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183 results on '"Diener, M. K."'

16. Meta-analysis of randomized controlled trials and individual patient data comparing minimally invasive with open oesophagectomy for cancer

Author

Müller-Stich, B. P., primary, Probst, P., additional, Nienhüser, H., additional, Fazeli, S., additional, Senft, J., additional, Kalkum, E., additional, Heger, P., additional, Warschkow, R., additional, Nickel, F., additional, Billeter, A.T., additional, Grimminger, P. P., additional, Gutschow, C., additional, Dabakuyo-Yonli, T. S., additional, Piessen, G., additional, Paireder, M., additional, Schoppmann, S. F., additional, van der Peet, D. L., additional, Cuesta, M. A., additional, van der Sluis, P., additional, van Hillegersberg, R., additional, Hölscher, A. H., additional, Diener, M. K., additional, and Schmidt, T., additional

Published
2021
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26. Quere- versus Längslaparotomie — Eine randomisiert verblindete Studie

Author

Seiler, Christoph M., Deckert, A., Diener, M. K., Knaebel, H. -P., Weigand, M. A., Victor, N., Büchler, M. W., Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Senninger, N., editor, Allgayer, H., editor, Bruns, C. J., editor, Celik, I., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Germann, G., editor, Haas, N., editor, Langer, S., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Fitze, G., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Neuhaus, P., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Steinsträßer, L., editor, Vogt, P., editor, Arbogast, R., editor, and Bauer, H., editor

Published
2008
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27. Einfluss des Pringle-Manövers auf Morbidität und Mortalität nach Leberresektion — eine systematische Übersichtsarbeit mit Meta-Analyse

Author

Rahbari, Nuh N., Wente, M. N., Schemmer, P., Diener, M. K., Hoffmann, K., Motschall, E., Schmidt, J., Weitz, J., Büchler, M. W., Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Senninger, N., editor, Allgayer, H., editor, Bruns, C. J., editor, Celik, I., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Germann, G., editor, Haas, N., editor, Langer, S., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Fitze, G., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Neuhaus, P., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Steinsträßer, L., editor, Vogt, P., editor, Arbogast, R., editor, and Bauer, H., editor

Published
2008
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35. Learning Curves of Laparoscopic Roux-en-Y Gastric Bypass and Sleeve Gastrectomy in Bariatric Surgery: a Systematic Review and Introduction of a Standardization

Author

Wehrtmann, F. S., primary, de la Garza, J. R., additional, Kowalewski, K. F., additional, Schmidt, M. W., additional, Müller, K., additional, Tapking, C., additional, Probst, P., additional, Diener, M. K., additional, Fischer, L., additional, Müller-Stich, B. P., additional, and Nickel, F., additional

Published
2019
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38. Outcomes and Risk Score for Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) : An International Multicenter Analysis

Author

Klompmaker, S., Peters, N. A., van Hilst, J., Bassi, C., Boggi, U., Busch, O. R., Niesen, W., Van Gulik, T. M., Javed, A. A., Kleeff, J., Kawai, M., Lesurtel, M., Lombardo, C., Moser, A. J., Okada, K. -I., Popescu, I., Prasad, R., Salvia, R., Sauvanet, A., Sturesson, C., Weiss, M. J., Zeh, H. J., Zureikat, A. H., Yamaue, H., Wolfgang, C. L., Hogg, M. E., Besselink, M. G., Gerritsen, S. L., Adham, M., Albiol Quer, M. T., Berrevoet, F., Cesaretti, M., Dalla Valle, R., Darnis, B., Diener, M. K., Del Chiaro, M., Hackert, T. H., Grutzmann, R., Dumitrascu, T., Friess, H., Hirono, S., Ivanecz, A., Karayiannakis, A., Fusai, G. K., Labori, K. J., Lopez-Ben, S., Mabrut, J. -Y., Miyazawa, M., Pardo, F., Perinel, J., Roeyen, G., Graduate School, CCA - Cancer Treatment and Quality of Life, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, AGEM - Endocrinology, metabolism and nutrition, Surgery, CCA - Cancer biology and immunology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and E-AHPBA DP-CAR Study Grp

Subjects
Male, medicine.medical_specialty, Pancreatic Neoplasms/pathology, SURGERY, medicine.medical_treatment, Pancreatectomy/mortality, Pancreatectomy, Celiac artery, Celiac Artery, Pancreatic cancer, medicine.artery, Medicine and Health Sciences, Aged, Female, Follow-Up Studies, Humans, Middle Aged, Pancreatic Neoplasms, Retrospective Studies, Survival Rate, Treatment Outcome, Patient Selection, Journal Article, Medicine, Survival rate, ARTERY, Framingham Risk Score, business.industry, Mortality rate, Celiac Artery/surgery, ADENOCARCINOMA, Retrospective cohort study, medicine.disease, Surgery, ddc, MODEL, Multicenter Study, DEFINITION, Oncology, Hepatobiliary Tumors, VOLUME, Adenocarcinoma, Human medicine, business
Abstract

