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BackgroundThe double burden of malnutrition and diet-related disease has been attributed to diets high in ultra-processed and discretionary foods, with increased sugars, saturated fats, and sodium, and insufficient dietary fibre. There is a limited understanding of the role of other macronutrients and micronutrients.ObjectiveDetermine the highest priority nutrients to address both malnutrition and diet-related disease in Australia and New Zealand, for each demographic group and the total population.MethodsA novel four-step methodological approach was undertaken to identify: 1. Demographic (age-sex) groups; 2. Health priorities; 3. Potential nutrients based on inadequacy, increased requirements, and health priority association; and 4. Priority nutrients. Nutrient intake data was obtained from the most recent Australian and New Zealand nutrition surveys. Health priorities were based on national statistical data and expert consultation. High-level scientific literature (systematic reviews) was scoped for associations with health priorities and the suitability of recommended intakes. A quantitative scoring matrix was developed and used to determine the highest priority nutrients, with scoring over three domains: extent of inadequacy; consensus for increased requirements; and degree of association with health priorities.ResultsNutritional inadequacies were common, with 22 of 31 essential nutrients consumed below recommended levels. Nine priority nutrients were identified across the demographic groups, with each demographic group characterised by a specific subset of these. Six nutrients were highest priority within the total population: vitamin D, calcium, omega-3 fatty acids, magnesium, folate, dietary fibre.ConclusionThe extent of nutritional inadequacies in Australia and New Zealand is high, both within each demographic group and the entire population, relative to both recommended intakes and key health outcomes. The methodology can be applied to other countries and globally. Findings make a significant contribution to understanding the nutrients to prioritise in future-proofing the health of the Australian and New Zealand populations. Guidelines and policies can target priority nutrients to address the malnutrition and diet-related disease double burden.

Produce prescription programs aim to improve food insecurity (FI) and nutrition but their effectiveness is unclear. We conducted a pilot study to demonstrate the feasibility and explore the potential impact of a family-based, home-delivery produce prescription and nutrition education program. We measured enrollment, satisfaction, participation, and retention as measure of feasibility. Adult participants answered pre-post self-report questionnaires assessing FI, child and adult fruit and vegetable intake, and culinary literacy and self-efficacy. To understand participants' lived experiences, qualitative interviews were conducted at the 6-month time point. Twenty-five families were enrolled. Feasibility measures indicate participants were generally satisfied with the program but there were important barriers to participation. Qualitative data revealed themes around reduced food hardship, healthy eating, budget flexibility, and family bonding. Fruit and vegetable consumption increased in a small subgroup of children, but post-intervention intake remained below recommended levels, particularly for vegetables. FI scores were not significantly different post-intervention, but qualitative findings indicated improved access and reliability of food. This is the first intervention of its kind to be evaluated for feasibility and our results suggest the intervention is well-received and supportive. However, further study, with a larger sample size, is needed to understand factors influencing participation and assess effectiveness. [ABSTRACT FROM AUTHOR]

Cancer-related fatigue (CRF) is considered one of the most frequent and distressing symptoms for cancer survivors. Despite its high prevalence, factors that predispose, precipitate, and perpetuate CRF are poorly understood. Emerging research focuses on cancer and treatment-related nutritional complications, changes in body composition, and nutritional deficiencies that can compound CRF. Nutritional metabolomics, the novel study of diet-related metabolites in cells, tissues, and biofluids, offers a promising tool to further address these research gaps. In this position paper, we examine CRF risk factors, summarize metabolomics studies of CRF, outline dietary recommendations for the prevention and management of CRF in cancer survivorship, and identify knowledge gaps and challenges in applying nutritional metabolomics to understand dietary contributions to CRF over the cancer survivorship trajectory. [ABSTRACT FROM AUTHOR]

North Carolina Extension specialists conducted a needs assessment of Family and Consumer Sciences (FCS) agents to determine their foods and nutrition programming needs. Researchers examined agent and community needs, agent-offered programming, and barriers and facilitators to program implementation. Results will help inform the development of targeted agent trainings, materials, programs, and technical assistance related to foods and nutrition. The study is intended to help maximize the success of FCS foods and nutrition programming by supporting agents in delivering high-quality, evidence-based programs. This paper reviews study implementation, results, and relevant implications for other Extension professionals interested in performing a similar analysis.

