walker, Cheryl Lyn, additional, Walker, Mark J, additional, Walter, Jochen, additional, Wan, Lei, additional, Wan, Xiangbo, additional, Wang, Bo, additional, Wang, Caihong, additional, Wang, Chao-Yung, additional, Wang, Chengshu, additional, Wang, Chenran, additional, Wang, Chuangui, additional, Wang, Dong, additional, Wang, Fen, additional, Wang, Fuxin, additional, Wang, Guanghui, additional, Wang, Hai-jie, additional, Wang, Haichao, additional, Wang, Hong-Gang, additional, Wang, Hongmin, additional, Wang, Horng-Dar, additional, Wang, Jing, additional, Wang, Junjun, additional, Wang, Mei, additional, Wang, Mei-Qing, additional, Wang, Pei-Yu, additional, Wang, Peng, additional, Wang, Richard C, additional, Wang, Shuo, additional, Wang, Ting-Fang, additional, Wang, Xian, additional, Wang, Xiao-jia, additional, Wang, Xiao-Wei, additional, Wang, Xin, additional, Wang, Xuejun, additional, Wang, Yan, additional, Wang, Yanming, additional, Wang, Ying, additional, Wang, Ying-Jan, additional, Wang, Yipeng, additional, Wang, Yu, additional, Wang, Yu Tian, additional, Wang, Yuqing, additional, Wang, Zhi-Nong, additional, Wappner, Pablo, additional, Ward, Carl, additional, Ward, Diane McVey, additional, Warnes, Gary, additional, Watada, Hirotaka, additional, Watanabe, Yoshihisa, additional, Watase, Kei, additional, Weaver, Timothy E, additional, Weekes, Colin D, additional, Wei, Jiwu, additional, Weide, Thomas, additional, Weihl, Conrad C, additional, Weindl, Günther, additional, Weis, Simone Nardin, additional, Wen, Longping, additional, Wen, Xin, additional, Wen, Yunfei, additional, Westermann, Benedikt, additional, Weyand, Cornelia M, additional, White, Anthony R, additional, White, Eileen, additional, Whitton, J Lindsay, additional, Whitworth, Alexander J, additional, Wiels, Joëlle, additional, Wild, Franziska, additional, Wildenberg, Manon E, additional, Wileman, Tom, additional, Wilkinson, Deepti Srinivas, additional, Wilkinson, Simon, additional, Willbold, Dieter, additional, Williams, Chris, additional, Williams, Katherine, additional, Williamson, Peter R, additional, Winklhofer, Konstanze F, additional, Witkin, Steven S, additional, Wohlgemuth, Stephanie E, additional, Wollert, Thomas, additional, Wolvetang, Ernst J, additional, Wong, Esther, additional, Wong, G William, additional, Wong, Richard W, additional, Wong, Vincent Kam Wai, additional, Woodcock, Elizabeth A, additional, Wright, Karen L, additional, Wu, Chunlai, additional, Wu, Defeng, additional, Wu, Gen Sheng, additional, Wu, Jian, additional, Wu, Junfang, additional, Wu, Mian, additional, Wu, Min, additional, Wu, Shengzhou, additional, Wu, William KK, additional, Wu, Yaohua, additional, Wu, Zhenlong, additional, Xavier, Cristina PR, additional, Xavier, Ramnik J, additional, Xia, Gui-Xian, additional, Xia, Tian, additional, Xia, Weiliang, additional, Xia, Yong, additional, Xiao, Hengyi, additional, Xiao, Jian, additional, Xiao, Shi, additional, Xiao, Wuhan, additional, Xie, Chuan-Ming, additional, Xie, Zhiping, additional, Xie, Zhonglin, additional, Xilouri, Maria, additional, Xiong, Yuyan, additional, Xu, Chuanshan, additional, Xu, Congfeng, additional, Xu, Feng, additional, Xu, Haoxing, additional, Xu, Hongwei, additional, Xu, Jian, additional, Xu, Jianzhen, additional, Xu, Jinxian, additional, Xu, Liang, additional, Xu, Xiaolei, additional, Xu, Yangqing, additional, Xu, Ye, additional, Xu, Zhi-Xiang, additional, Xu, Ziheng, additional, Xue, Yu, additional, Yamada, Takahiro, additional, Yamamoto, Ai, additional, Yamanaka, Koji, additional, Yamashina, Shunhei, additional, Yamashiro, Shigeko, additional, Yan, Bing, additional, Yan, Bo, additional, Yan, Xianghua, additional, Yan, Zhen, additional, Yanagi, Yasuo, additional, Yang, Dun-Sheng, additional, Yang, Jin-Ming, additional, Yang, Liu, additional, Yang, Minghua, additional, Yang, Pei-Ming, additional, Yang, Peixin, additional, Yang, Qian, additional, Yang, Wannian, additional, Yang, Wei Yuan, additional, Yang, Xuesong, additional, Yang, Yi, additional, Yang, Ying, additional, Yang, Zhifen, additional, Yang, Zhihong, additional, Yao, Meng-Chao, additional, Yao, Pamela J, additional, Yao, Xiaofeng, additional, Yao, Zhenyu, additional, Yao, Zhiyuan, additional, Yasui, Linda S, additional, Ye, Mingxiang, additional, Yedvobnick, Barry, additional, Yeganeh, Behzad, additional, Yeh, Elizabeth S, additional, Yeyati, Patricia L, additional, Yi, Fan, additional, Yi, Long, additional, Yin, Xiao-Ming, additional, Yip, Calvin K, additional, Yoo, Yeong-Min, additional, Yoo, Young Hyun, additional, Yoon, Seung-Yong, additional, Yoshida, Ken-Ichi, additional, Yoshimori, Tamotsu, additional, Young, Ken H, additional, Yu, Huixin, additional, Yu, Jane J, additional, Yu, Jin-Tai, additional, Yu, Jun, additional, Yu, Li, additional, Yu, W Haung, additional, Yu, Xiao-Fang, additional, Yu, Zhengping, additional, Yuan, Junying, additional, Yuan, Zhi-Min, additional, Yue, Beatrice YJT, additional, Yue, Jianbo, additional, Yue, Zhenyu, additional, Zacks, David N, additional, Zacksenhaus, Eldad, additional, Zaffaroni, Nadia, additional, Zaglia, Tania, additional, Zakeri, Zahra, additional, Zecchini, Vincent, additional, Zeng, Jinsheng, additional, Zeng, Min, additional, Zeng, Qi, additional, Zervos, Antonis S, additional, Zhang, Donna D, additional, Zhang, Fan, additional, Zhang, Guo, additional, Zhang, Guo-Chang, additional, Zhang, Hao, additional, Zhang, Hong, additional, Zhang, Hongbing, additional, Zhang, Jian, additional, Zhang, Jiangwei, additional, Zhang, Jianhua, additional, Zhang, Jing-pu, additional, Zhang, Li, additional, Zhang, Lin, additional, Zhang, Long, additional, Zhang, Ming-Yong, additional, Zhang, Xiangnan, additional, Zhang, Xu Dong, additional, Zhang, Yan, additional, Zhang, Yang, additional, Zhang, Yanjin, additional, Zhang, Yingmei, additional, Zhang, Yunjiao, additional, Zhao, Mei, additional, Zhao, Wei-Li, additional, Zhao, Xiaonan, additional, Zhao, Yan G, additional, Zhao, Ying, additional, Zhao, Yongchao, additional, Zhao, Yu-xia, additional, Zhao, Zhendong, additional, Zhao, Zhizhuang J, additional, Zheng, Dexian, additional, Zheng, Xi-Long, additional, Zheng, Xiaoxiang, additional, Zhivotovsky, Boris, additional, Zhong, Qing, additional, Zhou, Guang-Zhou, additional, Zhou, Guofei, additional, Zhou, Huiping, additional, Zhou, Shu-Feng, additional, Zhou, Xu-jie, additional, Zhu, Hongxin, additional, Zhu, Hua, additional, Zhu, Wei-Guo, additional, Zhu, Wenhua, additional, Zhu, Xiao-Feng, additional, Zhu, Yuhua, additional, Zhuang, Shi-Mei, additional, Zhuang, Xiaohong, additional, Ziparo, Elio, additional, Zois, Christos E, additional, Zoladek, Teresa, additional, Zong, Wei-Xing, additional, Zorzano, Antonio, additional, and Zughaier, Susu M, additional
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- 2016
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24. Inactivation of autophagy ameliorates glucocorticoid-induced and ovariectomy-induced bone loss
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Lin, Neng-Yu, primary, Chen, Chih-Wei, additional, Kagwiria, Rosebeth, additional, Liang, Ruifang, additional, Beyer, Christian, additional, Distler, Alfiya, additional, Luther, Julia, additional, Engelke, Klaus, additional, Schett, Georg, additional, and Distler, Jörg HW, additional
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- 2015
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25. Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages
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Beyer, Christian, primary, Huang, Jingang, additional, Beer, Jürgen, additional, Zhang, Yun, additional, Palumbo-Zerr, Katrin, additional, Zerr, Pawel, additional, Distler, Alfiya, additional, Dees, Clara, additional, Maier, Christiane, additional, Munoz, Louis, additional, Krönke, Gerhard, additional, Uderhardt, Stefan, additional, Distler, Oliver, additional, Jones, Simon, additional, Rose-John, Stefan, additional, Oravecz, Tamas, additional, Schett, Georg, additional, and Distler, Jörg HW, additional
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- 2014
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26. Mitogen-activated protein kinase 2 regulates physiological and pathological bone turnover
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Braun, Tobias, primary, Lepper, Johannes, additional, Ruiz Heiland, Gisela, additional, Hofstetter, Willy, additional, Siegrist, Mark, additional, Lezuo, Patrick, additional, Gaestel, Matthias, additional, Rumpler, Monika, additional, Thaler, Roman, additional, Klaushofer, Klaus, additional, Distler, Jörg HW, additional, Schett, Georg, additional, and Zwerina, Jochen, additional
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- 2013
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27. Inhibition of Notch1 promotes hedgehog signalling in a HES1-dependent manner in chondrocytes and exacerbates experimental osteoarthritis.
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Neng-Yu Lin, Distler, Alfiya, Beyer, Christian, Philipi-Schöbinger, Ariella, Breda, Silvia, Dees, Clara, Stock, Michael, Tomcik, Michal, Niemeier, Andreas, Dell'Accio, Francesco, Gelse, Kolja, Mattson, Mark P., Schett, Georg, Distler, Jörg H. W., Lin, Neng-Yu, and Distler, Jörg Hw
- Subjects
ANIMALS ,ARTHRITIS ,ARTICULAR cartilage ,CARRIER proteins ,CARTILAGE cells ,CELL receptors ,CELLULAR signal transduction ,METAPLASTIC ossification ,MICE ,OSTEOARTHRITIS ,POLYMERASE chain reaction ,RESEARCH funding ,SEVERITY of illness index ,MEMBRANE glycoproteins - Abstract
Objectives: Notch ligands and receptors have recently been shown to be differentially expressed in osteoarthritis (OA). We aim to further elucidate the functional role of Notch signalling in OA using Notch1 antisense transgenic (Notch1 AS) mice.Methods: Notch and hedgehog signalling were analysed by real-time PCR and immunohistochemistry. Notch-1 AS mice were employed as a model of impaired Notch signalling in vivo. Experimental OA was induced by destabilisation of the medial meniscus (DMM). The extent of cartilage destruction and osteophyte formation was analysed by safranin-O staining with subsequent assessment of the Osteoarthritis Research Society International (OARSI) and Mankin scores and µCT scanning. Collagen X staining was used as a marker of chondrocyte hypertrophy. The role of hairy/enhancer of split 1 (Hes-1) was investigated with knockdown and overexpression experiments.Results: Notch signalling was activated in human and murine OA with increased expression of Jagged1, Notch-1, accumulation of the Notch intracellular domain 1 and increased transcription of Hes-1. Notch1 AS mice showed exacerbated OA with increases in OARSI scores, osteophyte formation, increased subchondral bone plate density, collagen X and osteocalcin expression and elevated levels of Epas1 and ADAM-TS5 mRNA. Inhibition of the Notch pathway induced activation of hedgehog signalling with induction of Gli-1 and Gli-2 and increased transcription of hedgehog target genes. The regulatory effects of Notch signalling on Gli-expression were mimicked by Hes-1.Conclusions: Inhibition of Notch signalling activates hedgehog signalling, enhances chondrocyte hypertrophy and exacerbates experimental OA including osteophyte formation. These data suggest that the activation of the Notch pathway may limit aberrant hedgehog signalling in OA. [ABSTRACT FROM AUTHOR]- Published
- 2016
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28. Inactivation of autophagy ameliorates glucocorticoid-induced and ovariectomy-induced bone loss.
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Neng-Yu Lin, Chih-Wei Chen, Kagwiria, Rosebeth, Ruifang Liang, Beyer, Christian, Distler, Alfiya, Luther, Julia, Engelke, Klaus, Schett, Georg, Distler, Jörg H. W., Lin, Neng-Yu, Chen, Chih-Wei, Liang, Ruifang, and Distler, Jörg Hw
- Abstract
Objectives: Autophagy has recently been shown to regulate osteoclast activity and osteoclast differentiation. Here, we aim to investigate the impact of autophagy inhibition as a potential therapeutic approach for the treatment of osteoporosis in preclinical models.Methods: Systemic bone loss was induced in mice by glucocorticoids and by ovariectomy (OVX). Autophagy was targeted by conditional inactivation of autophagy-related gene 7 (Atg7) and by treatment with chloroquine (CQ). Bone density was evaluated by microCT. The role of autophagy on osteoclastogenesis was analysed by osteoclastogenesis and bone resorption assays. The quantification of receptor activator of nuclear factor κ B ligand and osteoprotegerin proteins in cocultures was performed using ELISA whereas that of osteoclast and osteoblast differentiation markers was by qPCR.Results: Selective deletion of Atg7 in monocytes from Atg7(fl/fl)_x_LysM-Cre mice mitigated glucocorticoid-induced and OVX-induced osteoclast differentiation and bone loss compared with Atg7(fl/fl) littermates. Pharmacological inhibition of autophagy by treatment with CQ suppressed glucocorticoid-induced osteoclastogenesis and protected mice from bone loss. Similarly, inactivation of autophagy shielded mice from OVX-induced bone loss. Inhibition of autophagy led to decreased osteoclast differentiation with lower expression of osteoclast markers such as NFATc1, tartrate-resistant acid phosphatase, OSCAR and cathepsin K and attenuated bone resorption in vitro. In contrast, osteoblast differentiation was not affected by inhibition of autophagy.Conclusions: Pharmacological or genetic inactivation of autophagy ameliorated glucocorticoid-induced and OVX-induced bone loss by inhibiting osteoclastogenesis. These findings may have direct translational implications for the treatment of osteoporosis, since inhibitors of autophagy such as CQ are already in clinical use. [ABSTRACT FROM AUTHOR]- Published
- 2016
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29. Liver X receptors orchestrate osteoblast/osteoclast crosstalk and counteract pathologic bone loss
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Kleyer, Arnd, primary, Scholtysek, Carina, additional, Bottesch, Edith, additional, Hillienhof, Ulrike, additional, Beyer, Christian, additional, Distler, Jörg HW, additional, Tuckermann, Jan P, additional, Schett, Georg, additional, and Krönke, Gerhard, additional
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- 2012
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30. WNT5A is induced by inflammatory mediators in bone marrow stromal cells and regulates cytokine and chemokine production
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Rauner, Martina, primary, Stein, Nicola, additional, Winzer, Maria, additional, Goettsch, Claudia, additional, Zwerina, Jochen, additional, Schett, Georg, additional, Distler, Jörg HW, additional, Albers, Joachim, additional, Schulze, Jochen, additional, Schinke, Thorsten, additional, Bornhäuser, Martin, additional, Platzbecker, Uwe, additional, and Hofbauer, Lorenz C, additional
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- 2012
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31. The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death
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Beyer, Christian, primary, Stearns, Nancy A, additional, Giessl, Adreas, additional, Distler, Jörg HW, additional, Schett, Georg, additional, and Pisetsky, David S, additional
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- 2012
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32. Epigenetic modifications: novel therapeutic strategies for systemic sclerosis?
