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2. Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trialsResearch in context

Author

Ilias I. Siempos, Andre C. Kalil, Drifa Belhadi, Viviane Cordeiro Veiga, Alexandre Biasi Cavalcanti, Westyn Branch-Elliman, Eleni Papoutsi, Konstantinos Gkirgkiris, Nikoleta A. Xixi, Anastasia Kotanidou, Olivier Hermine, Raphaël Porcher, Xavier Mariette, Philippe Ravaud, Serge Bureau, Maxime Dougados, Matthieu Resche-Rigon, Pierre-Louis Tharaux, Annick Tibi, Elie Azoulay, Jacques Cadranel, Joseph Emmerich, Muriel Fartoukh, Bertrand Guidet, Marc Humbert, Karine Lacombe, Matthieu Mahevas, Frédéric Pene, Valerie Pourchet-Martinez, Frédéric Schlemmer, Yazdan Yazdanpanah, Gabriel Baron, Elodie Perrodeau, Damien Vanhoye, Cécile Kedzia, Lauren Demerville, Anne Gysembergh-Houal, Alexandre Bourgoin, Nabil Raked, Lakhdar Mameri, Claire Montlahuc, Lucie Biard, St.phanie Alary, Samir Hamiria, Thinhinane Bariz, Hala Semri, Dhiaa Meriem Hai, Moustafa Benafla, Mohamed Belloul, Pernelle Vauboin, Saskia Flamand, Claire Pacheco, Anouk Walter-Petrich, Emilia Stan, Souad Benarab, Corine Nyanou, Robin Charreteur, Céline Dupre, Kévin Cardet, Blandine Lehmann, Kamyl Baghli, Claire Madelaine, Eric D'Ortenzio, Oriane Puéchal, Caroline Semaille, Laurent Savale, Anatole Harrois, Samy Figueiredo, Jacques Duranteau, Nadia Anguel, Arthur Pavot, Xavier Monnet, Christian Richard, Jean-Louis Teboul, Philippe Durand, Pierre Tissieres, Mitja Jevnikar, David Montani, Stephan Pavy, Gaétane Nocturne, Samuel Bitoun, Nicolas Noel, Olivier Lambotte, Lelia Escaut, Stephane Jauréguiberry, Elodie Baudry, Christiane Verny, Edouard Lefevre, Mohamad Zaidan, Domitille Molinari, Gaël Leprun, Alain Fourreau, Laurent Cylly, Lamiae Grimaldi, Myriam Virlouvet, Ramdane Meftali, Soléne Fabre, Marion Licois, Asmaa Mamoune, Yacine Boudali, Clotilde Le Tiec, Céline Verstuyft, Anne-Marie Roques, Sophie Georgin-Lavialle, Patricia Senet, Gilles Pialoux, Angele Soria, Antoine Parrot, Helene François, Nathalie Rozensztajn, Emmanuelle Blin, Pascaline Choinier, Juliette Camuset, Jean-Simon Rech, Antony Canellas, Camille Rolland-Debord, Nadege Lemarié, Nicolas Belaube, Marine Nadal, Martin Siguier, Camille Petit-Hoang, Julie Chas, Elodie Drouet, Matthieu Lemoine, Audrey Phibel, Lucie Aunay, Eliane Bertrand, Sylviane Ravato, Marie Vayssettes, Anne Adda, Celine Wilpotte, Pélagie Thibaut, Julie Fillon, Isabelle Debrix, Soraya Fellahi, Jean-Philippe Bastard, Guillaume Lefévre, Jacques-Eric Gottenberg, Yves Hansmann, Frédéric Blanc, Sophie Ohlmann-Caillard, Vincent Castelain, Emmanuel Chatelus, Eva Chatron, Olivier Collange, François Danion, Frédéric De Blay, Pierre Diemunsch, Sophie Diemunsch, Renaud Felten, Bernard Goichot, Valentin