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9 results on '"Diouloufet, Lucie"'

1. FLT3 signaling inhibition abrogates opioid tolerance and hyperalgesia while preserving analgesia

Author

Jouvenel, Antoine, Tassou, Adrien, Thouaye, Maxime, Ruel, Jérôme, Antri, Myriam, Leyris, Jean-Philippe, Giraudin, Aurore, Mallié, Sylvie, Sar, Chamroeum, Diouloufet, Lucie, Sonrier, Corinne, Daubeuf, François, Bertin, Juliette, Alves, Stacy, Ventéo, Stéphanie, Frossard, Nelly, Carroll, Patrick, Mechaly, Ilana, Rognan, Didier, Sokoloff, Pierre, Dallel, Radhouane, Delmas, Patrick, Valmier, Jean, and Rivat, Cyril

Published
2024
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2. Activation of neuronal FLT3 promotes exaggerated sensorial and emotional pain-related behaviors facilitating the transition from acute to chronic pain

Author

Tassou, Adrien, Thouaye, Maxime, Gilabert, Damien, Jouvenel, Antoine, Leyris, Jean-Philippe, Sonrier, Corinne, Diouloufet, Lucie, Mechaly, Ilana, Mallié, Sylvie, Bertin, Juliette, Chentouf, Myriam, Neiveyans, Madeline, Pugnière, Martine, Martineau, Pierre, Robert, Bruno, Capdevila, Xavier, Valmier, Jean, and Rivat, Cyril

Published
2023
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3. FLT3 signaling inhibition preserves opioid analgesia while abrogating tolerance and hyperalgesia

Author

Jouvenel, Antoine, primary, Tassou, Adrien, additional, Thouaye, Maxime, additional, Ruel, Jerome, additional, Antri, Myriam, additional, Leyris, Jean-Philippe, additional, Paquet, Aurore, additional, Mallie, Sylvie, additional, Sar, Chamroeum, additional, Diouloufet, Lucie, additional, Sonrier, Corinne, additional, Daubeuf, Francois, additional, Bertin, Juliette, additional, Alves, Stacy, additional, Venteo, Stephanie, additional, Frossard, Nelly, additional, Carroll, Patrick, additional, Mechaly, Ilana, additional, Rognan, Didier, additional, Sokoloff, Pierre, additional, Dallel, Radhouane, additional, Delmas, Patrick, additional, Valmier, Jean, additional, and Rivat, Cyril, additional

Published
2023
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4. Activation of Neuronal FLT3 Promotes Exaggerated Sensorial and Emotional Pain-Related Behaviors Facilitating the Transition from Acute to Chronic Pain

Author

tassou, adrien, primary, Thouaye, Maxime, additional, Gilabert, Damien, additional, Jouvenel, Antoine, additional, Leyris, Jean-Philippe, additional, Sonrier, Corinne, additional, Diouloufet, Lucie, additional, Méchaly, Ilana, additional, Mallié, Sylvie, additional, Chentouf, Myriam, additional, Neiveyans, Madeline, additional, Pugnière, Martine, additional, Martineau, Pierre, additional, Robert, Bruno, additional, Capdevila, Xavier, additional, Valmier, Jean, additional, and Rivat, Cyril, additional

Published
2022
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5. Activation of peripheral neuronal FLT3 promotes exaggerated sensorial and emotional pain-related behaviors facilitating the transition from acute to chronic pain

Author

Tassou, Adrien, primary, Thouaye, Maxime, additional, Gilarbert, Damien, additional, Jouvenel, Antoine, additional, Leyris, Jean-Philippe, additional, Sonrier, Corinne, additional, Diouloufet, Lucie, additional, Mechaly, Ilana, additional, Chentouf, Myriam, additional, Neiveyans, Madeline, additional, Pugniere, Martine, additional, Martineau, Pierre, additional, Robert, Bruno, additional, Capdevila, Xavier, additional, Valmier, Jean, additional, and Rivat, Cyril, additional

Published
2021
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6. Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice

Author

Rivat, Cyril, Sar, Chamroeun, Mechaly, Ilana, Leyris, Jean-Philippe, Diouloufet, Lucie, Sonrier, Corinne, Philipson, Yann, Lucas, Olivier, Mallié, Sylvie, Jouvenel, Antoine, Tassou, Adrien, Haton, Henri, Venteo, Stéphanie, Pin, Jean-Philippe, Trinquet, Eric, Charrier-Savournin, Fabienne, Mezghrani, Alexandre, Joly, Willy, Mion, Julie, Schmitt, Martine, Pattyn, Alexandre, Marmigère, Frédéric, Sokoloff, Pierre, Carroll, Patrick, Rognan, Didier, Valmier, Jean, Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Laboratoire d'Innovation Thérapeutique (LIT), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences de Montpellier (INM), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and ROGNAN, Didier

Subjects
Sensory Receptor Cells, Science, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV]Life Sciences [q-bio], Blotting, Western, Real-Time Polymerase Chain Reaction, Article, Mice, fluids and secretions, hemic and lymphatic diseases, Ganglia, Spinal, Animals, RNA, Small Interfering, lcsh:Science, Cells, Cultured, In Situ Hybridization, ComputingMilieux_MISCELLANEOUS, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Peripheral Nervous System Diseases, hemic and immune systems, Immunohistochemistry, Mice, Inbred C57BL, fms-Like Tyrosine Kinase 3, embryonic structures, Neuralgia, lcsh:Q
Abstract

