45 results on '"Dietzsch S"'
Search Results
2. Aktuelle therapeutische Ansätze bei ZNS-Tumoren
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Rutkowski, S., Mynarek, M., Milde, T., Dietzsch, S., and Kortmann, R. D.
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- 2021
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3. Neue Entwicklungen in der pädiatrischen Radioonkologie
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Dieckmann, K., Dietzsch, S., Timmermann, B., and Kortmann, R.
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- 2021
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4. Radiotherapy Quality Assurance in SIOP Ependymoma II – Experiences from Germany, Austria and Switzerland
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Merta, J., primary, Jakob, K., additional, Lin, Y.L., additional, Kramer, P.H., additional, Plaude, S., additional, Behrends, C., additional, Stickan-Verfürth, M., additional, Geismar, D., additional, Mynarek, M., additional, Dietzsch, S., additional, Kortmann, R.D., additional, Benesch, M., additional, Gerber, N., additional, Rutkowski, S., additional, and Timmermann, B., additional
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- 2022
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5. Impact of indication-shift of primary and adjuvant chemo radiation in advanced laryngeal and hypopharyngeal squamous cell carcinoma
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Boehm, A., Lindner, F., Wichmann, G., Bauer, U., Wittekind, C., Knoedler, M., Lordick, F., Dietzsch, S., Scholz, M., Kortmann, R., and Dietz, A.
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- 2015
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6. Schädelbasismetastasen mit Hirnnervenaffektionen
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Hoppe, J., primary, Kalckreuth, T., additional, Metelmann, M., additional, Rumpf, J. J., additional, Klagges, S., additional, Dietzsch, S., additional, Scherlach, C., additional, Kuhnt, T., additional, Kortmann, R. D., additional, and Seidel, C., additional
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- 2022
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7. Multimodaler Larynxerhalt: Wege zur besseren Patientenselektion
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Dietz, A., Boehm, A., Wichmann, G., Niederwieser, D., Dietzsch, S., and Fuchs, M.
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- 2012
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8. MALT-Lymphom des Larynx bei bekanntem Sjögren-Syndrom
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Fischer, M., Horn, I.-S., Bertolini, J., Dietzsch, S., Fuchs, M., and Dietz, A.
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- 2011
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9. Abweichungen der Risikoorgankonturierung und deren Einfluss auf die dokumentierten Organdosen bei kraniospinaler Bestrahlung mit Tumorbett-Boost : Pilotstudie aus dem SIOPE-PNET-5 MB-Protokoll
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Dietzsch, S., Remmele, J., Kitzing, R., Timmermann, Beate, Jablonska, K., Vlad, J., Schwarz, R., Matuschek, C., Grannaß, Andreas, Lewitzki, V., Valentini, C., Rutkowski, S., and Kortmann, R. D.
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Medizin - Published
- 2018
10. Heat- and 4-hydroperoxy-ifosfamide-induced apoptosis in B cell precursor leukaemias
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U Banning, Dietzsch S, Ralf-Bodo Tröbs, Christine Mauz-Körholz, and Dieter Körholz
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Hyperthermia ,Cancer Research ,Programmed cell death ,Hot Temperature ,Physiology ,medicine.medical_treatment ,Antineoplastic Agents ,Apoptosis ,chemistry.chemical_compound ,Cell Line, Tumor ,Physiology (medical) ,Acute lymphocytic leukemia ,Leukemia, B-Cell ,medicine ,Humans ,Ifosfamide ,B cell ,Chemotherapy ,business.industry ,Intracellular Membranes ,medicine.disease ,Nitrogen mustard ,medicine.anatomical_structure ,chemistry ,Caspases ,Immunology ,Cancer research ,business ,Precancerous Conditions ,medicine.drug - Abstract
In the group of high risk childhood acute lymphoblastic leukaemia (ALL), very early and early relapses have a very poor prognosis with conventional chemotherapy alone. Remission induction in these patients is often hindered by drug resistance. Thus, intensifying chemotherapy strategies are required. Application of hyperthermia enhances efficacy of certain anti-neoplastic drugs such as ifosfamide. In this study, effects and molecular mechanisms of ifosfamide - and hyperthermia-induced apoptosis are investigated in a B cell precursor leukaemia cell line (REH) and in primary patient-derived B cell progenitor leukaemic blasts. Both 4OOH-IFA and hyperthermia are able to induce cell death in leukaemic cells, mainly by induction of caspase-dependent apoptosis. However, completely different kinetics of caspase-3, -8 and -9 activation are found for both stimuli. In addition, activation of caspase-1 is only observed following stimulation with hyperthermia. Combined application of ifosfamide and hyperthermia reveals increased cytotoxicity in both the leukaemia cell line and in 5/8 of the patient-derived leukaemic blast samples. In conclusion, hyperthermia and ifosfamide mediate cytotoxicity in B precursor leukaemic blasts by different kinetics of caspase activation. This might explain the additive effects of 4OOH-IFA and heat on leukaemic cell death. Therefore, whole body thermochemotherapy could be considered as a treatment option in relapsed leukaemic patients.
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- 2003
11. Impact of indication-shift of primary and adjuvant chemo radiation in advanced laryngeal and hypopharyngeal squamous cell carcinoma
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Boehm, A., primary, Lindner, F., additional, Wichmann, G., additional, Bauer, U., additional, Wittekind, C., additional, Knoedler, M., additional, Lordick, F., additional, Dietzsch, S., additional, Scholz, M., additional, Kortmann, R., additional, and Dietz, A., additional
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- 2014
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12. Zervikales CUP-Syndrom
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Mozet, C., primary, Wichmann, G., additional, Stumpp, P., additional, Dietzsch, S., additional, and Dietz, A., additional
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- 2012
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13. Multimodaler Larynxerhalt
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Dietz, A., primary, Boehm, A., additional, Wichmann, G., additional, Niederwieser, D., additional, Dietzsch, S., additional, and Fuchs, M., additional
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- 2012
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14. Schluckstörungen nach Kopf-Hals-Tumortherapie und die Möglichkeiten der IMRT
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Dietzsch, S., additional, Melzer, R., additional, Boehm, A., additional, Wolf, U., additional, Kortmann, R., additional, and Fuchs, M., additional
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- 2011
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15. MALT-Lymphom des Larynx bei bekanntem Sjögren-Syndrom
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Fischer, M., primary, Horn, I.-S., additional, Bertolini, J., additional, Dietzsch, S., additional, Fuchs, M., additional, and Dietz, A., additional
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- 2010
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16. Heat- and 4-hydroperoxy-ifosfamide-induced apoptosis in B cell precursor leukaemias
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Mauz-Körholz, C., primary, Dietzsch, S., additional, Banning, U., additional, Tröbs, R.-B., additional, and Körholz, D., additional
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- 2003
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17. Intrathecal thyrotropin-releasing hormone therapy of amyotrophic lateral sclerosis
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Stober, T., Schimrigk, K., Dietzsch, S., and Thielen, T.
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- 1985
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18. Zervikales CUP-Syndrom.
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Mozet, C., Wichmann, G., Stumpp, P., Dietzsch, S., and Dietz, A.
- Abstract
Copyright of Der Onkologe is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2013
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19. Mechanisms of hyperthermia- and 4-hydroperoxy-ifosfamide-induced cytotoxicity in T cell leukemia
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Mauz-Körholz C, Dietzsch S, Banning U, Ralf-Bodo Tröbs, and Körholz D
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Enzyme Activation ,Kinetics ,Leukemia, T-Cell ,Caspase 6 ,Cell Death ,Caspase 3 ,Caspases ,Humans ,Drug Synergism ,Hyperthermia, Induced ,Ifosfamide ,Antineoplastic Agents, Alkylating ,Combined Modality Therapy - Abstract
The prognosis of patients with early ALL (acute lymphoblastic leukaemia) relapse is poor with conventional chemotherapy alone. Thus, intensified chemotherapy strategies are required. The application of hyperthermia enhances the efficacy of certain antineoplastic drugs such as ifosfamide. In this study, the effects and molecular mechanisms of ifosfamide (4hydroperoxy-ifosfamide = 4OOH-IFA)- and/or hyperthermia-induced cell death are investigated in CEM cells. Hyperthermia enhanced the efficacy of 4OOH-IFA in a subaddictive manner. Analysis of caspase activation revealed an early hyperthermia-induced stimulation of caspase-3 and -6 directly after the heating pulse, while maximum activation following stimulation with 4OOH-IFA was obtained after 24 hours of culture. The combination of 4OOH-IFA and hyperthermia mediated an overaddictive caspase stimulation directly following the heating phase. At this time also an overaddictive cytotoxic effect was noticed, being mainly responsible for the enhancing effects of hyperthermia on 4OOH-IFA cytotoxicity. In conclusion, hyperthermia enhanced the cytotoxic effect of 4OOH-IFA on CEM cells by stimulation of an early 4OOH-IFA effect. Thus, thermochemotherapy might be considered as an intensifying treatment option in relapsed T cell leukemias.
20. MBCL-11. TIME TO RADIOTHERAPY IMPACTS SURVIVAL IN PEDIATRIC AND ADOLESCENT NON-METASTATIC MEDULLOBLASTOMA TREATED BY UPFRONT RADIOTHERAPY – A REPORT FROM THE HIT 2000 TRIAL
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Dietzsch S, Placzek F, Pietschmann K, von Bueren A, Matuschek C, Glück A, Matthias Guckenberger, Budach V, Welzel J, Pöttgen C, Schmidberger H, and Mynarek M
21. The electron transfer reaction Fe(CN)63−+eFe(CN)64− with two partial charge transfer steps
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Müller, L., primary and Dietzsch, S., additional
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- 1981
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22. The electron transfer reaction Fe(CN) 63−+ eFe(CN) 64− with two partial charge transfer steps
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Müller, L. and Dietzsch, S.
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- 1981
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23. Management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the SIOPE radiotherapy working group
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Geert O. Janssens, Beate Timmermann, Lorenza Gandola, Yasmin Lassen-Ramshad, Henriette Magelssen, Enrica Seravalli, Brian V. Balgobind, Raquel Davila Fajardo, Anne Laprie, Gillian A Whitfield, Patrick Melchior, Rudolf Schwarz, Laetitia Padovani, Barbora Ondrová, Klaus Seiersen, Monica Ramos Albiac, Stefan Dietzsch, Thankamma Ajithkumar, Rolf D. Kortmann, Karin Dieckmann, Tom Boterberg, Delphine Dumont Lecomte, Christian Carrie, Nicola Thorp, Henry Mandeville, Giovanni Scarzello, Claire Alapetite, Stéphanie Bolle, Bianca A.W. Hoeben, Alison Cameron, Marry M. van den Heuvel-Eibrink, Barbara Rombi, Hoeben B.A., Carrie C., Timmermann B., Mandeville H.C., Gandola L., Dieckmann K., Ramos Albiac M., Magelssen H., Lassen-Ramshad Y., Ondrova B., Ajithkumar T., Alapetite C., Balgobind B.V., Bolle S., Cameron A.L., Davila Fajardo R., Dietzsch S., Dumont Lecomte D., van den Heuvel-Eibrink M.M., Kortmann R.D., Laprie A., Melchior P., Padovani L., Rombi B., Scarzello G., Schwarz R., Seiersen K., Seravalli E., Thorp N., Whitfield G.A., Boterberg T., and Janssens G.O.
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Male ,medicine.medical_specialty ,Lordosis ,medicine.medical_treatment ,Medizin ,Kyphosis ,Review ,Scoliosis ,Pediatrics ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,Journal Article ,medicine ,Humans ,Radiotherapy dose ,Child ,conformal radiotherapy, primary ossification vertebral body ,Ossification ,business.industry ,Cancer ,Radiotherapy Dosage ,medicine.disease ,Hypoplasia ,Radiation therapy ,Oncology ,Child, Preschool ,030220 oncology & carcinogenesis ,Radiation Oncology ,Female ,Radiology ,Radiotherapy, Conformal ,medicine.symptom ,business ,Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] - Abstract