Greigert, Aurelien Guffroy, Bob Heger, Charlotte Kaeuffer, Loic Kassegne, Anne Sophie Korganow, Pierrick Le Borgne, Nicolas Lefebvre, Paul-Michel Mertes, Eric Noll, Mathieu Oberlin, Vincent Poindron, Julien Pottecher, Yvon Ruch, François Weill, Nicolas Meyer, Emmanuel Andres, Eric Demonsant, Hakim Tayebi, Gabriel Nisand, Stéphane Brin, Cédric Sublon, Guillaume Becker, Anne Hutt, Tristan Martin, Sophie Bayer, Catherine Metzger, Arsene Mekinian, Noémie Abisror, Amir Adedjouma, Diane Bollens, Marion Bonneton, Nathalie Bourcicaux, Anne Bourrier, Maria Chauchard Thibault Chiarabiani, Doroth.e Chopin, Jonathan Cohen, Ines Devred, Bruno Donadille, Olivier Fain, Geoffrey Hariri, Vincent Jachiet, Patrick Ingliz, Marc Garnier, Marc Gatfosse, Etienne Ghrenassia, Delphine Gobert, Jessica Krause le Garrec, Cecilia Landman, Jean Remy Lavillegrand, Benedicte Lefebvre, Thibault Mahevas, Sandie Mazerand, Jean Luc Meynard, Marjolaine Morgand, Zineb Ouaz.ne, Jerome Pacanowski, S.bastien Riviere, Philippe Seksik, Harry Sokol, Heithem Soliman, Nadia Valin, Thomas Urbina, Chloé McAvoy, Maria Pereira Miranda, Gladys Aratus, Laurence Berard, Tabassome Simon, Anne Daguenel Nguyen, Elise Girault, Cl.mentine Mayala-Kanda, Marie Antignac, Céline Leplay, Jean-Benoit Arlet, Jean-Luc Diehl, Florence Bellenfant, Anne Blanchard, Alexandre Buffet, Bernard Cholley, Antoine Fayol, Edouard Flamarion, Anne Godier, Thomas Gorget, Sophie-Rym Hamada, Caroline Hauw-Berlemont, Jean-Sébastien Hulot, David Lebeaux, Marine Livrozet, Adrien Michon, Arthur Neuschwander, Marie-Aude Pennet, Benjamin Planquette, Brigitte Ranque, Olivier Sanchez, Geoffroy Volle, Sandrine Briois, Mathias Cornic, Virginie Elisee, Jesuthasan Denis, Juliette Djadi-Prat, Pauline Jouany, Ramon Junquera, Mickael Henriques, Amina Kebir, Isabelle Lehir, Jeanne Meunier, Florence Patin, Val.rie Paquet, Anne Tréhan, Véronique Vigna, Brigitte Sabatier, Damien Bergerot, Charléne Jouve, Camille Knosp, Olivia Lenoir, Nassim Mahtal, Léa Resmini, Xavier Lescure, Jade Ghosn, Antoine Bachelard, Anne Rachline, Valentina Isernia, Bao-chau, Phung, Dorothée Vallois, Aurelie Sautereau, Catherine Neukrich, Antoine Dossier, Raphaël Borie, Bruno Crestani, Gregory Ducrocq, Philippe Gabriel Steg, Philippe Dieude, Thomas Papo, Estelle Marcault, Marhaba Chaudhry, Charléne Da Silveira, Annabelle Metois, Ismahan Mahenni, Meriam Meziani, Cyndie Nilusmas, Sylvie Le Gac, Awa Ndiaye, Fran.oise Louni, Malikhone Chansombat, Zelie Julia, Solaya Chalal, Lynda Chalal, Laura Kramer, Jeniffer Le Grand, Kafif Ouifiya, Valentine Piquard, Sarah Tubiana, Yann Nguyen, Vasco Honsel, Emmanuel Weiss, Anais Codorniu, Virginie Zarrouk, Victoire de Lastours, Matthieu Uzzan, Naura Gamany, Agathe Claveirole, Alexandre Navid, Tiffanie