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Through our shared interest in articulating a knowledge base for teacher education, we believe a deeper examination of the "work" of teacher educators would contribute to a fuller understanding of who teacher educators are and the work they do. Recognizing how context and positionality influence conceptions of teacher education and with a desire to refine our own understandings of the work of teacher educators, we engaged in a collaborative self-study to examine the work of 12 university-based teacher educators in the United States. Through our analysis of one day in our work, we identified three key functions that transcend our positions and, at the same time, are essential, even core, aspects of the work that we enact daily. These functions of Design, Leadership and Advocacy are all framed by the educative purpose of the work of teacher educators. These functions are overlapping and highlight the movement and energy among the functions and collective purpose for teacher educator work. An underlying thread of connectivity, building and maintaining growth-oriented relationships through positionality, communication, and interaction weaves throughout the functions, and we found our community of practice developed throughout the collaborative self-study was a key aspect of connectivity and collaboration in our work as teacher educators. Identifying the key educative functions across our work enabled us to codify a shared language and challenge the assumption that there is no knowledge base in teacher education as an enterprise. We believe our examination of our work informs future inquiry into collective teacher educator practice.

Introduction To investigate whether biochemical and haematological changes due to the patient’s host response (CoLab algorithm) in combination with a SARS-CoV-2 viability PCR (v-PCR) can be used to determine when a patient with COVID-19 is no longer infectious.We hypothesise that the CoLab algorithm in combination with v-PCR can be used to determine whether or not a patient with COVID-19 is infectious to facilitate the safe release of patients with COVID-19 from isolation.Methods and analysis This study consists of three parts using three different cohorts of patients. All three cohorts contain clinical, vital and laboratory parameters, as well as logistic data related to isolated patients with COVID-19, with a focus on intensive care unit (ICU) stay. The first cohort will be used to develop an algorithm for the course of the biochemical and haematological changes of the host response of the COVID-19 patient. Simultaneously, a second prospective cohort will be used to investigate the algorithm derived in the first cohort, with daily measured laboratory parameters, next to conventional SARS-CoV-2 reverse transcriptase PCRs, as well as v-PCR, to confirm the presence of intact SARS-CoV-2 particles in the patient. Finally, a third multicentre cohort, consisting of retrospectively collected data from patients with COVID-19 admitted to the ICU, will be used to validate the algorithm.Ethics and dissemination This study was approved by the Medical Ethics Committee from Maastricht University Medical Centre+ (cohort I: 2020-1565/300523) and Zuyderland MC (cohorts II and III: METCZ20200057). All patients will be required to provide informed consent. Results from this study will be disseminated via peer-reviewed journals and congress/consortium presentations.

This essay by Dirck Roosevelt and Jim Garrison seeks to reclaim the lost soul of teaching by examining distortions wrought upon or threatening it by practice-based teacher education (PBTE) and like developments. The notion that teaching centers upon mastery of "core" practices understood as routinely skilled performance is inadequate to the almost intractable complexity of teaching. After critiquing PBTE and associated forces, especially the performance assessment edTPA™, Roosevelt and Garrison turn to John Dewey's notion of the teacher as "inspirer and director of soul-life." Among other important attributes involved in forming the soul of inspirational teaching, the authors discuss moral perception of the needs, desires, and interests of unique individuals participating in specific situations, and also moral imagination, which allows teachers to see beyond the actual to conceive better possibilities. Roosevelt and Garrison conclude with depictions of two student-teachers, one troubled by her inability to hear the souls of students and another experiencing the loss of his teaching soul.

Over the last half-century, the world’s human population has doubled, impacting almost all ocean and land areas. The threats facing primates in the wild have never been greater or more complex. Primatologists have long been aware of these threats and, since the 1970s, have coordinated efforts to safeguard these threatened species, through the International Union for Conservation of Nature Species Survival Commission (IUCN SSC) Primate Specialist Group (PSG). In an effort to stem the threat of extinction to primates, this group of now 700 experts+ has published 17 conservation action plans since 1977. As we look toward the next half-century, we take stock of the history of primate action planning to better understand the costs and benefits of these plans as a conservation tool. Here, we reviewed all plans published by the IUCN SSC PSG. In total, they described USD 246 million in planned primate conservation programming and were cited 1657 times by others. We found that half of the plans had been assessed in regard to their implementation, although these assessments were not standardized. Those that had been assessed, showed evidence of positive impacts on awareness raising, collaboration, fundraising, project implementation and policy, although the impact varied by plan. For example, three of the plans directly resulted in USD 15.92 million in funds raised; four plans quantified implementation rates, which ranged from 38% to 74% of actions partially or completely achieved 5 years after plan publication; and four plans attributed the gazettement of 19 protected areas across 11 countries as indirect successes following the publication of plans. Considered together, we reflect on the ‘return-on-investment’ for developing these plans and consider a range of ‘lessons learned’ for future primate action planning efforts.

