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Introduction: Sexually transmitted infections (STI) are major public health problem of economically productive age group. Worldwide more cases of STI are seen among reproductive age group i.e., 15 to 49 years. World Health Organization estimates 340 million curable STIs each year. In India, 6% to 15% population is infected with one or more STIs. Hence, present study was conducted at STI clinic in suburban area. The objectives were to assess the socio-demographic factors, syndromes suffered and factors influencing treatment outcome among clients attending STI OPD. Methodology: 274 clients participated in the longitudinal study over a period of 6 months. Results: 232 female clients (84.7%) proved female preponderance at STI clinic. Around 194 cases (70.8%) belonged to the age group 25 to 44 years which is economically productive age group. Married females (92.24%) and unmarried males (59.5%) presented with STI syndromes. Among males, urethral discharge (66.67%) and among females, vaginal discharge (82.76%) were the predominating symptoms. The clients studied up to 10th standard, constituted 48.54% of the study sample. 53.28% of the clients belonged to upper lower socio-economic status. About 211 (90.9%) women were housewives. About 31 (73.8%) males were semi-skilled and skilled laborers. Conclusion: This study highlighted the vulnerability of females to STIs. The reproductive and economically productive age group forms major part of the affected population. The gap between the knowledge and application of correct and consistent use of condom needs to be reduced. Special emphasis on partner notification and their management will have an impact on prevention of STIs.

In the world cancer is the major cause of death. Adansonia digitata L is commonly called as baobab belongs to Family Bombacaceae. Due to the high cost and toxic side effects like Bone marrow suppression, hepatotoxicity, nephrotoxicity, Immunosuppression, teratogenicity etc. of chemotherapeutic agents. So, for the proper controlling on cancer the trends of people are moving towards natural therapies. In light to above, in present research A. digitata L is selected for evaluation of in-vitro anticancer activity based on its reported phytoconstituents of fruit and quantitation of active principle of it. The extracts of fruit pulp, seed, and its combination were obtained using solvents like water, ethanol and n-hexane by maceration technique (Aqueous) and Soxhlet extraction method (organic). This extracts were used for further research possesses phytochemical constituents like Carbohydrates, tannins, Saponins, vitamins, alkaloids, terpenoids, phenol, glycoside flavonoids, steroids, etc. in-vitro antioxidant activity were evaluated via free scavenging assay by using DPPH assay method. Further in-vitro anticancer activity was evaluated against three human cancer cell lines MCF-7 (breast cancer cell line), Hep-G2 (liver cancer cell line) and COLO-205 (colon cancer cell line) using Brine Shrimp Lethality Assay (BSLA), Tryphan Blue Dye Cell Exclusion Assay (TBDCEA) and MTT assay. The quantitation of active ingredients Vit. C and Squalene from extracts was done by using titration method and HPLC method respectively. Formulation possesses highest percent antioxidant capacity (49.36). In BSLA formulation possesses highest rate of percent mortality than other extracts. In TBCE assay and in MTT assay formulation gives more significant effect in Hep-G2 liver cancer cell line than remaining cell lines. These findings introduce A. digitata L as potentially useful as anti-cancer agent. Further research is required to elucidate its specific mechanism of action and exact active principle responsible for action.

A simple, rapid and reliable UV spectroscopic method was developed and validated for simultaneous estimation of Amlodipine besylate (Amlo) and Celecoxib (Celo) in pure and combined dosage form. Amlo and Celo shows absorption maximum in methanol at 237nm and 252nm respectively. According to ICH guidelines, this method was validated for linearity, precision, accuracy, limit of detection and Limit of quantitation. This method showed linearity and correlation coefficient for Amlo and Celo as 2 to 12μg/ml, 0.9981 and 0.9984 respectively. The recovery studies for Amlo and Celo was obtained to be 100.5 to 101.66% and 100.28% to 101% respectively. The precision of method were established by repeatability study. Limit of detection and Limit of quantitation are 0.21μg/ml and 0.64μg/ml for Amlo and 0.12μg/ml and 0.36μg/ml for Celo respectively. The statistical parameters and recovery data presented that the method may be engaged for efficient, rapid examination of both drugs the from tablet formulation. The percentage label claim present in formulation tablet was obtained to be 99% and 100.3% for Amlo and Celo respectively. These analysis is clearly specified that without there interference from excipients in the formulation.