Fouque, Yonathan Cohen, Maya Lupo, Constance Gilles, Roza Rahli, Zeina Louis, David Boutboul, Lionel Galicier, Yaël Amara, Gabrielle Archer, Amira Benattia, Anne Bergeron, Louise Bondeelle, Nathalie de Castro, Melissa Clément, Michaël Darmon, Blandine Denis, Clairelyne Dupin, Elsa Feredj, Delphine Feyeux, Adrien Joseph, Etienne Lenglin, Pierre Le Guen, Geoffroy Liégeon, Gwenaël Lorillon, Asma Mabrouki, Eric Mariotte, Grégoire Martin de Frémont, Adrien Mirouse, Jean-Michel Molina, Régis Peffault de Latour, Eric Oksenhendler, Julien Saussereau, Abdellatif Tazi, Jean-Jacques Tudesq, Lara Zafrani, Isabelle Brindele, Emmanuelle Bugnet, Karine Celli Lebras, Julien Chabert, Lamia Djaghout, Catherine Fauvaux, Anne Lise Jegu, Ewa Kozakiewicz, Martine Meunier, Marie-Thérèse Tremorin, Claire Davoine, Isabelle Madelaine, Sophie Caillat-Zucman, Constance Delaugerre, Florence Morin, Damien Sène, Ruxandra Burlacu, Benjamin Chousterman, Bruno Mégarbanne, Pascal Richette, Jean-Pierre Riveline, Aline Frazier, Eric Vicaut, Laure Berton, Tassadit Hadjam, Miguel Alejandro Vazquez-Ibarra, Clément Jourdaine, Olivia Tran, Véronique Jouis, Aude Jacob, Julie Smati, Stéphane Renaud, Claire Pernin, Lydia Suarez, Luca Semerano, Sébastien Abad, Ruben B. nainous, Nicolas Bonnet, Celine Comparon, Yves Cohen, Hugues Cordel, Robin Dhote, Nathalie Dournon, Boris Duchemann, Nathan Ebstein, Thomas Gille, Benedicte Giroux-Leprieur, Jeanne Goupil de Bouille, Hilario Nunes, Johanna Oziel, Dominique Roulot, Lucile Sese, ClaireTantet, Yurdagul Uzunhan, Coralie Bloch-Queyrat, Vincent Levy, Fadhila Messani, Mohammed Rahaoui, Myléne Petit, Sabrina Brahmi, Vanessa Rathoin, Marthe Rigal, Nathalie Costedoat-Chalumeau, Liem Binh Luong, Zakaria Ait Hamou, Sarah Benghanem, Philippe Blanche, Nicolas Carlier, Benjamin Chaigne, Remy Gauzit, Hassan Joumaa, Mathieu Jozwiak, Marie Lachétre, Hélène Lafoeste, Odie Launay, Paul Legendre, Jonathan Marey, Caroline Morbieu, Lola-Jade Palmieri, Tali-Anne Szwebel, Hendy Abdoul, Alexandra Bruneau, Audrey Beclin-Clabaux, Charly Larrieu, Pierre Montanari, Eric Dufour, Ada Clarke, Catherine Le Bourlout, Nathalie Marin, Nathalie Menage, Samira Saleh-Mghir, Mamadou Salif Cisse, Kahina Cheref, Corinne Guerin, Jérémie Zerbit, Marc Michel, Sébastien Gallien, Etienne Crickx, Benjamin Le Vavasseur, Emmanuelle Kempf, Karim Jaffal, William Vindrios, Julie Oniszczuk, Constance Guillaud, Pascal Lim, Elena Fois, Giovanna Melica, Marie Matignon, Maud Jalabert, Jean-Daniel Lelièvre, David Schmitz, Marion Bourhis, Sylia Belazouz, Laetitia Languille, Caroline Boucle, Nelly Cita, Agnés Didier, Fahem Froura, Katia Ledudal, Thiziri Sadaoui, Alaki Thiemele, Delphine Le Febvre De Bailly, Muriel Carvhalo Verlinde, Julien Mayaux, Patrice