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1. Synthesis and α-Glucosidase Inhibitory Activity of Ursolic Acid, Lupeol, and Betulinic Acid Derivatives

Author

Thi-Anh-Tuyet Nguyen, Thuc-Huy Duong, Duc Dung Pham, Jirapast Sichaem, Dinh-Long Huynh, Thi-Thanh-Van Le, and Ngoc-Hong Nguyen

Subjects
chemistry.chemical_compound, chemistry, Ursolic acid, Synthetic derivatives, Stereochemistry, Betulinic acid, Ic50 values, Plant Science, General Chemistry, α glucosidase inhibitory, General Biochemistry, Genetics and Molecular Biology, Lupeol
Abstract

Seven synthetic derivatives of ursolic acid, lupeol, and betulinic acid (1a–1b, 2a–2b, and 3a–3c) were synthesized to study their α-glucosidase inhibitory activity. Three of them (2b, 3b, and 3c) are new compounds. Among the synthetic derivatives, betulinic acid analogues 3b and 3c exhibited the best activity against α-glucosidase and is superior to the positive agent, with IC50 values of 35.0 ± 3.37 and 34.0 ± 1.24 μM, respectively.

Published
2021
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