265 results on '"Dipen Shah"'
Search Results
2. The significance of pulmonary veins isolation radiofrequency time and the evolution of left atrium volume on a twelve-year observational follow-up of paroxysmal atrial fibrillation patients
- Author
-
Eric Buffle, Nicolas Johner, Mehdi Namdar, and Dipen Shah
- Subjects
Paroxysmal atrial fibrillation ,Pulmonary veins ,Ablation ,Radiofrequency ,Reintervention ,Predictors ,Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Aims: Pulmonary vein isolation (PVI) is the treatment of choice of paroxysmal atrial fibrillation (PAF). However, radiofrequency delivery at extra-PV sites may be additionally required. We compared clinical and procedural characteristics of patients undergoing PVI alone versus adjunctive extra-PV substrate modification, at first procedure and repeat procedures for AF recurrence. Methods: 587 patients with PAF undergoing radiofrequency (RF) ablation were retrospectively included. Extra-PV ablation was performed in case of sustained AF despite PVI, or at re-do procedures without PV conduction recovery. Demographic, clinical and electrophysiological predictors of survival without re-intervention were analysed in patients’ groups having undergone one (G1), two (G2) or three or more procedures (G3). Results: At baseline procedure, PV RF ablation time was shorter in G1 compared to G2/G3 whereas extra-PV RF ablation time was greater in G3 compared to G1. The proportion of patients requiring PV re-isolation decreased with repeat procedures. Smaller LA before procedure 1 (p1) or p2 was associated with PV reconnection at p2. Conversely larger LA before p1 was associated with extra-PV substrate modification at p2. Late re-do procedure timing (>1yr) was associated with increasing LA volume. Only longer PV and total RF time predicted poorer survival free from AF without re-intervention. Conclusion: Longer PV RF time predicted requirement for re-ablation during follow-up. Smaller LA size predicted an increased probability of PV reconnection and decreased extra-PV substrate modification at p2. LA size decreased in patients undergoing early re-intervention, whereas it increased in patients undergoing re-intervention later on suggesting ongoing remodelling or progression.
- Published
- 2022
- Full Text
- View/download PDF
3. Long-term risk of adverse outcomes according to atrial fibrillation type
- Author
-
Steffen Blum, Stefanie Aeschbacher, Michael Coslovsky, Pascal B. Meyre, Philipp Reddiess, Peter Ammann, Paul Erne, Giorgio Moschovitis, Marcello Di Valentino, Dipen Shah, Jürg Schläpfer, Rahel Müller, Jürg H. Beer, Richard Kobza, Leo H. Bonati, Elisavet Moutzouri, Nicolas Rodondi, Christine Meyer-Zürn, Michael Kühne, Christian Sticherling, Stefan Osswald, David Conen, and the BEAT-AF and Swiss-AF investigators
- Subjects
Medicine ,Science - Abstract
Abstract Sustained forms of atrial fibrillation (AF) may be associated with a higher risk of adverse outcomes, but few if any long-term studies took into account changes of AF type and co-morbidities over time. We prospectively followed 3843 AF patients and collected information on AF type and co-morbidities during yearly follow-ups. The primary outcome was a composite of stroke or systemic embolism (SE). Secondary outcomes included myocardial infarction, hospitalization for congestive heart failure (CHF), bleeding and all-cause mortality. Multivariable adjusted Cox proportional hazards models with time-varying covariates were used to compare hazard ratios (HR) according to AF type. At baseline 1895 (49%), 1046 (27%) and 902 (24%) patients had paroxysmal, persistent and permanent AF and 3234 (84%) were anticoagulated. After a median (IQR) follow-up of 3.0 (1.9; 4.2) years, the incidence of stroke/SE was 1.0 per 100 patient-years. The incidence of myocardial infarction, CHF, bleeding and all-cause mortality was 0.7, 3.0, 2.9 and 2.7 per 100 patient-years, respectively. The multivariable adjusted (a) HRs (95% confidence interval) for stroke/SE were 1.13 (0.69; 1.85) and 1.27 (0.83; 1.95) for time-updated persistent and permanent AF, respectively. The corresponding aHRs were 1.23 (0.89, 1.69) and 1.45 (1.12; 1.87) for all-cause mortality, 1.34 (1.00; 1.80) and 1.30 (1.01; 1.67) for CHF, 0.91 (0.48; 1.72) and 0.95 (0.56; 1.59) for myocardial infarction, and 0.89 (0.70; 1.14) and 1.00 (0.81; 1.24) for bleeding. In this large prospective cohort of AF patients, time-updated AF type was not associated with incident stroke/SE.
- Published
- 2022
- Full Text
- View/download PDF
4. ECMELLA as a bridge to heart transplantation in refractory ventricular fibrillation: A case report
- Author
-
Raphaël Giraud, Benjamin Assouline, Haran Burri, Dipen Shah, Philippe Meyer, Sophie Degrauwe, Matthias Kirsch, and Karim Bendjelid
- Subjects
VA-ECMO ,Impella ,ECMELLA ,cardiac arrest ,refractory ventricular fibrillation ,heart transplantation ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundExtracorporeal membrane oxygenation (ECMO) is an effective cardiorespiratory support technique in refractory cardiac arrest (CA). In patients under veno-arterial ECMO, the use of an Impella device, a microaxial pump inserted percutaneously, is a valuable strategy through a left ventricular unloading approach. ECMELLA, a combination of ECMO with Impella, seems to be a promising method to support end-organ perfusion while unloading the left ventricle.Case summaryThe present case report describes the clinical course of a patient with ischemic and dilated cardiomyopathy who presented with refractory ventricular fibrillation (VF) leading to CA in the late postmyocardial infarction (MI) period, and who was successfully treated with ECMO and IMPELLA as a bridge to heart transplantation.DiscussionIn the case of CA on VF refractory to conventional resuscitation maneuvers, early extracorporeal cardiopulmonary resuscitation (ECPR) associated with an Impella seems to be the best strategy. It provides organ perfusion, left ventricular unloading, and ability for neurological evaluation and VF catheter ablation before allowing heart transplantation. It is the treatment of choice in cases of end-stage ischaemic cardiomyopathy and recurrent malignant arrhythmias.
- Published
- 2023
- Full Text
- View/download PDF
5. Sex differences of vascular brain lesions in patients with atrial fibrillation
- Author
-
Christian Müller, Leo H Bonati, Pascal Meyre, Steffen Blum, Stefanie Aeschbacher, David Conen, Stefan Osswald, Urs Fischer, Manuel R Blum, Simon Jung, Jens Wuerfel, Christian Sticherling, Michael Kuhne, Philipp Krisai, Matthias Schwenkglenks, Luise Adam, Elisavet Moutzouri, Martin Feller, Nathalie Schwab, Claudio Schneider, Drahomir Aujesky, Nicolas Rodondi, Karl-Olof Lovblad, Michael Amann, Richard Kobza, Marie Méan, Andreas Müller, Giorgio Moschovitis, Fabienne Witassek, Silke Küest, Sonja Meier, Jürg-Hans Beer, Damiana Rakovic, Michael Coslovsky, Tiziano Moccetti, Ramun Schmid, Augusto Gallino, Carole Elodie Aubert, Georg Ehret, Angelo Auricchio, Giulio Conte, Daniel Hayoz, Benjamin Berte, Nathalie Lauriers, Peter Ammann, François Regoli, Dipen Shah, Laurent Roten, Marco Düring, Pascal Benkert, Simone Evers-Dörpfeld, Elisa Hennings, Ceylan Eken, Selinda Ceylan, Anne Springer, Heinrich Mattle, Tim Sinnecker, Leo Bonati, Anna Altermatt, Manuel Blum, Sacha Niederberger, Chloé Auberson, Simone Evers-Doerpfeld, Marc Girod, Elena Herber, Vasco Iten, Mirko Lischer, Christine Meyer-Zürn, Andreas U Monsch, Thomas Szucs, Gian Völlmin, Juerg Fuhrer, Axel Loewe, Tanja Flückiger, Cindy Groen, Lukas Ehrsam, Sven Hellrigl, Alexandra Nuoffer, Rylana Wenger, Christopher Beynon, Roger Dillier, Michèle Deubelbeiss, Franz Eberli, Christine Franzini, Isabel Juchli, Claudia Liedtke, Jacqueline Nadler, Thayze Obst, Jasmin Roth, Fiona Schlomowitsch, Xiaoye Schneider, Katrin Studerus, Noreen Tynan, Dominik Weishaupt, Simone Fontana, Karin Scheuch, Denise Hischier, Nicole Bonetti, Alexandra Grau, Jonas Villinger, Eva Laube, Philipp Baumgartner, Mark Filipovic, Marcel Frick, Giulia Montrasio, Stefanie Leuenberger, Franziska Rutz, Adriana Anesini, Cristina Camporini, Maria Luce Caputo, Roman Brenner, David Altmann, Michaela Gemperle, Mathieu Firmann, Sandrine Foucras, Martine Rime, Virgina Justi, Frauke Kellner-Weldon, Brigitta Mehmann, Myriam Roth, Andrea Ruckli-Kaeppeli, Ian Russi, Kai Schmidt, Mabelle Young, Melanie Zbinden, Luisa Vicari, Hervé Gallet, Elise Guillermet, Francois Lazeyras, Patrick Perret, Philippe Tavel, Cheryl Teres, Sandrine Salzmann, Jürg Schläpfer, Andrea Grêt, Jan Novak, Sandra Vitelli, Frank-Peter Stephan, Jane Frangi-Kultalahti, Marcello Di Valentino, Jens Würfel, Petra Huber, Esther Ruberte, Vanessa Zuber, Gilles Dutilh, Milica Markovic, Pia Neuschwander, and Patrick Simon
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objective To examine sex differences in prevalence, volume and distribution of vascular brain lesions on MRI among patients with atrial fibrillation (AF).Methods In this cross-sectional analysis, we included 1743 patients with AF (27% women) from the multicentre Swiss Atrial Fibrillation study (SWISS-AF) with available baseline brain MRI. We compared presence and total volume of large non-cortical or cortical infarcts (LNCCIs), small non-cortical infarcts, microbleeds (MB) and white matter hyperintensities (WMH, Fazekas score ≥2 for moderate or severe degree) between men and women with multivariable logistic regression. We generated voxel-based probability maps to assess the anatomical distribution of lesions.Results We found no strong evidence for an association of female sex with the prevalence of all ischaemic infarcts (LNCCI and SNCI combined; adjusted OR 0.86, 95% CI 0.67 to 1.09, p=0.22), MB (adjusted OR 0.91, 95% CI 0.68 to 1.21, p=0.52) and moderate or severe WMH (adjusted OR 1.15, 95% CI 0.90 to 1.48, p=0.27). However, total WMH volume was 17% larger among women than men (multivariable adjusted multiplicative effect 1.17, 95% CI 1.01 to 1.35; p=0.04). Lesion probability maps showed a right hemispheric preponderance of ischaemic infarcts in both men and women, while WMH were distributed symmetrically.Conclusion Women had higher white matter disease burden than men, while volume and prevalence of other lesions did not differ. Our findings highlight the importance of controlling risk factors for cerebral small vessel disease in patients with AF, especially among women.
- Published
- 2022
- Full Text
- View/download PDF
6. Association of body mass index with outcomes in patients with newly diagnosed atrial fibrillation: GARFIELD-AF
- Author
-
Daniela Poli, Sophie Testa, Corrado Lodigiani, Toon Wei Lim, Kevin Jones, Kangning Chen, Hui Li, Hilary Pinnock, Grzegorz Bilo, Hack-Lyoung Kim, Andrew Murray, Bernard J Gersh, Kurt Huber, Robin Fox, Sarah Davies, James Rogers, Morten Schou, Xin Li, Vira Tseluyko, Sergey Popov, Rajeev Gupta, Grzegorz Opolski, Preeti Pandya, Bronte Ayres, Milan Gupta, Peter Hutchinson, Phil Simmons, Andrew Gallagher, Michel Galinier, Franck Paganelli, Jens Kilian, Adam Blenkhorn, Mohamed Ibrahim, Fernando Lanas, Karen Pieper, Eivind Berge, M Clark, Agneta Andersson, Karim Ladha, Bijoy Sinha, Torstein Hole, Dan Atar, Hywel Jones, R Smith, Andrew Ross, Emmanuel Ellie, Paul Evans, Yong Wang, Hiroshi Ono, Tadashi Nakamura, Paul MacDonald, Stephen Rogers, Igor Sibon, Simon Dobson, David Fitzmaurice, Jiyan Chen, Neil Roberts, Pierre Amarenco, Nigel Hart, Giancarlo Agnelli, Georges Mairesse, Pekka Raatikainen, Oleg Sychov, Yasuyuki Suzuki, Bo Liu, Mathieu Zuber, John French, Yuejin Yang, Myeong-Chan Cho, Julian Thompson, Michael Stokes, John W Eikelboom, Mark Richardson, John Matthews, Will Murdoch, Jean-Philippe Neau, Freek Verheugt, Ajay K Kakkar, Giuseppe Ambrosio, Marcin Gruchała, Keith A A Fox, Sunil Kumar, Ruiping Zhao, Patrick Carroll, Masanori Kaneko, Thanh Phan, Ping Yang, Sung-Won Jang, Claire Jones, Mårten Rosenqvist, Johan Engdahl, Debabrata Roy, John Cairns, Ping Chen, Michael Olsen, Paul Angaran, David Russell, Helena Dominguez, Béla Merkely, Joseph Berlingieri, James Bennett, Hugo ten Cate, Hiroshi Yamaguchi, Masahiro Minamoto, Hiroyuki Oda, Toshihiko Shiraiwa, Jonathan Webster, Yukihiro Koretsune, Kotaro Obunai, R Thompson, Yong Seog Oh, Giuliana Guazzaloca, Giuliana Martini, Marc Bonnefoy, Michael Cox, András Nagy, Kazuki Sato, Richard Davies, Daisuke Ikeda, Susumu Suzuki, Hiroki Teragawa, Koji Matsushita, Ying Guo, Catherine Neden, Mark Pugsley, Simon Cartwright, Polly Jacobs, Xiaoshu Cheng, Daniel Nishijima, Sylvia Haas, Vinay Kumar, Saverio Virdone, Jean-Pierre Bassand, Samuel Z Goldhaber, Shinya Goto, Frank Misselwitz, Alexander G G Turpie, Alison Macleod, Karen Forshaw, Mark Boon, Stephen Miller, Simon Wetherell, Moustafa Moustafa, Gaetano Serviddio, Renato Lopes, Kazuo Takei, Hiroaki Nishioka, Mykola Stanislavchuk, C Ramesh, R Kamath, Stuart J Connolly, Nooshin Bazargani, Kevin Douglas, Werner Hacke, Gloria Kayani, Ali Oto, Hiroshi Watanabe, Walter Hermans, Kazuya Murata, Christian Fielder Camm, Marco Moia, Niraj Sharma, Jaeyoung Kim, Walter Abhayaratna, Andriy Yagensky, Hosen Kiat, Wilhelm Haverkamp, Yang Jiao, Hitoshi Kato, Jindrich Spinar, Daniel Theodoro, Philip Cooke, Paolo Golino, Tetsuro Yoshida, Prakash Chandwani, Christine A'Court, Brian Ramjattan, Torbjørn Øien, Toshiyuki Kobayashi, Richard West, Petr Jansky, Seil Oh, Jan Steffel, Martin van Eickels, Hyung-Wook Park, Nam-Ho Kim, Søren Rasmussen, Kazuo Suzuki, David Colquhoun, Hiroshi Ando, Simon Franklin, Tae-Joon Cha, Sang Cheol Bae, Guosheng Fu, Yoshihiro Saito, Heinz Drexel, Michel Martelet, Joseph Mouallem, Nicolas Delarche, Sylvain Destrac, Neil Macey, Andreas Kopf, Masayuki Nakano, Olga Barbarash, Takeshi Inoue, Taro Minagawa, Weihua Li, John Eikelboom, Hiroshi Kubo, Lars Andersson, D Burns, Andrea Podczeck-Schweighofer, Megumi Okada, Massimo Volpe, Takuma Aoyama, Karsten Mueller, Carlos Astudillo, Hiroshi Takeda, Peter Mayer, Jung Hoon Sung, Dinesh Jain, Jung Han Yoon, Alessandro Capucci, Dongryeol Ryu, Kelvin Wong, Hong Euy Lim, Xiaowei Yan, Yusheng Zhao, Yuehui Yin, YUKIHIRO SETA, Taek Jong Hong, MASAKI SHIMOYAMA, Dayi Hu, Junichi Minami, Yuriy Mostovoy, David Foo, Ramazan Topsakal, Zhi-Cheng Jing, Dipen Shah, Kenichi Yamamoto, David Coulshed, Olivier Piot, Ramón Corbalán, Silva Severi, Waldemar Myszka, Mehmet Birhan Yilmaz, Gi-Byoung Nam, Jun Kim, Harald Darius, Jan-Erik Karlsson, PETER VANDERGOTEN, Nasser Taha, Shuta Toru, Jörn Nielsen, Tsutomu Takagi, Koji Higuchi, Steen Husted, Tomohiro Katsuya, Frank Cools, Iveta Petrova, Songkwan Silaruks, GÜNTER LEHMANN, Frederic Casassus, Bernard Crousillat, Bernard Doucet, Jean-Joseph Muller, Grzegorz Raczak, Kazuyuki Saito, Anders Ostrem, Chi Keong Ching, KUNIHIKO YAMAMOTO, John Camm, Carmine Mazzone, Jaemin Shim, Jadwiga Nessler, Jan Vercammen, Marc Delforge, Chong-Jin Kim, Pierre Nazeyrollas, Louise Lumley, Paul Roome, Helen Stoddart, Mark Rickenbach, Paul Mullen, Noriyuki Nakanishi, Gordon Irvine, Paul Conn, Kurt Lenz, Richard Coates, E Fisher, Warwick Coulson, Jiri Lastuvka, Pablo García Pavía, P Jhittay, Philip Saunders, Peter Bernhardt, Wanwarang Wongcharoen, Kentaro Yamamoto, Hector Lucas Luciardi, Harry Gibbs, Marianne Brodmann, Jørn Dalsgaard Nielsen, Hany Ragy, Matyas Keltai, Jitendra Pal Singh Sawhney, Janina Stepinska, Elizaveta Panchenko, Barry Jacobson, Xavier Viñolas, Pantep Angchaisuksiri, Alex Parkhomenko, Huaiqin Zhang, Shiping Cao, Daowen Wang, Guizhou Tao, Yingmin Chen, Shenghu He, Tongguo Wu, Moshui Chen, Longgen Xiong, Praveen Jadhavm, Raghava Sarma, Govind Kulkarni, Rasesh Atulbhai Pothiwala, Mohanan Padinhare Purayil, Kamaldeep Chawla, Veerappa Annasaheb Kothiwale, Bagirath Raghuraman, Vinod Madan Vijan, Jitendra Sawhney, Ganapathi Bantwal, Aziz Khan, Ramdhan Meena, Manojkumar Chopada, Sunitha Abraham, Vikas Bisne, Govindan Vijayaraghavan, Rajashekhar Durgaprasad, Kartikeya Bhargava, Udigala Madappa Nagamalesh, Rajeeve Kumar Rajput, Seishu Kanamori, Koichiro Kumagai, Yosuke Katsuda, Keiki Yoshida, Fumitoshi Toyota, Yuji Mizuno, Ikuo Misumi, Hiroo Noguchi, Shinichi Ando, Tetsuro Suetsugu, Susumu Adachi, Kei Chiba, Hiroaki Norita, Makoto Tsuruta, Takeshi Koyanagi, Takayuki Higashi, Shiro Azakami, Shinichiro Komaki, Kenshi Kumeda, Takashi Murayama, Jun Matsumura, Yurika Oba, Ryuji Sonoda, Kazuo Goto, Kotaro Minoda, Yoshikuni Haraguchi, Hisakazu Suefuji, Hiroo Miyagi, Tsugihiro Nakamura, Hidekazu Nandate, Ryuji Zaitsu, Yoshihisa Fujiura, Akira Yoshimura, Hiroyuki Numata, Jun Ogawa, Yasuyuki Kamogawa, Kinshiro Murakami, Yutaka Wakasa, Masanori Yamasawa, Hiromitsu Maekawa, Sumihisa Abe, Hajime Kihara, Satoru Tsunoda, Katsumi Saito, Hiroki Tachibana, Ichiro Oba, Takashi Kuwahata, Satoshi Higa, Masamichi Gushiken, Takuma Eto, Hidetoshi Chibana, Kazuaki Fujisawa, Yuhei Shiga, Hirokuni Sumi, Toshihisa Nagatomo, Yoshihiko Atsuchi, Toshiro Nagoshi, Kazuhisa Sanno, Fumihiro Hoshino, Naoto Yokota, Masahiro Kameko, Toshifumi Tabuchi, Munesumi Ishizawa, Yoshitake Fujiura, Taku Seto, Tetsu Iwao, Norio Ishioka, Koichi Oshiro, Keizo Tsuchida, Yutaka Hatori, Motoshi Takeuchi, Hiroto Takezawa, Shinjiro Nagano, Masaaki Iwaki, Yuichiro Nakamura, Naomasa Miyamoto, Toshifumi Taguchi, Ko Ashida, Naoto Yoshizawa, Jun Agata, Seishiro Matsukawa, Osamu Arasaki, Shuji Fukuoka, Hirofumi Murakami, Kazuya Mishima, Yoshiki Hata, Ichiro Sakuma, Ichiro Takamura, Mitsuyuki Akutsu, Toshihide Unoki, Yoshinori Go, Makoto Ikemura, Shoji Morii, Shigeru Marusaki, Hideo Doi, Mitsuru Tanaka, Takaaki Kusumoto, Shigeo Kakinoki, Chiga Ogurusu, Masami Nakatsuka, Yutaka Kitami, Yoichi Nakamura, Hiroshi Oda, Rikimaru Oyama, Masato Ageta, Teruaki Mita, Kazuhiko Nagao, Takafumi Mito, Mitsunori Abe, Masako Fujii, Makoto Okawa, Tsuneo Fujito, Toshiya Taniguchi, Tenei Ko, Mizuho Imamaki, Masahiro Akiyama, Takashi Ueda, Hironori Odakura, Masahiko Inagaki, Yoshiki Katsube, Atsuyuki Nakata, Shinobu Tomimoto, Mitsuhiro Shibuya, Kenichiro Ito, Masahiro Matsuta, Motoyuki Ishiguro, Masamichi Wada, Hiroaki Mukawa, Masato Mizuguchi, Fumio Okuda, Teruaki Kimura, Kuniaki Taga, Masaaki Techigawara, Morio Igarashi, Toshihiko Seo, Shinya Hiramitsu, Hiroaki Hosokawa, Mitsumoto Hoshiai, Michitaka Hibino, Koichi Miyagawa, Hideki Horie, Nobuyoshi Sugishita, Yukio Shiga, Akira Soma, Kazuo Neya, Kunio Akahane, Saori Matsui, Hirofumi Kanda, Shiro Nagasaka, Atsushi Taguchi, Akiko Miyashita, Hiroki Sasaguri, Jin Nariyama, Taketo Hatsuno, Takash Iwase, Kazuya Kawai, Tomobumi Kotani, Tsuyoshi Tsuji, Hirosumi Sakai, Kiyoshi Nishino, Kenichi Ikeda, Kazuo Maeda, Tomohiro Shinozuka, Koichi Kawakami, Hiromichi Kitazumi, Mamoru Hamaoka, Jisho Kojima, Akitoshi Sasaki, Yoshihiro Tsuchiya, Tetsuo Betsuyaku, Masaaki Honda, Koichi Hasegawa, Takao Baba, Kazuaki Mineoi, Toshihiko Koeda, Kunihiko Hirasawa, Toshihide Kumazaki, Akira Nakagomi, Eiji Otaki, Takashi Shindo, Hiroyoshi Hirayama, Chikako Sugimoto, Takashi Yamagishi, Ichiro Mizuguchi, Kazunori Sezaki, Isamu Niwa, Ken Takenaka, Osamu Iiji, Koichi Taya, Hitoshi Kitazawa, Samu Ueda, Hirokazu Kakuda, Takuya Ono, Seizo Oriso, Junya Kamata, Toshihiko Nanke, Itaru Maeda, Yoshifusa Matsuura, Yasuyuki Maruyama, Hajime Horie, Tetsutaro Kito, Hiroshi Asano, Masaichi Nakamura, Takashi Washizuka, Tomoki Yoshida, Masato Sawano, Shinichi Arima, Hidekazu Arai, Hisanori Shinohara, Hiroyuki Takai, Nobufusa Furukawa, Akira Ota, Kenji Aoki, Taku Yamamoto, Takeaki Kasai, Shunji Suzuki, Shu Suzuki, Nitaro Shibata, Masayuki Watanabe, Yosuke Nishihata, Toru Arino, Masaki Okuyama, Tetsushi Wakiyama, Tomoko Kato, Yasuo Sasagawa, Takeshi Tana, Yoshihito Hayashi, Shinichi Hirota, Yukihiko Abe, Hirohide Uchiyama, Shuichi Tohyo, Naoto Hanazono, Seiichi Miyajima, Hisashi Shimono, Yasunobu Shozawa, Yawara Niijima, Osamu Murai, Hideko Inaba, Katsumasa Nomura, Masatsugu Nozoe, Toshiyuki Furukawa, Nobuhisa Ito, Shunichi Nagai, Kiyoharu Sato, Shiro Nakahara, Yujin Shimoyama, Naoko Ohara, Teruhiko Kozuka, Hideaki Okita, Masato Endo, Tsutomu Goto, Makoto Hirose, Emiko Nagata, Toshizumi Mori, Shuichi Seki, Katsuhiro Okamoto, Osamu Moriai, Yoko Emura, Tsuyoshi Fukuda, Haruhiko Date, Shuichi Kawakami, Sho Nagai, Yuya Ueyama, Tetsuro Fudo, Mitsuru Imaizumi, Takuo Ogawa, Shunsuke Take, Hideo Ikeda, Norihiko Sakamoto, Kiyomitsu Ikeoka, Nobuo Wakaki, Masatake Abe, Junji Doiuchi, Tetsuya Kira, Masato Tada, Ken Tsuzaki, Naoya Miura, Yasuaki Fujisawa, Wataru Furumoto, Akinori Fujisawa, Ryosai Nakamura, Hiroyasu Komatsu, Rei Fujiki, Shuichi Kawano, Keijiro Nishizawa, Yoji Kato, Junya Azuma, Kiyoshi Yasui, Toshio Amano, Yasuhiro Sekine, Tatsuo Honzawa, Yuichiro Koshibu, Yasuhide Sakamoto, Shingo Miyaguchi, Kojuro Morishita, Yasuko Samejima, Toyoshi Sasaki, Fumiko Iseki, Hiroshi Kano, Yoichi Takagi, Yoko Onuki Pearce, Takayuki Fukui, Toru Nakayama, Hideaki Kanai, Yoshiyuki Kawano, Tetsuji Ino, Hironori Miyoshi, Yasufumi Miyamoto, Masahito Shigekiyo, Shimato Ono, Yutaka Okamoto, Satoshi Ubukata, Kojiro Kodera, Tatsuo Oriuchi, Naoki Matsumoto, Koichi Inagaki, Atsushi Iseki, Tomohiro Yoshida, Toshihiro Goda, Tsukasa Katsuki, Atsushi Sato, Etsuo Mori, Toshio Tsubokura, Hiroshi Shudo, Shunichi Fujimoto, Yoshiyuki Furukawa, Hiroshi Hosokawa, Jun Narumi, Kiichiro Yamamoto, Masaki Owari, Takuya Inakura, Takafumi Anno, Kazuyuki Shirakawa, Tan Yuyang, Hui Nam Park, Woo-Shik Kim, HyeYoung Lee, Dae Hyeok Kim, Dae-Kyeong Kim, Dong Ju Choi, Hui-Kyung Jeon, Dong-Gu Shin, Sang Weon Park, Hoon Ki Park, Sang-Jin Han, Young Keun On, JaeJin Kwak, Seong Hoon Park, Kee-Sik Kim, Byung Chun Jung, Gyo-Seung Hwang, Sakda Rungaramsin, Peerapat Katekangplu, Porames Khunrong, Thanita Bunyapipat, Pinij Kaewsuwanna, Khanchai Siriwattana, Waraporn Tiyanon, Supalerk Pattanaprichakul, Khanchit Likittanasombat, Doungrat Cholsaringkarl, Warangkana Boonyapisit, Sirichai Cheewatanakornkul, Pisit Hutayanon, Seksan Chawanadelert, Pairoj Chattranukulchai, Boonsert Chatlaong, Yingsak Santanakorn, Khompiya Kanokphatcharakun, Piya Mongkolwongroj, Sasivimon Jai-Aue, Ongkarn Komson, Armagan Altun, Ali Aydinlar, Zeki Ongen, Sadik Acikel, Durmus Yildiray Sahin, Ozcan Yilmaz, Hasan Pekdemir, Mesut Demir, Murat Sucu, Levent Sahiner, Murat Ersanli, Ertugrul Okuyan, Dursun Aras, Florencia Rolandi, Adrian Cesar Ingaramo, Gustavo Alberto Sambadaro, Vanina Fernandez Caputi, Hector Luciardi, Sofia Graciela Berman, Pablo Dragotto, Andres Javier Kleiban, Nestor Centurion, Ricardo Dario Dran, Javier Egido, Matias Jose Fosco, Victor Alfredo Sinisi, Luis Rodolfo Cartasegna, Oscar Gomez Vilamajo, Jose Luis Ramos, Sonia Sassone, Gerardo Zapata, Diego Conde, Guillermo Giacomi, Alberto Alfredo Fernandez, Mario Alberto Berli, Fabian Ferroni, Jefferson Jaber, Luciana Vidal Armaganijan, André Steffens, José Márcio Ribeiro, Marcelo Silveira Teixeira, Paulo Rossi, Leonardo Pires, Daniel Moreira, Luiz Bodanese, Marcelo Westerlund Montera, Jamil Abdalla Saad, Euler Roberto Manenti, Alexandre Negri, Carlos Moncada, Dalton Precoma, Fernando Roquette, Gilmar Reis, Estêvão Lanna Figueiredo, Roberto Vieira Botelho, Helius Carlos Finimundi, Adriano Kochi, Fábio Alban, Rogério Tadeu Tumelero, Lilia Maia, Humberto Montecinos, Martín Larico Gómez, Carlos Conejeros, Patricio Marin Cuevas, Alejandro Forero, Claudio Bugueño Gutiérrez, Juan Aguilar, Sergio Potthoff Cardenas, German Eggers, Cesar Houzvic, Carlos Rey, Germán Arriagada, Gustavo Charme Vilches, Raul Leal Cantu, Ricardo Cabrera Jardines, Nilda Espinola Zavaleta, Enrique Lopez Rosas, Gerardo Pozas, Ernesto Cardona Muñoz, Norberto Matadamas Hernandez, Adolfo Leyva Rendon, Norberto Garcia Hernandez, David Lopez Villezca, Carlos Hernandez Herrera, Rodolfo Gaona Rodriguez, Efrain Villeda Espinosa, David Flores Martinez, Jose Velasco Barcena, Omar Fierro Fierro, Ignacio Rodriguez Briones, Humberto Alvarez Lopez, Rafael Olvera Ruiz, Roxana Reyes Sanchez, Roberto Arriaga Nava, Pedro Fajardo Campos, Mario Benavides Gonzalez, Claus Hagn, Johannes Foechterle, Michael Winkler, Bruno Schneeweiss, Alfons Gegenhuber, Wilfried Lang, Sabine Eichinger-Hasenauer, Peter Kaserer, Josef Sykora, Heribert Rasch, Bernhard Strohmer, Luc Capiau, Geert Vervoort, Bart Wollaert, Geert Hollanders, Dirk Faes, Yohan Balthazar, Olivier Xhaet, Harry Striekwold, John Thoeng, Kurt Hermans, Wim Anné, Ivan Blankoff, Michel Beutels, Stefan Verstraete, Philippe Purnode, Pascal Godart, Tim Boussy, Philippe Desfontaines, Alex Heyse, Joeri Voet, Eva Zidkova, Rudolf Spacek, Vilma Machova, Ondrej Ludka, Josef Olsr, Lubos Kotik, Blazej Racz, Richard Ferkl, Jan Hubac, Ilja Kotik, Zdenek Monhart, Hana Burianova, Ondrej Jerabek, Jana Pisova, Vratislav Dedek, Michaela Honkova, Petr Podrazil, Petr Reichert, Miroslav Novak, Vaclav Durdil, Katarina Plocova, Ulrik Hintze, Næstved Sygehus, Arne Bremmelgaard, John Markenvard, Jan Børger, Jorgen Solgaard, Ebbe Eriksen, Thomas Løkkegaard, Michael Bruun, Jacob Mertz, Joël Ohayon, Yannick Gottwalles, Philippe Loiselet, Mohamed Bassel Koujan, André Marquand, Jean-Pierre Cebron, Maxime Guenoun, Dominique Guedj-Meynier, A G Lokesh, James Kadouch, Pierre-Yves Fournier, Jean-Pierre Huberman, Nestor Lemaire, Gilles Rodier, Xavier Vandamme, Marie Hélène Mahagne, Antoine Mielot, Jean-Baptiste Churet, Vincent Navarre, Frederic Sellem, Gilles Monniot, Jean-Paul Boyes, Désiré Obadia, Etienne Bearez, Jean Philippe Brugnaux, Alain Fedorowsky, Jean-Baptiste Berneau, Frédéric Chemin, Sebastien Schellong, Georg Koeniger, Uwe Gerbaulet, Bernd-Thomas Kellner, Thomas Schaefer, Jan Purr, Enno Eißfeller, Heinz-Dieter Zauzig, Peter Riegel, Christoph Axthelm, Gerd-Ulrich Heinz, Holger Menke, Andreas Pustelnik, Stefan Zutz, Wolfgang Eder, Guenter Rehling, Dirk Glatzel, Norbert Ludwig, Petra Sandow, Henning Wiswedel, Cosmas Wildenauer, Steffen Schoen, Toralf Schwarz, Adyeri Babyesiza, Maximilian Kropp, Hans-Hermann Zimny, Friedhelm Kahl, Andreas Caspar, Sabine Omankowsky, Torsten Laessig, Hermann-Josef Hartmann, Hans-Walter Bindig, Gunter Hergdt, Dietrich Reimer, Joachim Hauk, Holger Michel, Praxis Dres, Werner Erdle, Wilfried Dorsch, Janna Dshabrailov, Karl-Albrecht Rapp, Reinhold Vormann, Thomas Mueller, Uwe Horstmeier, Volker Eissing, Heinz Hey, Heinz Leuchtgens, Volker Lilienweiss, Heiner Mueller, Christian Schubert, Herrmann Lauer, Thomas Buchner, Gunter Brauer, Susanne Kamin, Sylvia Baumbach, Muwafeg Abdel-Qader, Hans-Holger Ebert, Carsten Schwencke, Laszlo Karolyi, Britta Sievers, Jens-Uwe Roehnisch, Andras Vertes, Gabor Szantai, Andras Matoltsy, Nikosz Kanakaridisz, Zoltan Boda, Erno Kis, Balazs Gaszner, Ferenc Juhasz, Gizella Juhasz, Sandor Kancz, Zoltan Laszlo, Zsolt May, Ebrahim Noori, Tamas Habon, Peter Polgar, Gabriella Szalai, Sandor Vangel, Gabriella Engelthaler, Judit Ferenczi, Mihaly Egyutt, Leone Maria Cristina, Eros Tiraferri, Rita Santoro, Teresa Maria Caimi, Maria Tessitori, Roberto Cappelli, Roberto Quintavalla, Franco Cosmi, Raffaele Fanelli, Vincenzo Oriana, Raffaele Reggio, Roberto Santi, Leonardo Pancaldi, Jorge Salerno Uriate, Flavia Lillo, Enrico Maria Pogliani, Michele Accogli, Antonio Mariani, Mauro Feola, Arturo Raisaro, Luciano Fattore, Andrea Mauric, Fabrizio Germini, Luca Tedeschi, Maria Settimi, Sergio Nicoli, Paolo Ricciarini, Antonio Argena, Paolo Ronchini, Claudio Bulla, Filippo Tradati, Maria Grazia Bongiorni, Enrico Salomone, Claudio Tondo, Saverio Iacopino, Andreas Lucassen, Henk Adriaansen, Maarten Bongaerts, Mathijs Pieterse, Johannes Herrman, Pieter Hoogslag, Cees Buiks, Per Anton Sirnes, Erik Gjertsen, Knut Erga, Arne Hallaråker, Gunnar Skjelvan, Beraki Ghezai, Arne Svilaas, Peter Christersson, Svein Høegh Henrichsen, Jan Erik Otterstad, Jan Berg-Johansen, Andrzej Gieroba, Malgorzata Biedrzycka, Michal Ogorek, Beata Wozakowska-Kaplon, Krystyna Loboz-Grudzien, Jerzy Kuzniar, Roman Zaluska, Jaroslaw Hiczkiewicz, Lucyna Swiatkowska-Byczynska, Lech Kucharski, Piotr Minc, Maciej Olszewski, Grzegorz Kania, Malgorzata Krzciuk, Zbigniew Lajkowski, Bozenna Ostrowska-Pomian, Jerzy Lewczuk, Elzbieta Zinka, Agnieszka Karczmarczyk, Malgorzata Chmielnicka-Pruszczynska, Iwona