Item does not contain fulltext Inhomogeneities in radiotherapy dose distributions covering the vertebrae in children can produce long-term spinal problems, including kyphosis, lordosis, scoliosis, and hypoplasia. In the published literature, many often interrelated variables have been reported to affect the extent of potential radiotherapy damage to the spine. Articles published in the 2D and 3D radiotherapy era instructed radiation oncologists to avoid dose inhomogeneity over growing vertebrae. However, in the present era of highly conformal radiotherapy, steep dose gradients over at-risk structures can be generated and thus less harm is caused to patients. In this report, paediatric radiation oncologists from leading centres in 11 European countries have produced recommendations on how to approach dose coverage for target volumes that are adjacent to vertebrae to minimise the risk of long-term spinal problems. Based on available information, it is advised that homogeneous vertebral radiotherapy doses should be delivered in children who have not yet finished the pubertal growth spurt. If dose fall-off within vertebrae cannot be avoided, acceptable dose gradients for different age groups are detailed here. Vertebral delineation should include all primary ossification centres and growth plates, and therefore include at least the vertebral body and arch. For partial spinal radiotherapy, the number of irradiated vertebrae should be restricted as much as achievable, particularly at the thoracic level in young children (
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- 2019
24. Search for diphoton events with large missing transverse energy in 7 TeV proton-proton collisions with the ATLAS detector
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N. Davidson, M. Uslenghi, Laurent Vacavant, M. Bendel, D. Schouten, J. Cammin, Gideon Bella, P. F. Zema, Wendy Taylor, Giancarlo Spigo, J. Meinhardt, R. Beccherle, Kathleen Whalen, S. Owen, Michel Lefebvre, Marcos Vinicius Silva Oliveira, D. Fassouliotis, Ralf Hertenberger, S. M. Fisher, Paul Laycock, Irakli Minashvili, A. A. Abdelalim, Corrinne Mills, Tapas Sarangi, A. Staude, Danuta Kisielewska, H. J. Burckhart, R. Dankers, Konstantin Toms, Yuri Kulchitsky, Vadim Gratchev, Si Xie, Jacqueline Batley, Manuela Venturi, Xuai Zhuang, Samira Hassani, Nikolai Rusakovich, C. J. Curtis, Gabriele Chiodini, Phillip Allport, Carlo Schiavi, Allan G Clark, Roger Moore, Anna Macchiolo, Kerstin Tackmann, E. Williams, S. Willocq, Marco Fraternali, Thibault Guillemin, C. Da Via, Stefanie Adomeit, S. Mättig, J. Farley, Kevin Varvell, V. Kral, V. A. Gapienko, G. S. Huang, M. Ibbotson, D. Su, J. T. Childers, Evgeniy Khramov, A. Ferretto Parodi, Ole Røhne, Frank Siegert, Judith Katzy, Fred Hartjes, N. D. Brett, S. De Castro, Ian Brock, G. Polesello, Vincent Hedberg, Jan Valenta, D. Traynor, M. Petteni, Yasuyuki Okumura, William Quayle, N. Skvorodnev, Y. B. Pan, O. G. Grebenyuk, Helio Takai, S. Hamilton, Yang Yang, M. Terwort, Massimo Sorbi, J. Garvey, Hans Krüger, William Brooks, M. C. Tamsett, D. Harper, M. Rescigno, V. Chernyatin, M. P. Sanders, Mous Tatarkhanov, Rashid M. Djilkibaev, Hyun-Chul Kim, Bengt Lund-Jensen, Benjamin Kaplan, Jun Wakabayashi, Lidia Smirnova, R. Kowalewski, Yaquan Fang, F. Wicek, Lukasz Zwalinski, Kirill Prokofiev, A. Palma, Reiner Hauser, S. Cuneo, Bruce Gallop, Laurent Chevalier, Tetiana Hryn'ova, Peter Hansen, Hantao Ji, J. D. Dowell, David Berge, N. De Groot, D. Roda Dos Santos, R. E. Hughes-Jones, Hiroshi Sakamoto, J. Petersen, Peter Kodys, Andreas W. W. Ludwig, Charles Taylor, C. Benchouk, M. Karnevskiy, L. Rosselet, M. Cambiaghi, Susumu Oda, A. Pickford, Shuang-Lin Li, O. B. Dogan, B. Sopko, A. I. Kononov, Gordon Watts, Fabienne Ledroit-Guillon, Kyle Cranmer, Claudio Ferretti, Aaron Angerami, J. Lundquist, R. Perrino, Tohru Takeshita, P. J. Clark, Bellisario Esposito, E. Cogneras, Vadim Kantserov, M. Hauschild, N. Boelaert, A. Kocnar, Alejandro Alonso, Mustafa Yilmaz, J. P. Archambault, S. Walch, Giovanni Darbo, K. Nagai, Iskander Ibragimov, Klaus Hamacher, M. D. Ciobotaru, B. Guo, Valerio Dao, Peter Buchholz, G. A. Odino, T. Perez Cavalcanti, Jian Wang, L. Rumyantsev, J. W. Schumacher, Marianna Testa, P. N. Ratoff, B. Auerbach, Tatiana Klioutchnikova, Dilip Jana, R. K. Bock, Stefan Valkar, Rostislav Konoplich, M. Lungwitz, Graeme Stewart, Zdenek Dolezal, J. E. García Navarro, Kerstin Jon-And, L. Xaplanteris, G. Cataldi, M. Sosebee, Jacob Searcy, Massimiliano Bellomo, Borut Paul Kerševan, Arthur Moraes, Barbara Wosiek, D. Joffe, J. Z. Will, Uwe Bratzler, Pierre-Antoine Delsart, S. Vallecorsa, K. Fowler, A. Papadelis, Tancredi Carli, T. Stahl, K. Stevenson, Roberto Cardarelli, Mark Sutton, José Salt, S. Nelson, Abdeslam Hoummada, D. H. Saxon, Laura Jeanty, T. Buran, Markus Elsing, Lee Sawyer, Sally Seidel, Peter Onyisi, Mattias Ellert, M. Losada, Filippo Maria Giorgi, P. M. Tuts, T. Ohsugi, K. H. Hiller, K. Mahboubi, J. Silva, Kiyotomo Kawagoe, Jean-Francois Arguin, D. Urbaniec, A. Vogel, Veysi Erkcan Ozcan, Andreas Petridis, Gianluca Alimonti, Rainer Stamen, T. B. Sjursen, G. Hughes, Urmila Soldevila, Alberto Mengarelli, P. D. Thompson, C. Carpentieri, S. Swedish, M. S. Kayl, M. Kurata, M. Schmitz, Patrick Fassnacht, I. Ludwig, Andrew Pilkington, Christos Anastopoulos, Bianca Osculati, Bobby Samir Acharya, H. A. Neal, P. Ruzicka, C. Cowden, J. Hoffman, M. T. Pérez García-Estañ, G. Bachy, Guillaume Unal, J. T. Linnemann, Andreas Hoecker, A. N. Sisakyan, A. Artamonov, A. V. Larionov, R. C. W. Henderson, M. J. Shochet, Alexandre Rozanov, Edmund Dawe, Claudio Santoni, Y. A. Tikhonov, David Yu, Evgeny Starchenko, M. Mechtel, C. Padilla Aranda, Kate Shaw, Juerg Beringer, A. Jantsch, Mathieu Benoit, K. Bernardet, Nicola Venturi, Yuji Yamazaki, H. Ghazlane, Guosheng Xu, G. Cattani, A. Astbury, C. Cerna, G. Kilvington, L. Micu, Stefan Schlenker, Liron Barak, Alexander Undrus, Tatsuya Masubuchi, E. Rulikowska-Zarebska, Oliver Keith Baker, John Alison, Sara Valentinetti, Frank Winklmeier, L. R. Flores Castillo, S. D. Kolya, Luc Poggioli, Christine Kourkoumelis, Pedro Jorge, Gvantsa Mchedlidze, Sarah Heim, E. van der Poel, Uladzimir Kruchonak, Mauro Iodice, Gideon Alexander, B. Rensch, Cristian Stanescu, P. J. Bell, S. V. Mouraviev, P. Branchini, D. Lopez Mateos, Harald Joerg Stelzer, Massimo Antonelli, Maia Mosidze, J. A. Strong, G. Gorfine, Pavel Shatalov, Jochen Dingfelder, J. R. Keates, Alex Kastanas, R. Froeschl, Alaettin Serhan Mete, B. G. Pope, Robert P. Ely, S. A. Gorokhov, T. Byatt, A. D. Doxiadis, M. Dwuznik, Jolanta Olszowska, Lorne Levinson, K. Yamamoto, Hui Li, J. L. Schlereth, A. Christov, Sigve Haug, N. Austin, Ovsat Abdinov, L. E. Kirsch, M. Perantoni, A. G. Schamov, J. Odier, G. Usai, Joe Kroll, Daniel Lellouch, K. K. Joo, A. Leger, S. Heisterkamp, A. Engl, A. Roe, David Calvet, Mitsuaki Nozaki, M. Tyndel, E. Berglund, Davide Costanzo, M. G. Wilson, J-P. Meyer, A. Guida, G. Carlino, Frank Fiedler, Giovanni Maccarrone, Vaclav Vrba, Francois Touchard, M. I. Pedraza Morales, W. J. Mills, J. Dubbert, Jean-Francois Grivaz, A. Manabe, Janet Dietrich, Martin Hoeferkamp, V. Giangiobbe, Jiri Dolejsi, Alastair Dewhurst, Ulrich Husemann, Heinz Pernegger, Alexander Oh, A. Manousakis-Katsikakis, J. Lesser, N. Grigalashvili, D. Gillberg, S. Mitsui, Rupert Leitner, Leonardo Paolo Rossi, Z. Qian, John H. L. Hansen, P. de Jong, Claudio Luci, S. De Cecco, Trevor Vickey, G. Schuler, Phillip Gutierrez, Y. Rodriguez Garcia, R. Yoshida, Dimitrios Iliadis, A. Taga, Jun Guo, T. J. Brodbeck, Kirika Uchida, Hisaya Kurashige, M. King, Joern Grosse-Knetter, Sergio Grancagnolo, C. Borer, Sabine Crépé-Renaudin, Osamu Sasaki, Carlos Solans, S. George, Miriam Watson, Milos Lokajicek, P. Waller, Steven Ahlen, C. Santamarina Rios, D.P.S. Ferguson, K.M. Smith, F. Mueller, Thorsten Kuhl, Nikolaos Konstantinidis, R. Sandstroem, João Carvalho, S. Lockwitz, C. Bacci, Shuwei Ye, Jennifer A. Love, Alberto Aloisio, A. Nikiforov, Y. Morita, Oleg Brandt, J. Hartert, Mara Senghi Soares, R. J. Miller, B. C. LeGeyt, E. Reinherz-Aronis, Sh. Yamamoto, J. Cook, Dominik Dannheim, Cesare Bini, Zhen Yan, K. Skovpen, Rodney Walker, C. Tsarouchas, S. Gadomski, M. Ugland, T. C. Meyer, A. T. H. Arce, Jamal Eddine Derkaoui, Arno Straessner, C. U. Felzmann, F. Butin, Sébastien Viret, B. Chapleau, Denis Salihagic, B. Jackson, Markus Cristinziani, Wolfgang Liebig, Lourenco Lopes, M. Shimojima, Michael Andrew Parker, Susanne Kuehn, Xifeng Ruan, Johannes Haller, Efstathios Paganis, Maurizio Piccinini, Neil Collins, Edward Diehl, L. Batkova, I. Gough Eschrich, S. Tanaka, M. Corradi, L. Zhao, Monica D'Onofrio, I. Nasteva, Driss Benchekroun, Jos Vermeulen, D. Breton, Konstantinos Nikolopoulos, A. Bruni, Teng Jian Khoo, Kunihiro Nagano, L. Moneta, S. Eckweiler, B. Budick, I. Wilhelm, M. De Oliveira Branco, N. I. Bozhko, D. V. Dedovich, Elizaveta Shabalina, J. Ferland, Andrea Sansoni, J. Poll, G. Ordonez, S. Baker, L. M. Gilbert, G. T. Jones, M. Cirilli, Alison Lister, J. A. Gray, Rinat Fakhrutdinov, E. Spiriti, Stefania Spagnolo, R. Porter, Martine Bosman, H. Nomoto, E. Hazen, Sergio Gonzalez-Sevilla, M. Mikuž, Y. Zolnierowski, E. J. Buis, M. Aurousseau, M. Groh, Lucio Cerrito, Kerstin Lantzsch, Jochen Schieck, C. Belanger-Champagne, T. Del Prete, John Rutherfoord, Massimo Caccia, Holger Schulz, A. Phan, Filippo Ceradini, Krzysztof Korcyl, S. Campana, Martin Maß, S. T. French, C. A. Magrath, R. Schwierz, J. Knobloch, V. M. Romanov, Andrea Catinaccio, Rachel Maria Avramidou, Cigdem Issever, Song-Ming Wang, A. Leung Fook Cheong, Jana Schaarschmidt, I. A. Christidi, N. Ghodbane, D. Kuhn, D. Evangelakou, M. J. Oreglia, H. Wahlen, Stan Bentvelsen, T. Vu Anh, G. Volpini, Stefan Kaiser, Shigeru Odaka, H. von Radziewski, Daniel Muenstermann, I. Massa, A. J. Martin, C. Vellidis, Christophe Clement, J. Weber, Vipul Jain, Dominique Pallin, Rosy Nicolaidou, C. Pizio, Timothy Andeen, C. Grah, Z. Zhan, Jianming Qian, G. Tong, A. Borisov, Vincenzo Canale, W. Iwanski, A. G. Myagkov, L. Duflot, K. Jelen, E. Petit, Andrey Soukharev, A. Hidvegi, B. Nicquevert, A. Bertin, M. Tylmad, Calin Alexa, C. Wright, J. A. Bogaerts, T. N. Addy, Zhijun Liang, F. Bertinelli, Tomas Sykora, Jyothsna Rani Komaragiri, Mark Slater, Valery Schegelsky, F. Garberson, K. E. Johansson, Mark Stockton, Yoichi Ikegami, L. Chikovani, Pavol Strizenec, V. Sopko, V. A. Korotkov, Siegfried Wenig, T. J. Sloan, I. Torchiani, Jovan Mitrevski, Murrough Landon, Peter Jenni, Q. T. Shao, Hongfang Liu, S. Aoun, P. Giusti, J. Sloper, Paul Tipton, Margherita Primavera, A. Do Valle Wemans, M. Kelly, M. Strang, Olivier Arnaez, T. Akdogan, Elliot Lipeles, Saleh Sultansoy, C. Daum, R. Tanaka, T. Göpfert, I. Turk Cakir, Andreas Warburton, M. Ramstedt, M. C. Morone, Kazunori Hanagaki, G. Nanava, M. E. Zeller, E. Sedykh, G. Calderini, Carmen García, J. Lys, F. Föhlisch, Allen Mincer, M. V. Purohit, Uli Schäfer, Dirk L. Hoffmann, Junji Tojo, Ehud Duchovni, A. G. Kholodenko, S. J. Park, Paolo Camarri, Stefan Tapprogge, Mario Lassnig, A. Maio, C. Conta, Ralf P. Richter, Christopher J. Kenney, B. M. Waugh, F. Sarri, A. S. Kozhin, David Francis, Marcello Fanti, J. Colas, A. J. Lowe, A. Boveia, Ki Lie, T. Spreitzer, K. Miyazaki, J. Machado Miguens, Fumihiko Ukegawa, Andrea Formica, Venetios Polychronakos, V. Perez Reale, Yona Oren, R. A. McLaren, Eram Rizvi, L. La Rotonda, I. Hruska, M. Villaplana Perez, R. Herrberg, C. P. Buszello, Stephanie Majewski, Daniel Fournier, P. Yu Nechaeva, Xiaohu Sun, I. Stekl, P. Steinbach, G. M. Kolachev, Marzio Nessi, E. Jankowski, Martin Rybar, A. Seiden, T. Hayakawa, James Catmore, Robert Kehoe, W. E. Cleland, Renat Sadykov, Rudiger Voss, Georges Azuelos, Nick Barlow, Barry King, F. Alessandria, Helena Santos, Ricardo Neves, Fred R. Hirsch, Bertrand Laforge, K. H. Becks, G. Luijckx, David J. Smith, A. Filippas, O. Gutzwiller, M. Della Pietra, S. Gonzalez, Marco Schioppa, I. Jen-La Plante, G. Tzanakos, Andrea Bocci, M. Cooke, B. Sellden, K. K. Temming, Y. F. Ryabov, Nikola Makovec, Dave Charlton, Xiaoqin Li, Hulin Wang, A. Ahmad, Corinne Goy, C. Lapoire, Diane Cinca, Reiner Klingenberg, Helmut Wolters, Vladimir Nikolaenko, Z. Weng, A. Penson, Ian Michael Nugent, Muhammad Alhroob, P. Conde Muiño, Evelina Vassileva Bouhova-Thacker, Eugen Ertel, Georgios Tsipolitis, Sven Menke, A. Lupi, Mogens Dam, Victor Maleev, Karl Jakobs, Xie Yijin, Peter Schacht, Mauro Donegà, M. Jimenez Belenguer, M. Turala, O. Kvasnicka, H. Czirr, Frank Paige, Else Lytken, Charles Leggett, M. Rammes, Fabian Huegging, C. M. Hawkes, A. M. Zaitsev, F. Broggi, T. Mclaughlan, M. Mazzanti, E. De La Cruz-Burelo, J. R.A. Booth, D. Fasching, C. Ruwiedel, Thorsten Wengler, O. C. Jonsson, V. Savinov, Murdock Gilchriese, I. Satsounkevitch, F. Quinonez, Andrea Ventura, Michael Solar, A. Bangert, B. Åsman, M. Klemetti, Oldrich Kepka, F. Cataneo, A. Richards, Ulrich Parzefall, M. Ziolkowski, Alexander Bogdanchikov, Amanda R. Vest, Speranza Falciano, V. Kaushik, T. Meguro, Andreas Redelbach, Farid Ould-Saada, L. De Mora, B. Gosdzik, K. Facius, A. Di Ciaccio, C. Driouichi, Michael A. Strauss, M. Johansen, Voica Radescu, Driss Goujdami, C. Suhr, J. A. Parsons, Stefan Koperny, Julie Kirk, Susanne Kersten, Sebastian Grinstein, R. Ichimiya, Wolfgang Mader, Kendall Reeves, H. Landsman, C. Topfel, B. De Lotto, Emmerich Kneringer, D. van der Ster, Donatella Cavalli, U. Mallik, Mikhail Mineev, John Penwell, P. Hansson, Heiko Lacker, A. Kreisel, J. A. Ernst, F. Etienne, R. Mameghani, G. Lenzen, Dave Britton, Chiara Roda, Børge Kile Gjelsten, A. J. Fowler, James Boyd, D. Romero Maltrana, X. S. Anduaga, A. V. Ivashin, P. Miele, Dimitris Varouchas, Manolis Dris, G. Mahout, Shogo Okada, C. Guicheney, H. J. Yang, Juergen Kroseberg, A. T. Doyle, L. Labarga, B. Gaur, Dominick