Cacoub, David Saadoun, Mathieu Vautier, Héléne Bugaut, Olivier Benveniste, Yves Allenbach, Gaëlle Leroux, Aude Rigolet, Perrine Guillaume-Jugnot, Fanny Domont, Anne Claire Desbois, Chloé Comarmond, Nicolas Champtiaux, Segolene Toquet, Amine Ghembaza, Matheus Vieira, Georgina Maalouf, Goncalo Boleto, Yasmina Ferfar, Jean-Christophe Corvol, C.line Louapre, Sara Sambin, Louise-Laure Mariani, Carine Karachi, Florence Tubach, Candice Estellat, Linda Gimeno, Karine Martin, Aicha Bah, Vixra Keo, Sabrine Ouamri, Yasmine Messaoudi, Nessima Yelles, Pierre Faye, Sebastien Cavelot, Cecile Larcheveque, Laurence Annonay, Jaouad Benhida, Aida Zahrate-Ghoul, Soumeya Hammal, Ridha Belilita, Fanny Charbonnier, Claire Aguilar, Fanny Alby-Laurent, Carole Burger, Clara Campos-Vega, Nathalie Chavarot, Benjamin Fournier, Claire Rouzaud, Damien Vimpére, Caroline Elie, Prissile Bakouboula, Laure Choupeaux, Sophie Granville, Elodie Issorat, Christine Broissand, Marie-Alexandra Alyanakian, Guillaume Geri, Nawal Derridj, Naima Sguiouar, Hakim Meddah, Mourad Djadel, Héléne Chambrin-Lauvray, Jean-Charles Duclos-vallée, Faouzi Saliba, Sophie-Caroline Sacleux, Ilias Kounis, Sonia Tamazirt, Eric Rudant, Jean-Marie Michot, Annabelle Stoclin, Emeline Colomba, Fanny Pommeret, Christophe Willekens, Rosa Da Silva, Valérie Dejean, Yasmina Mekid, Ines Ben-Mabrouk, Florence Netzer, Caroline Pradon, Laurence Drouard, Valérie Camara-Clayette, Alexandre Morel, Gilles Garcia, Abolfazl Mohebbi, Férial Berbour, Mélanie Dehais, Anne-Lise Pouliquen, Alison Klasen, Loren Soyez-Herkert, Jonathan London, Younes Keroumi, Emmanuelle Guillot, Guillaume Grailles, Younes El amine, Fanny Defrancq, Hanane Fodil, Chaouki Bouras, Dominique Dautel, Nicolas Gambier, Thierno Dieye, Boris Bienvenu, Victor Lancon, Laurence Lecomte, Kristina Beziriganyan, Belkacem Asselate, Laure Allanic, Elena Kiouris, Marie-Héléne Legros, Christine Lemagner, Pascal Martel, Vincent Provitolo, Félix Ackermann, Mathilde Le Marchand, Aurélie Chan Hew Wai, Dimitri Fremont, Elisabeth Coupez, Mireille Adda, Frédéric Duée, Lise Bernard, Antoine Gros, Estelle Henry, Claire Courtin, Anne Pattyn, Pierre-Grégoire Guinot, Marc Bardou, Agnes Maurer, Julie Jambon, Amélie Cransac, Corinne Pernot, Bruno Mourvillier, Eric Marquis, Philippe Benoit, Damien Roux, Coralie Gernez, Cécile Yelnik, Julien Poissy, Mandy Nizard, Fanette Denies, Helene Gros, Jean-Jacques Mourad, Emmanuelle Sacco, Sophie Renet, F. Ader, Y. Yazdanpanah, F. Mentre, N. Peiffer-Smadja, F.X. Lescure, J. Poissy, L. Bouadma, J.F. Timsit, B. Lina, F. Morfin-Sherpa, M. Bouscambert, A. Gaymard, G. Peytavin, L. Abel, J. Guedj, C. Andrejak, C. Burdet, C. Laouenan, D. Belhadi, A. Dupont, T. Alfaiate, B. Basli, A. Chair, S. Laribi, J. Level, M. Schneider, M.C. Tellier, A. Dechanet, D. Costagliola, B. Terrier, M. Ohana, S. Couffin-Cadiergues, H. Esperou, C. Delmas, J. Saillard, C. Fougerou, L. Moinot, L. Wittkop, C. Cagnot, S. Le