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Your search keyword '"Ding, Xu-Fen"' showing total 11 results
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11 results on '"Ding, Xu-Fen"'

7. PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling

Author

Ma, Ning, Wang, Yi-Kang, Xu, Sheng, Ni, Qian-Zhi, Zheng, Qian-Wen, Zhu, Bing, Cao, Hui-Jun, Jiang, Hao, Zhang, Feng-Kun, Yuan, Yan-Mei, Zhang, Er-Bin, Chen, Tian-Wei, Xia, Ji, Ding, Xu-Fen, Chen, Zhen-Hua, Zhang, Xiu-Ping, Wang, Kang, Cheng, Shu-Qun, Qiu, Lin, Li, Zhi-Gang, Yu, Yong-Chun, Wang, Xiao-Fan, Zhou, Bin, Li, Jing-Jing, and Xie, Dong

Published
2021
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8. PPDPF Promotes the Development of Mutant KRAS‐Driven Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1

Author

Ni, Qian‐Zhi, primary, Zhu, Bing, additional, Ji, Yan, additional, Zheng, Qian‐Wen, additional, Liang, Xin, additional, Ma, Ning, additional, Jiang, Hao, additional, Zhang, Feng‐Kun, additional, Shang, Yu‐Rong, additional, Wang, Yi‐Kang, additional, Xu, Sheng, additional, Zhang, Er‐Bin, additional, Yuan, Yan‐Mei, additional, Chen, Tian‐Wei, additional, Yin, Fen‐Fen, additional, Cao, Hui‐Jun, additional, Huang, Jing‐Yi, additional, Xia, Ji, additional, Ding, Xu‐Fen, additional, Qiu, Xiao‐Song, additional, Ding, Kai, additional, Song, Chao, additional, Zhou, Wen‐Tao, additional, Wu, Meng, additional, Wang, Kang, additional, Lui, Rui, additional, Lin, Qiu, additional, Chen, Wei, additional, Li, Zhi‐Gang, additional, Cheng, Shu‐Qun, additional, Wang, Xiao‐Fan, additional, Xie, Dong, additional, and Li, Jing‐Jing, additional

Published
2022
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9. ARID2 mitigates hepatic steatosis via promoting the ubiquitination of JAK2

Author

Cao, Hui-Jun, primary, Jiang, Hao, additional, Ding, Kai, additional, Qiu, Xiao-Song, additional, Ma, Ning, additional, Zhang, Feng-Kun, additional, Wang, Yi-Kang, additional, Zheng, Qian-Wen, additional, Xia, Ji, additional, Ni, Qian-Zhi, additional, Xu, Sheng, additional, Zhu, Bing, additional, Ding, Xu-Fen, additional, Chen, Tian-Wei, additional, Qiu, Lin, additional, Chen, Wei, additional, Li, Zhi-Gang, additional, Zhou, Bin, additional, Feng, Wen-Ming, additional, Xie, Dong, additional, and Li, Jing-Jing, additional

Published
2022
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10. PPDPF Promotes the Development of Mutant KRAS‐Driven Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1.

Author

Ni, Qian‐Zhi, Zhu, Bing, Ji, Yan, Zheng, Qian‐Wen, Liang, Xin, Ma, Ning, Jiang, Hao, Zhang, Feng‐Kun, Shang, Yu‐Rong, Wang, Yi‐Kang, Xu, Sheng, Zhang, Er‐Bin, Yuan, Yan‐Mei, Chen, Tian‐Wei, Yin, Fen‐Fen, Cao, Hui‐Jun, Huang, Jing‐Yi, Xia, Ji, Ding, Xu‐Fen, and Qiu, Xiao‐Song

Subjects
PANCREATIC duct, GUANINE nucleotide exchange factors, GENETIC models, ADENOCARCINOMA
Abstract

The guanine nucleotide exchange factor (GEF) SOS1 catalyzes the exchange of GDP for GTP on RAS. However, regulation of the GEF activity remains elusive. Here, the authors report that PPDPF functions as an important regulator of SOS1. The expression of PPDPF is significantly increased in pancreatic ductal adenocarcinoma (PDAC), associated with poor prognosis and recurrence of PDAC patients. Overexpression of PPDPF promotes PDAC cell growth in vitro and in vivo, while PPDPF knockout exerts opposite effects. Pancreatic‐specific deletion of PPDPF profoundly inhibits tumor development in KRASG12D‐driven genetic mouse models of PDAC. PPDPF can bind GTP and transfer GTP to SOS1. Mutations of the GTP‐binding sites severely impair the tumor‐promoting effect of PPDPF. Consistently, mutations of the critical amino acids mediating SOS1–PPDPF interaction significantly impair the GEF activity of SOS1. Therefore, this study demonstrates a novel model of KRAS activation via PPDPF‐SOS1 axis, and provides a promising therapeutic target for PDAC. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis

Author

Zheng, Qian-Wen, primary, Ding, Xu-Fen, additional, Cao, Hui-Jun, additional, Ni, Qian-Zhi, additional, Zhu, Bing, additional, Ma, Ning, additional, Zhang, Feng-Kun, additional, Wang, Yi-Kang, additional, Xu, Sheng, additional, Chen, Tian-Wei, additional, Xia, Ji, additional, Qiu, Xiao-Song, additional, Yu, Dian-Zhen, additional, Xie, Dong, additional, and Li, Jing-Jing, additional

Published
2021
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