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2. Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants
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Zhou, Bin, Rayner, Archie W, Gregg, Edward W, Sheffer, Kate E, Carrillo-Larco, Rodrigo M, Bennett, James E, Shaw, Jonathan E, Paciorek, Christopher J, Singleton, Rosie K, Barradas Pires, Ana, Stevens, Gretchen A, Danaei, Goodarz, Lhoste, Victor PF, Phelps, Nowell H, Heap, Rachel A, Jain, Lakshya, D'Ailhaud De Brisis, Yse, Galeazzi, Agnese, Kengne, Andre P, Mishra, Anu, Ikeda, Nayu, Lin, Hsien-Ho, Aguilar-Salinas, Carlos A, Anjana, Ranjit Mohan, Ben Romdhane, Habiba, Davletov, Kairat, Ganapathy, Shubash, Heidemann, Christin, Khader, Yousef Saleh, Khang, Young-Ho, Laxmaiah, Avula, Mbanya, Jean Claude N, Mohan, Viswanathan, Narayan, KM Venkat, Pavkov, Meda E, Sobngwi, Eugène, Wade, Alisha N, Younger-Coleman, Novie O, Zdrojewski, Tomasz, Abarca-Gómez, Leandra, Abbasi-Kangevari, Mohsen, Abdul Rahim, Hanan F, Abu-Rmeileh, Niveen M, Adambekov, Shalkar, Adams, Robert J, Aekplakorn, Wichai, Afzal, Shoaib, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Agyemang, Charles, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmadi, Nastaran, Ahmed, Soheir H, Ahrens, Wolfgang, Ajlouni, Kamel, Al-Hamli, Sarah F, Al-Hinai, Halima, Al-Lawati, Jawad A, Al Asfoor, Deena, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Ali, Mohamed M, Ali, Mohammed K, Alieva, Anna V, Alinezhad, Farbod, Alkandari, Abdullah, Alkerwi, Ala'a, Aly, Eman, Amarapurkar, Deepak N, Andersen, Lars Bo, Anderssen, Sigmund A, Andrade, Dolores S, Ansari-Moghaddam, Alireza, Aounallah-Skhiri, Hajer, Araújo, Joana, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Aspelund, Thor, Assah, Felix K, Assembekov, Batyrbek, Au Yeung, Shiu Lun, Auvinen, Juha, Avdičová, Mária, Azad, Kishwar, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Bacopoulou, Flora, Balakrishna, Nagalla, Balanova, Yulia, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, José R, Barbagallo, Carlo M, Barcelo, Alberto, Baretić, Maja, Barrera, Lena, Barreto, Marta, Basit, Abdul, Batieha, Anwar M, Batista, Aline P, Baur, Louise A, Belavendra, Antonisamy, Benedek, Theodora, Benet, Mikhail, Benzeval, Michaela, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Berrios Carrasola, Ximena, Bettiol, Heloísa, Beybey, Augustin F, Bhargava, Santosh K, Bi, Yufang, Bika Lele, Elysée Claude, Bikbov, Mukharram M, Bista, Bihungum, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Björkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Bobak, Martin, Boehm, Bernhard O, Boggia, Jose G, Boissonnet, Carlos P, Bojesen, Stig E, Bonaccio, Marialaura, Bonilla-Vargas, Alice, Borghs, Herman, Botomba, Steve, Bovet, Pascal, Brajkovich, Imperia, Brenner, Hermann, Brewster, Lizzy M, Brian, Garry R, Briceño, Yajaira, Brito, Miguel, Bueno, Gloria, Bugge, Anna, Buntinx, Frank, Cabrera de León, Antonio, Caixeta, Roberta B, Can, Günay, Cândido, Ana Paula C, Capanzana, Mario V, Čapková, Naděžda, Capuano, Eduardo, Capuano, Rocco, Capuano, Vincenzo, Cardoso, Viviane C, Carlsson, Axel C, Casanueva, Felipe F, Censi, Laura, Cervantes–Loaiza, Marvin, Chadjigeorgiou, Charalambos A, Chamnan, Parinya, Chamukuttan, Snehalatha, Chan, Queenie, Charchar, Fadi J, Chaturvedi, Nish, Chen, Chien-Jen, Chen, Huashuai, Chen, Long-Sheng, Cheng, Ching-Yu, Cheraghian, Bahman, Chetrit, Angela, Chiou, Shu-Ti, Chirlaque, María-Dolores, Chudek, Jerzy, Cifkova, Renata, Cirillo, Massimo, Claessens, Frank, Clarke, Janine, Cohen, Emmanuel, Concin, Hans, Cooper, Cyrus, Cosmin, Cojocaru R, Costanzo, Simona, Cowan, Melanie J, Cowell, Chris, Crampin, Amelia C, Crujeiras, Ana B, Cruz, Juan J, Cureau, Felipe V, Cuschieri, Sarah, D'Arrigo, Graziella, d'Orsi, Eleonora, da Silva-Ferreira, Haroldo, Dallongeville, Jean, Damasceno, Albertino, Dankner, Rachel, Dastgiri, Saeed, Dauchet, Luc, De Curtis, Amalia, de Gaetano, Giovanni, De Henauw, Stefaan, De Ridder, David, Deepa, Mohan, DeGennaro, Vincent Jr, Demarest, Stefaan, Dennison, Elaine, Deschamps, Valérie, Dhimal, Meghnath, Dika, Zivka, Djalalinia, Shirin, Donfrancesco, Chiara, Dorobantu, Maria, Dragano, Nico, Drygas, Wojciech, Du, Shufa, Du, Yong, Duante, Charmaine A, Duboz, Priscilla, Duda, Rosemary B, Dushpanova, Anar, Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Ebrahimi, Narges, Eddie, Ricky, Eftekhar, Ebrahim, Efthymiou, Vasiliki, Egbagbe, Eruke E, Eggertsen, Robert, Eghtesad, Sareh, Ejembi, Clara Ladi, El-Khateeb, Mohammad, El Ati, Jalila, Eldemire-Shearer, Denise, Elosua, Roberto, Enang, Ofem, Erasmus, Rajiv T, Erem, Cihangir, Ergor, Gul, Eriksen, Louise, Eriksson, Johan G, Esmaeili, Ali, Evans, Roger G, Fagherazzi, Guy, Fahimfar, Noushin, Fakhradiyev, Ildar, Fakhretdinova, Albina A, Fall, Caroline H, Faramarzi, Elnaz, Farjam, Mojtaba, Farzadfar, Farshad, Farzi, Yosef, Fattahi, Mohammad Reza, Fawwad, Asher, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernández-Bergés, Daniel, Fernando, Desha R, Ferrao, Thomas, Ferrari, Marika, Ferrario, Marco M, Ferreccio, Catterina, Ferrer, Eldridge, Feskens, Edith JM, Fink, Günther, Flood, David, Forsner, Maria, Fosse-Edorh, Sandrine, Fottrell, Edward F, Fouad, Heba M, Francis, Damian K, Frontera, Guillermo, Fujiati, Isti I, Fumihiko, Matsuda, Furusawa, Takuro, Gaciong, Zbigniew, Galvano, Fabio, Garnett, Sarah P, Gaspoz, Jean-Michel, Gasull, Magda, Gazzinelli, Andrea, Gehring, Ulrike, Ghaderi, Ebrahim, Ghamari, Seyyed-Hadi, Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Ghimire, Anup, Gialluisi, Alessandro, Giampaoli, Simona, Gianfagna, Francesco, Gill, Tiffany K, Giovannelli, Jonathan, Gironella, Glen, Giwercman, Aleksander, Goldberg, Marcel, Goltzman, David, Gomula, Aleksandra, Gonçalves, Helen, Gonçalves, Mauer, Gonzalez-Chica, David A, Gonzalez-Gross, Marcela, González-Rivas, Juan P, Gonzalez, Angel R, Goto, Atsushi, Gottrand, Frederic, Grafnetter, Dušan, Grammatikopoulou, Maria G, Grant, Andriene, Grimsgaard, Anne Sameline, Grodzicki, Tomasz, Grøntved, Anders, Grosso, Giuseppe, Gu, Dongfeng, Gudnason, Vilmundur, Guerrero, Ramiro, Guessous, Idris, Gujral, Unjali P, Gupta, Rajeev, Gutierrez, Laura, Gwee, Xinyi, Ha, Seongjun, Haghshenas, Rosa, Hakimi, Hamid, Hambleton, Ian R, Hamzeh, Behrooz, Hange, Dominique, Hantunen, Sari, Hao, Jie, Harooni, Javad, Hashemi-Shahri, Seyed Mohammad, Hata, Jun, Hayes, Alison J, He, Jiang, Henrique, Rafael dos Santos, Henriques, Ana, Herrala, Sauli, Herzig, Karl-Heinz, Heshmat, Ramin, Hill, Allan G, Ho, Sai Yin, Holdsworth, Michelle, Homayounfar, Reza, Hopman, Wilma M, Horimoto, Andrea RVR, Hormiga, Claudia, Horta, Bernardo L, Houti, Leila, Howitt, Christina, Htay, Thein Thein, Htet, Aung Soe, Htike, Maung Maung Than, Huerta, José María, Huhtaniemi, Ilpo Tapani, Huiart, Laetitia, Huisman, Martijn, Hunsberger, Monica, Husseini, Abdullatif, Huybrechts, Inge, Iacoviello, Licia, Iakupova, Ellina M, Iannone, Anna G, Ibrahim Wong, Norazizah, Ijoma, Chinwuba, Irazola, Vilma E, Ishida, Takafumi, Islam, Sheikh Mohammed Shariful, Islek, Duygu, Ittermann, Till, Iwasaki, Masanori, Jääskeläinen, Tuija, Jacobs, Jeremy M, Jaddou, Hashem Y, Jadoul, Michel, Jallow, Bakary, James, Kenneth, Jamil, Kazi M, Janus, Edward, Jarvelin, Marjo-Riitta, Jasienska, Grazyna, Jelaković, Ana, Jelaković, Bojan, Jennings, Garry, Jha, Anjani Kumar, Jibo, AM, Jimenez, Ramon O, Jöckel, Karl-Heinz, Jokelainen, Jari J, Jonas, Jost B, Josipović, Josipa, Joukar, Farahnaz, Jóźwiak, Jacek, Kafatos, Anthony, Kajantie, Eero O, Kalmatayeva, Zhanna, Kalter-Leibovici, Ofra, Karakosta, Argyro, Karki, Khem B, Katibeh, Marzieh, Katulanda, Prasad, Kauhanen, Jussi, Kazakbaeva, Gyulli M, Kaze, François F, Ke, Calvin, Keinänen-Kiukaanniemi, Sirkka, Kelishadi, Roya, Keramati, Maryam, Kersting, Mathilde, Khalagi, Kazem, Khaledifar, Arsalan, Khalili, Davood, Kheiri, Bahareh, Kheradmand, Motahareh, Khosravi Farsani, Alireza, Kiechl-Kohlendorfer, Ursula, Kiechl, Sophia J, Kiechl, Stefan, Kim, Hyeon Chang, Kingston, Andrew, Klakk, Heidi, Klanova, Jana, Knoflach, Michael, Kolsteren, Patrick, König, Jürgen, Korpelainen, Raija, Korrovits, Paul, Kos, Jelena, Koskinen, Seppo, Kowlessur, Sudhir, Koziel, Slawomir, Kratzer, Wolfgang, Kriemler, Susi, Kristensen, Peter Lund, Krokstad, Steinar, Kromhout, Daan, Kubinova, Ruzena, Kujala, Urho M, Kulimbet, Mukhtar, Kulothungan, Vaitheeswaran, Kumari, Meena, Kutsenko, Vladimir, Kyobutungi, Catherine, La, Quang Ngoc, Laatikainen, Tiina, Labadarios, Demetre, Lachat, Carl, Laid, Youcef, Lall, Lachmie, Langsted, Anne, Lankila, Tiina, Lanska, Vera, Lappas, Georg, Larijani, Bagher, Latt, Tint Swe, Laurenzi, Martino, Le Coroller, Gwenaëlle, Lee, Jeannette, Lehtimäki, Terho, Lemogoum, Daniel, Leung, Gabriel M, Lim, Charlie, Lim, Wei-Yen, Lima-Costa, M Fernanda, Lin, Yi-Jing, Lind, Lars, Lissner, Lauren, Liu, Liping, Liu, Xiaotian, Lo, Wei-Cheng, Loit, Helle-Mai, Lopez-Garcia, Esther, Lopez, Tania, Lozano, José Eugenio, Luksiene, Dalia, Lundqvist, Annamari, Lunet, Nuno, Lung, Thomas, Lustigová, Michala, Ma, Guansheng, Machado-Coelho, George LL, Machado-Rodrigues, Aristides M, Macia, Enguerran, Macieira, Luisa M, Madar, Ahmed A, Maestre, Gladys E, Maggi, Stefania, Magliano, Dianna J, Magriplis, Emmanuella, Mahasampath, Gowri, Maire, Bernard, Makdisse, Marcia, Makrilakis, Konstantinos, Malekpour, Mohammad-Reza, Malekzadeh, Fatemeh, Malekzadeh, Reza, Malyutina, Sofia, Maniego, Lynell V, Manios, Yannis, Mansour-Ghanaei, Fariborz, Manzato, Enzo, Mapatano, Mala Ali, Marcil, Anie, Mardones, Francisco, Margozzini, Paula, Marques-Vidal, Pedro, Marques, Larissa Pruner, Martorell, Reynaldo, Mascarenhas, Luis P, Masimango Imani, Mannix, Masinaei, Masoud, Masoodi, Shariq R, Mathiesen, Ellisiv B, Mathur, Prashant, Matsha, Tandi E, Mc Donald Posso, Anselmo J, McFarlane, Shelly R, McGarvey, Stephen T, McLean, Scott B, McNulty, Breige A, Mediene Benchekor, Sounnia, Mehlig, Kirsten, Mehrparvar, Amir Houshang, Melgarejo, Jesus D, Méndez, Fabián, Menezes, Ana Maria B, Mereke, Alibek, Meshram, Indrapal I, Meto, Diane T, Michels, Nathalie, Minderico, Cláudia S, Mini, GK, Miquel, Juan Francisco, Miranda, J Jaime, Mirjalili, Mohammad Reza, Mirkopoulou, Daphne, Modesti, Pietro A, Moghaddam, Sahar Saeedi, Mohammad, Kazem, Mohammadi, Mohammad Reza, Mohammadi, Zahra, Mohammadifard, Noushin, Mohammadpourhodki, Reza, Mohd Yusoff, Muhammad Fadhli, Mohebbi, Iraj, Møller, Niels C, Molnár, Dénes, Momenan, Amirabbas, Montenegro Mendoza, Roger A, Moosazadeh, Mahmood, Moradpour, Farhad, Morejon, Alain, Moreno, Luis A, Morgan, Karen, Morin, Suzanne N, Moschonis, George, Moslem, Alireza, Mosquera, Mildrey, Mossakowska, Malgorzata, Mostafa, Aya, Mostafavi, Seyed-Ali, Mota, Eugen, Mota, Jorge, Mota, Maria, Motlagh, Mohammad Esmaeel, Motta, Jorge, Msyamboza, Kelias P, Mu, Thet Thet, Muiesan, Maria L, Munroe, Patricia B, Mursu, Jaakko, Musa, Kamarul Imran, Mustafa, Norlaila, Muyer, Muel Telo MC, Nabipour, Iraj, Nagel, Gabriele, Naidu, Balkish M, Najafi, Farid, Námešná, Jana, Nang, Ei Ei K, Nangia, Vinay B, Naseri, Take, Navarro-Ramírez, Ana J, Neelapaichit, Nareemarn, Nejatizadeh, Azim, Nenko, Ilona, Nervi, Flavio, Ng, Tze Pin, Nguyen, Chung T, Nguyen, Nguyen D, Nguyen, Quang Ngoc, Ni, Michael Y, Nie, Peng, Nieto-Martínez, Ramfis E, Ning, Guang, Ninomiya, Toshiharu, Nishi, Nobuo, Noale, Marianna, Noboa, Oscar A, Noda, Mitsuhiko, Nordestgaard, Børge G, Noto, Davide, Nsour, Mohannad Al, Nuhoğlu, Irfan, Nyirenda, Moffat, O'Neill, Terence W, Oh, Kyungwon, Ohtsuka, Ryutaro, Omar, Mohd Azahadi, Onat, Altan, Ong, Sok King, Onodugo, Obinna, Ordunez, Pedro, Ornelas, Rui, Ortiz, Pedro J, Osmond, Clive, Ostovar, Afshin, Otero, Johanna A, Ottendahl, Charlotte B, Otu, Akaninyene, Owusu-Dabo, Ellis, Pahomova, Elena, Palmieri, Luigi, Pan, Wen-Harn, Panagiotakos, Demosthenes, Panda-Jonas, Songhomitra, Pang, Zengchang, Panza, Francesco, Paoli, Mariela, Park, Suyeon, Parsaeian, Mahboubeh, Patalen, Chona F, Patel, Nikhil D, Pechlaner, Raimund, Pećin, Ivan, Pedro, João M, Peixoto, Sergio