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A general practitioner's requirements can be described in terms of three levels. These three levels are described and discussed with reference to examples from the author's own experience. [ABSTRACT FROM PUBLISHER]

This study looks at the development of a novel combination vector consisting of adenovirus conjugated to liposomes (AL complexes) bound to cation-exchanging microspheres (MAL complexes). With adenovirus having a net negative charge and the liposomes a net positive charge it was possible to modify the net charge of the AL complexes by varying the concentrations of adenovirus to liposomes. The modification of the net charge resulted in altered binding and release characteristics. Of the complexes tested, the 5:1 and 2:1 ratio AL complexes were able to be efficiently bound by the microspheres and exhibited sustained release over 24 h. The 1:1 and 1:2 AL complexes, however, bound poorly to the microspheres and were rapidly released. In addition the MAL complexes also were able to reduce the toxicity of the AL complexes, which was seen with the 10:1 ratio. The AL complexes showed considerably more toxicity alone than in combination with microspheres, highlighting a potential benefit of this vector.

The story so far_Your intrepid reporter has dragged his sore foot seven blocks from the subway station in downtown Evanston to a rather anonymous-looking office building which almost has a view of the lake.

One of the comforting things about returning to Chicago is that the health care news never changes. A survey of recent stories in the local media reveals some familiar topics. The trauma network, which co-ordinates major accident services, is in crisis because one of the largest private hospitals has pulled out leaving a sizeable gap in coverage for the poorer districts.

We describe a method of studying patterns of prescribing and related morbidity in general practice. Prescribing data were automatically duplicated onto a ;no-carbon-required' prescription-pad. Additional information about diagnosis and indications for each drug, an indication of whether the drug was newly prescribed or a repeat, and a patient identification code were entered onto the bottom copy. A computer was used to process the data, which were gathered over a period of seven months.The method offers an efficient means of collecting data which can be applied by individuals or groups of doctors to improve patient care and help achieve rational prescribing.