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Jüngel, Astrid, primary, Distler, Jörg HW, additional, Gay, Steffen, additional, and Distler, Oliver, additional
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- 2011
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33. Vascular alterations upon activation of TGFβ signaling in fibroblasts - implications for systemic sclerosis
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Horn, Angelika, primary and Distler, Jörg HW, additional
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- 2010
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34. The scientific basis for novel treatments of systemic sclerosis
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Beyer, Christian, primary and Distler, Jörg HW, additional
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- 2009
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35. Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis
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Beyer, Christian, primary, Schett, Georg, additional, Gay, Steffen, additional, Distler, Oliver, additional, and Distler, Jörg HW, additional
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- 2009
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36. Levels of target activation predict antifibrotic responses to tyrosine kinase inhibitors.
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Maurer, Britta, Distler, Alfiya, Dees, Clara, Khan, Korsa, Denton, Christopher P., Abraham, David, Gay, Renate E., Michel, Beat A., Gay, Steffen, Distler, Jörg HW, and Distler, Oliver
- Abstract
Objectives To assess whether the discrepancy between the strong antifibrotic effects of tyrosine kinase inhibitors (TKIs) in animal models and the inconsistent results in clinical studies might be related to the activation levels of drug targets. Methods Skin sections of bleomycin, TSK1, Fra-2 transgenic mice, SSc patients and controls were analysed by histology and immunohistochemistry. Subgroups of mice were treated with the TKIs nilotinib or imatinib. Differences in the activation levels of the TKI targets p-PDGFRβ (platelet derived growth factor β) and p-c-ab were assessed. Results In bleomycin and TSK1 mice, expression of activated p-PDGFRβ (platelet derived growth factor receptor β) and p-c-abl was ubiquitous with strong upregulation compared with controls. Treatment with TKIs resulted in successful target inhibition and consequently reduced dermal fibrosis. In the Fra-2 model, the activation levels of p-PDGFRβ and p-c-abl were much lower than in the bleomycin and the TSK1 models. Accordingly, nilotinib did not prevent dermal fibrosis and target inhibition was unsuccessful. Notably, in skin biopsies of SSc patients, the mean activation levels of TKI targets were only moderate and in the majority of patients resembled those of the non-responsive Fra-2 model. Conclusions Animal models for proof-of-concept studies should be selected based on a similar activation level and expression pattern of drug targets as in human SSc. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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37. TGF-β-induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis.
- Author
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Dees, Clara, Pötter, Sebastian, Yun Zhang, Bergmann, Christina, Xiang Zhou, Luber, Markus, Wohlfahrt, Thomas, Karouzakis, Emmanuel, Ramming, Andreas, Gelse, Kolja, Akihiko Yoshimura, Jaenisch, Rudolf, Distler, Oliver, Schett, Georg, Distler, Jörg H. W., Zhang, Yun, Zhou, Xiang, Yoshimura, Akihiko, and Distler, Jörg Hw
- Subjects
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FIBROBLASTS , *GROWTH factors , *ANIMAL experimentation , *RESEARCH methodology , *SYSTEMIC scleroderma , *FIBROSIS , *EVALUATION research , *CELLULAR signal transduction , *COMPARATIVE studies , *GENES , *CARRIER proteins , *MICE - Abstract
Fibroblasts are key effector cells in tissue remodeling. They remain persistently activated in fibrotic diseases, resulting in progressive deposition of extracellular matrix. Although fibroblast activation may be initiated by external factors, prolonged activation can induce an "autonomous," self-maintaining profibrotic phenotype in fibroblasts. Accumulating evidence suggests that epigenetic alterations play a central role in establishing this persistently activated pathologic phenotype of fibroblasts. We demonstrated that in fibrotic skin of patients with systemic sclerosis (SSc), a prototypical idiopathic fibrotic disease, TGF-β induced the expression of DNA methyltransferase 3A (DNMT3A) and DNMT1 in fibroblasts in a SMAD-dependent manner to silence the expression of suppressor of cytokine signaling 3 (SOCS3) by promoter hypermethylation. Downregulation of SOCS3 facilitated activation of STAT3 to promote fibroblast-to-myofibroblast transition, collagen release, and fibrosis in vitro and in vivo. Reestablishment of the epigenetic control of STAT3 signaling by genetic or pharmacological inactivation of DNMT3A reversed the activated phenotype of SSc fibroblasts in tissue culture, inhibited TGF-β-dependent fibroblast activation, and ameliorated experimental fibrosis in murine models. These findings identify a pathway of epigenetic imprinting of fibroblasts in fibrotic disease with translational implications for the development of targeted therapies in fibrotic diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
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38. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- Author
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Daniel J. Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, Christopher M. Adams, Peter D. Adams, Khosrow Adeli, Peter J. Adhihetty, Sharon G. Adler, Galila Agam, Rajesh Agarwal, Manish K. Aghi, Maria Agnello, Patrizia Agostinis, Patricia V. Aguilar, Julio Aguirre Ghiso, Edoardo M. Airoldi, Slimane Ait Si Ali, Takahiko Akematsu, Emmanuel T. Akporiaye, Mohamed Al Rubeai, Guillermo M. Albaiceta, Chris Albanese, Diego Albani, Matthew L. Albert, Jesus Aldudo, Hana Algül, Mehrdad Alirezaei, Iraide Alloza, Alexandru Almasan, Maylin Almonte Beceril, Emad S. Alnemri, Covadonga Alonso, Nihal Altan Bonnet, Dario C. Altieri, Silvia Alvarez, Lydia Alvarez Erviti, Sandro Alves, Giuseppina Amadoro, Atsuo Amano, Consuelo Amantini, Santiago Ambrosio, Ivano Amelio, Amal O. Amer, Mohamed Amessou, Angelika Amon, Zhenyi An, Frank A. Anania, Stig U. Andersen, Usha P. Andley, Catherine K. Andreadi, Nathalie Andrieu Abadie, Alberto Anel, David K. Ann, Shailendra Anoopkumar Dukie, Manuela Antonioli, Hiroshi Aoki, Nadezda Apostolova, Saveria Aquila, Katia Aquilano, Koichi Araki, Eli Arama, Agustin Aranda, Jun Araya, Alexandre Arcaro, Esperanza Arias, Hirokazu Arimoto, Aileen R. Ariosa, Jane L. Armstrong, Thierry Arnould, Ivica Arsov, Katsuhiko Asanuma, Valerie Askanas, Eric Asselin, Ryuichiro Atarashi, Sally S. Atherton, Julie D. Atkin, Laura D. Attardi, Patrick Auberger, Georg Auburger, Laure Aurelian, Riccardo Autelli, Laura Avagliano, Maria Laura Avantaggiati, Limor Avrahami, Suresh Awale, Neelam Azad, Tiziana Bachetti, Jonathan M. Backer, Dong Hun Bae, Jae sung Bae, Ok Nam Bae, Soo Han Bae, Eric H. Baehrecke, Seung Hoon Baek, Stephen Baghdiguian, Agnieszka Bagniewska Zadworna, Hua Bai, Jie Bai, Xue Yuan Bai, Yannick Bailly, Kithiganahalli Narayanaswamy Balaji, Walter Balduini, Andrea Ballabio, Rena Balzan, Rajkumar Banerjee, Gábor Bánhegyi, Haijun Bao, Benoit Barbeau, Maria D. Barrachina, Esther Barreiro, Bonnie Bartel, Alberto Bartolomé, Diane C. Bassham, Maria Teresa Bassi, Robert C. Bast Jr, Alakananda Basu, Maria Teresa Batista, Henri Batoko, Maurizio Battino, Kyle Bauckman, Bradley L. Baumgarner, K. Ulrich Bayer, Rupert Beale, Jean François Beaulieu, George R. Beck Jr, Christoph Becker, J. David Beckham, Pierre André Bédard, Patrick J. Bednarski, Thomas J. Begley, Christian Behl, Christian Behrends, Georg MN Behrens, Kevin E. Behrns, Eloy Bejarano, Amine Belaid, Francesca Belleudi, Giovanni Bénard, Guy Berchem, Daniele Bergamaschi, Matteo Bergami, Ben Berkhout, Laura Berliocchi, Amélie Bernard, Monique Bernard, Francesca Bernassola, Anne Bertolotti, Amanda S. Bess, Sébastien Besteiro, Saverio Bettuzzi, Savita Bhalla, Shalmoli Bhattacharyya, Sujit K. Bhutia, Caroline Biagosch, Michele Wolfe Bianchi, Martine Biard Piechaczyk, Viktor Billes, Claudia Bincoletto, Baris Bingol, Sara W. Bird, Marc Bitoun, Ivana Bjedov, Craig Blackstone, Lionel Blanc, Guillermo A. Blanco, Heidi Kiil Blomhoff, Emilio Boada Romero, Stefan Böckler, Marianne Boes, Kathleen Boesze Battaglia, Lawrence H. Boise, Alessandra Bolino, Andrea Boman, Paolo Bonaldo, Matteo Bordi, Jürgen Bosch, Luis M. Botana, Joelle Botti, German Bou, Marina Bouché, Marion Bouchecareilh, Marie Josée Boucher, Michael E. Boulton, Sebastien G. Bouret, Patricia Boya, Michaël Boyer Guittaut, Peter V. Bozhkov, Nathan Brady, Vania MM Braga, Claudio Brancolini, Gerhard H. Braus, José M. Bravo San Pedro, Lisa A. Brennan, Emery H. Bresnick, Patrick Brest, Dave Bridges, MarieAgnès Bringer, Marisa Brini, Glauber C. Brito, Bertha Brodin, Paul S. Brookes, Eric J. Brown, Karen Brown, Hal E. Broxmeyer, Alain Bruhat, Patricia Chakur Brum, John H. Brumell, Nicola Brunetti Pierri, Robert J. Bryson Richardson, Shilpa Buch, Alastair M. Buchan, Hikmet Budak, Dmitry V. Bulavin, Scott J. Bultman, Geert Bultynck, Vladimir Bumbasirevic, Yan Burelle, Robert E. Burke, Margit Burmeister, Peter Bütikofer, Laura Caberlotto, Ken Cadwell, Monika Cahova, Dongsheng Cai, Jingjing Cai, Qian Cai, Sara Calatayud, Nadine Camougrand, Michelangelo Campanella, Grant R. Campbell, Matthew Campbell, Silvia Campello, Robin Candau, Isabella Caniggia, Lavinia Cantoni, Lizhi Cao, Allan B. Caplan, Michele Caraglia, Claudio Cardinali, Sandra Morais Cardoso, Jennifer S. Carew, Laura A. Carleton, Cathleen R. Carlin, Silvia Carloni, Sven R. Carlsson, Didac Carmona Gutierrez, Leticia AM Carneiro, Oliana Carnevali, Serena Carra, Alice Carrier, Bernadette Carroll, Caty Casas, Josefina Casas, Giuliana Cassinelli, Perrine Castets, Susana Castro Obregon, Gabriella Cavallini, Isabella Ceccherini, Francesco Cecconi, Arthur I. Cederbaum, Valentín Ceña, Simone Cenci, Claudia Cerella, Davide Cervia, CETRULLO, SILVIA, Hassan Chaachouay, Han Jung Chae, Andrei S. Chagin, Chee Yin Chai, Gopal Chakrabarti, Georgios Chamilos, Edmond YW