Wozniak-Skowerska, Marek Bronisz, Marcin Ogorek, Grazyna Glanowska, Piotr Ruszkowski, Grzegorz Skonieczny, Ryszard Sciborski, Boguslaw Okopien, Piotr Kukla, Krzysztof Galbas, Krzysztof Cymerman, Jaroslaw Jurowiecki, Pawel Miekus, Stanislaw Mazur, Roman Lysek, Jacek Baszak, Teresa Rusicka-Piekarz, Ewa Domanska, Jozef Lesnik, Gadel Kamalov, Dmitry Belenky, Liudmila Egorova, Alexander Khokhlov, Eduard Yakupov, Dmitry Zateyshchikov, Olga Miller, Evgeniy Mazur, Konstantin Zrazhevskiy, Tatyana Novikova, Yulia Moiseeva, Elena Polkanova, Konstantin Sobolev, Maria Rossovskaya, Yulia Shapovalova, Alla Kolesnikova, Konstantin Nikolaev, Oksana Zemlianskaia, Anna Zateyshchikova, Victor Kostenko, Maria Poltavskaya, Anton Edin, Elena Aleksandrova, Oksana Drapkina, Alexander Vishnevsky, Oleg Nagibovich, Petr Chizhov, Svetlana Rachkova, Mikhail Sergeev, Borys Kurylo, Alexey Ushakov, Pere Alvarez Garcia, Luis Tercedor Sanchez, Salvador Tranche Iparraguirre, Pere Toran Monserrat, Emilio Marquez Contreras, Jordi Isart Rafecas, Juan Motero Carrasco, Casimiro Gomez Pajuelo, Angel Grande Ruiz, Jordi Merce Klein, Ines Monte Collado, Herminia Palacin Piquero, Carles Brotons Cuixart, Esther Fernandez Escobar, Cecilia Corros Vicente, Manuel Vida Gutierrez, Francisco Epelde Gonzalo, Encarnacion Martinez Navarro, Maria Barreda Gonzalez, Jose Iglesias Sanmartin, Mercedes Jimenez Gonzalez, Juan Herreros Melenchon, Tomas Ripoll Vera, Manuel Jimenez Navarro, Maria Vazquez Caamano, Gonzalo Marcos Gomez, Andres Iniguez Romo, Alexander Wirdby, Kerstin Henriksson, Micael Elmersson, Arnor Egilsson, Ulf Börjesson, Gunnar Svärd, Anders Lindh, Lars-Bertil Olsson, Mikael Gustavsson, Lars Benson, Claes Bothin, Ali Hajimirsadeghi, Björn Martinsson, Marianne Ericsson, Åke Ohlsson, Håkan Lindvall, Peter Svensson, Katarina Thörne, Hans Händel, Pyotr Platonov, Fredrik Bernsten, Ingar Timberg, Milita Crisby, Lennart Malmqvist, Jörgen Thulin, Aida Hot-Bjelak, Steen Jensen, Per Stalby, Johann Debrunner, Iurii Rudyk, Oleksandr Karpenko, Svitlana Zhurba, Igor Kraiz, Oleksandr Parkhomenko, Iryna Kupnovytska, Nestor Seredyuk, Oleksiy Ushakov, Olena Koval, Igor Kovalskiy, Yevgeniya Svyshchenko, Susanna Tykhonova, Ivan Fushtey, Naresh Chauhan, Daryl Goodwin, Ramila Patel, Bennett Wong, Alex Cameron, Niranjan Patel, M S Kainth, Gill Pickavance, Joanna McDonnell, Laura Handscombe, Trevor Gooding, Helga Wagner, Catherine Bromham, Shoeb Suryani, Bhupinder Sarai, W Willcock, S Sircar, A Gilliand, Roman Bilas, E Strieder, Anne Wakeman, Graham Kirby, Bhaskhar Vishwanathan, Nigel Bird, John Bisatt, Jennifer Litchfield, Tim Fooks, Richard Kelsall, Neil Paul, Elizabeth Alborough, Michael Aziz, Pete Wilson, Sue Fairhead, Hasan Chowan, Gary Taylor, Dawn Tragen, Matt Parfitt, Claire Seamark, Carolyn Paul, Angus Jefferies, Helen Sharp, Claire Giles, Matthew Bramley, Philip Williams, Jehad Aldegather, William Lumb, Phil Evans, Frances Scouller, Yvette Stipp, Philip Pinney, Paul Wadeson, T Railton, Emyr Davies, Jonathan McClure, Marc Jacobs, Claire Hutton, Keith Butter, Susan Barrow, Helen Little, Ulka Choudhary, Ikram Haq, Paul Ainsworth, Phil Weeks, Jane Eden, Lisa Gibbons, Janet Glencross, K Poland, Conor Mulolland, A Warke, Ian Hodgins, Stephen Vercoe, Jayesh Patel, Amar Ali, Nigel De-Sousa, Mark Danielsen, Purnima Sharma, Sophia Galloway, Charlotte Hawkins, Raife Oliver, Martin Aylward, Mira Pattni, Shahid Ahmad, Catherine Rothwell, Fiaz Choudhary, Sabrina Khalaque, Stephanie Short, Sharon Peters, Amy Butler, Steven Coates, Steve Walton, Diane Shepherd, Toh Wong, Melanie Deacon, David Cornelius, Henry Choi, Jon Sumner, Tim Myhill, Salah Estifanos, Diane Geatch, Justin Wilkinson, Richard Veale, Rob Hirst, Kashif Zaman, Catherine Liley, Rebecca Wastling, Paul McEleny, Andre Beattie, Mike Wong, Chaminda Dooldeniya, Greg Rogers, Rajesh Muvva, Matthew Adam, Nicolas Thomas, Rory Reed, Simon Randfield, Ann Flynn, Andrew Halpin, Louise Lomax, Minnal Nadaph, Iain Munro, Jane Goram, John Shewring, Emma Bowen-Simpkins, Bhuwanendu Singh, Penny Astridge, Philip Thomson, Ron Lehman, Andrei Catanchin, David Eccleston, Peter Blombery, Greg Starmer, Margaret Arstall, Maurits Binnekamp, Astin Lee, Robert Luton, Amritanshu Shekhar Pandey, Stephen Cheung, Rolland Leader, Philippe Beaudry, Félix Ayala-Paredes, John Heath, Germain Poirier, Bradley Schweitzer, Reginald Nadeau, Ripple Dhillon, Tomasz Hruczkowski, Andrea Lavoie, Ratika Parkash, James Cha, Benoit Coutu, Jorge Bonet, Saul Vizel, Sameh Fikry, Ahmed Mowafy, Azza Katta, Mazen Tawfik, Moustafa Nawar, Mohamed Sobhy, Tarek Khairy, Ahmed Abd El-Aziz, Ashraf Reda, Atef Elbahry, Mohamed Setiha, Magdi Elkhadem, Adel El-Etreby, David Kettles, Junaid Bayat, Heidi Siebert, Adrian Horak, Ynez Kelfkens, Riaz Garda, Thayabran Pillay, Michele Guerra, Hendrik Theron, Rikus Louw, Deon Greyling, Pindile Mntla, Siddique Ismail, Fayzal Ahmed, Johannes Engelbrecht, Shambu Maharajh, Veronica Ueckermann, Ghazi Yousef, Munther AlOmairi, Rajan Maruthanayagam, Rupesh Singh, Ahmed Naguib, Amrish Agrawal, Mukesh Nathani, Adel Wassef, Scott Beach, Peter Duffy, Stephen Falkowski, Kevin Ferrick, Miguel Franco, Annette Quick, Vance Wilson, Mark Alberts, Edwin Blumberg, Roddy Canosa, Ted Gutowski, Rodney Ison, Jorge Garcia, Howard Noveck, Pamela Rama, Rajneesh Reddy, Marcus Williams, Keith Ferdinand, Ihsan Haque, Robert Mendelson, Sridevi Pitta, Charles Treasure, Cas Cader, Walter Pharr, Alisha Oropallo, George Platt, Jaspal Gujral, James Welker, Firas Koura, Ajay K. Kakkar, A. John Camm, David A. Fitzmaurice, Keith A.A. Fox, Bernard J. Gersh, Samuel Z. Goldhaber, Lorenzo G. Mantovani, Karen S. Pieper, Alexander G.G. Turpie, Freek W.A. Verheugt, Antonio Carlos PereiraBarretto, Stuart J. Connolly, Jean-Yves Le Heuzey, Jitendra Pal SinghSawhney, Carlos JerjesSánchez Díaz, Hugo Ten Cate, Wael Al Mahmeed, Zhiming Yang Li Xue, A.G. Ravi Shankar, Chiei Takanaka Sen Adachi, Rodolfo AndresAhuad Guerrero, Leonel Adalberto Di Paola, DárioCelestino Sobral Filho, Costantino RobertoFrack Costantini, Weimar Kunz SebbaBarrosodeSouzaem, João David deSouzaNeto, José Carlos MouraJorge, Adalberto MenezesLorga Filho, Carlos Henrique DelCarlo, FernandoAugustoAlves da Costa, Gilson Robertode Araújo, Jose FranciscoKerr Saraiva, João CarlosFerreira Braga, Roberto Álvaro RamosFilho, Cláudio MunhozdaFontoura Tavares, CésarCássio Broilo França, Guido BernardoAranha Rosito, João BatistadeMouraXavierMoraes Junior, Roberto Simõesde Almeida, Ney CarterdoCarmo Borges, LuísGustavo Gomes Ferreira, Benjamin AleckJosehStockins Fernandez, CarlosJerjes Sanchez Diaz, Jesus JaimeIllescas Diaz, Maria GuadalupeRamos Zavala, GuillermoAntonio Llamas Esperón, Manuel delosRios Ibarra, LuisRamon Virgen Carrillo, JuanJose Lopez Prieto, Jose LuisLeiva Pons, Carlos GerardoCantu Brito, EduardoJulianJose Roberto ChuquiureValenzuela, Alberto EstebanBazzoni Ruiz, Oscar MartinLopez Ruiz, Jesus DavidMorales Cerda, Axel De Wolf, Carmela Viitanen, Giovanni Di Minno, Raimondo De Cristofaro, Angelo De Blasio, Maria D'Avino, J.H. Ruiter, Coen van Guldener, P.R. Nierop S.H.K., B.E. Groenemeijer, W. Terpstra, L.V.A. Boersma, Wieslaw Supinski Jaroslaw, Roman Libis Vera Eltishcheva, Maria FernandaLopez Fernandez, Luis MiguelRincon Diaz, Luis FernandoIglesias Alonso, Jose RamonGonzalez Juanatey, Joan Bayo iLlibre, Carlos AlexandreAlmeida Fernandez, Juan JoseMontero Alia, Maria AngelsMoleiro Oliva, Maria delMarRodriguez Alvarez, Maria FeArcocha Torres, Miguel AngelPrieto Diaz, Jan Lindén Centrumkliniken, Juerg H. Beer, Colin Bradshaw Cumberlidge, Daniel Jackson Ben Ward, Nick Hargreaves Ben Frankel, William van Gaal, David O'Donnell, Miranda du Preez, Seif Kamal Abou Seif, Mohamed Gamal El Din, Louis van Zyl, Rehana Loghdey Wessel Oosthuysen, Abdullah Al Naeemi, Ehab M. Esheiba, and W. Michael Kutayli
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objective While greater body mass index (BMI) is associated with increased risk of developing atrial fibrillation (AF), the impact of BMI on outcomes in newly diagnosed AF is unclear. We examine the influence of BMI on outcomes and whether this is modified by sex and evaluate the effect of non-vitamin K oral anticoagulants (NOACs) in patients with high BMI.Methods GARFIELD-AF is a prospective registry of 52 057 newly diagnosed AF patients. The study population comprised 40 482 participants: 703 underweight (BMI
- Published
- 2022
- Full Text
- View/download PDF
7. Changes in LA volume and diameter correlate with mechanisms of recurrence after paroxysmal AF ablation
- Author
-
Eric Buffle, Nicolas Johner, Mehdi Namdar, and Dipen Shah
- Subjects
Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Papathanasiou et al point out that the two different methods of LA volume and diameter measurement in our recent publication could limit the significance of the correlations we reported with PV reconnection and non-PV foci as mechanisms of post AF ablation recurrence. While we acknowledge the lack of statistically significant correlations of smaller echo derived LA diameter with PV reconnection or of a larger angiographic LA volume with non-PV foci, the congruent confidence intervals of this correlation suggest a statistical trend. Non-uniform LA dimensional changes as an expression of structural remodelling may also be a possible explanation. Published data indicates that angiographic LA volumes consistently exhibit a positive bias compared to echocardiographic volumes but do provide intra-procedural measurements better correlating with gold standard techniques like CT or MRI. Finally we agree with Papathanasiou et al that dynamic changes in LA dimensions likely correlate with early and late mechanisms of recurrence and merit prospective studies.
- Published
- 2022
- Full Text
- View/download PDF
8. Incidence and Predictors of Atrial Fibrillation Progression
- Author
-
Steffen Blum, Stefanie Aeschbacher, Pascal Meyre, Leon Zwimpfer, Tobias Reichlin, Jürg H. Beer, Peter Ammann, Angelo Auricchio, Richard Kobza, Paul Erne, Giorgio Moschovitis, Marcello Di Valentino, Dipen Shah, Jürg Schläpfer, Selina Henz, Christine Meyer‐Zürn, Laurent Roten, Matthias Schwenkglenks, Christian Sticherling, Michael Kühne, Stefan Osswald, and David Conen
- Subjects
atrial fibrillation ,epidemiology ,predictors ,progression ,rhythm control ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background The incidence and predictors of atrial fibrillation (AF) progression are currently not well defined, and clinical AF progression partly overlaps with rhythm control interventions (RCIs). Methods and Results We assessed AF type and intercurrent RCIs during yearly follow‐ups in 2869 prospectively followed patients with paroxysmal or persistent AF. Clinical AF progression was defined as progression from paroxysmal to nonparoxysmal or from persistent to permanent AF. An RCI was defined as pulmonary vein isolation, electrical cardioversion, or new treatment with amiodarone. During a median follow‐up of 3 years, the incidence of clinical AF progression was 5.2 per 100 patient‐years, and 10.9 per 100 patient‐years for any RCI. Significant predictors for AF progression were body mass index (hazard ratio [HR], 1.03; 95% CI, 1.01–1.05), heart rate (HR per 5 beats/min increase, 1.05; 95% CI, 1.02–1.08), age (HR per 5‐year increase 1.19; 95% CI, 1.13–1.27), systolic blood pressure (HR per 5 mm Hg increase, 1.03; 95% CI, 1.00–1.05), history of hyperthyroidism (HR, 1.71; 95% CI, 1.16–2.52), stroke (HR, 1.50; 95% CI, 1.19–1.88), and heart failure (HR, 1.69; 95% CI, 1.34–2.13). Regular physical activity (HR, 0.80; 95% CI, 0.66–0.98) and previous pulmonary vein isolation (HR, 0.69; 95% CI, 0.53–0.90) showed an inverse association. Significant predictive factors for RCIs were physical activity (HR, 1.42; 95% CI, 1.20–1.68), AF‐related symptoms (HR, 1.84; 95% CI, 1.47–2.30), age (HR per 5‐year increase, 0.88; 95% CI, 0.85–0.92), and paroxysmal AF (HR, 0.61; 95% CI, 0.51–0.73). Conclusions Cardiovascular risk factors and comorbidities were key predictors of clinical AF progression. A healthy lifestyle may therefore reduce the risk of AF progression.
- Published
- 2019
- Full Text
- View/download PDF
9. Biomarkers and arrhythmia recurrence following radiofrequency ablation of atrial fibrillation
- Author
-
David Carballo, Stephane Noble, Sebastian Carballo, Jérome Stirnemann, Hajo Muller, Haran Burri, Nicolas Vuilleumier, Mario Talajic, Jean-Claude Tardif, Pierre-Frederic Keller, Francois Mach, and Dipen Shah
- Subjects
Medicine (General) ,R5-920 - Abstract
Objective Atrial fibrillation (AF) is the most common cardiac arrhythmia, and radiofrequency catheter ablation of AF (RCAAF) has become increasingly popular. Cardiac stress and inflammation have been associated with AF. This study was performed to determine whether the pre- or post-AF ablation levels of high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro–B-type natriuretic peptide (NT-proBNP) are predictive of AF recurrence. Methods This multicenter prospective cohort study involved patients undergoing RCAAF in Switzerland and Canada. The primary endpoint was the recurrence of AF or atrial flutter at 6 months. Results Of 202 patients, 195 completed follow-up (age, 57.5 ± 9 years; mean left ventricular ejection fraction, 62%; mean left atrial size, 19.4 cm 2 ). Patients with AF recurrence had larger atrial surfaces and longer total RCAAF times. Both the pre-ablation hs-CRP level and 1-day post-RCAAF NT-proBNP level were significantly associated with an increased risk of recurrence. Conclusions The pre-ablation hs-CRP level and immediate post-ablation NT-proBNP level were markers for atrial arrhythmia recurrence after RCAAF. This confirms growing evidence of the role of inflammation in the pathogenesis of AF. These biomarkers appear to be promising stratification tools for selection and management of patients undergoing RCAAF.
- Published
- 2018
- Full Text
- View/download PDF
10. Prevalence and predictors of atrial fibrillation type among individuals with recent onset of atrial fibrillation
- Author
-
Francisco J. Ruperti Repilado, Laura Doerig, Steffen Blum, Stefanie Aeschbacher, Philipp Krisai, Peter Ammann, Paul Erne, Giorgio Moschovitis, Marcello di Valentino, Dipen Shah, Jürg Schläpfer, Samuel Stempfel, Michael Kühne, Christian Sticherling, Stefan Osswald, and David Conen
- Subjects
atrial fibrillation ,Epidemiology ,recent onset ,Medicine - Abstract
OBJECTIVE Atrial fibrillation (AF) is considered to be a progressive disease, starting with intermittent episodes that progress over time to more sustained events. However, little is known about the prevalence of and predictors for AF type among patients with recent-onset AF. We aimed to address these issues among a selected population of patients with AF. METHODS The Basel atrial fibrillation cohort (BEAT-AF) study is an ongoing prospective multicentre cohort study among patients with AF. At baseline, we obtained information on the date of AF diagnosis, AF type, comorbidities, medication and lifestyle factors. For this analysis, 486 (31.4%) out of 1550 participants with recent-onset AF (defined as AF duration
- Published
- 2018
- Full Text
- View/download PDF
11. Risk factors for heart failure hospitalizations among patients with atrial fibrillation.
- Author
-
Lucien Eggimann, Steffen Blum, Stefanie Aeschbacher, Andreas Reusser, Peter Ammann, Paul Erne, Giorgio Moschovitis, Marcello Di Valentino, Dipen Shah, Jürg Schläpfer, Nadine Mondet, Michael Kühne, Christian Sticherling, Stefan Osswald, and David Conen
- Subjects
Medicine ,Science - Abstract
Patients with atrial fibrillation (AF) have an increased risk for the development of heart failure (HF). In this study, we aimed to detect predictors of HF hospitalizations in an unselected AF population.The Basel Atrial Fibrillation Cohort Study is an ongoing observational multicenter cohort study in Switzerland. For this analysis, 1193 patients with documented AF underwent clinical examination, venous blood sampling and resting 12-lead ECG at baseline. Questionnaires about lifestyle and medical history were obtained in person at baseline and during yearly follow-up phone calls. HF hospitalizations were validated by two independent physicians. Cox regression analyses were performed using a forward selection strategy.Overall, 29.8% of all patients were female and mean age was 69 ±12 years. Mean follow-up time was 3.7 ±1.5 years. Hospitalization for HF occurred in 110 patients, corresponding to an incidence of 2.5 events per 100 person years of follow-up. Independent predictors for HF were body mass index (HR 1.40 [95%CI 1.17; 1.66], p = 0.0002), chronic kidney disease (2.27 [1.49; 3.45], p = 0.0001), diabetes mellitus (2.13 [1.41; 3.24], p = 0.0004), QTc interval (1.25 [1.04; 1.49], p = 0.02), brain natriuretic peptide (2.19 [1.73; 2.77], p
- Published
- 2018
- Full Text
- View/download PDF
12. Design of the Swiss Atrial Fibrillation Cohort Study (Swiss-AF): structural brain damage and cognitive decline among patients with atrial fibrillation
- Author
-
David Conen, Nicolas Rodondi, Andreas Müller, Juerg H. Beer, Angelo Auricchio, Peter Ammann, Daniel Hayoz, Richard Kobza, Giorgio Moschovitis, Dipen Shah, Jürg Schläpfer, Jan Novak, Marcello Di Valentino, Paul Erne, Christian Sticherling, Leo H. Bonati, Georg Ehret, Laurent Roten, Urs Fischer, Andreas Monsch, Christoph Stippich, Jens Wuerfel, Matthias Schwenkglenks, Michael Kühne, Stefan Osswald, and for the Swiss-AF study investigators
- Subjects
atrial ,atrial fibrillation ,cognitive decline ,decline ,dementia ,Imaging ,Medicine - Abstract
BACKGROUND Several studies found that patients with atrial fibrillation (AF) have an increased risk of cognitive decline and dementia over time. However, the magnitude of the problem, associated risk factors and underlying mechanisms remain unclear. METHODS This article describes the design and methodology of the Swiss Atrial Fibrillation (Swiss-AF) Cohort Study, a prospective multicentre national cohort study of 2400 patients across 13 sites in Switzerland. Eligible patients must have documented AF. Main exclusion criteria are the inability to provide informed consent and the presence of exclusively short episodes of reversible forms of AF. All patients undergo extensive phenotyping and genotyping, including repeated assessment of cognitive functions, quality of life, disability, electrocardiography and cerebral magnetic resonance imaging. We also collect information on health related costs, and we assemble a large biobank. Key clinical outcomes in Swiss-AF are death, stroke, systemic embolism, bleeding, hospitalisation for heart failure and myocardial infarction. Information on outcomes and updates on other characteristics are being collected during yearly follow-up visits. RESULTS Up to 7 April 2017, we have enrolled 2133 patients into Swiss-AF. With the current recruitment rate of 15 to 20 patients per week, we expect that the target sample size of 2400 patients will be reached by summer 2017. CONCLUSION Swiss-AF is a large national prospective cohort of patients with AF in Switzerland. This study will provide important new information on structural and functional brain damage in patients with AF and on other AF related complications, using a large variety of genetic, phenotypic and health economic parameters.
- Published
- 2017
- Full Text
- View/download PDF
13. Prospective Assessment of Sex‐Related Differences in Symptom Status and Health Perception Among Patients With Atrial Fibrillation
- Author
-
Steffen Blum, Christoph Muff, Stefanie Aeschbacher, Peter Ammann, Paul Erne, Giorgio Moschovitis, Marcello Di Valentino, Dipen Shah, Jürg Schläpfer, Andreas Fischer, Tamara Merkel, Michael Kühne, Christian Sticherling, Stefan Osswald, and David Conen
- Subjects
atrial fibrillation ,epidemiology ,health perception ,sex‐related differences ,symptoms ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundWe prospectively assessed sex‐specific differences in health perception, overall symptom status, and specific symptoms in a large cohort of patients with atrial fibrillation. Methods and ResultsWe performed a prospective multicenter observational cohort study of 1553 patients with atrial fibrillation. Patients completed questionnaires about personal characteristics, comorbidities, and symptoms on a yearly basis. Mean age was 70±11 years among women and 67±12 years among men. Health perception on a visual analogue scale ranging from 0 to 100 (with higher scores indicating better health perception) was significantly lower in women than in men (70 [interquartile range: 50–80] versus 75 [interquartile range: 60–85]; P
- Published
- 2017
- Full Text
- View/download PDF
14. Uptake of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation – a prospective cohort study
- Author
-
Matylda Zimny, Steffen Blum, Peter Ammann, Paul Erne, Giorgio Moschovitis, Marcello Di Valentino, Dipen Shah, Jürg Schläpfer, Cyrill Vogt, Alexandra Tabord, Michael Kühne, Christian Sticherling, Stefan Osswald, and David Conen
- Subjects
atrial fibrillation ,Epidemiology ,NOAC ,oral anticoagulation ,stroke ,Medicine - Abstract
AIMS We aimed to assess the uptake of non-vitamin K antagonist oral anticoagulants (NOACs) among patients with atrial fibrillation between 2010 and 2015 in Switzerland. METHODS We performed a prospective observational cohort study. At the baseline examination and during yearly follow-ups, we used questionnaires to obtain information about clinical characteristics and antithrombotic treatment. Stroke risk was assessed using the CHA2DS2-VASc score. RESULTS 1545 patients were enrolled across seven centres in Switzerland. Mean age was 68 ± 12 years and 29.5% were female. The percentage of anticoagulated patients with an indication for oral anticoagulation (CHA2DS2-VASc score ≥2 in women and ≥1 in men) was 75% in 2010 and 80% in 2015 (p = 0.2). There was a gradual increase in the use of NOACs from 0% in 2010 to 29.8% in 2015 (p
- Published
- 2017
- Full Text
- View/download PDF
15. Black triangle dilemma and its management in esthetic dentistry
- Author
-
Vijendra P Singh, Ashita S Uppoor, Dilip G Nayak, and Dipen Shah
- Subjects
Black triangle disease ,interdental papilla ,pink esthetics ,white esthetics ,Dentistry ,RK1-715 - Abstract
In recent years, clinician and dentist′s esthetic demand in dentistry have increased rapidly, driven by an enhanced awareness of beauty and esthetics. The ultimate goal in modern restorative dentistry is to achieve "white" and "pink" esthetics in esthetically important zones. "White esthetics" is the natural dentition or the restoration of dental hard tissues with suitable materials. "Pink esthetics" refers to the surrounding soft-tissues, which includes the interdental papilla and gingiva that can enhance or diminish the esthetic result. Reconstruction of the lost interdental papilla is one of the most challenging and least predictable problems. Restoration and maintenance of these tissues with adequate surgical and prosthetic techniques are a real challenge in modern esthetic dentistry. Treatment of marginal tissue recession, excessive gingival display, deficient ridges, ridge collapse, and esthetic defects around teeth and implants are some of the esthetic problems associated with the interdental papilla that have to be corrected in todays scenario which has been discussed in this review.
- Published
- 2013
- Full Text
- View/download PDF
16. Clinical and radiographic evaluation of Nano-crystalline hydroxyapatite bone graft (Sybograf®) in combination with bioresorbable collagen membrane (Periocol®) in periodontal intrabony defects
- Author
-
Vijendra P Singh, Dilip G Nayak, Ashita S Uppoor, and Dipen Shah
- Subjects
Bone graft ,collagen membrane ,nanocrystalline hydroxyapatite ,periodontal regeneration ,Dentistry ,RK1-715 - Abstract
Background: Nanosized ceramics may represent a promising class of bone graft substitutes due to their improved osseointegrative properties. Nanocrystalline Hydroxyapatite (NcHA) bind to bone and stimulate bone healing by stimulation of osteoblast activity. The present study aims to explore the clinical and radiographical outcome of NcHA bonegraft (Sybograf® ) with collagen membrane (Periocol® ), in comparison with open flap debridement (OFD), in the treatment of intrabony periodontal defects. Materials and Methods: A parallel-group, randomized, controlled clinical trial was designed to conduct the study. Eighteen intrabony defects in 14 systemically healthy patients aged between 25 to 65 years were randomly assigned to test and control group. The plaque index, gingival index, probing pocket depth (PPD), clinical attachment level (CAL), and gingival recession (REC) were recorded at baseline, and were reevaluated at 6 months. In addition to this, radiographic bone fill was assessed using digital software. At the test site, NcHA bone graft and collagen membrane was placed, whereas at the control site, only OFD was done. Recall appointments were made at 7 days, 30 days, and then at 3 months and 6 months. Results: The data were subjected to statistical analysis using the Mann-Whitney ′U′ Test and Wilcoxon signed rank sum test. In the control group, the mean reduction of PPD was 3.22±1.09 mm (P=0.007) and CAL gain was 2.77±1.09 mm (P=0.007). In the test group, the mean PPD reduction of 4.33±0.5 mm (P=0.006) and mean gain in CAL was 3.77±0.66 mm (P=0.006) at 6 months. The mean increase in REC was 0.55±0.72 mm (P=0.025) in test, and 0.44±0.52 mm (P=0.046) in control group. The mean gain in radiographic defect fill was 2.07±0.67 mm (P=0.008) in test and 0.91±0.21 mm (P=0.007) in control group. Conclusion: The nanocrystalline hydroxyapatite bone graft in combination with collagen membrane demonstrated clinical advantages beyond that achieved by OFD alone.
- Published
- 2012
- Full Text
- View/download PDF
17. Evaluating Pulmonary Vein Isolation
- Author
-
Dipen Shah, MD
- Subjects
PV electrophysiology ,Circular mapping ,Entrance block ,Exit block ,Farfield electrograms ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Pulmonary vein isolation is the electrophysiological endpoint of complete conduction block at the level of the veno-atrial junction and must be explicitly distinguished from encircling PV ablation which frequently does not result in isolation. The prerequisites for successful PV isolation include a knowledge of the individual anatomy of the PVs and the left atrium, appropriate positioning of circular mapping catheters, and a knowledge of the electrophysiology of PV activation, in addition to effective ablation tools. Excessive ablation, and possibly complications, can be avoided by the recognition of non-PV myocardial contributions to electrograms recorded from within the PVs. The posterior wall of the left atrial appendage contributes far-field electrograms to recordings from all or nearly all left superior PVs, the low anterior left atrium to 80% of left inferior PV recordings and the superior vena cava to 23% of right superior PV recordings. Recognition of these far-field components is feasible and accurate in sinus rhythm as well as during ongoing atrial fibrillation. Finally, the creation of temporally stable PV isolation remains a currently unsolved problem although prolonged post isolation surveillance, may be helpful.
- Published
- 2008
- Full Text
- View/download PDF
18. Correction: Electrocardiographic Screening for Prolonged QT Interval to Reduce Sudden Cardiac Death in Psychiatric Patients: A Cost-Effectiveness Analysis.
- Author
-
Antoine Poncet, Baris Gencer, Marc Blondon, Marianne Gex-Fabry, Christophe Combescure, Dipen Shah, Peter J Schwartz, Marie Besson, and François R Girardin
- Subjects
Medicine ,Science - Published
- 2015
- Full Text
- View/download PDF
19. Electrocardiographic Screening for Prolonged QT Interval to Reduce Sudden Cardiac Death in Psychiatric Patients: A Cost-Effectiveness Analysis.