Viana, Peltonen, Markku, Pereira, Alexandre C, Pessôa dos Prazeres, Thaliane Mayara, Peykari, Niloofar, Phall, Modou Cheyassin, Pham, Son Thai, Pichardo, Rafael N, Pigeot, Iris, Pikhart, Hynek, Pilav, Aida, Piler, Pavel, Pitakaka, Freda, Piwonska, Aleksandra, Pizarro, Andreia N, Plans-Rubió, Pedro, Plata, Silvia, Popkin, Barry M, Porta, Miquel, Poudyal, Anil, Pourfarzi, Farhad, Pourshams, Akram, Poustchi, Hossein, Prabhakaran, Dorairaj, Pradeepa, Rajendra, Price, Alison J, Price, Jacqueline F, Providencia, Rui, Puder, Jardena J, Puhakka, Soile, Punab, Margus, Qiao, Qing, Qorbani, Mostafa, Quintana, Hedley K, Quoc Bao, Tran, Radisauskas, Ricardas, Rahimikazerooni, Salar, Raitakari, Olli, Ramachandran, Ambady, Ramirez-Zea, Manuel, Ramke, Jacqueline, Ramos, Elisabete, Ramos, Rafel, Rampal, Lekhraj, Rampal, Sanjay, Ramsay, Sheena E, Rangel Reina, Daniel A, Rannan-Eliya, Ravindra P, Rashidi, Mohammad-Mahdi, Redon, Josep, Renner, Jane DP, Reuter, Cézane P, Revilla, Luis, Rezaei, Negar, Rezaianzadeh, Abbas, Rho, Yeunsook, Rigo, Fernando, Riley, Leanne M, Risérus, Ulf, Roa, Reina G, Robinson, Louise, Rodríguez-Anderson, Wendy E, Rodríguez-Artalejo, Fernando, Rodriguez-Perez, María del Cristo, Rodríguez-Villamizar, Laura A, Rodríguez, Andrea Y, Roggenbuck, Ulla, Rohloff, Peter, Rojas-Martinez, Rosalba, Romeo, Elisabetta L, Rosengren, Annika, Roy, Joel GR, Rubinstein, Adolfo, Ruiz-Castell, Maria, Russo, Paola, Rust, Petra, Rutkowski, Marcin, Sabanayagam, Charumathi, Sabbaghi, Hamideh, Sachdev, Harshpal S, Sadjadi, Alireza, Safarpour, Ali Reza, Safi, Sare, Safiri, Saeid, Saghi, Mohammad Hossien, Saidi, Olfa, Sakata, Satoko, Saki, Nader, Šalaj, Sanja, Salanave, Benoit, Salonen, Jukka T, Salvetti, Massimo, Sánchez-Abanto, Jose, Santos, Diana A, Santos, Lèlita C, Santos, Maria Paula, Santos, Rute, Santos, Tamara R, Saramies, Jouko L, Sardinha, Luis B, Sarrafzadegan, Nizal, Sato, Yoko, Saum, Kai-Uwe, Savin, Stefan, Sawada, Norie, Sbaraini, Mariana, Scazufca, Marcia, Schaan, Beatriz D, Schargrodsky, Herman, Scheidt-Nave, Christa, Schipf, Sabine, Schmidt, Amand Floriaan, Schmidt, Börge, Schmidt, Carsten O, Schnohr, Peter, Schooling, Catherine Mary, Schöttker, Ben, Schramm, Sara, Sebert, Sylvain, Sedaghattalab, Moslem, Sein, Aye Aye, Sen, Abhijit, Sepanlou, Sadaf G, Servais, Jennifer, Sewpaul, Ronel, Shalnova, Svetlana, Shamshirgaran, Seyed Morteza, Shanthirani, Coimbatore Subramaniam, Sharafkhah, Maryam, Sharma, Sanjib K, Sharman, Almaz, Shayanrad, Amaneh, Shayesteh, Ali Akbar, Shibuya, Kenji, Shimizu-Furusawa, Hana, Shiri, Rahman, Shoranov, Marat, Shrestha, Namuna, Si-Ramlee, Khairil, Siani, Alfonso, Siedner, Mark J, Silva, Diego Augusto Santos, Sim, Xueling, Simon, Mary, Simons, Judith, Simons, Leon A, Sjöström, Michael, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemysław, Smeeth, Liam, Söderberg, Stefan, Soemantri, Agustinus, Solfrizzi, Vincenzo, Somi, Mohammad Hossein, Soumaré, Aïcha, Sousa-Poza, Alfonso, Sousa-Uva, Mafalda, Sparrenberger, Karen, Staessen, Jan A, Stang, Andreas, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D, Stessman, Jochanan, Stokwiszewski, Jakub, Stronks, Karien, Suarez-Ortegón, Milton F, Suebsamran, Phalakorn, Suka, Machi, Sun, Chien-An, Sun, Jianping, Sundström, Johan, Suriyawongpaisal, Paibul, Sylva, René Charles, Tai, E Shyong, Takuro, Furusawa, Tamosiunas, Abdonas, Tan, Eng Joo, Tanabayev, Baimakhan, Tandon, Nikhil, Tarawneh, Mohammed Rasoul, Tarqui-Mamani, Carolina B, Taylor, Anne, Tello, Tania, Tham, Yih Chung, Thankappan, KR, Theobald, Holger, Theodoridis, Xenophon, Thomas, Nihal, Thrift, Amanda G, Timmermans, Erik J, Tolonen, Hanna K, Tolstrup, Janne S, Tomaszewski, Maciej, Topbas, Murat, Tornaritis, Michael J, Torrent, Maties, Torres-Collado, Laura, Touloumi, Giota, Traissac, Pierre, Triantafyllou, Areti, Trinh, Oanh TH, Tsao, Yu-Hsiang, Tsiampalis, Thomas, Tsugane, Shoichiro, Tuitele, John, Tuliakova, Azaliia M, Tulloch-Reid, Marshall K, Tuomainen, Tomi-Pekka, Turley, Maria L, Tzala, Evangelia, Tzourio, Christophe, Ueda, Peter, Ugel, Eunice, Ukoli, Flora AM, Ulmer, Hanno, Uusitalo, Hannu MT, Valdivia, Gonzalo, Valvi, Damaskini, van Dam, Rob M, van den Born, Bert-Jan, Van der Heyden, Johan, Van Minh, Hoang, van Rossem, Lenie, Van Schoor, Natasja M, van Valkengoed, Irene GM, Vanderschueren, Dirk, Vanuzzo, Diego, Varbo, Anette, Vasan, Senthil K, Vega, Tomas, Veidebaum, Toomas, Velasquez-Melendez, Gustavo, Verdot, Charlotte, Veronesi, Giovanni, Verstraeten, Roosmarijn, Victora, Cesar G, Viet, Lucie, Villarroel, Luis, Vioque, Jesus, Virtanen, Jyrki K, Viswanathan, Bharathi, Vollenweider, Peter, Voutilainen, Ari, Vrijheid, Martine, Walton, Janette, Wan Bebakar, Wan Mohamad, Wan Mohamud, Wan Nazaimoon, Wang, Chongjian, Wang, Huijun, Wang, Ningli, Wang, Qian, Wang, Weiqing, Wang, Ya Xing, Wang, Yi-Ren, Wang, Ying-Wei, Wannamethee, S Goya, Webster-Kerr, Karen, Wedderkopp, Niels, Wei, Wenbin, Westbury, Leo D, Whincup, Peter H, Widhalm, Kurt, Widyahening, Indah S, Więcek, Andrzej, Wijemunige, Nilmini, Wilks, Rainford J, Willeit, Karin, Willeit, Peter, Wilsgaard, Tom, Wojtyniak, Bogdan, Wong-McClure, Roy A, Wong, Andrew, Wong, Emily B, Woodward, Mark, Wu, Chao-Chun, Wu, Frederick C, Xu, Haiquan, Xu, Liang, Xu, Yu, Yaacob, Nor Azwany, Yan, Li, Yan, Weili, Yasuharu, Tabara, Yeh, Chao-Yu, Yoosefi, Moein, Yoshihara, Akihiro, You, San-Lin, Yu, Yu-Ling, Yusoff, Ahmad Faudzi, Zainuddin, Ahmad A, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Zargar, Abdul Hamid, Zaw, Ko Ko, Zeljkovic Vrkic, Tajana, Zeng, Yi, Zhang, Bing, Zhang, Lei, Zhang, Luxia, Zhang, Zhen-Yu, Zhao, Ming-Hui, Zhao, Wenhua, Zholdin, Bekbolat, Zimmet, Paul, Zins, Marie, Zitt, Emanuel, Zoghlami, Nada, Zuñiga Cisneros, Julio, and Ezzati, Majid
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- 2024
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3. General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants
- Author
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Zhou, Bin, Bennett, James E, Wickham, Aidan P, Singleton, Rosie K, Mishra, Anu, Carrillo-Larco, Rodrigo M, Ikeda, Nayu, Jain, Lakshya, Barradas-Pires, Ana, Heap, Rachel A, Lhoste, Victor PF, Sheffer, Kate E, Phelps, Nowell H, Rayner, Archie W, Gregg, Edward W, Woodward, Mark, Stevens, Gretchen A, Iurilli, Maria LC, Danaei, Goodarz, Di Cesare, Mariachiara, Aguilar-Salinas, Carlos A, Ahmad, Noor Ani, Bovet, Pascal, Chen, Zhengming, Damasceno, Albertino, Filippi, Sarah L, Janszky, Imre, Kengne, Andre P, Khang, Young-Ho, Khunti, Kamlesh, Laxmaiah, Avula, Lim, Lee-Ling, Lissner, Lauren, Margozzini, Paula, Mbanya, Jean Claude N, McGarvey, Stephen T, Shaw, Jonathan E, Söderberg, Stefan, Soto-Mota, Luis Adrián, Wang, Junyang, Zaccardi, Francesco, Abarca-Gómez, Leandra, Abbasi-Kangevari, Mohsen, Abdrakhmanova, Shynar, Abdul Ghaffar, Suhaila, Abdul Rahim, Hanan F, Abdurrahmonova, Zulfiya, Abu-Rmeileh, Niveen M, Acosta-Cazares, Benjamin, Adam, Ishag, Adamczyk, Marzena, Aekplakorn, Wichai, 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4. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
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5. Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial
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Abbasciano, Isabella, Abrantes, Catarina, Accarino, Simone, Adler, Sharon, Adoberg, Annika, Afsari, Rouzbeh, Ahmad, Syeda, Ahmed, Jafar, Ahn, Wooin, Ajayi, Bamidele, Aksamit, Dariusz, Al Chalabi, Saif, Alamartine, Eric, Alchi, Bassam, Ali, Mohammad, Aliotta, Roberta, Almaani, Salem, Almeida, Catarina, Almeida, Edgar, Alvarez, Francisco de la Prada, Alves, Patricia, Annese, Francesca, Appel, Gerald, Arduan, Alberto Ortiz, Arena, Maria, Arevalo, Marta Calvo, Arfaania, Dariush, Arias, Carlos, Aristoy, Emma Calatayud, Asakiene, Egle, Ashley, Sarah, Assefi, Ali, Atenza, Alba, Auerbach, Asta, Augustyniak-Bartosik, Hanna, Avella, Monroy, Ayling-Smith, Jonathan, Ayoub, Isabelle, Ayvazyan, Christine, Baccaro, Rocco, Bailey, Asha, Baker, Bruce, Balamuthusamy, Saravanan, Ballarin, Jose, Barata, Rui, Barbic, Jerko, Barisic, Dunja, Barratt, Jonathan, Barreto, Jose Carlos de Jesus, Barrios, Clara, Belingheri, Mirco, Benesova, Anna, Bernabeu, Ana Avila, Bernhardt, Wanja, Bhadra, Shamik, Biancone, Luigi, Blanchard, Anne, Boaglio, Elena, Bolignano, Davide, Bomback, Andrew, Bonilla, Gustavo Andres Useche, Bordoli, Monica, Bose, Bhadran, Boudville, Neil, Brandon, Donald, Brown, Karen, Broyet, Christian, Bucknall, Thomas, Buffet, Alexandre, Bumblyte', Inga Arune, Burdese, Manuel, Burgos, Natalia Allende, Burguet, Laure, Burtey, Stephane, Busch, Martin, Cakiroglu, Figen, Campbell, Victoria, Canetta, Pietro, Capaccio, Flavia, Carbonell, Juan, Cardoso, Filipa, Carro, Clara Garcia, Carroll, Robert, Carron, Pierre-Louis, Carullo, Nazareno, Cassia, Matthias, Caster, Dawn, Castillo, Belen Vizcaino, Catucci, Davide, Cavalli, Andrea, Chae, Dong-Wan, Chakera, Aron, Chan, Doris, Chan, Gary Chi Wang, Chan, Anthony Ting Pong, Chan, Lai Wan, Chang, Jae Hyun, Chang, Ming-Shan, Chapman, Fiona, Charytan, Chaim, Chaudhry, Asghar, Cheetham, Melissa, Chen, Cheng-Hsu, Chen, Hsin-Yu, Chen, Chien-Liang, Chen, Hung-Yuan, Chen, Hung-Chun, Chenine, Leila, Cheung, Siu Fai, Cheung, Chee Kay, Chiche-Jourde, Noemie, Chiu, Hsien-Fu, Chiu, Yen-Ling, Chiu, Yi-Wen, Chiu, Ian, Choi, Hoon Young, Chou, Kang-Ju, Chowdhury, Paramit, Chowdhury, Pradip, Chrysochou, Constantina, Chukwu, Chukwuma, Chun, Ka Yeong, Chung, Wookyung, Cieniawski, Dominik, Claisse, Guillaume, Clayton, Philip, Cleary, Catalina Martín, Clement, Nisha, Coates, Toby, Cogno, Chiara, Colla, Loredana, Collins, Michael, Colucci, Marco, Combe, Christian, Comi, Nicolino, Comunale, Roderick, Contreras, Gabriel, Cooper, Bruce, Coppock, Gaia, Costa, Ana Cortesão, Costanzi, Stefano, Cozzolino, Mario, Crail, Susan, Cunha, Liliana, Curry, Elizabeth, Dai, Tiane, Daina, Erica, Daneshvari, Sam, Dasgupta, Indranil, DaSilva, Louise, Davidson, Robert, De Bhailis, Aine Maire, de Précigout, Valérie, Decupere, Marc, Delmas, Yahsou, Deodato, Francesca, Dhaun, Neeraj, Dhaygude, Ajay, Dhelaria, Ranjit, Di Maio, Federica, Diezhandino, Maria Angeles Goicoechea, Dika, Zivka, Dinic, Miriana, Dittmer, Ian, Dobre, Mirela, Doctor, Gabriel, Donati, Gabriele, Doubel, Peter, Douthit, Nicole, Draganova, Diliana, Drexler, Yelena, Drinkovic, Martin, Drinovska, Klara, Dudreuilh, Caroline, Dumond, Clement, Durlen, Ivan, Dussol, Bertrand, Encarnacion, Montserrat Diaz, Endre, Zoltan, Enrique, Jorge, Eqbal, Yusuf, Erlich, Jonathan, Esposito, Vittoria, Esposito, Ciro, Fakih, Faisal, Fang, Hua-Chang, Farinha, Ana, Fearday, Aaron, Felgueiras, Joana de Sousa Soares, Felicjanczuk, Elzbieta, Fernandes, João Carlos, Fernandes, Sara, Fernandes, Adriana, Fernandez, Jose Luño, Fernandez, Victor, Fernando, Mangalee, Figueiredo, Ana Carolina, Firre, Eric, Floege, Jürgen, Flossmann, Oliver, Floyd, Lauren, Fonseca, Nuno, Fonseca, Jose Nuno de Almeida Agapito, Foote, Celine, Forbes, Suzanne, Forcen, Angel, Fornoni, Alessia, Fouassier, David, Fraser, Ian, Fung, Ka Shun Samuel, Furlano, Monica, Furtado, Teresa, Gadh, Rajdeep, Gaisset, Roxane, Gallagher, Martin, Gameiro, Joana, Gangadharan, Muralikrishna, Garcia, Fabiola Alonso, Garcia, Olga Gracia, Garg, Gunjan, Garrouste, Cyril, Gautam, Archana, Geara, Abdallah, Geddes, Colin, Gellineo, Lana, Germain, Michael, Gesualdo, Loreto, Ghalli, Farid, Giaroni, Francesco, Giles, Harold, Gillies, Alastair, Gimeno, Ana Vilar, Girardet, Annette, Glaze, Jeffrey, Goh, Tze, Gois, Mario, Goldsmith, Christopher, Goma, Elena, Gomes, Ana Marta, Goncalves, Luis Pedro Falcao, Goncalves, Sara, Gontarek-Kacprzak, Julita, Gonzalez, Carlos, Gopu, Arun, Gowda, Nayan, Gray, Nicholas, Greco, Barbara, Green, Heather, Greze, Clarisse, Griffin, Sian, Guldris, Secundino Cigarran, Guzman, Ursula Verdalles, Ha, Jeffrey Tsun Kit, Hall, Amanda, Hamilton, Patrick, Han, Seung Hyeok, Haws, Robert, Hayat, Ashik, Heath, Lauren, Heinrichs, Sven, Henderson, Andrew, Henderson, Amy, Hendren, Elizabeth, Heng, Anne-Elisabeth, Heres, Salia