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5. Evaluation of the impact of iPSC differentiation protocols on transcriptomic signatures

Author

Chandrasekaran, Vidya, Wellens, Sara, Bourguignon, Aurore, Djidrovski, Ivo, Fransen, Leonie, Ghosh, Sreya, Mazidi, Zahra, Murphy, Cormac, Nunes, Carolina, Singh, Pranika, Zana, Melinda, Armstrong, Lyle, Dinnyés, András, Grillari, Johannes, Grillari-Voglauer, Regina, Leonard, Martin O., Verfaillie, Catherine, Wilmes, Anja, Zurich, Marie-Gabrielle, Exner, Thomas, Jennings, Paul, and Culot, Maxime

Published
2024
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11. An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat

Author

Nunes, Carolina, Singh, Pranika, Mazidi, Zahra, Murphy, Cormac, Bourguignon, Aurore, Wellens, Sara, Chandrasekaran, Vidya, Ghosh, Sreya, Zana, Melinda, Pamies, David, Thomas, Aurélien, Verfaillie, Catherine, Culot, Maxime, Dinnyes, Andras, Hardy, Barry, Wilmes, Anja, Jennings, Paul, Grillari, Regina, Grillari, Johannes, Zurich, Marie-Gabrielle, and Exner, Thomas

Published
2022
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14. Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3

Author

Chandrasekaran, Abinaya, Dittlau, Katarina Stoklund, Corsi, Giulia I., Haukedal, Henriette, Doncheva, Nadezhda T., Ramakrishna, Sarayu, Ambardar, Sheetal, Salcedo, Claudia, Schmidt, Sissel I., Zhang, Yu, Cirera, Susanna, Pihl, Maria, Schmid, Benjamin, Nielsen, Troels Tolstrup, Nielsen, Jørgen E., Kolko, Miriam, Kobolák, Julianna, Dinnyés, András, Hyttel, Poul, Palakodeti, Dasaradhi, Gorodkin, Jan, Muddashetty, Ravi S., Meyer, Morten, Aldana, Blanca I., and Freude, Kristine K.

Published
2021
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15. The Current State of Realistic Heart Models for Disease Modelling and Cardiotoxicity.

Author

Kistamás, Kornél, Lamberto, Federica, Vaiciuleviciute, Raminta, Leal, Filipa, Muenthaisong, Suchitra, Marte, Luis, Subías-Beltrán, Paula, Alaburda, Aidas, Arvanitis, Dina N., Zana, Melinda, Costa, Pedro F., Bernotiene, Eiva, Bergaud, Christian, and Dinnyés, András

Subjects
INDUCED pluripotent stem cells, TOXICITY testing, CARDIOVASCULAR diseases, CARDIOTOXICITY, ANIMAL models in research
Abstract

One of the many unresolved obstacles in the field of cardiovascular research is an uncompromising in vitro cardiac model. While primary cell sources from animal models offer both advantages and disadvantages, efforts over the past half-century have aimed to reduce their use. Additionally, obtaining a sufficient quantity of human primary cardiomyocytes faces ethical and legal challenges. As the practically unlimited source of human cardiomyocytes from induced pluripotent stem cells (hiPSC-CM) is now mostly resolved, there are great efforts to improve their quality and applicability by overcoming their intrinsic limitations. The greatest bottleneck in the field is the in vitro ageing of hiPSC-CMs to reach a maturity status that closely resembles that of the adult heart, thereby allowing for more appropriate drug developmental procedures as there is a clear correlation between ageing and developing cardiovascular diseases. Here, we review the current state-of-the-art techniques in the most realistic heart models used in disease modelling and toxicity evaluations from hiPSC-CM maturation through heart-on-a-chip platforms and in silico models to the in vitro models of certain cardiovascular diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Modelling the neuropathology of lysosomal storage disorders through disease-specific human induced pluripotent stem cells

Author

Kobolák, Julianna, Molnár, Kinga, Varga, Eszter, Bock, István, Jezsó, Bálint, Téglási, Annamária, Zhou, Shuling, Lo Giudice, Maria, Hoogeveen-Westerveld, Marianne, Pijnappel, WWM Pim, Phanthong, Phetcharat, Varga, Norbert, Kitiyanant, Narisorn, Freude, Kristine, Nakanishi, Hideyuki, László, Lajos, Hyttel, Poul, and Dinnyés, András