Chan, Matthew TV Chan, Dhyan Chandra, Pallavi Chandra, Chih Peng Chang, Raymond Chuen Chung Chang, Ta Yuan Chang, John C. Chatham, Saurabh Chatterjee, Santosh Chauhan, Yongsheng Che, Michael E. Cheetham, Rajkumar Cheluvappa, Chun Jung Chen, Gang Chen, Guang Chao Chen, Guoqiang Chen, Hongzhuan Chen, Jeff W. Chen, Jian Kang Chen, Min Chen, Mingzhou Chen, Peiwen Chen, Qi Chen, Quan Chen, Shang Der Chen, Si Chen, Steve S. L. Chen, Wei Chen, Wei Jung Chen, Wen Qiang Chen, Wenli Chen, Xiangmei Chen, Yau Hung Chen, Ye Guang Chen, Yin Chen, Yingyu Chen, Yongshun Chen, Yu Jen Chen, Yue Qin Chen, Yujie Chen, Zhen Chen, Zhong Chen, Alan Cheng, Christopher HK Cheng, Hua Cheng, Heesun Cheong, Sara Cherry, Jason Chesney, Chun Hei Antonio Cheung, Eric Chevet, Hsiang Cheng Chi, Sung Gil Chi, Fulvio Chiacchiera, Hui Ling Chiang, Roberto Chiarelli, Mario Chiariello, Marcello Chieppa, Lih Shen Chin, Mario Chiong, Gigi NC Chiu, Dong Hyung Cho, Ssang Goo Cho, William C. Cho, Yong Yeon Cho, Young Seok Cho, Augustine MK Choi, Eui Ju Choi, Eun Kyoung Choi, Jayoung Choi, Mary E. Choi, Seung Il Choi, Tsui Fen Chou, Salem Chouaib, Divaker Choubey, Vinay Choubey, Kuan Chih Chow, Kamal Chowdhury, Charleen T. Chu, Tsung Hsien Chuang, Taehoon Chun, Hyewon Chung, Taijoon Chung, Yuen Li Chung, Yong Joon Chwae, Valentina Cianfanelli, Roberto Ciarcia, Iwona A. Ciechomska, Maria Rosa Ciriolo, Mara Cirone, Sofie Claerhout, Michael J. Clague, Joan Clària, Peter GH Clarke, Robert Clarke, Emilio Clementi, Cédric Cleyrat, Miriam Cnop, Eliana M. Coccia, Tiziana Cocco, Patrice Codogno, Jörn Coers, Ezra EW Cohen, David Colecchia, Luisa Coletto, Núria S. Coll, Emma Colucci Guyon, Sergio Comincini, Maria Condello, Katherine L. Cook, Graham H. Coombs, Cynthia D. Cooper, J. Mark Cooper, Isabelle Coppens, Maria Tiziana Corasaniti, Marco Corazzari, Ramon Corbalan, Elisabeth Corcelle Termeau, Mario D. Cordero, Cristina Corral Ramos, Olga Corti, Andrea Cossarizza, Paola Costelli, Safia Costes, Susan L. Cotman, Ana Coto Montes, Sandra Cottet, Eduardo Couve, Lori R. Covey, L. Ashley Cowart, Jeffery S. Cox, Fraser P. Coxon, Carolyn B. Coyne, Mark S. Cragg, Rolf J. Craven, Tiziana Crepaldi, Jose L. Crespo, Alfredo Criollo, Valeria Crippa, Maria Teresa Cruz, Ana Maria Cuervo, Jose M. Cuezva, Taixing Cui, Pedro R. Cutillas, Mark J. Czaja, Maria F. Czyzyk Krzeska, Ruben K. Dagda, Uta Dahmen, Chunsun Dai, Wenjie Dai, Yun Dai, Kevin N. Dalby, Luisa Dalla Valle, Guillaume Dalmasso, Marcello D'Amelio, Markus Damme, Arlette Darfeuille Michaud, Catherine Dargemont, Victor M. Darley Usmar, Srinivasan Dasarathy, Biplab Dasgupta, Srikanta Dash, Crispin R. Dass, Hazel Marie Davey, Lester M. Davids, David Dávila, Roger J. Davis, Ted M. Dawson, Valina L. Dawson, Paula Daza, Jackie de Belleroche, Paul de Figueiredo, Regina Celia Bressan Queiroz de Figueiredo, José de la Fuente, Luisa De Martino, Antonella De Matteis, Guido RY De Meyer, Angelo De Milito, Mauro De Santi, Wanderley de Souza, Vincenzo De Tata, Daniela De Zio, Jayanta Debnath, Reinhard Dechant, Jean Paul Decuypere, Shane Deegan, Benjamin Dehay, Barbara Del Bello, Dominic P. Del Re, Régis Delage Mourroux, Lea MD Delbridge, Louise Deldicque, Elizabeth Delorme Axford, Yizhen Deng, Joern Dengjel, Melanie Denizot, Paul Dent, Channing J. Der, Vojo Deretic, Benoît Derrien, Eric Deutsch, Timothy P. Devarenne, Rodney J. Devenish, Sabrina Di Bartolomeo, Nicola Di Daniele, Fabio Di Domenico, Alessia Di Nardo, Simone Di Paola, Antonio Di Pietro, Livia Di Renzo, Aaron DiAntonio, Guillermo Díaz Araya, Ines Díaz Laviada, Maria T. Diaz Meco, Javier Diaz Nido, Chad A. Dickey, Robert C. Dickson, Marc Diederich, Paul Digard, Ivan Dikic, Savithrama P. Dinesh Kumar, Chan Ding, Wen Xing Ding, Zufeng Ding, Luciana Dini, Jörg HW Distler, Abhinav Diwan, Mojgan Djavaheri Mergny, Kostyantyn Dmytruk, Renwick CJ Dobson, Volker Doetsch, Karol Dokladny, Svetlana Dokudovskaya, Massimo Donadelli, X. Charlie Dong, Xiaonan Dong, Zheng Dong, Terrence M. Donohue Jr, Kelly S. Doran, Gabriella D'Orazi, Gerald W. Dorn II, Victor Dosenko, Sami Dridi, Liat Drucker, Jie Du, Li Lin Du, Lihuan Du, André du Toit, Priyamvada Dua, Lei Duan, Pu Duann, Vikash Kumar Dubey, Michael R. Duchen, Michel A. Duchosal, Helene Duez, Isabelle Dugail, Verónica I. Dumit, Mara C. Duncan, Elaine A. Dunlop, William A. Dunn Jr, Nicolas Dupont, Luc Dupuis, Raúl V. Durán, Thomas M. Durcan, Stéphane Duvezin Caubet, Umamaheswar Duvvuri, Vinay Eapen, Darius Ebrahimi Fakhari, Arnaud Echard, Leopold Eckhart, Charles L. Edelstein, Aimee L. Edinger, Ludwig Eichinger, Tobias Eisenberg, Avital Eisenberg Lerner, N. Tony Eissa, Wafik S. El Deiry, Victoria El Khoury, Zvulun Elazar, Hagit Eldar Finkelman, Chris JH Elliott, Enzo Emanuele, Urban Emmenegger, Nikolai Engedal, Anna Mart Engelbrecht, Simone Engelender, Jorrit M. Enserink, Ralf Erdmann, Jekaterina Erenpreisa, Rajaraman Eri, Jason L. Eriksen, Andreja Erman, Ricardo Escalante, Eeva Liisa Eskelinen, Lucile Espert, Lorena Esteban Martínez, Thomas J. Evans, Mario Fabri, Gemma Fabrias, Cinzia Fabrizi, Antonio Facchiano, Nils J. Færgeman, Alberto Faggioni, W. Douglas Fairlie, Chunhai Fan, Daping Fan, Jie Fan, Shengyun Fang, Manolis Fanto, Alessandro Fanzani, Thomas Farkas, Mathias Faure, Francois B. Favier, Howard Fearnhead, Massimo Federici, Erkang Fei, Tania C. Felizardo, Hua Feng, Yibin Feng, Yuchen Feng, Thomas A. Ferguson, Álvaro F. Fernández, Maite G. Fernandez Barrena, Jose C. Fernandez Checa, Arsenio Fernández López, Martin E. Fernandez Zapico, Olivier Feron, Elisabetta Ferraro, Carmen Veríssima Ferreira Halder, Laszlo Fesus, Ralph Feuer, Fabienne C. Fiesel, Eduardo C. Filippi Chiela, Giuseppe Filomeni, Gian Maria Fimia, John H. Fingert, Steven Finkbeiner, Toren Finkel, Filomena Fiorito, Paul B. Fisher, Marc Flajolet, FLAMIGNI, FLAVIO, Oliver Florey, Salvatore Florio, R. Andres Floto, Marco Folini, Carlo Follo, Edward A. Fon, Francesco Fornai, Franco Fortunato, Alessandro Fraldi, Rodrigo Franco, Arnaud Francois, Aurélie François, Lisa B. Frankel, Iain DC Fraser, Norbert Frey, Damien G. Freyssenet, Christian Frezza, Scott L. Friedman, Daniel E. Frigo, Dongxu Fu, José M. Fuentes, Juan Fueyo, Yoshio Fujitani, Yuuki Fujiwara, Mikihiro Fujiya, Mitsunori Fukuda, Simone Fulda, Carmela Fusco, Bozena Gabryel, Matthias Gaestel, Philippe Gailly, Malgorzata Gajewska, Sehamuddin Galadari, Gad Galili, Inmaculada Galindo, Maria F. Galindo, Giovanna Galliciotti, Lorenzo Galluzzi, Luca Galluzzi, Vincent Galy, Noor Gammoh, Sam Gandy, Anand K. Ganesan, Swamynathan Ganesan, Ian G. Ganley, Monique Gannagé, Fen Biao Gao, Feng Gao, Jian Xin Gao, Lorena García Nannig, Eleonora García Véscovi, Marina Garcia Macía, Carmen Garcia Ruiz, Abhishek D. Garg, Pramod Kumar Garg, Ricardo Gargini, Nils Christian Gassen, Damián Gatica, Evelina Gatti, Julie Gavard, Evripidis Gavathiotis, Liang Ge, Pengfei Ge, Shengfang Ge, Po Wu Gean, Vania Gelmetti, Armando A. Genazzani, Jiefei Geng, Pascal Genschik, Lisa Gerner, Jason E. Gestwicki, David A. Gewirtz, Saeid Ghavami, Eric Ghigo, Debabrata Ghosh, Anna Maria Giammarioli, Francesca Giampieri, Claudia Giampietri, Alexandra Giatromanolaki, Derrick J. Gibbings, Lara Gibellini, Spencer B. Gibson, Vanessa Ginet, Antonio Giordano, Flaviano Giorgini, Elisa Giovannetti, Stephen E. Girardin, Suzana Gispert, Sandy Giuliano, Candece L. Gladson, Alvaro Glavic, Martin Gleave, Nelly Godefroy, Robert M. Gogal Jr, Kuppan Gokulan, Gustavo H. Goldman, Delia Goletti, Michael S. Goligorsky, Aldrin V. Gomes, Ligia C. Gomes, Hernando Gomez, Candelaria Gomez Manzano, Rubén Gómez Sánchez, Dawit AP Gonçalves, Ebru Goncu, Qingqiu Gong, Céline Gongora, Carlos B. Gonzalez, Pedro Gonzalez Alegre, Pilar Gonzalez Cabo, Rosa Ana González Polo, Ing Swie Goping, Carlos Gorbea, Nikolai V. Gorbunov, Daphne R. Goring, Adrienne M. Gorman, Sharon M. Gorski, Sandro Goruppi, Shino Goto Yamada, Cecilia Gotor, Roberta A. Gottlieb, Illana Gozes, Devrim Gozuacik, Yacine Graba, Martin Graef, Giovanna E. Granato, Gary Dean Grant, Steven Grant, Giovanni Luca Gravina, Douglas R. Green, Alexander Greenhough, Michael T. Greenwood, Benedetto Grimaldi, Frédéric Gros, Charles Grose, Jean Francois Groulx, Florian Gruber, Paolo Grumati, Tilman Grune, Jun Lin Guan, Kun Liang Guan, Barbara Guerra, Carlos Guillen, Kailash Gulshan, Jan Gunst, Chuanyong Guo, Lei Guo, Ming Guo, Wenjie Guo, Xu Guang Guo, Andrea A. Gust, Åsa B. Gustafsson, Elaine Gutierrez, Maximiliano G. Gutierrez, Ho Shin Gwak, Albert Haas, James E. Haber, Shinji Hadano, Monica Hagedorn, David R. Hahn, Andrew J. Halayko, Anne Hamacher Brady, Kozo Hamada, Ahmed Hamai, Andrea Hamann, Maho Hamasaki, Isabelle Hamer, Qutayba Hamid, Ester M. Hammond, Feng Han, Weidong Han, James T. Handa, John A. Hanover, Malene Hansen, Masaru Harada, Ljubica Harhaji Trajkovic, J. Wade Harper, Abdel Halim Harrath, Adrian L. Harris, James Harris, Udo Hasler, Peter Hasselblatt, Kazuhisa Hasui, Robert G. Hawley, Teresa S. Hawley, Congcong He, Cynthia Y. He, Fengtian He, Gu He, Rong Rong He, Xian Hui He, You Wen He, Yu Ying He, Joan K. Heath, Marie Josée Hébert, Robert A. Heinzen, Gudmundur Vignir Helgason, Michael Hensel, Elizabeth P. Henske, Chengtao Her, Paul K. Herman, Agustín Hernández, Carlos Hernandez, Sonia Hernández Tiedra, Claudio Hetz, P. Robin Hiesinger, Katsumi Higaki, Sabine Hilfiker, Bradford G. Hill, Joseph A. Hill, William D. Hill, Keisuke Hino, Daniel Hofius, Paul Hofman, Günter U. Höglinger, Jörg Höhfeld, Marina K. Holz, Yonggeun Hong, David A. Hood, Jeroen JM Hoozemans, Thorsten Hoppe, Chin Hsu, Chin Yuan Hsu, Li Chung Hsu, Dong Hu, Guochang Hu, Hong Ming Hu, Hongbo Hu, Ming Chang Hu, Yu Chen Hu, Zhuo Wei Hu, Fang Hua, Ya Hua, Canhua Huang, Huey Lan Huang, Kuo How Huang, Kuo Yang Huang, Shile Huang, Shiqian Huang, Wei Pang Huang, Yi Ran Huang, Yong Huang, Yunfei Huang, Tobias B. Huber, Patricia Huebbe, Won Ki Huh, Juha J. Hulmi, Gang Min Hur, James H. Hurley, Zvenyslava Husak, Sabah NA Hussain, Salik Hussain, Jung Jin Hwang, Seungmin Hwang, Thomas IS Hwang, Atsuhiro Ichihara, Yuzuru Imai, Carol Imbriano, Megumi Inomata, Takeshi Into, Valentina Iovane, Juan L. Iovanna, Renato V. Iozzo, Nancy Y. Ip, Javier E. Irazoqui, Pablo Iribarren, Yoshitaka Isaka, Aleksandra J. Isakovic, Harry Ischiropoulos, Jeffrey S. Isenberg, Mohammad Ishaq, Hiroyuki Ishida, Isao Ishii, Jane E. Ishmael, Ciro Isidoro, Ken ichi Isobe, Erika Isono, Shohreh Issazadeh Navikas, Koji Itahana, Eisuke