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9 results on '"Dilophus spiralis"'

1. Isolation and Structure Elucidation of Three New Dolastanes from the Brown Alga Dilophus spiralis

Author

Vassilios Roussis, Constantinos Vagias, and Efstathia Ioannou

Subjects
Dilophus spiralis, dolastanes, structure elucidation, Biology (General), QH301-705.5
Abstract

Three new dolastane diterpenes (1–3) and five previously reported perhydroazulenes were isolated from the organic extracts of the brown alga Dilophus spiralis. The structure elucidation and the assignment of the relative configurations of the isolated natural products were based on extensive analyses of their spectroscopic data, whereas the absolute configuration of metabolite 2 was determined through its chemical conversion to a previously isolated compound of known configuration.

Published
2013
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2. Isolation and Structure Elucidation of Three New Dolastanes from the Brown Alga Dilophus spiralis.

Author

Ioannou, Efstathia, Vagias, Constantinos, and Roussis, Vassilios

Abstract

Three new dolastane diterpenes (1-3) and five previously reported perhydroazulenes were isolated from the organic extracts of the brown alga Dilophus spiralis. The structure elucidation and the assignment of the relative configurations of the isolated natural products were based on extensive analyses of their spectroscopic data, whereas the absolute configuration of metabolite 2 was determined through its chemical conversion to a previously isolated compound of known configuration. [ABSTRACT FROM AUTHOR]

Published
2013
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3. 2,6-Cyclo-xenicanes from the brown algae Dilophus fasciola and Dilophus spiralis

Author

Ioannou, Efstathia, Zervou, Maria, Ismail, Amel, Ktari, Leila, Vagias, Constantinos, and Roussis, Vassilios

Subjects
*DITERPENES, *BROWN algae, *FASCIOLA, *METABOLITES, *MOLECULAR structure, *NATURAL products, *NUCLEAR magnetic resonance spectroscopy, *MOLECULAR models
Abstract

Abstract: Seven new diterpenes, featuring the rare 2,6-cyclo-xenicane skeleton, along with eleven previously reported metabolites were isolated from the organic extracts of the brown algae Dilophus fasciola and Dilophus spiralis. The structure elucidation of the isolated natural products was based on detailed analyses of their spectroscopic data (NMR, MS, IR, UV), whereas the assignment of their relative configurations was assisted by molecular modelling studies. [Copyright &y& Elsevier]

Published
2009
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4. Dolastanes from the brown alga Dilophus spiralis: absolute stereochemistry and evaluation of cytotoxicity

Author

Ioannou, Efstathia, Quesada, Antonio, Vagias, Constantinos, and Roussis, Vassilios

Subjects
*OPTICAL polarization, *CHEMISTRY, *CELL lines, *OPTICAL diffraction
Abstract

Abstract: Five new dolastanes (1–5) were isolated from the brown alga Dilophus spiralis. The structural elucidation of the isolated compounds and the assignment of relative stereochemistry were based on analyses of their spectroscopic data. The structure proposed for 1 was confirmed by single crystal X-ray diffraction analysis, whereas its absolute stereochemistry was determined using the modified Mosher''s method. The cytotoxicity of 1–4 was evaluated against seven cell lines. [Copyright &y& Elsevier]

Published
2008
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5. Dilospiranes A and B: diterpenes featuring novel carbocyclic units from the brown alga Dilophus spiralis

Author

Ioannou, Efstathia, Vagias, Constantinos, and Roussis, Vassilios

Subjects
*DITERPENES, *CARBOCYCLIC acids, *BROWN algae, *MOLECULAR structure, *NATURAL products, *EXTRACTION (Chemistry), *SPECTRUM analysis
Abstract

Abstract: Dilospiranes A and B (1 and 2), two diterpenes featuring unprecedented carbocycles, were isolated from the organic extract of the brown alga Dilophus spiralis, collected from the coast of Elafonissos Island, Greece. The structures and the relative configurations of the isolated natural products were determined on the basis of extensive analyses of their spectroscopic data. [Copyright &y& Elsevier]

Published
2011
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6. Structures and Antibacterial Activities of Minor Dolabellanes from the Brown Alga Dilophus spiralis

Author

Simon Gibbons, Antonio Quesada, Vassilios Roussis, M. Mukhlesur Rahman, Constantinos Vagias, and Efstathia Ioannou

Subjects
Staphylococcus aureus, Stereochemistry, Chemistry, Mic values, Organic Chemistry, Absolute configuration, medicine, Biological activity, Physical and Theoretical Chemistry, medicine.disease_cause, Terpenoid, Dilophus spiralis
Abstract

Thirteen new minor diterpenes featuring the dolabellane skeleton (1-13) were isolated from the organic extracts of the brown alga Dilophus spiralis, collected in Elafonissos Island. The structures and relative configurations of the isolated natural products were elucidated on the basis of extensive analyses of their spectroscopic data (NMR, MS, IR). The absolute configuration of 1 was determined by using the modified Mosher's method, whereas the structure of 2 was confirmed by single-crystal X-ray diffraction analysis. The antibacterial activities of metabolites 1-9 and 13 were evaluated against six strains of Staphylococcus aureus, including multidrug- and methicillin-resistant variants. Compounds 1 and 4 exhibited noteworthy levels of activity with MIC values in the range of 2-8 μg/mL.

Published
2012
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8. New dolabellanes from the brown alga Dilophus spiralis

Author

M. Mukhlesur Rahman, Efstathia Ioannou, Constantinos Vagias, Simon Gibbons, and Vasilios Roussis

Subjects
Pharmacology, Complementary and alternative medicine, Chemical engineering, Organic Chemistry, Drug Discovery, Botany, Pharmaceutical Science, Molecular Medicine, Biology, Analytical Chemistry, Dilophus spiralis
Published
2008
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9. Seasonal variations in the production of antifungal substances by some dictyotales (brown algae) from the french mediterranean coast

Author

J. Moreau, D. Pesando, P. Bernard, J. C. Pionnat, and B. Caram

Subjects
Mediterranean climate, Antifungal, medicine.drug_class, Algal species, fungi, Dictyotales, Aquatic Science, Biology, biology.organism_classification, Dilophus spiralis, Brown algae, Algae, Botany, medicine, Dictyota dichotoma
Abstract

Hexane extracts of some algae belonging to the Dictyotales collected over a 12 month period were tested for their antifungal activity using human pathogenic fungi (yeasts, moulds and dermatophytes) and phytopathogenic fungi responsible for diseases in Mediterranean plants and trees. The three algal species tested (Dictyota dichotoma, Dictyota dichotoma var. implexa, Dilophus spiralis) exhibited a wide spectrum of antifungal activity which varied during the seasons.

Published
1988
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