Published
2019
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20. Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human induced pluripotent stem cells

Author

Chandrasekaran, Abinaya, Avci, Hasan X., Ochalek, Anna, Rösingh, Lone N., Molnár, Kinga, László, Lajos, Bellák, Tamás, Téglási, Annamária, Pesti, Krisztina, Mike, Arpad, Phanthong, Phetcharat, Bíró, Orsolya, Hall, Vanessa, Kitiyanant, Narisorn, Krause, Karl-Heinz, Kobolák, Julianna, and Dinnyés, András

Published
2017
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24. Exploring the key deteriorative microorganisms on ancient ivories unearthed from the Sanxingdui Ruins site during temporary cold storage.

Author

Guangjie Lao, Zhiwei Zhou, Rao Wu, Chong Wang, Wei Wu, Shan Lv, Jiancheng Liu, Zhenbin Xie, Dinnyés, András, Haibing Yuan, Xuemei Tan, and Qun Sun

Subjects
COLD storage, IVORY, OXALIC acid, PENICILLIUM, NUCLEOTIDE sequencing, OCHRATOXINS, CITRIC acid, ORGANIC acids
Abstract

Introduction: The ancient ivories unearthed from the Sanxingdui Ruins site are valuable cultural relics, however, the microbial biodeterioration on ivories during temporary cold storage poses a great threat to their later long-term preservation. Methods: Here, the combination of high-throughput sequencing and biochemical assays was applied for the in-depth investigation of the key deteriorative microorganisms colonizing on the ivories and the tracing of their origin, as well as the assessment of the ethanol disinfection impact on the microbial communities on ivories. Results: It was observed that the surfaces of ivories were scattered by the fungal patches of white, dark grey, and hedge green colors during cold storage. The high-throughput sequencing results showed that the genera Mortierella (38.51%), Ilyonectria (14.43%), Penicillium (1.15%), and Aspergillus (1.09%) were the dominant fungi, while Pseudomonas (22.63%), Sphingopyxis (3.06%), and Perlucidibaca (2.92%) were the dominant bacteria on ivories. The isolated Aspergillus A-2 resulted in the highest amount of calcium releasing from the degradation of hydroxyapatite (HAP), the main component of ivory, by the organic acids produced, including oxalic acid and citric acid. The fast expectationmaximization for microbial source tracking (FEAST) analysis revealed that the majority of the fungi (57.45%) and bacteria (71.84%) colonizing on the ivories were derived from the soils surrounding ivories in the sacrifice pits, indicating soils as the primary source for the spoilage microbes growing on ivories. The dominant strains could degrade cellulose, the key components of wet cotton towels commonly applied on ivories for moisture maintenance, aiding the spoilage microbes colonizing on ivories. Notably, the ivory disinfection with 75% ethanol during the cleansing significantly decreased the relative abundance of the dominant genera of Ilyonectria, Aspergillus, and Pseudomonas, with Mortierella becoming the dominant one on ivories. Discussion: Together, the fungi, particularly Aspergillus and Penicillium, played a significant role in the microbial biodeterioration of unearthed ancient ivories by producing the organic acids. These results may improve the control of the microbial biodeterioration and develop more efficient strategies for the longtime conservation of unearthed ancient ivories and other cultural relics. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Towards Understanding Protein Disorder In-Cell

Author

Cedeño, Cesyen, Raveh-Hamit, Hadas, Dinnyés, András, Tompa, Peter, Cohen, Irun R., Series editor, Lajtha, Abel, Series editor, Lambris, John D., Series editor, Paoletti, Rodolfo, Series editor, Felli, Isabella C., editor, and Pierattelli, Roberta, editor

Published
2015
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30. The Effect of an eHealth Coaching Program (Smarter Pregnancy) on Attitudes and Practices Toward Periconception Lifestyle Behaviors in Women Attempting Pregnancy: Prospective Study

Author

Hojeij, Batoul, Schoenmakers, Sam, Willemsen, Sten, van Rossem, Lenie, Dinnyés, András, Rousian, Melek, Steegers-Theunissen, Régine, Hojeij, Batoul, Schoenmakers, Sam, Willemsen, Sten, van Rossem, Lenie, Dinnyés, András, Rousian, Melek, and Steegers-Theunissen, Régine

