Search

Your search keyword '"Dirks, P. B."' showing total 135 results
Start Over Author "Dirks, P. B."
135 results on '"Dirks, P. B."'

1. Single-cell atlas of the human brain vasculature across development, adulthood and disease

Author

Wälchli, Thomas, Ghobrial, Moheb, Schwab, Marc, Takada, Shigeki, Zhong, Hang, Suntharalingham, Samuel, Vetiska, Sandra, Gonzalez, Daymé Rodrigues, Wu, Ruilin, Rehrauer, Hubert, Dinesh, Anuroopa, Yu, Kai, Chen, Edward L. Y., Bisschop, Jeroen, Farnhammer, Fiona, Mansur, Ann, Kalucka, Joanna, Tirosh, Itay, Regli, Luca, Schaller, Karl, Frei, Karl, Ketela, Troy, Bernstein, Mark, Kongkham, Paul, Carmeliet, Peter, Valiante, Taufik, Dirks, Peter B., Suva, Mario L., Zadeh, Gelareh, Tabar, Viviane, Schlapbach, Ralph, Jackson, Hartland W., De Bock, Katrien, Fish, Jason E., Monnier, Philippe P., Bader, Gary D., and Radovanovic, Ivan

Published
2024
Full Text
View/download PDF

3. A designer peptide against the EAG2–Kvβ2 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma

Author

Dong, Weifan, Fekete, Adam, Chen, Xiaodi, Liu, Hongwei, Beilhartz, Greg L., Chen, Xin, Bahrampour, Shahrzad, Xiong, Yi, Yang, Qi, Zhao, Hongyu, Kong, Tian, Morioka, Malia S., Jung, Geena, Kim, Ji-Eun, Schramek, Daniel, Dirks, Peter B., Song, Yuanquan, Kim, Tae-Hee, He, Ye, Wanggou, Siyi, Li, Xuejun, Melnyk, Roman A., Wang, Lu-Yang, and Huang, Xi

Published
2023
Full Text
View/download PDF

4. macroH2A2 antagonizes epigenetic programs of stemness in glioblastoma

Author

Nikolic, Ana, Maule, Francesca, Bobyn, Anna, Ellestad, Katrina, Paik, Seungil, Marhon, Sajid A., Mehdipour, Parinaz, Lun, Xueqing, Chen, Huey-Miin, Mallard, Claire, Hay, Alexander J., Johnston, Michael J., Gafuik, Christopher J., Zemp, Franz J., Shen, Yaoqing, Ninkovic, Nicoletta, Osz, Katalin, Labit, Elodie, Berger, N. Daniel, Brownsey, Duncan K., Kelly, John J., Biernaskie, Jeff, Dirks, Peter B., Derksen, Darren J., Jones, Steven J. M., Senger, Donna L., Chan, Jennifer A., Mahoney, Douglas J., De Carvalho, Daniel D., and Gallo, Marco

Published
2023
Full Text
View/download PDF

6. Translating Basic Science Discoveries into Improved Outcomes for Glioblastoma

Author

Dirks, Peter B, Gilbert, Mark R, Holland, Eric C, Maher, Elizabeth A, and Weiss, William A

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Brain Cancer, Brain Disorders, Neurosciences, Cancer, Antineoplastic Agents, Glioblastoma, Humans, Molecular Targeted Therapy, Translational Research, Biomedical, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

Members of the scientific and clinical neuro-oncology community met in April 2019 to discuss the current challenges and opportunities associated with translating basic science discoveries in glioblastoma for improved survival of patients. A summary of key points of these discussions is presented in this article.

Published
2020

7. Roadmap for the Emerging Field of Cancer Neuroscience

Author

Monje, Michelle, Borniger, Jeremy C, D’Silva, Nisha J, Deneen, Benjamin, Dirks, Peter B, Fattahi, Faranak, Frenette, Paul S, Garzia, Livia, Gutmann, David H, Hanahan, Douglas, Hervey-Jumper, Shawn L, Hondermarck, Hubert, Hurov, Jonathan B, Kepecs, Adam, Knox, Sarah M, Lloyd, Alison C, Magnon, Claire, Saloman, Jami L, Segal, Rosalind A, Sloan, Erica K, Sun, Xin, Taylor, Michael D, Tracey, Kevin J, Trotman, Lloyd C, Tuveson, David A, Wang, Timothy C, White, Ruth A, and Winkler, Frank

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Neurosciences, Cancer, 2.1 Biological and endogenous factors, Aetiology, Humans, Neoplasms, Nervous System, Biological Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Mounting evidence indicates that the nervous system plays a central role in cancer pathogenesis. In turn, cancers and cancer therapies can alter nervous system form and function. This Commentary seeks to describe the burgeoning field of "cancer neuroscience" and encourage multidisciplinary collaboration for the study of cancer-nervous system interactions.

