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Your search keyword '"Ding, Jia-Tong"' showing total 17 results
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17 results on '"Ding, Jia-Tong"'

9. Cloning of Rabbit Bone Morphogenetic Protein 15 and Its Expression During in vitro Maturation of Rabbit Oocytes

Author

JI Jing-qiang, Li Lin, Ding Jia-tong, and Yin Ping

Subjects
chemistry.chemical_classification, Cloning, endocrine system, Bone morphogenetic protein 15, urogenital system, Rabbit (nuclear engineering), Cumulus Cell, Biology, Molecular biology, In vitro maturation, Andrology, chemistry, Expression pattern, Nucleotide, Partial cdna
Abstract

Partial cDNA sequence of rabbit BMP15 was cloned by RT-PCR from rabbit ovaries, showing a similarity of 83%−90% with the BMP15 nucleotide sequences in humans, mice, ovine, sheep, cows and pigs. The expression of BMP15 in rabbit cumulus-oocyte complexs during oocytes in vitro maturation (IVM) was measured by fluorescent quantitative RT-PCR method. BMP15 was expressed at low levels in immature oocytes and increased to the highest level at 16 h of IVM, which coincides with the time of cumulus cell expansion, then declined slowly under IVM cultivation. The expression pattern of BMP15 suggested that it might be important in cumulus expansion in rabbits.

Published
2009
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17. Landscapes and mechanisms of CD8 + T cell exhaustion in gastrointestinal cancer.

Author

Ding JT, Yang KP, Zhou HN, Huang YF, Li H, and Zong Z

Subjects
Humans, CD8-Positive T-Lymphocytes, Epigenesis, Genetic, T-Cell Exhaustion, Antibodies, Gastrointestinal Neoplasms therapy, Stomach Neoplasms
Abstract

CD8 + T cells, a cytotoxic T lymphocyte, are a key component of the tumor immune system, but they enter a hyporeactive T cell state in long-term chronic inflammation, and how to rescue this depleted state is a key direction of research. Current studies on CD8 + T cell exhaustion have found that the mechanisms responsible for their heterogeneity and differential kinetics may be closely related to transcription factors and epigenetic regulation, which may serve as biomarkers and potential immunotherapeutic targets to guide treatment. Although the importance of T cell exhaustion in tumor immunotherapy cannot be overstated, studies have pointed out that gastric cancer tissues have a better anti-tumor T cell composition compared to other cancer tissues, which may indicate that gastrointestinal cancers have more promising prospects for the development of precision-targeted immunotherapy. Therefore, the present study will focus on the mechanisms involved in the development of CD8 + T cell exhaustion, and then review the landscapes and mechanisms of T cell exhaustion in gastrointestinal cancer as well as clinical applications, which will provide a clear vision for the development of future immunotherapies., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Ding, Yang, Zhou, Huang, Li and Zong.)

Published
2023
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