Abstract

Background: Lifestyle behaviors during the periconception period contribute to achievement of a successful pregnancy. Assessment of attitudes and practices toward these modifiable behaviors can aid in identifying gaps in unhealthy lifestyle behaviors with impact on intervention effectiveness. Objective: This study investigates the effectiveness of coaching by the eHealth program Smarter Pregnancy during the periconception period on improvement of attitudes and practices toward fruit and vegetable intake and smoking in women attempting pregnancy through assisted reproductive technology (ART) or natural conception. Methods: Women attempting pregnancy through ART (n=1060) or natural conception (n=631) were selected during the periconception period. The intervention groups, conceived through ART or naturally, received Smarter Pregnancy coaching for 24 weeks, whereas the control group conceived through ART and did not receive coaching. Attitudes and practices at baseline and follow-up periods were obtained from self-administered online questionnaire provided by the program. Attitudes were assessed in women with unhealthy behaviors as their intention to increase their fruit and vegetable intake and to quit smoking using a yes/no question. Outcomes on practices, suggesting effectiveness, included daily fruit (pieces) and vegetable (grams) intake, and if women smoked (yes/no). Changes in attitudes and practices were compared at 12 and 24 weeks with baseline between the ART intervention and ART control groups, and within the intervention groups between ART and natural conception. Changes in practices at 12 and 24 weeks were also compared with baseline between women with negative attitude and positive attitude within the intervention groups: ART and natural conception. Analysis was performed using linear and logistic regression models adjusted for maternal confounders and baseline attitudes and practices. Results: The ART intervention group showed higher vegetable intake a

Published
2023

36. Rabbit Cloning

Author

Dinnyes, Andras, Polgar, Zsuzsanna, Meng, Qinggang, Houdebine, Louis-Marie, editor, and Fan, Jianglin, editor

Published
2009
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45. Regenerative neurology and regenerative cardiology: Shared hurdles and achievements

Author

Croatian Science Foundation, European Commission, Università degli Studi del Piemonte Orientale “A. Avogadro”, Ministry of Education, Science and Technological Development (Serbia), Medical Research Council (UK), National Innovation Office (Hungary), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, National Science Centre (Poland), Mitrečić, Dinko, Hribljan, Valentina, Jagečić, Denis, Isaković, Jasmina, Lamberto, Federica, Horánszky, Alex, Zana, Melinda, Foldes, Gabor, Zavan, Barbara, Pivoriūnas, Augustas, Martínez, Salvador, Mazzini, Letizia, Radenovic, Lidija, Milasin, Jelena, Chachques, Juan Carlos, Buzanska, Leonora, Song, Min Suk, Dinnyés, András, Croatian Science Foundation, European Commission, Università degli Studi del Piemonte Orientale “A. Avogadro”, Ministry of Education, Science and Technological Development (Serbia), Medical Research Council (UK), National Innovation Office (Hungary), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, National Science Centre (Poland), Mitrečić, Dinko, Hribljan, Valentina, Jagečić, Denis, Isaković, Jasmina, Lamberto, Federica, Horánszky, Alex, Zana, Melinda, Foldes, Gabor, Zavan, Barbara, Pivoriūnas, Augustas, Martínez, Salvador, Mazzini, Letizia, Radenovic, Lidija, Milasin, Jelena, Chachques, Juan Carlos, Buzanska, Leonora, Song, Min Suk, and Dinnyés, András

Abstract

From the first success in cultivation of cells in vitro, it became clear that developing cell and/or tissue specific cultures would open a myriad of new opportunities for medical research. Expertise in various in vitro models has been developing over decades, so nowadays we benefit from highly specific in vitro systems imitating every organ of the human body. Moreover, obtaining sufficient number of standardized cells allows for cell transplantation approach with the goal of improving the regeneration of injured/disease affected tissue. However, different cell types bring different needs and place various types of hurdles on the path of regenerative neurology and regenerative cardiology. In this review, written by European experts gathered in Cost European action dedicated to neurology and cardiology-Bioneca, we present the experience acquired by working on two rather different organs: the brain and the heart. When taken into account that diseases of these two organs, mostly ischemic in their nature (stroke and heart infarction), bring by far the largest burden of the medical systems around Europe, it is not surprising that in vitro models of nervous and heart muscle tissue were in the focus of biomedical research in the last decades. In this review we describe and discuss hurdles which still impair further progress of regenerative neurology and cardiology and we detect those ones which are common to both fields and some, which are field-specific. With the goal to elucidate strategies which might be shared between regenerative neurology and cardiology we discuss methodological solutions which can help each of the fields to accelerate their development.