Published
2020

9. Two-Stage Testing Reduces Student-Perceived Exam Anxiety in Introductory Chemistry

Author

Rempel, Brian P., Dirks, Maria B., and McGinitie, Elizabeth G.

Abstract

Two-stage quizzes and exams were implemented for both in-class quizzes and term tests in three sections of first-year General (Introductory) Chemistry. In the first stage, students completed the exam individually and submitted their papers. In the second stage, students collaborated with peers to complete a subset of the exam questions. The aim of the first stage was to evaluate students' individual knowledge, while the second stage provided an opportunity for peer-led learning. Exam scores were calculated as a blend of scores on the two stages, between 80 and 85% for the first (individual) stage and 20-15% for the second (collaborative) stage. Students' (total n = 129) written responses to open-ended questions in a long-answer student survey comparing two-stage and one-stage (in which there is only the individual portion) tests were qualitatively coded by thematic analysis, with themes developed through a grounded theory approach. The most significant conclusion was that students perceived that the two-stage test format helped to partially (but by no means fully) alleviate student exam anxiety when compared to a traditional one-stage test. Student responses were primarily positive about the two-stage format rather than negative about the one-stage format. The most common themes that emerged from student responses centered on: (1) improvement in grades, (2) positive discussion with peers, (3) immediate feedback from peers, and (4) less (perceived) pressure. Finally, students also expressed a very strong overall preference for two-stage over one-stage tests.

Published
2021
Full Text
View/download PDF

10. A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor

Author

Sin-Chan, Patrick, Mumal, Iqra, Suwal, Tannu, Ho, Ben, Fan, Xiaolian, Singh, Irtisha, Du, Yuchen, Lu, Mei, Patel, Neilket, Torchia, Jonathon, Popovski, Dean, Fouladi, Maryam, Guilhamon, Paul, Hansford, Jordan R, Leary, Sarah, Hoffman, Lindsey M, Levy, Jean M Mulcahy, Lassaletta, Alvaro, Solano-Paez, Palma, Rivas, Eloy, Reddy, Alyssa, Gillespie, G Yancey, Gupta, Nalin, Van Meter, Timothy E, Nakamura, Hideo, Wong, Tai-Tong, Ra, Young-Shin, Kim, Seung-Ki, Massimi, Luca, Grundy, Richard G, Fangusaro, Jason, Johnston, Donna, Chan, Jennifer, Lafay-Cousin, Lucie, Hwang, Eugene I, Wang, Yin, Catchpoole, Daniel, Michaud, Jean, Ellezam, Benjamin, Ramanujachar, Ramya, Lindsay, Holly, Taylor, Michael D, Hawkins, Cynthia E, Bouffet, Eric, Jabado, Nada, Singh, Sheila K, Kleinman, Claudia L, Barsyte-Lovejoy, Dalia, Li, Xiao-Nan, Dirks, Peter B, Lin, Charles Y, Mack, Stephen C, Rich, Jeremy N, and Huang, Annie

Subjects
Rare Diseases, Neurosciences, Cancer, Genetics, Biotechnology, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Biomarkers, Tumor, Brain Neoplasms, Cell Cycle, Cell Transformation, Neoplastic, Chromosomes, Human, Pair 19, Chromosomes, Human, Pair 2, DNA Copy Number Variations, Enhancer Elements, Genetic, Epigenesis, Genetic, Gene Expression Regulation, Gene Regulatory Networks, Genetic Association Studies, Genetic Predisposition to Disease, Humans, MicroRNAs, Models, Biological, Multigene Family, N-Myc Proto-Oncogene Protein, Neoplasms, Germ Cell and Embryonal, Oncogenes, RNA-Binding Proteins, C19MC, ETMR, LIN28A, MYCN, brain tumor, cell-cycle, epigenetics, microRNA, super-enhancer, therapeutics, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Embryonal tumors with multilayered rosettes (ETMRs) are highly lethal infant brain cancers with characteristic amplification of Chr19q13.41 miRNA cluster (C19MC) and enrichment of pluripotency factor LIN28A. Here we investigated C19MC oncogenic mechanisms and discovered a C19MC-LIN28A-MYCN circuit fueled by multiple complex regulatory loops including an MYCN core transcriptional network and super-enhancers resulting from long-range MYCN DNA interactions and C19MC gene fusions. Our data show that this powerful oncogenic circuit, which entraps an early neural lineage network, is potently abrogated by bromodomain inhibitor JQ1, leading to ETMR cell death.