Olivito, Karel Smolek, Werner Wiedenmann, J. M. Foster, E. Castaneda-Miranda, A. G. Olchevski, Markus Schumacher, Frederic Brochu, Ryszard Stroynowski, T. Doherty, J. R. Lessard, Paul Nilsson, S. Prasad, D. Pomeroy, Alberto Annovi, M. Imhaeuser, Armin Michael Nairz, A. Reinsch, D. Whittington, A. A. Carter, Roger Jones, A. Firan, E. Bergeaas Kuutmann, Are Strandlie, Andrew Brandt, Fernando Marroquim, Frank Seifert, R. Engelmann, M. Wittgen, Ariel Schwartzman, S. Fratina, J. M. Maugain, A. Loginov, Marumi Kado, E. Urkovsky, James Frost, Pier-Olivier Deviveiros, Jonas Strandberg, M. Uhrmacher, A. Beddall, N. Giokaris, Giora Mikenberg, Wouter Verkerke, C. J.W.P. Timmermans, Lixin Ma, D. Typaldos, A. D'Orazio, H. von der Schmitt, E. Valladolid Gallego, X. Espinal Curull, Diego Casadei, Doris Chromek-Burckhart, Tadaaki Isobe, J. N. Lilley, M. Cascella, W. Ji, Tatsumi Koi, Maurice Garcia-Sciveres, V. V. Zmouchko, P. Perus, T. Kobayashi, Petr Andreevich Gorbounov, Torre Wenaus, D. Milstein, Dominic Hirschbuehl, S. Sandvoss, P. Federic, G. A. Chelkov, Alex Martyniuk, Wolfgang Wagner, A. Chilingarov, Marie-Hélène Genest, S. Subramania, O. Vitells, Carsten Hensel, M. Dameri, Luca Fiorini, G. Y. Mitrofanov, Alberto Belloni, M. Leahu, Aldo Saavedra, Atsuhiko Ochi, F. Polci, M. Maaßen, S. Di Luise, James Howarth, Stephen Haywood, Sotirios Vlachos, Walter Lampl, V. Moeller, S. Zenz, J. Inigo-Golfin, David Malon, Stefan Guindon, D. Lumb, B. M. Hawes, E. Dobson, E. Sarkisyan-Grinbaum, Ewa Stanecka, Enrico Tassi, F. Marzano, G. Nunes Hanninger, Jean François Marchand, Jens Dopke, Gokhan Unel, F. Dudziak, Richard Brenner, Marisa Sandhoff, A. Mitra, B. Radics, S. Y. Nesterov, Arely Cortes-Gonzalez, Alexander Milov, A. Irles Quiles, Matthias Klein, Alexey Talyshev, R. Giordano, Vladimir Cindro, Pierre-Hugues Beauchemin, M. Weber, A. Reichold, Konrad Kleinknecht, R. Maenner, Teresa Barillari, V. M. Kotov, Seema Bahinipati, Y. Ilchenko, G. Romeo, Marine Kuna, M. Kenyon, Sara Diglio, Steven Goldfarb, Z. G. Zhao, G. Ciapetti, Peter Loch, W. Mohr, J. B. De Vivie De Regie, Jan Kretzschmar, D. R. Quarrie, E. E. Schmidt, F. Parodi, D. Fellmann, C. C. Young, Anna Kaczmarska, N. Grau, Marina Cobal, A. Tonazzo, David Miller, Jiri Masik, Lawrence Lee, Oleg Fedin, S. Vahsen, W. T. Meyer, Dorothee Schaile, Michael Boehler, Bartosz Mindur, Lianyou Shan, Richard Nisius, Melissa Ridel, C. W. Loh, Jianyong Lu, Srinivasan Rajagopalan, Irene Vichou, Hal Evans, B. A. Dolgoshein, Y. Mahalalel, J. Snow, Ilija Vukotic, Jan Godlewski, M. Rijpstra, Jalal Abdallah, E. Strauss, G. Vegni, C. Schmitt, Erez Etzion, M. Werner, Francois Corriveau, Scott Snyder, Carlos Lacasta, Masaya Ishino, E. Turlay, Elias Coniavitis, K. Mueller, Victor Kukhtin, D. Ludwig, P. Ryan, G. Vandoni, J. Boudreau, P. S. Wells, M. A. Dufour, A. M. Castaneda Hernandez, Chong-Yu Xu, C. Melachrinos, J. Hrivnac, H. Guler, Vladimir Vinogradov, M. A. Wildt, B. Toczek, Gabriel Stoicea, N. Kundu, John Baines, Sergei Chekanov, J. Godfrey, A. Blondel, Pavel Staroba, E. Perez Codina, Giuseppe Costa, Max Baak, K. J. Grahn, Claudio Gatti, Stefan Kluth, J. Fleckner, A. Khomich, M. A. Pleier, Eleni Mountricha, Didier Lacour, Ioannis Nomidis, P. S. Mangeard, Oleg Bulekov, S. Viel, C. Deluca, D. Dzahini, Yueh-Feng Liu, S. Schuh, M. Kaneda, S. Rzaeva, Christoph Amelung, F. G. Oakham, S. Fleischmann, Oxana Smirnova, T. Todorov, T. J. McMahon, Danilo Giugni, V. Rojo, D. S. Damiani, Otmar Biebel, Konstantinos Bachas, F. Varela Rodriguez, Francesco Lanni, O. Gaumer, Aaron James Armbruster, V. Ryadovikov, S. Koenig, R. P. Thun, Giuseppe Iacobucci, Thomas Koffas, Frank Ellinghaus, Arnaud Foussat, R. Mehdiyev, T. Rador, Isabel Marian Trigger, Louise Skinnari, R. J. Homer, Antonio Baroncelli, Ulrich Landgraf, J. Schultes, Mauro Villa, N. Panikashvili, Claire Gwenlan, Vincent Garonne, M. Hohlfeld, X. Portell Bueso, Sandro Palestini, J. Snuverink, R. R. Rios, S. Rodier, I. Dolenc, J. Lellouch, D. Y. Bardin, L. Miralles Verge, E. Auge, R. W. Clifft, G. Brown, Andre Kruth, Julien Donini, Pascal Pralavorio, Ilias Efthymiopoulos, Sandra Kortner, S. Fazio, V. Vorwerk, Vadim Kostyukhin, Lamberto Luminari, M. Shamim, Y. Pylypchenko, Catrin Bernius, Remi Lafaye, Theodota Lagouri, G. Cortiana, Paolo Iengo, M. Marx, S. I. Buda, Hartmut Sadrozinski, K. W. McFarlane, N. Massol, Douglas M. Hawkins, D. S. Popovic, E. L. Barberio, Marco Delmastro, M. Fiascaris, Marina Rotaru, N. Dressnandt, Frédéric Chevallier, H. van der Graaf, S. N. White, Ilya Korolkov, Fridolin Dittus, Y. Munwes, Moritz Backes, Sofia Chouridou, Jason Nielsen, Armen Vartapetian, Maria-Teresa Dova, P. Giovannini, E. Ptacek, Tom McCarthy, M. C. Conidi, Zhiqing Zhang, A. Paoloni, R. Febbraro, M. Warsinsky, M. S. Levitski, E. Laisne, Bernard Aubert, Benjamin Trocmé, M. Moreno Llácer, Bing Li, Shlomit Tarem, Gabriela Navarro, J. Klaiber-Lodewigs, Tiesheng Dai, J. J. Veillet, J. Morel, Guennadi Borissov, Francesco Lacava, M. Tsiakiris, Michael Begel, L. De Nooij, S. Hillert, S. Persembe, M. Saleem, Gustaaf Brooijmans, Dirk-Uwe Bartsch, M. E. Sevior, Gabriella Gaudio, E. Solfaroli Camillocci, C. Del Papa, B. Szeless, K. Perez, P. Stavina, Gerjan Bobbink, Marisilvia Donadelli, Judita Mamuzic, Uta Klein, Maria Smizanska, D. Goldin, D. Imbault, N. Krieger, P. Matricon, M. Abolins, V. N. Goryachev, A. Tonoyan, M. Virchaux, J. A. Wilson, P. V.M. Da Silva, Takahiko Kondo, William Buttinger, S. P. Whitaker, B. M. Salvachua Ferrando, A. Canepa, J. Molina-Perez, I. van Vulpen, Andrzej Zemla, Giulio Aielli, Fernando Barreiro, Itamar Roth, Iacopo Vivarelli, M. Dosil, Xin Wu, Z. Zajacova, Eduardo Ros, Till Eifert, M. I. Gostkin, Per Werner, Simon Head, M. Lichtnecker, E. Oliver Garcia, E. Griesmayer, Shi Liu, Akira Yamamoto, T. Costin, E. I. Rosenberg, C. Dionisi, Paul Miyagawa, Nurcan Ozturk, M. J. Price, R. Marshall, Fr. Pastore, Aziz Chafaq, M. Ackers, George Stavropoulos, K. Randrianarivony, S. Malyukov, Tomas Slavicek, Toyonobu Okuyama, K. Tollefson, M. Kollefrath, Dugan O'Neil, D. Axen, Caroline Collard, Lydia Iconomidou-Fayard, Emmanuel Monnier, S. Yanush, Dj. Sijacki, K. Dindar Yagci, N. Soni, Sophie Henrot-Versille, M. Kuze, J. Alonso, A. Kasmi, S. Migas, S. Zheng, Andrea Knue, Camilla Juul Hansen, Y. Itoh, Amir Farbin, G. Sellers, Miao Liu, Minoru Hirose, A. Dotti, V. V. Lapin, R. Wunstorf, Viktor Kramarenko, Sarah Demers, A. Jeremie, M. He, A. Braem, D. Macina, T. Tic, Adam Trzupek, D. De Pedis, W. Bhimji, V. Rossetti, Iwona Grabowska-Bold, G. Rahal, Abner Soffer, A. Gaponenko, F. Rühr, G. N. Taylor, Pai-hsien Jennifer Hsu, D. Kollar, G. H. A. Viehhauser, Tomas Davidek, F. Dydak, Y. Yao, S. Thoma, Polina Kuzhir, A. Morais, Isabelle Wingerter-Seez, Alessandro Tricoli, P. Lichard, B. Epp, Ann E. Nelson, R. M. Buckingham, A. A. Salnikov, Sandrine Laplace, R. Pengo, C. P. Marino, Vincenzo Izzo, F. Marchese, D. C. Rodriguez, Alexey Maslennikov, F. Anulli, Y. Benhammou, Evgueni Ladygin, Gabriella Pasztor, S. V. Kopikov, Michel Raymond, C. M. Tevlin, T. A. Dietzsch, Bruce Schumm, R. S. B. King, N. Schroer, Serkant Ali Cetin, Margret Fincke-Keeler, Susan Cheatham, Benjamin Ko, P. Haefner, Reda Tafirout, Klaus Kurt Desch, Richard Nickerson, Leonardo Merola, F. Salvatore, Torsten Harenberg, M. Henke, P. Ge, Kathy Pommès, Mark Owen, H. Takeda, Nuno Filipe Castro, Laura Fabbri, Prafulla Kumar Behera, Chariclia Petridou, Iftach Sadeh, B. Fernandes, Jörgen Sjölin, E. Torró Pastor, S. Michal, G. Khoriauli, R. Di Sipio, K. Nakamura, Benjamin Brau, F. Canelli, Nazim Huseynov, Halina Bilokon, Haiping Peng, Emilio Higón-Rodriguez, I. Rubinskiy, Kevin Black, Jean-Francois Laporte, Pamela Ferrari, A. J.M. Muijs, P. Renkel, Christopher Lester, Robert Harrington, Antonio Sbrizzi, Johannes Erdmann, Remi Zaidan, W. Fernando, S. W. O'Neale, A. Coccaro, Andrew White, R. Lifshitz, James W. Bremer, Sw. Banerjee, A. Muir, T. Lari, C. Zeitnitz, S. Caughron, Arnulf Quadt, Michal Vlasak, Lily Asquith, Frank Berghaus, M. J. Kobel, T. W. Jones, Anna Goussiou, Petr Gallus, K. Murakami, R. J. Teuscher, Joaquin Poveda, Timothee Theveneaux-Pelzer, K. Ishii, F. S. Merritt, Lidia Dell'Asta, P. Mättig, S. S.A. Livermore, Ye Zhu, D. Kharchenko, D. M. Seliverstov, R. Placakyte, R. P. Middleton, C. Schroeder, Fabrice Hubaut, M. L. Andrieux, C. Boulahouache, Dario Barberis, L. Lu, Mark Neubauer, V. Lendermann, Philippe Ghez, J. Bouchami, P. Delpierre, F. Bucci, T. Kittelmann, I. Borjanovic, Arnaud Lucotte, B. C. Smith, C. Shaw, Christophe Royon, D. Tsionou, P. J. Magalhaes Martins, S. I. Kazi, V. N. Gushchin, M. Vranjes Milosavljevic, Y. A. Kurochkin, Alexey Zhemchugov, A. Abdesselam, M. I. Scherzer, Kristin Lohwasser, R. Alon, Christopher Potter, H. Ten Kate, B. H. Benedict, Ariella Cattai, T. Kluge, K. Tokunaga, H. Dietl, J. Boek, T. Ohshima, Dmitri Tsybychev, R. L. McCarthy, Vasiliki A Mitsou, Jan Jakubek, S. J. Dallison, G. Rybkin, L. S. Gomez Fajardo, Thomas LeCompte, C. Caso, M. Lehmacher, B. Martin dit Latour, A. Yurkewicz, Woiciech Fedorko, S. Borroni, Stephen Lloyd, D. Arutinov, Francesco Conventi, Evelin Meoni, A. Dahlhoff, Arnaud Ferrari, Y. Hernández Jiménez, A. Di Mattia, Carolina Gabaldon, Stefan Stonjek, Shoji Asai, Jan Strube, Jiangyong Jia, Philippe Mermod, R. Kwee, Kevin Kroeninger, T. Yamamura, M. Consonni, T. Burgess, Frantisek Krejci, E. Badescu, E. Acerbi, F. Hahn, Mark Hodgkinson, J. E.M. Robinson, C. T. Potter, K. Ellis, John Joseph, Sascha Caron, Vladimir Sulin, V. Ferrara, L. Bellagamba, Igor Mandić, S. Carron Montero, G. P. Tappern, D. R. Botterill, Sourav Poddar, Petr Sicho, T. Ince, Naoko Kanaya, Alexandre Vaniachine, F. Cevenini, P. Booth, G. F. Gieraltowski, S. Winkelmann, V. I. Vassilakopoulos, J. E. Brau, E. Brubaker, M. Leltchouk, Christopher Bee, Petr Vokac, Ning Zhou, A. Harvey, V. Bansal, Michael Düren, Tobias Golling, Nicolas Berger, Jiri Chudoba, R. Mackeprang, T. Kohriki, M. Medinnis, J. Virzi, S. Eckert, Raymond Veness, M. J. Kotamäki, Eiliv Lund, Helen Hayward, P. M. Watkins, G. W. Brandenburg, Roberto Spighi, I. Aracena, S. Haas, S. Ask, M. S. Alam, Giuseppe Francesco Tartarelli, R. Santonico, Thomas Lohse, S. König, Liza Mijović, S. H. Robertson, I. Fedorko, S. Behar Harpaz, Dan Pantea, A. Gonidec, J. G. Rocha de Lima, R. Davidson, E. Torrence, M. Leyton, A. Gupta, M. D. Joergensen, Alexander Kupco, Edoardo Gorini, M. Kataoka, M H. Lehto, S. W. Snow, T. K.O. Doan, S. Correard, D. Côté, Aston Komar, R. Duxfield, Y. Silver, B. J. O’Brien, Y. V. Grishkevich, John Stupak, T. Horazdovsky, J. Antos, M. S. Kim, Louis Fayard, Z. Zenonos, Sylvain Tisserant, Wolfgang Walkowiak, I. Rottländer, P. de Saintignon, Metin Arik, G. Chiefari, H. Matsumoto, C. P. Ward, D. della Volpe, Fernando Monticelli, I. Stumer, Peter Krieger, Michel Vetterli, D. Buira-Clark, B. Ruckert, J. de Graat, Heidi Sandaker, A. Ishikawa, Sten Hellman, R. Cherkaoui El Moursli, M. Beimforde, W. Kuykendall, L. Shaver, G. Mirabelli, J. Thadome, Henso Abreu, Matt Dobbs, C. L. Lampen, Norbert Wermes, D. Merkl, R. E. Long, B. Clement, Q. Ouyang, Marjorie Shapiro, Soshi Tsuno, T. Kawamoto, Sara Strandberg, C. Valderanis, R. Piegaia, B. Caron, Stephen Maxfield, T. N. Trinh, C. J. Oram, Cedric Serfon, Stephen Gibson, H. Zhang, Phillip Urquijo, V. I. Kolesnikov, S. E. Allwood-Spiers, Deepak Kar, Jianqiao Ye, Y. Azuma, Petre Dita, Jialun Ping, Torsten Paul Ake Åkesson, A. Gutierrez, Aleandro Nisati, E. Vinek, V. Martinez Outschoorn, G. Rivoltella, A. S. Cerqueira, Mika Huhtinen, Giorgio Bellomo, T. Ženiš, U. K. Yang, Sascha Mehlhase, C. Le Maner, Pedro Urrejola, Beate Heinemann, G. Battistoni, S. Horner, Guido Gagliardi, D. Banfi, K. W. Glitza, P. Strachota, Dave Sankey, S. N. Golovnia, Da Xu, Konstantin Belotskiy, R. Ciftci, Peter Sherwood, A. Polini, Lucio Rossi, Pavel Starovoitov, F. L. Linde, Bernhard Meirose, Carlos Escobar, M. Ahsan, M. A. Alam, Rolf Seuster, S. Rieke, A. Barashkou, G. A. Hare, Y. D. Tennenbaum-Katan, B. Gibbard, Cunfeng Feng, E. O. Ortega, Yasushi Nagasaka, R. J. Hawkings, A. M. Kiver, Tracey Berry, Marco Aurelio Diaz, Tim Martin, L. Živković, Givi Sekhniaidze, S. Wendler, Jing Wang, T. Shin, Dave Robinson, V. Rumiantsev, Juraj Bracinik, Ph Gris, M. J. Losty, V. I. Rud, C. Bourdarios, Jens Weingarten, G. Dedes, U. De Sanctis, Nektarios Benekos, F. Bellina, Peter Vankov, Emmanuel Busato, F. Lo Sterzo, Manuella Vincter, M. Kaci, Chuan-Ming Liu, E. Eisenhandler, P. Kadlecik, Dart-yin Soh, Tristan Beau, Ewelina Lobodzinska, G. Eigen, Yoichi Ninomiya, Anna Lipniacka, Francesco Spanò, P. Cavalleri, A. Henrichs, J. J. Goodson, V. Boldea, Ivan Sykora, S. Nektarijevic, Andrey Kiryunin, Peter Nemethy, P. Johansson, Marc Weber, Katharine Leney, William Trischuk, M. Aderholz, V. Chavda, T. R. McMahon, Shaun Roe, Matthew Beckingham, Sourabh Dube, X. Y. Zhang, Z. Hajduk, B. DeWilde, A. Passeri, N. J. Buchanan, Stefania Xella, B. Brelier, M. Panuskova, Dimitrios Sampsonidis, Imma Riu, A. V. Zenin, O. M. Kind, A. Poblaguev, B. Fatholahzadeh, D. Hill, Toshi Sumida, Kenneth Wraight, D. Wicke, Fr Pastore, A. Tua, P. Grafström, John Hobbs, Naoki Kimura, F. Baltasar Dos Santos Pedrosa, L. Tremblet, Nicolas Morange, David Milstead, Kevin Einsweiler, Tony Liss, Howard Gordon, P. Francavilla, Elisabetta Vilucchi, B. Beare, H. McGlone, A. Di Simone, G. D. Carrillo Montoya, G. Ionescu, B. Martin, A. Gomes, André Schöning, Haleh Khani Hadavand, S. Yu. Sivoklokov, P. Farthouat, O. Krasel, Bruce Barnett, M. A. B. do Vale, Giuseppe Salamanna, K. J. Anderson, Zuzana Rurikova, J. 