Aim: Although poor oral health has been a potentially modifiable risk for mortality, the precise association between functional tooth units (FTUs) and premature death as well as the underlying mechanisms remains unclear., Methods: This study used data from the National Health and Nutrition Examination Survey (NHANES) 2009-2018. Mortality details were obtained from the National Death Index (NDI). The number of FTUs was defined as pairs of opposing natural and artificial teeth in the premolar and molar area. Weighted logistic regression models were employed to assess the relationship between FTU and premature death. Demographic characteristics, lifestyle habits, and disease histories were adjusted as confounding factors. The propensity score matching (PSM) was conducted to further assess the association between FTU and premature death. Mediation analyses were conducted to assess the role of diet-related diseases in the association between FTU and premature death., Results: The analysis included 4169 individuals aged between 60 and 74 years. Participants with 0 ≤ FTUs ≤ 3 had a significantly higher odds of premature death compared to the 10 ≤ FTUs ≤ 12 group (OR = 2.142, 95% CI 1.091-4.208). After missing data imputation, 0 ≤ FTUs ≤ 3 was still significantly associated with increased odds of premature death (OR = 2.115, 95% CI 1.125-3.975). The relationship between 0 ≤ FTUs ≤ 3 and reference group persisted (OR = 2.196, 95% CI 1.296-3.721) after PSM analyses. For mechanism, mediation analysis showed that diet-related diseases, including diabetes and hypertension, partially mediated the association between FTU and premature death with proportions of 5.089% and 8.437%, respectively., Conclusion: The findings revealed a link between impairment of masticatory function and a heightened odds of premature death among older adults. Notably, 0 ≤ FTUs ≤ 3 is significantly correlated to premature death among this demographic, with diabetes and hypertension partially mediating the effect of FTU on premature death. Further longitudinal studies are required to validate the findings., (© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Objectives: To examine the health effects of the Supplemental Nutritional Assistance Program (SNAP) and the differential impact of SNAP across race/ethnicity among older adults. Data Source/Study Setting: 2008-2013 Medical Expenditure Panel Survey, a nationally representative population-based complex sample survey. Study Design: A difference-in-regression-discontinuity (DRD) design is used to assess the impacts of SNAP on diet-related disease morbidity. The primary outcomes were the prevalence rate of hypertension, coronary heart disease, stroke, diabetes, and cancer. We also conducted supplemental analysis to examine potential co-occurring trends in medical utilization. Data Collection/Extraction Methods: Data are publicly available. Principal Findings: In the full sample, SNAP eligibility was associated with a significant decline in diabetes (-3.71 percentage points [pp]; P < .05). Non-Hispanic (NH) White respondents reported trends similar to the full sample; however, NH Black respondents reported large declines in hypertension (-13.95 pp; P < .01) and Hispanic respondents reported declines in the prevalence of angina (-6.94 pp; P < .05) and stroke (-4.48 pp; P < .05). Conclusions: Supplemental Nutritional Assistance Program eligibility was associated with the reduced prevalence of diet-related disease among older adults. These observed declines in the prevalence of diet-related disease do not appear to be attributable to increased medical visits or spending on medical services and prescriptions. [ABSTRACT FROM AUTHOR]

Background: The double burden of malnutrition and diet-related disease has been attributed to diets high in ultra-processed and discretionary foods, with increased sugars, saturated fats, and sodium, and insufficient dietary fibre. There is a limited understanding of the role of other macronutrients and micronutrients., Objective: Determine the highest priority nutrients to address both malnutrition and diet-related disease in Australia and New Zealand, for each demographic group and the total population., Methods: A novel four-step methodological approach was undertaken to identify: 1. Demographic (age-sex) groups; 2. Health priorities; 3. Potential nutrients based on inadequacy, increased requirements, and health priority association; and 4. Priority nutrients. Nutrient intake data was obtained from the most recent Australian and New Zealand nutrition surveys. Health priorities were based on national statistical data and expert consultation. High-level scientific literature (systematic reviews) was scoped for associations with health priorities and the suitability of recommended intakes. A quantitative scoring matrix was developed and used to determine the highest priority nutrients, with scoring over three domains: extent of inadequacy; consensus for increased requirements; and degree of association with health priorities., Results: Nutritional inadequacies were common, with 22 of 31 essential nutrients consumed below recommended levels. Nine priority nutrients were identified across the demographic groups, with each demographic group characterised by a specific subset of these. Six nutrients were highest priority within the total population: vitamin D, calcium, omega-3 fatty acids, magnesium, folate, dietary fibre., Conclusion: The extent of nutritional inadequacies in Australia and New Zealand is high, both within each demographic group and the entire population, relative to both recommended intakes and key health outcomes. The methodology can be applied to other countries and globally. Findings make a significant contribution to understanding the nutrients to prioritise in future-proofing the health of the Australian and New Zealand populations. Guidelines and policies can target priority nutrients to address the malnutrition and diet-related disease double burden., Competing Interests: CS, TC, EB, and FF-M independently work for FOODiQ Global, which gains funding for projects from government, not-for-profits, professional, community, and industry organisations. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Starck, Cassettari, Beckett, Marshall and Fayet-Moore.)

