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An increasing interest in a healthy lifestyle raises questions about optimal body weight. Evidently, it should be clearly discriminated between the standardised “normal” body weight and individually optimal weight. To this end, the basic principle of personalised medicine “one size does not fit all” has to be applied. Contextually, “normal” but e.g. borderline body mass index might be optimal for one person but apparently suboptimal for another one strongly depending on the individual genetic predisposition, geographic origin, cultural and nutritional habits and relevant lifestyle parameters—all included into comprehensive individual patient profile. Even if only slightly deviant, both overweight and underweight are acknowledged risk factors for a shifted metabolism which, if being not optimised, may strongly contribute to the development and progression of severe pathologies. Development of innovative screening programmes is essential to promote population health by application of health risks assessment, individualised patient profiling and multi-parametric analysis, further used for cost-effective targeted prevention and treatments tailored to the person. The following healthcare areas are considered to be potentially strongly benefiting from the above proposed measures: suboptimal health conditions, sports medicine, stress overload and associated complications, planned pregnancies, periodontal health and dentistry, sleep medicine, eye health and disorders, inflammatory disorders, healing and pain management, metabolic disorders, cardiovascular disease, cancers, psychiatric and neurologic disorders, stroke of known and unknown aetiology, improved individual and population outcomes under pandemic conditions such as COVID-19. In a long-term way, a significantly improved healthcare economy is one of benefits of the proposed paradigm shift from reactive to Predictive, Preventive and Personalised Medicine (PPPM/3PM). A tight collaboration between all stakeholders including scientific community, healthcare givers, patient organisations, policy-makers and educators is essential for the smooth implementation of 3PM concepts in daily practice.

Symptoms and signs of Flammer Syndrome (FS) usually appear in puberty. Appearance of the FS symptoms early in life is an extremely important indication for predictive and preventive measures to be considered by innovative concepts of predictive, preventive and personalised medicine (PPPM) and applied individually according to the patient profile of the affected person. This chapter provides the room for an opinion of experienced psychiatrists to consider facts and to demonstrate their vision in the area, at which time point the FS phenotype is getting evident and how innovative PPPM concepts might be applied to daily medical practice by selecting FS affected individuals at early stage of the phenotype development in teenagers optimising the environmental influence on development of the personality profile (family and school) and avoiding unhealthy behavioural habits such as “disordered eating” and clinical onset of the associated pathologies such as eating disorders (anorexia nervosa, bulimia) and mood and mental disorders (depression as an example).

Zusammenfassung. Ausgangspunkt der Untersuchung sind Studien, in denen psychisch gestörte Kinder und Jugendliche zu ihrer Lebensqualität befragt wurden. Die vorliegende Studie ist der Frage nachgegangen, ob sich ähnliche Ergebnisse zeigen, wenn die Eltern von psychisch gestörten Kindern und Jugendlichen zur Lebensqualität ihrer Kinder befragt werden. Hierzu wurden 604 Eltern von ambulant und stationär behandelten kinder- und jugendpsychiatrischen Patienten die Elternversion des Inventars zur Erfassung der Lebensqualität bei Kindern und Jugendlichen (ILK-Elternbogen) vorgelegt. Ergebnisse: (1) Auch bei den Elternangaben sind die Ergebnisse bei stationären Patienten auf allen ILK-Skalen ungünstiger als bei den ambulanten Patienten. Darüber hinaus zeigen sich bei einer Reihe von Skalen signifikante Alters- und Geschlechtseffekte. (2) Die Eltern fühlen sich selbst durch die aktuelle Problematik des Kindes/Jugendlichen und durch die Tatsache, dass ihr Kind/Jugendlicher behandelt wird, zu einem hohen Prozentsatz erheblich beeinträchtigt; die entsprechenden Beeinträchtigungen der Kinder bzw. Jugendlichen werden von den Eltern als weniger gravierend beschrieben. Bei der Planung der therapeutischen Maßnahmen sollte die Frage nach der Lebensqualität der Kinder und ihrer Eltern stärker berücksichtigt werden, um die Effektivität der therapeutischen Interventionen zu erhöhen.