- Author
-
Antoine Poncet, Baris Gencer, Marc Blondon, Marianne Gex-Fabry, Christophe Combescure, Dipen Shah, Peter J Schwartz, Marie Besson, and François R Girardin
- Subjects
Medicine ,Science - Abstract
IMPORTANCE:Sudden cardiac death is a leading cause of mortality in psychiatric patients. Long QT (LQT) is common in this population and predisposes to Torsades-de-Pointes (TdP) and subsequent mortality. OBJECTIVE:To estimate the cost-effectiveness of electrocardiographic screening to detect LQT in psychiatric inpatients. DESIGN, SETTING, AND PARTICIPANTS:We built a decision analytic model based on a decision tree to evaluate the cost-effectiveness and utility of LQT screening from a health care perspective. LQT proportion parameters were derived from an in-hospital cross-sectional study. We performed experts' elicitation to estimate the risk of TdP, given extent of QT prolongation. A TdP reduction of 65% after LQT detection was based on positive drug dechallenge rate and through adequate treatment and electrolyte adjustments. The base-case model uncertainty was assessed with one-way and probabilistic sensitivity analyses. Finally, the TdP related mortality and TdP avoidance parameters were varied in a two-way sensitivity analysis to assess their effect on the Incremental Cost-Effectiveness Ratio (ICER). MAIN OUTCOMES AND MEASURES:Costs, Quality Ajusted Life Year (QALY), ICER, and probability of cost effectiveness thresholds ($ 10,000, $25,000, and $50,000 per QALY). RESULTS:In the base-case scenario, the numbers of patients needed to screen were 1128 and 2817 to avoid one TdP and one death, respectively. The ICER of systematic ECG screening was $8644 (95%CI, 3144-82 498) per QALY. The probability of cost-effectiveness was 96% at a willingness-to-pay of $50,000 for one QALY. In sensitivity analyses, results were sensitive to the case-fatality of TdP episodes and to the TdP reduction following the diagnosis of LQT. CONCLUSION AND RELEVANCE:In psychiatric hospitals, performing systematic ECG screening at admission help reduce the number of sudden cardiac deaths in a cost-effective fashion.
- Published
- 2015
- Full Text
- View/download PDF
20. Extreme bradycardia and transient asystole after massive gastric air entrapment
- Author
-
Cheryl Teres, MD, Mehdi Namdar, MD, PhD, and Dipen Shah, MD, FHRS
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2016
- Full Text
- View/download PDF
21. Recent advances in metal oxide/polylactic acid nanocomposites and their applications
- Author
-
Anuradha Rathore, Dipen Shah, and Harjinder Kaur
- Subjects
Polymers and Plastics ,General Chemical Engineering ,Materials Chemistry - Published
- 2022
- Full Text
- View/download PDF
22. GARFIELD-AF: risk profiles, treatment patterns and 2-year outcomes in patients with atrial fibrillation in Germany, Austria and Switzerland (DACH) compared to 32 countries in other regions worldwide
- Author
-
Sylvia, H, John A, C, Darius, H, Jan, S, Saverio, V, Karen, P, Marianne, B, Sebastian, S, Frank, M, Gloria, K, Kakkar, A, Bassand, J, John Camm, A, Fitzmaurice, D, Fox, K, Gersh, B, Goldhaber, S, Goto, S, Haas, S, Hacke, W, Mantovani, L, Misselwitz, F, Pieper, K, Turpie, A, van Eickels, M, Verheugt, F, Gersh, K, Lucas Luciardi Harry Gibbs, H, Brodmann, M, Cools, F, Carlos Pereira Barretto, A, Connolly, S, Eikelboom, J, Corbalan, R, Jing, Z, Jansky, P, Dalsgaard Nielsen, J, Ragy, H, Raatikainen, P, Le Heuzey, J, Keltai, M, Pal Singh Sawhney, J, Agnelli, G, Ambrosio, G, Koretsune, Y, Jerjes Sánchez Díaz, C, Ten Cate, H, Atar, D, Stepinska, J, Panchenko, E, Wei Lim, T, Jacobson, B, Oh, S, Viñolas, X, Rosenqvist, M, Steffel, J, Angchaisuksiri, P, Oto, A, Parkhomenko, A, Al Mahmeed, W, Hu Kangning Chen, D, Zhao, Y, Zhang, H, Chen, J, Cao, S, Wang, D, Yang, Y, Li, W, Li, H, Yin, Y, Tao, G, Yang, P, Chen, Y, He, S, Wang, Y, Fu, G, Li, X, Wu, T, Cheng, X, Yan, X, Zhao, R, Chen, M, Xiong, L, Chen, P, Jiao, Y, Guo, Y, Xue, L, Yang, Z, Jadhavm Raghava Sarma, P, Kulkarni, G, Chandwani, P, Atulbhai Pothiwala, R, Padinhare Purayil, M, Chawla, K, Annasaheb Kothiwale, V, Raghuraman, B, Madan Vijan, V, Sawhney, J, Bantwal, G, Khan, A, Meena, R, Chopada, M, Abraham, S, Bisne, V, Vijayaraghavan, G, Roy, D, Durgaprasad, R, Ravi Shankar, A, Kumar, S, Jain, D, Bhargava, K, Kumar, V, Madappa Nagamalesh, U, Kumar Rajput, R, Koretsune Seishu Kanamori, Y, Yamamoto, K, Kumagai, K, Katsuda, Y, Yoshida, K, Toyota, F, Mizuno, Y, Misumi, I, Noguchi, H, Ando, S, Suetsugu, T, Minamoto, M, Oda, H, Adachi, S, Chiba, K, Norita, H, Tsuruta, M, Koyanagi, T, Ando, H, Higashi, T, Okada, M, Azakami, S, Komaki, S, Kumeda, K, Murayama, T, Matsumura, J, Oba, Y, Sonoda, R, Goto, K, Minoda, K, Haraguchi, Y, Suefuji, H, Miyagi, H, Kato, H, Nakamura, T, Nandate, H, Zaitsu, R, Fujiura, Y, Yoshimura, A, Numata, H, Ogawa, J, Kamogawa, Y, Murakami, K, Wakasa, Y, Yamasawa, M, Maekawa, H, Abe, S, Kihara, H, Tsunoda, S, Saito, K, Tachibana, H, Oba, I, Kuwahata, T, Higa, S, Gushiken, M, Eto, T, Chibana, H, Fujisawa, K, Shiga, Y, Sumi, H, Nagatomo, T, Atsuchi, Y, Nagoshi, T, Sanno, K, Hoshino, F, Yokota, N, Kameko, M, Tabuchi, T, Ishizawa, M, Ikeda, D, Seto, T, Iwao, T, Ishioka, N, Oshiro, K, Tsuchida, K, Hatori, Y, Takeuchi, M, Takezawa, H, Nagano, S, Iwaki, M, Nakamura, Y, Miyamoto, N, Taguchi, T, Ashida, K, Yoshizawa, N, Agata, J, Matsukawa, S, Arasaki, O, Fukuoka, S, Murakami, H, Mishima, K, Hata, Y, Sakuma, I, Obunai, K, Takamura, I, Akutsu, M, Unoki, T, Go, Y, Ikemura, M, Morii, S, Marusaki, S, Doi, H, Tanaka, M, Kusumoto, T, Kakinoki, S, Ogurusu, C, Murata, K, Shimoyama, M, Nakatsuka, M, Kitami, Y, Oyama, R, Ageta, M, Mita, T, Nagao, K, Mito, T, Minami, J, Abe, M, Fujii, M, Okawa, M, Fujito, T, Taniguchi, T, Ko, T, Kubo, H, Imamaki, M, Akiyama, M, Ueda, T, Odakura, H, Inagaki, M, Katsube, Y, Nakata, A, Tomimoto, S, Shibuya, M, Nakano, M, Ito, K, Matsuta, M, Ishiguro, M, Minagawa, T, Wada, M, Mukawa, H, Mizuguchi, M, Okuda, F, Kimura, T, Taga, K, Techigawara, M, Igarashi, M, Watanabe, H, Seo, T, Hiramitsu, S, Hosokawa, H, Hoshiai, M, Hibino, M, Miyagawa, K, Horie, H, Sugishita, N, Soma, A, Neya, K, Yoshida, T, Akahane, K, Takanaka, C, Matsui, S, Kanda, H, Kaneko, M, Nagasaka, S, Taguchi, A, Toru, S, Miyashita, A, Sasaguri, H, Nariyama, J, Hatsuno, T, Iwase, T, Sato, K, Kawai, K, Kotani, T, Tsuji, T, Sakai, H, Nishino, K, Ikeda, K, Maeda, K, Shinozuka, T, Inoue, T, Kawakami, K, Kitazumi, H, Takagi, T, Hamaoka, M, Kojima, J, Sasaki, A, Tsuchiya, Y, Betsuyaku, T, Higuchi, K, Honda, M, Hasegawa, K, Baba, T, Mineoi, K, Koeda, T, Hirasawa, K, Kumazaki, T, Nakagomi, A, Otaki, E, Shindo, T, Hirayama, H, Sugimoto, C, Yamagishi, T, Mizuguchi, I, Sezaki, K, Niwa, I, Takenaka, K, Iiji, O, Taya, K, Kitazawa, H, Ueda, S, Kakuda, H, Ono, T, Oriso, S, Kamata, J, Nanke, T, Maeda, I, Matsuura, Y, Teragawa, H, Maruyama, Y, Takei, K, Kito, T, Asano, H, Matsushita, K, Nakamura, M, Washizuka, T, Sawano, M, Arima, S, Arai, H, Shinohara, H, Takai, H, Furukawa, N, Ota, A, Aoki, K, Yamamoto, T, Kasai, T, Suzuki, S, Shibata, N, Watanabe, M, Nishihata, Y, Arino, T, Okuyama, M, Wakiyama, T, Kato, T, Sasagawa, Y, Tana, T, Hayashi, Y, Hirota, S, Abe, Y, Saito, Y, Uchiyama, H, Takeda, H, Ono, H, Tohyo, S, Hanazono, N, Miyajima, S, Shimono, H, Aoyama, T, Shozawa, Y, Niijima, Y, Murai, O, Inaba, H, Nomura, K, Nozoe, M, Suzuki, K, Furukawa, T, Shiraiwa, T, Ito, N, Nagai, S, Nakahara, S, Shimoyama, Y, Ohara, N, Kozuka, T, Okita, H, Endo, M, Goto, T, Hirose, M, Nagata, E, Nakanishi, N, Mori, T, Seki, S, Okamoto, K, Moriai, O, Emura, Y, Fukuda, T, Date, H, Kawakami, S, Ueyama, Y, Fudo, T, Imaizumi, M, Ogawa, T, Take, S, Ikeda, H, Nishioka, H, Sakamoto, N, Ikeoka, K, Wakaki, N, Doiuchi, J, Kira, T, Tada, M, Tsuzaki, K, Miura, N, Fujisawa, Y, Furumoto, W, Fujisawa, A, Nakamura, R, Komatsu, H, Fujiki, R, Kawano, S, Nishizawa, K, Kato, Y, Azuma, J, Yasui, K, Amano, T, Sekine, Y, Honzawa, T, Koshibu, Y, Sakamoto, Y, Seta, Y, Miyaguchi, S, Morishita, K, Samejima, Y, Sasaki, T, Iseki, F, Kobayashi, T, Kano, H, Kim, J, Yamaguchi, H, Takagi, Y, Onuki Pearce, Y, Suzuki, Y, Fukui, T, Nakayama, T, Kanai, H, Kawano, Y, Ino, T, Miyoshi, H, Miyamoto, Y, Shigekiyo, M, Ono, S, Okamoto, Y, Ubukata, S, Kodera, K, Oriuchi, T, Matsumoto, N, Inagaki, K, Iseki, A, Goda, T, Katsuki, T, Sato, A, Mori, E, Tsubokura, T, Shudo, H, Fujimoto, S, Katsuya, T, Furukawa, Y, Narumi, J, Owari, M, Inakura, T, Anno, T, Shirakawa, K, Keong Ching Toon Wei Lim, C, Foo, D, Wong, K, Yuyang, T, Oh Hui Nam Park, S, Kim, W, Lee, H, Jang, S, Hyeok Kim, D, Ryu, D, Shim, J, Kim, D, Ju Choi, D, Seog Oh, Y, Cho, M, Kim, H, Jeon, H, Shin, D, Weon Park, S, Ki Park, H, Han, S, Hoon Sung, J, Park, H, Nam, G, Keun On, Y, Euy Lim, H, Kwak, J, Cha, T, Jong Hong, T, Hoon Park, S, Han Yoon, J, Kim, N, Kim, K, Chun Jung, B, Hwang, G, Kim, C, Rungaramsin Peerapat Katekangplu, S, Khunrong, P, Bunyapipat, T, Wongcharoen, W, Kaewsuwanna, P, Siriwattana, K, Tiyanon, W, Pattanaprichakul, S, Likittanasombat, K, Cholsaringkarl, D, Boonyapisit, W, Cheewatanakornkul, S, Silaruks, S, Hutayanon, P, Chawanadelert, S, Chattranukulchai, P, Chatlaong, B, Santanakorn, Y, Kanokphatcharakun, K, Mongkolwongroj, P, Jai-Aue, S, Komson, O, Altun Ali Aydinlar, A, Topsakal, R, Ongen, Z, Acikel, S, Yildiray Sahin, D, Yilmaz, O, Birhan Yilmaz, M, Pekdemir, H, Demir, M, Sucu, M, Sahiner, L, Ersanli, M, Okuyan, E, Aras, D, Rolandi Adrian Cesar Ingaramo, F, Alberto Sambadaro, G, Fernandez Caputi, V, Luciardi, H, Graciela Berman, S, Dragotto, P, Javier Kleiban, A, Centurion, N, Andres Ahuad Guerrero, R, Adalberto Di Paola, L, Dario Dran, R, Egido, J, Jose Fosco, M, Alfredo Sinisi, V, Rodolfo Cartasegna, L, Gomez Vilamajo, O, Luis Ramos, J, Sassone, S, Zapata, G, Conde, D, Giacomi, G, Alfredo Fernandez, A, Alberto Berli, M, Ferroni, F, Celestino Sobral Filho Jefferson Jaber, D, Vidal Armaganijan, L, Roberto Frack Costantini, C, Steffens, A, Kunz Sebba Barroso de Souzaem, W, David de Souza Neto, J, Márcio Ribeiro, J, Silveira Teixeira, M, Rossi, P, Pires, L, Moreira, D, Carlos Moura Jorge, J, Menezes Lorga Filho, A, Bodanese, L, Westerlund Montera, M, Henrique Del Carlo, C, Abdalla Saad, J, Augusto Alves da Costa, F, Lopes, R, Roberto de Araújo, G, Roberto Manenti, E, Francisco Kerr Saraiva, J, Carlos Ferreira Braga, J, Negri, A, Moncada, C, Precoma, D, Roquette, F, Reis, G, Álvaro Ramos Filho, R, Lanna Figueiredo, E, Vieira Botelho, R, Munhoz da Fontoura Tavares, C, Carlos Finimundi, H, Kochi, A, Cássio Broilo França, C, Alban, F, Bernardo Aranha Rosito, G, Batista de Moura Xavier Moraes Junior, J, Tadeu Tumelero, R, Maia, L, Simões de Almeida, R, Carter do Carmo Borges, N, Gustavo Gomes Ferreira, L, Corbalán Benjamin Aleck Joseh Stockins Fernandez, R, Montecinos, H, Lanas, F, Larico Gómez, M, Astudillo, C, Conejeros, C, Marin Cuevas, P, Forero, A, Bugueño Gutiérrez, C, Aguilar, J, Potthoff Cardenas, S, Eggers, G, Houzvic, C, Rey, C, Arriagada, G, Charme Vilches, G, Jerjes Sanchez Diaz Jesus Jaime Illescas Diaz, C, Leal Cantu, R, Guadalupe Ramos Zavala, M, Cabrera Jardines, R, Espinola Zavaleta, N, Lopez Rosas, E, Antonio Llamas Esperón, G, Pozas, G, Cardona Muñoz, E, Matadamas Hernandez, N, Leyva Rendon, A, Garcia Hernandez, N, de los Rios Ibarra, M, Ramon Virgen Carrillo, L, Lopez Villezca, D, Hernandez Herrera, C, Jose Lopez Prieto, J, Gaona Rodriguez, R, Villeda Espinosa, E, Flores Martinez, D, Velasco Barcena, J, Fierro Fierro, O, Rodriguez Briones, I, Luis Leiva Pons, J, Alvarez Lopez, H, Olvera Ruiz, R, Gerardo Cantu Brito, C, Julian Jose Roberto Chuquiure Valenzuela, E, Reyes Sanchez, R, Esteban Bazzoni Ruiz, A, Martin Lopez Ruiz, O, Arriaga Nava, R, David Morales Cerda, J, Fajardo Campos, P, Benavides Gonzalez, M, Brodmann Kurt Lenz, M, Hagn, C, Foechterle, J, Drexel, H, Huber, K, Podczeck-Schweighofer, A, Winkler, M, Schneeweiss, B, Gegenhuber, A, Lang, W, Eichinger-Hasenauer, S, Kaserer, P, Sykora, J, Rasch, H, Strohmer, B, Capiau Geert Vervoort, L, Wollaert, B, Hollanders, G, Vercammen, J, Faes, D, Balthazar, Y, Delforge, M, Xhaet, O, Striekwold, H, Thoeng, J, Hermans, K, Mairesse, G, Anné, W, Blankoff, I, Beutels, M, Verstraete, S, Vandergoten, P, Purnode, P, Godart, P, Boussy, T, Desfontaines, P, Heyse, A, Voet, J, De Wolf, A, Zidkova Petr Jansky, E, Spacek, R, Machova, V, Ludka, O, Olsr, J, Kotik, L, Racz, B, Ferkl, R, Hubac, J, Kotik, I, Monhart, Z, Burianova, H, Jerabek, O, Pisova, J, Petrova, I, Dedek, V, Honkova, M, Podrazil, P, Reichert, P, Spinar, J, Novak, M, Durdil, V, Plocova, K, Lastuvka, J, Nielsen Steen Husted, J, Dominguez, H, Hintze, U, Rasmussen, S, Sygehus, N, Bremmelgaard, A, Markenvard, J, Børger, J, Solgaard, J, Eriksen, E, Løkkegaard, T, Bruun, M, Mertz, J, Schou, M, Olsen, M, Raatikainen Carmela Viitanen, P, Paganelli Joël Ohayon, F, Casassus, F, Galinier, M, Gottwalles, Y, Loiselet, P, Muller, J, Bassel Koujan, M, Marquand, A, Destrac, S, Piot, O, Delarche, N, Cebron, J, Guenoun, M, Guedj-Meynier, D, Lokesh, A, Zuber, M, Amarenco, P, Ellie, E, Kadouch, J, Fournier, P, Huberman, J, Lemaire, N, Rodier, G, Vandamme, X, Sibon, I, Neau, J, Hélène Mahagne, M, Mielot, A, Bonnefoy, M, Churet, J, Navarre, V, Sellem, F, Monniot, G, Boyes, J, Doucet, B, Martelet, M, Obadia, D, Crousillat, B, Mouallem, J, Bearez, E, Philippe Brugnaux, J, Fedorowsky, A, Nazeyrollas, P, Berneau, J, Chemin, F, Schellong Harald Darius, S, Koeniger, G, Kopf, A, Gerbaulet, U, Kellner, B, Schaefer, T, Purr, J, Eißfeller, E, Zauzig, H, Riegel, P, Axthelm, C, Heinz, G, Menke, H, Pustelnik, A, Zutz, S, Eder, W, Rehling, G, Glatzel, D, Ludwig, N, Sandow, P, Wiswedel, H, Wildenauer, C, Schoen, S, Schwarz, T, Babyesiza, A, Kropp, M, Zimny, H, Kahl, F, Caspar, A, Omankowsky, S, Laessig, T, Hartmann, H, Lehmann, G, Bindig, H, Hergdt, G, Reimer, D, Hauk, J, Michel, H, Werner Erdle, P, Dorsch, W, Dshabrailov, J, Rapp, K, Vormann, R, Mueller, T, Mayer, P, Horstmeier, U, Eissing, V, Hey, H, Leuchtgens, H, Lilienweiss, V, Mueller, H, Schubert, C, Lauer, H, Buchner, T, Brauer, G, Kamin, S, Mueller, K, Baumbach, S, Abdel-Qader, M, Ebert, H, Schwencke, C, Bernhardt, P, Karolyi, L, Sievers, B, Haverkamp, W, Roehnisch, J, Vertes Gabor Szantai, A, Matoltsy, A, Kanakaridisz, N, Boda, Z, Kis, E, Gaszner, B, Juhasz, F, Juhasz, G, Kancz, S, Laszlo, Z, May, Z, Merkely, B, Noori, E, Habon, T, Polgar, P, Szalai, G, Vangel, S, Nagy, A, Engelthaler, G, Ferenczi, J, Egyutt, M, Martini Leone Maria Cristina, G, Tiraferri, E, Santoro, R, Testa, S, Di Minno, G, Moia, M, Maria Caimi, T, Tessitori, M, Cappelli, R, Poli, D, Quintavalla, R, Cosmi, F, Fanelli, R, Oriana, V, Reggio, R, Santi, R, Pancaldi, L, De Cristofaro, R, Guazzaloca, G, De Blasio, A, Salerno Uriate, J, Lillo, F, Maria Pogliani, E, Bilo, G, Accogli, M, Mariani, A, Feola, M, Raisaro, A, Fattore, L, Mauric, A, Germini, F, Tedeschi, L, Settimi, M, Nicoli, S, Ricciarini, P, Argena, A, Ronchini, P, Bulla, C, Tradati, F, Volpe, M, D’Avino, M, Grazia Bongiorni, M, Severi, S, Capucci, A, Lodigiani, C, Salomone, E, Serviddio, G, Tondo, C, Golino, P, Mazzone, C, Iacopino, S, Ruiter, H, Lucassen, A, Adriaansen, H, Bongaerts, M, Pieterse, M, van Guldener, C, Herrman, J, Nierop, S, Hoogslag, P, Hermans, W, Groenemeijer, B, Terpstra, W, Buiks, C, Boersma, L, Berge Per Anton Sirnes, E, Gjertsen, E, Hole, T, Erga, K, Hallaråker, A, Skjelvan, G, Østrem, A, Ghezai, B, Svilaas, A, Christersson, P, Øien, T, Høegh Henrichsen, S, Erik Otterstad, J, Berg-Johansen, J, Stepinska Andrzej Gieroba, J, Biedrzycka, M, Ogorek, M, Wozakowska-Kaplon, B, Loboz-Grudzien, K, Jaroslaw, Supinski, W, Kuzniar, J, Zaluska, R, Hiczkiewicz, J, Swiatkowska-Byczynska, L, Kucharski, L, Gruchala, M, Minc, P, Olszewski, M, Kania, G, Krzciuk, M, Lajkowski, Z, Ostrowska-Pomian, B, Lewczuk, J, Zinka, E, Karczmarczyk, A, Chmielnicka-Pruszczynska, M, Wozniak-Skowerska, I, Opolski, G, Bronisz, M, Glanowska, G, Ruszkowski, P, Skonieczny, G, Sciborski, R, Okopien, B, Kukla, P, Galbas, K, Cymerman, K, Jurowiecki, J, Miekus, P, Myszka, W, Mazur, S, Lysek, R, Baszak, J, Rusicka-Piekarz, T, Raczak, G, Domanska, E, Nessler, J, Lesnik, J, Eltishcheva Roman Libis, V, Kamalov, G, Belenky, D, Egorova, L, Khokhlov, A, Yakupov, E, Zateyshchikov, D, Barbarash, O, Miller, O, Mazur, E, Zrazhevskiy, K, Novikova, T, Moiseeva, Y, Polkanova, E, Sobolev, K, Rossovskaya, M, Shapovalova, Y, Kolesnikova, A, Nikolaev, K, Zemlianskaia, O, Zateyshchikova, A, Kostenko, V, Popov, S, Poltavskaya, M, Edin, A, Aleksandrova Oksana Drapkina, E, Vishnevsky, A, Nagibovich, O, Chizhov, P, Rachkova, S, Sergeev, M, Kurylo, B, Ushakov, A, Vinolas Pere Alvarez Garcia, X, Fernanda Lopez Fernandez, M, Tercedor Sanchez, L, Tranche Iparraguirre, S, Toran Monserrat, P, Marquez Contreras, E, Isart Rafecas, J, Motero Carrasco, J, Garcia Pavia, P, Gomez Pajuelo, C, Miguel Rincon Diaz, L, Fernando Iglesias Alonso, L, Grande Ruiz, A, Merce Klein, J, Ramon Gonzalez Juanatey, J, Monte Collado, I, Palacin Piquero, H, Brotons Cuixart, C, Fernandez Escobar, E, i Llibre, J, Corros Vicente, C, Vida Gutierrez, M, Epelde Gonzalo, F, Alexandre Almeida Fernandez, C, Martinez Navarro, E, Jose Montero Alia, J, Barreda Gonzalez, M, Angels Moleiro Oliva, M, Iglesias Sanmartin, J, Jimenez Gonzalez, M, del Mar Rodriguez Alvarez, M, Herreros Melenchon, J, Ripoll Vera, T, Jimenez Navarro, M, Vazquez Caamano, M, Fe Arcocha Torres, M, Marcos Gomez, G, Iniguez Romo, A, Angel Prieto Diaz, M, Rosenqvist Alexander Wirdby, M, Centrumkliniken, Lindén, J, Henriksson, K, Elmersson, M, Egilsson, A, Börjesson, U, Svärd, G, Liu, B, Lindh, A, Olsson, L, Gustavsson, M, Andersson, L, Benson, L, Bothin, C, Hajimirsadeghi, A, Martinsson, B, Ericsson, M, Ohlsson, Å, Lindvall, H, Svensson, P, Thörne, K, Händel, H, Platonov, P, Bernsten, F, Timberg, I, Crisby, M, Karlsson, J, Andersson, A, Malmqvist, L, Engdahl, J, Thulin, J, Hot-Bjelak, A, Jensen, S, Stalby, P, Steffel Johann Debrunner, J, Beer, J, Shah, D, Rudyk Vira Tseluyko, I, Karpenko, O, Zhurba, S, Kraiz, I, Parkhomenko, O, Kupnovytska, I, Seredyuk, N, Mostovoy, Y, Ushakov, O, Koval, O, Kovalskiy, I, Svyshchenko, Y, Sychov, O, Stanislavchuk, M, Yagensky, A, Tykhonova, S, Fushtey, I, Murdoch Naresh Chauhan, W, Goodwin, D, Lumley, L, Patel, R, Saunders, P, Wong, B, Cameron, A, Patel, N, Jhittay, P, Ross, A, Kainth, M, Ladha, K, Douglas, K, Pickavance, G, Mcdonnell, J, Handscombe, L, Gooding, T, Wagner, H, Cumberlidge, Bradshaw, C, Bromham, C, Jones, K, Suryani, S, Coates, R, Sarai, B, Willcock, W, Sircar, S, Cairns, J, Gilliand, A, Bilas, R, Strieder, E, Hutchinson, P, Wakeman, A, Stokes, M, Kirby, G, Vishwanathan, B, Bird, N, Evans, P, Clark, M, Bisatt, J, Litchfield, J, Fisher, E, Fooks, T, Kelsall, R, Paul, N, Alborough, E, Aziz, M, Ramesh, C, Wilson, P, Franklin, S, Fairhead, S, Thompson, J, Chowan, H, Taylor, G, Tragen, D, Parfitt, M, Seamark, C, Paul, C, Richardson, M, Jefferies, A, Sharp, H, Jones, H, Giles, C, Bramley, M, Williams, P, Aldegather, J, Wetherell, S, Lumb, W, Scouller, F, Macey, N, Rogers, S, Stipp, Y, West, R, Pinney, P, Wadeson, P, Matthews, J, Pandya, P, Gallagher, A, Railton, T, Davies, E, Mcclure, J, Jacobs, M, Hutton, C, Thompson, R, Sinha, B, Butter, K, Barrow, S, Little, H, Russell, D, Choudhary, U, Haq, I, Ainsworth, P, Jones, C, Weeks, P, Eden, J, Gibbons, L, Glencross, J, Macleod, A, Poland, K, Mulolland, C, Warke, A, Conn, P, Burns, D, Smith, R, Kamath, R, Webster, J, Hodgins, I, Vercoe, S, Roome, P, Pinnock, H, Patel, J, Ali, A, Hart, N, Davies, R, De-Sousa, N, Neden, C, Danielsen, M, Sharma, P, Galloway, S, Hawkins, C, Oliver, R, Aylward, M, Pattni, M, Irvine, G, Ahmad, S, Rothwell, C, Choudhary, F, Khalaque, S, Short, S, Peters, S, Coulson, W, Roberts, N, Butler Steven Coates, A, Ward, B, Jackson, D, Walton, S, Shepherd, D, Wong, T, Boon, M, Deacon, M, Cornelius, D, Davies, S, Frankel, B, Hargreaves, N, Choi, H, Sumner, J, Myhill, T, Estifanos, S, Geatch, D, Wilkinson, J, Veale, R, Forshaw, K, Hirst, R, Zaman, K, Liley, C, Wastling, R, Mceleny, P, Beattie, A, Cooke, P, Wong, M, Pugsley, M, Dooldeniya, C, Rogers, G, Bennett, J, Jacobs, P, Muvva, R, Adam, M, Fox, R, Thomas, N, Cartwright, S, Reed, R, Randfield, S, A’Court, C, Flynn, A, Halpin, A, Dobson, S, Lomax, L, Nadaph, M, Munro, I, Goram, J, Stoddart, H, Simmons, P, Shewring, J, Bowen-Simpkins, E, Rickenbach, M, Blenkhorn Bhuwanendu Singh, A, Astridge, P, van Gaal, W, Abhayaratna, W, Thomson, P, Lehman, R, Kilian, J, Coulshed, D, Catanchin, A, Colquhoun, D, Kiat, H, Eccleston, D, French, J, Ayres, B, Blombery, P, Phan, T, Rogers, J, O’Donnell, D, Cheol Bae, S, Gibbs, H, Carroll, P, Starmer, G, Arstall, M, Binnekamp, M, Lee, A, Eikelboom Robert Luton, J, Gupta, M, Shekhar Pandey, A, Cheung, S, Leader, R, Beaudry, P, Ayala-Paredes, F, Berlingieri, J, Heath, J, Poirier, G, du Preez, M, Schweitzer, B, Nadeau, R, Dhillon, R, Hruczkowski, T, Lavoie, A, Parkash, R, Cha, J, Coutu, B, Macdonald, P, Ramjattan, B, Bonet, J, Vizel, S, Angaran, P, Fikry, S, Mowafy Azza Katta, A, Tawfik, M, Nawar, M, Sobhy, M, Kamal Abou Seif, S, Khairy, T, Abd El-Aziz, A, Taha, N, Reda, A, Elbahry, A, Setiha, M, Gamal El Din, M, Elkhadem, M, El-Etreby, A, Kettles Junaid Bayat, D, Siebert, H, Horak, A, Kelfkens, Y, Garda, R, Pillay, T, Guerra, M, van Zyl, L, Theron, H, Murray, A, Louw, R, Greyling, D, Mntla, P, Ismail, S, Ahmed, F, Engelbrecht, J, Maharajh, S, Oosthuysen, W, Loghdey, R, Ueckermann, V, AlAl Mahmeed AbdullahNaeemi, W, Yousef, G, Bazargani, N, Alomairi, M, Maruthanayagam, R, Singh, R, Naguib, A, Ibrahim, M, Agrawal, A, Nathani, M, Esheiba, E, Wassef, A, Gupta, R, Cox Scott Beach, M, Duffy, P, Falkowski, S, Ferrick, K, Franco, M, Michael Kutayli, W, Quick, A, Sharma, N, Wilson, V, Miller, S, Alberts, M, Blumberg, E, Canosa, R, Gutowski, T, Ison, R, Garcia, J, Mullen, P, Noveck, H, Rama, P, Reddy, R, Williams, M, Nishijima, D, Ferdinand, K, Haque, I, Mendelson, R, Pitta, S, Theodoro, D, Treasure, C, Moustafa, M, Cader, C, Pharr, W, Oropallo, A, Platt, G, Gujral, J, Welker, J, Koura, F, Haas, Sylvia, Camm, John A, Harald, Darius, Steffel, Jan, Virdone, Saverio, Pieper, Karen, Brodmann, Marianne, Schellong, Sebastian, Misselwitz, Frank, Kayani, Gloria, Ajay K. Kakkar, Jean-Pierre Bassand, A. John Camm, David A. Fitzmaurice, Keith A. A. Fox, Bernard J. Gersh, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Karen S. Pieper, Alexander G. G. Turpie, Martin van Eickels, Freek W. A. Verheugt, Keith A. A. Fox Bernard J. Gersh, Hector Lucas Luciardi Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, John Eikelboom, Ramon Corbalan, Zhi-Cheng Jing, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, Dayi Hu Kangning Chen, Yusheng Zhao, Huaiqin Zhang, Jiyan Chen, Shiping Cao, Daowen Wang, Yuejin Yang, Weihua Li, Hui Li, Yuehui Yin, Guizhou Tao, Ping Yang, Yingmin Chen, Shenghu He, Yong Wang, Guosheng Fu, Xin Li, Tongguo Wu, Xiaoshu Cheng, Xiaowei Yan, Ruiping Zhao, Moshui Chen, Longgen Xiong, Ping Chen, Yang Jiao, Ying Guo, Li Xue, Zhiming Yang, Praveen Jadhavm Raghava Sarma, Govind Kulkarni, Prakash Chandwani, Rasesh Atulbhai Pothiwala, Mohanan Padinhare Purayil, Kamaldeep Chawla, Veerappa Annasaheb Kothiwale, Bagirath Raghuraman, Vinod Madan