Virxinia Pol, Herfurth, Johann Konstantin, Herrero, Evangelina Merida, Ho, Tzung-Yo, Hogan, Jonathan, Hohenstein, Bernd, Hollett, Peter, Horvatic, Ivica, Hsu, Bang-Gee, Hsu, Chia-Tien, Hsu, Chih-Yang, Hsu, Shih-Ping, Huang, Chien-Wei, Hudson, Amy, Hung, Chi-Chih, Hwang, Shang-Jyh, Hwang, Daw-Yang, Hyun, Young Youl, Ilmoja, Madis, Irish, Georgina, Jacob, Radu, Jahan, Sadia, Jain, Arunima, Jamar, Sofie, Jander, Anna, Jang, Hye Ryoun, Janko, Catherine, Jardine, Meg, Jaskowski, Piotr, Jeantet, Guillaume, Jelakovic, Bojan, Jeon, Junseok, Jeong, Jong Cheol, Jesudason, Shilpanjali, Jittirat, Arksarapuk, Jo, Sang-Kyung, Jones, Rachel, Joo, Narae, Jorge, Sofia, Julian, Bruce, Jung, JiYong, Jyothinagaram, Praveena, Kadakia, Jigar, Kamal, Fahameedah, Kanigicherla, Durga, Karanovic, Sandra, Karras, Alexandre, Kasimatis, Theodoros, Kassem, Mohamad, Kattamanchi, Siddhartha, Keller, Christopher, Kentric, Dubravka Trajbar, Kettner, Christiane, Khalil, Kassem, Kim, Dana, Kim, Se Joong, Kim, Yeong Hoon, Kim, Yunmi, Kim, Hyung Wook, Kim, Sunggyun, Kim, Jwa-Kyung, Kim, Aejin, Kim, Myung-Gyu, Kimber, Cassandra, Klamm, Kathryn, Koch, Annegret, Koester, Eric, Kolvald, Kulli, Kon, Sui, Kooienga, Laura Ann, Kotwal, Sradha, Krajewska, Magdalena, Kratka, Karolina, Krishnan, Anoushka, Krishnasamy, Rathika, Krueger, Thilo, Kruljac, Ivan, Kulka, Simone, Kunzendorf, Ulrich, Kuo, Mei-Chuan, Kuo, Hung-Tien, Kuo, Sheng, Kwan, Lorraine Pui Yuen, Kwella, Norbert, Kwella, Bogna, Kyaw, Kay, Labat, Aurore, Lafayette, Richard, Lagatta, Mark, Lam, Chi Kwan Darwin, Lambie, Mark, Lanaret, Camille, Latif, Farah, Laute, Margo, Law, Wai Ping, Lawman, Sarah, Lazo, Mercedes Salgueira, Lee, Hajeong, Lee, Moon Hyoung, Lee, Kyu-Beck, Lee, Hyung-seok, Lee, JungEun, Lee, Hyun Hee, Lee, Po-Tsang, Leis, Liisi, Lemahieu, Wim, Leung, Janson, Li, Yan, Lie, Davina Ngoi Wah, Lifland, Howard, Lilienthal, Kadri, Lim, Wai, Limardo, Monica, Livrozet, Marine, Longhi, Selena, Lopes, Daniela, Lopes, Jose Antonio, Lorde, Nathan, Luxton, Grant, Ma, Mingyao, Madhrira, Machaiah, Madonia, Phillip, Maes, Bart, Mahadevan, Kumaradevan, Mahdi, Amar, Mahdi, Eamon, Maillard, Nicolas, Maixnerova, Dita, Majstorovic Barac, Karolina, Malecki, Robert, Malfait, Thomas, Malvica, Silvia, Mandayam, Sreedhar, Manley, Paul, Mansfield, Nick, Marcantoni, Carmelita, Mariat, Christophe, Marin, Tamara Malek, Marin, Lida Maria Rodas, Mark, Patrick, Marques, Joana, Martinez, Eduardo Gutierrez, Martinez, Stacy, Masset, Catherine, Masson, Ingrid, Mather, Amanda, Maung Myint, Thida Maung, Mayet, Valentin, McCafferty, Kieran, McCarthy, Ellen, McDonald, Stephen, McGreal, Kerri, McMahon, Kellyn, McNally, Andrew, McQuarrie, Emily, Medina, Allyson, Meeus, Gert, Mehta, Kshama, Mendoza, Elder, Menezes, Maria, Meng, Jerry, Messa, Piergiorgio, Messias, Ana, Miarka, Przemyslaw, Miglinas, Marius, Mikacic, Ivana, Mikhail, Ashraf, Milicevic, Martina, Minasian, Raffi, Moeller, Marcus, Mohey, Hesham, Mojarrab, Javad, Mok, Maggie Ming Yee, Moncasi, Eduardo Parra, Moonen, Martial, Morales, Wenceslao Adrian Aguilera, Moreno, Eduardo Verde, Moreno, Antolina, Morris, Adam, Moutzouris, Dimitrios, Moya, Mercedes Gonzalez, Mucha, Simon, Musolino, Michela, Napodano, Pietro, Natario, Ana, Negrea, Lavinia, Nelson, Bradley, Neuen, Brendon, Newsome, Britt, Ng, Kit Chung Jack, Nguyen, Thu, Nguyen, Viet, Nicolo, Clementine, Nitschke, Martin, Noble, Euan, Nolasco, Fernando, O'Lone, Emma, Ochoa, Adriana Sierra, Oh, Kook-Hwan, Oh, SeWon, Okoh, Pedro, Ombelet, Sara, O'Shaughnessy, Michelle, Ou, Shih-Hsiang, Packham, David, Padiyar, Aparna, Pai, Mei-Fen, Pamplona, Irene Agraz, Pan, Szu-Yu, Pandya, Bhavna, Papadia, Federica, Pardinhas, Clara, Parikh, Nishita, Parikh, Samir, Park, Hyeong Cheon, Park, Jung Tak, Parreira, Lucia, Passerini, Patrizia, Patak, Ramachandra, Patecki, Margret, Patel, Rajan, Patel, Jusmin, Patel Suthar, Meera, Patella, Gemma, Patrikyan, Artashes, Pavlovic, Drasko, Paxton, William, Peh, Chen, Peleg, Yonatan, Pelicano, Josep Miquel Blasco, Peng, Yu-Sen, Pereira de Vicente, Manuel, Perez, Jonay Pantoja, Perez, Erika, Perez de Jose, Ana, Pérez Gómez, María Vanessa, Perez Lluna, Leticia, Peri, Usha, Perico, Norberto, Philipponnet, Carole, Phua, Elaine, Piel, Julia, Pillai, Unnikrishnan, Pilmore, Helen, Plavljanic, Djuro, Plaza, Mercedes Velo, Pollock, Carol, Ponnusamy, Arvind, Ponti, Serena, Powell, Thomas, Pradhan, Nishigandha, Prado, Raul Fernandez, Prkacin, Ingrid, Pruthi, Rishi, Pugh, Dan, Quinn, Sarah, Quintana, Luis F, Raakesh, Lathika, Rabindranath, Kannaiyan, Radermacher, Luc, Radhakrishnan, Jai, Ragy, Omar Sherin Ibrahim, Raichoudhury, Ritesh, Raimundo, Mario, Randone, Paolo, Razavian, Mona, Reichel, Helmut, Reis, Marina, Remuzzi, Giuseppe, Reynolds, Annie, Ricchiuto, Anna, Rico, Ivon Maritza Bobadilla, Rigothier, Claire, Ritchie, Angus, Rivero, Maria Antonieta Azancot, Rizk, Dana, Ro, Han, Rodriguez, Alfred, Rodriguez Garcia, Eva, Roger, Simon, Rony, Mohammad, Rosenberg, Mai, Roueff, Stephane, Rovin, Brad, Roxburgh, Sarah, Ruiz, Mario, Rusinol, Helena Marco, Rychlik, Ivan, Sá, Helena, Salehi, Tania, Sánchez de la Nieta, Maria Dolores, Sanden, Silja, Santockiene, Lina, Santos, Patricia Valerio, Santos, Iara Da Silva, Sargsyan, Mari, Sarnow, Franziska, Sat, Sebahat, Satora, Ewa, Savuk, Ana, Sayer, Matthew, Schlieper, Georg, Schlosser, Mandy, Schmidt-Guertler, Hans, Schockaert, Olivier, Schulte, Kevin, Schulz, Lisa, Selvaskandan, Haresh, Semple, David, Sen, Shaundeep, Seppet, Elviira, Serrano, Antonio Galan, Serre, Jean-Emmanuel, Sevillano, Angel, Shah, Sapna, Shen, Yvonne, Sheridan, Brittany, Shu, Kai-Hsiang, Sightler, Ford, Silva, Sónia, Silva, Arnold, Sinha, Smeeta, Siriwardana, Amanda, Sitas, Zvonimir, Sivo, Carmen, Sizeland, Peter, Sly, Cathylee, Smith, Priscilla, Snow, Brian, Soares, Elsa Sofia Quadrado, Solazzo, Andrea, Solis, Elena Gutierrez, Solomon, Laurence, Song, Young Rim, Sousa, Helena, Spinowitz, Bruce, Stallworthy, Elizabeth, Stamellou, Eleni, Stanczyk, Malgorzata, Stangenberg, Stefanie, Stankovic, Marija, Stankuviene, Asta, Stea, Emma Diletta, Stompor, Tomasz, Storrar, Joshua, Sullivan, James, Sulowicz, Wladyslaw, Suyumova, Irina, Szeto, Cheuk Chun, Tamarit, Esther, Tan, Eddie, Tan, May, Tang, Sydney Chi Wai, Tang, Hon, Teixeira, Catarina, Telling, Kadri, Terrades, Natalia Ramos, Tesar, Vladimir, Tez, Didem, Thervet, Eric, Thibaudin, Damien, Thomas, Mark, Thyagarajan, Nikhil, Tkaczyk, Marcin, Torreggiani, Massimo, Trillini, Matias, Tsai, Shang-Feng, Tsai, Wan-Chuan, Tsai, Jer-Chia, Tseng, Po-Yu, Tumlin, James, Tung, Kuei-Ting, Turnbull, Angus, Udani, Suneel, Uhlinova, Jana, Unt, Kristin, Urciuolo, Federica, Vanacker, An, Vandewiele, Bert, Vaz, Alvaro, Veermae, Kristi, Viaene, Liesbeth, Vickiene, Alvita, Vigano, Sara, Vila, Maria Antonia Munar, Vilayur, Eswari, Villanueva, Caridad Martinez, Villarroya, Cristina Medrano, Villen, Alejandro Soria, Viramontes, Veronica, Vita, Caterina, Vujcic, Dunja, Wahba, Mona, Wan, Susan, Wang, Chih-Hsien, Warling, Xavier, Waters, Gerald, Waugh, Jane, Weiland, Lea, Weiner, Stefan, Weinreich, Thomas, Werth, Stephan Christian, Wickens, Olivia, Wijeratne, Vidu, Wilder, Karen, Willcocks, Lisa, Williams, Allister, Winiarska, Agata, Wirtz, Nikolaus, Wolf, Lothar, Wolf, Gunter, Wong, Muh Geot, Wong, Yick Hei, Wong, Sze Ho Sunny, Workeneh, Biruh, Wu, Ming-Ju, Wu, Hon-Yen, Wyndham, Roger, Yang, Jihyun, Yang, Ju-Yeh, Yeap, Chii, Yim, Ka Fai, Yong, Kenneth, Yoo, Tae-Hyun, Yoon, Songuk, Yu, Tung-Min, Yue, Tak Tai Andrew, Zakari, Michel, Zakauskiene, Urte, Zaoui, Philippe, Zbrzezniak, Justyna, Zielinska, Dorota, Zizzi, Carlotta Federica, Rovin, Brad H, Heerspink, Hiddo J L, Alpers, Charles E, Bieler, Stewart, Diva, Ulysses A, Inrig, Jula K, Kohan, Donald E, Komers, Radko, Małecki, Robert, Mercer, Alex, Noronha, Irene L, Oh, Se Won, Peh, Chen Au, Praga, Manuel, Preciado, Priscila, Rheault, Michelle N, Rote, William E, Tang, Sydney C W, Trachtman, Howard, Trimarchi, Hernán, Tumlin, James A, and Perkovic, Vlado
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- 2023
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6. Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial
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Alarmartine, Eric, Barratt, Jonathan, Chae, Dong Wan, Del Vecchio, Lucia, Floege, Jurgen, Hwang, Shang-Jyh, Jelakovic, Bojan, Maes, Bart, Malecki, Robert, Miglinas, Marius, Nolasco, Fernando Eduardo Barbosa, Praga, Manual, Rabindranath, Kannaiyan, Rosenberg, Mai, Rovin, Brad, Tang, Sydney Chi Wai, Tesar, Vladmir, Wong, Muh Geot, Bose, Bhadran, Gangadharan, Muralikrishna, McDonald, Stephen, Peh, Chen, Jahan, Sadia, Yeap, Chii, Clayton, Philip, Irish, Georgina, Thyagarajan, Nikhil, Hollett, Peter, Krishnasamy, Rathika, Carroll, Robert, Jesudason, Shilpanjali, Crail, Susan, Coates, Toby, Waugh, Jane, Noble, Euan, Mahadevan, Kumaradevan, Campbell, Victoria, Salehi, Tania, Lim, Wai, Boudville, Neil, Chakera, Aron, Chan, Doris, Krishnan, Anoushka, Eqbal, Yusuf, Gillies, Alastair, Vilayur, Eswari, Maung Myint, Thida Maung, Gray, Nicholas, Cheetham, Melissa, Pollock, Carol, Cooper, Bruce, Mather, Amanda, Roxburgh, Sarah, Shen, Yvonne, Stangenberg, Stefanie, Siriwardana, Amanda, O'Lone, Emma, Wan, Susan, Neuen, Brendon, Tsun Kit Ha, Jeffrey, Kim, Dana, Heath, Lauren, Jain, Arunima, Phua, Elaine, Li, Yan, Gallagher, Martin, Jardine, Meg, Ritchie, Angus, Razavian, Mona, Foote, Celine, Wyndham, Roger, Sen, Shaundeep, Endre, Zoltan, Erlich, Jonathan, Fernando, Mangalee, Yong, Kenneth, Luxton, Grant, Kotwal, Sradha, Roger, Simon, Wijeratne, Vidu, Packham, David, Fraser, Ian, Vandewiele, Bert, Laute, Margo, Lemahieu, Wim, Jamar, Sofie, Ombelet, Sara, Meeus, Gert, Decupere, Marc, Schockaert, Olivier, Doubel, Peter, Viaene, Liesbeth, Radermacher, Luc, Masset, Catherine, Moonen, Martial, Firre, Eric, Milicevic, Martina, Warling, Xavier, Vanacker, An, Malfait, Thomas, Durlen, Ivan, Horvatic, Ivica, Savuk, Ana, Gellineo, Lana, Karanovic, Sandra, Dika, Zivka, Plavljanic, Djuro, Mikacic, Ivana, Trajbar Kentric, Dubravka, Barisic, Dunja, Stankovic, Marija, Majstorovic Barac, Karolina, Kruljac, Ivan, Pavlovic, Drasko, Drinkovic, Martin, Prkacin, Ingrid, Barbic, Jerko, Sitas, Zvonimir, Vujcic, Dunja, Rychlik, Ivan, Benesova, Anna, Drinovska, Klara, Kratka, Karolina, Maixnerova, Dita, Ilmoja, Madis, Unt, Kristin, Lilienthal, Kadri, Auerbach, Asta, Leis, Liisi, Piel, Julia, Adoberg, Annika, Kolvald, Kulli, Veermae, Kristi, Telling, Kadri, Seppet, Elviira, Uhlinova, Jana, Zaoui, Philippe, Carron, Pierre-Louis, Masson, Ingrid, Dinic, Miriana, Thibaudin, Damien, Broyet, Christian, Maillard, Nicolas, Mohey, Hesham, Mariat, Christophe, Claisse, Guillaume, Alamartine, Eric, Dussol, Bertrand, Burtey, Stephane, Chiche-Jourde, Noemie, Serre, Jean-Emmanuel, Jeantet, Guillaume, Chenine, Leila, Blanchard, Anne, Roueff, Stephane, Thervet, Eric, Fouassier, David, Buffet, Alexandre, Livrozet, Marine, Gaisset, Roxane, Karras, Alexandre, Heng, Anne-Elisabeth, Garrouste, Cyril, Philipponnet, Carole, Nicolo, Clementine, Atenza, Alba, Lanaret, Camille, Greze, Clarisse, Mayet, Valentin, Dumond, Clement, Delmas, Yahsou, Combe, Christian, Rigothier, Claire, Burguet, Laure, Labat, Aurore, Mucha, Simon, de Précigout, Valérie, Weinreich, Thomas, Reichel, Helmut, Draganova, Diliana, Wolf, Lothar, Hohenstein, Bernd, Heinrichs, Sven, Kulka, Simone, Sat, Sebahat, Weiland, Lea, Krueger, Thilo, Wolf, Gunter, Kettner, Christiane, Schlosser, Mandy, Herfurth, Johann Konstantin, Koch, Annegret, Busch, Martin, Werth, Stephan Christian, Nitschke, Martin, Cakiroglu, Figen, Sarnow, Franziska, Schulz, Lisa, Weiner, Stefan, Wirtz, Nikolaus, Koester, Eric, Moeller, Marcus, Stamellou, Eleni, Sanden, Silja, Schmidt-Guertler, Hans, Bernhardt, Wanja, Patecki, Margret, Schlieper, Georg, Schulte, Kevin, Girardet, Annette, Kunzendorf, Ulrich, Kwan, Lorraine Pui Yuen, Mok, Maggie Ming Yee, Chan, Gary Chi Wang, Ma, Mingyao, Lie, Davina Ngoi Wah, Chan, Anthony Ting Pong, Szeto, Cheuk Chun, Ng, Kit Chung