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2. Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets. Report of the BIOMED-2 Concerted Action BHM4-CT98-3936

Author

Evans, P A S, Pott, Ch, Groenen, P J T A, Salles, G, Davi, F, Berger, F, Garcia, J F, van Krieken, J H J M, Pals, S, Kluin, Ph, Schuuring, E, Spaargaren, M, Boone, E, González, D, Martinez, B, Villuendas, R, Gameiro, P, Diss, T C, Mills, K, Morgan, G J, Carter, G I, Milner, B J, Pearson, D, Hummel, M, Jung, W, Ott, M, Canioni, D, Beldjord, K, Bastard, C, Delfau-Larue, M H, van Dongen, J J M, Molina, T J, and Cabeçadas, J

Published
2007
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4. EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations

Author

Langerak, A W, Groenen, P JTA, Brüggemann, M, Beldjord, K, Bellan, C, Bonello, L, Boone, E, Carter, G I, Catherwood, M, Davi, F, Delfau-Larue, M-H, Diss, T, Evans, P AS, Gameiro, P, Sanz, Garcia R, Gonzalez, D, Grand, D, Håkansson, Å, Hummel, M, Liu, H, Lombardia, L, Macintyre, E A, Milner, B J, Montes-Moreno, S, Schuuring, E, Spaargaren, M, Hodges, E, and van Dongen, J JM

Published
2012
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32. EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations

Author

Langerak, A. W., Groenen, P. J. T. A., Brueggemann, M., Beldjord, K., Bellan, C., Bonello, L., Boone, E., Carter, G. I., Catherwood, M., Davi, F., Delfau-Larue, M-H, Diss, T., Evans, P. A. S., Gameiro, P., Garcia Sanz, R., Gonzalez, D., Grand, D., Håkansson, Å., Hummel, M., Liu, H., Lombardia, L., Macintyre, E. A., Milner, B. J., Montes-Moreno, S., Schuuring, E., Spaargaren, M., Hodges, E., van Dongen, J. J. M., Langerak, A. W., Groenen, P. J. T. A., Brueggemann, M., Beldjord, K., Bellan, C., Bonello, L., Boone, E., Carter, G. I., Catherwood, M., Davi, F., Delfau-Larue, M-H, Diss, T., Evans, P. A. S., Gameiro, P., Garcia Sanz, R., Gonzalez, D., Grand, D., Håkansson, Å., Hummel, M., Liu, H., Lombardia, L., Macintyre, E. A., Milner, B. J., Montes-Moreno, S., Schuuring, E., Spaargaren, M., Hodges, E., and van Dongen, J. J. M.

Abstract

PCR-based immunoglobulin (Ig)/T-cell receptor (TCR) clonality testing in suspected lymphoproliferations has largely been standardized and has consequently become technically feasible in a routine diagnostic setting. Standardization of the pre-analytical and post-analytical phases is now essential to prevent misinterpretation and incorrect conclusions derived from clonality data. As clonality testing is not a quantitative assay, but rather concerns recognition of molecular patterns, guidelines for reliable interpretation and reporting are mandatory. Here, the EuroClonality (BIOMED-2) consortium summarizes important pre- and post-analytical aspects of clonality testing, provides guidelines for interpretation of clonality testing results, and presents a uniform way to report the results of the Ig/TCR assays. Starting from an immunobiological concept, two levels to report Ig/TCR profiles are discerned: the technical description of individual (multiplex) PCR reactions and the overall molecular conclusion for B and T cells. Collectively, the EuroClonality (BIOMED-2) guidelines and consensus reporting system should help to improve the general performance level of clonality assessment and interpretation, which will directly impact on routine clinical management (standardized best-practice) in patients with suspected lymphoproliferations.