Published
2019

14. Berkeley's New Approach to Global Engagement: Early and Current Efforts to Become More International. Research & Occasional Paper Series: CSHE.12.15

Author

University of California, Berkeley. Center for Studies in Higher Education, Dirks, Nicholas B., and Gilman, Nils

Abstract

This essay discusses past and current thinking about the globalization of higher education (from a U.S. point of view in particular) and a new model we are attempting to develop at the University of California, Berkeley. This essay begins with a brief narrative of the historical evolution of efforts to internationalize education, from the seventeenth century to the present day, before providing a schematic outline of efforts to create new models for the global university. From its earliest beginnings in the U.S. and elsewhere, higher education embodied important global dimensions. Since then, the globalization of higher education has accelerated rapidly over the last quarter century, motivated by a quest for additional revenues (especially in the case of Anglophone universities), a desire for greater international relevance and hence prestige (for all universities, but especially in the case of European and Asian universities), and a desire to provide a foundation for a knowledge economy (especially in the case of Asian universities).

Published
2015

15. The Liberal Arts and the University: Tracing the Origins and Structure of Undergraduate Education in the US and at the University of California. Research & Occasional Paper Series: CSHE.7.15

Author

University of California, Berkeley. Center for Studies in Higher Education and Dirks, Nicholas B.

Abstract

As the University of California continues to face unprecedented challenges--from state disinvestment, to attempts by the legislature to wrest control of the university, to disruption brought on by new technology, to concerns, valid or otherwise, about the value of college--university leaders must return to fundamental questions about the purposes of higher education to guide us in our decision making. With this essay, I look back at how we arrived at contemporary understandings of undergraduate education in order to show that today's dominant debates--regarding the purpose of higher education, its benefit to society, its benefit to individuals, its role in the economy, how curricula and the university itself should be structured, who should pursue a university education, and who should fund it--have in fact been meaningfully shaping institutions of higher education for centuries. I hope to show, too, that the system of public higher education that developed in the United States--and, particularly, in California--is exceptional, and worth not only preserving, but also enhancing and strengthening, given its unique contributions to economic growth, innovation, socioeconomic mobility, civic engagement, and cultural vitality, both for the state and for the world.

Published
2015

17. Intertumoral Heterogeneity within Medulloblastoma Subgroups

Author

Cavalli, Florence MG, Remke, Marc, Rampasek, Ladislav, Peacock, John, Shih, David JH, Luu, Betty, Garzia, Livia, Torchia, Jonathon, Nor, Carolina, Morrissy, A Sorana, Agnihotri, Sameer, Thompson, Yuan Yao, Kuzan-Fischer, Claudia M, Farooq, Hamza, Isaev, Keren, Daniels, Craig, Cho, Byung-Kyu, Kim, Seung-Ki, Wang, Kyu-Chang, Lee, Ji Yeoun, Grajkowska, Wieslawa A, Perek-Polnik, Marta, Vasiljevic, Alexandre, Faure-Conter, Cecile, Jouvet, Anne, Giannini, Caterina, Rao, Amulya A Nageswara, Li, Kay Ka Wai, Ng, Ho-Keung, Eberhart, Charles G, Pollack, Ian F, Hamilton, Ronald L, Gillespie, G Yancey, Olson, James M, Leary, Sarah, Weiss, William A, Lach, Boleslaw, Chambless, Lola B, Thompson, Reid C, Cooper, Michael K, Vibhakar, Rajeev, Hauser, Peter, van Veelen, Marie-Lise C, Kros, Johan M, French, Pim J, Ra, Young Shin, Kumabe, Toshihiro, López-Aguilar, Enrique, Zitterbart, Karel, Sterba, Jaroslav, Finocchiaro, Gaetano, Massimino, Maura, Van Meir, Erwin G, Osuka, Satoru, Shofuda, Tomoko, Klekner, Almos, Zollo, Massimo, Leonard, Jeffrey R, Rubin, Joshua B, Jabado, Nada, Albrecht, Steffen, Mora, Jaume, Van Meter, Timothy E, Jung, Shin, Moore, Andrew S, Hallahan, Andrew R, Chan, Jennifer A, Tirapelli, Daniela PC, Carlotti, Carlos G, Fouladi, Maryam, Pimentel, José, Faria, Claudia C, Saad, Ali G, Massimi, Luca, Liau, Linda M, Wheeler, Helen, Nakamura, Hideo, Elbabaa, Samer K, Perezpeña-Diazconti, Mario, de León, Fernando Chico Ponce, Robinson, Shenandoah, Zapotocky, Michal, Lassaletta, Alvaro, Huang, Annie, Hawkins, Cynthia E, Tabori, Uri, Bouffet, Eric, Bartels, Ute, Dirks, Peter B, Rutka, James T, Bader, Gary D, Reimand, Jüri, Goldenberg, Anna, Ramaswamy, Vijay, and Taylor, Michael D

Subjects
Genetics, Rare Diseases, Pediatric Cancer, Cancer, Brain Cancer, Pediatric Research Initiative, Pediatric, Human Genome, Brain Disorders, Cluster Analysis, Cohort Studies, DNA Copy Number Variations, DNA Methylation, Gene Expression Profiling, Genomics, Humans, Medulloblastoma, Precision Medicine, copy number, gene expression, integrative clustering, medulloblastoma, methylation, subgroups, Neurosciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials.