Background Distal pancreatectomy with celiac axis resection (DP-CAR) is a treatment option for selected patients with pancreatic cancer involving the celiac axis. A recent multicenter European study reported a 90-day mortality rate of 16%, highlighting the importance of patient selection. The authors constructed a risk score to predict 90-day mortality and assessed oncologic outcomes. Methods This multicenter retrospective cohort study investigated patients undergoing DP-CAR at 20 European centers from 12 countries (model design 2000–2016) and three very-high-volume international centers in the United States and Japan (model validation 2004–2017). The area under receiver operator curve (AUC) and calibration plots were used for validation of the 90-day mortality risk model. Secondary outcomes included resection margin status, adjuvant therapy, and survival. Results For 191 DP-CAR patients, the 90-day mortality rate was 5.5% (95 confidence interval [CI], 2.2–11%) at 5 high-volume (≥ 1 DP-CAR/year) and 18% (95 CI, 9–30%) at 18 low-volume DP-CAR centers (P = 0.015). A risk score with age, sex, body mass index (BMI), American Society of Anesthesiologists (ASA) score, multivisceral resection, open versus minimally invasive surgery, and low- versus high-volume center performed well in both the design and validation cohorts (AUC, 0.79 vs 0.74; P = 0.642). For 174 patients with pancreatic ductal adenocarcinoma, the R0 resection rate was 60%, neoadjuvant and adjuvant therapies were applied for respectively 69% and 67% of the patients, and the median overall survival period was 19 months (95 CI, 15–25 months). Conclusions When performed for selected patients at high-volume centers, DP-CAR is associated with acceptable 90-day mortality and overall survival. The authors propose a 90-day mortality risk score to improve patient selection and outcomes, with DP-CAR volume as the dominant predictor. Electronic supplementary material The online version of this article (10.1245/s10434-018-07101-0) contains supplementary material, which is available to authorized users.

Published
2019

47. Systematic review of the quantity and quality of randomized clinical trials in pancreatic surgery.

Author

Hüttner, F. J., Capdeville, L., Pianka, F., Ulrich, A., Hackert, T., Büchler, M. W., Probst, P., and Diener, M. K.

Subjects
PANCREATIC surgery, RANDOMIZED controlled trials, QUALITY of life, CLINICAL medicine research, ECONOMICS
Abstract

Background: RCTs are considered the reference standard in clinical research. However, surgical RCTs pose specific challenges and therefore numbers have been lower than those for randomized trials of medical interventions. In addition, surgical trials have often been associated with poor methodological quality. The objective of this study was to evaluate the evolution of quantity and quality of RCTs in pancreatic surgery and to identify evidence gaps. Methods: PubMed, CENTRAL and Web of Science were searched systematically. Predefined data were extracted and organized in a database. Quantity and quality were compared for three intervals of the study period comprising more than three decades. Evidence maps were constructed to identify gaps in evidence. Results: The search yielded 8210 results, of which 246 trials containing data on 26 154 patients were finally included. The number of RCTs per year increased continuously from a mean of 2·8, to 5·7 and up to 13·1 per year over the three intervals of the study. Most trials were conducted in Europe (46·3 per cent), followed by Asia (35·0 per cent) and North America (14·2 per cent). Overall, the quality of RCTs was moderate; however, with the exception of blinding, all domains of the Cochrane risk‐of‐bias tool improved significantly in the later part of the study. Evidence maps showed lack of evidence from RCTs for operations other than pancreatoduodenectomy and for specific diseases such as neuroendocrine neoplasms or intraductal papillary mucinous neoplasms. Conclusion: The quantity and quality of RCTs in pancreatic surgery have increased. Evidence mapping showed gaps for specific procedures and diseases, indicating priorities for future research. Trials are improving, gaps identified [ABSTRACT FROM AUTHOR]

Published
2019
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48. Pancreatogastrostomy Versus Pancreatojejunostomy for RECOnstruction After PANCreatoduodenectomy (RECOPANC, DRKS 00000767)

Author

Keck, Tobias, primary, Wellner, U. F., additional, Bahra, M., additional, Klein, F., additional, Sick, O., additional, Niedergethmann, M., additional, Wilhelm, T. J., additional, Farkas, S. A., additional, Börner, T., additional, Bruns, C., additional, Kleespies, A., additional, Kleeff, J., additional, Mihaljevic, A. L., additional, Uhl, W., additional, Chromik, A., additional, Fendrich, V., additional, Heeger, K., additional, Padberg, W., additional, Hecker, A., additional, Neumann, U. P., additional, Junge, K., additional, Kalff, J. C., additional, Glowka, T. R., additional, Werner, J., additional, Knebel, P., additional, Piso, P., additional, Mayr, M., additional, Izbicki, J., additional, Vashist, Y., additional, Bronsert, P., additional, Bruckner, T., additional, Limprecht, R., additional, Diener, M. K., additional, Rossion, I., additional, Wegener, I., additional, and Hopt, U. T., additional

Published
2016
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