Mestre, D. Lebrasseur-Longuet, V. Petrov-Sanchez, A. Diallo, N. Mercier, V. Icard, B. Leveau, S. Tubiana, B. Hamze, A. Gelley, M. Noret, E. D’Ortenzio, O. Puechal, C. Semaille, T. Welte, J.A. Paiva, M. Halanova, M.P. Kieny, E. Balssa, C. Birkle, S. Gibowski, E. Landry, A. Le Goff, L. Moachon, C. Moins, L. Wadouachi, C. Paul, A. Levier, D. Bougon, F. Djossou, L. Epelboin, J. Dellamonica, C.H. Marquette, C. Robert, S. Gibot, E. Senneville, V. Jean-Michel, Y. Zerbib, C. Chirouze, A. Boyer, C. Cazanave, D. Gruson, D. Malvy, P. Andreu, J.P. Quenot, N. Terzi, K. Faure, C. Chabartier, V. Le Moing, K. Klouche, T. Ferry, F, Valour, B. Gaborit, E. Canet, P. Le Turnier, D. Boutoille, F. Bani-Sadr, F. Benezit, M. Revest, C. Cameli, A. Caro, MJ Ngo Um Tegue, Y. Le Tulzo, B. Laviolle, F. Laine, G. Thiery, F. Meziani, Y. Hansmann, W. Oulehri, C. Tacquard, F. Vardon-Bounes, B. Riu-Poulenc, M. Murris-Espin, L. Bernard, D. Garot, O. Hinschberger, M. Martinot, C. Bruel, B. Pilmis, O. Bouchaud, P. Loubet, C. Roger, X. Monnet, S. Figueiredo, V. Godard, J.P. Mira, M. Lachatre, S. Kerneis, J. Aboab, N. Sayre, F. Crockett, D. Lebeaux, A. Buffet, J.L. Diehl, A. Fayol, J.S. Hulot, M. Livrozet, A Mekontso- Dessap, C. Ficko, F. Stefan, J. Le Pavec, J. Mayaux, H. Ait-Oufella, J.M. Molina, G. Pialoux, M. Fartoukh, J. Textoris, M. Brossard, A. Essat, E. Netzer, Y. Riault, M. Ghislain, L. Beniguel, M. Genin, L. Gouichiche, C. Betard, L. Belkhir, A. Altdorfer, V Fraipont Centro, S. Braz, JM Ferreira Ribeiro, R Roncon Alburqueque, M. Berna, M. Alexandre, B. Lamprecht, A. Egle, R. Greil, M. Joannidis, Thomas F. Patterson, Philip O. Ponce, Barbara S. Taylor, Jan E. Patterson, Jason E. Bowling, Heta Javeri, LuAnn Larson, Angela Hewlett, Aneesh K. Mehta, Nadine G. Rouphael, Youssef Saklawi, Nicholas Scanlon, Jessica J. Traenkner, Ronald P. Trible, Jr., Emmanuel B. Walter, Noel Ivey, Thomas L. Holland, Guillermo M. Ruiz-Palacios, Alfredo Ponce de León, Sandra Rajme, Lanny Hsieh, Alpesh N. Amin, Miki Watanabe, Helen S. Lee, Susan Kline, Joanne Billings, Brooke Noren, Hyun Kim, Tyler D. Bold, Victor Tapson, Jonathan Grein, Fayyaz Sutterwala, Nicole Iovine, Lars K. Beattie, Rebecca Murray Wakeman, Matthew Shaw, Mamta K. Jain, Satish Mocherla, Jessica Meisner, Amneris Luque, Daniel A. Sweeney, Constance A. Benson, Farhana Ali, Robert L. Atmar, Hana M. El Sahly, Jennifer Whitaker, Ann R. Falsey, Angela R. Branche, Cheryl Rozario, Justino Regalado Pineda, José Arturo Martinez-Orozco, David Chien Lye, Sean WX. Ong, Po Ying Chia, Barnaby E. Young, Uriel