Published
2017

18. Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity

Author

Richards, Laura M., Whitley, Owen K. N., MacLeod, Graham, Cavalli, Florence M. G., Coutinho, Fiona J., Jaramillo, Julia E., Svergun, Nataliia, Riverin, Mazdak, Croucher, Danielle C., Kushida, Michelle, Yu, Kenny, Guilhamon, Paul, Rastegar, Naghmeh, Ahmadi, Moloud, Bhatti, Jasmine K., Bozek, Danielle A., Li, Naijin, Lee, Lilian, Che, Clare, Luis, Erika, Park, Nicole I., Xu, Zhiyu, Ketela, Troy, Moore, Richard A., Marra, Marco A., Spears, Julian, Cusimano, Michael D., Das, Sunit, Bernstein, Mark, Haibe-Kains, Benjamin, Lupien, Mathieu, Luchman, H. Artee, Weiss, Samuel, Angers, Stephane, Dirks, Peter B., Bader, Gary D., and Pugh, Trevor J.

Published
2021
Full Text
View/download PDF

19. BERKELEY'S NEW APPROACH TO GLOBAL ENGAGEMENT: EARLY & CURRENT EFFORTS TO BECOME MORE INTERNATIONAL

Author

Dirks, Nicolas B and Gilman, Nils

Abstract

This essay discusses past and current thinking about the globalization of higher education (from a U.S. point of view in particular) and a new model we are attempting to develop at the University of California, Berkeley. This essay begins with a brief narrative of the historical evolution of efforts to internationalize education, from the seventeenth century to the present day, before providing a schematic outline of efforts to create new models for the global university. From its earliest beginnings in the U.S. and elsewhere, higher education embodied important global dimensions. Since then, the globalization of higher education has accelerated rapidly over the last quarter century, motivated by a quest for additional revenues (especially in the case of Anglophone universities), a desire for greater international relevance and hence prestige (for all universities, but especially in the case of European and Asian universities), and a desire to provide a foundation for a knowledge economy (especially in the case of Asian universities)

Published
2015

20. The white matter is a pro-differentiative niche for glioblastoma

Author

Brooks, Lucy J., Clements, Melanie P., Burden, Jemima J., Kocher, Daniela, Richards, Luca, Devesa, Sara Castro, Zakka, Leila, Woodberry, Megan, Ellis, Michael, Jaunmuktane, Zane, Brandner, Sebastian, Morrison, Gillian, Pollard, Steven M., Dirks, Peter B., Marguerat, Samuel, and Parrinello, Simona

Published
2021
Full Text
View/download PDF

21. PRMT5 inhibition disrupts splicing and stemness in glioblastoma

Author

Sachamitr, Patty, Ho, Jolene C., Ciamponi, Felipe E., Ba-Alawi, Wail, Coutinho, Fiona J., Guilhamon, Paul, Kushida, Michelle M., Cavalli, Florence M. G., Lee, Lilian, Rastegar, Naghmeh, Vu, Victoria, Sánchez-Osuna, María, Coulombe-Huntington, Jasmin, Kanshin, Evgeny, Whetstone, Heather, Durand, Mathieu, Thibault, Philippe, Hart, Kirsten, Mangos, Maria, Veyhl, Joseph, Chen, Wenjun, Tran, Nhat, Duong, Bang-Chi, Aman, Ahmed M., Che, Xinghui, Lan, Xiaoyang, Whitley, Owen, Zaslaver, Olga, Barsyte-Lovejoy, Dalia, Richards, Laura M., Restall, Ian, Caudy, Amy, Röst, Hannes L., Bonday, Zahid Quyoom, Bernstein, Mark, Das, Sunit, Cusimano, Michael D., Spears, Julian, Bader, Gary D., Pugh, Trevor J., Tyers, Mike, Lupien, Mathieu, Haibe-Kains, Benjamin, Artee Luchman, H., Weiss, Samuel, Massirer, Katlin B., Prinos, Panagiotis, Arrowsmith, Cheryl H., and Dirks, Peter B.

Published
2021
Full Text
View/download PDF

23. Stalled developmental programs at the root of pediatric brain tumors

Author

Jessa, Selin, Blanchet-Cohen, Alexis, Krug, Brian, Vladoiu, Maria, Coutelier, Marie, Faury, Damien, Poreau, Brice, De Jay, Nicolas, Hébert, Steven, Monlong, Jean, Farmer, W. Todd, Donovan, Laura K., Hu, Yixing, McConechy, Melissa K., Cavalli, Florence M. G., Mikael, Leonie G., Ellezam, Benjamin, Richer, Maxime, Allaire, Andréa, Weil, Alexander G., Atkinson, Jeffrey, Farmer, Jean-Pierre, Dudley, Roy W. R., Larouche, Valerie, Crevier, Louis, Albrecht, Steffen, Filbin, Mariella G., Sartelet, Hervé, Lutz, Pierre-Eric, Nagy, Corina, Turecki, Gustavo, Costantino, Santiago, Dirks, Peter B., Murai, Keith K., Bourque, Guillaume, Ragoussis, Jiannis, Garzia, Livia, Taylor, Michael D., Jabado, Nada, and Kleinman, Claudia L.

