1. Growth hormone-releasing hormone-secreting pulmonary neuroendocrine tumor associated with pituitary hyperplasia and somatotropinoma
- Author
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Lamback, Elisa B., Henriques, Daniel G., Vazquez-Borrego, Mari C., de Azeredo Lima, Carlos H., Kasuki, Leandro, Luque, Raul M., Chimelli, Leila, Gadelha, Mônica R., [Lamback,EB, Henriques,DG, Kasuki,L, Gadelha,MR] Centro de Pesquisa em Neuroendocrinologia, Divisão de Endocrinologia, Faculdade de Medicina, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, RJ, Brasil. [Lamback,EB, de Azeredo Lima,CH, Chimelli,L, Gadelha,MR] Laboratório de Neuropatologia e Genética Molecular, Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde, Rio de Janeiro, RJ, Brasil. [Lamback,EB, Gadelha,MR] Unidade de Neuroendocrinologia, Instituto Estadual do Cérebro Paulo Niemeyer, Secretaria Estadual de Saúde, Rio de Janeiro, RJ, Brasil. [Vazquez-Borrego,MC, Luque,RM] Instituto Maimónides de Pesquisas Biomédicas de Córdoba (IMIBIC), Córdoba, Espanha. [Vazquez-Borrego,MC, Luque,RM] Departamento de Biologia Celular, Fisiologia e Imunologia, Universidade de Córdoba, Córdoba, Espanha. [Vazquez-Borrego,MC, Luque,RM] Hospital Universitário Reina Sofia (HURS), Córdoba, Espanha. [Vazquez-Borrego,MC, and Luque,RM] CIBER Fisiopatologia da Obesidade e Nutrição (CIBERobn), Córdoba, Espanha. [Kasuki,L] Divisão de Endocrinologia, Hospital Federal de Bonsucesso, Rio de Janeiro, RJ, Brasil
- Subjects
Hyperplasia ,Anatomy::Endocrine System::Endocrine Glands::Pituitary Gland::Pituitary Gland, Anterior::Somatotrophs [Medical Subject Headings] ,Check Tags::Male [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Magnetic Resonance Imaging [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Radiography [Medical Subject Headings] ,Tumores neuroendocrinos ,Anatomy::Respiratory System::Lung [Medical Subject Headings] ,Pituitary adenoma ,Hiperplasia ,Acromegalia ,Diseases::Endocrine System Diseases::Pituitary Diseases::Pituitary Apoplexy [Medical Subject Headings] ,Acromegaly ,Neoplasias hipofisarias ,Diseases::Endocrine System Diseases::Pituitary Diseases::Pituitary Neoplasms [Medical Subject Headings] ,Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Nerve Tissue::Neuroectodermal Tumors::Neuroendocrine Tumors [Medical Subject Headings] ,Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Hyperplasia [Medical Subject Headings] ,Neuroendocrine tumors ,Hormona liberadora de hormona del crecimiento ,Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Hypothalamic Hormones::Pituitary Hormone-Releasing Hormones::Growth Hormone-Releasing Hormone [Medical Subject Headings] ,Persons::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings] ,Persons::Persons::Age Groups::Adult [Medical Subject Headings] ,Diseases::Endocrine System Diseases::Pituitary Diseases::Hyperpituitarism::Acromegaly [Medical Subject Headings] ,Growth hormone-releasing hormone - Abstract
Acromegaly caused by ectopic growth hormone-releasing hormone (GHRH)-secreting tumor is exceedingly rare. We report a case of acromegaly secondary to GHRH secretion by an incidentally diagnosed pulmonary neuroendocrine tumor (NET) and review 47 similar cases in literature. A 22-year-old male patient presented with symptoms of pituitary apoplexy. Magnetic resonance imaging (MRI) showed apoplexy of a pituitary adenoma. Routinely prior to surgery, a chest radiography was performed which revealed a mass in the left lung. During investigation, the patient was diagnosed with metastatic GHRH-secreting pulmonary NET. In retrospect, it was noted that the patient had pituitary hyperplasia 20 months prior to the MRI which showed the presence of a pituitary adenoma. The histological findings confirmed somatotroph hyperplasia adjacent to somatotropinoma. This case suggests that GHRH secretion can be associated with pituitary hyperplasia, which may be followed by pituitary adenoma formation. Yes
- Published
- 2021