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Due to the large scale use of asbestos (more than 3.5 million tons produced or imported until its definitive banning in 1992), a specific national surveillance system of mesothelioma incident cases is active in Italy, with direct and individual anamnestic etiological investigation. In the period between 1993 and 2004, a case-list of 8,868 pleural MM was recorded by the Italian National Register (ReNaM) and the modalities of exposure to asbestos fibres have been investigated for 6,603 of them. Standardized incidence rates are 3.49 (per 100,000 inhabitants) for men and 1.25 for women, with a wide regional variability. Occupational asbestos exposure was in 69.3% of interviewed subjects (N = 4,577 cases), while 4.4% was due to cohabitation with someone (generally, the husband) occupationally exposed, 4.7% by environmental exposure from living near a contamination source and 1.6% during a leisure activity. In the male group, 81.5% of interviewed subjects exhibit an occupational exposure. In the exposed workers, the median year of first exposure was 1957, and mean latency was 43.7 years. The analysis of exposures by industrial sector focuses on a decreasing trend for those traditionally signaled as "at risk" (asbestos-cement industry, shipbuilding and repair and railway carriages maintenance) and an increasing trend for the building construction sector. The systematic mesothelioma surveillance system is relevant for the prevention of the disease and for supporting an efficient compensation system. The existing experience on all-too-predictable asbestos effects should be transferred to developing countries where asbestos use is spreading.

A dynamic simulation study in TRNSYS environment has been carried out to evaluate energy and economic performance of a novel heating and cooling system based on the coupling between a low or medium-enthalpy geothermal source and an Air Handling Unit, including a Desiccant Wheel. During summer season, a Downhole Heat Exchanger supplies heat to regenerate the desiccant material, while a certain amount of geothermal fluid is continuously extracted by the well in order to maintain high operating temperatures. Simultaneously, the extracted geothermal fluid drives an absorption chiller, producing chilled water to the cooling coil of the Air Handling Unit. Conversely, during the winter season, geothermal energy is used to cover a certain amount of the space heating demand. In both summer and winter operation modes, a geothermal energy is also used to supply Domestic Hot Water. A case study was analyzed, in which an existing low-enthalpy geothermal well (96 °C), located in Ischia (an island close to Naples, Southern Italy), is used to drive the geothermal system. Results showed that the performance of the proposed system is significantly affected by the utilization factor of Domestic Hot Water. In fact, considering a range of variation of such parameter between 5% and 100%, Primary Energy Saving increase from 77% to 95% and Pay-Back Period decreases from 14 years to 1.2 years, respectively. The simulations proved the technical and economic viability of the proposed system. In fact, a comparison with similar systems available in literature pointed out that the layout proposed in this work is characterized by better energy and economic performance, especially in the best scenario. Finally, a sensitivity analysis showed that the system performance is mainly affected by the nominal geothermal flow rate and by natural gas cost.