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Heart rate (HR) is an important indicator reflecting the overall physical and mental health of the human body, playing a crucial role in diagnosing cardiovascular and neurological diseases. Recent research has revealed that variations in the light absorption of human skin captured through facial video over the cardiac cycle, due to changes in blood volume, can be utilized for non-contact HR estimation. However, most existing methods rely on single-modal video sources (such as RGB or NIR), which often yield suboptimal results due to noise and the limitations of a single information source. To overcome these challenges, this paper proposes a multimodal information fusion architecture named the spatiotemporal sensitive network (SS-Net) for non-contact heart rate estimation. Firstly, spatiotemporal feature maps are utilized to extract physiological signals from RGB and NIR videos effectively. Next, a spatiotemporal sensitive (SS) module is introduced to extract useful physiological signal information from both RGB and NIR spatiotemporal maps. Finally, a multi-level spatiotemporal context fusion (MLSC) module is designed to fuse and complement information between the visible light and infrared modalities. Then, different levels of fused features are refined in task-specific branches to predict both remote photoplethysmography (rPPG) signals and heart rate (HR) signals. Experiments conducted on three datasets demonstrate that the proposed SS-Net achieves superior performance compared to existing methods. [ABSTRACT FROM AUTHOR]

Immunogenic cell death (ICD) approaches by encumbering mitochondrial functions provide great promise for the treatment of malignant tumors, but these kinds of ICD strategies are still in their infancy. Here, one multifunctional drug‐loaded, cascade‐targeted, and enzyme‐instructed self‐assembling peptide nanomedicine (Comp. 4) for ICD‐based cancer therapy is constructed. Comp. 4 consists of 1) lonidamine (LND) that specifically interferes with mitochondrial functions; 2) a programmed death ligand 1 (PD‐L1) binding peptide sequence (NTYYEDQG) and a mitochondria‐specific motif (triphenylphosphonium, TPP) that can sequentially control the cell membrane and mitochondria targeting capacities, respectively; and 3) a ‐GDFDFpDY‐ assembly core to in situ organize peptide assemblies responsive to alkaline phosphatase (ALP). Comp. 4 demonstrates noticeable structural and morphological transformations in the presence of ALP and produces peptide assemblies in mouse colon cancer cells (CT26) with high expressions of both ALP and PD‐L1. Moreover, the presence of PD‐L1‐ and mitochondria‐specific motifs can assist Comp. 4 for effective endocytosis and endosomal escape, forming peptide assemblies and delivering LND into mitochondria. Consequently, Comp. 4 shows superior capacities to in vivo induce abundant mitochondrial oxidative stress, provoke robust ICD responses, and produce an immunogenic tumor microenvironment, successfully inhibiting CT26 tumor growth by eliciting a systemic ICD‐based antitumor immunity. [ABSTRACT FROM AUTHOR]

The article titled "Copper-Induced Supramolecular Peptide Assemblies for Multi-Pathway Cell Death and Tumor Inhibition" discusses the issue of immunosuppressive tumor microenvironments and their impact on anti-tumor immune responses. The cover image of the article depicts tumor cells as icebergs with organelles as ice blocks, while copper peptide nanoparticles are represented as meteorites attacking the organelles. The melting ice symbolizes the activation of multiple cell death pathways and the transformation of cold tumors into hot tumors. The research article, authored by Ling Wang, Jie Gao, and others, provides further details on this topic. [Extracted from the article]

The article titled "Back Cover: Copper-Induced Supramolecular Peptide Assemblies for Multi-Pathway Cell Death and Tumor Inhibition" discusses the issue of immunosuppressive tumor microenvironments and their impact on anti-tumor immune responses. The cover image depicts tumor cells as icebergs with copper peptide nanoparticles falling from the sky, attacking multiple organelles and causing the ice to melt. This symbolizes the activation of multiple cell death pathways and the transformation of "cold" tumors into "hot" tumors. The research article, authored by Ling Wang, Jie Gao, and others, provides further details on this topic. [Extracted from the article]