Published
2019
Full Text
View/download PDF

24. GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer

Author

Wu, Qin, ba-alawi, Wail, Deblois, Genevieve, Cruickshank, Jennifer, Duan, Shili, Lima-Fernandes, Evelyne, Haight, Jillian, Tonekaboni, Seyed Ali Madani, Fortier, Anne-Marie, Kuasne, Hellen, McKee, Trevor D., Mahmoud, Hassan, Kushida, Michelle, Cameron, Sarina, Dogan-Artun, Nergiz, Chen, WenJun, Nie, Yan, Zhang, Lan Xin, Vellanki, Ravi N., Zhou, Stanley, Prinos, Panagiotis, Wouters, Bradly G., Dirks, Peter B., Done, Susan J., Park, Morag, Cescon, David W., Haibe-Kains, Benjamin, Lupien, Mathieu, and Arrowsmith, Cheryl H.

Published
2020
Full Text
View/download PDF

25. The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants

Author

Pajtler, Kristian W., Mack, Stephen C., Ramaswamy, Vijay, Smith, Christian A., Witt, Hendrik, Smith, Amy, Hansford, Jordan R., von Hoff, Katja, Wright, Karen D., Hwang, Eugene, Frappaz, Didier, Kanemura, Yonehiro, Massimino, Maura, Faure-Conter, Cécile, Modena, Piergiorgio, Tabori, Uri, Warren, Katherine E., Holland, Eric C., Ichimura, Koichi, Giangaspero, Felice, Castel, David, von Deimling, Andreas, Kool, Marcel, Dirks, Peter B., Grundy, Richard G., Foreman, Nicholas K., Gajjar, Amar, Korshunov, Andrey, Finlay, Jonathan, Gilbertson, Richard J., Ellison, David W., Aldape, Kenneth D., Merchant, Thomas E., Bouffet, Eric, Pfister, Stefan M., and Taylor, Michael D.

Published
2017
Full Text
View/download PDF

28. Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells

Author

Barszczyk, Mark, Buczkowicz, Pawel, Castelo-Branco, Pedro, Mack, Stephen C., Ramaswamy, Vijay, Mangerel, Joshua, Agnihotri, Sameer, Remke, Marc, Golbourn, Brian, Pajovic, Sanja, Elizabeth, Cynthia, Yu, Man, Luu, Betty, Morrison, Andrew, Adamski, Jennifer, Nethery-Brokx, Kathleen, Li, Xiao-Nan, Van Meter, Timothy, Dirks, Peter B., Rutka, James T., Taylor, Michael D., Tabori, Uri, and Hawkins, Cynthia

Published
2014
Full Text
View/download PDF

29. Alternative lengthening of telomeres is enriched in, and impacts survival of TP53 mutant pediatric malignant brain tumors

Author

Mangerel, Joshua, Price, Aryeh, Castelo-Branco, Pedro, Brzezinski, Jack, Buczkowicz, Pawel, Rakopoulos, Patricia, Merino, Diana, Baskin, Berivan, Wasserman, Jonathan, Mistry, Matthew, Barszczyk, Mark, Picard, Daniel, Mack, Stephen, Remke, Marc, Starkman, Hava, Elizabeth, Cynthia, Zhang, Cindy, Alon, Noa, Lees, Jodi, Andrulis, Irene L., Wunder, Jay S., Jabado, Nada, Johnston, Donna L., Rutka, James T., Dirks, Peter B., Bouffet, Eric, Taylor, Michael D., Huang, Annie, Malkin, David, Hawkins, Cynthia, and Tabori, Uri

Published
2014
Full Text
View/download PDF

30. CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity

Author

Spence, Tara, Sin-Chan, Patrick, Picard, Daniel, Barszczyk, Mark, Hoss, Katharina, Lu, Mei, Kim, Seung-Ki, Ra, Young-Shin, Nakamura, Hideo, Fangusaro, Jason, Hwang, Eugene, Kiehna, Erin, Toledano, Helen, Wang, Yin, Shi, Qing, Johnston, Donna, Michaud, Jean, La Spina, Milena, Buccoliero, Anna Maria, Adamek, Dariusz, Camelo-Piragua, Sandra, Peter Collins, V., Jones, Chris, Kabbara, Nabil, Jurdi, Nawaf, Varlet, Pascale, Perry, Arie, Scharnhorst, David, Fan, Xing, Muraszko, Karin M., Eberhart, Charles G., Ng, Ho-Keung, Gururangan, Sridharan, Van Meter, Timothy, Remke, Marc, Lafay-Cousin, Lucie, Chan, Jennifer A., Sirachainan, Nongnuch, Pomeroy, Scott L., Clifford, Steven C., Gajjar, Amar, Shago, Mary, Halliday, William, Taylor, Michael D., Grundy, Richard, Lau, Ching C., Phillips, Joanna, Bouffet, Eric, Dirks, Peter B., Hawkins, Cynthia E., and Huang, Annie