Itakura, Andrei I. Ivanov, Anand Krishnan V. Iyer, José M. Izquierdo, Yotaro Izumi, Valentina Izzo, Marja Jäättelä, Nadia Jaber, Daniel John Jackson, William T. Jackson, Tony George Jacob, Thomas S. Jacques, Chinnaswamy Jagannath, Ashish Jain, Nihar Ranjan Jana, Byoung Kuk Jang, Alkesh Jani, Bassam Janji, Paulo Roberto Jannig, Patric J. Jansson, Steve Jean, Marina Jendrach, Ju Hong Jeon, Niels Jessen, Eui Bae Jeung, Kailiang Jia, Lijun Jia, Hong Jiang, Hongchi Jiang, Liwen Jiang, Teng Jiang, Xiaoyan Jiang, Xuejun Jiang, Ying Jiang, Yongjun Jiang, Alberto Jiménez, Cheng Jin, Hongchuan Jin, Lei Jin, Meiyan Jin, Shengkan Jin, Umesh Kumar Jinwal, Eun Kyeong Jo, Terje Johansen, Daniel E. Johnson, Gail VW Johnson, James D. Johnson, Eric Jonasch, Chris Jones, Leo AB Joosten, Joaquin Jordan, Anna Maria Joseph, Bertrand Joseph, Annie M. Joubert, Dianwen Ju, Jingfang Ju, Hsueh Fen Juan, Katrin Juenemann, Gábor Juhász, Hye Seung Jung, Jae U. Jung, Yong Keun Jung, Heinz Jungbluth, Matthew J. Justice, Barry Jutten, Nadeem O. Kaakoush, Kai Kaarniranta, Allen Kaasik, Tomohiro Kabuta, Bertrand Kaeffer, Katarina Kågedal, Alon Kahana, Shingo Kajimura, Or Kakhlon, Manjula Kalia, Dhan V. Kalvakolanu, Yoshiaki Kamada, Konstantinos Kambas, Vitaliy O. Kaminskyy, Harm H. Kampinga, Mustapha Kandouz, Chanhee Kang, Rui Kang, Tae Cheon Kang, Tomotake Kanki, Thirumala Devi Kanneganti, Haruo Kanno, Anumantha G. Kanthasamy, Marc Kantorow, Maria Kaparakis Liaskos, Orsolya Kapuy, Vassiliki Karantza, Md Razaul Karim, Parimal Karmakar, Arthur Kaser, Susmita Kaushik, Thomas Kawula, A. Murat Kaynar, Po Yuan Ke, Zun Ji Ke, John H. Kehrl, Kate E. Keller, Jongsook Kim Kemper, Anne K. Kenworthy, Oliver Kepp, Andreas Kern, Santosh Kesari, David Kessel, Robin Ketteler, Isis do Carmo Kettelhut, Bilon Khambu, Muzamil Majid Khan, Vinoth KM Khandelwal, Sangeeta Khare, Juliann G. Kiang, Amy A. Kiger, Akio Kihara, Arianna L. Kim, Cheol Hyeon Kim, Deok Ryong Kim, Do Hyung Kim, Eung Kweon Kim, Hye Young Kim, Hyung Ryong Kim, Jae Sung Kim, Jeong Hun Kim, Jin Cheon Kim, Jin Hyoung Kim, Kwang Woon Kim, Michael D. Kim, Moon Moo Kim, Peter K. Kim, Seong Who Kim, Soo Youl Kim, Yong Sun Kim, Yonghyun Kim, Adi Kimchi, Alec C. Kimmelman, Tomonori Kimura, Jason S. King, Karla Kirkegaard, Vladimir Kirkin, Lorrie A. Kirshenbaum, Shuji Kishi, Yasuo Kitajima, Katsuhiko Kitamoto, Yasushi Kitaoka, Kaio Kitazato, Rudolf A. Kley, Walter T. Klimecki, Michael Klinkenberg, Jochen Klucken, Helene Knævelsrud, Erwin Knecht, Laura Knuppertz, Jiunn Liang Ko, Satoru Kobayashi, Jan C. Koch, Christelle Koechlin Ramonatxo, Ulrich Koenig, Young Ho Koh, Katja Köhler, Sepp D. Kohlwein, Masato Koike, Masaaki Komatsu, Eiki Kominami, Dexin Kong, Hee Jeong Kong, Eumorphia G. Konstantakou, Benjamin T. Kopp, Tamas Korcsmaros, Laura Korhonen, Viktor I. Korolchuk, Nadya V. Koshkina, Yanjun Kou, Michael I. Koukourakis, Constantinos Koumenis, Attila L. Kovács, Tibor Kovács, Werner J. Kovacs, Daisuke Koya, Claudine Kraft, Dimitri Krainc, Helmut Kramer, Tamara Kravic Stevovic, Wilhelm Krek, Carole Kretz Remy, Roswitha Krick, Malathi Krishnamurthy, Janos Kriston Vizi, Guido Kroemer, Michael C. Kruer, Rejko Kruger, Nicholas T. Ktistakis, Kazuyuki Kuchitsu, Christian Kuhn, Addanki Pratap Kumar, Anuj Kumar, Ashok Kumar, Deepak Kumar, Dhiraj Kumar, Rakesh Kumar, Sharad Kumar, Mondira Kundu, Hsing Jien Kung, Atsushi Kuno, Sheng Han Kuo, Jeff Kuret, Tino Kurz, Terry Kwok, Taeg Kyu Kwon, Yong Tae Kwon, Irene Kyrmizi, Albert R. La Spada, Frank Lafont, Tim Lahm, Aparna Lakkaraju, Truong Lam, Trond Lamark, Steve Lancel, Terry H. Landowski, Darius JR Lane, Jon D. Lane, Cinzia Lanzi, Pierre Lapaquette, Louis R. Lapierre, Jocelyn Laporte, Johanna Laukkarinen, Gordon W. Laurie, Sergio Lavandero, Lena Lavie, Matthew J. LaVoie, Betty Yuen Kwan Law, Helen Ka wai Law, Kelsey B. Law, Robert Layfield, Pedro A. Lazo, Laurent Le Cam, Karine G. Le Roch, Hervé Le Stunff, Vijittra Leardkamolkarn, Marc Lecuit, Byung Hoon Lee, Che Hsin Lee, Erinna F. Lee, Gyun Min Lee, He Jin Lee, Hsinyu Lee, Jae Keun Lee, Jongdae Lee, Juhyun Lee, Jun Hee Lee, Michael Lee, Myung Shik Lee, Patty J. Lee, Sam W. Lee, Seung Jae Lee, Shiow Ju Lee, Stella Y. Lee, Sug Hyung Lee, Sung Sik Lee, Sung Joon Lee, Sunhee Lee, Ying Ray Lee, Yong J. Lee, Young H. Lee, Christiaan Leeuwenburgh, Sylvain Lefort, Renaud Legouis, Jinzhi Lei, Qun Ying Lei, David A. Leib, Gil Leibowitz, Istvan Lekli, Stéphane D. Lemaire, John J. Lemasters, Marius K. Lemberg, Antoinette Lemoine, Shuilong Leng, Guido Lenz, Paola Lenzi, Lilach O. Lerman, Daniele Lettieri Barbato, Julia I. Ju Leu, Hing Y. Leung, Beth Levine, Patrick A. Lewis, Frank Lezoualc'h, Chi Li, Faqiang Li, Feng Jun Li, Jun Li, Ke Li, Lian Li, Min Li, Qiang Li, Rui Li, Sheng Li, Wei Li, Xiaotao Li, Yumin Li, Jiqin Lian, Chengyu Liang, Qiangrong Liang, Yulin Liao, Joana Liberal, Pawel P. Liberski, Pearl Lie, Andrew P. Lieberman, Hyunjung Jade Lim, Kah Leong Lim, Kyu Lim, Raquel T. Lima, Chang Shen Lin, Chiou Feng Lin, Fang Lin, Fangming Lin, Fu Cheng Lin, Kui Lin, Kwang Huei Lin, Pei Hui Lin, Tianwei Lin, Wan Wan Lin, Yee Shin Lin, Yong Lin, Rafael Linden, Dan Lindholm, Lisa M. Lindqvist, Paul Lingor, Andreas Linkermann, Lance A. Liotta, Marta M. Lipinski, Vitor A. Lira, Michael P. Lisanti, Paloma B. Liton, Bo Liu, Chong Liu, Chun Feng Liu, Fei Liu, Hung Jen Liu, Jianxun Liu, Jing Jing Liu, Jing Lan Liu, Ke Liu, Leyuan Liu, Liang Liu, Quentin Liu, Rong Yu Liu, Shiming Liu, Shuwen Liu, Wei Liu, Xian De Liu, Xiangguo Liu, Xiao Hong Liu, Xinfeng Liu, Xu Liu, Xueqin Liu, Yang Liu, Yule Liu, Zexian Liu, Zhe Liu, Juan P. Liuzzi, Gérard Lizard, Mila Ljujic, Irfan J. Lodhi, Susan E. Logue, Bal L. Lokeshwar, Yun Chau Long, Sagar Lonial, Benjamin Loos, Carlos López Otín, Cristina López Vicario, Mar Lorente, Philip L. Lorenzi, Péter Lõrincz, Marek Los, Michael T. Lotze, Penny E. Lovat, Binfeng Lu, Bo Lu, Jiahong Lu, Qing Lu, She Min Lu, Shuyan Lu, Yingying Lu, Frédéric Luciano, Shirley Luckhart, John Milton Lucocq, Paula Ludovico, Aurelia Lugea, Nicholas W. Lukacs, Julian J. Lum, Anders H. Lund, Honglin Luo, Jia Luo, Shouqing Luo, Claudio Luparello, Timothy Lyons, Jianjie Ma, Yi Ma, Yong Ma, Zhenyi Ma, Juliano Machado, Glaucia M. Machado Santelli, Fernando Macian, Gustavo C. MacIntosh, Jeffrey P. MacKeigan, Kay F. Macleod, John D. MacMicking, Lee Ann MacMillan Crow, Frank Madeo, Muniswamy Madesh, Julio Madrigal Matute, Akiko Maeda, Tatsuya Maeda, Gustavo Maegawa, Emilia Maellaro, Hannelore Maes, Marta Magariños, Kenneth Maiese, Tapas K. Maiti, Luigi Maiuri, Maria Chiara Maiuri, Carl G. Maki, Roland Malli, Walter Malorni, Alina Maloyan, Fathia Mami Chouaib, Na Man, Joseph D. Mancias, Eva Maria Mandelkow, Michael A. Mandell, Angelo A. Manfredi, Serge N. Manié, Claudia Manzoni, Kai Mao, Zixu Mao, Zong Wan Mao, Philippe Marambaud, Anna Maria Marconi, Zvonimir Marelja, Gabriella Marfe, Marta Margeta, Eva Margittai, Muriel Mari, Francesca V. Mariani, Concepcio Marin, Sara Marinelli, Guillermo Mariño, Ivanka Markovic, Rebecca Marquez, MARTELLI, ALBERTO MARIA, Sascha Martens, Katie R. Martin, Seamus J. Martin, Shaun Martin, Miguel A. Martin Acebes, Paloma Martín Sanz, Camille Martinand Mari, Wim Martinet, Jennifer Martinez, Nuria Martinez Lopez, Ubaldo Martinez Outschoorn, Moisés Martínez Velázquez, Marta Martinez Vicente, Waleska Kerllen Martins, Hirosato Mashima, James A. Mastrianni, Giuseppe Matarese, Paola Matarrese, Roberto Mateo, Satoaki Matoba, Naomichi Matsumoto, Takehiko Matsushita, Akira Matsuura, Takeshi Matsuzawa, Mark P. Mattson, Soledad Matus, Norma Maugeri, Caroline Mauvezin, Andreas Mayer, Dusica Maysinger, Guillermo D. Mazzolini, Mary Kate McBrayer, Kimberly McCall, Craig McCormick, Gerald M. McInerney, Skye C. McIver, Sharon McKenna, John J. McMahon, Iain A. McNeish, Fatima Mechta Grigoriou, Jan Paul Medema, Diego L. Medina, Klara Megyeri, Maryam Mehrpour, Jawahar L. Mehta, Yide Mei, Ute Christiane Meier, Alfred J. Meijer, Alicia Meléndez, Gerry Melino, Sonia Melino, Edesio Jose Tenorio de Melo, Maria A. Mena, Marc D. Meneghini, Javier A. Menendez, Regina Menezes, Liesu Meng, Ling hua Meng, Songshu Meng, Rossella Menghini, A. Sue Menko, Rubem FS Menna Barreto, Manoj B. Menon, Marco A. Meraz Ríos, Giuseppe Merla, Luciano Merlini, Angelica M. Merlot, Andreas Meryk, Stefania Meschini, Joel N. Meyer, Man tian Mi, Chao Yu Miao, Lucia Micale, Simon Michaeli, Carine Michiels, FRANCO MIGLIACCIO, ANNA RITA, Anastasia Susie Mihailidou, Dalibor Mijaljica, Katsuhiko Mikoshiba, Enrico Milan, Leonor Miller Fleming, Gordon B. Mills, Ian G. Mills, Georgia Minakaki, Berge A. Minassian, Xiu Fen Ming, Farida Minibayeva, Elena A. Minina, Justine D. Mintern, Saverio Minucci, Antonio Miranda Vizuete, Claire H. Mitchell, Shigeki Miyamoto, Keisuke Miyazawa, Noboru Mizushima, Katarzyna Mnich, Baharia Mograbi, Simin Mohseni, Luis Ferreira Moita, Marco Molinari, Maurizio Molinari, Andreas Buch Møller, Bertrand Mollereau, Faustino Mollinedo, Marco Mongillo, Martha M. Monick, Serena Montagnaro, Craig Montell, Darren J. Moore, Michael N. Moore, Rodrigo Mora Rodriguez, Paula I. Moreira, Etienne Morel, Maria Beatrice Morelli, Sandra Moreno, Michael J. Morgan, Arnaud Moris, Yuji Moriyasu, Janna L. Morrison, Lynda A. Morrison, Eugenia Morselli, Jorge Moscat, Pope L. Moseley, Serge Mostowy, Elisa Motori, Denis Mottet, Jeremy C. Mottram, Charbel E. H. Moussa, Vassiliki E. Mpakou, Hasan Mukhtar, Jean M. Mulcahy Levy, Sylviane Muller, Raquel Muñoz Moreno, Cristina Muñoz Pinedo, Christian Münz, Maureen E. Murphy, James T. Murray, Aditya Murthy, Indira U. Mysorekar, Ivan R. Nabi, Massimo Nabissi, Gustavo A. Nader, Yukitoshi Nagahara, Yoshitaka Nagai, Kazuhiro Nagata, Anika Nagelkerke, Péter Nagy, Samisubbu R. Naidu, Sreejayan Nair, Hiroyasu Nakano, Hitoshi Nakatogawa, Meera Nanjundan, Gennaro Napolitano, Naweed I. Naqvi, Roberta Nardacci, Derek P. Narendra, Masashi Narita, Anna Chiara Nascimbeni, Ramesh Natarajan, Luiz C. Navegantes, Steffan T. Nawrocki, Taras Y. Nazarko, Volodymyr Y. Nazarko, Thomas Neill, Luca M. Neri, Mihai G. Netea, Romana T. Netea Maier, Bruno M. Neves, Paul A. Ney, Ioannis P. Nezis, Hang TT Nguyen, Huu Phuc Nguyen, Anne Sophie Nicot, Hilde Nilsen, Per Nilsson, Mikio Nishimura, Ichizo Nishino, Mireia Niso Santano, Hua Niu, Ralph A. Nixon, Vincent CO Njar, Takeshi Noda, Angelika A. Noegel, Elsie Magdalena Nolte, Erik Norberg, Koenraad K. Norga, Sakineh Kazemi Noureini, Shoji Notomi, Lucia Notterpek, Karin Nowikovsky, Nobuyuki Nukina, Thorsten Nürnberger, Valerie B. O'Donnell, Tracey O'Donovan, Peter J. O'Dwyer, Ina Oehme, Clara L. Oeste, Michinaga Ogawa, Besim Ogretmen, Yuji Ogura, Young J. Oh, Masaki Ohmuraya, Takayuki Ohshima, Rani Ojha, Koji Okamoto, Toshiro Okazaki, F. Javier Oliver, Karin Ollinger, Stefan Olsson, Daniel P. Orban, Paulina Ordonez, Idil Orhon, Laszlo Orosz, Eyleen J. O'Rourke, Helena Orozco, Angel L. Ortega, Elena Ortona, Laura D. Osellame, Junko Oshima, Shigeru Oshima, Heinz D. Osiewacz, Takanobu Otomo, Kinya Otsu, Jing hsiung James Ou, Tiago F. Outeiro, Dong yun Ouyang, Hongjiao Ouyang, Michael Overholtzer, Michelle A. Ozbun, P. Hande Ozdinler, Bulent Ozpolat, Consiglia Pacelli, Paolo Paganetti, Guylène Page, Gilles Pages, Ugo Pagnini, Beata Pajak, Stephen C. Pak, Karolina Pakos Zebrucka, Nazzy Pakpour, Zdena Palková, Francesca Palladino, Kathrin Pallauf, Nicolas Pallet, Marta Palmieri, Søren R. Paludan, Camilla Palumbo, Silvia Palumbo, Olatz Pampliega, Hongming Pan, Wei Pan, Theocharis Panaretakis, Aseem Pandey, Areti Pantazopoulou, Zuzana Papackova, Daniela L. 