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Purdham, Reinhard Schwienhorst, M. Zdrazil, Val O'Shea, D. Chakraborty, Bjørn Hallvard Samset, R. D. Kass, Dominik Derendarz, A. E. Nuncio-Quiroz, P. C. Kim, J. Deng, Zdenek Hubacek, C. Mora Herrera, L. A.M. Wiik, Marcello Bindi, F. Gianotti, Marcel Vos, Y. Bai, R. Bartoldus, P. Hurst, D. Eriksson, A. Zaytsev, Ryan Reece, S. Albrand, A. C. Schaffer, Hubert Kroha, O. Gabizon, P. Barrillon, J. Lundberg, T. T. Voss, G. Comune, Richard Mount, George Redlinger, S. Cheng, G. D. Kekelidze, Z. Drásal, Matthew Fisher, J. G. Loken, I. D. Manjavidze, Carsten Meyer, F. F. Martin, Hong Ma, Cheng Guang Zhu, S. L. Cheung, Petr Tas, S. H. Oh, Farkhad Khalil-zada, D. Hayden, B. Van Eijk, Laura Gonella, Alan Poppleton, D. Ventura, Stefano Veneziano, H. O. Ogren, L. Courneyea, Paul Hanke, M. Barisonzi, Hermann Kolanoski, Claus Gössling, Benedetto Gorini, Matthias Schott, M. Pohl, S. Jin, P. Gagnon, Daniel Turecek, P. M. Mockett, Xiaowen Lei, A. B. Lazarev, A. Schreiner, J. W. Dawson, C. 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Bauer, Flera Rizatdinova, T. Sugimoto, John Derek Chapman, W. Kozanecki, S. O. Holmgren, P. G. Bright-Thomas, Martin Goebel, Katsuo Tokushuku, J. Sondericker, E. Brodet, S. Patricelli, T. O. Niinikoski, R. Zitoun, Marcella Capua, E. Rauter, Y. Suzuki, E. Segura, Marc Dobson, Andreas Battaglia, S. Johnert, J. L. Lane, Stephen Burke, S. Sushkov, Giorgi Arabidze, Philip Phillips, Samuel Silverstein, E. Graziani, Ilya Tsukerman, Guenter Duckeck, Michael Flowerdew, Reyhaneh Rezvani, M. Gruwe, H. H. Williams, Antonio Policicchio, D. Sherman, E. van der Kraaij, Sharka Todorova-Nova, T. Sasaki, S. Youssef, Christoph Posch, A. D. Hershenhorn, J. P. Dauvergne, M. Aleppo, C. Biscarat, K. K. Gan, Brian Petersen, Juan Antonio Aguilar-Saavedra, Tamar Djobava, W. H. Bell, L. Di Ciaccio, A. Zsenei, Benjamin Wynne, A. De Salvo, Steinar Stapnes, R. Ueno, L. P. Says, Koji Terashi, Jongmin Lee, A. Antonaki, M. Raas, Craig Buttar, A. P. Vorobiev, R. Bernhard, B. Lundberg, M. Olcese, S. Montesano, D. Greenfield, Michele Livan, Annick Lleres, J. Grognuz, Abbas Kenan Ciftci, Karlheinz Meier, Rui Wang, Josh Moss, Enrique Kajomovitz, C. Handel, J. Almond, J. Nadal, G. Rudolph, M. Schram, Louis Helary, C. Horn, Timothy Barklow, Daria Zieminska, E. Magradze, P. Valente, Andrei Snesarev, J. A. Macana Goia, R. D. Schamberger, C. Lasseur, Ahmimed Ouraou, V. V. Ammosov, Alan Litke, Mieczyslaw Witold Krasny, Yann Coadou, L. K. Gladilin, B. Pinto, Anna Mastroberardino, C. Gong, Bruno Lenzi, T. P. Kokott, Carla Sbarra, Gilbert Poulard, Yuta Takahashi, V. Zutshi, Amanda Cooper-Sarkar, W.J. Willis, S. Schaetzel, Marcin Wladyslaw Wolter, Peter Wienemann, Marek Idzik, D. Rousseau, Nicole Ruckstuhl, O. M. Harris, G. F. Moorhead, Antonio Ereditato, Alexander Grillo, J. E. Sundermann, M. Miñano, Harinder Singh Bawa, Oliver Kortner, C. Zendler, M. Aliyev, Brigitte Vachon, V. Grassi, Peter Sturm, Heather Gray, D. Fortin, O. Pirotte, R. Yoosoofmiya, R. E. Blair, A. Cazzato, A. Kapliy, Riccardo Vari, Jong-Sung Yu, Maria Pilar Casado, G. L. Darlea, W. G. Plano, V. I. Koreshev, J. Walbersloh, K. Benslama, S. Rajek, Robert McPherson, G. L. Glonti, Attila Krasznahorkay, Nicola Semprini-Cesari, H. O. Danielsson, Andrew D. Hamilton, J. Blocki, N. Guttman, T. Cuhadar Donszelmann, R. S. Orr, I. P. Duerdoth, M. V. Gallas, N. J. Cooper-Smith, T. Nishiyama, Igor Gavrilenko, Massimo Lamanna, Y. Gusakov, H. S. Chen, Antonio Limosani, V. O. Tikhomirov, T. Nunnemann, K. Edmonds, R. Di Nardo, Vaclav Vacek, V. Andrei, Dirk Zerwas, Raymond Brock, G. Sauvage, Giovanni Crosetti, Giovanna Bruni, D. R. Hadley, Klaus Mönig, Federica Legger, Valery Khovanskiy, Mihail Chizhov, V. Lombardo, Bruno Mansoulie, Paul Newman, Stanislav Pospisil, Ph. Schune, W-M. Yao, H. Khandanyan, Clara Troncon, Alexei Klimentov, Masaharu Nomachi, Y. Tanaka, B. Stugu, Nigel Hessey, M. Limper, Olga Beltramello, Nicoletta Garelli, J. Yamaoka, Michael R. Wessels, M. Imori, You Zhou, Aranzazu Ruiz-Martinez, Alison Holmes, J. Novakova, P. Zarzhitsky, L. Gauthier, Ricardo Gonçalo, Paul Jackson, G. E. Pospelov, Mihai Ciubancan, V. B. Bobrovnikov, D. A. Forbush, F. Cerutti, Kathryn Grimm, B. Nordkvist, B. D. Cooper, M. Morii, V. Castillo Gimenez, L. Chen, S. H. Kim, A. Renaud, M. Mudrinic, Sergey Kuleshov, M. Nožička, P. Puzo, Yang Gao, Elliott Cheu, T. Henß, G. Jin, A. Bogouch, P. Amaral, Andrea Favareto, M. Gouanère, P. Cwetanski, John Huth, N. Vlasov, M. I. Besana, H. Kiyamura, J. W. Chapman, G. Marchiori, Alexander Khanov, K. Harrison, H. Boterenbrood, H. Kagan, C. D. Cojocaru, A. Siebel, Michael Rijssenbeek, A.S. Vovenko, T. Stockmanns, Gary Boorman, Juan Terron, E. Gornicki, V. J. Guarino, Domizia Orestano, C. Fabre, V. G. Zaets, L. Bugge, Simone Monzani, Avi Gershon, A. Salamon, V. Zhuravlov, J. Coggeshall, Michael Dührssen, K. Tani, F. Georgatos, Richard Bates, C. R. Boddy, V. Juranek, Troels Petersen, S. Dean, K. Kessoku, I. Mussche, N. P. Gollub, S. González de la Hoz, C. Lebel, H. G. Sander, Hans Peter Beck, R. Zimmermann, M. Martinez, J. A. Valls Ferrer, M. L. Kocian, A. V. Pleskach, A. S. Thompson, B. Butler, Thomas Naumann, P. R. Norton, Markus Nordberg, E. Wulf, Dusan Bruncko, Mark Hatch, A. M. Bach, Vakhtang Tsiskaridze, Maria Curatolo, Saminder Dhaliwal, F. Tarrade, G. Akimoto, Riccardo-Maria Bianchi, Paolo Bagnaia, S. Kabana, J. N. Butler, Anyes Taffard, Nuno Anjos, M. Simonyan, A. J. Lankford, D. Prieur, Th. Müller, Joseph Izen, S. Antonelli, John Morris, Antoine Marzin, Juergen Thomas, Nicolas Ellis, Ruslan Mashinistov, Alessandra Ciocio, K. Sliwa, Shinichi Shimizu, L. Han, G. G.G. Massaro, Gen Kawamura, J. Treis, Wim Lavrijsen, Enrico Pasqualucci, V. F. Chepurnov, P. L. Rosendahl, Roberto Ferrari, R. Ishmukhametov, Anna Sfyrla, D. Tardif, Marcella Bona, V. V. Kabachenko, Abdenour Lounis, Ayda Beddall, Nathalie Besson, M. Robinson, Daniel Dobos, A. Cavallari, T. Greenshaw, Andrej Gorišek, Sophie Trincaz-Duvoid, Kazuhiko Hara, T. Frank, C. Dennis, Craig Blocker, A. Barbaro Galtieri, A. Mapelli, Gregor Herten, S. Cabrera Urbán, C. Geweniger, P. K. Mal, D. M. Gingrich, J. Glatzer, Enrico Rossi, H. S. Bansil, R. Calkins, Daniela Salvatore, A. Mayne, I. Orlov, Frank Filthaut, C. Caramarcu, J. Degenhardt, Anne-Isabelle Etienvre, F. Diblen, J. Ferencei, Michael Shupe, L. Lipinsky, G. Alexandre, S. Ventura, Pavel Reznicek, Chiara Meroni, Bruce Yabsley, Deywis Moreno, N. R. Nation, J. Griffiths, M. P. Goulette, Elzbieta Banas, A. Larner, T. Kanno, E. Le Menedeu, Stefan Simion, Serban Constantinescu, Takashi Matsushita, Adele Rimoldi, A. P. Colijn, X. Prudent, S. Kotov, G. A. Cowan, Paul Dervan, L. Köpke, L. V. Kalinovskaya, Darren Price, Fedor Prokoshin, Peter Kluit, R. Caputo, J. E. Pilcher, B. Koblitz, Pierre Savard, Matteo Cavalli-Sforza, T. Hott, Duc Ta, D. Oliveira Damazio, E. E. Kluge, W. Blum, J. Groth-Jensen, V. Gallo, Alevtina Shmeleva, Davide Caforio, Ahmet Bingul, Elzbieta Richter-Was, Michal Marcisovsky, D. R. Rust, Martin Aleksa, Alexandre Lebedev, David Cameron, Shikma Bressler, Regina Moles-Valls, Tomasz Bold, R. M. Barnett, Tiefu Zhao, Jan-Ulf Mjörnmark, J. Siegrist, J. K. Kraus, H. Matsunaga, S. J. Chen, E. Brambilla, Ulrike Blumenschein, M. P. Schmidt, P. Jussel, K. Grybel, L. Capasso, R. Pravahan, A. C. Falou, Robert Stanek, Tadashi Maeno, T. Göttfert, Stéphane Jézéquel, T. Poghosyan, J. Huston, A. N. Karyukhin, J. Idarraga, Daniel Pomarède, Alexey Dudarev, Philippe Grenier, Wladyslaw Dabrowski, Brad Abbott, E. C. Katsoufis, P. M. Manning, Maarten Boonekamp, Andrej Filipcic, Katarzyna Kordas, Lydia Roos, C. Bromberg, P. F. Giraud, Peter Love, C. Osuna, J. Drees, N. D. Topilin, G. Wooden, N. A. McCubbin, K. Pretzl, A. R. Davison, J. Tobias, M. A. L. Leite, R. J. Madaras, Evangelos Gazis, M. R. Jaekel, Y. Jiang, C. Menot, Yoshio Arai, A. A. Korol, Claude Guyot, Sinead Farrington, Georg Zobernig, Yoji Hasegawa, Clemens Lange, W. Lau, S. Hasegawa, M. Seman, G. Lutz, Marco Barbero, M. Rose, Claudia Ciocca, Ketevi Assamagan, M. Thioye, L. Zanello, T. Ehrich, J. R. Carter, Jieh-Wen Tsung, Alessandro Cerri, Philip Bechtle, A. Glazov, H. M. Braun, Hiroyuki Iwasaki, John-Bjarne Hansen, E. Le Guirriec, F. Vannucci, Clement Helsens, B. Demirkoz, Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Centre de Calcul de l'IN2P3 (CC-IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), APC - Neutrinos, AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Institute of High Energy Physics (IHEP), Chinese Academy of Sciences [Changchun Branch] (CAS), ATLAS, Aad, G, Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Cevenini, Francesco, Chiefari, Giovanni, DELLA VOLPE, Domenico, Merola, Leonardo, Patricelli, Sergio, Conventi, F., DELLA PIETRA, Massimo, Giordano, Raffaele, Musto, E., Rossi, E., Sanchez, A., Carlino, G., de Asmundis, R., Doria, A., Iengo, P., Izzo, V., Sekhniaidze, G., ATLAS (IHEF, IoP, FNWI), Abbott, B, Abdallah, J, Abdelalim, Aa, Abdesselam, A, Abdinov, O, Abi, B, Abolins, M, Abramowicz, H, Abreu, H, Acerbi, E, Acharya, B, Ackers, M, Adams, Dl, Addy, Tn, Adelman, J, Aderholz, M, Adomeit, S, Adragna, P, Adye, T, Aefsky, S, Aguilar Saavedra, Ja, Aharrouche, M, Ahlen, Sp, Ahles, F, Ahmad, A, Ahsan, M, Aielli, G, Akdogan, T, Akesson, Tpa, Akimoto, G, Akimov, Av, Alam, M, Alam, Ma, Albrand, S, Aleksa, M, Aleksandrov, In, Aleppo, M, Alessandria, F, Alexa, C, Alexander, G, Alexandre, G, Alexopoulos, T, Alhroob, M, Aliev, M, Alimonti, G, Alison, J, Aliyev, M, Allport, Pp, Allwood Spiers, Se, Almond, J, Aloisio, A, Alon, R, Alonso, A, Alonso, J, Alviggi, Mg, Amako, K, Amaral, P, Amelung, C, Ammosov, Vv, Amorim, A, Amoros, G, Amram, N, Anastopoulos, C, Andeen, T, Anders, Cf, Anderson, Kj, Andreazza, A, Andrei, V, Andrieux, Ml, Anduaga, X, Angerami, A, Anghinolfi, F, Anjos, N, Annovi, A, Antonaki, A, Antonelli, M, Antonelli, S, Antos, J, Anulli, F, Aoun, S, Bella, La, Apolle, R, Arabidze, G, Aracena, I, Arai, Y, Arce, Ath, Archambault, Jp, Arfaoui, S, Arguin, Jf, Arik, E, Arik, M, Armbruster, Aj, Arms, Ke, Armstrong, Sr, Arnaez, O, Arnault, C, Artamonov, A, Artoni, G, Arutinov, D, Asai, S, Asfandiyarov, R, Ask, S, Asman, B, Asquith, L, Assamagan, K, Astbury, A, Astvatsatourov, A, Atoian, G, Aubert, B, Auerbach, B, Auge, E, Augsten, K, Aurousseau, M, Austin, N, Avramidou, R, Axen, D, Ay, C, Azuelos, G, Azuma, Y, Baak, Ma, Baccaglioni, G, Bacci, C, Bach, Am, Bachacou, H, Bachas, K, Bachy, G, Backes, M, Badescu, E, Bagnaia, P, Bahinipati, S, Bai, Y, Bailey, Dc, Bain, T, Baines, Jt, Baker, Ok, Baker, S, Pedrosa, Fbd, Banas, E, Banerjee, P, Banerjee, S, Banfi, D, Bangert, A, Bansal, V, Bansil, H, Barak, L, Baranov, Sp, Barashkou, A, Galtieri, Ab, Barber, T, Barberio, El, Barberis, D, Barbero, M, Bardin, Dy, Barillari, T, Barisonzi, M, Barklow, T, Barlow, N, Barnett, Bm, Barnett, Rm, Baroncelli, A, Barr, Aj, Barreiro, F, da Costa, Jbg, Barrillon, P, Bartoldus, R, Barton, Ae, Bartsch, D, Bates, Rl, Batkova, L, Batley, Jr, Battaglia, A, Battistin, M, Battistoni, G, Bauer, F, Bawa, H, Beare, B, Beau, T, Beauchemin, Ph, Beccherle, R, Bechtle, P, Beck, Hp, Beckingham, M, Becks, Kh, Beddall, Aj, Beddall, A, Bednyakov, Va, Bee, C, Begel, M, Harpaz, Sb, Behera, Pk, Beimforde, M, Belanger Champagne, C, Bell, Pj, Bell, Wh, Bella, G, Bellagamba, L, Bellina, F, Bellomo, G, Bellomo, M, Belloni, A, Belotskiy, K, Beltramello, O, Ben Ami, S, Benary, O, Benchekroun, D, Benchouk, C, Bendel, M, Benedict, Bh, Benekos, N, Benhammou, Y, Benjamin, Dp, Benoit, M, Bensinger, Jr, Benslama, K, Bentvelsen, S, Berge, D, Kuutmann, Eb, Berger, N, Berghaus, F, Berglund, E, Beringer, J, Bernardet, K, Bernat, P, Bernhard, R, Bernius, C, Berry, T, Bertin, A, Bertinelli, F, Bertolucci, F, Besana, Mi, Besson, N, Bethke, S, Bhimji, W, Bianchi, Rm, Bianco, M, Biebel, O, Biesiada, J, Biglietti, M, Bilokon, H, Bindi, M, Bingul, A, Bini, C, Biscarat, C, Bitenc, U, Black, Km, Blair, Re, Blanchard, Jb, Blanchot, G, Blocker, C, Blocki, J, Blondel, A, Blum, W, Blumenschein, U, Bobbink, Gj, Bobrovnikov, Vb, Bocci, A, Bock, R, Boddy, Cr, Boehler, M, Boek, J, Boelaert, N, Boser, S, Bogaerts, Ja, Bogdanchikov, A, Bogouch, A, Bohm, C, Boisvert, V, Bold, T, Boldea, V, Bona, M, Boonekamp, M, Boorman, G, Booth, Cn, Booth, P, Booth, Jra, Bordoni, S, Borer, C, Borisov, A, Borissov, G, Borjanovic, I, Borroni, S, Bos, K, Boscherini, D, Bosman, M, Boterenbrood, H, Botterill, D, Bouchami, J, Boudreau, J, Bouhova Thacker, Ev, Boulahouache, C, Bourdarios, C, Bousson, N, Boveia, A, Boyd, J, Boyko, Ir, Bozhko, Ni, Bozovic Jelisavcic, I, Bracinik, J, Braem, A, Brambilla, E, Branchini, P, Brandenburg, Gw, Brandt, A, Brandt, G, Brandt, O, Bratzler, U, Brau, B, Brau, Je, Braun, Hm, Brelier, B, Bremer, J, Brenner, R, Bressler, S, Breton, D, Brett, Nd, Bright Thomas, Pg, Britton, D, Brochu, Fm, Brock, I, Brock, R, Brodbeck, Tj, Brodet, E, Broggi, F, Bromberg, C, Brooijmans, G, Brooks, Wk, Brown, G, Brubaker, E, de Renstrom, Pab, Bruncko, D, Bruneliere, R, Brunet, S, Bruni, A, Bruni, G, Bruschi, M, Buanes, T, Bucci, F, Buchanan, J, Buchanan, Nj, Buchholz, P, Buckingham, Rm, Buckley, Ag, Buda, Si, Budagov, Ia, Budick, B, Buscher, V, Bugge, L, Buira Clark, D, Buis, Ej, Bulekov, O, Bunse, M, Buran, T, Burckhart, H, Burdin, S, Burgess, T, Burke, S, Busato, E, Bussey, P, Buszello, Cp, Butin, F, Butler, B, Butler, Jm, Buttar, Cm, Butterworth, Jm, Buttinger, W, Byatt, T, Urban, Sc, Caccia, M, Caforio, D, Cakir, O, Calafiura, P, Calderini, G, Calfayan, P, Calkins, R, Caloba, Lp, Caloi, R, Calvet, D, Calvet, S, Camard, A, Camarri, P, Cambiaghi, M, Cameron, D, Cammin, J, Campana, S, Campanelli, M, Canale, V, Canelli, F, Canepa, A, Cantero, J, Capasso, L, Garrido, Mdmc, Caprini, I, Caprini, M, Capriotti, D, Capua, M, Caputo, R, Caramarcu, C, Cardarelli, R, Carli, T, Carlino, G, Carminati, L, Caron, B, Caron, S, Carpentieri, C, Montoya, Gdc, Montero, Sc, Carter, Aa, Carter, Jr, Carvalho, J, Casadei, D, Casado, Mp, Cascella, M, Caso, C, Hernandez, Amc, Castaneda