Jack, Cheung, Siu Fai, Yue, Tak Tai Andrew, Fung, Ka Shun Samuel, Tang, Hon, Yim, Ka Fai, Law, Wai Ping, Wong, Yick Hei, Lam, Chi Kwan Darwin, Wong, Sze Ho Sunny, Marcantoni, Carmelita, Aliotta, Roberta, Deodato, Francesca, Patella, Gemma, Comi, Nicolino, Vita, Caterina, Carullo, Nazareno, Bolignano, Davide, Musolino, Michela, Trillini, Matias, Perico, Norberto, Remuzzi, Giuseppe, Daina, Erica, Biancone, Luigi, Colla, Loredana, Burdese, Manuel, Cogno, Chiara, Boaglio, Elena, Abbasciano, Isabella, Zizzi, Carlotta Federica, Randone, Paolo, Napodano, Pietro, Ricchiuto, Anna, Cassia, Matthias, Accarino, Simone, Cozzolino, Mario, Baccaro, Rocco, Costanzi, Stefano, Di Maio, Federica, Arena, Maria, Urciuolo, Federica, Vigano, Sara, Cavalli, Andrea, Limardo, Monica, Bordoli, Monica, Ponti, Serena, Longhi, Selena, Solazzo, Andrea, Giaroni, Francesco, Donati, Gabriele, Torreggiani, Massimo, Catucci, Davide, Colucci, Marco, Esposito, Vittoria, Esposito, Ciro, Gesualdo, Loreto, Capaccio, Flavia, Diletta Stea, Emma, Sivo, Carmen, Annese, Francesca, Papadia, Federica, Messa, Piergiorgio, Belingheri, Mirco, Passerini, Patrizia, Malvica, Silvia, Vickiene, Alvita, Zakauskiene, Urte, Asakiene, Egle, Bumblyte', Inga Arune, Stankuviene, Asta, Santockiene, Lina, Hayat, Ashik, Williams, Allister, Sizeland, Peter, Tan, Eddie, Waters, Gerald, Chan, Lai Wan, Henderson, Andrew, Turnbull, Angus, McNally, Andrew, Reynolds, Annie, Pilmore, Helen, Dittmer, Ian, Manley, Paul, Stallworthy, Elizabeth, Goh, Tze, Semple, David, Collins, Michael, Curry, Elizabeth, Ahmed, Jafar, Nguyen, Thu, Winiarska, Agata, Zbrzezniak, Justyna, Stompor, Tomasz, Krajewska, Magdalena, Augustyniak-Bartosik, Hanna, Zielinska, Dorota, Jander, Anna, Stanczyk, Malgorzata, Tkaczyk, Marcin, Miarka, Przemyslaw, Aksamit, Dariusz, Jaskowski, Piotr, Sulowicz, Wladyslaw, Cieniawski, Dominik, Gontarek-Kacprzak, Julita, Felicjanczuk, Elzbieta, Kwella, Norbert, Kwella, Bogna, Satora, Ewa, Fernandes, João Carlos, Gomes, Ana Marta, Reis, Marina, Lopes, Daniela, Almeida, Catarina, Sá, Helena, Figueiredo, Ana Carolina, Pardinhas, Clara, Almeida, Edgar, Raimundo, Mario, Cortesão Costa, Ana, Falcao Goncalves, Luis Pedro, Fernandes, Sara, Silva, Sónia, Teixeira, Catarina, Fernandes, Adriana, Nolasco, Fernando, Alves, Patricia, Gois, Mario, Fonseca, Nuno, Messias, Ana, Menezes, Maria, Cardoso, Filipa, Sousa, Helena, Marques, Joana, Barata, Rui, Lopes, Jose Antonio, Jorge, Sofia, Gameiro, Joana, de Almeida Agapito Fonseca, Jose Nuno, Goncalves, Sara, Farinha, Ana, Valerio Santos, Patricia, Natario, Ana, de Jesus Barreto, Jose Carlos, Abrantes, Catarina, Quadrado Soares, Elsa Sofia, Soares Felgueiras, Joana de Sousa, Cunha, Liliana, Parreira, Lucia, Furtado, Teresa, Vaz, Alvaro, Oh, Kook-Hwan, Lee, Hajeong, Joong Kim, Se, Jeong, Jong Cheol, Hoon Kim, Yeong, Kim, Yunmi, Park, Hyeong Cheon, Choi, Hoon Young, Wook Kim, Hyung, Lee, Moon Hyoung, Yoon, Songuk, Lee, Kyu-Beck, Hyun, YoungYoul, Yoo, Tae-Hyun, Han, Seung Hyeok, Park, Jung Tak, Kim, Sunggyun, Song, Young Rim, Kim, Jwa-Kyung, Lee, Hyung-seok, Joo, Narae, Lee, JungEun, Ryoun Jang, Hye, Jeon, Junseok, Chung, Wookyung, Lee, HyunHee, Chang, Jae Hyun, Chun, Ka Yeong, Jung, Ji Yong, Ro, Han, Kim, Aejin, Jo, Sang-Kyung, Yang, Jihyun, Kim, Myung-Gyu, Oh, SeWon, Martinez Villanueva, Caridad, Gimeno, Ana Vilar, Andres Useche Bonilla, Gustavo, Tamarit, Esther, Galan Serrano, Antonio, Verde Moreno, Eduardo, Fernandez, Jose Luño, Goicoechea Diezhandino, Maria Angeles, Verdalles Guzman, Ursula, de Jose, Ana Perez, Ortiz Arduan, Alberto, Pérez Gómez, María Vanessa, Martín Cleary, Catalina, Prado, Raul Fernandez, Goma, Elena, Ballarin, Jose, Encarnacion, Montserrat Diaz, Da Silva Santos, Iara, Marco Rusinol, Helena, Furlano, Monica, Arias, Carlos, Barrios, Clara, Garcia, Eva Rodriguez, Sierra Ochoa, Adriana, Vizcaino Castillo, Belen, Pantoja Perez, Jonay, Gonzalez Moya, Mercedes, Sargsyan, Mari, Calatayud Aristoy, Emma, Bernabeu, Ana Avila, Perez Lluna, Leticia, Malek Marin, Tamara, Antonia Munar Vila, Maria, Bobadilla Rico, Ivon Maritza, Allende Burgos, Natalia, Gutierrez Martinez, Eduardo, Gutierrez Solis, Elena, Sevillano, Angel, Merida 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7. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
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Seyed Rasoul, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Zapata, Maria Elisa, Zaw, Ko Ko, Zejglicova, Kristyna, Zeljkovic Vrkic, Tajana, Zeng, Yi, Zhang, Luxia, Zhang, Zhen-Yu, Zhao, Dong, Zhao, Ming-Hui, Zhen, Shiqi, Zheng, Yingfeng, Zholdin, Bekbolat, Zhu, Dan, Zins, Marie, Zitt, Emanuel, Zocalo, Yanina, Zoghlami, Nada, Zuñiga Cisneros, Julio, and Ezzati, Majid
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- 2021
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8. SGLT2 Inhibitors and Their Effect on Urolithiasis: Current Evidence and Future Directions.
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Dika, Živka, Živko, Marijana, Kljajić, Marina, and Jelaković, Bojan
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URINARY calculi , *TYPE 2 diabetes , *KIDNEY stones , *GLYCEMIC control , *CALCIUM oxalate - Abstract
Urolithiasis (UL) is increasingly prevalent due to rising cardiorenometabolic diseases, posing significant management challenges despite advances in urological techniques. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, primarily used for type 2 diabetes mellitus, chronic kidney disease, and heart failure, have emerged as a potential novel approach for UL treatment. These inhibitors may help reduce the risk of urolithiasis, particularly in patients with diabetes, by improving glycemic control and altering urinary chemistry, which are crucial factors in stone formation. However, the changes in urinary composition induced by SGLT2 inhibitors might also increase the risk of uric acid stone formation. This review evaluates the potential of SGLT2 inhibitors in managing UL, highlighting both the benefits and the risks. While these inhibitors show promise in reducing new and recurrent urinary stones in patients with diabetes, data on their effects in patients without diabetes who form stones are limited. Current human evidence largely comes from post hoc analyses of randomized controlled trials (RCTs) and large-scale database studies, with only one study providing detailed stone composition data. Experimental studies in animal models and cell lines have focused on calcium oxalate (CaOx) stones, showing that SGLT2 inhibitors specifically target CaOx stone formation and related renal inflammation. Although primarily studied for CaOx stones, their potential impact on other calcium-containing stones, such as calcium phosphate, remains promising. Further research is needed to explore their therapeutic potential and optimize treatment strategies. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants
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10. The Role of Antibiotic Therapy on the Children's Neurological Outcome in Preterm Premature Rupture of Membranes
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Bulat, Stjepan, Dika, Živka, Lovrić, Boris, Matak, Luka, Elveđi Gašparović, Vesna, Juras, Josip, Bulat, Stjepan, Dika, Živka, Lovrić, Boris, Matak, Luka, Elveđi Gašparović, Vesna, and Juras, Josip
- Abstract
Preterm premature rupture of membranes (PPROM) occurs in 3% of all pregnancies and is responsible for approximately one-third of all preterm births, causing significant perinatal morbidity and fetal death. In a significant number of PPROM cases an infection is present although it is sometimes difficult to determine clinically. Our knowledge of pathophysiology of intrauterine infection/inflammation and impact of antibiotic therapy on its clinical course is elementary. It is known that intrauterine infection/inflammation is a significant risk factor for developing neurological impairment in children. Prophylactic administration of antibiotics might eradicate infection in women with PPROM and improve neonatal outcomes, on the other hand, it could only increase the period of latency and suppress infection to a subclinical level without eradicating the underlying infection, leaving the fetus in an unfavorable intrauterine environment. Still, the European and the American guidelines recommend routine administration of antibiotic therapy in women presenting with PPROM. Studies have shown that administration of antibiotics increases the period of latency and improves certain short-term neurological outcomes such as reducing the rate of abnormal cerebral ultrasound scan prior to the discharge from hospital, but it does not reduce perinatal mortality, the rate of preterm births and does not have an effect on long-term neurological outcomes. Furthermore, guidelines for antibiotics administration on PPROM are largely based on deficient, low quality and possibly outdated evidence. Optimal regimen and duration of antibiotic therapy are not clear and new studies estimating changes in bacterial resistance and more common clinical use of cephalosporines in the clinical management of PPROM are necessary.
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- 2024
11. Early Cardiovascular Dysfunction in Prehypertension
- Author
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Jelaković, Ana, Dika, Živka, Herceg-Čavrak, Vesna, Laganović, Mario, Lović, Dragan, Jelaković, Bojan, Mancia, Giuseppe, Series Editor, Rosei, Enrico Agabiti, Series Editor, Zimlichman, Reuven, editor, and Julius, Stevo, editor
- Published
- 2019
- Full Text
- View/download PDF
12. Balkan Endemic Nephropathy and the Causative Role of Aristolochic Acid
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Jelaković, Bojan, Dika, Živka, Arlt, Volker M., Stiborova, Marie, Pavlović, Nikola M., Nikolić, Jovan, Colet, Jean-Marie, Vanherweghem, Jean-Louis, and Nortier, Joëlle L.
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- 2019
- Full Text
- View/download PDF
13. Consensus statement on screening, diagnosis, classification and treatment of endemic (Balkan) nephropathy
- Author
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Jelaković, Bojan, Nikolić, Jovan, Radovanović, Zoran, Nortier, Joelle, Cosyns, Jean-Pierre, Grollman, Arthur P, Bašić-Jukić, Nikolina, Belicza, Mladen, Bukvić, Danica, Čavaljuga, Semra, Čvorišćec, Dubravka, Cvitković, Ante, Dika, Živka, Dimitrov, Plamen, Đukanović, Ljubica, Edwards, Karen, Ferluga, Dušan, Fuštar-Preradović, Ljubica, Gluhovschi, Gheorghe, Imamović, Goran, Jakovina, Tratinčica, Kes, Petar, Leko, Ninoslav, Medverec, Zvonimir, Mesić, Enisa, Miletić-Medved, Marica, Miller, Frederick, Pavlović, Nikola, Pasini, Josip, Pleština, Stjepko, Polenaković, Momir, Stefanović, Vladislav, Tomić, Karla, Trnačević, Senaid, Lela, Ivana Vuković, and Štern-Padovan, Ranka
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Balkan Nephropathy ,Consensus ,Disease Management ,Humans ,Mass Screening ,aristolochic acid nephropathy ,consensus statement ,diagnostic criteria ,endemic nephropathy ,upper urothelial cancer ,Urology & Nephrology ,Clinical sciences - Abstract
Currently used diagnostic criteria in different endemic (Balkan) nephropathy (EN) centers involve different combinations of parameters, various cut-off values and many of them are not in agreement with proposed international guidelines. Leaders of EN centers began to address these problems at scientific meetings, and this paper is the outgrowth of those discussions. The main aim is to provide recommendations for clinical work on current knowledge and expertise. This document is developed for use by general physicians, nephrologists, urologist, public health experts and epidemiologist, and it is hoped that it will be adopted by responsible institutions in countries harboring EN. National medical providers should cover costs of screening and diagnostic procedures and treatment of EN patients with or without upper urothelial cancers.