Vijan, Jitendra Sawhney, Ganapathi Bantwal, Aziz Khan, Ramdhan Meena, Manojkumar Chopada, Sunitha Abraham, Vikas Bisne, Govindan Vijayaraghavan, Debabrata Roy, Rajashekhar Durgaprasad, A. G. Ravi Shankar, Sunil Kumar, Dinesh Jain, Kartikeya Bhargava, Vinay Kumar, Udigala Madappa Nagamalesh, Rajeeve Kumar Rajput, Yukihiro Koretsune Seishu Kanamori, Kenichi Yamamoto, Koichiro Kumagai, Yosuke Katsuda, Keiki Yoshida, Fumitoshi Toyota, Yuji Mizuno, Ikuo Misumi, Hiroo Noguchi, Shinichi Ando, Tetsuro Suetsugu, Masahiro Minamoto, Hiroyuki Oda, Susumu Adachi, Kei Chiba, Hiroaki Norita, Makoto Tsuruta, Takeshi Koyanagi, Kunihiko Yamamoto, Hiroshi Ando, Takayuki Higashi, Megumi Okada, Shiro Azakami, Shinichiro Komaki, Kenshi Kumeda, Takashi Murayama, Jun Matsumura, Yurika Oba, Ryuji Sonoda, Kazuo Goto, Kotaro Minoda, Yoshikuni Haraguchi, Hisakazu Suefuji, Hiroo Miyagi, Hitoshi Kato, Tsugihiro Nakamura, Tadashi Nakamura, Hidekazu Nandate, Ryuji Zaitsu, Yoshihisa Fujiura, Akira Yoshimura, Hiroyuki Numata, Jun Ogawa, Yasuyuki Kamogawa, Kinshiro Murakami, Yutaka Wakasa, Masanori Yamasawa, Hiromitsu Maekawa, Sumihisa Abe, Hajime Kihara, Satoru Tsunoda, Katsumi Saito, Hiroki Tachibana, Ichiro Oba, Takashi Kuwahata, Satoshi Higa, Masamichi Gushiken, Takuma Eto, Hidetoshi Chibana, Kazuaki Fujisawa, Yuhei Shiga, Hirokuni Sumi, Toshihisa Nagatomo, Yoshihiko Atsuchi, Toshiro Nagoshi, Kazuhisa Sanno, Fumihiro Hoshino, Naoto Yokota, Masahiro Kameko, Toshifumi Tabuchi, Munesumi Ishizawa, Yoshitake Fujiura, Daisuke Ikeda, Taku Seto, Tetsu Iwao, Norio Ishioka, Koichi Oshiro, Keizo Tsuchida, Yutaka Hatori, Motoshi Takeuchi, Hiroto Takezawa, Shinjiro Nagano, Masaaki Iwaki, Yuichiro Nakamura, Naomasa Miyamoto, Toshifumi Taguchi, Ko Ashida, Naoto Yoshizawa, Jun Agata, Seishiro Matsukawa, Osamu Arasaki, Shuji Fukuoka, Hirofumi Murakami, Kazuya Mishima, Yoshiki Hata, Ichiro Sakuma, Kotaro Obunai, Ichiro Takamura, Mitsuyuki Akutsu, Toshihide Unoki, Yoshinori Go, Makoto Ikemura, Shoji Morii, Shigeru Marusaki, Hideo Doi, Mitsuru Tanaka, Takaaki Kusumoto, Shigeo Kakinoki, Chiga Ogurusu, Kazuya Murata, Masaki Shimoyama, Masami Nakatsuka, Yutaka Kitami, Yoichi Nakamura, Hiroshi Oda, Rikimaru Oyama, Masato Ageta, Teruaki Mita, Kazuhiko Nagao, Takafumi Mito, Junichi Minami, Mitsunori Abe, Masako Fujii, Makoto Okawa, Tsuneo Fujito, Toshiya Taniguchi, Tenei Ko, Hiroshi Kubo, Mizuho Imamaki, Masahiro Akiyama, Takashi Ueda, Hironori Odakura, Masahiko Inagaki, Yoshiki Katsube, Atsuyuki Nakata, Shinobu Tomimoto, Mitsuhiro Shibuya, Masayuki Nakano, Kenichiro Ito, Masahiro Matsuta, Motoyuki Ishiguro, Taro Minagawa, Masamichi Wada, Hiroaki Mukawa, Masato Mizuguchi, Fumio Okuda, Teruaki Kimura, Kuniaki Taga, Masaaki Techigawara, Morio Igarashi, Hiroshi Watanabe, Toshihiko Seo, Shinya Hiramitsu, Hiroaki Hosokawa, Mitsumoto Hoshiai, Michitaka Hibino, Koichi Miyagawa, Hideki Horie, Nobuyoshi Sugishita, Yukio Shiga, Akira Soma, Kazuo Neya, Tetsuro Yoshida, Kunio Akahane, Sen Adachi, Chiei Takanaka, Saori Matsui, Hirofumi Kanda, Masanori Kaneko, Shiro Nagasaka, Atsushi Taguchi, Shuta Toru, Kazuyuki Saito, Akiko Miyashita, Hiroki Sasaguri, Jin Nariyama, Taketo Hatsuno, Takash Iwase, Kazuki Sato, Kazuya Kawai, Tomobumi Kotani, Tsuyoshi Tsuji, Hirosumi Sakai, Kiyoshi Nishino, Kenichi Ikeda, Kazuo Maeda, Tomohiro Shinozuka, Takeshi Inoue, Koichi Kawakami, Hiromichi Kitazumi, Tsutomu Takagi, Mamoru Hamaoka, Jisho Kojima, Akitoshi Sasaki, Yoshihiro Tsuchiya, Tetsuo Betsuyaku, Koji Higuchi, Masaaki Honda, Koichi Hasegawa, Takao Baba, Kazuaki Mineoi, Toshihiko Koeda, Kunihiko Hirasawa, Toshihide Kumazaki, Akira Nakagomi, Eiji Otaki, Takashi Shindo, Hiroyoshi Hirayama, Chikako Sugimoto, Takashi Yamagishi, Ichiro Mizuguchi, Kazunori Sezaki, Isamu Niwa, Ken Takenaka, Osamu Iiji, Koichi Taya, Hitoshi Kitazawa, samu Ueda, Hirokazu Kakuda, Takuya Ono, Seizo Oriso, Junya Kamata, Toshihiko Nanke, Itaru Maeda, Yoshifusa Matsuura, Hiroki Teragawa, Yasuyuki Maruyama, Kazuo Takei, Hajime Horie, Tetsutaro Kito, Hiroshi Asano, Koji Matsushita, Masaichi Nakamura, Takashi Washizuka, Tomoki Yoshida, Masato Sawano, Shinichi Arima, Hidekazu Arai, Hisanori Shinohara, Hiroyuki Takai, Nobufusa Furukawa, Akira Ota, Kentaro Yamamoto, Kenji Aoki, Taku Yamamoto, Takeaki Kasai, Shunji Suzuki, Shu Suzuki, Nitaro Shibata, Masayuki Watanabe, Yosuke Nishihata, Toru Arino, Masaki Okuyama, Tetsushi Wakiyama, Tomoko Kato, Yasuo Sasagawa, Takeshi Tana, Yoshihito Hayashi, Shinichi Hirota, Yukihiko Abe, Yoshihiro Saito, Hirohide Uchiyama, Hiroshi Takeda, Hiroshi Ono, Shuichi Tohyo, Naoto Hanazono, Seiichi Miyajima, Hisashi Shimono, Takuma Aoyama, Yasunobu Shozawa, Yawara Niijima, Osamu Murai, Hideko Inaba, Katsumasa Nomura, Masatsugu Nozoe, Kazuo Suzuki, Toshiyuki Furukawa, Toshihiko Shiraiwa, Nobuhisa Ito, Shunichi Nagai, Kiyoharu Sato, Shiro Nakahara, Yujin Shimoyama, Naoko Ohara, Teruhiko Kozuka, Hideaki Okita, Masato Endo, Tsutomu Goto, Makoto Hirose, Emiko Nagata, Noriyuki Nakanishi, Toshizumi Mori, Shuichi Seki, Katsuhiro Okamoto, Osamu Moriai, Yoko Emura, Tsuyoshi Fukuda, Haruhiko Date, Shuichi Kawakami, Sho Nagai, Yuya Ueyama, Tetsuro Fudo, Mitsuru Imaizumi, Takuo Ogawa, Shunsuke Take, Hideo Ikeda, Hiroaki Nishioka, Norihiko Sakamoto, Kiyomitsu Ikeoka, Nobuo Wakaki, Masatake Abe, Junji Doiuchi, Tetsuya Kira, Masato Tada, Ken Tsuzaki, Naoya Miura, Yasuaki Fujisawa, Wataru Furumoto, Susumu Suzuki, Akinori Fujisawa, Ryosai Nakamura, Hiroyasu Komatsu, Rei Fujiki, Shuichi Kawano, Keijiro Nishizawa, Yoji Kato, Junya Azuma, Kiyoshi Yasui, Toshio Amano, Yasuhiro Sekine, Tatsuo Honzawa, Yuichiro Koshibu, Yasuhide Sakamoto, Yukihiro Seta, Shingo Miyaguchi, Kojuro Morishita, Yasuko Samejima, Toyoshi Sasaki, Fumiko Iseki, Toshiyuki Kobayashi, Hiroshi Kano, Jaeyoung Kim, Hiroshi Yamaguchi, Yoichi Takagi, Yoko Onuki Pearce, Yasuyuki Suzuki, Takayuki Fukui, Toru Nakayama, Hideaki Kanai, Yoshiyuki Kawano, Tetsuji Ino, Hironori Miyoshi, Yasufumi Miyamoto, Masahito Shigekiyo, Shimato Ono, Yutaka Okamoto, Satoshi Ubukata, Kojiro Kodera, Tatsuo Oriuchi, Naoki Matsumoto, Koichi Inagaki, Atsushi Iseki, Tomohiro Yoshida, Toshihiro Goda, Tsukasa Katsuki, Atsushi Sato, Etsuo Mori, Toshio Tsubokura, Hiroshi Shudo, Shunichi Fujimoto, Tomohiro Katsuya, Yoshiyuki Furukawa, Hiroshi Hosokawa, Jun Narumi, Kiichiro Yamamoto, Masaki Owari, Takuya Inakura, Takafumi Anno, Kazuyuki Shirakawa, Chi Keong Ching Toon Wei Lim, David Foo, Kelvin Wong, Tan Yuyang, Seil Oh Hui Nam Park, Woo-Shik Kim, HyeYoung Lee, Sung-Won Jang, Dae Hyeok Kim, Jun Kim, DongRyeol Ryu, Jaemin Shim, Dae-Kyeong Kim, Dong Ju Choi, Yong Seog Oh, Myeong-Chan Cho, Hack-Lyoung Kim, Hui-Kyung Jeon, Dong-Gu Shin, Sang Weon Park, Hoon Ki Park, Sang-Jin Han, Jung Hoon Sung, Hyung-Wook Park, Gi-Byoung Nam, Young Keun On, Hong Euy Lim, JaeJin Kwak, Tae-Joon Cha, Taek Jong Hong, Seong Hoon Park, Jung Han Yoon, Nam-Ho Kim, Kee-Sik Kim, Byung Chun Jung, Gyo-Seung Hwang, Chong-Jin Kim, Sakda Rungaramsin Peerapat Katekangplu, Porames Khunrong, Thanita Bunyapipat, Wanwarang Wongcharoen, Pinij Kaewsuwanna, Khanchai Siriwattana, Waraporn Tiyanon, Supalerk Pattanaprichakul, Khanchit Likittanasombat, Doungrat Cholsaringkarl, Warangkana Boonyapisit, Sirichai Cheewatanakornkul, Songkwan Silaruks, Pisit Hutayanon, Seksan Chawanadelert, Pairoj Chattranukulchai, Boonsert Chatlaong, Yingsak Santanakorn, Khompiya Kanokphatcharakun, Piya Mongkolwongroj, Sasivimon Jai-Aue, Ongkarn Komson, Armagan Altun Ali Aydinlar, Ramazan Topsakal, Zeki Ongen, Sadik Acikel, Durmus Yildiray Sahin, Ozcan Yilmaz, Mehmet Birhan Yilmaz, Hasan Pekdemir, Mesut Demir, Murat Sucu, Levent Sahiner, Murat Ersanli, Ertugrul Okuyan, Dursun Aras, Florencia Rolandi Adrian Cesar Ingaramo, Gustavo Alberto Sambadaro, Vanina Fernandez Caputi, Hector Luciardi, Sofia Graciela Berman, Pablo Dragotto, Andres Javier Kleiban, Nestor Centurion, Rodolfo Andres Ahuad Guerrero, Leonel Adalberto Di Paola, Ricardo Dario Dran, Javier Egido, Matias Jose Fosco, Victor Alfredo Sinisi, Luis Rodolfo Cartasegna, Oscar Gomez Vilamajo, Jose Luis Ramos, Sonia Sassone, Gerardo Zapata, Diego Conde, Guillermo Giacomi, Alberto Alfredo Fernandez, Mario Alberto Berli, Fabian Ferroni, Dário Celestino Sobral Filho Jefferson Jaber, Luciana Vidal Armaganijan, Costantino Roberto Frack Costantini, André Steffens, Weimar Kunz Sebba Barroso de Souzaem, João David de Souza Neto, José Márcio Ribeiro, Marcelo Silveira Teixeira, Paulo Rossi, Leonardo Pires, Daniel Moreira, José Carlos Moura Jorge, Adalberto Menezes Lorga Filho, Luiz Bodanese, Marcelo Westerlund Montera, Carlos Henrique Del Carlo, Jamil Abdalla Saad, Fernando Augusto Alves da Costa, Renato Lopes, Gilson Roberto de Araújo, Euler Roberto Manenti, Jose Francisco Kerr Saraiva, João Carlos Ferreira Braga, Alexandre Negri, Carlos Moncada, Dalton Precoma, Fernando Roquette, Gilmar Reis, Roberto Álvaro Ramos Filho, Estêvão Lanna Figueiredo, Roberto Vieira Botelho, Cláudio Munhoz da Fontoura Tavares, Helius Carlos Finimundi, Adriano Kochi, César Cássio Broilo França, Fábio Alban, Guido Bernardo Aranha Rosito, João Batista de Moura Xavier Moraes Junior, Rogério Tadeu Tumelero, Lilia Maia, Roberto Simões de Almeida, Ney Carter do Carmo Borges, Luís Gustavo Gomes Ferreira, Ramón Corbalán Benjamin Aleck Joseh Stockins Fernandez, Humberto Montecinos, Fernando Lanas, Martín Larico Gómez, Carlos Astudillo, Carlos Conejeros, Patricio Marin Cuevas, Alejandro Forero, Claudio Bugueño Gutiérrez, Juan Aguilar, Sergio Potthoff Cardenas, German Eggers, Cesar Houzvic, Carlos Rey, Germán Arriagada, Gustavo Charme Vilches, Carlos Jerjes Sanchez Diaz Jesus Jaime Illescas Diaz, Raul Leal Cantu, Maria Guadalupe Ramos Zavala, Ricardo Cabrera Jardines, Nilda Espinola Zavaleta, Enrique Lopez Rosas, Guillermo Antonio Llamas Esperón, Gerardo Pozas, Ernesto Cardona Muñoz, Norberto Matadamas Hernandez, Adolfo Leyva Rendon, Norberto Garcia Hernandez, Manuel de los Rios Ibarra, Luis Ramon Virgen Carrillo, David Lopez Villezca, Carlos Hernandez Herrera, Juan Jose Lopez Prieto, Rodolfo Gaona Rodriguez, Efrain Villeda Espinosa, David Flores Martinez, Jose Velasco Barcena, Omar Fierro Fierro, Ignacio Rodriguez Briones, Jose Luis Leiva Pons, Humberto Alvarez Lopez, Rafael Olvera Ruiz, Carlos Gerardo Cantu Brito, Eduardo Julian Jose Roberto Chuquiure Valenzuela, Roxana Reyes Sanchez, Alberto Esteban Bazzoni Ruiz, Oscar Martin Lopez Ruiz, Roberto Arriaga Nava, Jesus David Morales Cerda, Pedro Fajardo Campos, Mario Benavides Gonzalez, Marianne Brodmann Kurt Lenz, Claus Hagn, Johannes Foechterle, Heinz Drexel, Kurt Huber, Andrea Podczeck-Schweighofer, Michael Winkler, Bruno Schneeweiss, Alfons Gegenhuber, Wilfried Lang, Sabine Eichinger-Hasenauer, Peter Kaserer, Josef Sykora, Heribert Rasch, Bernhard Strohmer, Luc Capiau Geert Vervoort, Bart Wollaert, Geert Hollanders, Jan Vercammen, Dirk Faes, Yohan Balthazar, Marc Delforge, Olivier Xhaet, Harry Striekwold, John Thoeng, Kurt Hermans, Georges Mairesse, Wim Anné, Ivan Blankoff, Michel Beutels, Stefan Verstraete, Peter Vandergoten, Philippe Purnode, Pascal Godart, Tim Boussy, Philippe Desfontaines, Alex Heyse, Joeri Voet, Axel De Wolf, Eva Zidkova Petr Jansky, Rudolf Spacek, Vilma Machova, Ondrej Ludka, Josef Olsr, Lubos Kotik, Blazej Racz, Richard Ferkl, Jan Hubac, Ilja Kotik, Zdenek Monhart, Hana Burianova, Ondrej Jerabek, Jana Pisova, Iveta Petrova, Vratislav Dedek, Michaela Honkova, Petr Podrazil, Petr Reichert, Jindrich Spinar, Miroslav Novak, Vaclav Durdil, Katarina Plocova, Jiri Lastuvka, Jørn Nielsen Steen Husted, Helena Dominguez, Ulrik Hintze, Søren Rasmussen, Næstved Sygehus, Arne Bremmelgaard, John Markenvard, Jan Børger, Jorgen Solgaard, Ebbe Eriksen, Thomas Løkkegaard, Michael Bruun, Jacob Mertz, Morten Schou, Michael Olsen, Pekka Raatikainen Carmela Viitanen, Franck Paganelli Joël Ohayon, Frédéric Casassus, Michel Galinier, Yannick Gottwalles, Philippe Loiselet, Jean-Joseph Muller, Mohamed Bassel Koujan, André Marquand, Sylvain Destrac, Olivier Piot, Nicolas Delarche, Jean-Pierre Cebron, Maxime Guenoun, Dominique Guedj-Meynier, A. G. Lokesh, Mathieu Zuber, Pierre Amarenco, Emmanuel Ellie, James Kadouch, Pierre-Yves Fournier, Jean-Pierre Huberman, Nestor Lemaire, Gilles Rodier, Xavier Vandamme, Igor Sibon, Jean-Philippe Neau, Marie Hélène Mahagne, Antoine Mielot, Marc Bonnefoy, Jean-Baptiste Churet, Vincent Navarre, Frederic Sellem, Gilles Monniot, Jean-Paul Boyes, Bernard Doucet, Michel Martelet, Désiré Obadia, Bernard Crousillat, Joseph Mouallem, Etienne Bearez, Jean Philippe Brugnaux, Alain Fedorowsky, Pierre Nazeyrollas, Jean-Baptiste Berneau, Frédéric Chemin, Sebastien Schellong Harald Darius, Georg Koeniger, Andreas Kopf, Uwe Gerbaulet, Bernd-Thomas Kellner, Thomas Schaefer, Jan Purr, Enno Eißfeller, Heinz-Dieter Zauzig, Peter Riegel, Christoph Axthelm, Gerd-Ulrich Heinz, Holger Menke, Andreas Pustelnik, Stefan Zutz, Wolfgang Eder, Guenter Rehling, Dirk Glatzel, Norbert Ludwig, Petra Sandow, Henning Wiswedel, Cosmas Wildenauer, Steffen Schoen, Toralf Schwarz, Adyeri Babyesiza, Maximilian Kropp, Hans-Hermann Zimny, Friedhelm Kahl, Andreas Caspar, Sabine Omankowsky, Torsten Laessig, Hermann-Josef Hartmann, Gunter Lehmann, Hans-Walter Bindig, Gunter Hergdt, Dietrich Reimer, Joachim Hauk, Holger Michel, Praxis Dres. Werner Erdle, Wilfried Dorsch, Janna Dshabrailov, Karl-Albrecht Rapp, Reinhold Vormann, Thomas Mueller, Peter Mayer, Uwe Horstmeier, Volker Eissing, Heinz Hey, Heinz Leuchtgens, Volker Lilienweiss, Heiner Mueller, Christian Schubert, Herrmann Lauer, Thomas Buchner, Gunter Brauer, Susanne Kamin, Karsten Mueller, Sylvia Baumbach, Muwafeg Abdel-Qader, Hans-Holger Ebert, Carsten Schwencke, Peter Bernhardt, Laszlo Karolyi, Britta Sievers, Wilhelm Haverkamp, Jens-Uwe Roehnisch, Andras Vertes Gabor Szantai, Andras Matoltsy, Nikosz Kanakaridisz, Zoltan Boda, Erno Kis, Balazs Gaszner, Ferenc Juhasz, Gizella Juhasz, Sandor Kancz, Zoltan Laszlo, Zsolt May, Bela Merkely, Ebrahim Noori, Tamas Habon, Peter Polgar, Gabriella Szalai, Sandor Vangel, Andras Nagy, Gabriella Engelthaler, Judit Ferenczi, Mihaly Egyutt, Giuliana Martini Leone Maria Cristina, Eros Tiraferri, Rita Santoro, Sophie Testa, Giovanni Di Minno, Marco Moia, Teresa Maria Caimi, Maria Tessitori, Roberto Cappelli, Daniela Poli, Roberto Quintavalla, Franco Cosmi, Raffaele Fanelli, Vincenzo Oriana, Raffaele Reggio, Roberto Santi, Leonardo Pancaldi, Raimondo De Cristofaro, Giuliana Guazzaloca, Angelo De Blasio, Jorge Salerno Uriate, Flavia Lillo, Enrico Maria Pogliani, Grzegorz Bilo, Michele Accogli, Antonio Mariani, Mauro Feola, Arturo Raisaro, Luciano Fattore, Andrea Mauric, Fabrizio Germini, Luca Tedeschi, Maria Settimi, Sergio Nicoli, Paolo Ricciarini, Antonio Argena, Paolo Ronchini, Claudio Bulla, Filippo Tradati, Massimo Volpe, Maria D’Avino, Maria Grazia Bongiorni, Silva Severi, Alessandro Capucci, Corrado Lodigiani, Enrico Salomone, Gaetano Serviddio, Claudio Tondo, Paolo Golino, Carmine Mazzone, Saverio Iacopino, Hugo ten Cate J. H. Ruiter, Andreas Lucassen, Henk Adriaansen, Maarten Bongaerts, Mathijs Pieterse, Coen van Guldener, Johannes Herrman, S. H. K. P. R. Nierop, Pieter Hoogslag, Walter Hermans, B. E. Groenemeijer, W. Terpstra, Cees Buiks, L. V. A. Boersma, Eivind Berge Per Anton Sirnes, Erik Gjertsen, Torstein Hole, Knut Erga, Arne Hallaråker, Gunnar Skjelvan, Anders Østrem, Beraki Ghezai, Arne Svilaas, Peter Christersson, Torbjørn Øien, Svein Høegh Henrichsen, Jan Erik Otterstad, Jan Berg-Johansen, Janina Stepinska Andrzej Gieroba, Malgorzata Biedrzycka, Michal Ogorek, Beata Wozakowska-Kaplon, Krystyna Loboz-Grudzien, Wieslaw Supinski, Jerzy Kuzniar, Roman Zaluska, Jaroslaw Hiczkiewicz, Lucyna Swiatkowska-Byczynska, Lech Kucharski, Marcin Gruchala, Piotr Minc, Maciej Olszewski, Grzegorz Kania, Malgorzata Krzciuk, Zbigniew Lajkowski, Bozenna Ostrowska-Pomian, Jerzy Lewczuk, Elzbieta Zinka, Agnieszka Karczmarczyk, Malgorzata Chmielnicka-Pruszczynska, Iwona Wozniak-Skowerska, Grzegorz Opolski, Marek Bronisz, Marcin Ogorek, Grazyna Glanowska, Piotr Ruszkowski, Grzegorz Skonieczny, Ryszard Sciborski, Boguslaw Okopien, Piotr Kukla, Krzysztof Galbas, Krzysztof Cymerman, Jaroslaw Jurowiecki, Pawel Miekus, Waldemar Myszka, Stanislaw Mazur, Roman Lysek, Jacek Baszak, Teresa Rusicka-Piekarz, Grzegorz Raczak, Ewa Domanska, Jadwiga Nessler, Jozef Lesnik, Vera Eltishcheva Roman Libis, Gadel Kamalov, Dmitry Belenky, Liudmila Egorova, Alexander Khokhlov, Eduard Yakupov, Dmitry Zateyshchikov, Olga Barbarash, Olga Miller, Evgeniy Mazur, Konstantin Zrazhevskiy, Tatyana Novikova, Yulia Moiseeva, Elena Polkanova, Konstantin Sobolev, Maria Rossovskaya, Yulia Shapovalova, Alla Kolesnikova, Konstantin Nikolaev, Oksana Zemlianskaia, Anna Zateyshchikova, Victor Kostenko, Sergey Popov, Maria Poltavskaya, Anton Edin, Elena Aleksandrova Oksana Drapkina, Alexander Vishnevsky, Oleg Nagibovich, Petr Chizhov, Svetlana Rachkova, Mikhail Sergeev, Borys Kurylo, Alexey Ushakov, Xavier Vinolas Pere Alvarez Garcia, Maria Fernanda Lopez Fernandez, Luis Tercedor Sanchez, Salvador Tranche Iparraguirre, Pere Toran Monserrat, Emilio Marquez Contreras, Jordi Isart Rafecas, Juan Motero Carrasco, Pablo Garcia Pavia, Casimiro Gomez Pajuelo, Luis Miguel Rincon Diaz, Luis Fernando Iglesias Alonso, Angel Grande Ruiz, Jordi Merce Klein, Jose Ramon Gonzalez Juanatey, Ines Monte Collado, Herminia Palacin Piquero, Carles Brotons Cuixart, Esther Fernandez Escobar, Joan Bayo i Llibre, Cecilia Corros Vicente, Manuel Vida Gutierrez, Francisco Epelde Gonzalo, Carlos Alexandre Almeida Fernandez, Encarnacion Martinez Navarro, Juan Jose Montero Alia, Maria Barreda Gonzalez, Maria Angels Moleiro Oliva, Jose Iglesias Sanmartin, Mercedes Jimenez Gonzalez, Maria del Mar Rodriguez Alvarez, Juan Herreros Melenchon, Tomas Ripoll Vera, Manuel Jimenez Navarro, Maria Vazquez Caamano, Maria Fe Arcocha Torres, Gonzalo Marcos Gomez, Andres Iniguez Romo, Miguel Angel Prieto Diaz, Mårten Rosenqvist Alexander Wirdby, Jan Lindén, Kerstin Henriksson, Micael Elmersson, Arnor Egilsson, Ulf Börjesson, Gunnar Svärd, Bo Liu, Anders Lindh, Lars-Bertil Olsson, Mikael Gustavsson, Lars Andersson, Lars Benson, Claes Bothin, Ali Hajimirsadeghi, Björn Martinsson, Marianne Ericsson, Åke Ohlsson, Håkan Lindvall, Peter Svensson, Katarina Thörne, Hans Händel, Pyotr Platonov, Fredrik Bernsten, Ingar Timberg, Milita Crisby, Jan-Erik Karlsson, Agneta Andersson, Lennart Malmqvist, Johan Engdahl, Jörgen Thulin, Aida Hot-Bjelak, Steen Jensen, Per Stalby, Jan Steffel Johann Debrunner, Juerg H. Beer, Dipen Shah, Iurii Rudyk Vira Tseluyko, Oleksandr Karpenko, Svitlana Zhurba, Igor Kraiz, Oleksandr Parkhomenko, Iryna Kupnovytska, Nestor Seredyuk, Yuriy Mostovoy, Oleksiy Ushakov, Olena Koval, Igor Kovalskiy, Yevgeniya Svyshchenko, Oleg Sychov, Mykola Stanislavchuk, Andriy Yagensky, Susanna Tykhonova, Ivan Fushtey, Will Murdoch Naresh Chauhan, Daryl Goodwin, Louise Lumley, Ramila Patel, Philip Saunders, Bennett Wong, Alex Cameron, Niranjan Patel, P. Jhittay, Andrew Ross, M. S. Kainth, Karim Ladha, Kevin Douglas, Gill Pickavance, Joanna McDonnell, Laura Handscombe, Trevor Gooding, Helga Wagner, Colin Bradshaw, Catherine Bromham, Kevin Jones, Shoeb Suryani, Richard Coates, Bhupinder Sarai, W. Willcock, S. Sircar, John Cairns, A. Gilliand, Roman Bilas, E. Strieder, Peter Hutchinson, Anne Wakeman, Michael Stokes, Graham Kirby, Bhaskhar Vishwanathan, Nigel Bird, Paul Evans, M. Clark, John Bisatt, Jennifer Litchfield, E. Fisher, Tim Fooks, Richard Kelsall, Neil Paul, Elizabeth Alborough, Michael Aziz, C. Ramesh, Pete Wilson, Simon Franklin, Sue Fairhead, Julian Thompson, Hasan Chowan, Gary Taylor, Dawn Tragen, Matt Parfitt, Claire Seamark, Carolyn Paul, Mark Richardson, Angus Jefferies, Helen Sharp, Hywel Jones, Claire Giles, Matthew Bramley, Philip Williams, Jehad Aldegather, Simon Wetherell, William Lumb, Phil Evans, Frances Scouller, Neil Macey, Stephen Rogers, Yvette Stipp, Richard West, Philip Pinney, Paul Wadeson, John Matthews, Preeti Pandya, Andrew Gallagher, T. Railton, Emyr Davies, Jonathan McClure, Marc Jacobs, Claire Hutton, R. Thompson, Bijoy Sinha, Keith Butter, Susan Barrow, Helen Little, David Russell, Ulka Choudhary, Ikram Haq, Paul Ainsworth, Claire Jones, Phil Weeks, Jane Eden, Lisa Gibbons, Janet Glencross, Alison MacLeod, K. Poland, Conor Mulolland, A. Warke, Paul Conn, D. Burns, R. Smith, R. Kamath, Jonathan Webster, Ian Hodgins, Stephen Vercoe, Paul Roome, Hilary Pinnock, Jayesh Patel, Amar Ali, Nigel Hart, Richard Davies, Nigel De-Sousa, Catherine Neden, Mark Danielsen, Purnima Sharma, Sophia Galloway, Charlotte Hawkins, Raife Oliver, Martin Aylward, Mira Pattni, Gordon Irvine, Shahid Ahmad, Catherine Rothwell, Fiaz Choudhary, Sabrina Khalaque, Stephanie Short, Sharon Peters, Warwick Coulson, Neil Roberts, Amy Butler Steven Coates, Ben Ward, Daniel Jackson, Steve Walton, Diane Shepherd, Toh Wong, Mark Boon, Melanie Deacon, David Cornelius, Sarah Davies, Ben Frankel, Nick Hargreaves, Henry Choi, Jon Sumner, Tim Myhill, Salah Estifanos, Diane Geatch, Justin Wilkinson, Richard Veale, Karen Forshaw, Rob Hirst, Kashif Zaman, Catherine Liley, Rebecca Wastling, Paul McEleny, Andre Beattie, Philip Cooke, Mike Wong, Mark Pugsley, Chaminda Dooldeniya, Greg Rogers, James Bennett, Polly Jacobs, Rajesh Muvva, Matthew Adam, Robin Fox, Nicolas Thomas, Simon Cartwright, Rory Reed, Simon Randfield, Christine A’Court, Ann Flynn, Andrew Halpin, Simon Dobson, Louise Lomax, Minnal Nadaph, Iain Munro, Jane Goram, Helen Stoddart, Phil Simmons, John Shewring, Emma Bowen-Simpkins, Mark Rickenbach, Adam Blenkhorn Bhuwanendu Singh, Penny Astridge, William van Gaal, Walter Abhayaratna, Philip Thomson, Ron Lehman, Jens Kilian, David Coulshed, Andrei Catanchin, David Colquhoun, Hosen Kiat, David Eccleston, John French, Bronte Ayres, Peter Blombery, Thanh Phan, James Rogers, David O’Donnell, Sang Cheol Bae, Harry Gibbs, Patrick Carroll, Greg Starmer, Margaret Arstall, Maurits Binnekamp, Astin Lee, John Eikelboom Robert Luton, Milan Gupta, Amritanshu Shekhar Pandey, Stephen Cheung, Rolland Leader, Philippe Beaudry, Félix Ayala-Paredes, Joseph Berlingieri, John Heath, Germain Poirier, Miranda du Preez, Bradley Schweitzer, Reginald Nadeau, Ripple Dhillon, Tomasz Hruczkowski, Andrea Lavoie, Ratika Parkash, James Cha, Benoit Coutu, Paul MacDonald, Brian Ramjattan, Jorge Bonet, Saul Vizel, Paul Angaran, Sameh Fikry, Ahmed Mowafy Azza Katta, Mazen Tawfik, Moustafa Nawar, Mohamed Sobhy, Seif Kamal Abou Seif, Tarek Khairy, Ahmed Abd El-Aziz, Nasser Taha, Ashraf Reda, Atef Elbahry, Mohamed Setiha, Mohamed Gamal El Din, Magdi Elkhadem, Adel El-Etreby, David Kettles Junaid Bayat, Heidi Siebert, Adrian Horak, Ynez Kelfkens, Riaz Garda, Thayabran Pillay, Michele Guerra, Louis van Zyl, Hendrik Theron, Andrew Murray, Rikus Louw, Deon Greyling, Pindile Mntla, Siddique Ismail, Fayzal Ahmed, Johannes Engelbrecht, Shambu Maharajh, Wessel Oosthuysen, Rehana Loghdey, Veronica Ueckermann, Wael AlAl Mahmeed AbdullahNaeemi, Ghazi Yousef, Nooshin Bazargani, Munther AlOmairi, Rajan Maruthanayagam, Rupesh Singh, Ahmed Naguib, Mohamed Ibrahim, Amrish Agrawal, Mukesh Nathani, Ehab M. Esheiba, Adel