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Ninety four patients with thyrotoxicosis were examined as well as 40 healthy subjects. Normal concentration of sodium, negligible chloride increase and slightly decreased potassium were established in serum. Hematocrite drops in parallel with disease severity. The average erythrocyte volume is increased whereas the average hemoglobin concentration is decreased.

The authors report a case with fibroplastic parietal endocarditis with blood eosinophilia (Löffler syndrome II), observed in the course of seven years. The permanent high eosinophilia is of special interest as well as the developed aneurysm of a. pulmonalis. The past history of toxoplasmosis is thought to be the cause for the origination of the disease in the patient. A thorough literature survey on the problem is carried out.

Gastric secretion was investigated in 26 patients, mainly with mature age diabetes and mixed type after a maximal stimulation with pentagastrin (6 microgram/kg). No significant difference was established as compared with the healthy subjects. Hypo- and achlorhydria were found in 19.2 per cent of the patients and hyperchlorhydria in 15.4 per cent. Diabetes duration over 5 years, hyperglycemia over 200 mg%, late degenerative syndrome and insulin treatment reduce significantly the majority of the indices of gastric secretion.

The gastric secretion with pentagastrin was studied in 214 subjects (130 with duodenal ulcer, 20 with double localization--in duodenum and stomach, 32 with gastric ulcer and 32--healthy). A different gastric secretory characteristic was found and the problem raised as regards the differentiated therapeutic and surgical approach in the separate tyoes of ulcer disease. The origination and clinical course of the duodenal ulcer and the ulcer with double localization are admitted to depend most likely and to a greater extent, on the gastric secretion rate. The duration of the active duodenal ulcer probably has no substantial effect on the enhanced secretory function of the stomach in the course of many years. The indices of secretion and acid elimination in single gastric ulcers are significantly diminished.

The age characteristics of gastric secretion were studied in 145 patients with duodenal ulcer and 32 healthy subjects via pentagastrin. With age advancing of the patients, a gradual reduction of gastric secretion and acidity are found, being statistically significant after the age of 49. Apart of that, the average values of the indices for each age group remain considerably higher than the normal. The age, at which the disease originated, has also a certain effect on gastric secretion. Significant reduction is observed after the age of 49, concerning only secretion volume and acidity elimination at basic conditions. The changes found in the gastric secretion and acidity are admitted to possibly play a definite role for the rather unusual course and relatively rare duodenal ulcer origination at the age of 50.

Gastric secretion was investigated in 187 subjects under conditions of maximal stimulation with pentagastrin. Thirty subjects, out of them, were healthy, 30--with gastric ulcer, 110--with duodenal ulcer and 17--with double ulcer localization--in duodenum and stomach. The indices of gastric secretion in duodenal ulcer and ulcer disease with double localization are considerably higher than those on the healthy subjects and differ essentially. With single gastric ulcer they are significantly lower than those of the healthy controls.