Published
2012
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34. EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations

Author

Langerak, A.W., Groenen, P.J.T.A., Bruggemann, M., Beldjord, K., Bellan, C., Bonello, L., Boone, E., Carter, G.I., Catherwood, M., Davi, F., Delfau-Larue, M.H., Diss, T., Evans, P.A., Gameiro, P., Garcia Sanz, R., Gonzalez, D., Grand, D., Hakansson, A., Hummel, M., Liu, H., Lombardia, L., Macintyre, E.A., Milner, B.J., Montes-Moreno, S., Schuuring, E., Spaargaren, M., Hodges, E., van Dongen, J.J., Langerak, A.W., Groenen, P.J.T.A., Bruggemann, M., Beldjord, K., Bellan, C., Bonello, L., Boone, E., Carter, G.I., Catherwood, M., Davi, F., Delfau-Larue, M.H., Diss, T., Evans, P.A., Gameiro, P., Garcia Sanz, R., Gonzalez, D., Grand, D., Hakansson, A., Hummel, M., Liu, H., Lombardia, L., Macintyre, E.A., Milner, B.J., Montes-Moreno, S., Schuuring, E., Spaargaren, M., Hodges, E., and van Dongen, J.J.

Abstract

Item does not contain fulltext, PCR-based immunoglobulin (Ig)/T-cell receptor (TCR) clonality testing in suspected lymphoproliferations has largely been standardized and has consequently become technically feasible in a routine diagnostic setting. Standardization of the pre-analytical and post-analytical phases is now essential to prevent misinterpretation and incorrect conclusions derived from clonality data. As clonality testing is not a quantitative assay, but rather concerns recognition of molecular patterns, guidelines for reliable interpretation and reporting are mandatory. Here, the EuroClonality (BIOMED-2) consortium summarizes important pre- and post-analytical aspects of clonality testing, provides guidelines for interpretation of clonality testing results, and presents a uniform way to report the results of the Ig/TCR assays. Starting from an immunobiological concept, two levels to report Ig/TCR profiles are discerned: the technical description of individual (multiplex) PCR reactions and the overall molecular conclusion for B and T cells. Collectively, the EuroClonality (BIOMED-2) guidelines and consensus reporting system should help to improve the general performance level of clonality assessment and interpretation, which will directly impact on routine clinical management (standardized best-practice) in patients with suspected lymphoproliferations.

Published
2012

35. EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations

Author

Langerak, Ton, Groenen, PJTA, Bruggemann, M, Beldjord, K, Bellan, C, Bonello, L, Boone, E, Carter, GI, Catherwood, M, Davi, F, Delfau-Larue, MH, Diss, T, Evans, PAS, Gameiro, P, Sanz, RG, Gonzalez, D, Grand, D, Hakansson, A, Hummel, M, Liu, H, Lombardia, L, Macintyre, EA, Milner, BJ, Montes-Moreno, S, Schuuring, E, Spaargaren, M, Hodges, E, Dongen, Jacques, Langerak, Ton, Groenen, PJTA, Bruggemann, M, Beldjord, K, Bellan, C, Bonello, L, Boone, E, Carter, GI, Catherwood, M, Davi, F, Delfau-Larue, MH, Diss, T, Evans, PAS, Gameiro, P, Sanz, RG, Gonzalez, D, Grand, D, Hakansson, A, Hummel, M, Liu, H, Lombardia, L, Macintyre, EA, Milner, BJ, Montes-Moreno, S, Schuuring, E, Spaargaren, M, Hodges, E, and Dongen, Jacques

Abstract

PCR-based immunoglobulin (Ig)/T-cell receptor (TCR) clonality testing in suspected lymphoproliferations has largely been standardized and has consequently become technically feasible in a routine diagnostic setting. Standardization of the pre-analytical and post-analytical phases is now essential to prevent misinterpretation and incorrect conclusions derived from clonality data. As clonality testing is not a quantitative assay, but rather concerns recognition of molecular patterns, guidelines for reliable interpretation and reporting are mandatory. Here, the EuroClonality (BIOMED-2) consortium summarizes important pre- and post-analytical aspects of clonality testing, provides guidelines for interpretation of clonality testing results, and presents a uniform way to report the results of the Ig/TCR assays. Starting from an immunobiological concept, two levels to report Ig/TCR profiles are discerned: the technical description of individual (multiplex) PCR reactions and the overall molecular conclusion for B and T cells. Collectively, the EuroClonality (BIOMED-2) guidelines and consensus reporting system should help to improve the general performance level of clonality assessment and interpretation, which will directly impact on routine clinical management (standardized best-practice) in patients with suspected lymphoproliferations.