Peripheral neuropathic pain (PNP) is a debilitating and intractable chronic disease, for which sensitization of somatosensory neurons present in dorsal root ganglia that project to the dorsal spinal cord is a key physiopathological process. Here, we show that hematopoietic cells present at the nerve injury site express the cytokine FL, the ligand of fms-like tyrosine kinase 3 receptor (FLT3). FLT3 activation by intra-sciatic nerve injection of FL is sufficient to produce pain hypersensitivity, activate PNP-associated gene expression and generate short-term and long-term sensitization of sensory neurons. Nerve injury-induced PNP symptoms and associated-molecular changes were strongly altered in Flt3-deficient mice or reversed after neuronal FLT3 downregulation in wild-type mice. A first-in-class FLT3 negative allosteric modulator, discovered by structure-based in silico screening, strongly reduced nerve injury-induced sensory hypersensitivity, but had no effect on nociception in non-injured animals. Collectively, our data suggest a new and specific therapeutic approach for PNP., Sensitisation of dorsal root ganglia neurons contributes to neuropathic pain. Here the authors demonstrate the cytokine FL contributes to sensitisation of DRGs via its receptor FLT3 expressed on neurons, and identify a novel FLT3 inhibitor that attenuates neuropathic pain in mice.

Published
2018
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7. Neurite growth acceleration of adult Dorsal Root Ganglion neurons illuminated by low-level Light Emitting Diode light at 645 nm

Author

Burland, Marion, primary, Paris, Lambert, additional, Quintana, Patrice, additional, Bec, Jean-Michel, additional, Diouloufet, Lucie, additional, Sar, Chamroeun, additional, Boukhaddaoui, Hassan, additional, Charlot, Benoit, additional, Braga Silva, Jefferson, additional, Chammas, Michel, additional, Sieso, Victor, additional, Valmier, Jean, additional, and Bardin, Fabrice, additional

Published
2014
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8. Neurite growth acceleration of adult Dorsal Root Ganglion neurons illuminated by low-level Light Emitting Diode light at 645 nm.

Author

Burland, Marion, Paris, Lambert, Quintana, Patrice, Bec, Jean‐Michel, Diouloufet, Lucie, Sar, Chamroeun, Boukhaddaoui, Hassan, Charlot, Benoit, Braga Silva, Jefferson, Chammas, Michel, Sieso, Victor, Valmier, Jean, and Bardin, Fabrice

Abstract

The effect of a 645 nm Light Emitting Diode (LED) light irradiation on the neurite growth velocity of adult Dorsal Root Ganglion (DRG) neurons with peripheral axon injury 4-10 days before plating and without previous injury was investigated. The real amount of light reaching the neurons was calculated by taking into account the optical characteristics of the light source and of media in the light path. The knowledge of these parameters is essential to be able to compare results of the literature and a way to reduce inconsistencies. We found that 4 min irradiation of a mean irradiance of 11.3 mW/cm2 (corresponding to an actual irradiance reaching the neurons of 83 mW/cm2) induced a 1.6-fold neurite growth acceleration on non-injured neurons and on axotomized neurons. Although the axotomized neurons were naturally already in a rapid regeneration process, an enhancement was found to occur while irradiating with the LED light, which may be promising for therapy applications. [ABSTRACT FROM AUTHOR]

Published
2015
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9. Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice.

Author

Rivat C, Sar C, Mechaly I, Leyris JP, Diouloufet L, Sonrier C, Philipson Y, Lucas O, Mallié S, Jouvenel A, Tassou A, Haton H, Venteo S, Pin JP, Trinquet E, Charrier-Savournin F, Mezghrani A, Joly W, Mion J, Schmitt M, Pattyn A, Marmigère F, Sokoloff P, Carroll P, Rognan D, and Valmier J

Subjects
Animals, Blotting, Western, Cells, Cultured, Ganglia, Spinal metabolism, Immunohistochemistry, In Situ Hybridization, Mice, Mice, Inbred C57BL, Neuralgia genetics, Neuralgia metabolism, Peripheral Nervous System Diseases genetics, RNA, Small Interfering genetics, Real-Time Polymerase Chain Reaction, Sensory Receptor Cells metabolism, fms-Like Tyrosine Kinase 3 genetics, Peripheral Nervous System Diseases metabolism, fms-Like Tyrosine Kinase 3 metabolism
Abstract

Peripheral neuropathic pain (PNP) is a debilitating and intractable chronic disease, for which sensitization of somatosensory neurons present in dorsal root ganglia that project to the dorsal spinal cord is a key physiopathological process. Here, we show that hematopoietic cells present at the nerve injury site express the cytokine FL, the ligand of fms-like tyrosine kinase 3 receptor (FLT3). FLT3 activation by intra-sciatic nerve injection of FL is sufficient to produce pain hypersensitivity, activate PNP-associated gene expression and generate short-term and long-term sensitization of sensory neurons. Nerve injury-induced PNP symptoms and associated-molecular changes were strongly altered in Flt3-deficient mice or reversed after neuronal FLT3 downregulation in wild-type mice. A first-in-class FLT3 negative allosteric modulator, discovered by structure-based in silico screening, strongly reduced nerve injury-induced sensory hypersensitivity, but had no effect on nociception in non-injured animals. Collectively, our data suggest a new and specific therapeutic approach for PNP.

Published
2018
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