Miranda, E, Gimenez, Vc, Castro, Nf, Cataldi, G, Cataneo, F, Catinaccio, A, Catmore, Jr, Cattai, A, Cattani, G, Caughron, S, Cavallari, A, Cavalleri, P, Cavalli, D, Cavalli Sforza, M, Cavasinni, V, Cazzato, A, Ceradini, Filippo, Cerna, C, Cerqueira, A, Cerri, A, Cerrito, L, Cerutti, F, Cetin, Sa, Cevenini, F, Chafaq, A, Chakraborty, D, Chan, K, Chapleau, B, Chapman, Jd, Chapman, Jw, Chareyre, E, Charlton, Dg, Chavda, V, Cheatham, S, Chekanov, S, Chekulaev, Sv, Chelkov, Ga, Chen, H, Chen, L, Chen, S, Chen, T, Chen, X, Cheng, S, Cheplakov, A, Chepurnov, Vf, El Moursli, Rc, Chernyatin, V, Cheu, E, Cheung, Sl, Chevalier, L, Chevallier, F, Chiefari, G, Chikovani, L, Childers, Jt, Chilingarov, A, Chiodini, G, Chizhov, Mv, Choudalakis, G, Chouridou, S, Christidi, Ia, Christov, A, Chromek Burckhart, D, Chu, Ml, Chudoba, J, Ciapetti, G, Ciftci, Ak, Ciftci, R, Cinca, D, Cindro, V, Ciobotaru, Md, Ciocca, C, Ciocio, A, Cirilli, M, Ciubancan, M, Clark, A, Clark, Pj, Cleland, W, Clemens, Jc, Clement, B, Clement, C, Clifft, Rw, Coadou, Y, Cobal, M, Coccaro, A, Cochran, J, Coe, P, Cogan, Jg, Coggeshall, J, Cogneras, E, Cojocaru, Cd, Colas, J, Colijn, Ap, Collard, C, Collins, Nj, Collins Tooth, C, Collot, J, Colon, G, Coluccia, R, Comune, G, Muino, Pc, Coniavitis, E, Conidi, Mc, Consonni, M, Constantinescu, S, Conta, C, Conventi, F, Cook, J, Cooke, M, Cooper, Bd, Cooper Sarkar, Am, Cooper Smith, Nj, Copic, K, Cornelissen, T, Corradi, M, Correard, S, Corriveau, F, Cortes Gonzalez, A, Cortiana, G, Costa, G, Costa, Mj, Costanzo, D, Costin, T, Cote, D, Torres, Rc, Courneyea, L, Cowan, G, Cowden, C, Cox, Be, Cranmer, K, Cristinziani, M, Crosetti, G, Crupi, R, Crepe Renaudin, S, Almenar, Cc, Donszelmann, Tc, Cuneo, S, Curatolo, M, Curtis, Cj, Cwetanski, P, Czirr, H, Czyczula, Z, D'Auria, S, D'Onofrio, M, D'Orazio, A, Mello, Adg, Da Silva, Pvm, Da Via, C, Dabrowski, W, Dahlhoff, A, Dai, T, Dallapiccola, C, Dallison, Sj, Dam, M, Dameri, M, Damiani, D, Danielsson, Ho, Dankers, R, Dannheim, D, Dao, V, Darbo, G, Darlea, Gl, Daum, C, Dauvergne, Jp, Davey, W, Davidek, T, Davidson, N, Davidson, R, Davies, M, Davison, Ar, Dawe, E, Dawson, I, Dawson, Jw, Daya, Rk, De, K, de Asmundis, R, De Castro, S, De Cecco, S, de Graat, J, De Groot, N, de Jong, P, De La Cruz Burelo, E, De La Taille, C, De Lotto, B, De Mora, L, De Nooij, L, Branco, Mdo, De Pedis, D, de Saintignon, P, De Salvo, A, De Sanctis, U, De Santo, A, De Regie, Jbdv, Dean, S, Dedes, G, Dedovich, Dv, Degenhardt, J, Dehchar, M, Deile, M, Del Papa, C, Del Peso, J, Del Prete, T, Dell'Acqua, A, Dell'Asta, L, Della Pietra, M, della Volpe, D, Delmastro, M, Delpierre, P, Delruelle, N, Delsart, Pa, Deluca, C, Demers, S, Demichev, M, Demirkoz, B, Deng, J, Denisov, Sp, Dennis, C, Derendarz, D, Derkaoui, Je, Derue, F, Dervan, P, Desch, K, Devetak, E, Deviveiros, Po, Dewhurst, A, Dewilde, B, Dhaliwal, S, Dhullipudi, R, Di Ciaccio, A, Di Ciaccio, L, Di Girolamo, A, Di Girolamo, B, Di Luise, S, Di Mattia, A, Di Nardo, R, Di Simone, A, Di Sipio, R, Diaz, Ma, Diblen, F, Diehl, Eb, Dietl, H, Dietrich, J, Dietzsch, Ta, Diglio, S, Yagci, Kd, Dingfelder, J, Dionisi, C, Dita, P, Dita, S, Dittus, F, Djama, F, Djilkibaev, R, Djobava, T, do Vale, Mab, Wemans, Adv, Doan, Tko, Dobbs, M, Dobinson, R, Dobos, D, Dobson, E, Dobson, M, Dodd, J, Dogan, Ob, Doglioni, C, Doherty, T, Doi, Y, Dolejsi, J, Dolenc, I, Dolezal, Z, Dolgoshein, Ba, Dohmae, T, Donadelli, M, Donega, M, Donini, J, Dopke, J, Doria, A, Dos Anjos, A, Dosil, M, Dotti, A, Dova, Mt, Dowell, Jd, Doxiadis, Ad, Doyle, At, Drasal, Z, Drees, J, Dressnandt, N, Drevermann, H, Driouichi, C, Dris, M, Drohan, Jg, Dubbert, J, Dubbs, T, Dube, S, Duchovni, E, Duckeck, G, Dudarev, A, Dudziak, F, Duhrssen, M, Duerdoth, Ip, Duflot, L, Dufour, Ma, Dunford, M, Yildiz, Hd, Duxfield, R, Dwuznik, M, Dydak, F, Dzahini, D, Duren, M, Ebke, J, Eckert, S, Eckweiler, S, Edmonds, K, Edwards, Ca, Efthymiopoulos, I, Ehrenfeld, W, Ehrich, T, Eifert, T, Eigen, G, Einsweiler, K, Eisenhandler, E, Ekelof, T, El Kacimi, M, Ellert, M, Elles, S, Ellinghaus, F, Ellis, K, Ellis, N, Elmsheuser, J, Elsing, M, Ely, R, Emeliyanov, D, Engelmann, R, Engl, A, Epp, B, Eppig, A, Erdmann, J, Ereditato, A, Eriksson, D, Ernst, J, Ernst, M, Ernwein, J, Errede, D, Errede, S, Ertel, E, Escalier, M, Escobar, C, Curull, Xe, Esposito, B, Etienne, F, Etienvre, Ai, Etzion, E, Evangelakou, D, Evans, H, Fabbri, L, Fabre, C, Facius, K, Fakhrutdinov, Rm, Falciano, S, Falou, Ac, Fang, Y, Fanti, M, Farbin, A, Farilla, A, Farley, J, Farooque, T, Farrington, Sm, Farthouat, P, Fasching, D, Fassnacht, P, Fassouliotis, D, Fatholahzadeh, B, Favareto, A, Fayard, L, Fazio, S, Febbraro, R, Federic, P, Fedin, Ol, Fedorko, I, Fedorko, W, Fehling Kaschek, M, Feligioni, L, Fellmann, D, Felzmann, Cu, Feng, C, Feng, Ej, Fenyuk, Ab, Ferencei, J, Ferguson, D, Ferland, J, Fernandes, B, Fernando, W, Ferrag, S, Ferrando, J, Ferrara, V, Ferrari, A, Ferrari, P, Ferrari, R, Ferrer, A, Ferrer, Ml, Ferrere, D, Ferretti, C, Parodi, Af, Fiascaris, M, Fiedler, F, Filipcic, A, Filippas, A, Filthaut, F, Fincke Keeler, M, Fiolhais, Mcn, Fiorini, L, Firan, A, Fischer, G, Fischer, P, Fisher, Mj, Fisher, Sm, Flammer, J, Flechl, M, Fleck, I, Fleckner, J, Fleischmann, P, Fleischmann, S, Flick, T, Castillo, Lrf, Flowerdew, Mj, Fohlisch, F, Fokitis, M, Martin, Tf, Forbush, Da, Formica, A, Forti, A, Fortin, D, Foster, Jm, Fournier, D, Foussat, A, Fowler, Aj, Fowler, K, Fox, H, Francavilla, P, Franchino, S, Francis, D, Frank, T, Franklin, M, Franz, S, Fraternali, M, Fratina, S, French, St, Froeschl, R, Froidevaux, D, Frost, Ja, Fukunaga, C, Torregrosa, Ef, Fuster, J, Gabaldon, C, Gabizon, O, Gadfort, T, Gadomski, S, Gagliardi, G, Gagnon, P, Galea, C, Gallas, Ej, Gallas, Mv, Gallo, V, Gallop, Bj, Gallus, P, Galyaev, E, Gan, Kk, Gao, Y, Gapienko, Va, Gaponenko, A, Garberson, F, Garcia Sciveres, M, Garcia, C, Navarro, Jeg, Gardner, Rw, Garelli, N, Garitaonandia, H, Garonne, V, Garvey, J, Gatti, C, Gaudio, G, Gaumer, O, Gaur, B, Gauthier, L, Gavrilenko, Il, Gay, C, Gaycken, G, Gayde, Jc, Gazis, En, Ge, P, Gee, Cnp, Geich Gimbel, C, Gellerstedt, K, Gemme, C, Gemmell, A, Genest, Mh, Gentile, S, Georgatos, F, George, S, Gerlach, P, Gershon, A, Geweniger, C, Ghazlane, H, Ghez, P, Ghodbane, N, Giacobbe, B, Giagu, S, Giakoumopoulou, V, Giangiobbe, V, Gianotti, F, Gibbard, B, Gibson, A, Gibson, Sm, Gieraltowski, Gf, Gilbert, Lm, Gilchriese, M, Gildemeister, O, Gilewsky, V, Gillberg, D, Gillman, Ar, Gingrich, Dm, Ginzburg, J, Giokaris, N, Giordano, R, Giorgi, Fm, Giovannini, P, Giraud, Pf, Giugni, D, Giusti, P, Gjelsten, Bk, Gladilin, Lk, Glasman, C, Glatzer, J, Glazov, A, Glitza, Kw, Glonti, Gl, Godfrey, J, Godlewski, J, Goebel, M, Gopfert, T, Goeringer, C, Gossling, C, Gottfert, T, Goldfarb, S, Goldin, D, Golling, T, Gollub, Np, Golovnia, Sn, Gomes, A, Fajardo, Lsg, Goncalo, R, Gonella, L, Gong, C, Gonidec, A, Gonzalez, S, de la Hoz, Sg, Silva, Mlg, Gonzalez Sevilla, S, Goodson, Jj, Goossens, L, Gorbounov, Pa, Gordon, Ha, Gorelov, I, Gorfine, G, Gorini, B, Gorini, E, Gorisek, A, Gornicki, E, Gorokhov, Sa, Gorski, Bt, Goryachev, Vn, Gosdzik, B, Gosselink, M, Gostkin, Mi, Gouanere, M, Eschrich, Ig, Gouighri, M, Goujdami, D, Goulette, Mp, Goussiou, Ag, Goy, C, Grabowska Bold, I, Grabski, 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Vorobel, A. P. Vorobiev, V. Vorwerk, M. Vos, R. Voss, T. T. Voss, J. H. Vossebeld, A. S. Vovenko, N. Vranjes, M. Vranjes Milosavljevic, V. Vrba, M. Vreeswijk, T. Vu Anh, R. Vuillermet, I. Vukotic, W. Wagner, P. Wagner, H. Wahlen, J. Wakabayashi, J. Walbersloh, S. Walch, J. Walder, R. Walker, W. Walkowiak, R. Wall, P. Waller, C. Wang, H. Wang, J. Wang, J. C. Wang, R. Wang, S. M. Wang, A. Warburton, C. P. Ward, M. Warsinsky, P. M. Watkins, A. T. Watson, M. F. Watson, G. Watts, S. Watts, A. T. Waugh, B. M. Waugh, J. Weber, M. Weber, M. S. Weber, P. Weber, A. R. Weidberg, J. Weingarten, C. Weiser, H. Wellenstein, P. S. Wells, M. Wen, T. Wenaus, S. Wendler, Z. Weng, T. Wengler, S. Wenig, N. Wermes, M. Werner, P. Werner, M. Werth, M. Wessels, K. Whalen, S. J. Wheeler-Ellis, S. P. Whitaker, A. White, M. J. White, S. White, S. R. Whitehead, D. Whiteson, D. Whittington, F. Wicek, D. Wicke, F. J. Wickens, W. Wiedenmann, M. Wielers, P. Wienemann, C. Wiglesworth, L. A. M. Wiik, A. Wildauer, M. A. Wildt, I. Wilhelm, H. G. Wilkens, J. Z. Will, E. Williams, H. H. Williams, W. Willis, S. Willocq, J. A. Wilson, M. G. Wilson, A. Wilson, I. Wingerter-Seez, S. Winkelmann, F. Winklmeier, M. Wittgen, M. W. Wolter, H. Wolters, G. Wooden, B. K. Wosiek, J. Wotschack, M. J. Woudstra, K. Wraight, C. Wright, B. Wrona, S. L. Wu, X. Wu, Y. Wu, E. Wulf, R. Wunstorf, B. M. Wynne, L. Xaplanteris, S. Xella, S. Xie, Y. Xie, C. Xu, D. Xu, G. Xu, B. Yabsley, M. Yamada, A. Yamamoto, K. Yamamoto, S. Yamamoto, T. Yamamura, J. Yamaoka, T. Yamazaki, Y. Yamazaki, Z. Yan, H. Yang, U. K. Yang, Y. Yang, Y. Yang, Z. Yang, S. Yanush, W-M. Yao, Y. Yao, Y. Yasu, J. Ye, S. Ye, M. Yilmaz, R. Yoosoofmiya, K. Yorita, R. Yoshida, C. Young, S. Youssef, D. Yu, J. Yu, J. Yu, L. Yuan, A. Yurkewicz, V. G. Zaets, R. Zaidan, A. M. Zaitsev, Z. Zajacova, Yo.K. Zalite, L. Zanello, P. Zarzhitsky, A. Zaytsev, M. Zdrazil, C. Zeitnitz, M. Zeller, P. F. Zema, A. Zemla, C. Zendler, A. V. Zenin, O. Zenin, T. Ženiš, Z. Zenonos, S. Zenz, D. Zerwas, G. Zevi della Porta, Z. Zhan, D. Zhang, H. Zhang, J. Zhang, X. Zhang, Z. Zhang, L. Zhao, T. Zhao, Z. Zhao, A. Zhemchugov, S. Zheng, J. Zhong, B. Zhou, N. Zhou, Y. Zhou, C. G. Zhu, H. Zhu, Y. Zhu, X. Zhuang, V. Zhuravlov, D. Zieminska, B. Zilka, R. Zimmermann, S. Zimmermann, S. Zimmermann, M. Ziolkowski, R. Zitoun, L. Živković, V. V. Zmouchko, G. Zobernig, A. Zoccoli, Y. Zolnierowski, A. Zsenei, M. zur Nedden, V. Zutshi, L. Zwalinski, Doğuş Üniversitesi, Fen Edebiyat Fakültesi, Fizik Bölümü, TR3959, Çetin, Serkant Ali, G., Aad, Bianco, Michele, G., Chiodini, M. R., Coluccia, Gorini, Edoardo, Primavera, Margherita, Spagnolo, Stefania Antonia, Ventura, Andrea, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), UAM. Departamento de Física Teórica, Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC)-AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Universidade do Minho, Abdelalim Aly, Ahmed Aly, Alexandre, Gauthier, Backes, Moritz, Bell, Paul, Bell, William, Berglund, Frida Elina, Blondel, Alain, Bucci, Francesca, Clark, Allan Geoffrey, Dao, Valerio, Efthymiopoulos, Ilias, Ferrere, Didier, Gadomski, Szymon, Garcia Navarro, Jose Enrique, Gaumer, Olivier, Gonzalez Sevilla, Sergio, Goulette, Marc, Hamilton, Andrew, Leger, Annie, Lister, Alison, Macina-Buono, Daniela, Martin Dit Latour, Bertrand, Mikulec, Bettina, Moneta, Lorenzo, Mora Herrera, Maria Clemencia Rosario, Morone, Maria Cristina, Nektarijevic, Snezana, Orellana, Frédérik, Pasztor, Arpad, Pohl, Martin, Robichaud-Veronneau, Andrée, Rosselet, Laurent, Urquijo, Phillip, Wu, Xin, and ATLAS Collaboration (ukupan broj autora: 3048)
- Subjects
Particle physics ,MISSING TRANSVERSE ENERGY ,Ciências Naturais::Ciências Físicas ,Atlas detector ,Ciências Físicas [Ciências Naturais] ,FIS/04 - Fisica Nucleare e Subnucleare ,General Physics and Astronomy ,FOS: Physical sciences ,transverse energy: missing-energy ,ATLAS ,universal extra dimension ,compactification ,CERN LHC Coll ,background ,p p: interaction ,final state: two-photon ,photon: Kaluza-Klein ,electroweak interaction: standard model: validity test ,experimental results ,7000 GeV-cms ,ddc:500.2 ,01 natural sciences ,7. Clean energy ,High Energy Physics - Experiment ,Nuclear physics ,Universal extra dimension ,High Energy Physics - Experiment (hep-ex) ,0103 physical sciences ,ddc:550 ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,diphoton ,events ,transverse energy ,proton-proton collisions ,Hadron ,ddc:530 ,High Energy Physics ,Specific model ,010306 general physics ,Nuclear Experiment ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,QC ,Physics ,Large Hadron Collider ,Science & Technology ,Compactification (physics) ,010308 nuclear & particles physics ,Atlas (topology) ,Settore FIS/01 - Fisica Sperimentale ,Física ,FIS/01 - Fisica Sperimentale ,Transverse plane ,Col·lisions (Física nuclear) ,Experimental High Energy Physics ,Universal Extra Dimensions ,Física nuclear ,High Energy Physics::Experiment ,LHC ,Particle Physics - Experiment - Abstract
A search for diphoton events with large missing transverse energy is presented. The data were collected with the ATLAS detector in proton-proton collisions at √s=7 TeV at the CERN Large Hadron Collider and correspond to an integrated luminosity of 3.1 pb−1. No excess of such events is observed above the standard model background prediction. In the context of a specific model with one universal extra dimension with compactification radius R and gravity-induced decays, values of 1/R, We wish to thank CERN for the efficient commissioning and operation of the LHC during this initial high-energy data-taking period as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; ARTEMIS, European Union; IN2P3-CNRS, CEA-DSM/IRFU, France; GNAS, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; GSRT, Greece; ISF, MINERVA, GIF, DIP and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; RCN, Norway; MNiSW, Poland; GRICES and FCT, Portugal; MERYS (MECTS), Romania; MES of Russia and ROSATOM, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MVZT, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of America. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular, from CERN and the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA) and in the Tier-2 facilities worldwide., info:eu-repo/semantics/publishedVersion
