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4 results on '"Dimapilis, Virginia O"'

1. A prospective observational study of community-acquired bacterial bloodstream infections in Metro Manila, the Philippines

Author

Saito, Nobuo, primary, Solante, Rontgene M., additional, Guzman, Ferdinand D., additional, Telan, Elizabeth O., additional, Umipig, Dorcas V., additional, Calayo, Joy P., additional, Frayco, Carina H., additional, Lazaro, Jezreel C., additional, Ribo, Maricel R., additional, Dimapilis, Alexis Q., additional, Dimapilis, Virginia O., additional, Villanueva, Annavi M., additional, Mauhay, Jaira L., additional, Suzuki, Motoi, additional, Yasunami, Michio, additional, Koizumi, Nobuo, additional, Kitashoji, Emi, additional, Sakashita, Kentaro, additional, Yasuda, Ikkoh, additional, Nishiyama, Akira, additional, Smith, Chris, additional, Ariyoshi, Koya, additional, and Parry, Christopher M., additional

Published
2022
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2. Diphtheria in Metro Manila, the Philippines 2006–2017: A Clinical, Molecular, and Spatial Characterization

Author

Parry, Christopher M, Ariyoshi, Koya, Smith, Chris, Toda, Kohei, Nakayama, Fumihito, Salva, Eumelia P, De Guzman, Ferdinand, Dimapilis, Alexis Q, Solante, Rontgene M, Umipig, Dorcas Valencia, Telan, Elizabeth Freda O, Suzuki, Motoi, Fujii, Hiroshi, Dimapilis, Virginia O, Saito, Nobuo, Parry, Christopher M, Ariyoshi, Koya, Smith, Chris, Toda, Kohei, Nakayama, Fumihito, Salva, Eumelia P, De Guzman, Ferdinand, Dimapilis, Alexis Q, Solante, Rontgene M, Umipig, Dorcas Valencia, Telan, Elizabeth Freda O, Suzuki, Motoi, Fujii, Hiroshi, Dimapilis, Virginia O, and Saito, Nobuo

Abstract

BACKGROUND: Diphtheria is a vaccine-preventable disease that persists as a global health problem. An understanding of the pattern of disease is lacking in low- and middle-income countries such as the Philippines. METHODS: We conducted a retrospective review of the clinical, microbiological, and epidemiological features of patients admitted with a clinical diagnosis of diphtheria to an infectious disease referral hospital in Metro Manila, the Philippines, between 2006 and 2017. Cases were mapped and the distribution was compared with population density. Corynebacterium diphtheriae isolates from between 2015 and 2017 were examined by multilocus sequence typing (MLST). RESULTS: We studied 267 patients (range:12-54 cases/year) admitted between 2006 and 2017. The case fatality rate (CFR) was 43.8% (95% confidence interval, 37.8-50.0%). A higher number of cases and CFR was observed among children <10 years. Mortality was associated with a delayed admission to hospital and a lack of diphtheria antitoxin. Between 2015 and 2017 there were 42 laboratory-confirmed cases. We identified 6 multilocus sequence types (STs). ST-302 was the most common (17/34, 48.6%), followed by ST67 (7/34, 20%) and ST458 (5/34, 14%). Case mapping showed a wide distribution of diphtheria patients in Metro Manila. Higher case numbers were found in densely populated areas but with no apparent clustering of ST types. CONCLUSIONS: Our analysis indicates that diphtheria remains endemic in Metro Manila and that the infection is frequently fatal in young children. Improved vaccine coverage and a sustainable supply of diphtheria antitoxin should be prioritized., Clinical infectious diseases, 72(1), pp.61-68; 2021

Published
2020

3. Diphtheria in Metro Manila, the Philippines 2006–2017: A Clinical, Molecular, and Spatial Characterization

Author

Saito, Nobuo, primary, Dimapilis, Virginia O, primary, Fujii, Hiroshi, primary, Suzuki, Motoi, primary, Telan, Elizabeth Freda O, primary, Umipig, Dorcas Valencia, primary, Solante, Rontgene M, primary, Dimapilis, Alexis Q, primary, De Guzman, Ferdinand, primary, Salva, Eumelia P, primary, Nakayama, Fumihito, primary, Toda, Kohei, primary, Smith, Chris, primary, Ariyoshi, Koya, primary, and Parry, Christopher M, primary

Published
2020
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4. Diphtheria in Metro Manila, the Philippines 2006–2017: A Clinical, Molecular, and Spatial Characterization.

Author

Saito, Nobuo, Dimapilis, Virginia O, Fujii, Hiroshi, Suzuki, Motoi, Telan, Elizabeth Freda O, Umipig, Dorcas Valencia, Solante, Rontgene M, Dimapilis, Alexis Q, Guzman, Ferdinand De, Salva, Eumelia P, Nakayama, Fumihito, Toda, Kohei, Smith, Chris, Ariyoshi, Koya, and Parry, Christopher M

Subjects
*CONFIDENCE intervals, *DIPHTHERIA, *DIPHTHERIA antitoxin, *PUBLIC health, *VACCINATION, *RETROSPECTIVE studies, *DESCRIPTIVE statistics
Abstract

Background Diphtheria is a vaccine-preventable disease that persists as a global health problem. An understanding of the pattern of disease is lacking in low- and middle-income countries such as the Philippines. Methods We conducted a retrospective review of the clinical, microbiological, and epidemiological features of patients admitted with a clinical diagnosis of diphtheria to an infectious disease referral hospital in Metro Manila, the Philippines, between 2006 and 2017. Cases were mapped and the distribution was compared with population density. Corynebacterium diphtheriae isolates from between 2015 and 2017 were examined by multilocus sequence typing (MLST). Results We studied 267 patients (range:12−54 cases/year) admitted between 2006 and 2017. The case fatality rate (CFR) was 43.8% (95% confidence interval, 37.8−50.0%). A higher number of cases and CFR was observed among children <10 years. Mortality was associated with a delayed admission to hospital and a lack of diphtheria antitoxin. Between 2015 and 2017 there were 42 laboratory-confirmed cases. We identified 6 multilocus sequence types (STs). ST-302 was the most common (17/34, 48.6%), followed by ST67 (7/34, 20%) and ST458 (5/34, 14%). Case mapping showed a wide distribution of diphtheria patients in Metro Manila. Higher case numbers were found in densely populated areas but with no apparent clustering of ST types. Conclusions Our analysis indicates that diphtheria remains endemic in Metro Manila and that the infection is frequently fatal in young children. Improved vaccine coverage and a sustainable supply of diphtheria antitoxin should be prioritized. [ABSTRACT FROM AUTHOR]

Published
2021
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