Published
2014
Full Text
View/download PDF

31. TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

Author

Remke, Marc, Ramaswamy, Vijay, Peacock, John, Shih, David J. H., Koelsche, Christian, Northcott, Paul A., Hill, Nadia, Cavalli, Florence M. G., Kool, Marcel, Wang, Xin, Mack, Stephen C., Barszczyk, Mark, Morrissy, A. Sorana, Wu, Xiaochong, Agnihotri, Sameer, Luu, Betty, Jones, David T. W., Garzia, Livia, Dubuc, Adrian M., Zhukova, Nataliya, Vanner, Robert, Kros, Johan M., French, Pim J., Van Meir, Erwin G., Vibhakar, Rajeev, Zitterbart, Karel, Chan, Jennifer A., Bognár, László, Klekner, Almos, Lach, Boleslaw, Jung, Shin, Saad, Ali G., Liau, Linda M., Albrecht, Steffen, Zollo, Massimo, Cooper, Michael K., Thompson, Reid C., Delattre, Oliver O., Bourdeaut, Franck, Doz, François F., Garami, Miklós, Hauser, Peter, Carlotti, Carlos G., Van Meter, Timothy E., Massimi, Luca, Fults, Daniel, Pomeroy, Scott L., Kumabe, Toshiro, Ra, Young Shin, Leonard, Jeffrey R., Elbabaa, Samer K., Mora, Jaume, Rubin, Joshua B., Cho, Yoon-Jae, McLendon, Roger E., Bigner, Darell D., Eberhart, Charles G., Fouladi, Maryam, Wechsler-Reya, Robert J., Faria, Claudia C., Croul, Sidney E., Huang, Annie, Bouffet, Eric, Hawkins, Cynthia E., Dirks, Peter B., Weiss, William A., Schüller, Ulrich, Pollack, Ian F., Rutkowski, Stefan, Meyronet, David, Jouvet, Anne, Fèvre-Montange, Michelle, Jabado, Nada, Perek-Polnik, Marta, Grajkowska, Wieslawa A., Kim, Seung-Ki, Rutka, James T., Malkin, David, Tabori, Uri, Pfister, Stefan M., Korshunov, Andrey, von Deimling, Andreas, and Taylor, Michael D.

Published
2013
Full Text
View/download PDF

34. Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

Author

Mack, S. C., Witt, H., Piro, R. M., Gu, L., Zuyderduyn, S., Stütz, A. M., Wang, X., Gallo, M., Garzia, L., Zayne, K., Zhang, X., Ramaswamy, V., Jäger, N., Jones, D. T. W., Sill, M., Pugh, T. J., Ryzhova, M., Wani, K. M., Shih, D. J. H., Head, R., Remke, M., Bailey, S. D., Zichner, T., Faria, C. C., Barszczyk, M., Stark, S., Seker-Cin, H., Hutter, S., Johann, P., Bender, S., Hovestadt, V., Tzaridis, T., Dubuc, A. M., Northcott, P. A., Peacock, J., Bertrand, K. C., Agnihotri, S., Cavalli, F. M. G., Clarke, I., Nethery-Brokx, K., Creasy, C. L., Verma, S. K., Koster, J., Wu, X., Yao, Y., Milde, T., Sin-Chan, P., Zuccaro, J., Lau, L., Pereira, S., Castelo-Branco, P., Hirst, M., Marra, M. A., Roberts, S. S., Fults, D., Massimi, L., Cho, Y. J., Van Meter, T., Grajkowska, W., Lach, B., Kulozik, A. E., von Deimling, A., Witt, O., Scherer, S. W., Fan, X., Muraszko, K. M., Kool, M., Pomeroy, S. L., Gupta, N., Phillips, J., Huang, A., Tabori, U., Hawkins, C., Malkin, D., Kongkham, P. N., Weiss, W. A., Jabado, N., Rutka, J. T., Bouffet, E., Korbel, J. O., Lupien, M., Aldape, K. D., Bader, G. D., Eils, R., Lichter, P., Dirks, P. B., Pfister, S. M., Korshunov, A., and Taylor, M. D.

Published
2014
Full Text
View/download PDF

35. Protocol for the derivation of primary cancer stem cell lines from human ependymal tumors

Author

Richman, Cory M., Dirks, Peter B., Taylor, Michael D., and Michealraj, Kulandaimanuvel Antony

Abstract

Cancer stem cells (CSCs) established from surgical biopsies closely mimic the human context and can be used to investigate disease mechanisms, genetic fitness, and therapeutic evaluation. Here, we present a protocol for the derivation of primary patient-derived CSC lines from ependymal tumors. We describe the necessary steps, from surgical intervention and biopsy to the dissociation of ependymomas to derive cultures. We then detail procedures for cell line propagation and define the characteristics of these primary cancer cell lines.