- Published
- 2011
25. Measurement of the inclusive isolated prompt photon cross section in pp collisions at √s=7 TeV with the ATLAS detector
- Author
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Aad, G., Abbott, B., Abdallah, J., Abdelalim, A. A., Abdesselam, A., Abdinov, O., Abi, B., Abolins, M., Abramowicz, H., Abreu, H., Acerbi, E., Acharya, B. S., Ackers, M., Adams, D. L., Addy, T. N., Adelman, J., Aderholz, M., Adomeit, S., Adragna, P., Adye, T., Aefsky, S., Aguilar-Saavedra, J. A., Aharrouche, M., Ahlen, S. P., Ahles, F., Ahmad, A., Ahsan, M., Aielli, G., Akdogan, T., Åkesson, T. P. A., Akimoto, G., Akimov, A. V., Alam, M. S., Alam, M. A., Albrand, S., Aleksa, M., Aleksandrov, I. N., Aleppo, M., Alessandria, F., Alexa, C., Alexander, G., Alexandre, G., Alexopoulos, T., Alhroob, M., Aliev, M., Alimonti, G., Alison, J., Aliyev, M., Allport, P. P., Allwood-Spiers, S. E., Almond, J., Aloisio, A., Alon, R., Alonso, A., Alonso, J., Alviggi, M. G., Amako, K., Amaral, P., Amelung, C., Ammosov, V. V., Amorim, A., Amorós, G., Amram, N., Anastopoulos, C., Andari, N., Andeen, T., Anders, C. F., Anderson, K. J., Andreazza, A., Andrei, V., Andrieux, M. -L., Anduaga, X. S., Angerami, A., Anghinolfi, F., Anjos, N., Annovi, A., Antonaki, A., Antonelli, M., Antonelli, S., Antos, J., Anulli, F., Aoun, S., Aperio Bella, L., Apolle, R., Arabidze, G., Aracena, I., Arai, Y., Arce, A. T. H., Archambault, J. P., Arfaoui, S., Arguin, J. -F., Arik, E., Arik, M., Armbruster, A. J., Arms, K. E., Armstrong, S. R., Arnaez, O., Arnault, C., Artamonov, A., Artoni, G., Arutinov, D., Asai, S., Asfandiyarov, R., Ask, S., Åsman, B., Asquith, L., Assamagan, K., Astbury, A., Astvatsatourov, A., Atoian, G., Aubert, B., Auerbach, B., Auge, E., Augsten, K., Aurousseau, M., Austin, N., Avramidou, R., Axen, D., Ay, C., Azuelos, G., Azuma, Y., Baak, M. A., Baccaglioni, G., Bacci, C., Bach, A. M., Bachacou, H., Bachas, K., Bachy, G., Backes, M., Badescu, E., Bagnaia, P., Bahinipati, S., Bai, Y., Bailey, D. C., Bain, T., Baines, J. T., Baker, O. K., Baker, S., Baltasar Dos Santos Pedrosa, F., Banas, E., Banerjee, P., Banerjee, Sw., Banfi, D., Bangert, A., Bansal, V., Bansil, H. S., Barak, L., Baranov, S. P., Barashkou, A., Barbaro Galtieri, A., Barber, T., Barberio, E. L., Barberis, D., Barbero, M., Bardin, D. Y., Barillari, T., Barisonzi, M., Barklow, T., Barlow, N., Barnett, B. M., Barnett, R. M., Baroncelli, A., Barr, A. J., Barreiro, F., Barreiro Guimarães Da Costa, J., Barrillon, P., Bartoldus, R., Barton, A. E., Bartsch, D., Bates, R. L., Batkova, L., Batley, J. R., Battaglia, A., Battistin, M., Battistoni, G., Bauer, F., Bawa, H. S., Beare, B., Beau, T., Beauchemin, P. H., Beccherle, R., Bechtle, P., Beck, H. P., Beckingham, M., Becks, K. H., Beddall, A. J., Beddall, A., Bednyakov, V. A., Bee, C., Begel, M., Behar Harpaz, S., Behera, P. K., Beimforde, M., Belanger-Champagne, C., Belhorma, B., Bell, P. J., Bell, W. H., Bella, G., Bellagamba, L., Bellina, F., Bellomo, G., Bellomo, M., Belloni, A., Belotskiy, K., Beltramello, O., Ben Ami, S., Benary, O., Benchekroun, D., Benchouk, C., Bendel, M., Benedict, B. H., Benekos, N., Benhammou, Y., Benjamin, D. P., Benoit, M., Bensinger, J. R., Benslama, K., Bentvelsen, S., Berge, D., Bergeaas Kuutmann, E., Berger, N., Berghaus, F., Berglund, E., Beringer, J., Bernardet, K., Bernat, P., Bernhard, R., Bernius, C., Berry, T., Bertin, A., Bertinelli, F., Bertolucci, F., Besana, M. I., Besson, N., Bethke, S., Bhimji, W., Bianchi, R. M., Bianco, M., Biebel, O., Biesiada, J., Biglietti, M., Bilokon, H., Bindi, M., Bingul, A., Bini, C., Biscarat, C., Bischof, R., Bitenc, U., Black, K. M., Blair, R. E., Blanchard, J. -B., Blanchot, G., Blocker, C., Blocki, J., Blondel, A., Blum, W., Blumenschein, U., Boaretto, C., Bobbink, G. J., Bobrovnikov, V. B., Bocci, A., Bock, R., Boddy, C. R., Boehler, M., Boek, J., Boelaert, N., Böser, S., Bogaerts, J. A., Bogdanchikov, A., Bogouch, A., Bohm, C., Boisvert, V., Bold, T., Boldea, V., Bona, M., Boonekamp, M., Boorman, G., Booth, C. N., Booth, P., Booth, J. R. A., Bordoni, S., Borer, C., Borisov, A., Borissov, G., Borjanovic, I., Borroni, S., Bos, K., Boscherini, D., Bosman, M., Boterenbrood, H., Botterill, D., Bouchami, J., Boudreau, J., Bouhova-Thacker, E. V., Boulahouache, C., Bourdarios, C., Bousson, N., Boveia, A., Boyd, J., Boyko, I. R., Bozhko, N. I., Bozovic-Jelisavcic, I., Braccini, S., Bracinik, J., Braem, A., Brambilla, E., Branchini, P., Brandenburg, G. W., Brandt, A., Brandt, G., Brandt, O., Bratzler, U., Brau, B., Brau, J. E., Braun, H. M., Brelier, B., Bremer, J., Brenner, R., Bressler, S., Breton, D., Brett, N. D., Bright-Thomas, P. G., Britton, D., Brochu, F. M., Brock, I., Brock, R., Brodbeck, T. J., Brodet, E., Broggi, F., Bromberg, C., Brooijmans, G., Brooks, W. K., Brown, G., Brubaker, E., Bruckman De Renstrom, P. A., Bruncko, D., Bruneliere, R., Brunet, S., Bruni, A., Bruni, G., Bruschi, M., Buanes, T., Bucci, F., Buchanan, J., Buchanan, N. J., Buchholz, P., Buckingham, R. M., Buckley, A. G., Buda, S. I., Budagov, I. 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I. Pedraza Morales, S. J. M. Peeters, S. V. Peleganchuk, H. Peng, R. Pengo, A. Penson, J. Penwell, M. Perantoni, K. Perez, T. Perez Cavalcanti, E. Perez Codina, M. T. Pérez García-Estañ, V. Perez Reale, I. Peric, L. Perini, H. Pernegger, R. Perrino, P. Perrodo, S. Persembe, P. Perus, V. D. Peshekhonov, E. Petereit, O. Peters, B. A. Petersen, J. Petersen, T. C. Petersen, E. Petit, A. Petridis, C. Petridou, E. Petrolo, F. Petrucci, D. Petschull, M. Petteni, R. Pezoa, A. Phan, A. W. Phillips, P. W. Phillips, G. Piacquadio, E. Piccaro, M. Piccinini, A. Pickford, R. Piegaia, J. E. Pilcher, A. D. Pilkington, J. Pina, M. Pinamonti, A. Pinder, J. L. Pinfold, J. Ping, B. Pinto, O. Pirotte, C. Pizio, R. Placakyte, M. Plamondon, W. G. Plano, M.-A. Pleier, A. V. Pleskach, A. Poblaguev, S. Poddar, F. Podlyski, L. Poggioli, T. Poghosyan, M. Pohl, F. Polci, G. Polesello, A. Policicchio, A. Polini, J. Poll, V. Polychronakos, D. M. Pomarede, D. Pomeroy, K. Pommès, L. Pontecorvo, B. G. Pope, G. A. 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Schegelsky, D. Scheirich, M. I. Scherzer, C. Schiavi, J. Schieck, M. Schioppa, S. Schlenker, J. L. Schlereth, E. Schmidt, M. P. Schmidt, K. Schmieden, C. Schmitt, M. Schmitz, A. Schöning, M. Schott, D. Schouten, J. Schovancova, M. Schram, A. Schreiner, C. Schroeder, N. Schroer, S. Schuh, G. Schuler, J. Schultes, H.-C. Schultz-Coulon, H. Schulz, J. W. Schumacher, M. Schumacher, B. A. Schumm, Ph. Schune, C. Schwanenberger, A. Schwartzman, D. Schweiger, Ph. Schwemling, R. Schwienhorst, R. Schwierz, J. Schwindling, W. G. Scott, J. Searcy, E. Sedykh, E. Segura, S. C. Seidel, A. Seiden, F. Seifert, J. M. Seixas, G. Sekhniaidze, D. M. Seliverstov, B. Sellden, G. Sellers, M. Seman, N. Semprini-Cesari, C. Serfon, L. Serin, R. Seuster, H. Severini, M. E. Sevior, A. Sfyrla, E. Shabalina, M. Shamim, L. Y. Shan, J. T. Shank, Q. T. Shao, M. Shapiro, P. B. Shatalov, L. Shaver, C. Shaw, K. Shaw, D. Sherman, P. Sherwood, A. Shibata, S. Shimizu, M. Shimojima, T. Shin, A. Shmeleva, M. J. Shochet, D. Short, M. A. Shupe, P. Sicho, A. Sidoti, A. Siebel, F. Siegert, J. Siegrist, Dj. Sijacki, O. Silbert, J. Silva, Y. Silver, D. Silverstein, S. B. Silverstein, V. Simak, Lj. Simic, S. Simion, B. Simmons, M. Simonyan, P. Sinervo, N. B. Sinev, V. Sipica, G. Siragusa, A. N. Sisakyan, S. Yu. Sivoklokov, J. Sjölin, T. B. Sjursen, L. A. Skinnari, K. Skovpen, P. Skubic, N. Skvorodnev, M. Slater, T. Slavicek, K. Sliwa, T. J. Sloan, J. Sloper, V. Smakhtin, S. Yu. Smirnov, L. N. Smirnova, O. Smirnova, B. C. Smith, D. Smith, K. M. Smith, M. Smizanska, K. Smolek, A. A. Snesarev, S. W. Snow, J. Snow, J. Snuverink, S. Snyder, M. Soares, R. Sobie, J. Sodomka, A. Soffer, C. A. Solans, M. Solar, J. Solc, U. Soldevila, E. Solfaroli Camillocci, A. A. Solodkov, O. V. Solovyanov, J. Sondericker, N. Soni, V. Sopko, B. Sopko, M. Sorbi, M. Sosebee, A. Soukharev, S. Spagnolo, F. Spanò, R. Spighi, G. Spigo, F. Spila, E. Spiriti, R. Spiwoks, M. Spousta, T. Spreitzer, B. Spurlock, R. D. St. Denis, T. Stahl, J. Stahlman, R. Stamen, E. Stanecka, R. W. Stanek, C. Stanescu, S. Stapnes, E. A. Starchenko, J. Stark, P. Staroba, P. Starovoitov, A. Staude, P. Stavina, G. Stavropoulos, G. Steele, E. Stefanidis, P. Steinbach, P. Steinberg, I. Stekl, B. Stelzer, H. J. Stelzer, O. Stelzer-Chilton, H. Stenzel, K. Stevenson, G. A. Stewart, T. Stockmanns, M. C. Stockton, M. Stodulski, K. Stoerig, G. Stoicea, S. Stonjek, P. Strachota, A. R. Stradling, A. Straessner, J. Strandberg, S. Strandberg, A. Strandlie, M. Strang, E. Strauss, M. Strauss, P. Strizenec, R. Ströhmer, D. M. Strom, J. A. Strong, R. Stroynowski, J. Strube, B. Stugu, I. Stumer, J. Stupak, P. Sturm, D. A. Soh, D. Su, S. Subramania, Y. Sugaya, T. Sugimoto, C. Suhr, K. Suita, M. Suk, V. V. Sulin, S. Sultansoy, T. Sumida, X. Sun, J. E. Sundermann, K. Suruliz, S. Sushkov, G. Susinno, M. R. Sutton, Y. Suzuki, Yu. M. Sviridov, S. Swedish, I. Sykora, T. Sykora, B. Szeless, J. Sánchez, D. Ta, K. Tackmann, A. Taffard, R. Tafirout, A. Taga, N. 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Vahsen, C. Valderanis, J. Valenta, P. Valente, S. Valentinetti, S. Valkar, E. Valladolid Gallego, S. Vallecorsa, J. A. Valls Ferrer, H. van der Graaf, E. van der Kraaij, E. van der Poel, D. van der Ster, B. Van Eijk, N. van Eldik, P. van Gemmeren, Z. van Kesteren, I. van Vulpen, W. Vandelli, G. Vandoni, A. Vaniachine, P. Vankov, F. Vannucci, F. Varela Rodriguez, R. Vari, E. W. Varnes, D. Varouchas, A. Vartapetian, K. E. Varvell, V. I. Vassilakopoulos, F. Vazeille, G. Vegni, J. J. Veillet, C. Vellidis, F. Veloso, R. Veness, S. Veneziano, A. Ventura, D. Ventura, S. Ventura, M. Venturi, N. Venturi, V. Vercesi, M. Verducci, W. Verkerke, J. C. Vermeulen, L. Vertogardov, A. Vest, M. C. Vetterli, I. Vichou, T. Vickey, G. H. A. Viehhauser, S. Viel, M. Villa, M. Villaplana Perez, E. Vilucchi, M. G. Vincter, E. Vinek, V. B. Vinogradov, M. Virchaux, S. Viret, J. Virzi, A. Vitale, O. Vitells, I. Vivarelli, F. Vives Vaque, S. Vlachos, M. Vlasak, N. Vlasov, A. Vogel, P. Vokac, M. Volpi, G. 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- Subjects
Nuclear and High Energy Physics ,Physics and Astronomy (miscellaneous) ,High Energy Physics::Experiment ,+10+GeV%29%3A+Inclusive+production+with+identified+leptons+photons+or+other+nonhadronic+particles%22">Hadron-induced high- and super-high-energy interactions (energy > 10 GeV): Inclusive production with identified leptons photons or other nonhadronic particles - Abstract
A measurement of the cross section for the inclusive production of isolated prompt photons in pp collisions at a center-of-mass energy √s=7 TeV is presented. The measurement covers the pseudorapidity ranges |ηγ
- Published
- 2011
26. Il compito della filosofia nella 'Filosofia della Rivelazione' di Schelling
- Author
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Grazia Tagliavia, BUCHHEIM T., STANCAMPIANO S., SABETTA A., WEDLER W., TOMATIS F., DIETZSCH S., VIEILLARD-BARON J.L., GIOIA G., DANZ C., SCHEIER C.A., FRANZ M., BARBARIC D., DUSING K., JACOBS W.G., GODDARD J.C., SEUBERT H., TAGLIAVIA G., BUBNER R., FRIGO G.F., EHRHARDT W.E., DUSING E., PROCESI L., RIEDEL M., SEGA R., DISSE J., GENSABELLA M., ADOLPHI R., SZIBORSKY L., and TAGLIAVIA G
- Published
- 2006
27. Radiotherapy for Recurrent Medulloblastoma in Children and Adolescents: Survival after Re-Irradiation and First-Time Irradiation.
- Author
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Adolph JE, Fleischhack G, Tschirner S, Rink L, Dittes C, Mikasch R, Dammann P, Mynarek M, Obrecht-Sturm D, Rutkowski S, Bison B, Warmuth-Metz M, Pietsch T, Pfister SM, Pajtler KW, Milde T, Kortmann RD, Dietzsch S, Timmermann B, and Tippelt S
- Abstract
Background: Radiotherapy (RT) involving craniospinal irradiation (CSI) is important in the initial treatment of medulloblastoma. At recurrence, the re-irradiation options are limited and associated with severe side-effects., Methods: For pre-irradiated patients, patients with re-irradiation (RT2) were matched by sex, histology, time to recurrence, disease status and treatment at recurrence to patients without RT2., Results: A total of 42 pre-irradiated patients with RT2 were matched to 42 pre-irradiated controls without RT2. RT2 improved the median PFS [21.0 (CI: 15.7-28.7) vs. 12.0 (CI: 8.1-21.0) months] and OS [31.5 (CI: 27.6-64.8) vs. 20.0 (CI: 14.0-36.7) months]. Concerning long-term survival after ten years, RT2 only lead to small improvements in OS [8% (CI: 1.4-45.3) vs. 0%]. RT2 improved survival most without (re)-resection [PFS: 17.5 (CI: 9.7-41.5) vs. 8.0 (CI: 6.6-12.2)/OS: 31.5 (CI: 27.6-NA) vs. 13.3 (CI: 8.1-20.1) months]. In the RT-naïve patients, CSI at recurrence improved their median PFS [25.0 (CI: 16.8-60.6) vs. 6.6 (CI: 1.5-NA) months] and OS [40.2 (CI: 18.7-NA) vs. 12.4 (CI: 4.4-NA) months]., Conclusions: RT2 could improve the median survival in a matched cohort but offered little benefit regarding long-term survival. In RT-naïve patients, CSI greatly improved their median and long-term survival.