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- 2014
14. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults
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Ruiz-Betancourt, Blanca Sandra, Russo, Paola, Rutkowski, Marcin, Sabanayagam, Charumathi, Sachdev, Harshpal S, Saidi, Olfa, Salanave, Benoit, Martinez, Eduardo Salazar, Salmerón, Diego, Salomaa, Veikko, Salonen, Jukka T, Salvetti, Massimo, Sánchez-Abanto, Jose, Sandjaja, Sans, Susana, Marina, Loreto Santa, Santos, Diana A, Santos, Ina S, Santos, Osvaldo, dos Santos, Renata Nunes, Santos, Rute, Saramies, Jouko L, Sardinha, Luis B, Sarrafzadegan, Nizal, Saum, Kai-Uwe, Savva, Savvas, Savy, Mathilde, Scazufca, Marcia, Rosario, Angelika Schaffrath, Schargrodsky, Herman, Schienkiewitz, Anja, Schipf, Sabine, Schmidt, Carsten O, Schmidt, Ida Maria, Schultsz, Constance, Schutte, Aletta E, Sein, Aye Aye, Sen, Abhijit, Senbanjo, Idowu O, Sepanlou, Sadaf G, Serra-Majem, Luis, Shalnova, Svetlana A, Sharma, Sanjib K, Shaw, Jonathan E, Shibuya, Kenji, Shin, Dong Wook, Shin, Youchan, Shiri, Rahman, Siani, Alfonso, Siantar, Rosalynn, Sibai, Abla M, Silva, Antonio M, Silva, Diego Augusto Santos, Simon, Mary, Simons, Judith, Simons, Leon A, Sjöberg, Agneta, Sjöström, Michael, Skovbjerg, Sine, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemyslaw, Smeeth, Liam, Smith, Margaret C, Snijder, Marieke B, So, Hung-Kwan, Sobngwi, Eugène, Söderberg, Stefan, Soekatri, Moesijanti YE, Solfrizzi, Vincenzo, Sonestedt, Emily, Song, Yi, Sørensen, Thorkild IA, Soric, Maroje, Jérome, Charles Sossa, Soumare, Aicha, Spinelli, Angela, Spiroski, Igor, Staessen, Jan A, Stamm, Hanspeter, Starc, Gregor, Stathopoulou, Maria G, Staub, Kaspar, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D, Stergiou, George S, Stessman, Jochanan, Stieber, Jutta, Stöckl, Doris, Stocks, Tanja, Stokwiszewski, Jakub, Stratton, Gareth, Stronks, Karien, Strufaldi, Maria Wany, Suárez-Medina, Ramón, Sun, Chien-An, Sundström, Johan, Sung, Yn-Tz, Sunyer, Jordi, Suriyawongpaisal, Paibul, Swinburn, Boyd A, Sy, Rody G, Szponar, Lucjan, Tai, E Shyong, Tammesoo, Mari-Liis, Tamosiunas, Abdonas, Tan, Eng Joo, Tang, Xun, Tanser, Frank, Tao, Yong, Tarawneh, Mohammed Rasoul, Tarp, Jakob, Tarqui-Mamani, Carolina B, Tautu, Oana-Florentina, Braunerová, Radka Taxová, Taylor, Anne, Tchibindat, Félicité, Theobald, Holger, Theodoridis, Xenophon, Thijs, Lutgarde, Thuesen, Betina H, Tjonneland, Anne, Tolonen, Hanna K, Tolstrup, Janne S, Topbas, Murat, Topór-Madry, Roman, Tormo, María José, Tornaritis, Michael J, Torrent, Maties, Toselli, Stefania, Traissac, Pierre, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Trinh, Oanh TH, Trivedi, Atul, Tshepo, Lechaba, Tsigga, Maria, Tsugane, Shoichiro, Tulloch-Reid, Marshall K, Tullu, Fikru, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Turley, Maria L, Tynelius, Per, Tzotzas, Themistoklis, Tzourio, Christophe, Ueda, Peter, Ugel, Eunice E, Ukoli, Flora AM, Ulmer, Hanno, Unal, Belgin, Uusitalo, Hannu MT, Valdivia, Gonzalo, Vale, Susana, Valvi, Damaskini, van der Schouw, Yvonne T, Van Herck, Koen, Van Minh, Hoang, van Rossem, Lenie, Van Schoor, Natasja M, van Valkengoed, Irene GM, Vanderschueren, Dirk, Vanuzzo, Diego, Vatten, Lars, Vega, Tomas, Veidebaum, Toomas, Velasquez-Melendez, Gustavo, Velika, Biruta, Veronesi, Giovanni, Verschuren, WM Monique, Victora, Cesar G, Viegi, Giovanni, Viet, Lucie, Viikari-Juntura, Eira, Vineis, Paolo, Vioque, Jesus, Virtanen, Jyrki K, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vlasoff, Tiina, Vollenweider, Peter, Völzke, Henry, Voutilainen, Sari, Vrijheid, Martine, Wade, Alisha N, Wagner, Aline, Waldhör, Thomas, Walton, Janette, Bebakar, Wan Mohamad Wan, Mohamud, Wan Nazaimoon Wan, Wanderley, Rildo S, Jr., Wang, Ming-Dong, Wang, Qian, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nicholas, Weber, Adelheid, Wedderkopp, Niels, Weerasekera, Deepa, Whincup, Peter H, Widhalm, Kurt, Widyahening, Indah S, Wiecek, Andrzej, Wijga, Alet H, Wilks, Rainford J, Willeit, Johann, Willeit, Peter, Wilsgaard, Tom, Wojtyniak, Bogdan, Wong-McClure, Roy A, Wong, Justin YY, Wong, Jyh Eiin, Wong, Tien Yin, Woo, Jean, Woodward, Mark, Wu, Frederick C, Wu, Jianfeng, Wu, Shouling, Xu, Haiquan, Xu, Liang, Yamborisut, Uruwan, Yan, Weili, Yang, Xiaoguang, Yardim, Nazan, Ye, Xingwang, Yiallouros, Panayiotis K, Yngve, Agneta, Yoshihara, Akihiro, You, Qi Sheng, Younger-Coleman, Novie O, Yusoff, Faudzi, Yusoff, Muhammad Fadhli M, Zaccagni, Luciana, Zafiropulos, Vassilis, Zainuddin, Ahmad A, Zambon, Sabina, Zampelas, Antonis, Zamrazilová, Hana, Zdrojewski, Tomasz, Zeng, Yi, Zhao, Dong, Zhao, Wenhua, Zheng, Wei, Zheng, Yingfeng, Zholdin, Bekbolat, Zhou, Maigeng, Zhu, Dan, Zhussupov, Baurzhan, Zimmermann, Esther, Cisneros, Julio Zuñiga, Bentham, James, Di Cesare, Mariachiara, Bilano, Ver, Bixby, Honor, Zhou, Bin, Stevens, Gretchen A, Riley, Leanne M, Taddei, Cristina, Hajifathalian, Kaveh, Lu, Yuan, Savin, Stefan, Cowan, Melanie J, Paciorek, Christopher J, Kengne, Andre Pascal, Zhu, Aubrianna, and Ezzati, Majid
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- 2017
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15. Evaluacija dijagnostičkih kriterija za endemsku nefropatiju
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Dika, Živka, Jelaković, Bojan, and dostupno, nije
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medicine ,endemska nefropatija ,nefropatija aristolohične kiseline ,dijagnostički kriteriji ,TGFβ - Abstract
EN je kronična nefropatija aristolohične kiseline čija se učestalost nije bitnije mijenjala posljednjih tri desetljeća. U EN selima bilježi se pomak u postavljanju dijagnoze EN prema starijoj dobi. Ostali i rizični u EN selima vjerojatno neće razviti nefropatiju budući da su prije tri desetljeća u dobi u kojoj se sada nalaze spomenute SZO podskupine (45-50 godina) bili oboljeli od EN, a rizični i ostali sada nemaju znakove bubrežne bolesti što otvara pitanje ranije izloženosti spomenutih podskupina etiološkom čimbeniku kao i pitanje mogućeg nestanka EN. Anemija koja je inače obilježje kronične bubrežne bolesti nije se pokazala dobrim biljegom u razlikovanju pojednih SZO podskupina pa više ne treba biti uključena u dijagostičke kriterije. Osim toga, nije bilo razlike između kontrolnih i EN sela kao niti između pojednih SZO podskupina test trakom za eritocituriju, pa time taj test nije dobar test probira za tumor prijelaznog epitela mokraćnog sustava. Iako ranu fazu EN karakterizira oštećenje proksimalnog tubula određivanje LAP se nije pokazalo korisno u razlikovanju pojednih SZO podskupina kao niti EN sela od kontrolnih sela. Osim toga, progresijom nefropatije naročito u uznapredovaloj fazi prisutna je intersticijska fibroza a TGFbeta je ključni čimbenik u procesu bubrežne fibroze (99). Prema nekim istraživanjima koncentracija TGF beta u mokraći ne pokazuje povezanost sa stupnjem bubrežne fibroze (153; 171). U našem istraživanju TGF beta u mokraći nije se pokazao korisnim kako u razlikovanju pojednih SZO podskupina tako i u dijagnosticiranju EN. Procjena bubrežne funkcije prema MDRD jednadžbi kao i uzdužni promjeri i debljina parenhima bubrega su se pokazali kao značajni pokazatelji u razlikovanju pojednih SZO podskupina u ovom istraživanju te bi ih trebalo uključiti u dijagnostičke kriterije za EN. Također jedan od značajnih biljega u probiru i dijagnosticiranju EN u istraživanju bio je i alfa 1mCR. Na temelju naših rezulatata granična vrijednost za probir populacije u EN selima bi trebala biti 23,5 mg/g kreatinina, a ne dosadašnjih 15 mg/g, dok za postavljanje dijagnoze EN 31,5 mg/g kreatinina. Pozitivna obiteljska anamneza za EN za 5,8 puta povećava vjerojatnost oboljenja od EN u odnosu na one bez pozitivne anamneze pa je bitan kriterij u probiru populacije u EN selima ali i u dijagnosticiranju EN. Ukupno gledajući, osobe s pozitivnom obiteljskom anamnezom za EN što odgovara podskupini rizičnih prema SZO kriterijima kao i onih s alfa 1mCR iznad 23,5 mg/g kreatinina koji u ovom istraživanju obuhvaćaju dio podskupine sumnjivih prema SZO kriterijima čine posebno ugrožene skupine za razvoj EN te zahtjevaju redovito medicinsko praćenje., EN is a chronic aristolochic acid nephropathy whose prevalence has not been changed significantly in the last 3 decades. In EN villages there has been a shift towards an older age in diagnosing EN. We do not expect the development of EN in persons in the WHO subgroups of others and those at risk because at their age (45-50 yrs) 30 years ago there were persons in WHO subgroup of the diseased, but in this study the persons in the subgroups of others and those at risk do not have the signs of kidney disease. The aforementioned data rise the question of the exposure to etiological agent 30 years ago as well as the question of plausible disappearance of EN. Anemia, a characteristic of a chronic kidney disease, has not shown to be a good marker in differentiating WHO subgruops and therefore should not be used as a diagnostic criterion for EN. Furthermore, there was no difference in blood in urinary dipstick test between EN and control villages as well as among the study subgroups, Therefore, this test is not a good screening tool in detecting those with urothelial tumor among farmers in EN villages. Although the early phase of EN is characterized by the proximal tubule damage, the proximal tubule enzyme LAP has not shown to be a good marker in differentiating the study subgroups. Moreover, the progression of EN, especially in the advance stage of the disease is characterized by interstital renal fibrosis and TGF beta in renal fibrosis plays a central role (99). Several studies have shown no correlation between urinary TGF beta and histological findings of renal fibrosis (153, 171). In our study urinary TGF beta has not shown to be a good marker in differentiating the study subgroups. In our study the assesment of kidney function by MDRD formula as well as both kidney lenght and parenchima thickness, have shown to be good markers in differentiating the study subgroups and therefore should be implemented into the diagnostic criteria for EN. Also, alpha 1mCR has shown to be a great marker in screening and diagnosing EN in the study, Based on our results the cut off value of alpha 1mCR for screening should be 23,5 mg/g creatinine instead of 15 mg/g creatinine in the present criteria, while for making a diagnosis of EN 31,5 mg/g creatinine. Positive family history for EN increases 5,8 times the risk for developing EN compared to a negative one. Therefore, positive family history for EN is an important criterion for screening and diagnosing EN. Taken together, persons with positive family history for EN, i.e. WHO subgrup of those at risk as well as those with alpha 1mCR greater than 23,5 mg/g creatinine who in our study partly represent persons in the WHO subgroup of suspected of having EN, are persons with greater risk for developing EN and therefore should be regularly followed up by their GPs.
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- 2023
16. Early Cardiovascular Dysfunction in Prehypertension
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Jelaković, Ana, primary, Dika, Živka, additional, Herceg-Čavrak, Vesna, additional, Laganović, Mario, additional, Lović, Dragan, additional, and Jelaković, Bojan, additional
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- 2018
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17. Uromodulin – a Link between Sodium Excretion and Alteration in Circadian Blood Pressure Pattern in Prehypertensives
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Josipović, Josipa, Šimičević, Livija, Dika, Živka, Bulj, Nikola, Vrsalović, Mislav, Jelaković, Bojan, Josipović, Josipa, Šimičević, Livija, Dika, Živka, Bulj, Nikola, Vrsalović, Mislav, and Jelaković, Bojan
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Although changes in dietary sodium intake alter blood pressure (BP) in salt-sensitive individuals, pathophysiological mechanisms are still unknown. It has been reported that uromodulin is involved in sodium tubular transport, and genome-wide association studies pointed to UMOD gene as one of the most important gene candidates for arterial hypertension. Our aim was to analyze urinary uromodulin, salt intake and BP in 326 young middle-aged subjects (mean age 36±8 years, 49.4% male). In a subgroup of 175 individuals, ambulatory blood pressure monitoring and echocardiogram were performed. Uromodulin was determined by ELISA. According to the JNC-7 criteria, subjects were classified as optimal BP (n=103, men 72%), prehypertension (PHT) (n=143, men 43%) and hypertension (HT) (n= 80, men 38%). There were no differences in age, salt intake, estimated glomerular filtration rate, sodium excretion and uromodulin among BP groups. However, in PHT subjects, uromodulin was positively associated with fractional sodium excretion and negatively with 24-h sodium excretion and diastolic BP dip. These findings point to the effect of uromodulin on sodium reabsorption along the nephron and consequently circadian BP alteration in prehypertensives., Promjene u dnevnom unosu kuhinjske soli u osoba osjetljivih na sol utječu na arterijski tlak (AT), ali točan patofiziološki mehanizam još nije u potpunosti razjašnjen. Cilj ove studije je bio istražiti izlučivanje uromodulina (UM) i natrija mokraćom i povezanost s AT u mlađih odraslih osoba. U 326 ispitanika (medijan dobi 36, IQR 18-48, 64,6% muškarci) analizirani su uzorci krvi i mokraće uzeti natašte i izmjeren je AT u ordinaciji, a kod 175 ispitanika učinjeno je kontinuirano mjerenje arterijskoga tlaka. UM je određen metodom ELISA. Prema klasifikaciji JNC-7 optimalni AT, predhipertenzija (PHT) i hipertenzija (HT) su dijagnosticirani u 103 (72% m), 143 (43% m) i 80 (38% m) ispitanika. Nije bilo razlike u dobi, unosu kuhinjske soli, procijenjenoj stopi glomerularne filtracije niti u izlučivanju natrija i UM mokraćom između kategorija AT. Uočena je pozitivna povezanost UM s frakcijskom ekskrecijom natrija, a negativna s 24-satnom natriurijom i noćnim sniženjem dijastoličkoga AT u PHT. Ovi rezultati upućuju na povezanost UM s tubularnom reapsorpcijom natrija i promjenama dnevnoga ritma AT u predhipertoničara.
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- 2023
18. Preporuke za dijagnosticiranje, prevenciju i liječenje citomegalovirusa u bolesnika s presađenim solidnim organom
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Bašić-Jukić, Nikolina, Miličić, Davor, Samaržija, Miroslav, Jelaković, Bojan, Kaštelan, Željko, Bošnjak, Zrinka, Mareković, Ivana, Židovec Lepej, Snježana, Grgić, Ivana, Barbić, Jerko, Rački, Sanjin, Skorić, Boško, Čikeš, Maja, Džubur, Feđa, Merćep, Iveta, Prkačin, Ingrid, Maksimović, Bojana, Filipec Kanižaj, Tajana, Mrzljak, Anna, Furić-Čunko, Vesna, Katalinić, Lea, Fištrek-Prlić, Margareta, Sabljić, Zoran, Dika, Živka, Pavliša, Gordana, Radunović, Danilo, Prelević, Vladimir, Atić, Armin, Jurić, Ivana, Bašić-Jukić, Nikolina, Miličić, Davor, Samaržija, Miroslav, Jelaković, Bojan, Kaštelan, Željko, Bošnjak, Zrinka, Mareković, Ivana, Židovec Lepej, Snježana, Grgić, Ivana, Barbić, Jerko, Rački, Sanjin, Skorić, Boško, Čikeš, Maja, Džubur, Feđa, Merćep, Iveta, Prkačin, Ingrid, Maksimović, Bojana, Filipec Kanižaj, Tajana, Mrzljak, Anna, Furić-Čunko, Vesna, Katalinić, Lea, Fištrek-Prlić, Margareta, Sabljić, Zoran, Dika, Živka, Pavliša, Gordana, Radunović, Danilo, Prelević, Vladimir, Atić, Armin, and Jurić, Ivana
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Infekcija citomegalovirusom (CMV) još uvijek predstavlja jednu od najčešćih komplikacija u primatelja solidnih organa. Povezana je s povećanim rizikom različitih komplikacija, uključujući gubitak presatka i smrt primatelja. Multidisciplinarni panel stručnjaka koji se bave transplantacijom solidnih organa okupio se radi donošenja preporuka za dijagnostiku, prevenciju i liječenje CMV infekcije. Preporuke su prvenstveno posvećene suvremenom pristupu dijagnozi CMV infekcije, mogućnostima liječenja novim antivirusnim lijekovima i načinima liječenja rezistentne/refraktorne CMV bolesti., Cytomegalovirus (CMV) infection remains one of the most common complications in solid organ transplant recipients. It is associated with an increased risk of different complications, including graft loss and mortality. A multidisciplinary panel of solid organ transplant experts gathered to revise and adopt consensus recommendations on CMV diagnostics, prevention, and treatment. Recommendations focus on the current approach to diagnosing CMV infection, different methods of prevention, possibilities of treatment with novel antiviral therapies, and approaches to treating resistant/refractory disease.