Published
2024
Full Text
View/download PDF

47. A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor

Author

Sin-Chan, P., Mumal, I., Suwal, T., Ho, B., Fan, X., Singh, I., Du, Y., Lu, M., Patel, N., Torchia, J., Popovski, D., Fouladi, M., Guilhamon, P., Hansford, J. R., Leary, S., Hoffman, L. M., Mulcahy Levy, J. M., Lassaletta, A., Solano-Paez, P., Rivas, E., Reddy, A., Gillespie, G. Y., Gupta, N., Van Meter, T. E., Nakamura, H., Wong, T. -T., Ra, Y. -S., Kim, S. -K., Massimi, Luca, Grundy, R. G., Fangusaro, J., Johnston, D., Chan, J., Lafay-Cousin, L., Hwang, E. I., Wang, Y., Catchpoole, D., Michaud, J., Ellezam, B., Ramanujachar, R., Lindsay, H., Taylor, M. D., Hawkins, C. E., Bouffet, E., Jabado, N., Singh, S. K., Kleinman, C. L., Barsyte-Lovejoy, D., Li, X. -N., Dirks, P. B., Lin, C. Y., Mack, S. C., Rich, J. N., Huang, A., Massimi L., Sin-Chan, P., Mumal, I., Suwal, T., Ho, B., Fan, X., Singh, I., Du, Y., Lu, M., Patel, N., Torchia, J., Popovski, D., Fouladi, M., Guilhamon, P., Hansford, J. R., Leary, S., Hoffman, L. M., Mulcahy Levy, J. M., Lassaletta, A., Solano-Paez, P., Rivas, E., Reddy, A., Gillespie, G. Y., Gupta, N., Van Meter, T. E., Nakamura, H., Wong, T. -T., Ra, Y. -S., Kim, S. -K., Massimi, Luca, Grundy, R. G., Fangusaro, J., Johnston, D., Chan, J., Lafay-Cousin, L., Hwang, E. I., Wang, Y., Catchpoole, D., Michaud, J., Ellezam, B., Ramanujachar, R., Lindsay, H., Taylor, M. D., Hawkins, C. E., Bouffet, E., Jabado, N., Singh, S. K., Kleinman, C. L., Barsyte-Lovejoy, D., Li, X. -N., Dirks, P. B., Lin, C. Y., Mack, S. C., Rich, J. N., Huang, A., and Massimi L.

Abstract

Embryonal tumors with multilayered rosettes (ETMRs) are highly lethal infant brain cancers with characteristic amplification of Chr19q13.41 miRNA cluster (C19MC) and enrichment of pluripotency factor LIN28A. Here we investigated C19MC oncogenic mechanisms and discovered a C19MC-LIN28A-MYCN circuit fueled by multiple complex regulatory loops including an MYCN core transcriptional network and super-enhancers resulting from long-range MYCN DNA interactions and C19MC gene fusions. Our data show that this powerful oncogenic circuit, which entraps an early neural lineage network, is potently abrogated by bromodomain inhibitor JQ1, leading to ETMR cell death. Sin-Chan et al. uncover a C19MC-LIN28A-MYCN super-enhancer-dependent oncogenic circuit in embryonal tumors with multilayered rosettes (ETMRs). The circuit entraps an early neural lineage network to sustain embryonic epigenetic programming and is vulnerable to bromodomain inhibition, which promotes ETMR cell death.

Published
2019

48. Scholars, Spies, and Global Studies

Author

Dirks, Nicholas B.

Abstract

No one doubts that globalization is one of the most important trends of today. As American universities expand their global footprint with branch campuses in Singapore, Abu Dhabi, and elsewhere, many faculty are concerned about oppressive governance, human-rights violations, and lack of academic freedom abroad. Meanwhile administrators grapple with how these new ventures--and globalization in general--will change teaching and research in the United States. As higher education seeks new audiences, will it be able to maintain the significance and character of the liberal arts, which have played such a crucial role in the educational mission of the American university? Similarly educators increasingly agree that all undergraduates ought to pursue some study abroad. But should it involve language study and full cultural immersion? Or short-term travel and networking through internships and other kinds of programs? What does "global" really mean? It took a world war to propel Americans to make a serious commitment to global study. At the dawn of the World War II, the United States was the only allied great power without a formal and central institution to collect global "intelligence," and universities were notoriously deficient in studying parts of the world outside Europe and North America. When Franklin D. Roosevelt recruited William J. (Wild Bill) Donovan in 1941 to be his first coordinator of information, Donovan established the Research and Analysis Branch in Washington, D.C., and started hiring top academics. The fledgling office was reborn as a key unit of the Office of Strategic Services (OSS), itself established a few months after Pearl Harbor. As the United States joined the Allied war effort, Donovan hired several senior, and a great many younger, academics, principally from the Ivy League, to coordinate the collection, sorting, and analysis of material relevant to the war. Although academics were initially recruited by discipline (like history, anthropology, geography, economics, politics), Donovan's "dean" of the OSS, the Harvard historian William L. Langer, soon recognized the need for area-specific interdisciplinary teams. That represented a major departure, as interdisciplinary research was still largely undeveloped in universities in the years before the war. Now, without a world war or a cold war, people have the luxury to move to the global in a more deliberative, engaged, disciplined, and intellectually serious (and less directly politicized) way than when area studies began. The future depends on understanding the new demands of globalization.