Objective Maillard advanced glycation end products (AGEs) are connected with high dry temperature food processing, color and flavor modification of food products. Oral cavity pathology is strongly influenced by dietary intake. The aim of the present paper is to update current data regarding the sources and metabolism of AGEs, their impact on oral cavity tissues, to discuss and suggest new approaches for the early diagnosis and efficient treatment of AGEs-related oral pathology. Design This paper is a narrative review of the studies discussing AGEs and mainly the dietary AGEs (dAGEs) sources, metabolism, linkage to general diseases, and specifically the oral cavity pathology. The authors used "PUBMED" and MeSH for the finding of English written and published articles concerning AGEs. There were used the next keywords association: “advanced glycation end products- AGEs” AND “Maillard products”, “AGEs” AND “diet-related disease, “AGEs” AND “salivary biosensor”, “AGEs” AND “metabolic syndrome AGEs”, “AGEs” AND “oral pathology”, “AGEs” AND “dentin AGEs” OR “periodontal AGEs”, “AGEs” AND “diagnosis and monitoring”. The authors used free full-text articles to determine the etiology and physiopathology of AGEs, their association with general diseases and oral cavity disease, assessment methods used in biofluids and tissues, AGEs prevention and treatment approaches. Articles concerning AGEs etiology, metabolism and effect in the human body and specific implication in oral pathology were selected. There were no exclusion criteria in what concerns the study design. Studies in other language than English and articles abstracts were excluded. Criteria of inclusion were free full-text articles written in English. Equally human and animal model studies were included. Regarding the date of publication, all subjects concerning glycation products after 1953 (first published article) were included. Results Evidence show that AGEs are responsible for inducing low intensity chronic inflammation and thereby, for initiating and/or aggravating chronic diseases. Nowadays, research has demonstrated a significant association between AGEs and dental or periodontal pathology. Moreover, salivary AGEs are consistent with the levels of AGEs in other biological fluids and are correlated with the general and oral pathology. Conclusions Assessment of salivary AGEs could be a reliable tool for early diagnosis and monitoring diet-related disease. [ABSTRACT FROM AUTHOR]

Metabolomics focuses on the global study of metabolites in cells, tissues and biofluids. Analytical technologies such as nuclear magnetic resonance ( NMR) spectroscopy and hyphenated mass spectrometry ( MS) combined with advanced multivariate statistical methods allow us to study perturbations in metabolism. The close link between metabolism and nutrition has seen the application of metabolomics in nutritional research increase in recent times. Such applications can be divided into three main categories, namely (1) the area of dietary biomarker identification, (2) diet-related diseases and (3) nutritional interventions. The present perspective gives an overview of these applications and an outlook to the future. © 2015 Society of Chemical Industry [ABSTRACT FROM AUTHOR]

The US food system functions within a complex nexus of social, political, economic, cultural, and ecological factors. Among them are many dynamic pressures such as population growth, urbanization, socioeconomic inequities, climate disruption, and the increasing demand for resource-intensive foods that place immense strains on public health and the environment. This review focuses on the role that policy plays in defining the food system, particularly with regard to agriculture. It further examines the challenges of making the food supply safe, nutritious, and sustainable, while respecting the rights of all people to have access to adequate food and to attain the highest standard of health. We conclude that the present US food system is largely unhealthy, inequitable, environmentally damaging, and insufficiently resilient to endure the impacts of climate change, resource depletion, and population increases, and is therefore unsustainable. Thus, it is imperative that the US embraces policy reforms to transform the food system into one that supports public health and reflects the principles of human rights and agroecology for the benefit of current and future generations. [ABSTRACT FROM AUTHOR]