Published
2022

47. A Novel Multicellular Placental Barrier Model to Investigate the Effect of Maternal Aflatoxin B 1 Exposure on Fetal-Side Neural Stem Cells.

Author

Zhou, Zhiwei, Luo, Dongmei, Li, Mengxue, Lao, Guangjie, Zhou, Zhiqiang, Dinnyés, András, Xu, Wenming, and Sun, Qun

Subjects
NEURAL stem cells, AFLATOXINS, PLACENTA, CENTRAL nervous system, REACTIVE oxygen species, LACTATE dehydrogenase, BILAYER lipid membranes
Abstract

Ingestion of food toxins such as aflatoxin B1 (AFB1) during pregnancy may impair fetal neurodevelopment. However, animal model results may not be accurate due to the species' differences, and testing on humans is ethically impermissible. Here, we developed an in vitro human maternal–fetal multicellular model composed of a human hepatic compartment, a bilayer placental barrier, and a human fetal central nervous system compartment using neural stem cells (NSCs) to investigate the effect of AFB1 on fetal-side NSCs. AFB1 passed through the HepG2 hepatocellular carcinoma cells to mimic the maternal metabolic effects. Importantly, even at the limited concentration (0.0641 ± 0.0046 μM) of AFB1, close to the national safety level standard of China (GB-2761-2011), the mixture of AFB1 crossing the placental barrier induced NSC apoptosis. The level of reactive oxygen species in NSCs was significantly elevated and the cell membrane was damaged, causing the release of intracellular lactate dehydrogenase (p < 0.05). The comet experiment and γ-H2AX immunofluorescence assay showed that AFB1 caused significant DNA damage to NSCs (p < 0.05). This study provided a new model for the toxicological evaluation of the effect of food mycotoxin exposure during pregnancy on fetal neurodevelopment. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Regenerative Neurology and Regenerative Cardiology: Shared Hurdles and Achievements

Author

Mitrečić, Dinko, primary, Hribljan, Valentina, additional, Jagečić, Denis, additional, Isaković, Jasmina, additional, Lamberto, Federica, additional, Horánszky, Alex, additional, Zana, Melinda, additional, Foldes, Gabor, additional, Zavan, Barbara, additional, Pivoriūnas, Augustas, additional, Martinez, Salvador, additional, Mazzini, Letizia, additional, Radenovic, Lidija, additional, Milasin, Jelena, additional, Chachques, Juan Carlos, additional, Buzanska, Leonora, additional, Song, Min Suk, additional, and Dinnyés, András, additional

Published
2022
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50. Environmental alterations during embryonic development: Studying the impact of stressors on pluripotent stem cell-derived cardiomyocytes

Author

Lamberto, Federica, Peral-Sanchez, Irene, Muenthaisong, Suchitra, Zana, Melinda, Willaime-Morawek, Sandrine, and Dinnyés, András

Abstract

Non-communicable diseases (NCDs) sauch as diabetes, obesity and cardiovascular diseases are rising rapidly in all countries world-wide. Environmental maternal factors (e.g., diet, oxidative stress, drugs and many others), maternal illnesses and other stressors can predispose the newborn to develop diseases during different stages of life. The connection between environmental factors and NCDs was formulated by David Barker and colleagues as the Developmental Origins of Health and Disease (DOHaD) hypothesis. In this review, we describe the DOHaD concept and the effects of several environmental stressors on the health of the progeny, providing both animal and human evidence. We focus on cardiovascular diseases which represent the leading cause of death worldwide. The purpose of this review is to discuss how in vitro studies with pluripotent stem cells (PSCs), such as embryonic and induced pluripotent stem cells (ESC, iPSC), can underpin the research on non-genetic heart conditions. The PSCs could provide a tool to recapitulate aspects of embryonic development “in a dish”, studying the effects of environmental exposure during cardiomyocyte (CM) differentiation and maturation, establishing a link to molecular mechanism and epigenetics.

Published
2021

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