This paper introduce new technique to help people when they need blood. Life care is the android based mobile application, which uses the Java language. This Android app will help patients who are in need of Blood it will give the patient address of nearest Blood Bank along with information regarding Blood Banks. This app not only will connect Blood Banks but also willing Donors. Pranali Dilip Kadam | Aniket Shivaji Vajire "Life-Care Online Blood Donor Finder Application using Android" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-3 , April 2018, URL: https://www.ijtsrd.com/papers/ijtsrd11546.pdf

The pandemic influenza A (H1N1) 2009 originated in Mexico and rapidly spread to the United States and many other countries. India reported the first pandemic influenza case in May 2009. Autopsy studies describing the pathology of pandemic influenza infection in humans have appeared in the literature and most of these were from Western countries. We present the clinicopathologic features in 46 fatal cases with confirmed pandemic influenza A (H1N1) 2009 virus infection during August 2009 to October 2010. Postmortem needle biopsy tissues were examined for histopathological changes and distribution of virus antigen by immunohistochemistry. The results are comparable with previous autopsy studies. Diffuse alveolar damage was the consistent finding in the lung tissues. However, underlying medical conditions were not noted in the cases from present study. Consistent presence of viral antigen was noted in the bronchiolar epithelium without any reference to the duration of illness. This study also emphasizes the use of the postmortem needle biopsy technique whenever an autopsy is not possible.

Human influenza virus pandemics constitute a major global public health issue. Although studies on autopsy specimens from the recent pandemic by the 2009 influenza A (H1N1) virus have revealed a broad spectrum of pathologic findings, direct electron microscopic studies of the lung tissue from influenza fatalities are few. In this study, we examined five well-preserved pulmonary necropsy specimens from fatal cases of laboratory-confirmed pH1N1 from India. The novel observations in comparison with earlier reports included direct imaging of influenza virus budding within dilated cisternae of pneumocytes, cell-free virus emerging from the cell membrane of a pneumocyte in the alveolar lumen, presence of polymorphonuclear cells with red blood cells as inflammatory exudates close to hyaline membranes and extensive cytoplasmic degeneration of epithelial cells of the alveolar lining. These observations are in consistent with the earlier findings and emphasize the possible role of this virus directly infecting cells of the lower respiratory tract as a key event in the rapid pathogenesis of pH1N1 disease process.

The pandemic influenza A (H1N1) 2009 originated in Mexico and rapidly spread to the United States and many other countries. India reported the first pandemic influenza case in May 2009. Autopsy studies describing the pathology of pandemic influenza infection in humans have appeared in the literature and most of these were from Western countries. We present the clinicopathologic features in 46 fatal cases with confirmed pandemic influenza A (H1N1) 2009 virus infection during August 2009 to October 2010. Postmortem needle biopsy tissues were examined for histopathological changes and distribution of virus antigen by immunohistochemistry. The results are comparable with previous autopsy studies. Diffuse alveolar damage was the consistent finding in the lung tissues. However, underlying medical conditions were not noted in the cases from present study. Consistent presence of viral antigen was noted in the bronchiolar epithelium without any reference to the duration of illness. This study also emphasizes the use of the postmortem needle biopsy technique whenever an autopsy is not possible.

Background Tendu (Diospyros melanoxylon RoxB.) leaf is widely used in India in the form of wrapper for making a crude smoking stick popularly known as ‘‘Beedi’’. Solapur city of Maharashtra state has large number of small beedi making units. Large quantity waste from these industries in the form of trimmed leaf residues is available as feed material for preparation of vermicompost. The present investigations were aimed to study effect of vermicompost prepared from such novel leaf residues as the tendu leaves on the growth and yield of Phaseolus vulgaris under greenhouse conditions. The seeds of French bean were sown in cement pots containing soil alone (control), soil with various concentrations of vermicompost alone, soil with various concentrations of urea only and different admixtures of vermicompost and urea. Results The study revealed that the seed germination, shoot and root length, shoot and root fresh weights, shoot and root dry weights, thousand grain weight and grain weight per plant increased significantly (p B 0.05) compared to control due to application of vermicompost when used at proper proportions. Thus, the growth and yield parameters were significantly (p B 0.05) greater in T2 (75 % N through vermicompost) than in T1 (100 % N through vermicompost) and T3 (50 % N through vermicompost). Many growth parameters of T1 were lower than those in the control indicating some deleterious effect of vermicompost at higher concentrations. The combined application of tendu leaf vermicompost and urea increased the growth and yield of Phaseolus vulgaris significantly (p B 0.05). The maximum grain yield was due to combined application of vermicompost at 25 % N through vermicompost plus 75 % N through urea. Conclusions The pot trial experiments suggested that the quantity of chemical fertilizer for French bean could be reduced by 25–50 % due to combined application of vermicompost and chemical fertilizer. However, application of tendu leaf vermicompost alone at higher concentrations may reduce growth parameters and yield of P. vulgaris.