Published
2012

50. Clinical phenotypes and prognostic features of embryonal tumours with multi-layered rosettes: a Rare Brain Tumor Registry study

Author

Khan, Sara, Solano-Paez, Palma, Suwal, Tannu, Lu, Mei, Al-Karmi, Salma, Ho, Ben, Mumal, Iqra, Shago, Mary, Hoffman, Lindsey M, Dodgshun, Andrew, Nobusawa, Sumihito, Tabori, Uri, Bartels, Ute, Ziegler, David S, Hansford, Jordan R, Ramaswamy, Vijay, Hawkins, Cynthia, Dufour, Christelle, André, Nicolas, Bouffet, Eric, Huang, Annie, Gonzalez CV, Almeida, Stephens, Derek, Leary, Sarah, Marrano, Paula, Fonseca, Adriana, Thacker, Nirav, Li, Bryan K., Lindsay, Holly B., Lassaletta, Alvaro, Bendel, Anne E., Moertel, Christopher, Morales La Madrid, Andres, Santa-Maria, Vicente, Lavarino, Cinzia, Rivas, Eloy, Perreault, Sebastian, Ellezam, Benjamin, Weil, Alexander G, Jabado, Nada, Oviedo, Angelica, Yalon-Oren, Michal, Amariglio, Laura, Toledano, Helen, Dvir, Rina, Loukides, James, Van Meter, Timothy E., Nakamura, Hideo, Wong, Tai-Tong, Wu, Kuo-Sheng, Cheng, Chien-Jui, Ra, Young-Shin, La Spina, Milena, Massimi, Luca, Buccoliero, Anna Maria, Reddy, Alyssa, Li, Rong, Gillespie, G. Yancey, Adamek, Dariusz, Fangusaro, Jason, Scharnhorst, David, Torkildson, Joseph, Johnston, Donna, Michaud, Jean, LafayCousin, Lucie, Chan, Jennifer, Van Landeghem, Frank, Wilson, Beverly, Camelo-Piragua, Sandra, Kabbara, Nabil, Boutarbouch, Mahjouba, Hanson, Derek, Jacobsen, Chad, Wright, Karen, Vibhakar, Rajeev, Levy, Jean M., Wang, Yin, Catchpoole, Daniel, Gerber, Nicholas, Grotzer, Michael A., Shen, Violet, Plant, Ashley, Dunham, Christopher, Joao Gil da Costa, Maria, Ramanujachar, Ramya, Raabe, Eric, Rubens, Jeffery, Phillips, Joanna, Gupta, Nalin, Demir, Haci Ahmet, Dahl, Christine, Jorgensen, Mette, Hwang, Eugene I., Packer, Roger J, Smith, Amy, Tan, Enrica, Low, Sharon, Lu, Jian-Qiang, Ng, Ho- Keung, Kresak, Jesse L., Gururangan, Sridharan, Pomeroy, Scott L., Sirachainan, Nongnuch, Hongeng, Suradej, Magimairajan, Vanan, Sinha, Roona, Mushtaq, Naureen, Antony, Reuben, Sato, Mariko, Samuel, David, Zapotocky, Michal, Afzal, Samina, Walter, Andrew, Tihan, Tarik, Tsang, Derek S., Gajjar, Amar, Wood, Paul, Cain, Jason E., Downie, Peter A., Gottardo, Nicolas, Branson, Helen, Laughlin, Suzanne, Ertl-Wagner, Birgit, Kulkarni, Abhaya V., Taylor, Michael D., Drake, James, Ibrahim, George M., Dirks, Peter B., Rutka, James T., Somers, Gino R., Hazrati, Lili-Naz, Bourdeaut, Franck, Padovani, Laetitia, Grundy, Richard G., Mazewski, Claire M., and Fouladi, Maryam

Abstract

Embryonal tumours with multi-layered rosettes (ETMRs) are a newly recognised, rare paediatric brain tumour with alterations of the C19MCmicroRNA locus. Due to varied diagnostic practices and scarce clinical data, disease features and determinants of outcomes for these tumours are poorly defined. We did an integrated clinicopathological and molecular analysis of primary ETMRs to define clinical phenotypes, and to identify prognostic factors of survival and key treatment modalities for this orphan disease.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results