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368 results on '"Dilworth, M"'

23. A multicentre cohort study assessing day of week effect and outcome from emergency appendicectomy

Author

Ferguson, Henry JM, Hall, Nigel J, Bhangu, Aneel, Panagiotopoulou, I G, Chatzizacharias, N, Rana, M, Rollins, K, Ejtehadi, F, Jha, B, Tan, Y W, Fanous, N, Markides, G, Tan, A, Marshal, C, Akhtar, S, Mullassery, D, Ismail, A, Hitchins, C, Sharif, S, Osborne, L, Sengupta, N, Challand, C, Pournaras, D, Bevan, K, King, J, Massey, J, Sandhu, I, Wells, J M, Teichmann, D A, Peckham-Cooper, A, Sellers, M, Folaranmi, S E, Davies, B, Potter, S, Egbeare, D, Kallaway, C, Parsons, S, Upchurch, E, Lazaridis, A, Cocker, D, King, D, Behar, N, Loukogeorgakis, S P, Kalaiselvan, R, Marzouk, S, Turner, E J H, Kaptanis, S, Kaur, V, Shingler, G, Bennett, A, Shaikh, S, Aly, M, Coad, J, Khong, T, Nouman, Z, Crawford, J, Szatmary, P, West, H, Lambert, J, Gash, K, Hanks, K A, Griggs, E, Humphreys, L, Torrance, A, Hardman, J, Taylor, L, Rex, D, Bennett, J, Crowther, N, McAree, B, Flexer, S, Mistry, P, Jain, P, Hwang, M, Oswald, N, Wells, A, Newsome, H, Martinez, P, Alvarez, C A B, León, J, Carradice, D, Gohil, R, Mount, M, Campbell, A, Iype, S, Dyson, E, Groot-Wassink, T, Ross, A R, Jones, C, Charlesworth, P, Baylem, N, Voll, J, Sian, T, Creedon, L, Hicks, G, Goring, J, Ng, V, Tiboni, S, Palser, T, Rees, B, Ravindra, P, Neophytou, C, Dent, H, Lo, T, Broom, L, OʼConnell, M, Foulkes, R, Griffith, D, Butcher, K, Mclaren, O, Tai, A, Yano, H, Torrance, H D T, Moussa, O, Mittapalli, D, Watt, D, Basson, S, Gilliland, J, Pilgrim, S, Wilkins, A, Yee, J, Cain, H, Wilson, M, Pearson, J, Turnbull, E, Brigic, A, Yassin, N A, Clarke, J, Mallappa, S, Jackson, P, Jones, C, Lakshminarayanan, B, Sharma, A, Velineni, R, Fareed, K, Yip, G, Brown, A, Patel, N, Ghisel, M, Tanner, N, Jones, H, Witherspoon, J, Phillips, M, Ho, M F, Ng, S, Mak, T, Campain, N, Mukhey, D, Mitchell, W K, Amawi, F, Dickson, E, Aggarwal, S, Satherley, L K, Asprou, F, Keys, C, Steven, M, Johnstone, M, Muhlschlegel, J, Hamilton, E, Yin, J, Dilworth, M, Wright, A, Spreadborough, P, Singh, M, Mockford, K, Morgan, J, Ball, W, Royle, J, Lacy-Colson, J, Lai, W, Griffiths, S, Mitchell, S, Parsons, C, Joel, A S, Mason, P F, Harrison, G J, Steinke, J, Rafique, H, Battersby, C, Hawkins, W, Gurram, D, Hateley, C A, Penkethman, A, Lambden, C, Conway, A, Dent, P, Yacob, D, Oshin, O A, Hargreaves, A, Gossedge, G, Long, J, Walls, M, Futaba, K, Pinkney, T, Puig, S, Boddy, A, Jones, A, Tennuci, C, Battersby, N, Wilkin, R, Lloyd, C, Sein, E, McEvoy, K, Whisker, L, Austin, S, Colori, A, Sinclair, P, Loughran, M, Lawrence, A, Horsnell, J, Bagenal, J, Pisesky, A, Mastoridis, S, Solanki, K, Siddiq, I, Merker, L, Sarmah, P, Richardson, C, Hanratty, D, Evans, L, Mortimer, M, Bhalla, A, Bartlett, D, Beral, D, Blencowe, N S, Cornish, J, Haddow, J B, Hall, N J, Johnstone, M, Pilgrim, S, Strong, S, Velineni, R, Marriot, P, Vohra, R, Patel, A, Poon, H, and Hepburn, E

Published
2014
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47. Antenatal sildenafil citrate treatment increases offspring blood pressure in the placental-specific Igf2 knockout mouse model of FGR.

Author

Renshall, L. J., Cottrell, E. C., Cowley, E., Sibley, C. P., Baker, P. N., Thorstensen, E. B., Greenwood, S. L., Wareing, M., and Dilworth, M. R.