Published
2012

36. Detection of B-Catenin Gene Mutations in Paraffin-Embedded Sporadic Desmoid-Type Fibromatosis by Mutation-Specific Restriction Enzyme Digestion (MSRED): An Ancillary Diagnostic Tool

Author

UCL - Autre, Amary, M. F. C., Idowu, B., Islam, L., Bousdras, K., Pauwels, P., Meulemans, E., Diss, T. C., Flanagan, A. M., 96th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology, UCL - Autre, Amary, M. F. C., Idowu, B., Islam, L., Bousdras, K., Pauwels, P., Meulemans, E., Diss, T. C., Flanagan, A. M., and 96th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology

Published
2007

37. Immersion-histo polymerase chain reaction: a practical tool for visualization of single-copy genes in tissue sections

Author

Pan, L., Diss, T. C., Peng, H., and Isaacson, P. G.

Subjects
Histocytological Preparation Techniques, Lymphoma, B-Cell, Paraffin Embedding, Palatine Tonsil, Humans, Lymph Nodes, Microtomy, Endopeptidase K, Lymphoma, Follicular, Polymerase Chain Reaction, In Situ Hybridization, Research Article, DNA Primers
Abstract

A method, immersion-histo polymerase chain reaction (IH-PCR), was developed for visualization of single-copy DNA sequences in cells in paraffin-embedded tissue sections. Sections were mounted on coverslips, cut into small pieces, and immersed in reaction mixtures in micro-tubes for specific DNA amplification using a conventional thermal cycler. This was followed by in situ hybridization, in micro-tubes, with PCR-generated, digoxigenin-labeled probes. Epstein-Barr virus, chromosomal translocations, and rearranged immunoglobulin genes were clearly demonstrated in individual cells in human lymphomas. The use of a standard thermal cycler, the ease of probe preparation, and the high specificity and sensitivity of target localization make IH-PCR a practical and powerful tool for the study of genetic events within individual cells.

Published
1997

43. Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets. Report of the BIOMED-2 Concerted Action BHM4-CT98-3936

Author

Evans, P A S, primary, Pott, Ch, additional, Groenen, P J T A, additional, Salles, G, additional, Davi, F, additional, Berger, F, additional, Garcia, J F, additional, van Krieken, J H J M, additional, Pals, S, additional, Kluin, Ph, additional, Schuuring, E, additional, Spaargaren, M, additional, Boone, E, additional, González, D, additional, Martinez, B, additional, Villuendas, R, additional, Gameiro, P, additional, Diss, T C, additional, Mills, K, additional, Morgan, G J, additional, Carter, G I, additional, Milner, B J, additional, Pearson, D, additional, Hummel, M, additional, Jung, W, additional, Ott, M, additional, Canioni, D, additional, Beldjord, K, additional, Bastard, C, additional, Delfau-Larue, M H, additional, van Dongen, J J M, additional, Molina, T J, additional, and Cabeçadas, J, additional

Published
2006
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50. Absence of Helicobacter pylori DNA in salivary lymphoepithelial lesions.

Author

Jordan, R C, Diss, T C, Millson, C, Wilson, M, and Speight, P M

Abstract

Helicobacter pylori is a common cause of chronic gastritis and has been implicated as the main agent responsible for the development of lymphomas of mucosa associated lymphoid tissue (MALT) in the stomach. An uncommon cause of salivary gland swelling is salivary lymphoepithelial lesion (SLEL), which shows histological features of acquired MALT and is associated with the development of MALT-type lymphomas. Since H. pylori has been identified in the oral cavity, we hypothesised that this organism might act as a potential antigen for the development of MALT in salivary glands. Routinely processed biopsies of 20 SLEL were screened for H. pylori DNA using a sensitive two-stage PCR technique to amplify the 16S ribosomal RNA gene. Immunoglobulin heavy chain gene monoclonality was determined by amplifying the VDJ gene using a nested PCR technique. All SLEL had histological features of organised MALT and 14 cases showed Ig heavy chain gene monoclonality consistent with MALT lymphoma. None of the SLEL contained H. pylori DNA. In contrast to the putative role of H. pylori as an antigenic stimulus in gastric MALT lymphomas, it appears not to play a role locally in the development of MALT or MALT lymphomas of the salivary gland. [ABSTRACT FROM AUTHOR]

Published
1997
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