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This study was conducted to analyze the effect of entrepreneurial orientation on company performance through strategic agility. This research uses the SEM analysis method with WarpPLS software. The sample of this study consisted of 204 actors and strategic decision-makers of green economy SMEs in Malang areas. The unit of analysis in this study is the green economy SME business players in the business of flower, fruit, and ornamental plants. This business field was chosen because it is environmentally friendly, the waste has minimal risk of environmental damage, and this business is at the same time healthy for the environment for business people, employees, and consumers. Data collection was collected by distributing questionnaires directly or via a Google Form. This study proves that entrepreneurial orientation has a direct and positive effect on improving company performance. This study has proven that entrepreneurial orientation positively affects company performance both directly and through strategic agility, so it can be concluded that strategic agility can partially mediate the effect of entrepreneurial orientation on company performance. The application of strategic agility/agility is proven to improve company performance. This study can enrich the study of strategic management theory in the context of Strategic Agility in a green economy. SMEs’ owners and managers improve their performance by increasing entrepreneurial orientation and strengthening strategic agility.

To investigate the effects of steel support cross-section dimensions and preloaded axial force levels on the stability of foundation pits, numerical simulations were conducted for open-cut deep foundation pits based on monitoring data from Changchun Metro Line 9. Results show that increasing the wall thickness and diameter of the steel support significantly reduces the horizontal displacement and axial force of the enclosure pile. When the wall thickness increases from 14 mm to 25 mm, the horizontal displacement of the enclosure pile can be reduced by up to 7.63 mm, and the axial force of the steel support can be reduced by 11.4–15%. When the diameter of the steel support changes from 609 mm to 800 mm, the axial force of the second steel support is reduced by 3.2–5.5%. The change in preloaded axial force results in a horizontal displacement change of about 3–5 mm and a surface settlement change of about 0.6–4.2 mm. The preloaded axial force meets pit stability control requirements when it reaches 60% of the design axial force. [ABSTRACT FROM AUTHOR]

Objectives: Confirm that stem cells from human exfoliated deciduous teeth‐derived exosomes (SHED‐exos) can limit inflammation‐triggered epithelial cell apoptosis and explore the molecular mechanism. Methods: SHED‐exos were injected into the submandibular glands (SMGs) of non‐obese diabetic (NOD) mice, an animal model of Sjögren's syndrome (SS). Cell death was evaluated by western blotting and terminal deoxynucleotidyl transferase‐mediated dUTP nick‐end labelling staining. Results: SHED‐exos treatment promoted the saliva flow rates of NOD mice, accompanied by decreased cleaved caspase‐3 levels and apoptotic cell numbers in SMGs. SHED‐exos inhibited autophagy, pyroptosis, NETosis, ferroptosis, necroptosis and oxeiptosis marker expression in SS‐damaged glands. Mechanistically, Kyoto Encyclopedia of Genes and Genomes analysis of exosomal miRNAs suggested that the rat sarcoma virus (RAS)/mitogen‐activated protein kinase kinase (MEK)/extracellular signal‐regulated kinase (ERK) pathway might play an important role. In vivo, the expression of Kirsten RAS, Harvey RAS, MEK1/2 and p‐ERK1/2 was upregulated in SMGs, and this change was blocked by SHED‐exos treatment. In vitro, SHED‐exos suppressed p‐ERK1/2 activation and increased cleaved caspase‐3 and apoptotic cell numbers, which were induced by IFN‐γ. Conclusion: SHED‐exos suppress epithelial cell death, which is responsible for promoting salivary secretion. SHED‐exos inhibited inflammation‐triggered epithelial cell apoptosis by suppressing p‐ERK1/2 activation, which is involved in these effects. [ABSTRACT FROM AUTHOR]

Autonomous berthing technology is a crucial engineering control problem within the ship intelligence system, encompassing a series of complex operations and technologies. Firstly, this paper analyses the research on autonomous berthing technology from a bibliometric point of view in order to obtain an overview of its past and present development and to outline the importance of this technology. Secondly, a literature review is conducted on each of the four aspects of autonomous berthing technology, namely sensing technology, berthing type, control method, and evaluation method, which can help to quickly understand the main aspects of this technology. Thirdly, the ship-assisting technologies needed to achieve autonomous berthing are discussed and analysed from six aspects: dynamic collision avoidance, path planning, path tracking, heading control, tug assistance, and shore-based systems. Finally, the challenges faced by the ship autonomous berthing technology on the way of development are summarised, and future development is projected. This paper aims to provide a more comprehensive perspective for analysing and researching ship autonomous berthing technology. [ABSTRACT FROM AUTHOR]

Objectives: The objective of the study was to evaluate the therapeutic effects of carbon quantum dots (CQDs) in immunomodulation on non‐obese diabetic (NOD) mice, as the model for Sjögren's syndrome (SS). Methods: Carbon quantum dots were generated from Setaria viridis via a hydrothermal process. Their toxic effects were tested by cell viability and blood chemistry analysis, meanwhile therapeutic effects were investigated in NOD mice in the aspects of saliva flow, histology, and immune cell distribution. Results: Carbon quantum dots, with rich surface chemistry and unique optical properties, showed non‐cytotoxicity in vitro or no damage in vivo. Intravenously applied CQDs alleviated inflammation in the submandibular glands in NOD mice after 6‐week treatments. The inflammatory area index and focus score were significantly decreased in CQD‐treated mice. Besides, the levels of anti‐SSA and anti‐SSB were decreased in the presence of CQDs. The stimulated saliva flow rates and weight of submandibular glands were significantly increased in CQD‐treated mice by reducing the apoptosis of cells. The CD3+ and CD4+ T cells distributed around the ducts of submandibular glands were significantly decreased, while the percentage of Foxp3+ cells was higher in CQD‐treated mice than that in the control group. Conclusions: Our findings suggest that CQDs may ameliorate the dysregulated immune processes in NOD mice. [ABSTRACT FROM AUTHOR]