Subjects
BLOOD pressure, SOMATOMEDIN A, SYSTOLIC blood pressure, KNOCKOUT mice, VASCULAR resistance
Abstract

Fetal growth restriction (FGR), where a fetus fails to reach its genetic growth potential, affects up to 8% of pregnancies and is a major risk factor for stillbirth and adulthood morbidity. There are currently no treatments for FGR, but candidate therapies include the phosphodiesterase-5 inhibitor sildenafil citrate (SC). Randomized clinical trials in women demonstrated no effect of SC on fetal growth in cases of severe early onset FGR; however, long-term health outcomes on the offspring are unknown. This study aimed to assess the effect of antenatal SC treatment on metabolic and cardiovascular health in offspring by assessing postnatal weight gain, glucose tolerance, systolic blood pressure, and resistance artery function in a mouse model of FGR, the placental-specific insulin-like growth factor 2 (PO) knockout mouse. SC was administered subcutaneously (10 mg/kg) daily from embryonic day (E)12.5. Antenatal SC treatment did not alter fetal weight or viability but increased postnatal weight gain in wild-type (WT) female offspring (P < 0.05) and reduced glucose sensitivity in both WT (P < 0.01) and P0 (P < 0.05) female offspring compared with controls. Antenatal SC treatment increased systolic blood pressure in both male (WT vs. WT-SC: 117 ± 2 vs. 140 ± 3 mmHg, P < 0.0001; P0 vs. P0-SC: 113 ± 3 vs. 140 ± 4 mmHg, P < 0.0001; means ± SE) and female (WT vs. WT-SC: 121 ± 2 vs. 140 ± 2 mmHg, P < 0.0001; P0 vs. P0-SC: 117 ± 2 vs. 144 ± 4 mmHg, P < 0.0001) offspring at 8 and 13 wk of age. Increased systolic blood pressure was not attributed to altered mesenteric artery function. In utero exposure to SC may result in metabolic dysfunction and elevated blood pressure in later life. [ABSTRACT FROM AUTHOR]

Published
2020
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48. Epigenetic biomarkers in progression from non-dysplastic Barrett's oesophagus to oesophageal adenocarcinoma: a systematic review protocol

Author

Nieto, T, Tomlinson, C L, Dretzke, J, Bayliss, S, Dilworth, M, Beggs, A D, and Tucker, O

Subjects
Epigenomics, Esophageal Neoplasms, Endoscopy, Gastroenterology and Hepatology, Adenocarcinoma, Prognosis, Barrett Esophagus, Protocol, Disease Progression, Gastroesophageal Reflux, Humans, Barrett's Oesophagus, Cancer Epigenetics, Systematic Review, Prospective Studies, Precancerous Conditions, Cancer Screening, Biomarkers, Oesophageal Adenocarcinoma, Retrospective Studies, Systematic Reviews as Topic
Abstract

Introduction Barrett's oesophagus (BO), a metaplastic condition affecting the lower oesophagus due to long-standing gastro-oesophageal reflux and chronic inflammation, is a precursor lesion for oesophageal adenocarcinoma (OADC). There is no clinical test to predict which patients with BO will progress to OADC. The British Society of Gastroenterology recommends endoscopic surveillance of patients with BO. Epigenetic changes have been well characterised in the neoplastic progression of ulcerative colitis to colonic carcinoma, another gastrointestinal cancer associated with chronic inflammation. This systematic review protocol aims to identify and evaluate studies which examine epigenetic biomarkers in BO and their association with progression to OADC. Methods and analysis All prospective and retrospective primary studies, and existing systematic reviews investigating epigenetic markers including DNA methylation, histone modification, chromatin remodelling, micro and non-coding RNAs of all types will be eligible for inclusion. Eligible patients are those over the age of 18 with BO, BO with dysplasia, OADC or unspecified oesophageal cancer. A comprehensive search of bibliographic databases using combinations of text and index words relating to the population, prognostic markers and outcome will be undertaken with no language restrictions. Results will be screened by 2 independent reviewers and data extracted using a standardised proforma. The quality and risk of bias of individual studies will be assessed using the Quality in Prognostic Studies (QUIPS) tool. A narrative synthesis of all evidence will be performed with key findings tabulated. Meta-analysis will be considered where studies and reported outcomes are considered sufficiently homogeneous, both clinically and methodologically. Findings will be interpreted in the context of the quality of included studies. The systematic review will be reported according to PRISMA guidelines. Ethics and dissemination This is a systematic review of completed studies and no ethical approval is required. Findings from the full systematic review will be submitted for publication and presentation at national and international conferences which will inform future research on risk stratification in patients with BO. Review registration number CRD42016038654.

Published
2016

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