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- 2023
19. Prevalence of incidental chronic kidney disease and patient characteristics - results of the EH-UH 2 study and the ENAH project
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Domislović, Marija, Gellineo, Lana, Jelaković, Ana, Dika, Živka, Domislović, Viktor, Đapić, Krešimir, Karanović, Sandra, Vuković Brinar, Ivana, Bukal, Nikolina, Abramović Barić, Mirta, Brzić, Ivan, and Jelaković, Bojan
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Chronic Kidney Disease, CKD EPI equation, albuminuria, estimated glomerular filtra- tion rate, EH-UH 2 ,Chronic Kidney Disease ,CKD EPI equation ,albuminuria ,estimated glomerular filtration rate ,EH-UH 2 ,General Medicine - Abstract
Introduction: Chronic kidney disease (CKD) is an independent risk factor for cardiovascular (CV) disease and premature deaths. The worldwide prevalence of CKD in 2017 in the general population is 9.1%. In this paper our primary aim was to present preliminary data on incidental, i.e., newly discov- ered CKD and the overall prevalence of CKD in the adult population in Croatia. Secondary aim was to compare these data with the data of the CKD prevalence of the adult population from the rural part of Croatia (results of the ENAH study). Materials and Methods: This cross-sectional observational study included random, representative sample of general adults in Croatia, 781 subjects who were part of the large cohort from the EH-UH 2 study. The eGFR was calculated by creatinine-based CKD EPI equation. Albuminuria was determined from the albumin to creatinine ratio in urine (ACR) in 691 subjects. Results: The overall prevalence of CKD in Croatia was 12.7%, of which 9.5% were newly discovered CKD, and only 3.2% were subjects with previously known CKD. According to the albuminuria level, 30.7% of the adult population belonged to the group with a moderate risk of CKD progression, and 7% had a high risk, while 2.5% of the study subjects had a very high risk. Predictors for newly discov- ered CKD are older age, higher urate and potassium, antihypertensive therapy, angina pectoris, atrial fibrillation, lower hemoglobin level. Conclusions: These results continue in a pilot project of the Croatian Kidney Society and the Croatian Hypertension League on the implementation of an action plan to detect new kidney disease in the general population in real life, in a collaboration of primary care physicians and nephrologists.
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- 2022
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20. Endemic (Balkan) Nephropathy: A Disease Caused by Aristolochic Acid
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Jelaković, Bojan, Dika, Živka, Grollman, Arthur P., and Vitale, Ksenija, editor
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- 2012
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21. Diminishing benefits of urban living for children and adolescents’ growth and development
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Mishra, Anu, Zhou , Bin, Rodriguez-Martinez, Andrea, Sorić, Maroje, Dika, Živka, Jelaković, Bojan, Jureša, Vesna, Majer, Marjeta, Mišigoj-Duraković, Marjeta, Križan, Helena, Musić Milanović, Sanja, Stevanović, Ranko, Musil, Vera, Šalaj Sanja, Sović, Slavica, Vočanec, Dorja, Baretić, Maja, Jelaković, Ana, Josipović, Josipa, Kos, Jelena, Pećin, Ivan, Zeljković Vrkić, Tajana, and Ezzati, Majid
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growth ,development ,children ,adolescents ,urban - Abstract
Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1, 2, 3, 4, 5, 6. Here we used data from 2, 325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was
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- 2023
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22. Chronic Kidney Disease in Rural Population
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Domislović, Marija, Domislović, Viktor, Stevanović, Ranko, Fuček, Mirjana, Dika, Živka, Karanović, Sandra, Kos, Jelena, Jelaković, Ana, Premužić, Vedran, Leko, Ninoslav, Josipović, Josipa, Brzić, Ivan, Željković Vrkić, Tajana, Capak, Krunoslav, Jelaković, Bojan, Domislović, Marija, Domislović, Viktor, Stevanović, Ranko, Fuček, Mirjana, Dika, Živka, Karanović, Sandra, Kos, Jelena, Jelaković, Ana, Premužić, Vedran, Leko, Ninoslav, Josipović, Josipa, Brzić, Ivan, Željković Vrkić, Tajana, Capak, Krunoslav, and Jelaković, Bojan
- Abstract
The aims of the study were to provide data on chronic kidney disease (CKD) prevalence in rural population and to analyze the association with cardiovascular risk factors and aging. A random sample of 2193 farmers (1333 female (F) and 860 male (M), mean age 50.61±17.12) were enrolled. Questionnaire and clinical examination were conducted. Participants provided a spot urine and fasting blood sample. Estimated glomerular filtration rate (eGFR) was estimated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Subjects were classified according to the KDIGO guidelines. The overall prevalence of CKD (eGFR <60 mL/min/1.73 m2) was 8.83% (F vs. M 9.9% vs. 6.3%; p<0.001). Albuminuria (albumin-to-creatinine ratio >30 mg/g) was found in 8.45% (F vs. M p>0.05). Sharp increase in CKD prevalence was found to begin after the sixth decade (29.44% in subjects older than 65 years; F vs. M 30.9% vs. 26.8%; p<0.01). The strongest predictor factors for CKD were age >65 years (OR 22.12), hypertension (OR 6.53), albuminuria (OR 5.71), fasting blood glucose >7 mmol/L (OR 5.49), diabetes (OR 3.07), abdominal obesity (OR 2.05) and non-smoking (OR 0.41). In multivariate analysis, age (OR 1.13), female gender (OR 0.60) and diabetes (OR 1.75) were the independent predictor factors for CKD. In conclusion, CKD prevalence is high in rural population, being higher in women than in men. In both genders, eGFR significantly decreased with aging. Aging is a significant independent predictor of CKD., Cilj ove studije bio je istražiti učestalost kronične bubrežne bolesti (KBB) kod seoskog stanovništva i analizirati povezanost s čimbenicima kardiovaskularnoga rizika i starenjem. U studiju je bilo uključeno 2193 ispitanika (1333 žena, 860 muškaraca, srednja dob 50,61±17,12 godina). Svi ispitanici su ispunili opsežan upitnik i klinički su pregledani. Uzet im je uzorak krvi natašte i drugi jutarnji uzorak mokraće. Procijenjena stopa glomerularne filtracije (eGFR) utvrđena je pomoću jednadžbe CKD-EPI. Ispitanici su klasificirani prema smjernicama KDIGO. Sveukupna učestalost KBB (eGFR <60 mL/ min/1,73 m2) bila je 8,83% (žene prema muškarcima 9,9% prema 6,3%; p<0,001). Albuminurija je potvrđena (omjer albumina i kreatinina (ACR) >30 mg/g) u 8,45% ispitanika bez razlike među spolovima. Učestalost KBB bila je značajno veća kod ispitanika starijih od 65 godina u oba spola (29,44%; žene prema muškarcima 30,9% prema 26,6%; p<0,01). Najjači prediktorski čimbenici za KBB bili su dob >65 godina (OR 22,12), hipertenzija (OR 6,53), albuminurija (OR 5,71), glukoza u krvi natašte >7 mmol/L (OR 5,49), dijabetes (OR 3,07), trbušna pretilost (OR 2,05) i nepušenje (OR 0,41). U multivarijatnoj analizi (OR 1,13) su ženski spol (OR 0,60) i dijabetes (OR 1,75) bili nezavisni prediktorski čimbenici za KBB. U zaključku, učestalost KBB je velika u ruralnoj populaciji. U oba spola eGFR se značajno smanjila starenjem, koje se pokazalo kao značajan nezavisni prediktor za KBB.
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- 2022
23. Frequency of AGT, ACE, AGTR1, ADRB1, UMOD and ADIPOQ genetic polymorphisms in prehypertension
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Šimičević, Livija, Josipović, Josipa, Jelaković, Ana, Miličić, Borna, Đapić, Krešimir, Domislović, Viktor, Ivković, Vanja, Dika, Živka, Gellineo, Lana, Fuček, Mirjana, Lovrić, Jasna, and Jelaković, Bojan
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gene polymorphisms ,etiology ,observational study ,prehypertension ,risk factors - Abstract
Arterial hypertension (AH) is a major independent risk factor for cardiovascular (CV) and cerebral mortality and morbidity and is one of the major risk factors for chronic kidney disease. Prehypertension (PHT) i.e. high normal arterial pressure (AP) is also associated with CV risk and risk of progression in AH. Previous studies of the genetic background of PHT have been insufficiently conducted, and the results indicate a possible association of certain genes involved in the etiopathogenesis of AH and PHT. The lack and sometimes inconsistency of information and results on the role of gene polymorphisms in the etiopathogenesis of PHT were the impetus to this research. Our hypothesis was that polymorphisms rs2004776 AGT, rs1799752 ACE, rs5196 AGTR1, rs1801253 ADRB1, rs13333226 UMOD and rs266729 and rs17300539 ADIPOQ, which are associated with AH and metabolic syndrome, are more common in individuals with high normal AP i.e. prehypertension than in individuals with optimal and normal AP. We chose these polymorphisms because these genes are involved in various mechanisms that lead to an increase in AP and metabolic complications. In this cross-sectional, observational study, 601 subjects were included ; 319 with high normal AP (PHT, 120/80–139/89 mmHg), both sexes, aged 20–45 years, and 282 subjects with normal and optimal AP as a control group (NT). The results showed that the investigated gene polymorphisms are not found more frequently in the PHT group than in the NT. However, a significantly lower frequency of the heterozygous genotype rs266729 ADIPOQ was found in PHT (35.1%), compared to the frequency in NT (44.7%), P = 0.03. The incidence of PHT is 0.66-fold lower in heterozygous (C/G) carriers of rs266729 ADIPOQ. We demonstrated a significant association of the minor allele G rs13333228 UMOD with lower values of systolic and diastolic AP and the minor allele A rs17300539 ADIPOQ with lower values of systolic AP. Additionally, our study resulted in the identification of two haplotypes that were significantly positively associated with PHT formation. The first is hIAGC with a 41% higher probability of developing PHT (rs1799752 ACE + rs13333226 UMOD + rs17300539 ADIPOQ + rs266729 ADIPOQ). The frequency of this haplotype is 8% higher in PHT than in NT. The second haplotype is hIAGCA and is 47% more likely to develop PHT (rs1799752 ACE + rs13333226 UMOD + rs17300539 ADIPOQ + rs266729 ADIPOQ + rs5186 AGTR1). The frequency of hIAGCA in NT is 18%, while in PHT it is 23%. Furthermore, the finding of a model of multivariate prediction of PHT (gene-gene-other determined parameters interaction) which includes a pro-prehypertensive significant effect of male sex, body weight, heart rate, fasting glucose concentration and total cholesterol is significant, while the protective effect within this model have body height and heterozygous (G/A) genotype rs17300539 ADIPOQ. We pointed to the possible importance of genes encoding proteins involved in essential biological pathways responsible for AP control, which include, among others, the renin-angiotensin-aldosterone system, the kidney, the central nervous system, blood vessels, and adipose tissue. In conclusion, the performed analyzes confirmed and showed the presence of significant gene - gene and gene - other determined parameters interactions (anthropometric, biochemical, environmental factors), but also gene - gene - other determined parameters in the etiology of PHT.
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- 2022
24. Kronična bubrežna bolest kod seoskog stanovništva
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Domislović, Marija, Domislović, Viktor, Stevanović, Ranko, Fuček, Mirjana, Dika, Živka, Karanović, Sandra, Kos, Jelena, Jelaković, Ana, Premužić, Vedran, Leko, Ninoslav, Josipović, Josipa, Brzić, Ivan, Željković Vrkić, Tajana, Capak, Krunoslav, and Jelaković, Bojan
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Kronična bubrežna bolest ,Učestalost ,Starenje ,Albuminurija ,Epidemiologija ,General Medicine ,Chronic kidney disease ,Prevalence ,Aging ,Albuminuria ,Epidemiology - Abstract
The aims of the study were to provide data on chronic kidney disease (CKD) prevalence in rural population and to analyze the association with cardiovascular risk factors and aging. A random sample of 2193 farmers (1333 female (F) and 860 male (M), mean age 50.61±17.12) were enrolled. Questionnaire and clinical examination were conducted. Participants provided a spot urine and fasting blood sample. Estimated glomerular filtration rate (eGFR) was estimated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Subjects were classified according to the KDIGO guidelines. The overall prevalence of CKD (eGFR 30 mg/g) was found in 8.45% (F vs. M p>0.05). Sharp increase in CKD prevalence was found to begin after the sixth decade (29.44% in subjects older than 65 years; F vs. M 30.9% vs. 26.8%; p65 years (OR 22.12), hypertension (OR 6.53), albuminuria (OR 5.71), fasting blood glucose >7 mmol/L (OR 5.49), diabetes (OR 3.07), abdominal obesity (OR 2.05) and non-smoking (OR 0.41). In multivariate analysis, age (OR 1.13), female gender (OR 0.60) and diabetes (OR 1.75) were the independent predictor factors for CKD. In conclusion, CKD prevalence is high in rural population, being higher in women than in men. In both genders, eGFR significantly decreased with aging. Aging is a significant independent predictor of CKD., Cilj ove studije bio je istražiti učestalost kronične bubrežne bolesti (KBB) kod seoskog stanovništva i analizirati povezanost s čimbenicima kardiovaskularnoga rizika i starenjem. U studiju je bilo uključeno 2193 ispitanika (1333 žena, 860 muškaraca, srednja dob 50,61±17,12 godina). Svi ispitanici su ispunili opsežan upitnik i klinički su pregledani. Uzet im je uzorak krvi natašte i drugi jutarnji uzorak mokraće. Procijenjena stopa glomerularne filtracije (eGFR) utvrđena je pomoću jednadžbe CKD-EPI. Ispitanici su klasificirani prema smjernicama KDIGO. Sveukupna učestalost KBB (eGFR 30 mg/g) u 8,45% ispitanika bez razlike među spolovima. Učestalost KBB bila je značajno veća kod ispitanika starijih od 65 godina u oba spola (29,44%; žene prema muškarcima 30,9% prema 26,6%; p65 godina (OR 22,12), hipertenzija (OR 6,53), albuminurija (OR 5,71), glukoza u krvi natašte >7 mmol/L (OR 5,49), dijabetes (OR 3,07), trbušna pretilost (OR 2,05) i nepušenje (OR 0,41). U multivarijatnoj analizi (OR 1,13) su ženski spol (OR 0,60) i dijabetes (OR 1,75) bili nezavisni prediktorski čimbenici za KBB. U zaključku, učestalost KBB je velika u ruralnoj populaciji. U oba spola eGFR se značajno smanjila starenjem, koje se pokazalo kao značajan nezavisni prediktor za KBB.