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- 2024
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28. Overcoming inter-observer planning variability in target volume contouring and dose planning for high-risk neuroblastoma - a European multicenter effort of the SIOPEN radiotherapy committee.
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Jazmati D, Brualla L, Littooij AS, Webber B, Dieckmann K, Janssens GO, Simon T, Gaze MN, Merta J, Serrano A, Dietzsch S, Kramer PH, Wulff J, Boterberg T, and Timmermann B
- Subjects
- Humans, Radiotherapy Planning, Computer-Assisted methods, Prospective Studies, Lung, Observer Variation, Radiation Oncology, Neuroblastoma diagnostic imaging, Neuroblastoma radiotherapy
- Abstract
Background and Purpose: To establish an international quality standard for contouring and planning for high-risk neuroblastoma within the prospective High-Risk Neuroblastoma Study 2 of SIOP-Europe-Neuroblastoma (SIOPEN HR-NBL2), which includes a randomized question on dose escalation for residual disease., Materials and Methods: Data on four patients with high-risk neuroblastoma were selected and distributed to the radiotherapy committee of the HR-NBL2 study for independent contouring and planning. Differences in contouring were analyzed using apparent and kappa-corrected agreement. Plans were analyzed regarding the dose-volume histogram metrics. Results were discussed among experts and agreement was obtained., Results: Substantial agreement was found for contouring of the heart (0.64), liver (0.70), left lung (0.74), and right lung (0.74). For contouring of the gastrointestinal tract (0.54), left kidney (0.60), and right kidney (0.59) moderate agreement was obtained. For target volume delineation, agreement for preoperative tumour extent was moderate (0.42), for CTV fair (0.35) and only low (0.06) for residual tumour, respectively. The dose planning strategies appeared to be relatively homogeneous among all experts., Conclusion: Considerable variability was found for the delineation of target volumes, particularly the boost volume, whereas the contouring of the organs at risk and the planning strategy were reasonably consistent. In order to obtain reliable results from the randomized HR-NBL2 trial, standardization of target volume delineation based on adequate imaging is crucial., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier B.V.)
- Published
- 2023
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29. Pseudoprogression Is Frequent After Front-Line Radiation Therapy in Pediatric Low-Grade Glioma: Results From the German Low-Grade Glioma Cohort.
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Stock A, Hancken CV, Kandels D, Kortmann RD, Dietzsch S, Timmermann B, Pietsch T, Bison B, Schmidt R, Pham M, Gnekow AK, and Warmuth-Metz M
- Subjects
- Child, Disease Progression, Female, Humans, Magnetic Resonance Imaging, Male, Brain Neoplasms diagnostic imaging, Brain Neoplasms drug therapy, Brain Neoplasms radiotherapy, Glioma diagnostic imaging, Glioma pathology, Glioma radiotherapy, Proton Therapy
- Abstract
Purpose: Expansion of magnetic resonance imaging T2- or T1-tumor lesion volume after radiation therapy (RT) may indicate pseudoprogression (PsPD). The differentiation between true progression and PsPD is a clinical challenge and underinvestigated in pediatric low-grade glioma (LGG). We evaluated radiologic criteria for PsPD after front-line RT and investigated the frequency and duration of PsPD after 3 RT-modalities within the framework of the German pediatric multicenter LGG-studies., Methods and Materials: Baseline and follow-up magnetic resonance imaging scans of 136 patients (72 male [52.9%], median age at start of RT of 11.3 years [range, 0.8-25.9]) of the Society for Pediatric Oncology-LGG 2004 study and LGG-registry cohorts (
125 iodine-interstitial [IS] RT [n = 51], photon-beam [XRT; n = 60], or proton-beam RT [PBT; n = 25]) were centrally evaluated for increasing: (1) total tumor-associated T2 lesion, (2) focal tumor-associated T2 lesion, and (3) contrast-enhancing tumor during a period of 24 months after RT. The pattern of these criteria initiated "suspicion" of PsPD; their evolution determined "definite" PsPD., Results: Definite PsPD was radiologically determined in 54 of 136 (39.7%) without differences in frequency between RT-modalities: IS 22 of 48 versus XRT 24 of 54 versus PBT 11 of 20; P = .780. Definite PsPD occurred at median 6.3 months (IS 7.2 months; XRT 4.4 months; PBT 6.5 months) after RT-initiation and persisted for median 7.2 months (IS 8.5 months; XRT 7 months; PBT 7.4 months). Appearance of necrosis within the focal tumor-associated T2 lesion proved to be a relevant associated predictor of definite PsPD (P < .001)., Conclusions: PsPD is frequent after irradiation of pediatric LGG and independent of the RT modality (IS vs XRT vs PBT). Adequate identification of PsPD versus true progression is imperative to prevent unneeded salvage treatment., (Copyright © 2021 Elsevier Inc. All rights reserved.)- Published
- 2022
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30. Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma-an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial.
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Dietzsch S, Braesigk A, Seidel C, Remmele J, Kitzing R, Schlender T, Mynarek M, Geismar D, Jablonska K, Schwarz R, Pazos M, Weber DC, Frick S, Gurtner K, Matuschek C, Harrabi SB, Glück A, Lewitzki V, Dieckmann K, Benesch M, Gerber NU, Obrecht D, Rutkowski S, Timmermann B, and Kortmann RD
- Subjects
- Germany, Humans, Quality Control, Radiotherapy Planning, Computer-Assisted, Cerebellar Neoplasms radiotherapy, Medulloblastoma radiotherapy, Radiation Oncology
- Abstract
Purpose: In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but was recommended for patients enrolled in the SIOP PNET5 MB trial between 2014 and 2018. This individual case review (ICR) analysis aimed to evaluate types of deviations in the initial plan proposals and develop uniform review criteria for TB boost., Patients and Methods: A total of 78 patients were registered in this trial, of whom a subgroup of 65 patients were available for evaluation of the TB treatment plans. Dose uniformity was evaluated according to the definitions of the protocol. Additional RT-QC criteria for standardized review of target contours were elaborated and data evaluated accordingly., Results: Of 65 initial TB plan proposals, 27 (41.5%) revealed deviations of target volume delineation. Deviations according to the dose uniformity criteria were present in 14 (21.5%) TB plans. In 25 (38.5%) cases a modification of the RT plan was recommended. Rejection of the TB plans was rather related to unacceptable target volume delineation than to insufficient dose uniformity., Conclusion: In this analysis of pretreatment RT-QC, protocol deviations were present in a high proportion of initial TB plan proposals. These findings emphasize the importance of pretreatment RT-QC in clinical trials for MB. Based on these data, a proposal for RT-QC criteria for tumor bed boost in non-metastatic MB was developed., (© 2021. The Author(s).)
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- 2022
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31. Local and Systemic Therapy of Recurrent Medulloblastomas in Children and Adolescents: Results of the P-HIT-REZ 2005 Study.
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Gaab C, Adolph JE, Tippelt S, Mikasch R, Obrecht D, Mynarek M, Rutkowski S, Pfister SM, Milde T, Witt O, Bison B, Warmuth-Metz M, Kortmann RD, Dietzsch S, Pietsch T, Timmermann B, Sträter R, Bode U, Faldum A, Kwiecien R, and Fleischhack G
- Abstract
Recurrent medulloblastomas are associated with survival rates <10%. Adequate multimodal therapy is being discussed as having a major impact on survival. In this study, 93 patients with recurrent medulloblastoma treated in the German P-HIT-REZ 2005 Study were analyzed for survival (PFS, OS) dependent on patient, disease, and treatment characteristics. The median age at the first recurrence was 10.1 years (IQR: 6.9-16.1). Median PFS and OS, at first recurrence, were 7.9 months (CI: 5.7-10.0) and 18.5 months (CI: 13.6-23.5), respectively. Early relapses/progressions (<18 months, n = 30/93) found mainly in molecular subgroup 3 were associated with markedly worse median PFS (HR: 2.34) and OS (HR: 3.26) in regression analyses. A significant survival advantage was found for the use of volume-reducing surgery as well as radiotherapy. Intravenous chemotherapy with carboplatin and etoposide (ivCHT, n = 28/93) showed improved PFS and OS data and the best objective response rate (ORR) was 66.7% compared to oral temozolomide (oCHT, n = 47/93) which was 34.8%. Intraventricular ( n = 43) as well as high-dose chemotherapy ( n = 17) at first relapse was not related to a significant survival benefit. Although the results are limited due to a non-randomized study design, they may serve as a basis for future treatment decisions in order to improve the patients' survival.
- Published
- 2022
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32. Radiotherapy in Medulloblastoma-Evolution of Treatment, Current Concepts and Future Perspectives.
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Seidel C, Heider S, Hau P, Glasow A, Dietzsch S, and Kortmann RD
- Abstract
Medulloblastoma is the most frequent malignant brain tumor in children. During the last decades, the therapeutic landscape has changed significantly with craniospinal irradiation as the backbone of treatment. Survival times have increased and treatments were stratified according to clinical and later molecular risk factors. In this review, current evidence regarding the efficacy and toxicity of radiotherapy in medulloblastoma is summarized and discussed mainly based on data of controlled trials. Current concepts and future perspectives based on current risk classification are outlined. With the introduction of CSI, medulloblastoma has become a curable disease. Due to combination with chemotherapy, survival rates have increased significantly, allowing for a reduction in radiation dose and a decrease of toxicity in low- and standard-risk patients. Furthermore, modern radiotherapy techniques are able to avoid side effects in a fragile patient population. However, high-risk patients remain with relevant mortality and many patients still suffer from treatment related toxicity. Treatment needs to be continually refined with regard to more efficacious combinatorial treatment in the future.
- Published
- 2021
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33. Systemic chemotherapy of pediatric recurrent ependymomas: results from the German HIT-REZ studies.
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Adolph JE, Fleischhack G, Gaab C, Mikasch R, Mynarek M, Rutkowski S, Schüller U, Pfister SM, Pajtler KW, Milde T, Witt O, Bison B, Warmuth-Metz M, Kortmann RD, Dietzsch S, Pietsch T, Timmermann B, and Tippelt S
- Subjects
- Adolescent, Child, Child, Preschool, Germany, Humans, Sirolimus therapeutic use, Treatment Outcome, Brain Neoplasms drug therapy, Brain Neoplasms pathology, Ependymoma drug therapy, Ependymoma pathology, Neoplasm Recurrence, Local drug therapy
- Abstract
Purpose: Survival in recurrent ependymoma (EPN) depends mainly on the extent of resection achieved. When complete resection is not feasible, chemotherapy is often used to extend progression-free and overall survival. However, no consistent effect of chemotherapy on survival has been found in patients with recurrent EPN., Methods: Systemic chemotherapeutic treatment of 138 patients enrolled in the German HIT-REZ-studies was analyzed. Survival depending on the use of chemotherapy, disease-stabilization rates (RR), duration of response (DOR) and time to progression (TTP) were estimated., Results: Median age at first recurrence was 7.6 years (IQR: 4.0-13.6). At first recurrence, median PFS and OS were 15.3 (CI 13.3-20.0) and 36.9 months (CI 29.7-53.4), respectively. The Hazard Ratio for the use of chemotherapy in local recurrences in a time-dependent Cox-regression analysis was 0.99 (CI 0.74-1.33). Evaluable responses for 140 applied chemotherapies were analyzed, of which sirolimus showed the best RR (50%) and longest median TTP [11.51 (CI 3.98; 14.0) months] in nine patients, with the strongest impact found when sirolimus was used as a monotherapy. Seven patients with progression-free survival > 12 months after subtotal/no-resection facilitated by chemotherapy were found. No definitive survival advantage for any drug in a specific molecularly defined EPN type was found., Conclusion: No survival advantage for the general use of chemotherapy in recurrent EPN was found. In cases with incomplete resection, chemotherapy was able to extend survival in individual cases. Sirolimus showed the best RR, DOR and TTP out of all drugs analyzed and may warrant further investigation., (© 2021. The Author(s).)
- Published
- 2021
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34. Pretreatment central quality control for craniospinal irradiation in non-metastatic medulloblastoma : First experiences of the German radiotherapy quality control panel in the SIOP PNET5 MB trial.
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Dietzsch S, Braesigk A, Seidel C, Remmele J, Kitzing R, Schlender T, Mynarek M, Geismar D, Jablonska K, Schwarz R, Pazos M, Walser M, Frick S, Gurtner K, Matuschek C, Harrabi SB, Glück A, Lewitzki V, Dieckmann K, Benesch M, Gerber NU, Rutkowski S, Timmermann B, and Kortmann RD
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Cohort Studies, Female, Germany, Humans, Male, Prospective Studies, Quality Control, Radiation Oncology, Young Adult, Cerebellar Neoplasms radiotherapy, Craniospinal Irradiation methods, Medulloblastoma radiotherapy
- Abstract
Purpose: Several studies have demonstrated the negative impact of radiotherapy protocol deviations on tumor control in medulloblastoma. In the SIOP PNET5 MB trial, a pretreatment radiotherapy quality control (RT-QC) program was introduced. A first analysis for patients enrolled in Germany, Switzerland and Austria with focus on types of deviations in the initial plan proposals and review criteria for modern radiation technologies was performed., Methods and Patients: Sixty-nine craniospinal irradiation (CSI) plans were available for detailed analyses. RT-QC was performed according to protocol definitions on dose uniformity. Because of the lack of definitions for high-precision 3D conformal radiotherapy within the protocol, additional criteria for RT-QC on delineation and coverage of clinical target volume (CTV) and planning target volume (PTV) were defined and evaluated., Results: Target volume (CTV/PTV) deviations occurred in 49.3% of initial CSI plan proposals (33.3% minor, 15.9% major). Dose uniformity deviations were less frequent (43.5%). Modification of the RT plan was recommended in 43.5% of CSI plans. Unacceptable RT plans were predominantly related to incorrect target delineation rather than dose uniformity. Unacceptable plans were negatively correlated to the number of enrolled patients per institution with a cutoff of 5 patients (p = 0.001)., Conclusion: This prospective pretreatment individual case review study revealed a high rate of deviations and emphasizes the strong need of pretreatment RT-QC in clinical trials for medulloblastoma. Furthermore, the experiences point out the necessity of new RT-QC criteria for high-precision CSI techniques., (© 2020. The Author(s).)
- Published
- 2021
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35. Evaluation of Prognostic Factors and Role of Participation in a Randomized Trial or a Prospective Registry in Pediatric and Adolescent Nonmetastatic Medulloblastoma - A Report From the HIT 2000 Trial.
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Dietzsch S, Placzek F, Pietschmann K, von Bueren AO, Matuschek C, Glück A, Guckenberger M, Budach V, Welzel J, Pöttgen C, Schmidberger H, Heinzelmann F, Paulsen F, Escudero MP, Schwarz R, Hornung D, Martini C, Grosu AL, Stueben G, Jablonska K, Dunst J, Stranzl-Lawatsch H, Dieckmann K, Timmermann B, Pietsch T, Warmuth-Metz M, Bison B, Kwiecien R, Benesch M, Gerber NU, Grotzer MA, Pfister SM, Clifford SC, von Hoff K, Klagges S, Rutkowski S, Kortmann RD, and Mynarek M
- Abstract
Purpose: We aimed to compare treatment results in and outside of a randomized trial and to confirm factors influencing outcome in a large retrospective cohort of nonmetastatic medulloblastoma treated in Austria, Switzerland and Germany., Methods and Materials: Patients with nonmetastatic medulloblastoma (n = 382) aged 4 to 21 years and primary neurosurgical resection between 2001 and 2011 were assessed. Between 2001 and 2006, 176 of these patients (46.1%) were included in the randomized HIT SIOP PNET 4 trial. From 2001 to 2011 an additional 206 patients were registered to the HIT 2000 study center and underwent the identical central review program. Three different radiation therapy protocols were applied. Genetically defined tumor entity (former molecular subgroup) was available for 157 patients., Results: Median follow-up time was 7.3 (range, 0.09-13.86) years. There was no difference between HIT SIOP PNET 4 trial patients and observational patients outside the randomized trial, with 7 years progression-free survival rates (PFS) of 79.5% ± 3.1% versus 78.7% ± 3.1% ( P = .62). On univariate analysis, the time interval between surgery and irradiation (≤ 48 days vs ≥ 49 days) showed a strong trend to affect PFS (80.4% ± 2.2% vs 64.6% ± 9.1%; P = .052). Furthermore, histologically and genetically defined tumor entities and the extent of postoperative residual tumor influenced PFS. On multivariate analyses, a genetically defined tumor entity wingless-related integration site-activated vs non-wingless-related integration site/non-SHH, group 3 hazard ratio, 5.49; P = .014) and time interval between surgery and irradiation (hazard ratio, 2.2; P = .018) were confirmed as independent risk factors., Conclusions: Using a centralized review program and risk-stratified therapy for all patients registered to the study center, outcome was identical for patients with nonmetastatic medulloblastoma treated on and off the randomized HIT SIOP PNET 4 trial. The prognostic values of prolonged time to RT and genetically defined tumor entity were confirmed., (© 2020 The Authors.)
- Published
- 2020
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36. Management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the SIOPE radiotherapy working group.