Wassef, Rajeev Gupta, Michael Cox Scott Beach, Peter Duffy, Stephen Falkowski, Kevin Ferrick, Miguel Franco, W. Michael Kutayli, Annette Quick, Niraj Sharma, Vance Wilson, Stephen Miller, Mark Alberts, Edwin Blumberg, Roddy Canosa, Ted Gutowski, Rodney Ison, Jorge Garcia, Paul Mullen, Howard Noveck, Pamela Rama, Rajneesh Reddy, Marcus Williams, Daniel Nishijima, Keith Ferdinand, Ihsan Haque, Robert Mendelson, Sridevi Pitta, Daniel Theodoro, Charles Treasure, Moustafa Moustafa, Cas Cader, Walter Pharr, Alisha Oropallo, George Platt, Jaspal Gujral, James Welker, Firas Koura, Sylvia, H, John A, C, Darius, H, Jan, S, Saverio, V, Karen, P, Marianne, B, Sebastian, S, Frank, M, Gloria, K, Kakkar, A, Bassand, J, John Camm, A, Fitzmaurice, D, Fox, K, Gersh, B, Goldhaber, S, Goto, S, Haas, S, Hacke, W, Mantovani, L, Misselwitz, F, Pieper, K, Turpie, A, van Eickels, M, Verheugt, F, Gersh, K, Lucas Luciardi Harry Gibbs, H, Brodmann, M, Cools, F, Carlos Pereira Barretto, A, Connolly, S, Eikelboom, J, Corbalan, R, Jing, Z, Jansky, P, Dalsgaard Nielsen, J, Ragy, H, Raatikainen, P, Le Heuzey, J, Keltai, M, Pal Singh Sawhney, J, Agnelli, G, Ambrosio, G, Koretsune, Y, Jerjes Sánchez Díaz, C, Ten Cate, H, Atar, D, Stepinska, J, Panchenko, E, Wei Lim, T, Jacobson, B, Oh, S, Viñolas, X, Rosenqvist, M, Steffel, J, Angchaisuksiri, P, Oto, A, Parkhomenko, A, Al Mahmeed, W, Hu Kangning Chen, D, Zhao, Y, Zhang, H, Chen, J, Cao, S, Wang, D, Yang, Y, Li, W, Li, H, Yin, Y, Tao, G, Yang, P, Chen, Y, He, S, Wang, Y, Fu, G, Li, X, Wu, T, Cheng, X, Yan, X, Zhao, R, Chen, M, Xiong, L, Chen, P, Jiao, Y, Guo, Y, Xue, L, Yang, Z, Jadhavm Raghava Sarma, P, Kulkarni, G, Chandwani, P, Atulbhai Pothiwala, R, Padinhare Purayil, M, Chawla, K, Annasaheb Kothiwale, V, Raghuraman, B, Madan Vijan, V, Sawhney, J, Bantwal, G, Khan, A, Meena, R, Chopada, M, Abraham, S, Bisne, V, Vijayaraghavan, G, Roy, D, Durgaprasad, R, Ravi Shankar, A, Kumar, S, Jain, D, Bhargava, K, Kumar, V, Madappa Nagamalesh, U, Kumar Rajput, R, Koretsune Seishu Kanamori, Y, Yamamoto, K, Kumagai, K, Katsuda, Y, Yoshida, K, Toyota, F, Mizuno, Y, Misumi, I, Noguchi, H, Ando, S, Suetsugu, T, Minamoto, M, Oda, H, Adachi, S, Chiba, K, Norita, H, Tsuruta, M, Koyanagi, T, Ando, H, Higashi, T, Okada, M, Azakami, S, Komaki, S, Kumeda, K, Murayama, T, Matsumura, J, Oba, Y, Sonoda, R, Goto, K, Minoda, K, Haraguchi, Y, Suefuji, H, Miyagi, H, Kato, H, Nakamura, T, Nandate, H, Zaitsu, R, Fujiura, Y, Yoshimura, A, Numata, H, Ogawa, J, Kamogawa, Y, Murakami, K, Wakasa, Y, Yamasawa, M, Maekawa, H, Abe, S, Kihara, H, Tsunoda, S, Saito, K, Tachibana, H, Oba, I, Kuwahata, T, Higa, S, Gushiken, M, Eto, T, Chibana, H, Fujisawa, K, Shiga, Y, Sumi, H, Nagatomo, T, Atsuchi, Y, Nagoshi, T, Sanno, K, Hoshino, F, Yokota, N, Kameko, M, Tabuchi, T, Ishizawa, M, Ikeda, D, Seto, T, Iwao, T, Ishioka, N, Oshiro, K, Tsuchida, K, Hatori, Y, Takeuchi, M, Takezawa, H, Nagano, S, Iwaki, M, Nakamura, Y, Miyamoto, N, Taguchi, T, Ashida, K, Yoshizawa, N, Agata, J, Matsukawa, S, Arasaki, O, Fukuoka, S, Murakami, H, Mishima, K, Hata, Y, Sakuma, I, Obunai, K, Takamura, I, Akutsu, M, Unoki, T, Go, Y, Ikemura, M, Morii, S, Marusaki, S, Doi, H, Tanaka, M, Kusumoto, T, Kakinoki, S, Ogurusu, C, Murata, K, Shimoyama, M, Nakatsuka, M, Kitami, Y, Oyama, R, Ageta, M, Mita, T, Nagao, K, Mito, T, Minami, J, Abe, M, Fujii, M, Okawa, M, Fujito, T, Taniguchi, T, Ko, T, Kubo, H, Imamaki, M, Akiyama, M, Ueda, T, Odakura, H, Inagaki, M, Katsube, Y, Nakata, A, Tomimoto, S, Shibuya, M, Nakano, M, Ito, K, Matsuta, M, Ishiguro, M, Minagawa, T, Wada, M, Mukawa, H, Mizuguchi, M, Okuda, F, Kimura, T, Taga, K, Techigawara, M, Igarashi, M, Watanabe, H, Seo, T, Hiramitsu, S, Hosokawa, H, Hoshiai, M, Hibino, M, Miyagawa, K, Horie, H, Sugishita, N, Soma, A, Neya, K, Yoshida, T, Akahane, K, Takanaka, C, Matsui, S, Kanda, H, Kaneko, M, Nagasaka, S, Taguchi, A, Toru, S, Miyashita, A, Sasaguri, H, Nariyama, J, Hatsuno, T, Iwase, T, Sato, K, Kawai, K, Kotani, T, Tsuji, T, Sakai, H, Nishino, K, Ikeda, K, Maeda, K, Shinozuka, T, Inoue, T, Kawakami, K, Kitazumi, H, Takagi, T, Hamaoka, M, Kojima, J, Sasaki, A, Tsuchiya, Y, Betsuyaku, T, Higuchi, K, Honda, M, Hasegawa, K, Baba, T, Mineoi, K, Koeda, T, Hirasawa, K, Kumazaki, T, Nakagomi, A, Otaki, E, Shindo, T, Hirayama, H, Sugimoto, C, Yamagishi, T, Mizuguchi, I, Sezaki, K, Niwa, I, Takenaka, K, Iiji, O, Taya, K, Kitazawa, H, Ueda, S, Kakuda, H, Ono, T, Oriso, S, Kamata, J, Nanke, T, Maeda, I, Matsuura, Y, Teragawa, H, Maruyama, Y, Takei, K, Kito, T, Asano, H, Matsushita, K, Nakamura, M, Washizuka, T, Sawano, M, Arima, S, Arai, H, Shinohara, H, Takai, H, Furukawa, N, Ota, A, Aoki, K, Yamamoto, T, Kasai, T, Suzuki, S, Shibata, N, Watanabe, M, Nishihata, Y, Arino, T, Okuyama, M, Wakiyama, T, Kato, T, Sasagawa, Y, Tana, T, Hayashi, Y, Hirota, S, Abe, Y, Saito, Y, Uchiyama, H, Takeda, H, Ono, H, Tohyo, S, Hanazono, N, Miyajima, S, Shimono, H, Aoyama, T, Shozawa, Y, Niijima, Y, Murai, O, Inaba, H, Nomura, K, Nozoe, M, Suzuki, K, Furukawa, T, Shiraiwa, T, Ito, N, Nagai, S, Nakahara, S, Shimoyama, Y, Ohara, N, Kozuka, T, Okita, H, Endo, M, Goto, T, Hirose, M, Nagata, E, Nakanishi, N, Mori, T, Seki, S, Okamoto, K, Moriai, O, Emura, Y, Fukuda, T, Date, H, Kawakami, S, Ueyama, Y, Fudo, T, Imaizumi, M, Ogawa, T, Take, S, Ikeda, H, Nishioka, H, Sakamoto, N, Ikeoka, K, Wakaki, N, Doiuchi, J, Kira, T, Tada, M, Tsuzaki, K, Miura, N, Fujisawa, Y, Furumoto, W, Fujisawa, A, Nakamura, R, Komatsu, H, Fujiki, R, Kawano, S, Nishizawa, K, Kato, Y, Azuma, J, Yasui, K, Amano, T, Sekine, Y, Honzawa, T, Koshibu, Y, Sakamoto, Y, Seta, Y, Miyaguchi, S, Morishita, K, Samejima, Y, Sasaki, T, Iseki, F, Kobayashi, T, Kano, H, Kim, J, Yamaguchi, H, Takagi, Y, Onuki Pearce, Y, Suzuki, Y, Fukui, T, Nakayama, T, Kanai, H, Kawano, Y, Ino, T, Miyoshi, H, Miyamoto, Y, Shigekiyo, M, Ono, S, Okamoto, Y, Ubukata, S, Kodera, K, Oriuchi, T, Matsumoto, N, Inagaki, K, Iseki, A, Goda, T, Katsuki, T, Sato, A, Mori, E, Tsubokura, T, Shudo, H, Fujimoto, S, Katsuya, T, Furukawa, Y, Narumi, J, Owari, M, Inakura, T, Anno, T, Shirakawa, K, Keong Ching Toon Wei Lim, C, Foo, D, Wong, K, Yuyang, T, Oh Hui Nam Park, S, Kim, W, Lee, H, Jang, S, Hyeok Kim, D, Ryu, D, Shim, J, Kim, D, Ju Choi, D, Seog Oh, Y, Cho, M, Kim, H, Jeon, H, Shin, D, Weon Park, S, Ki Park, H, Han, S, Hoon Sung, J, Park, H, Nam, G, Keun On, Y, Euy Lim, H, Kwak, J, Cha, T, Jong Hong, T, Hoon Park, S, Han Yoon, J, Kim, N, Kim, K, Chun Jung, B, Hwang, G, Kim, C, Rungaramsin Peerapat Katekangplu, S, Khunrong, P, Bunyapipat, T, Wongcharoen, W, Kaewsuwanna, P, Siriwattana, K, Tiyanon, W, Pattanaprichakul, S, Likittanasombat, K, Cholsaringkarl, D, Boonyapisit, W, Cheewatanakornkul, S, Silaruks, S, Hutayanon, P, Chawanadelert, S, Chattranukulchai, P, Chatlaong, B, Santanakorn, Y, Kanokphatcharakun, K, Mongkolwongroj, P, Jai-Aue, S, Komson, O, Altun Ali Aydinlar, A, Topsakal, R, Ongen, Z, Acikel, S, Yildiray Sahin, D, Yilmaz, O, Birhan Yilmaz, M, Pekdemir, H, Demir, M, Sucu, M, Sahiner, L, Ersanli, M, Okuyan, E, Aras, D, Rolandi Adrian Cesar Ingaramo, F, Alberto Sambadaro, G, Fernandez Caputi, V, Luciardi, H, Graciela Berman, S, Dragotto, P, Javier Kleiban, A, Centurion, N, Andres Ahuad Guerrero, R, Adalberto Di Paola, L, Dario Dran, R, Egido, J, Jose Fosco, M, Alfredo Sinisi, V, Rodolfo Cartasegna, L, Gomez Vilamajo, O, Luis Ramos, J, Sassone, S, Zapata, G, Conde, D, Giacomi, G, Alfredo Fernandez, A, Alberto Berli, M, Ferroni, F, Celestino Sobral Filho Jefferson Jaber, D, Vidal Armaganijan, L, Roberto Frack Costantini, C, Steffens, A, Kunz Sebba Barroso de Souzaem, W, David de Souza Neto, J, Márcio Ribeiro, J, Silveira Teixeira, M, Rossi, P, Pires, L, Moreira, D, Carlos Moura Jorge, J, Menezes Lorga Filho, A, Bodanese, L, Westerlund Montera, M, Henrique Del Carlo, C, Abdalla Saad, J, Augusto Alves da Costa, F, Lopes, R, Roberto de Araújo, G, Roberto Manenti, E, Francisco Kerr Saraiva, J, Carlos Ferreira Braga, J, Negri, A, Moncada, C, Precoma, D, Roquette, F, Reis, G, Álvaro Ramos Filho, R, Lanna Figueiredo, E, Vieira Botelho, R, Munhoz da Fontoura Tavares, C, Carlos Finimundi, H, Kochi, A, Cássio Broilo França, C, Alban, F, Bernardo Aranha Rosito, G, Batista de Moura Xavier Moraes Junior, J, Tadeu Tumelero, R, Maia, L, Simões de Almeida, R, Carter do Carmo Borges, N, Gustavo Gomes Ferreira, L, Corbalán Benjamin Aleck Joseh Stockins Fernandez, R, Montecinos, H, Lanas, F, Larico Gómez, M, Astudillo, C, Conejeros, C, Marin Cuevas, P, Forero, A, Bugueño Gutiérrez, C, Aguilar, J, Potthoff Cardenas, S, Eggers, G, Houzvic, C, Rey, C, Arriagada, G, Charme Vilches, G, Jerjes Sanchez Diaz Jesus Jaime Illescas Diaz, C, Leal Cantu, R, Guadalupe Ramos Zavala, M, Cabrera Jardines, R, Espinola Zavaleta, N, Lopez Rosas, E, Antonio Llamas Esperón, G, Pozas, G, Cardona Muñoz, E, Matadamas Hernandez, N, Leyva Rendon, A, Garcia Hernandez, N, de los Rios Ibarra, M, Ramon Virgen Carrillo, L, Lopez Villezca, D, Hernandez Herrera, C, Jose Lopez Prieto, J, Gaona Rodriguez, R, Villeda Espinosa, E, Flores Martinez, D, Velasco Barcena, J, Fierro Fierro, O, Rodriguez Briones, I, Luis Leiva Pons, J, Alvarez Lopez, H, Olvera Ruiz, R, Gerardo Cantu Brito, C, Julian Jose Roberto Chuquiure Valenzuela, E, Reyes Sanchez, R, Esteban Bazzoni Ruiz, A, Martin Lopez Ruiz, O, Arriaga Nava, R, David Morales Cerda, J, Fajardo Campos, P, Benavides Gonzalez, M, Brodmann Kurt Lenz, M, Hagn, C, Foechterle, J, Drexel, H, Huber, K, Podczeck-Schweighofer, A, Winkler, M, Schneeweiss, B, Gegenhuber, A, Lang, W, Eichinger-Hasenauer, S, Kaserer, P, Sykora, J, Rasch, H, Strohmer, B, Capiau Geert Vervoort, L, Wollaert, B, Hollanders, G, Vercammen, J, Faes, D, Balthazar, Y, Delforge, M, Xhaet, O, Striekwold, H, Thoeng, J, Hermans, K, Mairesse, G, Anné, W, Blankoff, I, Beutels, M, Verstraete, S, Vandergoten, P, Purnode, P, Godart, P, Boussy, T, Desfontaines, P, Heyse, A, Voet, J, De Wolf, A, Zidkova Petr Jansky, E, Spacek, R, Machova, V, Ludka, O, Olsr, J, Kotik, L, Racz, B, Ferkl, R, Hubac, J, Kotik, I, Monhart, Z, Burianova, H, Jerabek, O, Pisova, J, Petrova, I, Dedek, V, Honkova, M, Podrazil, P, Reichert, P, Spinar, J, Novak, M, Durdil, V, Plocova, K, Lastuvka, J, Nielsen Steen Husted, J, Dominguez, H, Hintze, U, Rasmussen, S, Sygehus, N, Bremmelgaard, A, Markenvard, J, Børger, J, Solgaard, J, Eriksen, E, Løkkegaard, T, Bruun, M, Mertz, J, Schou, M, Olsen, M, Raatikainen Carmela Viitanen, P, Paganelli Joël Ohayon, F, Casassus, F, Galinier, M, Gottwalles, Y, Loiselet, P, Muller, J, Bassel Koujan, M, Marquand, A, Destrac, S, Piot, O, Delarche, N, Cebron, J, Guenoun, M, Guedj-Meynier, D, Lokesh, A, Zuber, M, Amarenco, P, Ellie, E, Kadouch, J, Fournier, P, Huberman, J, Lemaire, N, Rodier, G, Vandamme, X, Sibon, I, Neau, J, Hélène Mahagne, M, Mielot, A, Bonnefoy, M, Churet, J, Navarre, V, Sellem, F, Monniot, G, Boyes, J, Doucet, B, Martelet, M, Obadia, D, Crousillat, B, Mouallem, J, Bearez, E, Philippe Brugnaux, J, Fedorowsky, A, Nazeyrollas, P, Berneau, J, Chemin, F, Schellong Harald Darius, S, Koeniger, G, Kopf, A, Gerbaulet, U, Kellner, B, Schaefer, T, Purr, J, Eißfeller, E, Zauzig, H, Riegel, P, Axthelm, C, Heinz, G, Menke, H, Pustelnik, A, Zutz, S, Eder, W, Rehling, G, Glatzel, D, Ludwig, N, Sandow, P, Wiswedel, H, Wildenauer, C, Schoen, S, Schwarz, T, Babyesiza, A, Kropp, M, Zimny, H, Kahl, F, Caspar, A, Omankowsky, S, Laessig, T, Hartmann, H, Lehmann, G, Bindig, H, Hergdt, G, Reimer, D, Hauk, J, Michel, H, Werner Erdle, P, Dorsch, W, Dshabrailov, J, Rapp, K, Vormann, R, Mueller, T, Mayer, P, Horstmeier, U, Eissing, V, Hey, H, Leuchtgens, H, Lilienweiss, V, Mueller, H, Schubert, C, Lauer, H, Buchner, T, Brauer, G, Kamin, S, Mueller, K, Baumbach, S, Abdel-Qader, M, Ebert, H, Schwencke, C, Bernhardt, P, Karolyi, L, Sievers, B, Haverkamp, W, Roehnisch, J, Vertes Gabor Szantai, A, Matoltsy, A, Kanakaridisz, N, Boda, Z, Kis, E, Gaszner, B, Juhasz, F, Juhasz, G, Kancz, S, Laszlo, Z, May, Z, Merkely, B, Noori, E, Habon, T, Polgar, P, Szalai, G, Vangel, S, Nagy, A, Engelthaler, G, Ferenczi, J, Egyutt, M, Martini Leone Maria Cristina, G, Tiraferri, E, Santoro, R, Testa, S, Di Minno, G, Moia, M, Maria Caimi, T, Tessitori, M, Cappelli, R, Poli, D, Quintavalla, R, Cosmi, F, Fanelli, R, Oriana, V, Reggio, R, Santi, R, Pancaldi, L, De Cristofaro, R, Guazzaloca, G, De Blasio, A, Salerno Uriate, J, Lillo, F, Maria Pogliani, E, Bilo, G, Accogli, M, Mariani, A, Feola, M, Raisaro, A, Fattore, L, Mauric, A, Germini, F, Tedeschi, L, Settimi, M, Nicoli, S, Ricciarini, P, Argena, A, Ronchini, P, Bulla, C, Tradati, F, Volpe, M, D’Avino, M, Grazia Bongiorni, M, Severi, S, Capucci, A, Lodigiani, C, Salomone, E, Serviddio, G, Tondo, C, Golino, P, Mazzone, C, Iacopino, S, Ruiter, H, Lucassen, A, Adriaansen, H, Bongaerts, M, Pieterse, M, van Guldener, C, Herrman, J, Nierop, S, Hoogslag, P, Hermans, W, Groenemeijer, B, Terpstra, W, Buiks, C, Boersma, L, Berge Per Anton Sirnes, E, Gjertsen, E, Hole, T, Erga, K, Hallaråker, A, Skjelvan, G, Østrem, A, Ghezai, B, Svilaas, A, Christersson, P, Øien, T, Høegh Henrichsen, S, Erik Otterstad, J, Berg-Johansen, J, Stepinska Andrzej Gieroba, J, Biedrzycka, M, Ogorek, M, Wozakowska-Kaplon, B, Loboz-Grudzien, K, Jaroslaw, Supinski, W, Kuzniar, J, Zaluska, R, Hiczkiewicz, J, Swiatkowska-Byczynska, L, Kucharski, L, Gruchala, M, Minc, P, Olszewski, M, Kania, G, Krzciuk, M, Lajkowski, Z, Ostrowska-Pomian, B, Lewczuk, J, Zinka, E, Karczmarczyk, A, Chmielnicka-Pruszczynska, M, Wozniak-Skowerska, I, Opolski, G, Bronisz, M, Glanowska, G, Ruszkowski, P, Skonieczny, G, Sciborski, R, Okopien, B, Kukla, P, Galbas, K, Cymerman, K, Jurowiecki, J, Miekus, P, Myszka, W, Mazur, S, Lysek, R, Baszak, J, Rusicka-Piekarz, T, Raczak, G, Domanska, E, Nessler, J, Lesnik, J, Eltishcheva Roman Libis, V, Kamalov, G, Belenky, D, Egorova, L, Khokhlov, A, Yakupov, E, Zateyshchikov, D, Barbarash, O, Miller, O, Mazur, E, Zrazhevskiy, K, Novikova, T, Moiseeva, Y, Polkanova, E, Sobolev, K, Rossovskaya, M, Shapovalova, Y, Kolesnikova, A, Nikolaev, K, Zemlianskaia, O, Zateyshchikova, A, Kostenko, V, Popov, S, Poltavskaya, M, Edin, A, Aleksandrova Oksana Drapkina, E, Vishnevsky, A, Nagibovich, O, Chizhov, P, Rachkova, S, Sergeev, M, Kurylo, B, Ushakov, A, Vinolas Pere Alvarez Garcia, X, Fernanda Lopez Fernandez, M, Tercedor Sanchez, L, Tranche Iparraguirre, S, Toran Monserrat, P, Marquez Contreras, E, Isart Rafecas, J, Motero Carrasco, J, Garcia Pavia, P, Gomez Pajuelo, C, Miguel Rincon Diaz, L, Fernando Iglesias Alonso, L, Grande Ruiz, A, Merce Klein, J, Ramon Gonzalez Juanatey, J, Monte Collado, I, Palacin Piquero, H, Brotons Cuixart, C, Fernandez Escobar, E, i Llibre, J, Corros Vicente, C, Vida Gutierrez, M, Epelde Gonzalo, F, Alexandre Almeida Fernandez, C, Martinez Navarro, E, Jose Montero Alia, J, Barreda Gonzalez, M, Angels Moleiro Oliva, M, Iglesias Sanmartin, J, Jimenez Gonzalez, M, del Mar Rodriguez Alvarez, M, Herreros Melenchon, J, Ripoll Vera, T, Jimenez Navarro, M, Vazquez Caamano, M, Fe Arcocha Torres, M, Marcos Gomez, G, Iniguez Romo, A, Angel Prieto Diaz, M, Rosenqvist Alexander Wirdby, M, Centrumkliniken, Lindén, J, Henriksson, K, Elmersson, M, Egilsson, A, Börjesson, U, Svärd, G, Liu, B, Lindh, A, Olsson, L, Gustavsson, M, Andersson, L, Benson, L, Bothin, C, Hajimirsadeghi, A, Martinsson, B, Ericsson, M, Ohlsson, Å, Lindvall, H, Svensson, P, Thörne, K, Händel, H, Platonov, P, Bernsten, F, Timberg, I, Crisby, M, Karlsson, J, Andersson, A, Malmqvist, L, Engdahl, J, Thulin, J, Hot-Bjelak, A, Jensen, S, Stalby, P, Steffel Johann Debrunner, J, Beer, J, Shah, D, Rudyk Vira Tseluyko, I, Karpenko, O, Zhurba, S, Kraiz, I, Parkhomenko, O, Kupnovytska, I, Seredyuk, N, Mostovoy, Y, Ushakov, O, Koval, O, Kovalskiy, I, Svyshchenko, Y, Sychov, O, Stanislavchuk, M, Yagensky, A, Tykhonova, S, Fushtey, I, Murdoch Naresh Chauhan, W, Goodwin, D, Lumley, L, Patel, R, Saunders, P, Wong, B, Cameron, A, Patel, N, Jhittay, P, Ross, A, Kainth, M, Ladha, K, Douglas, K, Pickavance, G, Mcdonnell, J, Handscombe, L, Gooding, T, Wagner, H, Cumberlidge, Bradshaw, C, Bromham, C, Jones, K, Suryani, S, Coates, R, Sarai, B, Willcock, W, Sircar, S, Cairns, J, Gilliand, A, Bilas, R, Strieder, E, Hutchinson, P, Wakeman, A, Stokes, M, Kirby, G, Vishwanathan, B, Bird, N, Evans, P, Clark, M, Bisatt, J, Litchfield, J, Fisher, E, Fooks, T, Kelsall, R, Paul, N, Alborough, E, Aziz, M, Ramesh, C, Wilson, P, Franklin, S, Fairhead, S, Thompson, J, Chowan, H, Taylor, G, Tragen, D, Parfitt, M, Seamark, C, Paul, C, Richardson, M, Jefferies, A, Sharp, H, Jones, H, Giles, C, Bramley, M, Williams, P, Aldegather, J, Wetherell, S, Lumb, W, Scouller, F, Macey, N, Rogers, S, Stipp, Y, West, R, Pinney, P, Wadeson, P, Matthews, J, Pandya, P, Gallagher, A, Railton, T, Davies, E, Mcclure, J, Jacobs, M, Hutton, C, Thompson, R, Sinha, B, Butter, K, Barrow, S, Little, H, Russell, D, Choudhary, U, Haq, I, Ainsworth, P, Jones, C, Weeks, P, Eden, J, Gibbons, L, Glencross, J, Macleod, A, Poland, K, Mulolland, C, Warke, A, Conn, P, Burns, D, Smith, R, Kamath, R, Webster, J, Hodgins, I, Vercoe, S, Roome, P, Pinnock, H, Patel, J, Ali, A, Hart, N, Davies, R, De-Sousa, N, Neden, C, Danielsen, M, Sharma, P, Galloway, S, Hawkins, C, Oliver, R, Aylward, M, Pattni, M, Irvine, G, Ahmad, S, Rothwell, C, Choudhary, F, Khalaque, S, Short, S, Peters, S, Coulson, W, Roberts, N, Butler Steven Coates, A, Ward, B, Jackson, D, Walton, S, Shepherd, D, Wong, T, Boon, M, Deacon, M, Cornelius, D, Davies, S, Frankel, B, Hargreaves, N, Choi, H, Sumner, J, Myhill, T, Estifanos, S, Geatch, D, Wilkinson, J, Veale, R, Forshaw, K, Hirst, R, Zaman, K, Liley, C, Wastling, R, Mceleny, P, Beattie, A, Cooke, P, Wong, M, Pugsley, M, Dooldeniya, C, Rogers, G, Bennett, J, Jacobs, P, Muvva, R, Adam, M, Fox, R, Thomas, N, Cartwright, S, Reed, R, Randfield, S, A’Court, C, Flynn, A, Halpin, A, Dobson, S, Lomax, L, Nadaph, M, Munro, I, Goram, J, Stoddart, H, Simmons, P, Shewring, J, Bowen-Simpkins, E, Rickenbach, M, Blenkhorn Bhuwanendu Singh, A, Astridge, P, van Gaal, W, Abhayaratna, W, Thomson, P, Lehman, R, Kilian, J, Coulshed, D, Catanchin, A, Colquhoun, D, Kiat, H, Eccleston, D, French, J, Ayres, B, Blombery, P, Phan, T, Rogers, J, O’Donnell, D, Cheol Bae, S, Gibbs, H, Carroll, P, Starmer, G, Arstall, M, Binnekamp, M, Lee, A, Eikelboom Robert Luton, J, Gupta, M, Shekhar Pandey, A, Cheung, S, Leader, R, Beaudry, P, Ayala-Paredes, F, Berlingieri, J, Heath, J, Poirier, G, du Preez, M, Schweitzer, B, Nadeau, R, Dhillon, R, Hruczkowski, T, Lavoie, A, Parkash, R, Cha, J, Coutu, B, Macdonald, P, Ramjattan, B, Bonet, J, Vizel, S, Angaran, P, Fikry, S, Mowafy Azza Katta, A, Tawfik, M, Nawar, M, Sobhy, M, Kamal Abou Seif, S, Khairy, T, Abd El-Aziz, A, Taha, N, Reda, A, Elbahry, A, Setiha, M, Gamal El Din, M, Elkhadem, M, El-Etreby, A, Kettles Junaid Bayat, D, Siebert, H, Horak, A, Kelfkens, Y, Garda, R, Pillay, T, Guerra, M, van Zyl, L, Theron, H, Murray, A, Louw, R, Greyling, D, Mntla, P, Ismail, S, Ahmed, F, Engelbrecht, J, Maharajh, S, Oosthuysen, W, Loghdey, R, Ueckermann, V, AlAl Mahmeed AbdullahNaeemi, W, Yousef, G, Bazargani, N, Alomairi, M, Maruthanayagam, R, Singh, R, Naguib, A, Ibrahim, M, Agrawal, A, Nathani, M, Esheiba, E, Wassef, A, Gupta, R, Cox Scott Beach, M, Duffy, P, Falkowski, S, Ferrick, K, Franco, M, Michael Kutayli, W, Quick, A, Sharma, N, Wilson, V, Miller, S, Alberts, M, Blumberg, E, Canosa, R, Gutowski, T, Ison, R, Garcia, J, Mullen, P, Noveck, H, Rama, P, Reddy, R, Williams, M, Nishijima, D, Ferdinand, K, Haque, I, Mendelson, R, Pitta, S, Theodoro, D, Treasure, C, Moustafa, M, Cader, C, Pharr, W, Oropallo, A, Platt, G, Gujral, J, Welker, J, Koura, F, Haas, Sylvia, Camm, John A, Harald, Darius, Steffel, Jan, Virdone, Saverio, Pieper, Karen, Brodmann, Marianne, Schellong, Sebastian, Misselwitz, Frank, Kayani, Gloria, Ajay K. Kakkar, Jean-Pierre Bassand, A. John Camm, David A. Fitzmaurice, Keith A. A. Fox, Bernard J. Gersh, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Karen S. Pieper, Alexander G. G. Turpie, Martin van Eickels, Freek W. A. Verheugt, Keith A. A. Fox Bernard J. Gersh, Hector Lucas Luciardi Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, John Eikelboom, Ramon Corbalan, Zhi-Cheng Jing, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, Dayi Hu Kangning Chen, Yusheng Zhao, Huaiqin Zhang, Jiyan Chen, Shiping Cao, Daowen Wang, Yuejin Yang, Weihua Li, Hui Li, Yuehui Yin, Guizhou Tao, Ping Yang, Yingmin Chen, Shenghu He, Yong Wang, Guosheng Fu, Xin Li, Tongguo Wu, Xiaoshu Cheng, Xiaowei Yan, Ruiping Zhao, Moshui Chen, Longgen Xiong, Ping Chen, Yang Jiao, Ying Guo, Li Xue, Zhiming Yang, Praveen Jadhavm Raghava Sarma, Govind Kulkarni, Prakash Chandwani, Rasesh Atulbhai Pothiwala, Mohanan Padinhare Purayil, Kamaldeep Chawla, Veerappa Annasaheb Kothiwale, Bagirath Raghuraman, Vinod Madan Vijan, Jitendra Sawhney, Ganapathi Bantwal, Aziz Khan, Ramdhan Meena, Manojkumar Chopada, Sunitha Abraham, Vikas Bisne, Govindan Vijayaraghavan, Debabrata Roy, Rajashekhar Durgaprasad, A. G. Ravi Shankar, Sunil Kumar, Dinesh Jain, Kartikeya Bhargava, Vinay Kumar, Udigala Madappa Nagamalesh, Rajeeve Kumar Rajput, Yukihiro Koretsune Seishu Kanamori, Kenichi Yamamoto, Koichiro Kumagai, Yosuke Katsuda, Keiki Yoshida, Fumitoshi Toyota, Yuji Mizuno, Ikuo Misumi, Hiroo Noguchi, Shinichi Ando, Tetsuro Suetsugu, Masahiro Minamoto, Hiroyuki Oda, Susumu Adachi, Kei Chiba, Hiroaki Norita, Makoto Tsuruta, Takeshi Koyanagi, Kunihiko Yamamoto, Hiroshi Ando, Takayuki Higashi, Megumi Okada, Shiro Azakami, Shinichiro Komaki, Kenshi Kumeda, Takashi Murayama, Jun Matsumura, Yurika Oba, Ryuji Sonoda, Kazuo Goto, Kotaro Minoda, Yoshikuni Haraguchi, Hisakazu Suefuji, Hiroo Miyagi, Hitoshi Kato, Tsugihiro Nakamura, Tadashi Nakamura, Hidekazu Nandate, Ryuji Zaitsu, Yoshihisa Fujiura, Akira Yoshimura, Hiroyuki Numata, Jun Ogawa, Yasuyuki Kamogawa, Kinshiro Murakami, Yutaka Wakasa, Masanori Yamasawa, Hiromitsu Maekawa, Sumihisa Abe, Hajime Kihara, Satoru Tsunoda, Katsumi Saito, Hiroki Tachibana, Ichiro Oba, Takashi Kuwahata, Satoshi Higa, Masamichi Gushiken, Takuma Eto, Hidetoshi Chibana, Kazuaki Fujisawa, Yuhei Shiga, Hirokuni Sumi, Toshihisa Nagatomo, Yoshihiko Atsuchi, Toshiro Nagoshi, Kazuhisa Sanno, Fumihiro Hoshino, Naoto Yokota, Masahiro Kameko, Toshifumi Tabuchi, Munesumi Ishizawa, Yoshitake Fujiura, Daisuke Ikeda, Taku Seto, Tetsu Iwao, Norio Ishioka, Koichi Oshiro, Keizo Tsuchida, Yutaka Hatori, Motoshi Takeuchi, Hiroto Takezawa, Shinjiro Nagano, Masaaki Iwaki, Yuichiro Nakamura, Naomasa Miyamoto, Toshifumi Taguchi, Ko Ashida, Naoto Yoshizawa, Jun Agata, Seishiro Matsukawa, Osamu Arasaki, Shuji Fukuoka, Hirofumi Murakami, Kazuya Mishima, Yoshiki Hata, Ichiro Sakuma, Kotaro Obunai, Ichiro Takamura, Mitsuyuki Akutsu, Toshihide Unoki, Yoshinori Go, Makoto Ikemura, Shoji Morii, Shigeru Marusaki, Hideo Doi, Mitsuru Tanaka, Takaaki Kusumoto, Shigeo Kakinoki, Chiga Ogurusu, Kazuya Murata, Masaki Shimoyama, Masami Nakatsuka, Yutaka Kitami, Yoichi Nakamura, Hiroshi Oda, Rikimaru Oyama, Masato Ageta, Teruaki Mita, Kazuhiko Nagao, Takafumi Mito, Junichi Minami, Mitsunori Abe, Masako Fujii, Makoto Okawa, Tsuneo Fujito, Toshiya