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- 2022
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25. Resistant hypertension after renal infarction in a man with fibromuscular dysplasia
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Bukal, Nikolina, primary, Pekov, Dražen, additional, Penezić, Luka, additional, Jelaković, Bojan, additional, and Dika, Živka, additional
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- 2021
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26. Report of the Croatian registry of native kidney biopsies for year 2019
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Laganović, Mario, Gellineo, Lana, Bulimbašić, Stela, Šulc, Snježana, Škegro, Dinko, Minažek, Marija, Barbić, Jerko, Vrdoljak Margeta, Tea, Bubić, Ivan, Đorđević, Gordana, Vidović, Luka, Altabas, Karmela, Šenjug, Petar, Galešić Ljubanović, Danica, Đogaš, Tina, Glavina Durdov, Merica, Radić, Josipa, Babić, Gordan, Gulin, Marijana, Vojković, Marina, Klarić, Dragan, Nakić, Dario, Kupres, Vlasta, Vuković Brinar, Ivana, Ćorić, Marijana, Šimundić, Tihana, Samardžija, Goran, Josipović, Josipa, Gulin, Tonko, Šefer, Siniša, Fodor, Ljiljana, Čingel, Branislav, Zibar, Lada, Gunjača, Mihaela, Knotek, Mladen, Jeličić, Ivo, Luketin, Mirko, Brković, Tonči, Grbić Pavlović, Petra, Dušević Santini, Danijela, Dika, Živka, and Živko, Marijana
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registry ,renal biopsy ,glomerular disease ,epidemiology - Abstract
This report describes data collected by the Croatian Registry of Renal Biopsies (CRRB) for the year 2019. Patients and methods: nine centers (82%) provided data for 255 native kidney biopsies. We assessed the anthropometric data, data on serum creatinine concentration (sCr), 24 h proteinuria, haematuria, serum albumin level, arterial hypertension, histological diagnosis, and complications after renal biopsy. Results: examined group consisted of 58% males, median age 58 y (18-80 y) and 42% women, median age 57 y (20- 86 y). Males had a more impaired renal function at the time of renal biopsy, nephrotic syndrome, and hypertension. The most prevalent clinical presenta tion were urinary abnormalities (34.9%). Among all biopsy cases, primary glomerular diseases were the most often found histology group (41.5%), and IgA nephropathy was the most frequent diagno sis(47.1%). Among secondary glomerular diseases, pauci-immune glomerulonephritis (PIGN) was most often found (30.9%). The highest proteinuria was observed in minimal change disease and dia betic nephropathy (DN). The highest sCR values were found in membranoproliferative glomerulone phritis (MPGN) and necrotizing vasculitis. Patients with MPGN and DN had the highest blood pressure levels. Conclusion: CRRB provides important data on the epidemiology of biopsy-proven kidney diseases from the whole territory of Croatia.
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- 2021
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27. DIETARY SALT INTAKE IN PREGNANCY AND HYPERTENSIVE PREGNANCY DISORDERS – NARRATIVE REVIEW
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Dika, Živka, Juras, Josip, Vukoja, Ivan, Lovrić, Boris, and Migo, William
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hypertension ,pregnancy ,hypertensive pregnancy disorders ,preeclampsia ,salt - Abstract
Salt is crucial for human health, but it`s excess is associated with the development of many diseases including arterial hypertension which is a major feature of hypertensive pregnancy disorders (HPDs). Maternal nutrition during pregnancy can affect cardiometabolic disease development during pregnancy and later in life, but it can also affect fetal growth and disease development in adulthood. Recent studies suggest that excessive salt intake often combined with low potassium intake throughout pregnancy, can suppress renin- angiotensin-aldosterone system (RAAS) with adverse effects on fetoplacental development and can increase the risk of HPDs. Although salt restriction has been considered potentially harmful in the non pharmacological treatment of arterial hypertension in pregnancy and current guidelines do not recommend it during pregnancy to prevent HPDs, especially gestational hypertension and the development of preeclampsia, its role should be reconsidered in light of the recent evidence. However, one key question remains: How much salt, upper and lower limit of daily intake, in a balanced diet is not harmful in uncomplicated pregnancies as well as HPDs in general?
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- 2021
28. Konsenzus Hrvatskoga društva za hipertenziju i Hrvatskoga društva za bubreg Hrvatskog liječničkog zbora o interpretaciji nalaza kontinuiranog mjerenja arterijskog tlaka
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Karanović, Sandra, Dika, Živka, Gellineo, Lana, Jelaković, Ana, Kos, Jelena, Željković Vrkić, Tajana, Živko, Marijana, Gojak, Katica, Premužić, Vedran, Bašić Jukić, Nikolina, and Jelaković Bojan
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arterijska hipertenzija ,kontinuirano mjerenje arterijskog tlaka - Abstract
U cijelom je svijetu arterijska hipertenzija (AH) glavni potencijalno modificirajući čimbenik rizika za pobol i smrtnost. Mjerenje arterijskog tlaka temelj je za postavljanje dijagnoze i liječenje AH-a, a kontinuirano mjerenje arterijskog tlaka (KMAT-a) najinformativnija je od dostupnih metoda i kao takva nezaobilazna u svakodnevnome kliničkom radu. Ovaj dokument, utemeljen na smjernicama Europskoga društva za hipertenziju o kontinuiranome mjerenju arterijskoga tlaka, daje preporuke o pravilnome odabiru uređaja, načinu korištenja, indikacijama za korištenje te interpretaciju nalaza KMAT-a. Radi boljeg razumijevanja svih informacija koje KMAT daje, njihovoga značaja i terapijskih implikacija, svaki od segmenata interpretacije KMAT-a potkrijepljen je kratkim tekstovima s pojašnjenjima i osvrtima na ključne studije.
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- 2021
29. Konsenzus Hrvatskoga društva za hipertenziju o ordinacijskom i kućnom mjerenju arterijskoga tlaka
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Željković Vrkić, Tajana, Dika, Živka, Gellineo, Lana, Jelaković, Ana, Karanović, Sandra, Kos, Jelena, Živko, Marijana, Mihalić, Mirjana, Velkovski, Olgica, and Jelaković, Bojan
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arterijska hipertenzija ,ordinacijsko i izvanordinacijsko mjerenje arterijskog tlaka - Abstract
Mjerenje arterijskoga tlaka temelj je postavljanja dijagnoze arterijske hipertenzije i donošenja odluke o daljnjem pristupu bolesniku. Ordinacijsko mjerenje arterijskog tlaka zlatni je standard i temelj u određivanju stupnja arterijske hipertenzije, a izvanordinacijske metode mjerenja, kućno i kontinuirano, nužne su u prepoznavanju pojedinih oblika arterijske hipertenzije, procjeni kardiovaskularnoga rizika, dugoročnom praćenju bolesnika i titraciji terapije. Hrvatsko društvo za arterijsku hipertenziju, s ciljem olakšavanja i poboljšanja svakodnevnog rada, izradilo je konsenzus-dokument prema uzoru na ove godine objavljen konsenzus dokument Europskog društva za arterijsku hipertenziju.
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- 2021
30. Endemic (Balkan) Nephropathy: A Disease Caused by Aristolochic Acid
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Jelaković, Bojan, primary, Dika, Živka, additional, and Grollman, Arthur P., additional
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- 2012
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31. Berlin Initiative Study 1 equation and HUGE formula for more accurate estimation of kidney function in elderly
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Matašin, Marija, primary, Domislović, Viktor, additional, Fuček, Mirjana, additional, Gellineo, Lana, additional, Jelaković, Ana, additional, Dika, Živka, additional, and Jelaković, Bojan, additional
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- 2021
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32. Repositioning of the global epicentre of non- optimal cholesterol
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Taddei, Cristina, Dika, Živka, Jelaković, Ana, Jelaković, Bojan, and Ezzati, Majid
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lipids (amino acids, peptides, and proteins) ,cholesterol, HDL cholesterol, lipid-related risk, epidemiology - Abstract
High blood cholesterol is typically considered a feature of wealthy western countries. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high- density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1, 127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk— changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non- HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non- optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.
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- 2020
33. The Position of the Croatian Society of Hypertension on the Observed Increase in Risk of Non-melanoma Skin Cancer Associated with Hydrochlorothiazide Treatment
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Jelaković, Bojan, Drenjančević, Ines, Laganović, Mario, Pećin, Ivan, Jelaković, Ana, Baretić, Maja, Dika, Živka, Ivanuša, Mario, Herceg-Čavrak, Vesna, Josipović, Josipa, Kralj, Verica, Leko, Ninoslav, Likić, Robert, Lovrić Benčić, Martina, Orlić, Lidija, Pavlović, Draško, Počanić, Darko, Prkačin, Ingrid, Stevanović, Ranko, Tiljak, Hrvoje, and Željković Vrkić, Tajana
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Hydrochlorothiazide, Non-melanoma Skin Cancer, position paper - Abstract
Upravni odbor Hrvatskoga društva za hipertenziju na svojoj elektroničkoj sjednici održanoj 12. prosinca 2018. raspravljao je o opaženom povećanom riziku za nastanak nemelanomskih karcinoma kože povezanom s liječenjem hidroklorotiazidom i pripremio sljedeće mišljenje. Zaključci 1. Rizik od nemelanomskoga karcinoma kože i usnica veći je u bolesnika liječenih hidroklorotiazidom nego što je u osoba koje nisu liječene ovim lijekom. Rizik se povećava s duljinom trajanja liječenja, tj. s kumulativnom dozom. 2. Mehanizam karcinogenosti hidroklorotiazida temelji se na fotosenzitivnosti. UV zračenje dovodi do disocijacije kloridnoga dijela molekule lijeka, čime se stvara pretpostavka za sintezu slobodnih radikala kisika i posljedično oštećenje molekule DNK. 3. Korist od primjene hidroklorotiazida veća je od rizika. 4. Omjer koristi i rizika napose je veći u starijih i teže bolesnih osoba. 5. Bolesnik mora biti informiran o postojećem riziku. 6. Bolesnik mora biti informiran o postojećoj alternativnoj terapiji koja je na raspolaganju u Hrvatskoj. 7. Svaki liječnik mora u svakoga pojedinog bolesnika procijeniti omjer koristi i rizika te nakon razgovora s bolesnikom odlučiti nastavlja li terapiju hidroklorotiazidom ili se odlučuje za postojeću alternativu. 8. Svim bolesnicima, a napose bolesnicima koji su liječeni hidroklorotiazidom, treba preporučiti uporabu adekvatne fotoprotekcije i redovito provjeravanja pojave ili promjena na koži.
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- 2019
34. INTER-ARM BLOOD PRESSURE DIFFERENCE AND MORTALITY – EPIDEMIOLOGY OF HYPERTENSION IN CROATIA (EHUH STUDY)
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Miličić, Borna, Stevanović, Ranko, Knežević, Tamara, Krtalić, Branimir, Željković Vrkić, Tajana, Kos, Jelena, Đapić, Krešmir, Gellineo, Lana, Domislović, Viktor, Ćatić Ćuti, Edina, Jelaković, Ana, Dika, Živka, Capak, Krunoslav, Jelaković, Bojan, Knotek, Mladen, and Laganović, Mario
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inter-arm blood pressure, mortality, epidemiology, hypertension, ehuh study - Abstract
doi: 10.1097/01.hjh.0000571032.09151.d9
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- 2019
35. OBESITY AND MORTALITY - RESULTS FROM THE EPIDEMIOLOGY OF HYPERTENSION IN CROATIA (EHUH STUDY) - MORTALITY DATA AFTER 17 YEARS OF FOLLOW- UP
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Knezević, Tamara, Stevanović, Ranko, Krtalić, Branimir, Željković Vrkić, Tajana, Kos, Jelena, Pećin, Ivan, Đapić, Krešimir, Domislović, Viktor, Catić Ćuti, Edina, Jelaković, Ana, Dika, Živka, Capak, Krunoslav, Jelaković, Bojan, and Heagerty, Anthony M
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obesity, mortality, hypertension, ehuh study, epidemiology - Abstract
doi: 10.1097/01.hjh.0000571812.61906.90
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- 2019
36. Rising rural body-mass index is the main driver of the global obesity epidemic in adults
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Bixby, Honor, Bentham, James, Zhou, Bin, Di Cesare, Zhou, Paciorek, Christopher J., Bennett, James E., Taddei, Cristina, Stevens, Gretchen A., Rodriguez-Martinez, Andrea, Carrillo-Larco, Rodrigo M., Khang, Young-Ho, Sorić, Maroje, Dika, Živka, Jureša, Vesna, Majer, Marjeta, Mišigoj- Duraković, Marjeta, Musić Milanović, Sanja, Musil, Vera, Ivković, Vanja, Jelaković, Ana, Jelaković, Bojan, Pećin, Ivan, Zeljković Vrkić, Tajana, and Lang Morović, Maja...Ezzati, Majid
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rural ,urban ,BMI - Abstract
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities1, 2. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity3, 4, 5, 6. Here we use 2, 009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017—and more than 80% in some low- and middle-income regions—was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle- income regions. These trends have in turn resulted in a closing—and in some countries reversal—of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low- quality calories.
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- 2019
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37. EPIDEMIOLOGY OF HYPERTENSION IN CROATIA (EHUH STUDY)- MORTALITY DATA AFTER 17 YEARS OF FOLLOW-UP
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Stevanović, Ranko, Knezević, Tamara, Krtalič, Branimir, Željković Vrkić, Tajana, Kos, Jelena, Pećin, Ivan, Đapić, Krešimir, Gellineo, Lana, Domislović, Viktor, Čatić Ćuti, Edina, Jelaković, Ana, Dika, Živka, Capak, Krunoslav, Jelaković, Bojan, and Heagerty, Anthony M
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ehuh study, epidemiology, hypertension, mortality - Abstract
doi: 10.1097/01.hjh.0000571284.77880.15
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- 2019
38. Prehypertension and Cardiometabolic Syndrome
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Fabio Angeli, Katsiki Niki, Thomas Unger Paolo Palatini Stevo Julius Gino Seravalle, Massimo Salvetti James D. H. Goodman, Daan J. L. van Twist, Krzysztof Narkiewicz Raimund Erbel, Dika Živka, Tadic Marijana, Efrain Reisin Alexander H. Kirsch, Gianpaolo Reboldi, Guido Grassi Peter W. de Leeuw, Morse Stephen, Juan Eugenio Ochoa Angeliki Ntineri, Agabiti-Rosei Enrico, Kai Mortensen Hermann Haller, Jacques Blacher Enrico Agabiti-Rosei, Feber Janusz, Grassi Guido, Flávio Danni Fuchs Alan C. Cameron, Dimitrios Tousoulis Thomas Weber, Alexander R. Rosenkranz Celine Dreyfuss-Tubiana, Terentes-Printzios Dimitrios, Bojan Jelaković Professor Stevo Julius’ Scientific Contributions Sandra Costa Fuchs, Dimitri P. Mikhailidis Talma Rosenthal Sadi Gulec, Haloui Mounsif, Moebus Susanne, Rostrup Morten, Claudia Agabiti-Rosei Jonathan Owen, Kupka Brigitte, Lović Dragan, Flávio Danni Fuchs, Stefano Masi Elena Kaschina, George S. Stergiou Uday M. Jadhav, G. Grassi, Lehmann Nils, Wassertheurer Siegfried, Hering Dagmara, McLean Angela, Zbigniew Kułaga Katarzyna Stolarz-Skrzypek, Litwin Mieczysław, Kollias Anastasios, Onkar C. Swami Arno Schmidt-Trucksäss Giacomo Pucci, Karl-Heinz Jöckel G. Seravalle, Michel E. Safar, Rhian M. Touyz Agnieszka Olszanecka, Stang Andreas, Cetin Erol Andrzej Januszewicz, Rossitto Giacomo, Jan Menne Cesare Cuspidi, Carolina De Ciuceis, Herceg-Čavrak Vesna, Laganović Mario, Sandra Costa Fuchs Pavel Hamet, Abraham A. Kroon Damiano Rizzoni, Ivar Eide Ana Jelaković, Danuta Czarnecka Reuven Zimlichman, Giuseppe Mancia Gianfranco Parati, Paolo Verdecchia Arnljot Flaa, Carmel M. McEniery Reza Aghamohammadzadeh, Dario Turturiello, Paini Anna, Hametner Bernhard, Ninian N. Lang, Rosa Maria Bruno, Stahl Klaus, Giuseppe Ambrosio, Danuta Czarnecka Michael Doumas, Ian B. Wilkinson, Anthony M. Heagerty Stefano Taddei, Bertram Anna, Barry van Varik, Porteri Enzo, Pedro Guimarães Cunha Charalambos Vlachopoulos, Churzidse Sofia, Sverre E. Kjeldsen, Johanne Tremblay Jana Brguljan, and Aleksander Prejbisz Stéphane Laurent
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Diabetes mellitus ,Angiography ,Emergency medicine ,medicine ,business ,medicine.disease ,Prehypertension ,Angiology - Published
- 2019
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39. Treatment of Hypertension Induced Albuminuria
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Knežević, Tamara, primary, Gellineo, Lana, additional, Jelaković, Ana, additional, Premužić, Vedran, additional, Dika, Živka, additional, Laganović, Mario, additional, and Jelaković, Bojan, additional
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- 2019
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40. OUTCOME IN ELDERLY PATIENTS WITH ANCA -- ASSOCIATED GLOMERULONEPHRITIS MANAGED WITH IMMUNOSUPPRESSIVE TREATMENT.
