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Additional file 1: Figure S1. The TCGA cohort patients formed clusters of: (1) benign (n=36), (2) early development and differentiation (n=86), (3) transition (n=36), and (4) QM-PDA (n=20) based on differential gene expression patterns.

Additional file 6: Table S1. Survival analysis of VAV1 targeted the cell cycle pathway gene network and cytokeratin 6B expression in a combined analysis of 1207 pancreatic cancer samples from 10 studies included in the cBioPortal [61, 62].

Additional file 7: Table S2. Details of reagents and materials. #, not available; *, in the TSA IHC Kit a higher dilution factor was chosen for optimized signal to background ratio.

Additional file 2: Figure S2. Collection of AATK expression in ADM in KC mice. Insert, higher magnification of Fig. 7a, region 1.

Additional file 3: Figure S3. miR-338-3p in situ hybridization in adjacent normal and tumoral sections of pancreatic cancer. U6 snRNA expression was used as positive control.

Additional file 4: Figure S4. The individual features of human pancreatic cancer and adjacent normal tissue sections.

A novel multifunctional inorganic-organic photorefractive (PR) poly(N-vinyl)-3-[p-nitrophenylazolcarbazolyl-CdS nanocomposites with different molar ratios of US to poly(N-vinyl)-3-[p-nitrophenylazo]carbazolyl (PVNPAK) were synthesized via a postazo-coupling reaction and chemically hybridized approach, respectively. The nanocomposites are highly soluble and could be obtained as film-forming materials with appreciably high molecular weights and low glass transition temperature (T,) due to the flexible spacers. The PVNPAK matrix possesses a highest-occupied molecular orbital value of about -5.36 eV determined from cyclic voltammetry. Second harmonic generation (SHG) could be observed in PVNPAK film without any poling procedure and 4.7 pm/V of effective second-order nonlinear optical susceptibility is obtained. The US particles as photosensitizers had a nanoscale size in PVNPAK adopting transmission electron microscopy. The improvement of interface quality between US and polymer matrix is responsible for efficient photoinduced charge generation efficiency in the nanocomposites. An asymmetric optical energy exchange between two beams on the polymer composites PVNPAK-CdS/ECZ has been found even without an external field in two-beam coupling (TBC) experiment, and the TBC gain and diffraction efficiency of 14.26 cm(-1) and 3.4% for PVNPAK-5-CdS/ECZ, 16.43 cm(-1) and 4.4% for PVNPAK-15-CdS/ECZ were measured at a 647.1 nm wavelength, respectively.