Taniguchi, Tenei Ko, Hiroshi Kubo, Mizuho Imamaki, Masahiro Akiyama, Takashi Ueda, Hironori Odakura, Masahiko Inagaki, Yoshiki Katsube, Atsuyuki Nakata, Shinobu Tomimoto, Mitsuhiro Shibuya, Masayuki Nakano, Kenichiro Ito, Masahiro Matsuta, Motoyuki Ishiguro, Taro Minagawa, Masamichi Wada, Hiroaki Mukawa, Masato Mizuguchi, Fumio Okuda, Teruaki Kimura, Kuniaki Taga, Masaaki Techigawara, Morio Igarashi, Hiroshi Watanabe, Toshihiko Seo, Shinya Hiramitsu, Hiroaki Hosokawa, Mitsumoto Hoshiai, Michitaka Hibino, Koichi Miyagawa, Hideki Horie, Nobuyoshi Sugishita, Yukio Shiga, Akira Soma, Kazuo Neya, Tetsuro Yoshida, Kunio Akahane, Sen Adachi, Chiei Takanaka, Saori Matsui, Hirofumi Kanda, Masanori Kaneko, Shiro Nagasaka, Atsushi Taguchi, Shuta Toru, Kazuyuki Saito, Akiko Miyashita, Hiroki Sasaguri, Jin Nariyama, Taketo Hatsuno, Takash Iwase, Kazuki Sato, Kazuya Kawai, Tomobumi Kotani, Tsuyoshi Tsuji, Hirosumi Sakai, Kiyoshi Nishino, Kenichi Ikeda, Kazuo Maeda, Tomohiro Shinozuka, Takeshi Inoue, Koichi Kawakami, Hiromichi Kitazumi, Tsutomu Takagi, Mamoru Hamaoka, Jisho Kojima, Akitoshi Sasaki, Yoshihiro Tsuchiya, Tetsuo Betsuyaku, Koji Higuchi, Masaaki Honda, Koichi Hasegawa, Takao Baba, Kazuaki Mineoi, Toshihiko Koeda, Kunihiko Hirasawa, Toshihide Kumazaki, Akira Nakagomi, Eiji Otaki, Takashi Shindo, Hiroyoshi Hirayama, Chikako Sugimoto, Takashi Yamagishi, Ichiro Mizuguchi, Kazunori Sezaki, Isamu Niwa, Ken Takenaka, Osamu Iiji, Koichi Taya, Hitoshi Kitazawa, samu Ueda, Hirokazu Kakuda, Takuya Ono, Seizo Oriso, Junya Kamata, Toshihiko Nanke, Itaru Maeda, Yoshifusa Matsuura, Hiroki Teragawa, Yasuyuki Maruyama, Kazuo Takei, Hajime Horie, Tetsutaro Kito, Hiroshi Asano, Koji Matsushita, Masaichi Nakamura, Takashi Washizuka, Tomoki Yoshida, Masato Sawano, Shinichi Arima, Hidekazu Arai, Hisanori Shinohara, Hiroyuki Takai, Nobufusa Furukawa, Akira Ota, Kentaro Yamamoto, Kenji Aoki, Taku Yamamoto, Takeaki Kasai, Shunji Suzuki, Shu Suzuki, Nitaro Shibata, Masayuki Watanabe, Yosuke Nishihata, Toru Arino, Masaki Okuyama, Tetsushi Wakiyama, Tomoko Kato, Yasuo Sasagawa, Takeshi Tana, Yoshihito Hayashi, Shinichi Hirota, Yukihiko Abe, Yoshihiro Saito, Hirohide Uchiyama, Hiroshi Takeda, Hiroshi Ono, Shuichi Tohyo, Naoto Hanazono, Seiichi Miyajima, Hisashi Shimono, Takuma Aoyama, Yasunobu Shozawa, Yawara Niijima, Osamu Murai, Hideko Inaba, Katsumasa Nomura, Masatsugu Nozoe, Kazuo Suzuki, Toshiyuki Furukawa, Toshihiko Shiraiwa, Nobuhisa Ito, Shunichi Nagai, Kiyoharu Sato, Shiro Nakahara, Yujin Shimoyama, Naoko Ohara, Teruhiko Kozuka, Hideaki Okita, Masato Endo, Tsutomu Goto, Makoto Hirose, Emiko Nagata, Noriyuki Nakanishi, Toshizumi Mori, Shuichi Seki, Katsuhiro Okamoto, Osamu Moriai, Yoko Emura, Tsuyoshi Fukuda, Haruhiko Date, Shuichi Kawakami, Sho Nagai, Yuya Ueyama, Tetsuro Fudo, Mitsuru Imaizumi, Takuo Ogawa, Shunsuke Take, Hideo Ikeda, Hiroaki Nishioka, Norihiko Sakamoto, Kiyomitsu Ikeoka, Nobuo Wakaki, Masatake Abe, Junji Doiuchi, Tetsuya Kira, Masato Tada, Ken Tsuzaki, Naoya Miura, Yasuaki Fujisawa, Wataru Furumoto, Susumu Suzuki, Akinori Fujisawa, Ryosai Nakamura, Hiroyasu Komatsu, Rei Fujiki, Shuichi Kawano, Keijiro Nishizawa, Yoji Kato, Junya Azuma, Kiyoshi Yasui, Toshio Amano, Yasuhiro Sekine, Tatsuo Honzawa, Yuichiro Koshibu, Yasuhide Sakamoto, Yukihiro Seta, Shingo Miyaguchi, Kojuro Morishita, Yasuko Samejima, Toyoshi Sasaki, Fumiko Iseki, Toshiyuki Kobayashi, Hiroshi Kano, Jaeyoung Kim, Hiroshi Yamaguchi, Yoichi Takagi, Yoko Onuki Pearce, Yasuyuki Suzuki, Takayuki Fukui, Toru Nakayama, Hideaki Kanai, Yoshiyuki Kawano, Tetsuji Ino, Hironori Miyoshi, Yasufumi Miyamoto, Masahito Shigekiyo, Shimato Ono, Yutaka Okamoto, Satoshi Ubukata, Kojiro Kodera, Tatsuo Oriuchi, Naoki Matsumoto, Koichi Inagaki, Atsushi Iseki, Tomohiro Yoshida, Toshihiro Goda, Tsukasa Katsuki, Atsushi Sato, Etsuo Mori, Toshio Tsubokura, Hiroshi Shudo, Shunichi Fujimoto, Tomohiro Katsuya, Yoshiyuki Furukawa, Hiroshi Hosokawa, Jun Narumi, Kiichiro Yamamoto, Masaki Owari, Takuya Inakura, Takafumi Anno, Kazuyuki Shirakawa, Chi Keong Ching Toon Wei Lim, David Foo, Kelvin Wong, Tan Yuyang, Seil Oh Hui Nam Park, Woo-Shik Kim, HyeYoung Lee, Sung-Won Jang, Dae Hyeok Kim, Jun Kim, DongRyeol Ryu, Jaemin Shim, Dae-Kyeong Kim, Dong Ju Choi, Yong Seog Oh, Myeong-Chan Cho, Hack-Lyoung Kim, Hui-Kyung Jeon, Dong-Gu Shin, Sang Weon Park, Hoon Ki Park, Sang-Jin Han, Jung Hoon Sung, Hyung-Wook Park, Gi-Byoung Nam, Young Keun On, Hong Euy Lim, JaeJin Kwak, Tae-Joon Cha, Taek Jong Hong, Seong Hoon Park, Jung Han Yoon, Nam-Ho Kim, Kee-Sik Kim, Byung Chun Jung, Gyo-Seung Hwang, Chong-Jin Kim, Sakda Rungaramsin Peerapat Katekangplu, Porames Khunrong, Thanita Bunyapipat, Wanwarang Wongcharoen, Pinij Kaewsuwanna, Khanchai Siriwattana, Waraporn Tiyanon, Supalerk Pattanaprichakul, Khanchit Likittanasombat, Doungrat Cholsaringkarl, Warangkana Boonyapisit, Sirichai Cheewatanakornkul, Songkwan Silaruks, Pisit Hutayanon, Seksan Chawanadelert, Pairoj Chattranukulchai, Boonsert Chatlaong, Yingsak Santanakorn, Khompiya Kanokphatcharakun, Piya Mongkolwongroj, Sasivimon Jai-Aue, Ongkarn Komson, Armagan Altun Ali Aydinlar, Ramazan Topsakal, Zeki Ongen, Sadik Acikel, Durmus Yildiray Sahin, Ozcan Yilmaz, Mehmet Birhan Yilmaz, Hasan Pekdemir, Mesut Demir, Murat Sucu, Levent Sahiner, Murat Ersanli, Ertugrul Okuyan, Dursun Aras, Florencia Rolandi Adrian Cesar Ingaramo, Gustavo Alberto Sambadaro, Vanina Fernandez Caputi, Hector Luciardi, Sofia Graciela Berman, Pablo Dragotto, Andres Javier Kleiban, Nestor Centurion, Rodolfo Andres Ahuad Guerrero, Leonel Adalberto Di Paola, Ricardo Dario Dran, Javier Egido, Matias Jose Fosco, Victor Alfredo Sinisi, Luis Rodolfo Cartasegna, Oscar Gomez Vilamajo, Jose Luis Ramos, Sonia Sassone, Gerardo Zapata, Diego Conde, Guillermo Giacomi, Alberto Alfredo Fernandez, Mario Alberto Berli, Fabian Ferroni, Dário Celestino Sobral Filho Jefferson Jaber, Luciana Vidal Armaganijan, Costantino Roberto Frack Costantini, André Steffens, Weimar Kunz Sebba Barroso de Souzaem, João David de Souza Neto, José Márcio Ribeiro, Marcelo Silveira Teixeira, Paulo Rossi, Leonardo Pires, Daniel Moreira, José Carlos Moura Jorge, Adalberto Menezes Lorga Filho, Luiz Bodanese, Marcelo Westerlund Montera, Carlos Henrique Del Carlo, Jamil Abdalla Saad, Fernando Augusto Alves da Costa, Renato Lopes, Gilson Roberto de Araújo, Euler Roberto Manenti, Jose Francisco Kerr Saraiva, João Carlos Ferreira Braga, Alexandre Negri, Carlos Moncada, Dalton Precoma, Fernando Roquette, Gilmar Reis, Roberto Álvaro Ramos Filho, Estêvão Lanna Figueiredo, Roberto Vieira Botelho, Cláudio Munhoz da Fontoura Tavares, Helius Carlos Finimundi, Adriano Kochi, César Cássio Broilo França, Fábio Alban, Guido Bernardo Aranha Rosito, João Batista de Moura Xavier Moraes Junior, Rogério Tadeu Tumelero, Lilia Maia, Roberto Simões de Almeida, Ney Carter do Carmo Borges, Luís Gustavo Gomes Ferreira, Ramón Corbalán Benjamin Aleck Joseh Stockins Fernandez, Humberto Montecinos, Fernando Lanas, Martín Larico Gómez, Carlos Astudillo, Carlos Conejeros, Patricio Marin Cuevas, Alejandro Forero, Claudio Bugueño Gutiérrez, Juan Aguilar, Sergio Potthoff Cardenas, German Eggers, Cesar Houzvic, Carlos Rey, Germán Arriagada, Gustavo Charme Vilches, Carlos Jerjes Sanchez Diaz Jesus Jaime Illescas Diaz, Raul Leal Cantu, Maria Guadalupe Ramos Zavala, Ricardo Cabrera Jardines, Nilda Espinola Zavaleta, Enrique Lopez Rosas, Guillermo Antonio Llamas Esperón, Gerardo Pozas, Ernesto Cardona Muñoz, Norberto Matadamas Hernandez, Adolfo Leyva Rendon, Norberto Garcia Hernandez, Manuel de los Rios Ibarra, Luis Ramon Virgen Carrillo, David Lopez Villezca, Carlos Hernandez Herrera, Juan Jose Lopez Prieto, Rodolfo Gaona Rodriguez, Efrain Villeda Espinosa, David Flores Martinez, Jose Velasco Barcena, Omar Fierro Fierro, Ignacio Rodriguez Briones, Jose Luis Leiva Pons, Humberto Alvarez Lopez, Rafael Olvera Ruiz, Carlos Gerardo Cantu Brito, Eduardo Julian Jose Roberto Chuquiure Valenzuela, Roxana Reyes Sanchez, Alberto Esteban Bazzoni Ruiz, Oscar Martin Lopez Ruiz, Roberto Arriaga Nava, Jesus David Morales Cerda, Pedro Fajardo Campos, Mario Benavides Gonzalez, Marianne Brodmann Kurt Lenz, Claus Hagn, Johannes Foechterle, Heinz Drexel, Kurt Huber, Andrea Podczeck-Schweighofer, Michael Winkler, Bruno Schneeweiss, Alfons Gegenhuber, Wilfried Lang, Sabine Eichinger-Hasenauer, Peter Kaserer, Josef Sykora, Heribert Rasch, Bernhard Strohmer, Luc Capiau Geert Vervoort, Bart Wollaert, Geert Hollanders, Jan Vercammen, Dirk Faes, Yohan Balthazar, Marc Delforge, Olivier Xhaet, Harry Striekwold, John Thoeng, Kurt Hermans, Georges Mairesse, Wim Anné, Ivan Blankoff, Michel Beutels, Stefan Verstraete, Peter Vandergoten, Philippe Purnode, Pascal Godart, Tim Boussy, Philippe Desfontaines, Alex Heyse, Joeri Voet, Axel De Wolf, Eva Zidkova Petr Jansky, Rudolf Spacek, Vilma Machova, Ondrej Ludka, Josef Olsr, Lubos Kotik, Blazej Racz, Richard Ferkl, Jan Hubac, Ilja Kotik, Zdenek Monhart, Hana Burianova, Ondrej Jerabek, Jana Pisova, Iveta Petrova, Vratislav Dedek, Michaela Honkova, Petr Podrazil, Petr Reichert, Jindrich Spinar, Miroslav Novak, Vaclav Durdil, Katarina Plocova, Jiri Lastuvka, Jørn Nielsen Steen Husted, Helena Dominguez, Ulrik Hintze, Søren Rasmussen, Næstved Sygehus, Arne Bremmelgaard, John Markenvard, Jan Børger, Jorgen Solgaard, Ebbe Eriksen, Thomas Løkkegaard, Michael Bruun, Jacob Mertz, Morten Schou, Michael Olsen, Pekka Raatikainen Carmela Viitanen, Franck Paganelli Joël Ohayon, Frédéric Casassus, Michel Galinier, Yannick Gottwalles, Philippe Loiselet, Jean-Joseph Muller, Mohamed Bassel Koujan, André Marquand, Sylvain Destrac, Olivier Piot, Nicolas Delarche, Jean-Pierre Cebron, Maxime Guenoun, Dominique Guedj-Meynier, A. G. Lokesh, Mathieu Zuber, Pierre Amarenco, Emmanuel Ellie, James Kadouch, Pierre-Yves Fournier, Jean-Pierre Huberman, Nestor Lemaire, Gilles Rodier, Xavier Vandamme, Igor Sibon, Jean-Philippe Neau, Marie Hélène Mahagne, Antoine Mielot, Marc Bonnefoy, Jean-Baptiste Churet, Vincent Navarre, Frederic Sellem, Gilles Monniot, Jean-Paul Boyes, Bernard Doucet, Michel Martelet, Désiré Obadia, Bernard Crousillat, Joseph Mouallem, Etienne Bearez, Jean Philippe Brugnaux, Alain Fedorowsky, Pierre Nazeyrollas, Jean-Baptiste Berneau, Frédéric Chemin, Sebastien Schellong Harald Darius, Georg Koeniger, Andreas Kopf, Uwe Gerbaulet, Bernd-Thomas Kellner, Thomas Schaefer, Jan Purr, Enno Eißfeller, Heinz-Dieter Zauzig, Peter Riegel, Christoph Axthelm, Gerd-Ulrich Heinz, Holger Menke, Andreas Pustelnik, Stefan Zutz, Wolfgang Eder, Guenter Rehling, Dirk Glatzel, Norbert Ludwig, Petra Sandow, Henning Wiswedel, Cosmas Wildenauer, Steffen Schoen, Toralf Schwarz, Adyeri Babyesiza, Maximilian Kropp, Hans-Hermann Zimny, Friedhelm Kahl, Andreas Caspar, Sabine Omankowsky, Torsten Laessig, Hermann-Josef Hartmann, Gunter Lehmann, Hans-Walter Bindig, Gunter Hergdt, Dietrich Reimer, Joachim Hauk, Holger Michel, Praxis Dres. Werner Erdle, Wilfried Dorsch, Janna Dshabrailov, Karl-Albrecht Rapp, Reinhold Vormann, Thomas Mueller, Peter Mayer, Uwe Horstmeier, Volker Eissing, Heinz Hey, Heinz Leuchtgens, Volker Lilienweiss, Heiner Mueller, Christian Schubert, Herrmann Lauer, Thomas Buchner, Gunter Brauer, Susanne Kamin, Karsten Mueller, Sylvia Baumbach, Muwafeg Abdel-Qader, Hans-Holger Ebert, Carsten Schwencke, Peter Bernhardt, Laszlo Karolyi, Britta Sievers, Wilhelm Haverkamp, Jens-Uwe Roehnisch, Andras Vertes Gabor Szantai, Andras Matoltsy, Nikosz Kanakaridisz, Zoltan Boda, Erno Kis, Balazs Gaszner, Ferenc Juhasz, Gizella Juhasz, Sandor Kancz, Zoltan Laszlo, Zsolt May, Bela Merkely, Ebrahim Noori, Tamas Habon, Peter Polgar, Gabriella Szalai, Sandor Vangel, Andras Nagy, Gabriella Engelthaler, Judit Ferenczi, Mihaly Egyutt, Giuliana Martini Leone Maria Cristina, Eros Tiraferri, Rita Santoro, Sophie Testa, Giovanni Di Minno, Marco Moia, Teresa Maria Caimi, Maria Tessitori, Roberto Cappelli, Daniela Poli, Roberto Quintavalla, Franco Cosmi, Raffaele Fanelli, Vincenzo Oriana, Raffaele Reggio, Roberto Santi, Leonardo Pancaldi, Raimondo De Cristofaro, Giuliana Guazzaloca, Angelo De Blasio, Jorge Salerno Uriate, Flavia Lillo, Enrico Maria Pogliani, Grzegorz Bilo, Michele Accogli, Antonio Mariani, Mauro Feola, Arturo Raisaro, Luciano Fattore, Andrea Mauric, Fabrizio Germini, Luca Tedeschi, Maria Settimi, Sergio Nicoli, Paolo Ricciarini, Antonio Argena, Paolo Ronchini, Claudio Bulla, Filippo Tradati, Massimo Volpe, Maria D’Avino, Maria Grazia Bongiorni, Silva Severi, Alessandro Capucci, Corrado Lodigiani, Enrico Salomone, Gaetano Serviddio, Claudio Tondo, Paolo Golino, Carmine Mazzone, Saverio Iacopino, Hugo ten Cate J. H. Ruiter, Andreas Lucassen, Henk Adriaansen, Maarten Bongaerts, Mathijs Pieterse, Coen van Guldener, Johannes Herrman, S. H. K. P. R. Nierop, Pieter Hoogslag, Walter Hermans, B. E. Groenemeijer, W. Terpstra, Cees Buiks, L. V. A. Boersma, Eivind Berge Per Anton Sirnes, Erik Gjertsen, Torstein Hole, Knut Erga, Arne Hallaråker, Gunnar Skjelvan, Anders Østrem, Beraki Ghezai, Arne Svilaas, Peter Christersson, Torbjørn Øien, Svein Høegh Henrichsen, Jan Erik Otterstad, Jan Berg-Johansen, Janina Stepinska Andrzej Gieroba, Malgorzata Biedrzycka, Michal Ogorek, Beata Wozakowska-Kaplon, Krystyna Loboz-Grudzien, Wieslaw Supinski, Jerzy Kuzniar, Roman Zaluska, Jaroslaw Hiczkiewicz, Lucyna Swiatkowska-Byczynska, Lech Kucharski, Marcin Gruchala, Piotr Minc, Maciej Olszewski, Grzegorz Kania, Malgorzata Krzciuk, Zbigniew Lajkowski, Bozenna Ostrowska-Pomian, Jerzy Lewczuk, Elzbieta Zinka, Agnieszka Karczmarczyk, Malgorzata Chmielnicka-Pruszczynska, Iwona Wozniak-Skowerska, Grzegorz Opolski, Marek Bronisz, Marcin Ogorek, Grazyna Glanowska, Piotr Ruszkowski, Grzegorz Skonieczny, Ryszard Sciborski, Boguslaw Okopien, Piotr Kukla, Krzysztof Galbas, Krzysztof Cymerman, Jaroslaw Jurowiecki, Pawel Miekus, Waldemar Myszka, Stanislaw Mazur, Roman Lysek, Jacek Baszak, Teresa Rusicka-Piekarz, Grzegorz Raczak, Ewa Domanska, Jadwiga Nessler, Jozef Lesnik, Vera Eltishcheva Roman Libis, Gadel Kamalov, Dmitry Belenky, Liudmila Egorova, Alexander Khokhlov, Eduard Yakupov, Dmitry Zateyshchikov, Olga Barbarash, Olga Miller, Evgeniy Mazur, Konstantin Zrazhevskiy, Tatyana Novikova, Yulia Moiseeva, Elena Polkanova, Konstantin Sobolev, Maria Rossovskaya, Yulia Shapovalova, Alla Kolesnikova, Konstantin Nikolaev, Oksana Zemlianskaia, Anna Zateyshchikova, Victor Kostenko, Sergey Popov, Maria Poltavskaya, Anton Edin, Elena Aleksandrova Oksana Drapkina, Alexander Vishnevsky, Oleg Nagibovich, Petr Chizhov, Svetlana Rachkova, Mikhail Sergeev, Borys Kurylo, Alexey Ushakov, Xavier Vinolas Pere Alvarez Garcia, Maria Fernanda Lopez Fernandez, Luis Tercedor Sanchez, Salvador Tranche Iparraguirre, Pere Toran Monserrat, Emilio Marquez Contreras, Jordi Isart Rafecas, Juan Motero Carrasco, Pablo Garcia Pavia, Casimiro Gomez Pajuelo, Luis Miguel Rincon Diaz, Luis Fernando Iglesias Alonso, Angel Grande Ruiz, Jordi Merce Klein, Jose Ramon Gonzalez Juanatey, Ines Monte Collado, Herminia Palacin Piquero, Carles Brotons Cuixart, Esther Fernandez Escobar, Joan Bayo i Llibre, Cecilia Corros Vicente, Manuel Vida Gutierrez, Francisco Epelde Gonzalo, Carlos Alexandre Almeida Fernandez, Encarnacion Martinez Navarro, Juan Jose Montero Alia, Maria Barreda Gonzalez, Maria Angels Moleiro Oliva, Jose Iglesias Sanmartin, Mercedes Jimenez Gonzalez, Maria del Mar Rodriguez Alvarez, Juan Herreros Melenchon, Tomas Ripoll Vera, Manuel Jimenez Navarro, Maria Vazquez Caamano, Maria Fe Arcocha Torres, Gonzalo Marcos Gomez, Andres Iniguez Romo, Miguel Angel Prieto Diaz, Mårten Rosenqvist Alexander Wirdby, Jan Lindén, Kerstin Henriksson, Micael Elmersson, Arnor Egilsson, Ulf Börjesson, Gunnar Svärd, Bo Liu, Anders Lindh, Lars-Bertil Olsson, Mikael Gustavsson, Lars Andersson, Lars Benson, Claes Bothin, Ali Hajimirsadeghi, Björn Martinsson, Marianne Ericsson, Åke Ohlsson, Håkan Lindvall, Peter Svensson, Katarina Thörne, Hans Händel, Pyotr Platonov, Fredrik Bernsten, Ingar Timberg, Milita Crisby, Jan-Erik Karlsson, Agneta Andersson, Lennart Malmqvist, Johan Engdahl, Jörgen Thulin, Aida Hot-Bjelak, Steen Jensen, Per Stalby, Jan Steffel Johann Debrunner, Juerg H. Beer, Dipen Shah, Iurii Rudyk Vira Tseluyko, Oleksandr Karpenko, Svitlana Zhurba, Igor Kraiz, Oleksandr Parkhomenko, Iryna Kupnovytska, Nestor Seredyuk, Yuriy Mostovoy, Oleksiy Ushakov, Olena Koval, Igor Kovalskiy, Yevgeniya Svyshchenko, Oleg Sychov, Mykola Stanislavchuk, Andriy Yagensky, Susanna Tykhonova, Ivan Fushtey, Will Murdoch Naresh Chauhan, Daryl Goodwin, Louise Lumley, Ramila Patel, Philip Saunders, Bennett Wong, Alex Cameron, Niranjan Patel, P. Jhittay, Andrew Ross, M. S. Kainth, Karim Ladha, Kevin Douglas, Gill Pickavance, Joanna McDonnell, Laura Handscombe, Trevor Gooding, Helga Wagner, Colin Bradshaw, Catherine Bromham, Kevin Jones, Shoeb Suryani, Richard Coates, Bhupinder Sarai, W. Willcock, S. Sircar, John Cairns, A. Gilliand, Roman Bilas, E. Strieder, Peter Hutchinson, Anne Wakeman, Michael Stokes, Graham Kirby, Bhaskhar Vishwanathan, Nigel Bird, Paul Evans, M. Clark, John Bisatt, Jennifer Litchfield, E. Fisher, Tim Fooks, Richard Kelsall, Neil Paul, Elizabeth Alborough, Michael Aziz, C. Ramesh, Pete Wilson, Simon Franklin, Sue Fairhead, Julian Thompson, Hasan Chowan, Gary Taylor, Dawn Tragen, Matt Parfitt, Claire Seamark, Carolyn Paul, Mark Richardson, Angus Jefferies, Helen Sharp, Hywel Jones, Claire Giles, Matthew Bramley, Philip Williams, Jehad Aldegather, Simon Wetherell, William Lumb, Phil Evans, Frances Scouller, Neil Macey, Stephen Rogers, Yvette Stipp, Richard West, Philip Pinney, Paul Wadeson, John Matthews, Preeti Pandya, Andrew Gallagher, T. Railton, Emyr Davies, Jonathan McClure, Marc Jacobs, Claire Hutton, R. Thompson, Bijoy Sinha, Keith Butter, Susan Barrow, Helen Little, David Russell, Ulka Choudhary, Ikram Haq, Paul Ainsworth, Claire Jones, Phil Weeks, Jane Eden, Lisa Gibbons, Janet Glencross, Alison MacLeod, K. Poland, Conor Mulolland, A. Warke, Paul Conn, D. Burns, R. Smith, R. Kamath, Jonathan Webster, Ian Hodgins, Stephen Vercoe, Paul Roome, Hilary Pinnock, Jayesh Patel, Amar Ali, Nigel Hart, Richard Davies, Nigel De-Sousa, Catherine Neden, Mark Danielsen, Purnima Sharma, Sophia Galloway, Charlotte Hawkins, Raife Oliver, Martin Aylward, Mira Pattni, Gordon Irvine, Shahid Ahmad, Catherine Rothwell, Fiaz Choudhary, Sabrina Khalaque, Stephanie Short, Sharon Peters, Warwick Coulson, Neil Roberts, Amy Butler Steven Coates, Ben Ward, Daniel Jackson, Steve Walton, Diane Shepherd, Toh Wong, Mark Boon, Melanie Deacon, David Cornelius, Sarah Davies, Ben Frankel, Nick Hargreaves, Henry Choi, Jon Sumner, Tim Myhill, Salah Estifanos, Diane Geatch, Justin Wilkinson, Richard Veale, Karen Forshaw, Rob Hirst, Kashif Zaman, Catherine Liley, Rebecca Wastling, Paul McEleny, Andre Beattie, Philip Cooke, Mike Wong, Mark Pugsley, Chaminda Dooldeniya, Greg Rogers, James Bennett, Polly Jacobs, Rajesh Muvva, Matthew Adam, Robin Fox, Nicolas Thomas, Simon Cartwright, Rory Reed, Simon Randfield, Christine A’Court, Ann Flynn, Andrew Halpin, Simon Dobson, Louise Lomax, Minnal Nadaph, Iain Munro, Jane Goram, Helen Stoddart, Phil Simmons, John Shewring, Emma Bowen-Simpkins, Mark Rickenbach, Adam Blenkhorn Bhuwanendu Singh, Penny Astridge, William van Gaal, Walter Abhayaratna, Philip Thomson, Ron Lehman, Jens Kilian, David Coulshed, Andrei Catanchin, David Colquhoun, Hosen Kiat, David Eccleston, John French, Bronte Ayres, Peter Blombery, Thanh Phan, James Rogers, David O’Donnell, Sang Cheol Bae, Harry Gibbs, Patrick Carroll, Greg Starmer, Margaret Arstall, Maurits Binnekamp, Astin Lee, John Eikelboom Robert Luton, Milan Gupta, Amritanshu Shekhar Pandey, Stephen Cheung, Rolland Leader, Philippe Beaudry, Félix Ayala-Paredes, Joseph Berlingieri, John Heath, Germain Poirier, Miranda du Preez, Bradley Schweitzer, Reginald Nadeau, Ripple Dhillon, Tomasz Hruczkowski, Andrea Lavoie, Ratika Parkash, James Cha, Benoit Coutu, Paul MacDonald, Brian Ramjattan, Jorge Bonet, Saul Vizel, Paul Angaran, Sameh Fikry, Ahmed Mowafy Azza Katta, Mazen Tawfik, Moustafa Nawar, Mohamed Sobhy, Seif Kamal Abou Seif, Tarek Khairy, Ahmed Abd El-Aziz, Nasser Taha, Ashraf Reda, Atef Elbahry, Mohamed Setiha, Mohamed Gamal El Din, Magdi Elkhadem, Adel El-Etreby, David Kettles Junaid Bayat, Heidi Siebert, Adrian Horak, Ynez Kelfkens, Riaz Garda, Thayabran Pillay, Michele Guerra, Louis van Zyl, Hendrik Theron, Andrew Murray, Rikus Louw, Deon Greyling, Pindile Mntla, Siddique Ismail, Fayzal Ahmed, Johannes Engelbrecht, Shambu Maharajh, Wessel Oosthuysen, Rehana Loghdey, Veronica Ueckermann, Wael AlAl Mahmeed AbdullahNaeemi, Ghazi Yousef, Nooshin Bazargani, Munther AlOmairi, Rajan Maruthanayagam, Rupesh Singh, Ahmed Naguib, Mohamed Ibrahim, Amrish Agrawal, Mukesh Nathani, Ehab M. Esheiba, Adel Wassef, Rajeev Gupta, Michael Cox Scott Beach, Peter Duffy, Stephen Falkowski, Kevin Ferrick, Miguel Franco, W. Michael Kutayli, Annette Quick, Niraj Sharma, Vance Wilson, Stephen Miller, Mark Alberts, Edwin Blumberg, Roddy Canosa, Ted Gutowski, Rodney Ison, Jorge Garcia, Paul Mullen, Howard Noveck, Pamela Rama, Rajneesh Reddy, Marcus Williams, Daniel Nishijima, Keith Ferdinand, Ihsan Haque, Robert Mendelson, Sridevi Pitta, Daniel Theodoro, Charles Treasure, Moustafa Moustafa, Cas Cader, Walter Pharr, Alisha Oropallo, George Platt, Jaspal Gujral, James Welker, and Firas Koura
- Abstract
Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is a worldwide non-interventional study of stroke prevention in patients with non-valvular AF. Methods and results: 52,080 patients with newly diagnosed AF were prospectively enrolled from 2010 to 2016. 4121 (7.9%) of these patients were recruited in DACH [Germany (n = 3567), Austria (n = 465) and Switzerland (n = 89) combined], and 47,959 patients were from 32 countries in other regions worldwide (ORW). Hypertension was most prevalent in DACH and ORW (85.3% and 75.6%, respectively). Diabetes, hypercholesterolaemia, carotid occlusive disease and vascular disease were more prevalent in DACH patients vs ORW (27.6%, 49.4%, 5.8% and 29.0% vs 21.7%, 40.9%, 2.8% and 24.5%). The use of non-vitamin K antagonist oral anticoagulants (NOACs) increased more in DACH over time. Management of vitamin K antagonists was suboptimal in DACH and ORW (time in therapeutic range of INR ≥ 65% in 44.6% and 44.4% of patients or ≥ 70% in 36.9% and 36.0% of patients, respectively). Adjusted rates of cardiovascular mortality and MI/ACS were higher in DACH while non-haemorrhagic stroke/systemic embolism was lower after 2-year follow-up. Conclusions: Similarities and dissimilarities in AF management and clinical outcomes are seen in DACH and ORW. The increased use of NOAC was associated with a mismatch of risk-adapted anticoagulation (over-and-undertreatment) in DACH. Suboptimal control of INR requires educational activities in both regional groups. Higher rates of cardiovascular death in DACH may reflect the higher risk profile of these patients and lower rates of non-haemorrhagic stroke could be associated with increased NOAC use. Graphical abstract: [Figure not available: see fulltext.].