Road weather conditions such as ice, snow, or heavy rain can have a significant impact on driver safety. In this paper, we present an approach to continuously monitor the road conditions in real time by equipping a fleet of vehicles with sensors. Based on the observed conditions, a physical road weather model is used to forecast the conditions for the following hours. This can be used to deliver timely warnings to drivers about potentially dangerous road conditions. To optimally process the large data volumes, we show how artificial intelligence is used to (1) calibrate the sensor measurements and (2) to retrieve relevant weather information from camera images. The output of the road weather model is compared to forecasts at road weather station locations to validate the approach.

Los policultivos juegan un papel importante en la biodiversidad de un agroecosistema, estos promueven servicios ecológicos tales como reciclaje de nutrientes, control biológico de plagas, enfermedades y arvenses, incremento en la producción de biomasa, conservación de suelos y agua, mejoramiento de calidad físico-química del suelo, reducción de la toxicidad al evitar o disminuir el uso de pesticidas. El estudio se realizó en el municipio Tisma, Masaya en la finca “El Chagüite” en los meses de Septiembre a Noviembre del 2014, con el objetivo de estudiar el efecto de dos sistemas de siembra, cultivo puro y policultivo, sobre la ocurrencia poblacional de artrópodos plagas y benéficos e incidencia poblacional del ataque del ácaro blanco en el cultivo de chiltoma. Para el desarrollo de la investigación se establecieron cuatro parcelas, una con el arreglo en policultivos (chiltoma, maíz, tomate, yuca y quequisque) y los restantes se establecieron con cultivo puro de chiltoma, maíz y tomate. Las variables evaluadas semanalmente fueron la ocurrencia poblacional de artrópodos plagas y benéficos, ocurrencia del ácaro blanco y el rendimiento obtenido en los cultivos de chiltoma, maíz y tomate para el análisis del uso equivalente de la tierra (UET). En general se observó una tendencia de menor ocurrencia de plagas, menor densidad poblacional de ácaro blanco, mayor densidad poblacional de artrópodos benéficos y un mejor aprovechamiento de la tierra por unidad de área en el sistema de siembra de policultivo.

Human cytomegalovirus (HCMV) is a species-specific virus that establishes a persistent/latent infection in CD34+ hematopoietic progenitor cells (HPCs). The ability of HCMV to reactivate from latency is exquisitely linked to changes in cell signaling, which result in HPC differentiation. The Wnt/β-catenin pathway is tightly linked to CD34+ HPC homeostasis and differentiation. The majority of the viral and cellular factors involved in the maintenance of HCMV latency and reactivation are still unknown. Our group previously discovered a viral hematopoietic cytokine (pUL7) that promotes cellular differentiation and viral reactivation. Here, we show that the UL7-related RL11 family member UL8 is also required for efficient viral reactivation in CD34+ HPCs by interacting with components of the (Wnt)/β-catenin pathway. Pull-down experiments demonstrate that UL8 and β-catenin interact with Dishevelled-2 (DVL2) through their PDZ-binding domains, and this interaction promotes β-catenin stabilization and transcriptional activation. Disrupting the interaction among UL8, β-catenin, and DVL2 blocks HCMV reactivation in vitro and in vivo, similar to deletion of UL8. This is the first observation that Wnt signaling components are essential for HCMV reactivation, unlike α- and γ-herpesvirus that require an active Wnt pathway to maintain latency. Detailed understanding of how the Wnt network is manipulated by herpesviruses will improve our ability to develop targeted therapeutics. IMPORTANCE CD34+ hematopoietic progenitor cells (HPCs) are an important cellular reservoir for latent human cytomegalovirus (HCMV). Several HCMV genes are expressed during latency that are involved with the maintenance of the viral genome in CD34+ HPC. However, little is known about the process of viral reactivation in these cells. Here, we describe a viral protein, pUL8, and its interaction and stabilization with members of the Wnt/β-catenin pathway as an important component of viral reactivation. We further define that pUL8 and β-catenin interact with DVL2 via a PDZ-binding domain, and loss of UL8 interaction with β-catenin-DVL2 restricts viral reactivation. Our findings will be instrumental in understanding the molecular processes involved in HCMV reactivation in order to design new antiviral therapeutics. [ABSTRACT FROM AUTHOR]