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Voth, Valérie Vouret Craviari, Kristina Vuori, Jatin M. Vyas, Christian Waeber, Cheryl Lyn Walker, Mark J. Walker, Jochen Walter, Lei Wan, Xiangbo Wan, Bo Wang, Caihong Wang, Chao Yung Wang, Chengshu Wang, Chenran Wang, Chuangui Wang, Dong Wang, Fen Wang, Fuxin Wang, Guanghui Wang, Hai jie Wang, Haichao Wang, Hong Gang Wang, Hongmin Wang, Horng Dar Wang, Jing Wang, Junjun Wang, Mei Wang, Mei Qing Wang, Pei Yu Wang, Peng Wang, Richard C. Wang, Shuo Wang, Ting Fang Wang, Xian Wang, Xiao jia Wang, Xiao Wei Wang, Xin Wang, Xuejun Wang, Yan Wang, Yanming Wang, Ying Wang, Ying Jan Wang, Yipeng Wang, Yu Wang, Yu Tian Wang, Yuqing Wang, Zhi Nong Wang, Pablo Wappner, Carl Ward, Diane McVey Ward, Gary Warnes, Hirotaka Watada, Yoshihisa Watanabe, Kei Watase, Timothy E. Full Terms, Conditions of access, use can be found at h.t.t.p.:././.w.w.w. t.a.n.d.f.o.n.l.i.n.e. com/action/journalInformation?journalCode=kaup20 Download by: [Alma Mater Studiorum Università di Bologna] Date: 23 September 2016, At: 06:43 Weaver, Colin D. Weekes, Jiwu Wei, Thomas Weide, Conrad C. Weihl, Günther Weindl, Simone Nardin Weis, Longping Wen, Xin Wen, Yunfei Wen, Benedikt Westermann, Cornelia M. Weyand, Anthony R. White, Eileen White, J. Lindsay Whitton, Alexander J. Whitworth, Joëlle Wiels, Franziska Wild, Manon E. Wildenberg, Tom Wileman, Deepti Srinivas Wilkinson, Simon Wilkinson, Dieter Willbold, Chris Williams, Katherine Williams, Peter R. Williamson, Konstanze F. Winklhofer, Steven S. Witkin, Stephanie E. Wohlgemuth, Thomas Wollert, Ernst J. Wolvetang, Esther Wong, G. William Wong, Richard W. Wong, Vincent Kam Wai Wong, Elizabeth A. Woodcock, Karen L. Wright, Chunlai Wu, Defeng Wu, Gen Sheng Wu, Jian Wu, Junfang Wu, Mian Wu, Min Wu, Shengzhou Wu, William KK Wu, Yaohua Wu, Zhenlong Wu, Cristina PR Xavier, Ramnik J. Xavier, Gui Xian Xia, Tian Xia, Weiliang Xia, Yong Xia, Hengyi Xiao, Jian Xiao, Shi Xiao, Wuhan Xiao, Chuan Ming Xie, Zhiping Xie, Zhonglin Xie, Maria Xilouri, Yuyan Xiong, Chuanshan Xu, Congfeng Xu, Feng Xu, Haoxing Xu, Hongwei Xu, Jian Xu, Jianzhen Xu, Jinxian Xu, Liang Xu, Xiaolei Xu, Yangqing Xu, Ye Xu, Zhi Xiang Xu, Ziheng Xu, Yu Xue, Takahiro Yamada, Ai Yamamoto, Koji Yamanaka, Shunhei Yamashina, Shigeko Yamashiro, Bing Yan, Bo Yan, Xianghua Yan, Zhen Yan, Yasuo Yanagi, Dun Sheng Yang, Jin Ming Yang, Liu Yang, Minghua Yang, Pei Ming Yang, Peixin Yang, Qian Yang, Wannian Yang, Wei Yuan Yang, Xuesong Yang, Yi Yang, Ying Yang, Zhifen Yang, Zhihong Yang, Meng Chao Yao, Pamela J. Yao, Xiaofeng Yao, Zhenyu Yao, Zhiyuan Yao, Linda S. Yasui, Mingxiang Ye, Barry Yedvobnick, Behzad Yeganeh, Elizabeth S. Yeh, Patricia L. Yeyati, Fan Yi, Long Yi, Xiao Ming Yin, Calvin K. Yip, Yeong Min Yoo, Young Hyun Yoo, Seung Yong Yoon, Ken Ichi Yoshida, Tamotsu Yoshimori, Ken H. Young, Huixin Yu, Jane J. Yu, Jin Tai Yu, Jun Yu, Li Yu, W. Haung Yu, Xiao Fang Yu, Zhengping Yu, Junying Yuan, Zhi Min Yuan, Beatrice YJT Yue, Jianbo Yue, Zhenyu Yue, David N. Zacks, Eldad Zacksenhaus, Nadia Zaffaroni, Tania Zaglia, Zahra Zakeri, Vincent Zecchini, Jinsheng Zeng, Min Zeng, Qi Zeng, Antonis S. Zervos, Donna D. Zhang, Fan Zhang, Guo Zhang, Guo Chang Zhang, Hao Zhang, Hong Zhang, Hongbing Zhang, Jian Zhang, Jiangwei Zhang, Jianhua Zhang, Jing pu Zhang, Li Zhang, Lin Zhang, Long Zhang, Ming Yong Zhang, Xiangnan Zhang, Xu Dong Zhang, Yan Zhang, Yang Zhang, Yanjin Zhang, Yingmei Zhang, Yunjiao Zhang, Mei Zhao, Wei Li Zhao, Xiaonan Zhao, Yan G. Zhao, Ying Zhao, Yongchao Zhao, Yu xia Zhao, Zhendong Zhao, Zhizhuang J. Zhao, Dexian Zheng, Xi Long Zheng, Xiaoxiang Zheng, Boris Zhivotovsky, Qing Zhong, Guang Zhou Zhou, Guofei Zhou, Huiping Zhou, Shu Feng Zhou, Xu jie Zhou, Hongxin Zhu, Hua Zhu, Wei Guo Zhu, Wenhua Zhu, Xiao Feng Zhu, Yuhua Zhu, Shi Mei Zhuang, Xiaohong Zhuang, Elio Ziparo, Christos E. Zois, Teresa Zoladek, Wei Xing Zong, Antonio Zorzano, Susu M. Zughaier, Life Sciences Institute and Department of Molecular, Cellular, and Developmental Biology and Biological Chemistry, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Tokyo Medical University, The Hebrew University of Jerusalem (HUJ), Mammalian Genetics Unit, Medical Research Council Harwell, University of Occupational and Environmental Health School of Medicine, Partenaires INRAE, University of Toronto, Ben-Gurion University of the Negev (BGU), University of Colorado [Boulder], Cell Death Research & Therapy (CDRT) Lab, Université Catholique de Louvain = Catholic University of Louvain (UCL), University of Vienna [Vienna], Conway Institute of Biomolecular and Biomedical Research and School of Chemical and Bioprocess Engineering, University College Dublin [Dublin] (UCD), Georgetown University, Candiolo Cancer Institute (IRCCS), Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III [Madrid] (ISC), Ikerbasque - Basque Foundation for Science, Cleveland Clinic, Sidney Kimmel Cancer Center, Jefferson (Philadelphia University + Thomas Jefferson University), Universidad de Buenos Aires (UBA), Department of Clinical Neurosciences, University College of London [London] (UCL)-Institute of Neurology, Thérapie génique, Génomique et Epigénomique (U 1169), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Consiglio Nazionale delle Ricerche (CNR), Osaka University, Department of Experimental Medicine and Public Health, University of Camerino, University of Barcelona, Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7), Génomique Fonctionnelle des Tumeurs Solides (U1162), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5), Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Physics, Technical University of Denmark [Lyngby] (DTU), University of Zaragoza - Universidad de Zaragoza [Zaragoza], Department of Pharmaco-Biology, Università della Calabria [Arcavacata di Rende] (Unical), Fondation Universitaire Notre Dame de la Paix (FUNDP), Facultés Universitaires Notre Dame de la Paix (FUNDP), USC Neuromuscular Center, Department of Neurology, University of Southern California (USC), Physiopathologie de la survie et de la mort cellulaire et infection virale, Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Giannina Gaslini Institute, Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226, Inner Mongolia Agricultural University (IMAU), Politecnico di Milano [Milan] (POLIMI), Department of Civil, Geological, and Mining Engineering, École Polytechnique de Montréal (EPM)-NSERC Industrial Chair on Drinking Water, Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Department of Molecular Medicine, Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Physiopathologie du système nerveux central - Institut François Magendie, Université Bordeaux Segalen - Bordeaux 2-IFR8-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratory of Experimental Virology - Department of Medical Microbiology [Amsterdam, The Netherlands], Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA)-University of Amsterdam [Amsterdam] (UvA)-Center for Infection and Immunity Amsterdam - CINIMA [Amsterdam, The Netherlands], Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Dynamique des interactions membranaires normales et pathologiques (DIMNP), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Montpellier 1 (UM1), Department of Internal Medicine, Hospital Universitario Infanta Sofía, Celullar and Molecular Medicine, Infection bactérienne, inflammation, et carcinogenèse digestive, University of Edinburgh, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Faculty of Engineering and Natural Sciences, Sabanci University [Istanbul], University of Science and Technology Beijing [Beijing] (USTB), Centre for Computational and Systems Biology (COSBI), Sun Yat-Sen University [Guangzhou] (SYSU), Dynamique Musculaire et Métabolisme (DMEM), Université de Montpellier (UM)-Institut National de la Recherche Agronomique (INRA), CAS Institute of Oceanology (IOCAS), Chinese Academy of Sciences [Beijing] (CAS), Polytechnic University of Marche, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Cell Biology, Physiology and Immunology, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Pisa - Università di Pisa, Dulbecco Telethon Institute/Department of Biology, Fondation de Recherche Cancer et Sang - Hôpital Kirchberg, China University of Petroleum, Unilever R&D, University of Queensland [Brisbane], University of Minnesota [Twin Cities] (UMN), University of Minnesota System, Laboratoire de Génie des Procédés et Matériaux - EA 4038 (LGPM), CentraleSupélec, Institute for Advanced Study [Tsinghua], Tsinghua University [Beijing] (THU), Nanayang Technological University (NTU), Nanayang Technological University, Institute of Microelectronics [Beijing] (IMETU), Laboratoire de photonique et de nanostructures (LPN), Centre National de la Recherche Scientifique (CNRS), Institut de biologie moléculaire des plantes (IBMP), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Northwestern Polytechnical University [Xi'an] (NPU), University of Pennsylvania [Philadelphia], City University of Hong Kong (CityU), Department of Mathematics [Berkeley], University of California [Berkeley], University of California-University of California, ZJU-ENS Joint Laboratory of Medicinal Chemistry, Zhejiang University, University of