- Published
- 2023
23. Atrial Fibrillation can adversely impact Heart Failure with Preserved Ejection Fraction by its association with Heart Failure Progression and Mortality: A Post-Hoc Propensity Score–Matched Analysis of the TOPCAT Americas Trial
- Author
-
Sanjeev Saksena, April Slee, Andrea Natale, Dhanunjaya R Lakkireddy, Dipen Shah, Luigi Di Biase, Thorsten Lewalter, Rangadham Nagarakanti, and Pasquale Santangeli
- Subjects
Physiology (medical) ,Cardiology and Cardiovascular Medicine - Abstract
Aims Prevalent atrial fibrillation (AF) is associated with excess cardiovascular (CV) death (D) and hospitalizations (H) in heart failure (HF) with preserved ejection fraction (pEF). We evaluated if it had an independent role in excess CVD in HFpEF and studied its impact on cause-specific mortality and HF morbidity. Methods and results We used propensity score–matched (PSM) cohorts from the TOPCAT Americas trial to account for confounding by other co-morbidities. Two prevalent AF presentations at study entry were compared: (i) subjects with Any AF event by history or on electrocardiogram (ECG) with PSM subjects without an AF event and (ii) subjects in AF on ECG with PSM subjects in sinus rhythm. We analyzed cause-specific modes of death and HF morbidity during a mean follow-up period of 2.9 years. A total of 584 subjects with Any AF event and 418 subjects in AF on ECG were matched. Any AF was associated with increased CVH [hazard ratio (HR) 1.33, 95% confidence interval (CI) 1.11–1.61, P = 0.003], HFH (HR 1.44, 95% CI 1.12–1.86, P = 0.004), pump failure death (PFD) (HR 1.95, 95% CI 1.05–3.62, P = 0.035), and HF progression from New York Heart Association (NYHA) classes I/II to III/IV (HR 1.30, 95% CI 1.04–1.62, P = 0.02). Atrial fibrillation on ECG was associated with increased risk of CVD (HR 1.46, 95% CI 1.02–2.09, P = 0.039), PFD (HR 2.21, 95% CI 1.11–4.40, P = 0.024), and CVH and HFH (HR 1.37, 95% CI 1.09–1.72, P = 0.006 and HR 1.65, 95% CI 1.22–2.23, P = 0.001, respectively). Atrial fibrillation was not associated with risk of sudden death. Both Any AF and AF on ECG cohorts were associated with PFD in NYHA class III/IV HF. Conclusion Prevalent AF can be an independent risk factor for adverse CV outcomes by its selective association with worsening HF, HFH, and PFD in HFpEF. Prevalent AF was not associated with excess sudden death risk in HFpEF. Atrial fibrillation was also associated with HF progression in early symptomatic HFpEF and PFD in advanced HFpEF. Trial registration TOPCAT trial is registered at www.clinicaltrials.gov:identifier NCT00094302.
- Published
- 2023
- Full Text
- View/download PDF
24. Anomalies de l’ECG secondaires à une lésion du système nerveux central
- Author
-
Nicolas Johner, Marc Arcens, and Dipen Shah
- Subjects
General Medicine - Published
- 2022
- Full Text
- View/download PDF
25. Impact of SMART Pass filter in patients with ajmaline-induced Brugada syndrome and subcutaneous implantable cardioverter-defibrillator eligibility failure: results from a prospective multicentre study
- Author
-
Alessandro Vicentini, Haran Burri, Andrea Demarchi, Maria Luce Caputo, Pedro Brugada, Antonio Scalone, Carlo de Asmundis, Ilaria Passarelli, Mehdi Namdar, Fabio Cattaneo, Paola Berne, Dipen Shah, Tardu Özkartal, Gavino Casu, Angelo Auricchio, Giulio Conte, Francesca Salghetti, Stefano Mameli, Gaetano M. De Ferrari, Catherine Klersy, Clinical sciences, Heartrhythmmanagement, and Cardio-vascular diseases
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,sudden cardiac death ,Sudden cardiac death ,Electrocardiography ,03 medical and health sciences ,QRS complex ,0302 clinical medicine ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,In patient ,SMART Pass ,Prospective Studies ,cardiovascular diseases ,030212 general & internal medicine ,Brugada Syndrome ,Brugada syndrome ,Eligibility ,Ajmaline ,business.industry ,Arrhythmias, Cardiac ,Middle Aged ,medicine.disease ,Implantable cardioverter-defibrillator ,Defibrillators, Implantable ,Clinical trial ,Subcutaneous implantable cardioverter-defibrillator ,Filter (video) ,Screening ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Aims Ajmaline challenge can unmask subcutaneous implantable cardioverter-defibrillator (S-ICD) screening failure in patients with Brugada syndrome (BrS) and non-diagnostic baseline electrocardiogram (ECG). The efficacy of the SMART Pass (SP) filter, a high-pass filter designed to reduce cardiac oversensing (while maintaining an appropriate sensing margin), has not yet been assessed in patients with BrS. The aim of this prospective multicentre study was to investigate the effect of the SP filter on dynamic Brugada ECG changes evoked by ajmaline and to assess its value in reducing S-ICD screening failure in patients with drug-induced Brugada ECGs. Methods and results The S-ICD screening with conventional automated screening tool (AST) was performed during ajmaline challenge in subjects with suspected BrS. The S-ICD recordings were obtained before, during and after ajmaline administration and evaluated by the means of a simulation model that emulates the AST behaviour with and without SP filter. A patient was considered suitable for S-ICD if at least one sensing vector was acceptable in all tested postures. A sensing vector was considered acceptable in the presence of QRS amplitude >0.5 mV, QRS/T-wave ratio >3.5, and sense vector score >100. Of the 126 subjects (mean age: 42 ± 14 years, males: 61%, sensing vectors: 6786), 46 (36%) presented with an ajmaline-induced Brugada type 1 ECG. Up to 30% of subjects and 40% of vectors failed the screening during the appearance of Brugada type 1 ECG evoked by ajmaline. The S-ICD screening failure rate was not significantly reduced in patients with Brugada ECGs when SP filter was enabled (30% vs. 24%). Similarly, there was only a trend in reduction of vector-failure rate attributable to the SP filter (from 40% to 36%). The most frequent reason for screening failure was low QRS amplitude or low QRS/T-wave ratio. None of these patients was implanted with an S-ICD. Conclusion Patients who pass the sensing screening during ajmaline can be considered good candidates for S-ICD implantation, while those who fail might be susceptible to sensing issues. Although there was a trend towards reduction of vector sensing failure rate when SP filter was enabled, the reduction in S-ICD screening failure in patients with Brugada ECGs did not reach statistical significance. Clinical trial registration https://clinicaltrials.gov Unique Identifier NCT04504591.
- Published
- 2021
- Full Text
- View/download PDF
26. EHRA expert consensus statement on arrhythmic mitral valve prolapse and mitral annular disjunction complex in collaboration with the ESC Council on valvular heart disease and the European Association of Cardiovascular Imaging endorsed cby the Heart Rhythm Society, by the Asia Pacific Heart Rhythm Society, and by the Latin American Heart Rhythm Society
- Author
-
Avi Sabbag, Benjamin Essayagh, Juan David Ramírez Barrera, Cristina Basso, Ana Berni, Bernard Cosyns, Jean-Claude Deharo, Thomas Deneke, Luigi Di Biase, Maurice Enriquez-Sarano, Erwan Donal, Katsuhiko Imai, Han S Lim, Nina Ajmone Marsan, Mohit K Turagam, Petr Peichl, Sunny S Po, Kristina Hermann Haugaa, Dipen Shah, Marta de Riva Silva, Philippe Bertrand, Magdi Saba, Marc Dweck, Santiago Nava Townsend, Tachapong Ngarmukos, Guilherme Fenelon, Pasquale Santangeli, Leyla Elif Sade, Domenico Corrado, Pier Lambiase, Prashanthan Sanders, Etienne Delacrétaz, Arshad Jahangir, Elizabeth S Kaufman, Daljeet Kaur Saggu, Luc Pierard, Victoria Delgado, Patrizio Lancellotti, Clinical sciences, Cardio-vascular diseases, and Cardiology
- Subjects
Sudden cardiac death ,Physiology (medical) ,Mitral annular disjunction ,Ventricular arrhythmia ,Mitral valve prolapse ,Risk stratification ,Cardiology and Cardiovascular Medicine ,Risk stratification - Published
- 2022
27. Novel bleeding risk score for patients with atrial fibrillation on oral anticoagulants, including direct oral anticoagulants
- Author
-
Stefan Osswald, Luise Adam, Jacques Donzé, Giorgio Moschovitis, Stefanie Aeschbacher, Matthias Schwenkglenks, Cinzia Del‐Giovane, Jürg H. Beer, Drahomir Aujesky, Richard Kobza, Carmen Floriani, Leo H. Bonati, Michael Kühne, Dipen Shah, Urs Fischer, Laurent Roten, David Conen, Nicolas Rodondi, Jürg Schläpfer, Lamprini Syrogiannouli, Christine Baumgartner, Martin Feller, Daniel Segna, Peter Amman, University of Zurich, and Rodondi, Nicolas
- Subjects
Male ,medicine.medical_specialty ,2720 Hematology ,Administration, Oral ,610 Medicine & health ,Hemorrhage ,030204 cardiovascular system & hematology ,SWISS-AF ,direct oral anticoagulants ,atrial fibrillation ,bleeding risk ,oral anticoagulants ,11459 Center for Molecular Cardiology ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,In patient ,Prospective Studies ,Prospective cohort study ,Aged ,Aged, 80 and over ,Framingham Risk Score ,Anticoagulants ,Cancer ,Atrial fibrillation ,10060 Epidemiology, Biostatistics and Prevention Institute (EBPI) ,Hematology ,medicine.disease ,Confidence interval ,3. Good health ,Stroke ,Brier score ,570 Life sciences ,biology ,Female ,Switzerland ,Cohort study - Abstract
OBJECTIVE Balancing bleeding risk and stroke risk in patients with atrial fibrillation (AF) is a common challenge. Though several bleeding risk scores exist, most have not included patients on direct oral anticoagulants (DOACs). We aimed at developing a novel bleeding risk score for patients with AF on oral anticoagulants (OAC) including both vitamin K antagonists (VKA) and DOACs. METHODS We included patients with AF on OACs from a prospective multicenter cohort study in Switzerland (SWISS-AF). The outcome was time to first bleeding. Bleeding events were defined as major or clinically relevant non-major bleeding. We used backward elimination to identify bleeding risk variables. We derived the score using a point score system based on the β-coefficients from the multivariable model. We used the Brier score for model calibration ( 75 years, history of cancer, prior major hemorrhage, and arterial hypertension remained in the final prediction model. The Brier score was 0.23 (95% confidence interval [CI] 0.19-0.27), the c-statistic at 12 months was 0.71 (95% CI 0.63-0.80). CONCLUSION In this prospective cohort study of AF patients and predominantly DOAC users, we successfully derived a bleeding risk prediction model with good calibration and discrimination.
- Published
- 2021
- Full Text
- View/download PDF
28. Right Atrial Complexity Evolves With Stepwise Left-Sided Persistent Atrial Fibrillation Substrate Ablation and Predicts Outcomes
- Author
-
Nicolas Johner, Mehdi Namdar, and Dipen Shah
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Catheter ablation ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Heart Atria ,030212 general & internal medicine ,Vein ,Coronary sinus ,business.industry ,Hazard ratio ,Atrial fibrillation ,Ablation ,medicine.disease ,Confidence interval ,Sample entropy ,medicine.anatomical_structure ,Pulmonary Veins ,Catheter Ablation ,Cardiology ,Electrophysiologic Techniques, Cardiac ,business - Abstract
Objectives This study sought to study the relation between outcomes of modified stepwise atrial fibrillation (AF) substrate ablation and dynamic electrogram characteristics in the coronary sinus (CS) and right atrium (RA). Background Identifying patients with persistent AF who will benefit from limited lesion sets versus those requiring extensive substrate modification is challenging. Methods We studied 70 patients undergoing persistent AF ablation, 43 with acute success (successful ablation [sABL], AF termination, or noninducibility) and 27 with failure (failed ablation [fABL], no termination, or induced AF of >5 minutes). Dominant frequency (DF) and sample entropy (SampEn, increasing with signal complexity) were measured on 30-second recordings of wide-coverage simultaneous RA and CS electrograms during baseline AF and induced AF post–pulmonary vein isolation and after left-sided electrogram-guided ablation steps (on the CS with or without the left atrium [LA]). Results At baseline AF, patients with sABL exhibited lower RA SampEn (p = 0.023) and lower CS DF (p = 0.030) compared to fABL. A positive RA-to-CS SampEn gradient predicted ablation failure (48% vs. 19% for patients in fABL vs. sABL; p = 0.015). A positive RA-to-CS DF gradient developed in patients with fABL after extra–pulmonary vein substrate modification, unlike patients with sABL (p = 0.0008). At 24 months, 76% of patients were AF free, and 68% were arrhythmia free. sABL was associated with fewer AF recurrences (hazard ratio: 0.31; 95% confidence interval: 0.12–0.84; p = 0.021). A negative RA-to-CS SampEn gradient at baseline was associated with freedom from AF (–0.14 ± 0.19 vs. 0.04 ± 0.18; p = 0.002). Conclusions RA greater than CS electrogram complexity gradients at baseline or developing during ablation are associated with unfavorable acute and long-term outcomes of persistent AF ablation. These parameters allow monitoring of the effects of left-sided substrate ablation and, therefore, a rational choice of additional RA substrate modification.
- Published
- 2020
- Full Text
- View/download PDF
29. [Electrocardiographic abnormalities in the setting of acute central nervous system pathology]
- Author
-
Nicolas, Johner, Marc, Arcens, and Dipen, Shah
- Subjects
Central Nervous System ,Electrocardiography ,Myocardial Infarction ,Humans ,Arrhythmias, Cardiac ,Heart - Abstract
Up to 90% of patients with acute central nervous system lesions, such as stroke, exhibit secondary ECG abnormalities, including ST elevation/depression, T wave inversion, prominent U wave, prolonged QTc interval, sinus bradycardia/pause and atrioventricular block. The pathophysiology involves autonomic nervous system disturbance resulting in altered ventricular repolarization gradients, or even myocardial lesions. Clinical assessment aims at distinguishing asymptomatic neurogenic ECG abnormalities from organic heart conditions such as Takotsubo syndrome, myocardial infarction and chronic coronary syndromes. Serial ECG, cardiac biomarkers and echocardiography should be performed, followed by targeted work-up in selected patients. Prolonged QT, arrhythmias or hemodynamic compromise require continuous monitoring and standard management.Jusqu’à 90 % des patients souffrant de lésions neurologiques aiguës telles que l’AVC présentent des anomalies ECG neurogènes incluant : sus ou sous-décalage ST, onde T inversée, onde U proéminente, prolongement du QTc, bradycardie/pause sinusale et bloc atrioventriculaire. Leur cause semble être une dérégulation neurovégétative provoquant des gradients de repolarisation ventriculaire, voire des lésions myocardiques. Le bilan doit différencier les nombreux patients avec ECG neurogène asymptomatique de ceux présentant une cardiopathie telle qu’un syndrome de Takotsubo, un infarctus ou une maladie coronarienne stable. Le bilan inclut ECG sérié, biomarqueurs cardiaques et échocardiographie, suivis d’un bilan ciblé chez des patients sélectionnés. Un QT long, des arythmies ou une instabilité hémodynamique imposent un monitoring et les mesures habituelles.
- Published
- 2022
30. The dimerization mechanism of the N-terminal domain of spider silk proteins is conserved despite extensive sequence divergence
- Author
-
Médoune, Sarr, Kristine, Kitoka, Kellie-Ann, Walsh-White, Margit, Kaldmäe, Rimants, Metlāns, Kaspar, Tārs, Alessandro, Mantese, Dipen, Shah, Michael, Landreh, Anna, Rising, Jan, Johansson, Kristaps, Jaudzems, and Nina, Kronqvist
- Subjects
Protein Domains ,Silk ,Animals ,Spiders ,Hydrogen-Ion Concentration ,Fibroins ,Dimerization ,Conserved Sequence - Abstract
The N-terminal (NT) domain of spider silk proteins (spidroins) is crucial for their storage at high concentrations and also regulates silk assembly. NTs from the major ampullate spidroin (MaSp) and the minor ampullate spidroin are monomeric at neutral pH and confer solubility to spidroins, whereas at lower pH, they dimerize to interconnect spidroins in a fiber. This dimerization is known to result from modulation of electrostatic interactions by protonation of well-conserved glutamates, although it is undetermined if this mechanism applies to other spidroin types as well. Here, we determine the solution and crystal structures of the flagelliform spidroin NT, which shares only 35% identity with MaSp NT, and investigate the mechanisms of its dimerization. We show that flagelliform spidroin NT is structurally similar to MaSp NT and that the electrostatic intermolecular interaction between Asp 40 and Lys 65 residues is conserved. However, the protonation events involve a different set of residues than in MaSp, indicating that an overall mechanism of pH-dependent dimerization is conserved but can be mediated by different pathways in different silk types.
- Published
- 2022
31. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference
- Author
-
Renate B Schnabel, Elena Andreassi Marinelli, Elena Arbelo, Giuseppe Boriani, Serge Boveda, Claire M Buckley, A John Camm, Barbara Casadei, Winnie Chua, Nikolaos Dagres, Mirko de Melis, Lien Desteghe, Søren Zöga Diederichsen, David Duncker, Lars Eckardt, Christoph Eisert, Daniel Engler, Larissa Fabritz, Ben Freedman, Ludovic Gillet, Andreas Goette, Eduard Guasch, Jesper Hastrup Svendsen, Stéphane N Hatem, Karl Georg Haeusler, Jeff S Healey, Hein Heidbuchel, Gerhard Hindricks, F D Richard Hobbs, Thomas Hübner, Dipak Kotecha, Michael Krekler, Christophe Leclercq, Thorsten Lewalter, Honghuang Lin, Dominik Linz, Gregory Y H Lip, Maja Lisa Løchen, Wim Lucassen, Katarzyna Malaczynska-Rajpold, Steffen Massberg, Jose L Merino, Ralf Meyer, Lluıs Mont, Michael C Myers, Lis Neubeck, Teemu Niiranen, Michael Oeff, Jonas Oldgren, Tatjana S Potpara, George Psaroudakis, Helmut Pürerfellner, Ursula Ravens, Michiel Rienstra, Lena Rivard, Daniel Scherr, Ulrich Schotten, Dipen Shah, Moritz F Sinner, Rüdiger Smolnik, Gerhard Steinbeck, Daniel Steven, Emma Svennberg, Dierk Thomas, Mellanie True Hills, Isabelle C van Gelder, Burcu Vardar, Elena Palà, Reza Wakili, Karl Wegscheider, Mattias Wieloch, Stephan Willems, Henning Witt, André Ziegler, Matthias Daniel Zink, Paulus Kirchhof, General practice, ACS - Heart failure & arrhythmias, APH - Personalized Medicine, APH - Quality of Care, Schnabel, Renate B/0000-0001-7170-9509, Rienstra, Michiel/0000-0002-2581-070X, Pala, Elena/0000-0002-1074-990X, Schnabel, Renate B., Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M., Camm, A. John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, DESTEGHE, Lien, Diederichsen, Soren Zoga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stephane N., Haeusler, Karl Georg, Healey, Jeff S., HEIDBUCHEL, Hein, Hindricks, Gerhard, Hobbs, F. D. Richard, Huebner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y. H., Lochen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L., Meyer , Ralf, Mont, Lluis, Myers, Michael C., Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S., Psaroudakis, George, Purerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah , Dipen, Sinner, Moritz F., Smolnik, Rudiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, Hills, Mellanie True, van Gelder, Isabelle C., Vardar, Burcu, Pala, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems , Stephan, Witt, Henning, Ziegler, Andre, Zink, Matthias Daniel, Kirchhof, Paulus, Cardiologie, MUMC+: MA Med Staf Spec Cardiologie (9), and RS: Carim - H08 Experimental atrial fibrillation
- Subjects
Artificial intelligence ,Technology ,Consensus ,Cost ,Medizin ,Heart failure ,Outcomes ,Guidelines ,EHRA/HRS/APHRS/SOLAECE EXPERT CONSENSUS ,Anticoagulation ,Cognition ,QUALITY-OF-LIFE ,Physiology (medical) ,MAGNETIC-RESONANCE ,Humans ,PULMONARY VEIN ISOLATION ,CARDIOVASCULAR EVENTS ,Stroke/prevention & control ,AFNET ,Atrial cardiomyopathy ,Atrial fibrillation ,Bleeding ,Catheter ablation ,Cognitive function ,Consensus statement ,Dementia ,EHRA ,Integrated care ,Quality of care ,Research ,Research priorities ,Rhythm management ,Screening ,Stroke ,ORAL ANTICOAGULANTS ,CARDIOMYOPATHIES DEFINITION ,RISK PREDICTION ,Early Diagnosis ,Human medicine ,Cardiology and Cardiovascular Medicine ,FOLLOW-UP ,Atrial Fibrillation/complications - Abstract
Europace : the European journal of pacing, arrhythmias and cardiac electrophysiology euac062 (2022). doi:10.1093/europace/euac062, Published by Oxford Univ. Press, Oxford
- Published
- 2022
- Full Text
- View/download PDF
32. Searching for atrial fibrillation: looking harder, looking longer, and in increasingly sophisticated ways. An EHRA position paper'
- Author
-
Zbigniew Kalarus, Georges H Mairesse, Adam Sokal, Giuseppe Boriani, Beata Średniawa, Ruben Casado-Arroyo, Rolf Wachter, Gerrit Frommeyer, Vassil Traykov, Nikolaos Dagres, Gregory Y H Lip, Lucas Boersma, Petr Peichl, Dobromir Dobrev, Alan Bulava, Carina Blomström-Lundqvist, Natasja M S de Groot, Renate Schnabel, Frank Heinzel, Isabelle C Van Gelder, Corrado Carbuccichio, Dipen Shah, Lars Eckardt, Cardiovascular Centre (CVC), and Cardiology
- Subjects
AF populations at risk ,AF screening ,AF screening devices ,Asymptomatic atrial fibrillation ,Atrial fibrillation ,Patient’s benefits of AF screening ,Medizin ,Stroke ,Patient's benefits of AF screening ,Physiology (medical) ,Atrial Fibrillation/diagnosis ,Humans ,Position Paper ,Cardiology and Cardiovascular Medicine - Abstract
The current AF definition requires recording in classical ECG or Holter ECG at least a 30-s episode of AF. According to the current definition, the presence of frequent shorter episodes of fast atrial arrhythmia or episodes of arrhythmia identified with widely used screening tools requires subsequent steps to establish a definite diagnosis of AF. The use of different clinical risk scores can help to refine target populations better. Due to the unpredictable and highly variable nature of AF episodes, a monitoring time lasting 2 weeks or longer is preferable to maximize the possibility of identifying subjects with AF. Several capabilities are currently available for AF search/screening, including devices based on plethysmographic pulse assessment, belts and vests for long-term ECG monitoring, modern Holter capabilities, and ILRs. Decision-making regarding using particular of them should depend on proof of efficacy based on published data, patient characteristics, and purpose of monitoring (screening/search). Additionally, all subjects with CIED with the possibility of atrial sensing should be carefully evaluated to identify AHREs. In large-scale screening projects, ML and AI could provide the appropriate interpretation of large databases containing the results of a giant number of participants. From the patient perspective, participation in screening has positive but also negative aspects. Therefore, each patient should be able to accept or refuse to participate in a screening programme, being fully aware of the potential benefits or hurdles of the screening. As the first step of shared decision-making, identifying a patient’s values, goals, and preferences is mandatory.
- Published
- 2022
- Full Text
- View/download PDF
33. MAKING THE CASE FOR A DEDICATED CYBER LAW FOR INDIA: A PRIVATE INTERNATIONAL LAW PERSPECTIVE
- Author
-
Dipen Shah
- Published
- 2022
- Full Text
- View/download PDF
34. Are intracardiac defibrillator electrogram recordings of triggering ectopy the key to successful ablation of polymorphic ventricular tachycardia/ventricular fibrillation?
- Author
-
Dipen Shah
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Ablation ,Ventricular tachycardia ,medicine.disease ,Electrocardiography ,Physiology (medical) ,Internal medicine ,Ventricular Fibrillation ,Ventricular fibrillation ,Catheter Ablation ,Tachycardia, Ventricular ,medicine ,Cardiology ,Humans ,Electrophysiologic Techniques, Cardiac ,Cardiology and Cardiovascular Medicine ,business ,Defibrillators - Published
- 2022
- Full Text
- View/download PDF
35. Critical appraisal of technologies to assess electrical activity during atrial fibrillation: a position paper from the European Heart Rhythm Association and European Society of Cardiology Working Group on eCardiology in collaboration with the Heart Rhythm Society, Asia Pacific Heart Rhythm Society, Latin American Heart Rhythm Society and Computing in Cardiology
- Author
-
Natasja M S, de Groot, Dipen, Shah, Patrick M, Boyle, Elad, Anter, Gari D, Clifford, Isabel, Deisenhofer, Thomas, Deneke, Pascal, van Dessel, Olaf, Doessel, Polychronis, Dilaveris, Frank R, Heinzel, Suraj, Kapa, Pier D, Lambiase, Joost, Lumens, Pyotr G, Platonov, Tachapong, Ngarmukos, Juan Pablo, Martinez, Alejandro Olaya, Sanchez, Yoshihide, Takahashi, Bruno P, Valdigem, Alle-Jan, van der Veen, Kevin, Vernooy, Ruben, Casado-Arroyo, Tom, De Potter, Borislav, Dinov, Jedrzej, Kosiuk, Dominik, Linz, Lis, Neubeck, Emma, Svennberg, Young-Hoon, Kim, Elaine, Wan, Nestor, Lopez-Cabanillas, Emanuela T, Locati, Peter, Macfarlane, Biomedische Technologie, RS: Carim - H07 Cardiovascular System Dynamics, Cardiologie, MUMC+: MA Med Staf Spec Cardiologie (9), RS: Carim - H06 Electro mechanics, RS: Carim - H01 Clinical atrial fibrillation, RS: Carim - H08 Experimental atrial fibrillation, and Cardiology
- Subjects
Signal processing ,CATHETER ABLATION ,FRACTIONATED ELECTROGRAMS ,ACTIVATION TIME ,Body Surface Potential Mapping ,FOCAL IMPULSE ,Cardiology ,DOMINANT FREQUENCY SITES ,BIPOLAR VOLTAGE ,Latin America ,Mapping ,Physiology (medical) ,Cardiac implantable electronic devices ,Machine learning ,Atrial Fibrillation ,CONVENTIONAL ABLATION ,MAPPING SYSTEM ,Signal recording ,EHRA position paper ,Humans ,IMPLANTABLE CARDIAC MONITOR ,Heart Atria ,Cardiology and Cardiovascular Medicine ,PULMONARY VEIN ISOLATION - Abstract
We aim to provide a critical appraisal of basic concepts underlying signal recording and processing technologies applied for (i) atrial fibrillation (AF) mapping to unravel AF mechanisms and/or identifying target sites for AF therapy and (ii) AF detection, to optimize usage of technologies, stimulate research aimed at closing knowledge gaps, and developing ideal AF recording and processing technologies. Recording and processing techniques for assessment of electrical activity during AF essential for diagnosis and guiding ablative therapy including body surface electrocardiograms (ECG) and endo- or epicardial electrograms (EGM) are evaluated. Discussion of (i) differences in uni-, bi-, and multi-polar (omnipolar/Laplacian) recording modes, (ii) impact of recording technologies on EGM morphology, (iii) global or local mapping using various types of EGM involving signal processing techniques including isochronal-, voltage- fractionation-, dipole density-, and rotor mapping, enabling derivation of parameters like atrial rate, entropy, conduction velocity/direction, (iv) value of epicardial and optical mapping, (v) AF detection by cardiac implantable electronic devices containing various detection algorithms applicable to stored EGMs, (vi) contribution of machine learning (ML) to further improvement of signals processing technologies. Recording and processing of EGM (or ECG) are the cornerstones of (body surface) mapping of AF. Currently available AF recording and processing technologies are mainly restricted to specific applications or have technological limitations. Improvements in AF mapping by obtaining highest fidelity source signals (e.g. catheter–electrode combinations) for signal processing (e.g. filtering, digitization, and noise elimination) is of utmost importance. Novel acquisition instruments (multi-polar catheters combined with improved physical modelling and ML techniques) will enable enhanced and automated interpretation of EGM recordings in the near future.
- Published
- 2021
36. High-resolution parahisian mapping and ablation using microelectrode embedded ablation catheters
- Author
-
Benjamin Berte, Gabi Hilfiker, Saagar Mahida, Jean-Yves Wielandts, Alexandre Almorad, Sebastien Knecht, Dipen Shah, Johan Vijgen, Mattias Duytschaever, and Richard Kobza
- Subjects
Electrocardiography ,Catheters ,Physiology (medical) ,Atrioventricular Node ,Catheter Ablation ,Humans ,Tachycardia, Atrioventricular Nodal Reentry ,Prospective Studies ,Cardiology and Cardiovascular Medicine ,Atrioventricular Block ,Microelectrodes - Abstract
Accurate mapping of the compact atrioventricular (AV) node is critical during ablation of a range of arrhythmias.The purpose of this multicenter prospective study was to test the hypothesis that microelectrode (ME)-embedded catheters more accurately define the near-field compact AV node compared to conventional catheters.For the mapping phase, detailed AV junction maps were created in 47 patients using an ME-embedded catheter. His electrograms (EGMs) detected by conventional electrodes (HisIn the mapping phase, 7.0 ± 5.4 HisME more accurately defines the region of the compact node, and ablation in this region is associated with a high risk for AV block. ME-based mapping has the potential to significantly enhance ablation safety and efficacy.
- Published
- 2021
37. Evolution of post–pulmonary vein isolation atrial fibrillation inducibility at redo ablation: Electrophysiological evidence of extra–pulmonary vein substrate progression
- Author
-
Mehdi Namdar, Nicolas Johner, Georgios Giannakopoulos, Dipen Shah, and Anne Girardet
- Subjects
Male ,medicine.medical_specialty ,Right atrial enlargement ,medicine.medical_treatment ,Catheter ablation ,Outcomes ,030204 cardiovascular system & hematology ,Pulmonary vein isolation ,Pulmonary vein ,03 medical and health sciences ,0302 clinical medicine ,Heart Conduction System ,Recurrence ,Physiology (medical) ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Heart Atria ,cardiovascular diseases ,030212 general & internal medicine ,Vein ,Atypical atrial flutter ,Atrial tachycardia ,Coronary sinus ,Retrospective Studies ,ddc:616 ,Inducibility ,ddc:618 ,business.industry ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Ablation ,Treatment Outcome ,medicine.anatomical_structure ,Pulmonary Veins ,Catheter Ablation ,Disease Progression ,cardiovascular system ,Cardiology ,Female ,medicine.symptom ,Electrophysiologic Techniques, Cardiac ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background The electrophysiological substrate underlying atrial fibrillation (AF) progression remains difficult to identify. Objective The goals of this study were to study the evolution of post–pulmonary vein isolation (PVI) AF inducibility (AFI) after AF ablation and to compare patients with organized atrial tachycardia recurrence (OATr) versus those with paroxysmal or persistent AF recurrence. Methods We studied 99 patients who underwent de novo AF ablation (p1) and redo ablation (p2) for AF recurrence (AFr) or OATr. Stepwise AF ablation was performed at p1 and p2: (1) PVI, (2) coronary sinus defragmentation, and (3) left atrial (LA) defragmentation. Burst pacing followed each step, with AFI defined as sustained AF >5 minutes, triggering the next step. Patients with OATr underwent OAT ablation and inducibility testing post-redo PVI. Inducibility progression (IP) was defined as AFI at further steps of p2 compared to p1. Results Among patients with AFr, 34 of 72 patients (47%) exhibited post-PVI IP vs 2 of 27 (7.4%) patients with OATr (P = .0002). Stratification for persistent AF/paroxysmal AF/OATr showed a consistent association between recurrence phenotype and IP. Pulmonary vein (PV) reconnection incidence was 90%, without association with recurrence type or IP. LA volume was larger in patients with IP than in those without IP (86.7 ± 25.3 mL vs 72.0 ± 28.9 mL; P = .001). Right atrial dimensions increased between p1 and p2 in patients with IP vs no IP and in patients with AFr vs OATr. Conclusion Patients with AFr after first ablation exhibit IP more frequently at redo ablation than do patients with OATr. IP correlates with more advanced AFr type, larger LA volumes, and progressive right atrial enlargement. PV reconnection is not associated with AFr. Changes in post-PVI AFI may accurately indicate progression of extra-PV AF-maintaining substrate.