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Hoeben BA, Carrie C, Timmermann B, Mandeville HC, Gandola L, Dieckmann K, Ramos Albiac M, Magelssen H, Lassen-Ramshad Y, Ondrová B, Ajithkumar T, Alapetite C, Balgobind BV, Bolle S, Cameron AL, Davila Fajardo R, Dietzsch S, Dumont Lecomte D, van den Heuvel-Eibrink MM, Kortmann RD, Laprie A, Melchior P, Padovani L, Rombi B, Scarzello G, Schwarz R, Seiersen K, Seravalli E, Thorp N, Whitfield GA, Boterberg T, and Janssens GO
- Subjects
- Child, Child, Preschool, Female, Humans, Male, Neoplasms pathology, Radiation Oncology standards, Neoplasms radiotherapy, Pediatrics standards, Radiotherapy Dosage standards, Radiotherapy, Conformal standards
- Abstract
Inhomogeneities in radiotherapy dose distributions covering the vertebrae in children can produce long-term spinal problems, including kyphosis, lordosis, scoliosis, and hypoplasia. In the published literature, many often interrelated variables have been reported to affect the extent of potential radiotherapy damage to the spine. Articles published in the 2D and 3D radiotherapy era instructed radiation oncologists to avoid dose inhomogeneity over growing vertebrae. However, in the present era of highly conformal radiotherapy, steep dose gradients over at-risk structures can be generated and thus less harm is caused to patients. In this report, paediatric radiation oncologists from leading centres in 11 European countries have produced recommendations on how to approach dose coverage for target volumes that are adjacent to vertebrae to minimise the risk of long-term spinal problems. Based on available information, it is advised that homogeneous vertebral radiotherapy doses should be delivered in children who have not yet finished the pubertal growth spurt. If dose fall-off within vertebrae cannot be avoided, acceptable dose gradients for different age groups are detailed here. Vertebral delineation should include all primary ossification centres and growth plates, and therefore include at least the vertebral body and arch. For partial spinal radiotherapy, the number of irradiated vertebrae should be restricted as much as achievable, particularly at the thoracic level in young children (<6 years old). There is a need for multicentre research on vertebral radiotherapy dose distributions for children, but until more valid data become available, these recommendations can provide a basis for daily practice for radiation oncologists who have patients that require vertebral radiotherapy., (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Published
- 2019
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37. Postoperative Adjuvant Lapatinib and Concurrent Chemoradiotherapy Followed by Maintenance Lapatinib Monotherapy in High-Risk Patients With Resected Squamous Cell Carcinoma of the Head and Neck: A Phase III, Randomized, Double-Blind, Placebo-Controlled Study.
- Author
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Harrington K, Temam S, Mehanna H, D'Cruz A, Jain M, D'Onofrio I, Manikhas G, Horvath Z, Sun Y, Dietzsch S, Dubinsky P, Holeckova P, El-Hariry I, Franklin N, Biswas-Baldwin N, Legenne P, Wissel P, Netherway T, Farrell J, Ellis C, Wang-Silvanto J, Amonkar M, Ahmed N, Santillana S, and Bourhis J
- Subjects
- Adult, Aged, Carcinoma, Squamous Cell metabolism, Cetuximab administration & dosage, Chemotherapy, Adjuvant, Cisplatin administration & dosage, Disease-Free Survival, Dose Fractionation, Radiation, Double-Blind Method, ErbB Receptors drug effects, ErbB Receptors genetics, Female, Head and Neck Neoplasms metabolism, Humans, International Cooperation, Kaplan-Meier Estimate, Lapatinib, Male, Middle Aged, Molecular Targeted Therapy, Odds Ratio, Squamous Cell Carcinoma of Head and Neck, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Squamous Cell therapy, Chemoradiotherapy, Head and Neck Neoplasms therapy, Maintenance Chemotherapy, Quinazolines therapeutic use
- Abstract
Purpose: This multicenter phase III study evaluated the efficacy and safety of lapatinib, an epidermal growth factor receptor/ErbB2 inhibitor, administered concomitantly with chemoradiotherapy and as maintenance monotherapy in patients with high-risk surgically treated squamous cell carcinoma of the head and neck (SCCHN)., Patients and Methods: Patients with resected stage II to IVA SCCHN, with a surgical margin ≤ 5 mm and/or extracapsular extension, were randomly assigned to chemoradiotherapy (66 Gy total radiation dose and cisplatin 100 mg/m(2) per day administered on days 1, 22, and 43) plus placebo or lapatinib (1,500 mg per day) before and during chemoradiotherapy, followed by 12 months of maintenance monotherapy., Results: Six hundred eighty-eight patients were enrolled (lapatinib, n = 346; placebo, n = 342). With a median follow-up time of 35.3 months, the study ended early because of the apparent plateauing of disease-free survival (DFS) events. Median DFS assessed by an independent review committee was 53.6 months and not reached for lapatinib and placebo, respectively (hazard ratio, 1.10; 95% CI, 0.85 to 1.43). Investigator-assessed results confirmed the independent review committee assessment. No significant differences in DFS by human papillomavirus status or overall survival were observed between treatment arms. Similar numbers of patients in both treatment arms experienced adverse events (AEs), with more patients in the lapatinib arm than the placebo arm experiencing serious AEs (48% v 40%, respectively). The most commonly observed treatment-related AEs were diarrhea and rash, both predominantly in the lapatinib arm., Conclusion: Addition of lapatinib to chemoradiotherapy and its use as long-term maintenance therapy does not offer any efficacy benefits and had additional toxicity compared with placebo in patients with surgically treated high-risk SCCHN., (© 2015 by American Society of Clinical Oncology.)
- Published
- 2015
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38. [Treatment related swallowing dysfunction and the potentialities of IMRT].
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Dietzsch S, Melzer R, Boehm A, Wolf U, Kortmann R, and Fuchs M
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- Chemoradiotherapy, Adjuvant, Combined Modality Therapy, Deglutition Disorders diagnostic imaging, Dose Fractionation, Radiation, Glottis diagnostic imaging, Humans, Imaging, Three-Dimensional, Larynx diagnostic imaging, Otorhinolaryngologic Neoplasms drug therapy, Pharyngeal Muscles diagnostic imaging, Radiation Injuries diagnostic imaging, Radiotherapy Planning, Computer-Assisted, Tomography, X-Ray Computed, Deglutition Disorders radiotherapy, Glottis radiation effects, Larynx radiation effects, Otorhinolaryngologic Neoplasms radiotherapy, Pharyngeal Muscles radiation effects, Radiation Injuries prevention & control, Radiotherapy, Intensity-Modulated
- Abstract
Altered fractionated radiotherapy and concurrent chemoradiation could improve local control and survival for patients with locally advanced head and neck cancer. However, intensified treatment seems to increase late toxicity. Late swallowing dysfunction is common and has a large impact on quality of life and can get life-threatening character. Recent studies could show interrelations between the radiation dose to certain anatomical structures involved in the swallowing process and the risk of swallowing dysfunction. Important structures seem to be the pharyngeal constrictors and the supraglottic and glottic larynx. Further prospective clinical validations using standardized diagnostic protocols for dysphagia are necessary to establish dose constraints to anatomical structures involved in swallowing., (© Georg Thieme Verlag KG Stuttgart · New York.)
- Published
- 2011
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39. Therapeutic options for treatment of Merkel cell carcinoma.
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Gessner K, Wichmann G, Boehm A, Reiche A, Bertolini J, Brus J, Sterker I, Dietzsch S, and Dietz A
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- Carcinoma, Merkel Cell pathology, Carcinoma, Merkel Cell surgery, Female, Follow-Up Studies, Humans, Middle Aged, Nose Neoplasms pathology, Nose Neoplasms surgery, Skin Neoplasms pathology, Skin Neoplasms surgery, Antineoplastic Agents therapeutic use, Carcinoma, Merkel Cell drug therapy, Cisplatin therapeutic use, Nose Neoplasms drug therapy, Skin Neoplasms drug therapy
- Abstract
Merkel cell carcinoma (MCC) is a rare malignant neuroendocrine carcinoma of the skin. Owing to the aggressiveness of this tumor and the bad overall survival, we reviewed the therapeutic strategies, including surgery, radiation, and chemotherapy to find out the potentially best treatment option for one patient treated at our hospital. In addition, we investigated MCC biopsies using the FLAVINO assay to find out if individual chemoresponse testing might be a useful supplement in decision-making for the optimal therapeutic option for our MCC patient. The different results achieved using cisplatin, docetaxel, and cetuximab led to the conclusion that an individual chemoresponse testing in a predictive short-time assay might potentially be a useful diagnostic tool in identifying potentially effective chemotherapy treatments.
- Published
- 2011
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40. [Laryngeal MALT lymphoma with known Sjögren syndrome].
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Fischer M, Horn IS, Bertolini J, Dietzsch S, Fuchs M, and Dietz A
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- Diagnosis, Differential, Female, Humans, Middle Aged, Treatment Outcome, Laryngeal Neoplasms diagnosis, Laryngeal Neoplasms therapy, Lymphoma, B-Cell, Marginal Zone diagnosis, Lymphoma, B-Cell, Marginal Zone therapy, Sjogren's Syndrome diagnosis, Sjogren's Syndrome therapy
- Abstract
Hematopoietic neoplasms represent about 1% of all laryngeal neoplasms. MALT lymphoma arises from mucosa-associated lymphoid tissue and is associated with chronic inflammatory disease. Patients with Sjögren syndrome have a higher risk for development of non-Hodgkin lymphoma (MALT lymphoma). To date, only cases of MALT lymphoma of the salivary glands, thymus and stomach associated with Sjögren syndrome have been published. We present the case of a MALT lymphoma of the larynx associated with Sjögren syndrome. Radiation and chemotherapy are the first line of therapy as published in the literature.
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- 2011
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41. Assay-based response evaluation in head and neck oncology: requirements for better decision making.
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Dietz A, Boehm A, Horn IS, Kruber P, Bechmann I, Golusinski W, Niederwieser D, Dollner R, Remmerbach TW, Wittekind C, Dietzsch S, Hildebrandt G, and Wichmann G
- Subjects
- Antineoplastic Agents pharmacology, Biopsy, Carcinoma, Squamous Cell pathology, Feasibility Studies, Head and Neck Neoplasms pathology, Humans, KB Cells drug effects, KB Cells pathology, Predictive Value of Tests, Reproducibility of Results, Salvage Therapy, Sensitivity and Specificity, Treatment Outcome, Carcinoma, Squamous Cell therapy, Combined Modality Therapy methods, Decision Making, Head and Neck Neoplasms therapy
- Abstract
This article gives an overview on different current strategies of assay-based response evaluation in head and neck squamous cell carcinomas (HNSCC) and critically summarizes their role and needs for future clinical evaluation. Due to a growing amount of data of phase III clinical trials of multimodality treatment options for HNSCC, treatment planning in regard to optimal outcome is becoming an interdisciplinary challenge. New concepts such as induction chemotherapy with bi- or ternary combinations of chemotherapeutics, integration of targeted therapies, concurrent and sequential chemoradiation concepts, and multimodality-based organ preservation strategies strongly compete with traditional definitive surgical procedures. Moreover, the outcome is difficult to predict due to heterogeneity of a tumor's response, impaired late functional outcome, and increased late toxicity if simultaneously applied to radiation. Retrospectively looking at non-responders with tumors classified as resectable, primary surgery is very likely to have achieved better results, since chemoradiation causes a high degree of early and late toxicities leading to extremely complicated terms and conditions in surgery following current multimodal therapeutic strategies. Unfortunately, predictive information on response characteristics of a given tumor before starting the therapy is not available in daily routine, although heterogeneity in response of a given tumor entity to treatments has been known for decades. Therefore, current therapy strategies for HNSCC still have to ignore this fact, creating an urgent need for the development of proper predictive assays. There are interesting clinical observations showing that response on induction chemotherapy may predict the outcome after radiotherapy. Some trials use this empiric phenomenon to pre-select non-responders for primary surgical treatment avoiding severe salvage complications after failure of complete chemoradiation treatment. Moving one step further, recent literature and our own investigations implicate that response evaluation of the individual patient's HNSCC in a suitable ex vivo assay just before starting the treatment is mature for clinical research. To this end, essential needs and hints are addressed and discussed.
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- 2010
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42. Molecular mechanisms of hyperthermia- and cisplatin-induced cytotoxicity in T cell leukemia.
- Author
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Mauz-Körholz C, Dietzsch S, Schippel P, Banning U, and Körholz D
- Subjects
- Apoptosis drug effects, Apoptosis physiology, Caspase 3, Caspase 6, Caspase Inhibitors, Caspases metabolism, Cisplatin pharmacokinetics, Enzyme Activation drug effects, Humans, Leukemia, T-Cell drug therapy, Leukemia, T-Cell enzymology, Leukemia, T-Cell pathology, Tumor Cells, Cultured, Antineoplastic Agents pharmacology, Cisplatin pharmacology, Hyperthermia, Induced methods, Leukemia, T-Cell therapy
- Abstract
Background: The prognosis of early and very early relapse in acute lymphoblastic leukemia of childhood is still very poor unless a hematopoietic stem cell transplant is performed if a second remission can be achieved by induction chemotherapy. Therefore an intensification of chemotherapy is required., Materials and Methods: In the present study the molecular mechanisms of cisplatin- and/or hyperthermia-mediated cytotoxicity in CEM cells, a human T leukemia cell line, were investigated., Results: Both hyperthermia and cisplatin induced the activation of the effector caspases-3 and -6. However, caspase activation followed different time kinetics. While hyperthermia exerted maximum caspase activation immediately after application, cisplatin activated caspase-3 and -6 after 24 hours. At both time-points significant caspase-3 and -6 activation was observed when the cells were stimulated by a combination of heat and cisplatin. The application of z-VAD-fmk, a general caspase inhibitor, showed that hyperthermia mediated cytotoxicity mainly via caspase-dependent mechanisms, while cisplatin induced both caspase-dependent and -independent cytotoxicity. Time kinetic experiments revealed that hyperthermia induced cell death immediately after the heating pulse. In contrast, cisplatin-induced cell death had its maximum between 6 hours and 12 hours after the heating pulse. The combined application of heat and cisplatin induced two peaks of cytotoxicity, one immediately after the heating pulse and the other between 6 hours and 12 hours., Conclusion: Hyperthermia and cisplatin induced cell death in T leukemic cells by different molecular mechanisms, which might explain the enhanced cisplatin-induced cytotoxicity by hyperthermia.
- Published
- 2003
43. Mechanisms of hyperthermia- and 4-hydroperoxy-ifosfamide-induced cytotoxicity in T cell leukemia.
- Author
-
Mauz-Körholz C, Dietzsch S, Banning U, Tröbs RB, and Körholz D
- Subjects
- Caspase 3, Caspase 6, Caspases metabolism, Cell Death drug effects, Combined Modality Therapy, Drug Synergism, Enzyme Activation drug effects, Humans, Kinetics, Leukemia, T-Cell drug therapy, Antineoplastic Agents, Alkylating pharmacology, Hyperthermia, Induced methods, Ifosfamide analogs & derivatives, Ifosfamide pharmacology, Leukemia, T-Cell therapy
- Abstract
The prognosis of patients with early ALL (acute lymphoblastic leukaemia) relapse is poor with conventional chemotherapy alone. Thus, intensified chemotherapy strategies are required. The application of hyperthermia enhances the efficacy of certain antineoplastic drugs such as ifosfamide. In this study, the effects and molecular mechanisms of ifosfamide (4hydroperoxy-ifosfamide = 4OOH-IFA)- and/or hyperthermia-induced cell death are investigated in CEM cells. Hyperthermia enhanced the efficacy of 4OOH-IFA in a subaddictive manner. Analysis of caspase activation revealed an early hyperthermia-induced stimulation of caspase-3 and -6 directly after the heating pulse, while maximum activation following stimulation with 4OOH-IFA was obtained after 24 hours of culture. The combination of 4OOH-IFA and hyperthermia mediated an overaddictive caspase stimulation directly following the heating phase. At this time also an overaddictive cytotoxic effect was noticed, being mainly responsible for the enhancing effects of hyperthermia on 4OOH-IFA cytotoxicity. In conclusion, hyperthermia enhanced the cytotoxic effect of 4OOH-IFA on CEM cells by stimulation of an early 4OOH-IFA effect. Thus, thermochemotherapy might be considered as an intensifying treatment option in relapsed T cell leukemias.
- Published
- 2002
44. ["Parent centered" group work as a possibility in parent counseling in child psychotherapy].
- Author
-
Knöpfel M and Dietzsch S
- Subjects
- Adult, Child, Child Behavior Disorders psychology, Defense Mechanisms, Humans, Neurotic Disorders psychology, Parent-Child Relations, Child Behavior Disorders rehabilitation, Neurotic Disorders rehabilitation, Parents psychology, Psychotherapy methods, Psychotherapy, Group methods
- Abstract
Neurotic disturbances in children can be largely explained by pathogenic attitudes of the parents. Disappointment, guilt and helplessness are neutralised or denied by a multitude of defence mechanisms. The advisory service for parents is concerned with the task to dissolve these defence mechanism and to relieve the disturbed parents-child relations. According to the authors' opinion, parents can arrive at a "child-centred" attitude when the therapist, too, is experienced in his attitude as "child-and-parents-centred". In the group work with parents, a combination of talk groups with "supplementary methods" after Brocher and training groups according to the "defeatless method of conflict overcoming" after Gordon has proved to be suitable. Practical approach and experiences are described.
- Published
- 1981
45. [Activity of the psychologist within the inpatient psychotherapy of behavior disordered children and adolescents].
- Author
-
Dietzsch S
- Subjects
- Adolescent, Child, Germany, East, Humans, Interprofessional Relations, Neurotic Disorders therapy, Therapeutic Community, Child Behavior Disorders therapy, Psychology, Child, Psychotherapy methods, Residential Treatment methods
- Abstract
The author, after discussing the problem of cooperation between the physician and psychologist within the framework of psychotherapeutic activity, deals with the special functions of psychologists. Work done in this respect at the Dresden Medical Academy's department for psychotherapy of malbehaving children and juveniles of normal intelligence is described. Also outlined in this paper are the role played by the psychologist in the use of various methods of therapy and his cooperation in the continuing education and training of nurses, the psychometric control of the course of therapy, and the rehabilitation of children and juveniles.
- Published
- 1978
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