Cincinnati (UC), Réponses immunes : régulation et développement, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), The University of New Mexico [Albuquerque], Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Scienze Biomediche, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Department of Experimental Medicine and Oncology, University of Turin, Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), CNV, University of Valparaiso, Université Paris 1 Panthéon-Sorbonne - UFR d'Arts plastiques et sciences de l'art (UP1 UFR04), Université Paris 1 Panthéon-Sorbonne (UP1), Department of General, Visceral and Vascular Surgery [Jena], Friedrich-Schiller-Universität Jena, Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 (RNMCD), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM), Réseau International des Instituts Pasteur (RIIP), Macrophages et Développement de l’Immunité, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Immunobiologie des Cellules Dendritiques, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'infectiologie Necker-Pasteur [CHU Necker], Institut Pasteur [Paris]-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Pasteur [Paris], Trafic membranaire et Division cellulaire - Membrane Traffic and Cell Division, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Cibles thérapeutiques, formulation et expertise pré-clinique du médicament (CITHEFOR), Université de Lorraine (UL), This work was supported in part by the National Institutes of Health, including Public Health Service grant GM053396 to D.J.K. Due to space and other limitations, it is not possible to include all other sources of financial support., In a rapidly expanding and highly dynamic field such as autophagy, it is possible that some authors who should have been included on this article have been missed. D.J.K. extends his apologies to researchers in the field of autophagy who, due to oversight or any other reason, could not be included on this article. I also note that two of our colleagues on this manuscript have passed away: Arlette Darfeuille-Michaud and Wouter van Doorn., Life Sciences Institute [Ann Arbor, MI, USA], Laboratoire de Biogenèse Membranaire, CNRS UMR 5200, Université de Bordeaux, INRA Bordeaux Aquitaine, Villenave d'Ornon, France., Amelio, Ivano [0000-0002-9126-5391], Beale, Rupert [0000-0002-6705-8560], Floto, Andres [0000-0002-2188-5659], Frezza, Christian [0000-0002-3293-7397], Ktistakis, Nicholas [0000-0001-9397-2914], Melino, Gerry [0000-0001-9428-5972], Narita, Masashi [0000-0001-7764-577X], Rubinsztein, David [0000-0001-5002-5263], Underwood, Benjamin [0000-0003-3427-9487], Whitworth, Alex [0000-0002-1154-6629], Apollo - University of Cambridge Repository, Université Catholique de Louvain, Facultés Universitaires Notre-Dame de la Paix, Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR50-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Nice Sophia Antipolis (... - 2019) (UNS), Department of Clinical and Molecular Medicine, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' [Rome], Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Sun Yat-Sen University (SYSU), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), University of Minnesota [Twin Cities], Tsinghua University [Beijing], Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Panthéon-Sorbonne - UFR d'Arts plastiques et sciences de l'art (UP1 UFR04), Université Panthéon-Sorbonne (UP1), Récepteurs nucléaires, maladies cardiovasculaires et diabète (EGID), Université de Lille, Droit et Santé-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Necker - Enfants Malades [AP-HP], Trafic membranaire et Division cellulaire, Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Collège de France (CdF)-Centre National de la Recherche Scientifique (CNRS), Klionsky, D., Abdelmohsen, K., Abe, A., Abedin, M., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C., Adams, P., Adeli, K., Adhihetty, P., Adler, S., Agam, G., Agarwal, R., Aghi, M., Agnello, M., Agostinis, P., Aguilar, P., Aguirre-Ghiso, J., Airoldi, E., Ait-Si-Ali, S., Akematsu, T., Akporiaye, E., Al-Rubeai, M., Albaiceta, G., Albanese, C., Albani, D., Albert, M., Aldudo, J., Algül, H., Alirezaei, M., Alloza, I., Almasan, A., Almonte-Beceril, M., Alnemri, E., Alonso, C., Altan-Bonnet, N., Altieri, D., Alvarez, S., Alvarez-Erviti, L., Alves, S., Amadoro, G., Amano, A., Amantini, C., Ambrosio, S., Amelio, I., Amer, A., Amessou, M., Amon, A., An, Z., Anania, F., Andersen, S., Andley, U., Andreadi, C., Andrieu-Abadie, N., Anel, A., Ann, D., Anoopkumar-Dukie, S., Antonioli, M., Aoki, H., Apostolova, N., Aquila, S., Aquilano, K., Araki, K., Arama, E., Aranda, A., Araya, J., Arcaro, A., Arias, E., Arimoto, H., Ariosa, A., Armstrong, J., Arnould, T., Arsov, I., Asanuma, K., Askanas, V., Asselin, E., Atarashi, R., Atherton, S., Atkin, J., Attardi, L., Auberger, P., Auburger, G., Aurelian, L., Autelli, R., Avagliano, L., Avantaggiati, M., Avrahami, L., Awale, S., Azad, N., Bachetti, T., Backer, J., Bae, D., Bae, J., Bae, O., Bae, S., Baehrecke, E., Baek, S., Baghdiguian, S., Bagniewska-Zadworna, A., Bai, H., Bai, J., Bai, X., Bailly, Y., Balaji, K., Balduini, W., Ballabio, A., Balzan, R., Banerjee, R., Bánhegyi, G., Bao, H., Barbeau, B., Barrachina, M., Barreiro, E., Bartel, B., Bartolomé, A., Bassham, D., Bassi, M., Bast, R., Basu, A., Batista, M., Batoko, H., Battino, M., Bauckman, K., Baumgarner, B., Bayer, K., Beale, R., Beaulieu, J., Beck, G., Becker, C., Beckham, J., Bédard, P., Bednarski, P., Begley, T., Behl, C., Behrends, C., Behrens, G., Behrns, K., Bejarano, E., Belaid, A., Belleudi, F., Bénard, G., Berchem, G., Bergamaschi, D., Bergami, M., Berkhout, B., Berliocchi, L., Bernard, A., Bernard, M., Bernassola, F., Bertolotti, A., Bess, A., Besteiro, S., Bettuzzi, S., Bhalla, S., Bhattacharyya, S., Bhutia, S., Biagosch, C., Bianchi, M., Biard-Piechaczyk, M., Billes, V., Bincoletto, C., Bingol, B., Bird, S., Bitoun, M., Bjedov, I., Blackstone, C., Blanc, L., Blanco, G., Blomhoff, H., Boada-Romero, E., Böckler, S., Boes, M., Boesze-Battaglia, K., Boise, L., Bolino, A., Boman, A., Bonaldo, P., Bordi, M., Bosch, J., Botana, L., Botti, J., Bou, G., Bouché, M., Bouchecareilh, M., Boucher, M., Boulton, M., Bouret, S., Boya, P., Boyer-Guittaut, M., Bozhkov, P., Brady, N., Braga, V., Brancolini, C., Braus, G., Bravo-San Pedro, J., Brennan, L., Bresnick, E., Brest, P., Bridges, D., Bringer, M., Brini, M., Brito, G., Brodin, B., Brookes, P., Brown, E., Brown, K., Broxmeyer, H., Bruhat, A., Brum, P., Brumell, J., Brunetti-Pierri, N., Bryson-Richardson, R., Buch, S., Buchan, A., Budak, H., Bulavin, D., Bultman, S., Bultynck, G., Bumbasirevic, V., Burelle, Y., Burke, R., Burmeister, M., Bütikofer, P., Caberlotto, L., Cadwell, K., Cahova, M., Cai, D., Cai, J., Cai, Q., Calatayud, S., Camougrand, N., Campanella, M., Campbell, G., Campbell, M., Campello, S., Candau, R., Caniggia, I., Cantoni, L., Cao, L., Caplan, A., Caraglia, M., Cardinali, C., Cardoso, S., Carew, J., Carleton, L., Carlin, C., Carloni, S., Carlsson, S., Carmona-Gutierrez, D., Carneiro, L., Carnevali, O., Carra, S., Carrier, A., Carroll, B., Casas, C., Casas, J., Cassinelli, G., Castets, P., Castro-Obregon, S., Cavallini, G., Ceccherini, I., Cecconi, F., Cederbaum, A., Ceña, V., Cenci, S., Cerella, C., Cervia, D., Cetrullo, S., Chaachouay, H., Chae, H., Chagin, A., Chai, C., Chakrabarti, G., Chamilos, G., Chan, E., Chan, M., 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Shieh, Jj, Shih, Cm, Shimada, Y, Shimizu, S, Shin, Dw, Shinohara, Ml, Shintani, M, Shintani, T, Shioi, T, Shirabe, K, Shiri Sverdlov, R, Shirihai, O, Shore, Gc, Shu, Cw, Shukla, D, Sibirny, Aa, Sica, V, Sigurdson, Cj, Sigurdsson, Em, Sijwali, P, Sikorska, B, Silveira, Wa, Silvente Poirot, S, Silverman, Ga, Simak, J, Simmet, T, Simon, Ak, Simon, Hu, Simone, C, Simons, M, Simonsen, A, Singh, R, Singh, Sv, Singh, Sk, Sinha, D, Sinha, S, Sinicrope, Fa, Sirko, A, Sirohi, K, Sishi, Bj, Sittler, A, Siu, Pm, Sivridis, E, Skwarska, A, Slack, R, Slaninová, I, Slavov, N, Smaili, S, Smalley, K, Smith, Dr, Soenen, Sj, Soleimanpour, Sa, Solhaug, A, Somasundaram, K, Son, Jh, Sonawane, A, Song, C, Song, F, Song, Hk, Song, Jx, Song, W, Soo, Ky, Sood, Ak, Soong, Tw, Soontornniyomkij, V, Sorice, M, Sotgia, F, Soto Pantoja, Dr, Sotthibundhu, A, Sousa, Mj, Spaink, Hp, Span, Pn, Spang, A, Sparks, Jd, Speck, Pg, Spector, Sa, Spies, Cd, Springer, W, Clair, D, Stacchiotti, A, Staels, B, Stang, Mt, 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Taylor, Ga, Taylor, Jp, Taylor, Mj, Tchetina, Ev, Tee, Ar, Teixeira Clerc, F, Telang, S, Tencomnao, T, Teng, Bb, Teng, Rj, Terro, F, Tettamanti, G, Theiss, Al, Theron, Ae, Thomas, Kj, Thomé, Mp, Thomes, Pg, Thorburn, A, Thorner, J, Thum, T, Thumm, M, Thurston, Tl, Tian, L, Till, A, Ting, Jp, Titorenko, Vi, Toker, L, Toldo, S, Tooze, Sa, Topisirovic, I, Torgersen, Ml, Torosantucci, L, Torriglia, A, Torrisi, Mr, Tournier, C, Towns, R, Trajkovic, V, Travassos, Lh, Triola, G, Tripathi, Dn, Trisciuoglio, D, Troncoso, R, Trougakos, Ip, Truttmann, Ac, Tsai, Kj, Tschan, Mp, Tseng, Yh, Tsukuba, T, Tsung, A, Tsvetkov, A, Tu, S, Tuan, Hy, Tucci, M, Tumbarello, Da, Turk, B, Turk, V, Turner, Rf, Tveita, Aa, Tyagi, Sc, Ubukata, M, Uchiyama, Y, Udelnow, A, Ueno, T, Umekawa, M, Umemiya Shirafuji, R, Underwood, Br, Ungermann, C, Ureshino, Rp, Ushioda, R, Uversky, Vn, Uzcátegui, Nl, Vaccari, T, Vaccaro, Mi, Váchová, L, Vakifahmetoglu Norberg, H, Valdor, R, Valente, Em, Vallette, F, Valverde, Am, Van den Berghe, G, Van Den Bosch, L, van den Brink, Gr, van der Goot, Fg, van der Klei, Ij, van der Laan, Lj, van Doorn, Wg, van Egmond, M, van Golen, Kl, Van Kaer, L, van Lookeren Campagne, M, Vandenabeele, P, Vandenberghe, W, Vanhorebeek, I, Varela Nieto, I, Vasconcelos, Mh, Vasko, R, Vavvas, Dg, Vega Naredo, I, Velasco, G, Velentzas, Ad, Velentzas, Pd, Vellai, T, Vellenga, E, Vendelbo, Mh, Venkatachalam, K, Ventura, N, Ventura, S, Veras, P, Verdier, M, Vertessy, Bg, Viale, A, Vidal, M, Vieira, H, Vierstra, Rd, Vigneswaran, N, Vij, N, Vila, M, Villar, M, Villar, Vh, Villarroya, J, Vindis, C, Viola, G, Viscomi, Mt, Vitale, G, Vogl, Dt, Voitsekhovskaja, Ov, von Haefen, C, von Schwarzenberg, K, Voth, De, Vouret