- Published
- 2019
- Full Text
- View/download PDF
38. A dynamic model for vibration studies of dry and lubricated deep groove ball bearings considering local defects on races
- Author
-
V.N. Patel and Dipen Shah
- Subjects
Materials science ,Ball bearing ,Applied Mathematics ,020208 electrical & electronic engineering ,010401 analytical chemistry ,Rotational speed ,02 engineering and technology ,Mechanics ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,law.invention ,Vibration ,Contact mechanics ,law ,Deflection (engineering) ,0202 electrical engineering, electronic engineering, information engineering ,Lubrication ,Ball (bearing) ,Electrical and Electronic Engineering ,Lubricant ,Instrumentation - Abstract
A dynamic model has been developed to predict vibration generated by healthy and defective deep groove ball bearing. The masses of shaft, raceways, ball and housing have been considered in the present model. Moreover, stiffness and damping due to non-linear Hertzian contact and lubricant film have been included in the dynamic model. The additional deflection of rolling elements in presence of local defect has been considered during simulation of defect in dynamic model. The derived equations of motions have been solved analytically using fourth order Runge-Kutta method in MATLAB software. The vibrations generated by dry and lubricated contact bearings having local defects on their races have been studied theoretically and experimentally. It has been observed that the vibration amplitude of characteristic defect frequency is affected by presence of lubricant, shaft rotational speed, radial load, defect location and its size. Good relation between theoretical and experimental results proves the effectiveness of the present model. The authors believe that the present dynamic model can be used with confidence to predict the amplitude and frequency generated by healthy and defective bearings.
- Published
- 2019
- Full Text
- View/download PDF
39. Silent cerebral lesions and cognitive function after pulmonary vein isolation with an irrigated gold‐tip catheter: REDUCE‐TE Pilot study
- Author
-
Josef Kautzner, Béla Merkely, Dipen Shah, Alan Bulava, Boris Schmidt, Felix Bourier, Georg Nölker, Beate Wenzel, Julian K.R. Chun, Thorsten Lewalter, Gábor Széplaki, Malte Kuniss, Norbert Klein, Vincent van Driel, and Muchtiar Khan
- Subjects
Male ,Time Factors ,medicine.medical_treatment ,Action Potentials ,Pilot Projects ,030204 cardiovascular system & hematology ,Cardiac Catheters ,0302 clinical medicine ,Cognition ,Heart Rate ,Germany ,Atrial Fibrillation ,030212 general & internal medicine ,Stroke ,pulmonary vein isolation ,Univariate analysis ,Incidence ,Atrial fibrillation ,Equipment Design ,Middle Aged ,Ablation ,Mental Status and Dementia Tests ,irrigated catheter ,Catheter ,Treatment Outcome ,Intracranial Embolism ,Pulmonary Veins ,Cardiology ,Catheter Ablation ,gold‐tip catheter ,Original Article ,Female ,Tamponade ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,silent cerebral embolism ,Catheter ablation ,Asymptomatic ,ablation ,03 medical and health sciences ,Clinical ,Postoperative Cognitive Complications ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,Therapeutic Irrigation ,cognitive function ,Aged ,business.industry ,Original Articles ,medicine.disease ,Diffusion Magnetic Resonance Imaging ,Asymptomatic Diseases ,Gold ,business - Abstract
Introduction Stroke is one of the most feared complications during catheter ablation of atrial fibrillation (AF). While symptomatic thromboembolic events are rare, magnetic resonance imaging (MRI) may identify asymptomatic (ie, silent) cerebral lesions (SCLs) following pulmonary vein isolation (PVI) procedures. Methods and Results The REDUCE‐TE Pilot was a prospective multicenter, single‐arm observational study investigating the incidence of SCL in patients with symptomatic paroxysmal AF undergoing PVI with a novel gold‐tip, externally irrigated ablation catheter. After ablation, cerebral diffusion‐weighted MRI and a postablation follow‐up were performed at 1 to 3 days after the ablation procedure. A neurocognitive test was done before and after ablation. The primary study endpoint was the occurrence of one or more new SCLs. Secondary study endpoints included neurocognitive status, procedural success rate, and periprocedural complications including symptomatic thromboembolic events. A total of 104 patients were enrolled (69% male, mean age: 61.5 ± 9.7 years, mean CHA2DS 2‐VASc score: 1.7 ± 1.2). Postprocedural MRI examination was performed in 97 patients, and in nine of them (9.3%; 95% CI: 4.3‐16.9%) a total of 11 SCLs were detected. Univariate analyses did not reveal any significant predictor for new SCLs. Nonsignificant trends were observed for low activated clotting time during ablation and for international normalized ratio value outside the range of 2 to 3 at ablation. There was no evidence of significant deterioration of neurocognitive function after PVI. In four patients, a pericardial tamponade was noted but all patients fully recovered during follow‐up. Conclusions Ablation of AF using a novel gold‐tip, externally irrigated ablation catheter, resulted in SCLs in approximately one out of 10 patients without a measurable effect on neurocognitive function.
- Published
- 2019
40. Individualised Approaches for Catheter Ablation of AF: Patient Selection and Procedural Endpoints
- Author
-
Mehdi Namdar, Dipen Shah, and Nicolas Johner
- Subjects
termination ,medicine.medical_specialty ,medicine.medical_treatment ,Electrophysiology and Ablation ,predictor ,Catheter ablation ,Pulmonary vein ,Physiology (medical) ,catheter ablation ,Medicine ,Diseases of the circulatory (Cardiovascular) system ,Intensive care medicine ,pulmonary vein isolation ,High rate ,business.industry ,non-inducibility ,endpoint ,individualised ,Atrial fibrillation ,AF ,Ablation ,medicine.disease ,Treatment efficacy ,Clinical Practice ,RC666-701 ,outcome ,Cardiology and Cardiovascular Medicine ,business ,Af ablation - Abstract
Pulmonary vein isolation (PVI) is the cornerstone of AF ablation, but studies have reported improved efficacy with high rates of repeat procedures. Because of the large interindividual variability in the underlying electrical and anatomical substrate, achieving optimal outcomes requires an individualised approach. This includes optimal candidate selection as well as defined ablation strategies with objective procedure endpoints beyond PVI. Candidate selection is traditionally based on coarse and sometimes arbitrary clinical stratification such as AF type, but finer predictors of treatment efficacy including biomarkers, advanced imaging and electrocardiographic parameters have shown promise. Numerous ancillary ablation strategies beyond PVI have been investigated, but the absence of a clear mechanistic and evidence-based endpoint, unlike in other arrhythmias, has remained a universal limitation. Potential endpoints include functional ones such as AF termination or non-inducibility and substrate-based endpoints such as isolation of low-voltage areas. This review summarises the relevant literature and proposes guidance for clinical practice and future research.
- Published
- 2019
41. Theoretical and experimental vibration studies of lubricated deep groove ball bearings having surface waviness on its races
- Author
-
Dipen Shah and V.N. Patel
- Subjects
Materials science ,Bearing (mechanical) ,Waviness ,Applied Mathematics ,Rotational speed ,02 engineering and technology ,Mechanics ,Condensed Matter Physics ,01 natural sciences ,law.invention ,Physics::Fluid Dynamics ,Vibration ,020303 mechanical engineering & transports ,Contact mechanics ,0203 mechanical engineering ,law ,0103 physical sciences ,Lubrication ,Electrical and Electronic Engineering ,Lubricant ,010301 acoustics ,Instrumentation ,Groove (music) - Abstract
A dynamic model has been presented to study vibrations of deep groove ball bearings having waviness on surface of bearing races. Masses of shaft, races, balls and housing have been considered in modelling. Stiffness and damping due to non-linear Hertzian contact and lubricant film have been incorporated in dynamic model. The coupled solution of governing equations of motions is obtained using Runge Kutta method. The vibrations velocity spectra of bearing housing computed through dynamic model have been validated with experimental results, which were generated using healthy and defective deep groove ball bearings. The effect of governing parameters like radial load, shaft rotational speed, waviness order, waviness amplitude on amplitude of waviness defect frequency have been investigated broadly using both theoretical and experimental results. Severe vibration amplitudes have been observed in presence of waviness order equal to number of balls. Good correlations between theoretical and experimental results have been observed. The present study would give researchers new insights into dynamic behaviour of shaft bearing system.
- Published
- 2018
- Full Text
- View/download PDF
42. Factors predicting adverse cardiovascular outcomes in patients with atrial fibrillation and heart failure with preserved ejection fraction
- Author
-
Sanjeev Saksena, Dhanunjay Lakkireddy, Andrea Natale, April Slee, Dipen Shah, Thorsten Lewalter, and Luigi Di Biase
- Subjects
medicine.medical_specialty ,Ejection fraction ,business.industry ,Atrial fibrillation ,medicine.disease ,Sudden death ,Sudden cardiac death ,Blood pressure ,Physiology (medical) ,Internal medicine ,Heart failure ,Heart rate ,Cardiology ,Medicine ,Cardiology and Cardiovascular Medicine ,Heart failure with preserved ejection fraction ,business - Abstract
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Electrophysiology Research Foundation Introduction Atrial fibrillation (AF) is known to impact cardiovascular(CV) mortality in heart failure (HF) patients (pts) with preserved ejection fraction (pEF) but its exact causes are unknown. Methods We analyzed demographic, clinical, ECG and AF presentation as predictors of CV mortality, sudden death( SCD) and pump failure death(PFD) in HFpEF pts in the TOPCAT AMERICAS trial. We analyzed two AF presentations 1. Pts in sinus rhythm (SR, n = 1319) compared to AF on ECG (n = 446) at entry or 2. Pts with no AF event by history or ECG ( n = 1007 ) to those with any AF event (n = 760 ). Results (Table): 5 year (yr) CV mortality was higher in pts with AF on ECG (30%) than SR (18%, p = 0.014) but 5 yr SCD was (10% in AF on ECG & 7% in any AF) & comparable to SR (7% & 9% respectively, p = ns). 5 yr PFD was higher in AF on ECG (13%) than SR (5%, p = 0.007) Conclusions : 1. CV death risk in HFpEF pts increased with AF on ECG.. 2. SCD was not more frequent with both AF presentations 3. PFD in HFpEF increased with age, ECG recorded AF & elevated heart rate. 4. The recording of AF on ECG was more strongly associated with CV death & PFD, possibly due to greater AF burden . Predictors of adverse outcomes in HFpEF AF on ECG* Any AF* Endpoint Covariate HR (95% CI) p-value HR (95% CI) p-value Time to cardiovascular death Atrial Fibrillation* 1.44 (1.08, 1.92) 0.014 1.15 (0.87, 1.51) 0.338 Age (years) 1.03 (1.02, 1.05)
- Published
- 2021
- Full Text
- View/download PDF
43. Impact of contact force sensing technology on outcome of catheter ablation of idiopathic pre-mature ventricular contractions originating from the outflow tracts
- Author
-
Tobias Reichlin, Richard Kobza, Jens Seiler, Christian Schlatzer, Peter Ammann, Samuel H. Baldinger, Haran Burri, Etienne Pruvot, Laurence Bisch, Christian Sticherling, Sven Knecht, Michael Kühne, Giulio Conte, Dipen Shah, Benjamin Berte, Stefan Osswald, Angelo Auricchio, David Altmann, Andreas Mueller, Babken Asatryan, Mehdi Namdar, Laurent Roten, Laurent M. Haegeli, University of Zurich, and Clinical sciences
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Heart Ventricles ,Catheter Ablation/adverse effects ,Catheter ablation ,610 Medicine & health ,11171 Cardiocentro Ticino ,Ventricular Premature Complexes/diagnosis ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,Complication rate ,Retrospective Studies ,business.industry ,Atrial fibrillation ,Cardiac Ablation ,Middle Aged ,medicine.disease ,Ablation ,Ventricular Premature Complexes ,Treatment Outcome ,Mapping system ,technology ,Cardiology ,Catheter Ablation ,Female ,business ,Cardiology and Cardiovascular Medicine ,Holter ecg - Abstract
Aims Catheter ablation of frequent idiopathic pre-mature ventricular contractions (PVC) is increasingly performed. While potential benefits of contact force (CF)-sensing technology for atrial fibrillation ablation have been assessed in several studies, the impact of CF-sensing on ventricular arrhythmia ablation remains unknown. This study aimed to compare outcomes of idiopathic outflow tract PVC ablation when using standard ablation catheters as opposed to CF-sensing catheters. Methods and results In a retrospective multi-centre study, unselected patients undergoing catheter ablation of idiopathic outflow tract PVCs between 2013 and 2016 were enrolled. All procedures were performed using irrigated-tip ablation catheters and a 3D electro-anatomical mapping system. Sustained ablation success was defined as a ≥80% reduction of pre-procedural PVC burden determined by 24 h Holter ECG during follow-up. Overall, 218 patients were enrolled (median age 52 years, 51% males). Baseline and procedural data were similar in the standard ablation (24%) and the CF-sensing group (76%). Overall, the median PVC burden decreased from 21% (IQR 10–30%) before ablation to 0.2% (IQR 0–3.0%) after a median follow-up of 2.3 months (IQR 1.4–3.9 months). The rates of both acute (91% vs. 91%, P = 0.94) and sustained success (79% vs. 74%, P = 0.44) were similar in the standard ablation and the CF-sensing groups. No differences were observed in subgroups according to arrhythmia origin from the RVOT (65%) or LVOT (35%). Complications were rare (1.8%) and evenly distributed between the two groups. Conclusion The use of CF-sensing technology is not associated with increased success rate nor decreased complication rate in idiopathic outflow tract PVC ablation.
- Published
- 2021
- Full Text
- View/download PDF
44. B-PO04-186 ATRIAL FIBRILLATION IS ASSOCIATED WITH WORSENING OF HEART FAILURE (HF) AND CARDIOVASCULAR HOSPITALIZATIONS (CVH) IN HF WITH PRESERVED EJECTION FRACTION (HFPEF) IN MINORITIES AND SPECIFIC CO-MORBIDITIES
- Author
-
Rangadham Nagarakanti, Dhanunjaya Lakkireddy, Sanjeev Saksena, Andrea Natale, Pasquale Santangeli, Thorsten Lewalter, Luigi Di Biase, Dipen Shah, and April Slee
- Subjects
medicine.medical_specialty ,Ejection fraction ,business.industry ,Physiology (medical) ,Heart failure ,Internal medicine ,medicine ,Cardiology ,Co morbidity ,Atrial fibrillation ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business - Published
- 2021
- Full Text
- View/download PDF
45. Abstract 15198: Predictors of Adverse Cardiovascular Outcomes in Patients With Atrial Fibrillation and Heart Failure With Preserved Systolic Function: A Topcat Americas Post Hoc Analysis
- Author
-
Dhanunjaya Lakkireddy, Andrea Natale, Dipen Shah, April Slee, Luigi Di Biase, Thorsten Lewalter, and Sanjeev Saksena
- Subjects
medicine.medical_specialty ,business.industry ,Atrial fibrillation ,Systolic function ,medicine.disease ,Sudden death ,Clinical trial ,Physiology (medical) ,Internal medicine ,Heart failure ,Post-hoc analysis ,Cardiology ,Medicine ,In patient ,Cardiology and Cardiovascular Medicine ,business ,Cardiovascular outcomes - Abstract
Introduction: Presence of atrial fibrillation (AF) is known to increase mortality and impact cardiovascular(CV) outcomes in heart failure (HF) patients (pts) with preserved systolic function (pEF) but its causes are unknown Hypothesis: We hypothesized that AF presentation & clinical factors impact mode of death & CV outcomes of HFpEF pts in the TOPCAT AMERICAS trial. Methods: We analyzed demographic, clinical, ECG and AF presentation as predictors of CV mortality, sudden death( SCD) and pump failure death(PFD). We examined two AF presentations 1. Pts in sinus rhythm (SR, n=1319) compared to pts in AF (n=446) on ECG at study entry or 2. Pts with no AF event by history or ECG ( n=1007 ) compared to those with any AF event (n=760 ) during a mean follow up period of 2.9 years(yrs). Results: AF pts when compared to the rest of the study population were more likely to be older, male, Caucasian origin, have more alcohol use, diabetes, percutaneous coronary interventions. 5 yr CV mortality was higher in pts with AF on ECG (30%) than those in sinus rhythm (18%, p=0.014) but 5 yr SCD was lower (10% in AF on ECG & 7% in any AF) & comparable to SR (7% & 9% respectively, p=ns). 5 yr PFD was higher (13%) than SR (5%, p=0.007. )Table shows Cox proportional hazards analysis of covariates associated with time to CV death, time to SCD & time to PFD adjusted for baseline imbalances. Conclusions:: 1. CV death risk in HFpEF pts increased with age, in minorities, smokers, diabetics, with lower systolic bp, elevated heart rate & AF on ECG.. 2. SCD was more frequent in males, African Americans & diabetics but was low in both AF & SR, perhaps due to a dominant atrial & limited ventricular arrhythmogenic substrate in HFpEF. 3. PFD in HFpEF increased with age, ECG recorded AF & elevated heart rate.This may reflect importance of atrioventricular synchrony in HFpEF. 4. The recording of AF on ECG at study entry was more strongly associated with CV death & PFD, possibly due to greater AF burden in this group compared to those with any AF even..
- Published
- 2020
- Full Text
- View/download PDF
46. Significance of post-pacing intervals shorter than tachycardia cycle length for successful catheter ablation of atypical flutter
- Author
-
Nicolas Johner, Mehdi Namdar, Pietro Bernardo Dall’Aglio, and Dipen Shah
- Subjects
Tachycardia ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Cardiac Pacing, Artificial ,Catheter ablation ,Odds ratio ,Cardiac Ablation ,Ablation ,Confidence interval ,Electrocardiography ,Atrial Flutter ,Physiology (medical) ,Internal medicine ,Cardiology ,medicine ,Catheter Ablation ,Flutter ,Humans ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Entrainment (chronobiology) - Abstract
Aims During entrainment mapping of macro-reentrant tachycardias, the time difference (dPPI) between post-pacing interval (PPI) and tachycardia cycle length (TCL) is thought to be a function of the distance of the pacing site to the re-entry circuit and dPPI Methods and results A total of 177 ablation procedures were investigated. Surface electrocardiograms (ECGs) were evaluated and combined activation and entrainment mapping were performed to choose ablation sites. Each entrainment sequence immediately preceding static radiofrequency delivery at the same site was analysed. A total of 545 entrainment sequences were analysed. dPPI Conclusion When combined with activation mapping, a negative dPPI is a more effective parameter for identifying a target for successful ablation compared to a dPPI = 0–30 ms. Its occurrence is associated with a critical small narrow slow-conducting isthmus at the target site.
- Published
- 2020
47. Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation
- Author
-
Steffen Blum, Stefanie Aeschbacher, Pascal Meyre, Michael Kühne, Nicolas Rodondi, Jürg H. Beer, Peter Ammann, Giorgio Moschovitis, Leo H. Bonati, Manuel R. Blum, Peter Kastner, Fiona Baguley, Christian Sticherling, Stefan Osswald, David Conen, Chloé Auberson, Leo Bonati, Selinda Ceylan, Simone Doerpfeld, Ceylan Eken, Marc Girod, Peter Hämmerle, Philipp Krisai, Christine Meyer-Zürn, Andreas U. Monsch, Christian Müller, Anne Springer, Thomas Szucs, Gian Voellmin, Leon Zwimpfer, Drahomir Aujesky, Urs Fischer, Juerg Fuhrer, Laurent Roten, Simon Jung, Heinrich Mattle, Luise Adam, Carole Elodie Aubert, Martin Feller, Axel Loewe, Elisavet Moutzouri, Claudio Schneider, Tanja Flückiger, Cindy Groen, Lukas Ehrsam, Sven Hellrigl, Alexandra Nuoffer, Damiana Rakovic, Nathalie Schwab, Rylana Wenger, Christopher Beynon, Roger Dillier, Michèle Deubelbeiss, Franz Eberli, Christine Franzini, Isabel Juchli, Claudia Liedtke, Jacqueline Nadler, Thayze Obst, Jasmin Roth, Fiona Schlomowitsch, Xiaoye Schneider, Katrin Studerus, Noreen Tynan, Dominik Weishaupt, Andreas Müller, Simone Fontana, Silke Kuest, Karin Scheuch, Denise Hischier, Nicole Bonetti, Alexandra Grau, Jonas Villinger, Eva Laube, Philipp Baumgartner, Mark Filipovic, Marcel Frick, Giulia Montrasio, Stefanie Leuenberger, Franziska Rutz, Jürg-Hans Beer, Angelo Auricchio, Adriana Anesini, Cristina Camporini, Giulio Conte, Maria Luce Caputo, Francois Regoli, Tiziano Moccetti, Roman Brenner, David Altmann, Michaela Gemperle, Mathieu Firmann, Sandrine Foucras, Martine Rime, Daniel Hayoz, Benjamin Berte, Virgina Justi, Frauke Kellner-Weldon, Brigitta Mehmann, Sonja Meier, Myriam Roth, Andrea Ruckli-Kaeppeli, Ian Russi, Kai Schmidt, Mabelle Young, Melanie Zbinden, Richard Kobza, Jane Frangi-Kultalahti, Anica Pin, Luisa Vicari, Georg Ehret, Hervé Gallet, Elise Guillermet, Francois Lazeyras, Karl-Olof Lovblad, Patrick Perret, Philippe Tavel, Cheryl Teres, Dipen Shah, Nathalie Lauriers, Marie Méan, Sandrine Salzmann, Jürg Schläpfer, Andrea Grêt, Jan Novak, Sandra Vitelli, Frank-Peter Stephan, Augusto Gallino, Marcello Di Valentino, Fabienne Witassek, Matthias Schwenkglenks, Jens Würfel, Anna Altermatt, Michael Amann, Petra Huber, Esther Ruberte, Tim Sinnecker, Vanessa Zuber, Michael Coslovsky, Pascal Benkert, Gilles Dutilh, Milica Markovic, Patrick Simon, Ramun Schmid, Clinical sciences, Auberson, Chloé, Bonati, Leo, Ceylan, Selinda, Doerpfeld, Simone, Eken, Ceylan, Girod, Marc, Hämmerle, Peter, Krisai, Philipp, Meyer-Zürn, Christine, Monsch, Andreas U., Müller, Christian, Springer, Anne, Szucs, Thomas, Voellmin, Gian, Zwimpfer, Leon, Aujesky, Drahomir, Fischer, Urs, Fuhrer, Juerg, Roten, Laurent, Jung, Simon, Mattle, Heinrich, Adam, Luise, Aubert, Carole Elodie, Feller, Martin, Loewe, Axel, Moutzouri, Elisavet, Schneider, Claudio, Flückiger, Tanja, Groen, Cindy, Ehrsam, Lukas, Hellrigl, Sven, Nuoffer, Alexandra, Rakovic, Damiana, Schwab, Nathalie, Wenger, Rylana, Beynon, Christopher, Dillier, Roger, Deubelbeiss, Michèle, Eberli, Franz, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Nadler, Jacqueline, Obst, Thayze, Roth, Jasmin, Schlomowitsch, Fiona, Schneider, Xiaoye, Studerus, Katrin, Tynan, Noreen, Weishaupt, Dominik, Müller, Andreas, Fontana, Simone, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Grau, Alexandra, Villinger, Jonas, Laube, Eva, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Montrasio, Giulia, Leuenberger, Stefanie, Rutz, Franziska, Auricchio, Angelo, Anesini, Adriana, Camporini, Cristina, Conte, Giulio, Caputo, Maria Luce, Regoli, Francois, Moccetti, Tiziano, Brenner, Roman, Altmann, David, Gemperle, Michaela, Firmann, Mathieu, Foucras, Sandrine, Rime, Martine, Hayoz, Daniel, Berte, Benjamin, Justi, Virgina, Kellner-Weldon, Frauke, Mehmann, Brigitta, Meier, Sonja, Roth, Myriam, Ruckli-Kaeppeli, Andrea, Russi, Ian, Schmidt, Kai, Young, Mabelle, Zbinden, Melanie, Kobza, Richard, Frangi-Kultalahti, Jane, Pin, Anica, Vicari, Luisa, Ehret, Georg Benedikt, Gallet, Hervé, Guillermet, Elise, Lazeyras, François, Lövblad, Karl-Olof, Perret, Patrick, Tavel, Philippe, Teres Castillo, Cheryl, Shah, Dipen, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Schläpfer, Jürg, Grêt, Andrea, Novak, Jan, Vitelli, Sandra, Stephan, Frank-Peter, Gallino, Augusto, Di Valentino, Marcello, Witassek, Fabienne, Schwenkglenks, Matthias, Würfel, Jens, Altermatt, Anna, Amann, Michael, Huber, Petra, Ruberte, Esther, Sinnecker, Tim, Zuber, Vanessa, Coslovsky, Michael, Benkert, Pascal, Dutilh, Gilles, Markovic, Milica, Simon, Patrick, and Schmid, Ramun
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_class ,Epidemiology ,Heart failure ,030204 cardiovascular system & hematology ,ddc:616.0757 ,03 medical and health sciences ,0302 clinical medicine ,Insulin-Like Growth Factor Binding Proteins/blood ,Physiology (medical) ,Internal medicine ,Atrial Fibrillation ,Clinical endpoint ,Natriuretic peptide ,medicine ,Heart Failure/blood ,Humans ,030212 general & internal medicine ,cardiovascular diseases ,Hospitalization/statistics & numerical data ,Aged ,Retrospective Studies ,ddc:616 ,Heart Failure ,Proportional hazards model ,business.industry ,Insulin-like growth factor-binding protein 7 ,Hazard ratio ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Prognosis ,Confidence interval ,Hospitalization ,Insulin-Like Growth Factor Binding Proteins ,Atrial Fibrillation/blood ,Cardiology ,Disease Progression ,Female ,business ,Cardiology and Cardiovascular Medicine ,Biomarkers/blood ,Biomarkers ,Cohort study ,Follow-Up Studies - Abstract
BACKGROUND: The occurrence of congestive heart failure (CHF) hospitalization among patients with atrial fibrillation (AF) is a poor prognostic marker. OBJECTIVE: The purpose of this study was to assess whether insulin-like growth factor-binding protein 7 (IGFBP-7), a marker of myocardial damage, identifies AF patients at high risk for this complication. METHODS: We analyzed 2 prospective multicenter observational cohort studies that included 3691 AF patients. Levels of IGFBP-7 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured from frozen plasma samples at baseline. The primary endpoint was hospitalization for CHF. Multivariable adjusted Cox regression analyses were constructed. RESULTS: Mean patient age was 69 ± 12 years, 1028 (28%) were female, and 879 (24%) had a history of CHF. The incidence per 1000 patient-years across increasing IGFBP-7 quartiles was 7, 10, 32, and 85. The corresponding multivariable adjusted hazard ratios (aHRs) (95% confidence interval [CI]) were 1.0, 1.05 (0.63-1.77), 2.38 (1.50-3.79), and 4.37 (2.72-7.04) (P for trend
- Published
- 2020
48. The myocardial phenotype of Fabry disease pre-hypertrophy and pre-detectable storage
- Author
-
Richard P. Steeds, Rebecca K. Hughes, Natalia Ojrzyńska, Andreas Seraphim, Anish N Bhuva, Gabriella Captur, Rebecca Kozor, Clement Lau, Kristopher D Knott, James C. Moon, Mehdi Namdar, João B Augusto, Ravi Vijapurapu, Dipen Shah, Tarekegn Geberhiwot, Derralynn Hughes, Mashael Alfarih, Nicolas Johner, Sabrina Nordin, Stefania Rosmini, Linda Lin, and Uma Ramaswami
- Subjects
Male ,Global longitudinal strain ,microvascular dysfunction ,Contrast Media ,Gadolinium ,030204 cardiovascular system & hematology ,Left ventricular hypertrophy ,Ventricular Function, Left ,Muscle hypertrophy ,0302 clinical medicine ,AcademicSubjects/MED00200 ,030212 general & internal medicine ,Prospective Studies ,ddc:616 ,medicine.diagnostic_test ,General Medicine ,Phenotype ,Microvascular dysfunction ,Cardiology ,cardiovascular system ,Female ,Hypertrophy, Left Ventricular ,Cardiology and Cardiovascular Medicine ,Perfusion ,global longitudinal strain ,medicine.medical_specialty ,Magnetic Resonance Imaging, Cine ,electrocardiogram ,03 medical and health sciences ,cardiovascular magnetic resonance ,Linear gingival erythema ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Fabry disease ,business.industry ,Myocardium ,Magnetic resonance imaging ,Blood flow ,Original Articles ,medicine.disease ,Electrocardiogram ,Editor's Choice ,Cardiovascular magnetic resonance ,business - Abstract
Aims Cardiac involvement in Fabry disease (FD) occurs prior to left ventricular hypertrophy (LVH) and is characterized by low myocardial native T1 with sphingolipid storage reflected by cardiovascular magnetic resonance (CMR) and electrocardiogram (ECG) changes. We hypothesize that a pre-storage myocardial phenotype might occur even earlier, prior to T1 lowering. Methods and results FD patients and age-, sex-, and heart rate-matched healthy controls underwent same-day ECG with advanced analysis and multiparametric CMR [cines, global longitudinal strain (GLS), T1 and T2 mapping, stress perfusion (myocardial blood flow, MBF), and late gadolinium enhancement (LGE)]. One hundred and fourteen Fabry patients (46 ± 13 years, 61% female) and 76 controls (49 ± 15 years, 50% female) were included. In pre-LVH FD (n = 72, 63%), a low T1 (n = 32/72, 44%) was associated with a constellation of ECG and functional abnormalities compared to normal T1 FD patients and controls. However, pre-LVH FD with normal T1 (n = 40/72, 56%) also had abnormalities compared to controls: reduced GLS (−18 ± 2 vs. −20 ± 2%, P Conclusion FD has a measurable myocardial phenotype pre-LVH and pre-detectable myocyte storage with microvascular dysfunction, subtly impaired GLS and altered atrial depolarization and ventricular repolarization intervals.
- Published
- 2020
49. Experimental Vibration Studies of Deep Groove Ball Bearings Having Damaged Surfaces
- Author
-
V.N. Patel, Dipen Shah, and P. H. Darji
- Subjects
0209 industrial biotechnology ,Materials science ,Bearing (mechanical) ,Waviness ,020209 energy ,Mechanical Engineering ,Acoustics ,Aerospace Engineering ,Ocean Engineering ,Vibration amplitude ,Rotational speed ,02 engineering and technology ,Industrial and Manufacturing Engineering ,law.invention ,Vibration ,020901 industrial engineering & automation ,Amplitude ,law ,0202 electrical engineering, electronic engineering, information engineering ,Lubricant ,Groove (music) - Abstract
Bearing plays vital role in dynamic characteristic of any rotating machine. Vibration study of rolling element bearings in the presence of either local defect or distributed defect have been carried out by many researchers. In the present study experimental vibration studies of bearing in the presence of local defect on one of the bearing race and waviness on another race have been carried out. Moreover, the effects of local defect width, waviness order, radial load, rotational speed, presence of lubricant on vibration amplitude in the presence of local defect and race waviness have also been analyzed. Frequency peaks at both characteristic defect frequencies, based on location and type of defect have been observed in the presence of combined defects. The local defect frequency amplitude of inner race/outer race is affected by presence of distributed defect on outer race/inner race and vice versa. However, the waviness frequency amplitude found dominant as compared to local defect frequency amplitude. This study will be helpful to practicing engineers in analyzing the complex vibrations generated by defective rolling elements bearings.
- Published
- 2018
- Full Text
- View/download PDF
50. Biomarkers and arrhythmia recurrence following radiofrequency ablation of atrial fibrillation
- Author
-
Nicolas Vuilleumier, Dipen Shah, Pierre-Frédéric Keller, Jean-Claude Tardif, Sebastian Carballo, Jérôme Stirnemann, Haran Burri, David Carballo, Hajo Müller, Stéphane Noble, Mario Talajic, and François Mach
- Subjects
Male ,Medicine (General) ,Clinical Research Reports ,Radiofrequency ablation ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Biochemistry ,law.invention ,Postoperative Complications ,0302 clinical medicine ,Recurrence ,Risk Factors ,law ,Atrial Fibrillation ,Natriuretic Peptide, Brain ,Prospective Studies ,030212 general & internal medicine ,ddc:616 ,biology ,Atrial fibrillation ,General Medicine ,Middle Aged ,Prognosis ,Survival Rate ,atrial flutter ,Atrial Fibrillation/surgery ,cardiovascular system ,Cardiology ,Catheter ablation ,Female ,medicine.symptom ,medicine.medical_specialty ,recurrence ,C-reactive protein ,C-Reactive Protein/analysis ,03 medical and health sciences ,R5-920 ,Natriuretic Peptide ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Inflammation ,Postoperative Complications/blood/diagnosis/etiology ,Fibrillation ,Radiofrequency Ablation ,business.industry ,Biochemistry (medical) ,Cardiac arrhythmia ,Cell Biology ,medicine.disease ,Peptide Fragments ,Radiofrequency Ablation/adverse effects ,Radiofrequency catheter ablation ,biology.protein ,Inflammation/blood/diagnosis/etiology ,Brain/blood ,natriuretic peptides ,Peptide Fragments/blood ,business ,Biomarkers ,Biomarkers/blood ,Atrial flutter ,Follow-Up Studies - Abstract
Objective Atrial fibrillation (AF) is the most common cardiac arrhythmia, and radiofrequency catheter ablation of AF (RCAAF) has become increasingly popular. Cardiac stress and inflammation have been associated with AF. This study was performed to determine whether the pre- or post-AF ablation levels of high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro–B-type natriuretic peptide (NT-proBNP) are predictive of AF recurrence. Methods This multicenter prospective cohort study involved patients undergoing RCAAF in Switzerland and Canada. The primary endpoint was the recurrence of AF or atrial flutter at 6 months. Results Of 202 patients, 195 completed follow-up (age, 57.5 ± 9 years; mean left ventricular ejection fraction, 62%; mean left atrial size, 19.4 cm2). Patients with AF recurrence had larger atrial surfaces and longer total RCAAF times. Both the pre-ablation hs-CRP level and 1-day post-RCAAF NT-proBNP level were significantly associated with an increased risk of recurrence. Conclusions The pre-ablation hs-CRP level and immediate post-ablation NT-proBNP level were markers for atrial arrhythmia recurrence after RCAAF. This confirms growing evidence of the role of inflammation in the pathogenesis of AF. These biomarkers appear to be promising stratification tools for selection and management of patients undergoing RCAAF.
- Published
- 2018
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.