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Kurtov, Karlo, Laganović, Mario, Karanović, Sandra, Dika, Živka, Ivandić, Ema, Živko, Marijana, Kos, Jelena, Fištrek, Margareta, Jelaković, Bojan, and Brinar, Ivana Vuković
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- 2021
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41. Fibromuskularna displazija
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Dika, Živka, Abramović, Ivana, Karanović, Sandra, and Jelaković, Bojan
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I fibromuskularna displazija (FMD) ,renovaskularna hipertenzija (RVH) ,spontana disekcija koronarne arterije (SCAD) ,spontana disekcija cervikalne arterije (SCeAD) ,perkutana transluminalna angioplastika (PTA) - Abstract
Fibromuskularna displazija (FMD) rijetka je neaterosklerotična i neupalna vaskularna bolest koja može dovesti do stenoze, okluzije, aneurizme ili disekcije arterije. Uzrok FMD-a i njezina prevalencija u općoj populaciji nisu poznati. Najčešće se pojavljuje u mladih žena, iako se može pojaviti u bilo kojoj životnoj dobi. FMD je opisan u gotovo svim arterijama, ali najčešće zahvaća bubrežne i ekstrakranijalne arterije. Kliničke manifestacije FMD-a variraju i ovise o distribuciji zahvaćenih krvnih žila, tipu i težini vaskularne lezije (stenoza različitog stupnja, arterijska disekcija, arterijska aneurizma). U kliničkome tijeku FMD može progredirati tako da zahvaća nove krvne žile ili da na mjestu postojeće lezije dođe do suženja ili stvaranja aneurizmi pa i arteriovenskih fistula. Dijagnoza i klasifikacija FMDa ponajprije se temelji na slikovnim metodama. CT-angiografija (CTA), manje MR-angiografija (MRA), preporučuju se kao probirni i potvrdni test za FMD, dok je digitalna supstrakcijska angiografija (DSA) „zlatni standard“ za određivanje vrste i stupnja promjena i potvrdni test kod nejasnih slučajeva. Prema angiografskoj FMD-klasifikaciji razlikuju se dva tipa lezija: multifokalni („izgled biserne ogrlice“) i unifokalni. Liječenje bolesnika s FMD- om ovisi o naravi i lokalizaciji vaskularnih lezija, prisutnosti i težini simptoma, prethodnim vaskularnim događajima vezanim uz FMD, prisutnosti i veličini aneurizme i komorbiditetima. Liječenje može uključivati medikamentnu terapiju i praćenje ; endovaskularnu terapiju za stenozu (angioplastika bez proširnice, rijetko s proširnicom), disekciju (proširnicom) ili aneurizme (zavojnicama, proširnicom/ama) ; ili kirurško liječenje. U slučaju hemodinamički znatnoga renovaskularnoga FMD-a, metoda izbora je revaskularizacija perkutanom transluminalnom angioplastikom bubrežne arterije (PTRA) balonom. Nakon PTRA-e nužno je redovito pratiti bolesnike zbog rizika za restenozu.
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- 2018
42. Fixed dose combination therapy is associated with better blood pressure control and lower albuminuria in real- life cohort during 7 years of follow up. ENAH – Croatian rural study
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Jelaković, Ana, Abramović, Mirta, Dika, Živka, Domislović, Viktor, Đapić, Krešimir, Fuček, Mirjana, Gelineo, Lana, Josipović, Josipa, Karanović, Sandra, Kos, Jelena, Leko, Nino, Matijević, Vesna, Premužić, Vedran, Vuković Brinar, Ivana, Jelakovic, Bojan, and Heagerty, Anthony M
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fixed dose combination therapy ,blood pressure control ,albuminuria ,enah study - Abstract
Objective: The aim of this study was to analyze differences in blood pressure (BP) control and albuminuria between subjects treated with fixed dose combination (FCD) and those treated with free components in real-life during the 7 years follow up period. Design and method: Out of 1134 subjects (door-to-door enrollment, participation rate 80%) data on 236 (54 men ; 182 women ; mena age 63.2 years) treated hypertensives (HT) were analyzed at the end of 7 years of follow-up. At enter 136 of them were already treated HT (group A) and 100 were new-diagnosed HT (group B) who had started with antihypertensive therapy from that moment. Local GP were allowed to tailor antihypertensive therapy during the follow up period. At basal and at the end of follow up BP was measured by physicians who were project collaborators (ESH/ESC guidelines ; OmronM6) ; salt intake (spot urine - Kawasaki equation), eGFR (CKD-Epi) and albumin-to- creatinin ration (ACR mg/g ; first morning urine sample) were analyzed in central lab. Pregnant women, terminal ill, bed-ridden patients, those with severe disability, mentally ill or suffering from dementia or at least one limb amputated/immobilized were exclided. Results: At the end of follow up BP controll was achieved in 31.6% and 38% of HT (group A and B, respectively). In both groups, there there were no significnat differences in salt intake, BMI, smoking and the number of used drugs between controlled and uncontrolled subjects (p < 0.05). However, in group A significant increase in FDC prescription was observed ih the controlled vs.uncontrolled subjects (22% vs. 5.5%). BP control was associated with lower ACR in group A (14.9 vs.76.3 ; p < 0.01) and group B (9.1 vs.24.9 ; p < 0.05). Conclusions: In this real-life cohort after 7 years of follow- up BP controll was ahived with more drugs but only if used as FDC what was associated with better organoprotection i.e.lower ACR. Overall poor BP control and organoprotection could be improved using more FDC.
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- 2018
43. Arterial Stiffness in Balkan Endemic Nephropathy, an Environmental Form of Aristolochic Acid Nephropathy
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Premužić, Vedran, primary, Ivković, Vanja, additional, Leko, Ninoslav, additional, Stipančić, Želimir, additional, Karanović, Sandra, additional, Jelaković, Ana, additional, Vuković Brinar, Ivana, additional, Dika, Živka, additional, and Jelaković, Bojan, additional
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- 2018
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44. Utjecaj urične kiseline na arterijski tlak i vaskularnu funkciju kod mladih odraslih muškaraca rođenih nakon intrauterinog zastoja u rastu
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Laganović, Mario, Vrkić Kirhmajer, Majda, Vrkić Željković, Tajana, Brinar Vuković, Ivana, Karanović, Sandra, Dika, Živka, Premužić, Vedran, Rogić, Dunja, Banfić, Ljiljana, and Jelaković, Bojan
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intrauterini zastoj rasta, arterijska hipertenzija, vaskularna funkcija, urična kiselina - Abstract
Uvod: Premda je poznato da osobe rođene nakon intrauterinog zastoja u rastu (IUGR) imaju veću incidenciju kardiovaskularnih bolesti kasnije u životu, mehanizmi koji to posreduju nisu do kraja poznati. Epidemiološki podaci pokazuju da povišena razina urične kiseline (UK) u serumu korelira s vaskularnom disfunkcijom i hipertenzijom.1-3 Cilj ovog rada je bio istražiti utječe li razina urične kiseline na arterijski tlak (AT) i vaskularnu funkciju u mladih muškaraca rođenih nakon IUGR. Pacijenti i metode: Uključeno je 95 zdravih muškaraca (21, 0 + 0, 89 godina) rođenih ispod 10. percentile porodne težine za gestacijsku dob (SGA) i 90 zdravih muškaraca (21, 5 + 1, 02 godina) s normalnim intrauterinim razvojem (AGA). Podaci o trudnoći i porodu dobiveni su iz registara poroda. Antropometrijski parametri, ambulantni i 24h arterijski tlak (AT), glukoza na tašte, profil lipida, eGFR, debljina intime-medije karotide (cIMT), brzina širenja pulsnog vala (PWV), centralni arterijski tlak (cAT) kao i indeks augmentacije (Aix) izmjereni su kod svih sudionika. Hiperuricemija je definirana vrijednostima UK > 360 µmol/L. Rezultati: SGA ispitanici su imali više vrijednosti UK u usporedbi s AGA grupom (406 vs. 307 p < 0, 001). SGA ispitanici s hiperuricemijom su imali viši indeks tjelesne mase (BMI), opseg struka (p < 0, 003), ambulantni sistolički AT (p = 0, 021), cAT (p = 0, 022), veću varijabilnost AT (p = 0, 021), nižu eGFR (p = 0, 021), kao i češće dislipidemiju (p < 0, 001) što nije bilo nađenoj kod kontrolne skupine. Nije bilo razlike u cIMT, Aix, PWV između skupina. Utvrđena je pozitivna korelacija između UK i BMI, OS kod obje skupine, te negativna korelacija s eGFR (p < 0, 001) u SGA skupini. Kod SGA ispitanika koji su prerano rođeni UK je pozitivno korelirala s varijabilnosti AT (p = 0, 003), cIMT (p = 0, 016) i negativno s porodnom težinom (p = 0, 009). U multiploj regresijskoj analizi BMI se pokazao kao ključna odrednica sistoličkog AT (ß = 0, 427 ; p < 0, 001). Zaključak: Naši rezultati potvrđuju grupiranje KV čimbenika rizika kod mladih odraslih muškaraca s povišenom razinom UK rođenih nakon IUGR. Nisu ustanovljene razlike u vaskularnoj funkciji prema vrijednostima UK. Međutim, kod osoba rođenih nakon IUGR primjećene su subkliničke promjene u karakteristikama AT, uglavnom u visini i povećanoj varijabilnosti sistoličkog AT, što još više dolazi do izražaja u prerano rođenih IUGR osoba. Navedeno može dijelom biti posljedica pojačane vazokonstrikcije kod IUGR ispitanika s povišenom razinom UK.
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- 2017
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45. PREHYPERTENSION AND SINGLE NUCLEOTIDE POLYMORPHISM RS13333226 OF THE UROMODULIN (UMOD) GENE
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Domislović, Viktor, Đapić, Krešimir, Šimičević, Livija, Željković Vrkić, Tajana, Josipović, Josipa, Laganović, Mario, Fuček, Mirjana, Rogić, Dunja, Sertić, Jadranka, Jelaković, Ana, Dika, Živka, Kos, Jelena, Karanović, Sandra, Vuković Brinar, Ivana, Gellineo, Lana, Jelaković, Bojan, and Heagerty, Anthony M
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prehypertension, single nucleotide polymorphism, polymorphism rs13333226 uromodulin (umod) gene - Abstract
doi: 10.1097/01.hjh.0000523999.98833.c4
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- 2017
46. Endemska nefropatija – primjer kasnijeg vaskularnog starenja
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Premužić, Vedran, Leko, Ninoslav, Stipančić, Želimir, Ivković, Vanja, Teskera, Tomislav, Karanović, Sandra, Vuković Brinar, Ivana, Dika, Živka, Laganović, Mario, and Jelaković, Bojan
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krutost arterija, vaskularno starenje, endemska nefropatija - Abstract
Uvod: Bolesnici s terminalnim bubrežnim zatajenjem najčešće umiru od kardiovaskularnih (KV) incidenata, što je najčešće povezano s povišenom krutosti arterija (KA). Osim dobi, KA je snažno povezana u bolesnika s kroničnom bubrežnom bolesti (KBB) s regulacijom homeostaze kalcija i fosfata. Endemska nefropatija (EN) je kronična tubulointersticijska nefropatija karakterizirana kasnijim nastankom arterijske hipertenzije (AH) što utječe na vrijednost KA. Cilj rada je bio analizirati i usporediti ukupnu i KV smrtnost u EN bolesnika s drugim bolesnicima s terminalnim bubrežnim zatajenjem na hemodijalizi. Pacijenti i metode: Uključeno je ukupno 186 hemodijaliziranih bolesnika (90 muškaraca, 96 žena ; 67, 35 + 13, 07 godina) iz tri dijalizna centra u dva endemska područja. Učinjena su kontrolna mjerenja nakon 25 mjeseci na 97 preživjelih bolesnika (52 EN i 45 ne-EN) liječenih kroničnom hemodijalizom, 28 EN i 37 ne-EN bolesnika je umrlo (31 % vs. 39 % ; p = 0, 29) od različitih uzroka. Brahijalni arterijski tlak (AT) je bio mjeren pomoću Omron M6 uređaja, a markeri KA ; brzina pulsnog vala (PWV) i augmentacijski indeks (Aix) Arteriographom prije početka srednje dijalize u tjednu. Rezultati: Nismo pronašli razlika u spolu, pušenju, vrsti vaskularnog pristupa, dozi vezača fosfata, vitamina D, AH i brahijalnog AT između dvije skupine ispitanika. Nije bilo razlika u modalitetu dijalize osim nižim dozama ultrafiltracije u EN bolesnika (p < 0, 001) na početku i na kraju praćenja. EN bolesnici su bili značajno stariji (72, 0 ± 37, 1 vs. 62, 8 ± 15, 1 ; p < 0, 001) s kasnijim započimanjem dijalize na početku i na kraju praćenja. EN bolesnici su imali niže vrijednosti fosfata (1, 36 ± 0, 46 vs. 1, 6 1 ± 0, 42 ; p < 0, 001), umnoška Ca x P (3, 11 ± 1, 13 vs. 3, 76 ± 1, 19 ; p < 0, 001) te iPTH (10, 4 IQ 4, 5-19, 6 vs. 20, 2 IQ 12-50 ; p < 0, 001) i značajno niže vrijednosti PWV-a (9, 2 ± 1, 6 vs.10, 5 ± 1, 9 na početku ; 9, 3 ± 1, 3 vs.10, 5 ± 1, 9 kraj praćenja ; svi p < 0, 001). EN bolesnici su imali kraće trajanje AH prije započimanja hemodijalizom u odnosu na ne-EN bolesnike(36 (12-84) vs. 84 (60- 120) mjeseci ; p < 0, 001). Ne-EN bolesnici su umirali značajno češće od KV incidenata (32 % vs. 12 % ; p = 0, 001). Srednje vrijeme preživljenja je bilo značajno duže u EN skupini bolesnika (22, 3 (95 % CI 21, 2-23.5) vs. 18.2 (95% CI 16, 4-20.0) mjeseci ; p < 0.001). KV smrtnost je bila niža u EN skupini bolesnika (15, 0 % vs. 37, 8 %, HR 0.32 [0.18 - 0.59] ; log-rank p = 0, 0004). Zaključak: EN bolesnici unatoč tome što su značajno stariji su imali niže vrijednosti PWV-a. Endemska nefropatija je nezavisan prediktor niže KA koja se razvija sporije zbog nižih vrijednosti AT, blaže AH u preterminalnim stadijima bolesti, boljoj kontroli AH tijekom hemodijalize i boljoj regulaciji kalcija i fosfata što značajno pridonosi sporijoj progresiji bubrežne bolesti i nižoj KV smrtnosti u ovoj skupini bolesnika.
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- 2017
47. BOLESNIK S HEPATITISOM C I MEMBRANSKOM NEFROPATIJOM
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Željković-Vrkić, Tajana, Laganović, Mario, Dika, Živka, Kos, Jelena, Fištrek-Prlić, Margareta, Premužić, Vedran, Živko, Marijana, Karanović, Sandra, Vuković-Brinar, Ivana, Jelaković, Ana, Ivandić, Ema, Ivković, Vanja, Jelaković, Bojan, Knotek, Mladen, and Laganović, Mario
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hepatitis C, membranska nefropatija - Abstract
Prikaza bolesnik s korničnim hepatitsom C i mišićnom distrofijom koji je razvio membransku nefropatiju
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- 2017
48. BIOPSIJA BUBREGA POD KONTROLOM MSCT-A – METODA IZBORA U KOMPLICIRANIM SLUČAJEVIMA
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Ivandić, Ema, Laganović. Mario, Novosel, Luka, Dika, Živka, Fodor, Ljiljana, Živko, Marijana, Željković-Vrkić, Tajana, Vuković-Brinar, Ivana, Fištrek-Prlić, Margareta, Jelaković, Ana, Jelaković, Bojan, Knotek, Mladen, and Laganović, Mario
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MSCT vođena biopsija bubrega, biopsija bubrega - Abstract
Prikaz MSCT vođenih biopsija bubrega u jednom centru
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- 2017
49. RIJETKE NASLJEDNE HEMATOLOŠKE BOLESTI U PACIJENTICE S POLICISTIČNOM BOLESTI BUBREGA – PRIKAZ SLUČAJA
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Dika, Živka, Živko, Marijana, Željković Vrkić, Tajana, Knežević, Tamara, Gellineo Lana, Jelaković, Bojan, Knotek, Mladen, and Laganović, Mario
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policistična bolest bubrega - Abstract
Opisan je slučaj pacijentice s autosomno dominatnom bolesti bubrega, nasljednom sferocitozom i trombofilijom.
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- 2017
50. UČINKOVITOST EVEROLIMUSA U SMANJENJU BUBREŽNIH ANGIOMIOLIPOMA U BOLESNICE S TUBEROZNOM SKLEROZOM – PRIKAZ SLUĆAJA
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Laganović, Mario, Željković-Vrkić, Tajana, Dika, Živka, Živko, Marijana, Karanović, Sandra, Fištrek-Prlić, Margareta, Kovačević-Vojtušek, Ivana, Jelaković, Bojan, Knotek, Mladen, and Laganović, Mario
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tuberozna skleroza, everolimus - Abstract
prikaz pacijentica oboljele od tuberozne skleroze liječene everolimusom
- Published
- 2017
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