Craviari, V, Vuori, K, Vyas, Jm, Waeber, C, Walker, Cl, Walker, Mj, Walter, J, Wan, L, Wan, X, Wang, B, Wang, C, Wang, Cy, Wang, D, Wang, F, Wang, G, Wang, Hj, Wang, H, Wang, Hg, Wang, Hd, Wang, J, Wang, M, Wang, Mq, Wang, Py, Wang, P, Wang, Rc, Wang, S, Wang, Tf, Wang, X, Wang, Xj, Wang, Xw, Wang, Y, Wang, Yj, Wang, Yt, Wang, Zn, Wappner, P, Ward, C, Ward, Dm, Warnes, G, Watada, H, Watanabe, Y, Watase, K, Weaver, Te, Weekes, Cd, Wei, J, Weide, T, Weihl, Cc, Weindl, G, Weis, Sn, Wen, L, Wen, X, Wen, Y, Westermann, B, Weyand, Cm, White, Ar, White, E, Whitton, Jl, Whitworth, Aj, Wiels, J, Wild, F, Wildenberg, Me, Wileman, T, Wilkinson, D, Wilkinson, S, Willbold, D, Williams, C, Williams, K, Williamson, Pr, Winklhofer, Kf, Witkin, S, Wohlgemuth, Se, Wollert, T, Wolvetang, Ej, Wong, E, Wong, Gw, Wong, Rw, Wong, Vk, Woodcock, Ea, Wright, Kl, Wu, C, Wu, D, Wu, G, Wu, J, Wu, M, Wu, S, Wu, Wk, Wu, Y, Wu, Z, Xavier, Cp, Xavier, Rj, Xia, Gx, Xia, T, Xia, W, Xia, Y, Xiao, H, Xiao, J, Xiao, S, Xiao, W, Xie, Cm, Xie, Z, Xilouri, M, Xiong, Y, Xu, C, Xu, F, Xu, H, Xu, J, Xu, L, Xu, X, Xu, Y, Xu, Zx, Xu, Z, Xue, Y, Yamada, T, Yamamoto, A, Yamanaka, K, Yamashina, S, Yamashiro, S, Yan, B, Yan, X, Yan, Z, Yanagi, Y, Yang, D, Yang, Jm, Yang, L, Yang, M, Yang, Pm, Yang, P, Yang, Q, Yang, W, Yang, Wy, Yang, X, Yang, Y, Yang, Z, Yao, Mc, Yao, Pj, Yao, X, Yao, Z, Yasui, L, Ye, M, Yedvobnick, B, Yeganeh, B, Yeh, E, Yeyati, Pl, Yi, F, Yi, L, Yin, Xm, Yip, Ck, Yoo, Ym, Yoo, Yh, Yoon, Sy, Yoshida, Ki, Yoshimori, T, Young, Kh, Yu, H, Yu, Jj, Yu, Jt, Yu, J, Yu, L, Yu, Wh, Yu, Xf, Yu, Z, Yuan, J, Yuan, Zm, Yue, By, Yue, J, Yue, Z, Zacks, Dn, Zacksenhaus, E, Zaffaroni, N, Zaglia, T, Zakeri, Z, Zecchini, V, Zeng, J, Zeng, M, Zeng, Q, Zervos, A, Zhang, Dd, Zhang, F, Zhang, G, Zhang, Gc, Zhang, H, Zhang, J, Zhang, Jp, Zhang, L, Zhang, My, Zhang, X, Zhang, Xd, Zhang, Y, Zhao, M, Zhao, Wl, Zhao, X, Zhao, Yg, Zhao, Y, Zhao, Yx, Zhao, Z, Zhao, Zj, Zheng, D, Zheng, Xl, Zheng, X, Zhivotovsky, B, Zhong, Q, Zhou, Gz, Zhou, G, Zhou, H, Zhou, Sf, Zhou, Xj, Zhu, H, Zhu, Wg, Zhu, W, Zhu, Xf, Zhu, Y, Zhuang, Sm, Zhuang, X, Ziparo, E, Zois, Ce, Zoladek, T, Zong, Wx, Zorzano, A, Zughaier, Sm, AII - Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention, Other departments, CCA -Cancer Center Amsterdam, Center of Experimental and Molecular Medicine, Radiotherapy, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Medical Biochemistry, ANS - Cellular & Molecular Mechanisms, Cell Biology and Histology, Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, Christopher M Adam, Peter D Adam, Khosrow Adeli, Peter J Adhihetty, Sharon G Adler, Galila Agam, Rajesh Agarwal, Manish K Aghi, Maria Agnello, Patrizia Agostini, Patricia V Aguilar, Julio Aguirre-Ghiso, Edoardo M Airoldi, Slimane Ait-Si-Ali, Takahiko Akematsu, Emmanuel T Akporiaye, Mohamed Al-Rubeai, Guillermo M Albaiceta, Chris Albanese, Diego Albani, Matthew L Albert, Jesus Aldudo, Hana Algül, Mehrdad Alirezaei, Iraide Alloza, Alexandru Almasan, Maylin Almonte-Beceril, Emad S Alnemri, Covadonga Alonso, Nihal Altan-Bonnet, Dario C Altieri, Silvia Alvarez, Lydia Alvarez- Erviti, Sandro Alve, Giuseppina Amadoro, Atsuo Amano, Consuelo Amantini, Santiago Ambrosio, Ivano Amelio, Amal O Amer, Mohamed Amessou, Angelika Amon, Zhenyi An, Frank A Anania, Stig U Andersen, Usha P Andley, Catherine K Andreadi, Nathalie Andrieu- Abadie, Alberto Anel, David K Ann, Shailendra Anoopkumar-Dukie, Manuela Antonioli, Hiroshi Aoki, Nadezda Apostolova, Saveria Aquila, Katia Aquilano, Koichi Araki, Eli Arama, Agustin Aranda, Jun Araya, Alexandre Arcaro, Esperanza Aria, Hirokazu Arimoto, Aileen R Ariosa, Jane L Armstrong, Thierry Arnould, Ivica Arsov, Katsuhiko Asanuma, Valerie Askana, Eric Asselin, Ryuichiro Atarashi, Sally S Atherton, Julie D Atkin, Laura D Attardi, Patrick Auberger, Georg Auburger, Laure Aurelian, Riccardo Autelli, Laura Avagliano, Maria Laura Avantaggiati, Limor Avrahami, Suresh Awale, Neelam Azad, Tiziana Bachetti, Jonathan M Backer, Dong- Hun Bae, Jae-sung Bae, Ok-Nam Bae, Soo Han Bae, Eric H Baehrecke, Seung-Hoon Baek, Stephen Baghdiguian, Agnieszka Bagniewska-Zadworna, Hua Bai, Jie Bai, Xue-Yuan Bai, Yannick Bailly, Kithiganahalli Narayanaswamy Balaji, Walter Balduini, Andrea Ballabio, Rena Balzan, Rajkumar Banerjee, Gábor Bánhegyi, Haijun Bao, Benoit Barbeau, Maria D Barrachina, Esther Barreiro, Bonnie Bartel, Alberto Bartolomé, Diane C Bassham, Maria Teresa Bassi, Robert C Bast Jr, Alakananda Basu, Maria Teresa Batista, Henri Batoko, Maurizio Battino, Kyle Bauckman, Bradley L Baumgarner, K Ulrich Bayer, Rupert Beale, Jean-François Beaulieu, George R. Beck Jr, Christoph Becker, J David Beckham, Pierre-André Bédard, Patrick J Bednarski, Thomas J Begley, Christian Behl, Christian Behrend, Georg MN Behren, Kevin E Behrn, Eloy Bejarano, Amine Belaid, Francesca Belleudi, Giovanni Bénard, Guy Berchem, Daniele Bergamaschi, Matteo Bergami, Ben Berkhout, Laura Berliocchi, Amélie Bernard, Monique Bernard, Francesca Bernassola, Anne Bertolotti, Amanda S Be, Sébastien Besteiro, Saverio Bettuzzi, Savita Bhalla, Shalmoli Bhattacharyya, Sujit K Bhutia, Caroline Biagosch, Michele Wolfe Bianchi, Martine Biard-Piechaczyk, Viktor Bille, Claudia Bincoletto, Baris Bingol, Sara W Bird, Marc Bitoun, Ivana Bjedov, Craig Blackstone, Lionel Blanc, Guillermo A Blanco, Heidi Kiil Blomhoff, Emilio Boada-Romero, Stefan Böckler, Marianne Boe, Kathleen Boesze-Battaglia, Lawrence H Boise, Alessandra Bolino, Andrea Boman, Paolo Bonaldo, Matteo Bordi, Jürgen Bosch, Luis M Botana, Joelle Botti, German Bou, Marina Bouché, Marion Bouchecareilh, Marie- Josée Boucher, Michael E Boulton, Sebastien G Bouret, Patricia Boya, Michaël Boyer-Guittaut, Peter V Bozhkov, Nathan Brady, Vania MM Braga, Claudio Brancolini, Gerhard H Brau, José M Bravo-San Pedro, Lisa A Brennan, Emery H Bresnick, Patrick Brest, Dave Bridge, MarieAgnès Bringer, Marisa Brini, Glauber C Brito, Bertha Brodin, Paul S Brooke, Eric J Brown, Karen Brown, Hal E Broxmeyer, Alain Bruhat, Patricia Chakur Brum, John H Brumell, Nicola Brunetti-Pierri, Robert J Bryson-Richardson, Shilpa Buch, Alastair M Buchan, Hikmet Budak, Dmitry V Bulavin, Scott J Bultman, Geert Bultynck, Vladimir Bumbasirevic, Yan Burelle, Robert E Burke, Margit Burmeister, Peter Bütikofer, Laura Caberlotto, Ken Cadwell, Monika Cahova, Dongsheng Cai, Jingjing Cai, Qian Cai, Sara Calatayud, Nadine Camougrand, Michelangelo Campanella, Grant R Campbell, Matthew Campbell, Silvia Campello, Robin Candau, Isabella Caniggia, Lavinia Cantoni, Lizhi Cao, Allan B Caplan, Michele Caraglia, Claudio Cardinali, Sandra Morais Cardoso, Jennifer S Carew, Laura A Carleton, Cathleen R Carlin, Silvia Carloni, Sven R Carlsson, Didac Carmona-Gutierrez, Leticia AM Carneiro, Oliana Carnevali, Serena Carra, Alice Carrier, Bernadette Carroll, Caty Casa, Josefina Casa, Giuliana Cassinelli, Perrine Castet, Susana Castro-Obregon, Gabriella Cavallini, Isabella Ceccherini, Francesco Cecconi, Arthur I Cederbaum, Valentín Ceña, Simone Cenci, Claudia Cerella, Davide Cervia, Silvia Cetrullo, Hassan Chaachouay, Han-Jung Chae, Andrei S Chagin, Chee-Yin Chai, Gopal Chakrabarti, Georgios Chamilo, Edmond YW Chan, Matthew TV Chan, Dhyan Chandra, Pallavi Chandra, Chih-Peng Chang, Raymond Chuen-Chung Chang, Ta Yuan Chang, John C Chatham, Saurabh Chatterjee, Santosh Chauhan, Yongsheng Che, Michael E Cheetham, Rajkumar Cheluvappa, Chun-Jung Chen, Gang Chen, Guang-Chao Chen, Guoqiang Chen, Hongzhuan Chen, Jeff W Chen, Jian-Kang Chen, Min Chen, Mingzhou Chen, Peiwen Chen, Qi Chen, Quan Chen, Shang- Der Chen, Si Chen, Steve S-L Chen, Wei Chen, 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Shrawan K Singh, Debasish Sinha, Sangita Sinha, Frank A Sinicrope, Agnieszka Sirko, Kapil Sirohi, Balindiwe JN Sishi, Annie Sittler, Parco M Siu, Efthimios Sivridi, Anna Skwarska, Ruth Slack, Iva Slaninová, Nikolai Slavov, Soraya S Smaili, Keiran SM Smalley, Duncan R Smith, Stefaan J Soenen, Scott A Soleimanpour, Anita Solhaug, Kumaravel Somasundaram, Jin H Son, Avinash Sonawane, Chunjuan Song, Fuyong Song, Hyun Kyu Song, Ju-Xian Song, Wei Song, Kai Y Soo, Anil K Sood, Tuck Wah Soong, Virawudh Soontornniyomkij, Maurizio Sorice, Federica Sotgia, David R Soto-Pantoja, Areechun Sotthibundhu, Maria João Sousa, Herman P Spaink, Paul N Span, Anne Spang, Janet D Spark, Peter G Speck, Stephen A Spector, Claudia D Spie, Wolfdieter Springer, Daret St Clair, Alessandra Stacchiotti, Bart Stael, Michael T Stang, Daniel T Starczynowski, Petro Starokadomskyy, Clemens Steegborn, John W Steele, Leonidas Stefani, Joan Steffan, Christine M Stellrecht, Harald Stenmark, Tomasz M Stepkowski, Stęphan T 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[SDV]Life Sciences [q-bio] ,autophagosome ,Review Article ,ddc:616.07 ,stress ,stre ,LC3 ,MESH: Animals ,Settore MED/49 - Scienze Tecniche Dietetiche Applicate ,Settore BIO/06 - Anatomia Comparata E Citologia ,chaperone-mediated autophagy ,ComputingMilieux_MISCELLANEOUS ,Settore BIO/11 ,Pharmacology. Therapy ,Settore BIO/13 ,standards [Biological Assay] ,autolysosome ,MESH: Autophagy*/physiology ,lysosome ,methods [Biological Assay] ,Biological Assay ,Settore BIO/17 - ISTOLOGIA ,Erratum ,Human ,Biochemistry & Molecular Biology ,Settore BIO/06 ,physiology [Autophagy] ,Chaperonemediated autophagy ,[SDV.BC]Life Sciences [q-bio]/Cellular Biology ,NO ,autophagy, guidelines, molecular biology, ultrastructure ,flux ,macroautophagy ,phagophore ,vacuole ,MESH: Biological Assay/methods ,MESH: Computer Simulation ,ddc:570 ,Autolysosome, Autophagosome, Chaperonemediated autophagy, Flux, LC3, Lysosome, Macroautophagy, Phagophore, Stress, Vacuole ,Autophagy ,Animals ,Humans ,Computer Simulation ,Settore BIO/10 ,ddc:612 ,Biology ,MESH: Humans ,Animal ,0601 Biochemistry And Cell Biology ,MESH: Biological Assay/standards ,Human medicine - Abstract
Seuls les 100 premiers auteurs dont les auteurs INRA ont été entrés dans la notice. La liste complète des auteurs et de leurs affiliations est accessible sur la publication.; International audience; In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes.For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure flux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy.Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation, it is imperative to target by gene knockout or RNA interference more than one autophagy-related protein. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways implying that not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular assays, we hope to encourage technical innovation in the field.