Highlights: [•] Mass spectrometry-based metabolomics applied to study diet-related diseases. [•] Selected biomarkers aid understanding of disease mechanisms. [•] Different analytical platforms (CE–MS, GC–MS, LC–MS) offer different information. [•] Integrated biology (different omics) reveals more information on pathway regulation. [Copyright &y& Elsevier]

Objectives. To calculate the energy and nutrient intake in 2 regions of Alaska and to describe the implications for development of chronic disease among Alaska Native people (AN). Study design. Cross-sectional observation; 10 villages and 2 hub communities in rural Alaska; 333 participants ages 13 to 88 years old. Methods. Trained interviewers collected 24-hour diet recalls during 4 seasons. Results. In both regions, AN reported a combination of traditional Native foods and store bought foods; most of the energy comes from store-bought foods; a high proportion of nutrients come from Native foods, especially protein, iron and omega-3 fatty acids. Mean intakes of omega-3 fatty acids, from fish and sea mammals, are over twenty times greater than those of the general U.S. population. Mean intakes of protein, iron, selenium, vitamin A, vitamin C (men) and folate (men) met recommended levels; intakes of calcium and fiber were below recommended levels; carbohydrate and saturated fat (% energy) were above. Conclusions. Traditional foods continue to contribute a significant amount of nutrients to the diet in rural Alaska. Excess simple sugars may be contributing to the rise in obesity and diabetes. Low intakes of calcium, dietary fiber, fruits and vegetables may contribute to the increased incidence of cancers of the digestive system. Emphasis on the positive aspects of Native foods and increased consumption of fruits, vegetables and calcium-rich foods are warranted. [ABSTRACT FROM AUTHOR]

The issue of access to healthy foods has been central to the work of many community-based organizations around the country. One such organization, The Food Trust, launched an effective advocacy campaign to bring awareness and policy change to the issue. The Food Trust's efforts with its partners resulted in the creation of the Pennsylvania Fresh Food Financing Initiative, the nation's first statewide financing program to increase supermarket development in underserved areas. This article focuses on a key component of the advocacy campaign: the creation of an evidence-based report that served as a strong, credible foundation for the campaign. The steps that were taken to find partners, obtain and analyze the data, and disseminate the findings are described. In addition, the outcomes of the Fresh Food Financing Initiative are discussed. [ABSTRACT FROM AUTHOR]

• Food deserts are hypothesized to negatively affect health and increase the incidence of diet-related disease. • The elderly may be particularly susceptible to any harmful effects of food deserts. • Elderly food desert residents have relatively similar health outcomes as those living outside food deserts. • Elderly residents of low-access census tracts with a child living nearby are less likely to report fair or poor health. • Food deserts are not a contributor to poor health among low-income elderly Americans. It is hypothesized that residents of neighborhoods with limited access to affordable and nutritious food face greater barriers to eating a healthy diet, which may in turn, result in worse health outcomes for them. Low-income elderly in urban areas may be uniquely affected by these so-called "food deserts" due to limited transportation options, strong attachments to local neighborhoods, fixed incomes, physical limitations in food shopping and meal preparation, and chronic health problems. Using the 2006, 2010, and 2014 waves of the Health and Retirement Study (HRS), the association between the food environment of elderly individuals living in urban Census tracts and their diet-related health was examined. Within urban areas, we find little evidence that food deserts negatively impact the health of lower income elderly individuals. Policies to address the needs of elderly residents of food deserts should be narrowly targeted and carefully justified. [ABSTRACT FROM AUTHOR]

Advanced glycation end products (AGEs) are glycated proteins associated with high dry temperature food processing, coloring and flavor modification of food products. Previous studies on diet-related disease support the role of the glycation products as biomarkers in local and general proinflammatory response. Exogenous and endogenous AGEs are involved in chronic low-level inflammation, which underlies the onset of metabolic syndrome influenced by food intake, there by demonstrating their implication in diet-related pathologies. Although studies have revealed a strong association between the accumulation of AGEs and the occurrence/worsening of metabolic diseases, their routine use for the diagnosis or monitoring of local and general disease has not yet been reported.