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39. Prediction of worsening of skin fibrosis in patients with diffuse cutaneous systemic sclerosis using the EUSTAR database
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Maurer, B., Graf, N., Michel, B. A., Muller Ladner, U., Czirjak, L., Denton, C. P., Tyndall, A., Metzig, C., Lanius, V., Khanna, D., Distler, O., Arner, I. H., Cerinic, M. M., Guiducci, S., Walker, U., Lapadula, G., Iannone, F., Becvar, R., Sierakowsky, S., Bielecka, O. K., Cutolo, M., Sulli, A., Valentini, G., Cuomo, G., Vettori, S., Riemekasten, G., Rednic, S., Nicoara, I., Kahan, A., Allanore, Y., Vlachoyiannopoulos, P., Montecucco, C., Caporali, R., Carreira, P. E., Novak, S., Varju, C., Chizzolini, C., Kucharz, E. J., Kotulska, A., Kopec Medrek, M., Widuchowska, M., Cozzi, F., Rozman, B., Mallia, C., Coleiro, B., Gabrielli, A., Farge, D., Hij, A., Airo, P., Hesselstrand, R., Scheja, A., Wollheim, F., Martinovic, D., Gurman, A. B., Braun Moscovici, Y., Govoni, Marcello, LO MONACO, Andrea, Hunzelmann, N., Pellerito, R., Bambara, L. M., Caramaschi, P., Black, C., Damjanov, N., Santamaria, V. O., Heitmann, S., Krasowska, D., Seidel, M., Oleszowsky, M., Burkhardt, H., Himsel, A., Salvador, M. J., Stamenkovic, B., Stankovic, A., Tikly, M., Starovoytova, M. N., Ananieva, L. P., Scorza, R., Engelhart, M., Strauss, G., Nielsen, H., Damgaard, K., Szucs, G., Mendoza, A. Z., Buijdos, C. d. l. P., Sifuentes Giraldo, W. A., Midtvedt, O., Garen, T., Hachulla, E., Launay, D., Valesini, G., Riccieri, V., Ionescu, R. M., Opris, D., Groseanu, L., Wigley, F. M., Mihai, C. M., Cornateanu, R. S., Ionitescu, R., Gherghe, A. M., Gorga, M., Dobrota, R., Bojinca, M., Schett, G., Distler, J. H., Meroni, P., Zeni, P., Mouthon, L., Keyser, F. D., Cantatore, F. P., Corrado, A., Ullman, S., Iversen, L., Pozzi, M. R., Eyerich, K., Hein, R., Knott, E., Szechinski, J., Wiland, P., Szmyrka Kaczmarek, M., Sokolik, R., Morgiel, E., Krummel Lorenz, B., Saar, P., Aringer, M., Gunther, C., Anic, B., Baresic, M., Mayer, M., Radominski, S. C., Muller, C. d. S., Azevedo, V. F., Agachi, S., Groppa, L., Chiaburu, L., Russu, E., Zenone, T., Highton, J., Stamp, L., Chapman, P., O'Donnell, J., Solanki, K., Doube, A., Veale, D., O'Rourke, M., Loyo, E., Li, M., Rosato, E., Pisarri, S., Tanaseanu, C. M., Popescu, M., Dumitrascu, A., Tiglea, I., Chirieac, R., Ancuta, C., Furst, D. E., Kafaja, S., Lefebvre, P. G. d. l. P., Rubio, S. R., Exposito, M. V., Sibilia, J., Chatelus, E., Gottenberg, J. E., Chifflot, H., Litinsky, I., Venalis, A., Butrimiene, I., Venalis, P., Rugiene, R., Karpec, D., Kerzberg, E., Montoya, F., Cosentino, V., Chizzolini, Carlo, Maurer, Britta, Graf, Nicole, Michel, Beat A, Müller Ladner, Ulf, Czirják, László, Denton, Christopher P, Tyndall, Alan, Metzig, Carola, Lanius, Vivian, Khanna, Dinesh, Distler, Oliver, Tarner, Ingo H, Cerinic, Marco Matucci, Guiducci, Serena, Walker, Ulrich, Lapadula, Giovanni, Iannone, Florenzo, Becvar, Radim, Sierakowsky, Stanislaw, Bielecka, Otylia Kowal, Cutolo, Maurizio, Sulli, Alberto, Valentini, Gabriele, Cuomo, Giovanna, Vettori, Serena, Riemekasten, Gabriele, Rednic, Simona, Nicoara, Ileana, Kahan, André, Allanore, Yannick, Vlachoyiannopoulos, P, Montecucco, Carlomaurizio, Caporali, Roberto, Carreira, Patricia E, Novak, Srdan, Varju, Cecilia, Kucharz, Eugene J, Kotulska, Anna, Kopec Medrek, Magdalena, Widuchowska, Malgorzata, Cozzi, Franco, Rozman, Blaz, Mallia, Carmel, Coleiro, Bernard, Gabrielli, Armando, Farge, Dominique, Hij, Adrian, Airò, Paolo, Hesselstrand, Roger, Scheja, Agneta, Wollheim, Frank, Martinovic, Duska, Gurman, Alexandra Balbir, Braun Moscovici, Yolanda, Govoni, M, Monaco, Andrea Lo, Hunzelmann, Nicola, Pellerito, Raffaele, Bambara, Lisa Maria, Caramaschi, Paola, Black, Carol, Damjanov, Nemanja, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Seidel, Matthia, Oleszowsky, Mara, Burkhardt, Harald, Himsel, Andrea, Salvador, Maria J, Stamenkovic, Bojana, Stankovic, Aleksandra, Tikly, Mohammed, Starovoytova, Maya N, Ananieva, Lidia P, Scorza, Raffaella, Engelhart, Merete, Strauss, Gitte, Nielsen, Henrik, Damgaard, Kirsten, Szücs, Gabriella, Mendoza, Antonio Zea, Buijdos, Carlos de la Puente, Giraldo, Walter A. Sifuente, Midtvedt, Øyvind, Garen, Torhild, Hachulla, Eric, Launay, David, Valesini, Guido, Riccieri, Valeria, Ionescu, Ruxandra Maria, Opris, Daniela, Groseanu, Laura, Wigley, Fredrick M, Mihai, Carmen M, Cornateanu, Roxana Sfrent, Ionitescu, Razvan, Gherghe, Ana Maria, Gorga, Marilena, Dobrota, Rucsandra, Bojinca, Mihai, Schett, Georg, Distler, Jörg HW, Meroni, Pierluigi, Zeni, Silvana, Mouthon, Luc, Keyser, Filip De, Cantatore, Francesco P, Corrado, Ada, Ullman, Susanne, Iversen, Line, Pozzi, Maria R, Eyerich, Kilian, Hein, Rüdiger, Knott, Elisabeth, Szechinski, Jacek, Wiland, Piotr, Szmyrka Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Krummel Lorenz, Brigitte, Saar, Petra, Aringer, Martin, Günther, Claudia, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Radominski, Sebastião C, Müller, Carolina de Souza, Azevedo, Valderílio F, Agachi, Svetlana, Groppa, Liliana, Chiaburu, Lealea, Russu, Eugen, Zenone, Thierry, Highton, John, Stamp, Lisa, Chapman, Peter, O'Donnell, John, Solanki, Kamal, Doube, Alan, Veale, Dougla, O’Rourke, Marie, Loyo, Esthela, Li, Mengtao, Rosato, Edoardo, Pisarri, Simonetta, Tanaseanu, Cristina Mihaela, Popescu, Monica, and University of Zurich
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Genetics and Molecular Biology (all) ,Male ,Time Factors ,Databases, Factual ,systemic sclerosis ,2745 Rheumatology ,computer.software_genre ,Biochemistry ,Severity of Illness Index ,Outcomes Research ,Qualitative Research ,Systemic Sclerosis ,Adult ,Cohort Studies ,Creatine Kinase ,Decision Support Techniques ,Deglutition Disorders ,Dyspnea ,Female ,Fibrosis ,Humans ,Logistic Models ,Middle Aged ,Multivariate Analysis ,Scleroderma, Diffuse ,Sex Factors ,Skin ,Synovitis ,Disease Progression ,Rheumatology ,Immunology ,Biochemistry, Genetics and Molecular Biology (all) ,Immunology and Allergy ,Medicine (all) ,Scleroderma ,skin fibrosis ,skin and connective tissue diseases ,ddc:616 ,EUSTAR ,Univariate analysis ,Database ,integumentary system ,10051 Rheumatology Clinic and Institute of Physical Medicine ,Orvostudományok ,Diffuse ,Connective tissue disease ,Cohort ,2723 Immunology and Allergy ,Cohort study ,medicine.medical_specialty ,610 Medicine & health ,Klinikai orvostudományok ,General Biochemistry, Genetics and Molecular Biology ,NO ,outcomes research ,qualitative research ,Databases ,1300 General Biochemistry, Genetics and Molecular Biology ,Internal medicine ,Severity of illness ,medicine ,Factual ,2403 Immunology ,business.industry ,medicine.disease ,business ,computer - Abstract
ObjectivesTo identify predictive parameters for the progression of skin fibrosis within 1 year in patients with diffuse cutaneous SSc (dcSSc).MethodsAn observational study using the EUSTAR database was performed. Inclusion criteria were dcSSc, American College of Rheumatology (ACR) criteria fulfilled, modified Rodnan skin score (MRSS) ≥7 at baseline visit, valid data for MRSS at 2nd visit, and available follow-up of 12±2 months. Worsening of skin fibrosis was defined as increase in MRSS >5 points and ≥25% from baseline to 2nd visit. In the univariate analysis, patients with progressive fibrosis were compared with non-progressors, and predictive markers with pResultsA total of 637 dcSSc patients were eligible. Univariate analyses identified joint synovitis, short disease duration (≤15 months), short disease duration in females/patients without creatine kinase (CK) elevation, low baseline MRSS (≤22/51), and absence of oesophageal symptoms as potential predictors for progressive skin fibrosis. In the multivariate analysis, by employing combinations of the predictors, 17 models with varying prediction success were generated, allowing cohort enrichment from 9.7% progressive patients in the whole cohort to 44.4% in the optimised enrichment cohort. Using a second validation cohort of 188 dcSSc patients, short disease duration, low baseline MRSS and joint synovitis were confirmed as independent predictors of progressive skin fibrosis within 1 year resulting in a 4.5-fold increased prediction success rate.ConclusionsOur study provides novel, evidence-based criteria for the enrichment of dcSSc cohorts with patients who experience worsening of skin fibrosis which allows improved clinical trial design.
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- 2014
40. Noncanonical WNT5A controls the activation of latent TGF-β to drive fibroblast activation and tissue fibrosis.
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Trinh-Minh T, Chen CW, Tran Manh C, Li YN, Zhu H, Zhou X, Chakraborty D, Zhang Y, Rauber S, Dees C, Lin NY, Kah D, Gerum R, Bergmann C, Kreuter A, Reuter C, Groeber-Becker F, Eckes B, Distler O, Fabry B, Ramming A, Schambony A, Schett G, and Distler JH
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- Fibrosis, Scleroderma, Systemic metabolism, Scleroderma, Systemic pathology, Graft vs Host Disease metabolism, Graft vs Host Disease pathology, Idiopathic Pulmonary Fibrosis metabolism, Idiopathic Pulmonary Fibrosis pathology, MAP Kinase Kinase 4 metabolism, rho-Associated Kinases metabolism, Ligands, Skin metabolism, Skin pathology, Humans, Animals, Mice, Cells, Cultured, Up-Regulation, Fibroblasts drug effects, Fibroblasts metabolism, Fibroblasts pathology, Myofibroblasts metabolism, Myofibroblasts pathology, Transforming Growth Factor beta metabolism, Wnt-5a Protein metabolism, Wnt-5a Protein pharmacology, Cell Transdifferentiation
- Abstract
Transforming growth factor β (TGF-β) signaling is a core pathway of fibrosis, but the molecular regulation of the activation of latent TGF-β remains incompletely understood. Here, we demonstrate a crucial role of WNT5A/JNK/ROCK signaling that rapidly coordinates the activation of latent TGF-β in fibrotic diseases. WNT5A was identified as a predominant noncanonical WNT ligand in fibrotic diseases such as systemic sclerosis, sclerodermatous chronic graft-versus-host disease, and idiopathic pulmonary fibrosis, stimulating fibroblast-to-myofibroblast transition and tissue fibrosis by activation of latent TGF-β. The activation of latent TGF-β requires rapid JNK- and ROCK-dependent cytoskeletal rearrangements and integrin αV (ITGAV). Conditional ablation of WNT5A or its downstream targets prevented activation of latent TGF-β, rebalanced TGF-β signaling, and ameliorated experimental fibrosis. We thus uncovered what we believe to be a novel mechanism for the aberrant activation of latent TGF-β in fibrotic diseases and provided evidence for targeting WNT5A/JNK/ROCK signaling in fibrotic diseases as a new therapeutic approach.
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- 2024
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41. Quantification of 68 Ga-FAPI-04 in systemic sclerosis-associated interstitial lung disease - Authors' reply.
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Distler JH, Bergmann C, Kuwert T, and Schmidkonz C
- Abstract
Competing Interests: The declaration of interests remains the same as in the original Article. JHWD and CB contributed equally.
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- 2021
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42. Long noncoding RNA H19X is a key mediator of TGF-β-driven fibrosis.
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Pachera E, Assassi S, Salazar GA, Stellato M, Renoux F, Wunderlin A, Blyszczuk P, Lafyatis R, Kurreeman F, de Vries-Bouwstra J, Messemaker T, Feghali-Bostwick CA, Rogler G, van Haaften WT, Dijkstra G, Oakley F, Calcagni M, Schniering J, Maurer B, Distler JH, Kania G, Frank-Bertoncelj M, and Distler O
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- Adaptor Proteins, Signal Transducing genetics, Adaptor Proteins, Signal Transducing metabolism, Animals, Cell Line, Extracellular Matrix genetics, Extracellular Matrix pathology, Humans, Mice, Myofibroblasts pathology, Pulmonary Fibrosis genetics, Pulmonary Fibrosis pathology, RNA, Long Noncoding genetics, Transforming Growth Factor beta genetics, Extracellular Matrix metabolism, Myofibroblasts metabolism, Pulmonary Fibrosis metabolism, RNA, Long Noncoding metabolism, Transforming Growth Factor beta metabolism
- Abstract
TGF-β is a master regulator of fibrosis, driving the differentiation of fibroblasts into apoptosis-resistant myofibroblasts and sustaining the production of extracellular matrix (ECM) components. Here, we identified the nuclear long noncoding RNA (lncRNA) H19X as a master regulator of TGF-β-driven tissue fibrosis. H19X was consistently upregulated in a wide variety of human fibrotic tissues and diseases and was strongly induced by TGF-β, particularly in fibroblasts and fibroblast-related cells. Functional experiments following H19X silencing revealed that H19X was an obligatory factor for TGF-β-induced ECM synthesis as well as differentiation and survival of ECM-producing myofibroblasts. We showed that H19X regulates DDIT4L gene expression, specifically interacting with a region upstream of the DDIT4L gene and changing the chromatin accessibility of a DDIT4L enhancer. These events resulted in transcriptional repression of DDIT4L and, in turn, in increased collagen expression and fibrosis. Our results shed light on key effectors of TGF-β-induced ECM remodeling and fibrosis.
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- 2020
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43. Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway.
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López-Isac E, Campillo-Davo D, Bossini-Castillo L, Guerra SG, Assassi S, Simeón CP, Carreira P, Ortego-Centeno N, García de la Peña P, Beretta L, Santaniello A, Bellocchi C, Lunardi C, Moroncini G, Gabrielli A, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Distler JH, Voskuyl AE, de Vries-Bouwstra J, Herrick A, Worthington J, Denton CP, Fonseca C, Radstake TR, Mayes MD, and Martín J
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- Case-Control Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Mutation, Missense, Scleroderma, Systemic immunology, Signal Transduction genetics, Signal Transduction immunology, Interleukin-12 physiology, Polymorphism, Single Nucleotide, Scleroderma, Systemic genetics, TYK2 Kinase genetics
- Abstract
Objectives: TYK2 is a common genetic risk factor for several autoimmune diseases. This gene encodes a protein kinase involved in interleukin 12 (IL-12) pathway, which is a well-known player in the pathogenesis of systemic sclerosis (SSc). Therefore, we aimed to assess the possible role of this locus in SSc., Methods: This study comprised a total of 7103 patients with SSc and 12 220 healthy controls of European ancestry from Spain, USA, Germany, the Netherlands, Italy and the UK. Four TYK2 single-nucleotide polymorphisms (V362F (rs2304256), P1104A (rs34536443), I684S (rs12720356) and A928V (rs35018800)) were selected for follow-up based on the results of an Immunochip screening phase of the locus. Association and dependence analyses were performed by the means of logistic regression and conditional logistic regression. Meta-analyses were performed using the inverse variance method., Results: Genome-wide significance level was reached for TYK2 V362F common variant in our pooled analysis (p=3.08×10(-13), OR=0.83), while the association of P1104A, A928V and I684S rare and low-frequency missense variants remained significant with nominal signals (p=2.28×10(-3), OR=0.80; p=1.27×10(-3), OR=0.59; p=2.63×10(-5), OR=0.83, respectively). Interestingly, dependence and allelic combination analyses showed that the strong association observed for V362F with SSc, corresponded to a synthetic association dependent on the effect of the three previously mentioned TYK2 missense variants., Conclusions: We report for the first time the association of TYK2 with SSc and reinforce the relevance of the IL-12 pathway in SSc pathophysiology., (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/)
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- 2016
- Full Text
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