Sandkovsky, Mezgebe Berhe, Clinton Haley, Emma Dishner, Valeria D. Cantos, Colleen F. Kelley, Paulina A. Rebolledo Esteinou, Sheetal Kandiah, Sarah B. Doernberg, Pierre-Cedric B. Crouch, Hannah Jang, Anne F. Luetkemeyer, Jay Dwyer, Stuart H. Cohen, George R. Thompson, 3rd, Hien H. Nguyen, Robert W. Finberg, Jennifer P. Wang, Juan Perez-Velazquez, Mireya Wessolossky, Patrick E.H. Jackson, Taison D. Bell, Miranda J. West, Babafemi Taiwo, Karen Krueger, Johnny Perez, Triniece Pearson, Catharine I. Paules, Kathleen G. Julian, Danish Ahmad, Alexander G. Hajduczok, Henry Arguinchona, Christa Arguinchona, Nathaniel Erdmann, Paul Goepfert, Neera Ahuja, Maria G. Frank, David Wyles, Heather Young, Myoung-don Oh, Wan Beom Park, Chang Kyung Kang, Vincent Marconi, Abeer Moanna, Sushma Cribbs, Telisha Harrison, Eu Suk Kim, Jongtak Jung, Kyoung-Ho Song, Hong Bin Kim, Seow Yen Tan, Humaira Shafi, MF Jaime Chien, Raymond KC. Fong, Daniel D. Murray, Jens Lundgren, Henrik Nielsen, Tomas Jensen, Barry S. Zingman, Robert Grossberg, Paul F. Riska, Otto O. Yang, Jenny Ahn, Rubi Arias, Rekha R. Rapaka, Naomi Hauser, James D. Campbell, William R. Short, Pablo Tebas, Jillian T. Baron, Susan L.F. McLellan, Lucas S. Blanton, Justin B. Seashore, C. Buddy Creech, Todd W. Rice, Shannon Walker, Isaac P. Thomsen, Diego Lopez de Castilla, Jason W. Van Winkle, Francis X. Riedo, Surinder Kaur Pada, Alvin DY. Wang, Li Lin, Michelle Harkins, Gregory Mertz, Nestor Sosa, Louis Yi Ann Chai, Paul Anantharajah Tambyah, Sai Meng Tham, Sophia Archuleta, Gabriel Yan, David A. Lindholm, Ana Elizabeth Markelz, Katrin Mende, Richard Mularski, Elizabeth Hohmann, Mariam Torres-Soto, Nikolaus Jilg, Ryan C. Maves, Gregory C. Utz, Sarah L. George, Daniel F. Hoft, James D. Brien, Roger Paredes, Lourdes Mateu, Cora Loste, Princy Kumar, Sarah Thornton, Sharmila Mohanraj, Noreen A. Hynes, Lauren M. Sauer, Christopher J. Colombo, Christina Schofield, Rhonda E. Colombo, Susan E. Chambers, Richard M. Novak, Andrea Wendrow, Samir K. Gupta, Tida Lee, Tahaniyat Lalani, Mark Holodniy, Aarthi Chary, Nikhil Huprikar, Anuradha Ganesan, Norio Ohmagari, Ayako Mikami, D. Ashley Price, Christopher J.A. Duncan, Kerry Dierberg, Henry J. Neumann, Stephanie N. Taylor, Alisha Lacour, Najy Masri, Edwin Swiatlo, Kyle Widmer, James D. Neaton, Mary Bessesen, David S. Stephens, Timothy H. Burgess, Timothy M. Uyeki, Robert Walker, G. Lynn Marks, Anu Osinusi, Huyen Cao, Anabela Cardoso, Stephanie de Bono, Douglas E. Schlichting, Kevin K. Chung, Jennifer L. Ferreira, Michelle Green, Mat Makowski, Michael R. Wierzbicki, Tom M. Conrad, Jill Ann El-Khorazaty, Heather Hill, Tyler Bonnett, Nikki Gettinger, Theresa Engel, Teri Lewis, Jing Wang, John H. Beigel, Kay M. Tomashek, Varduhi Ghazaryan, Tatiana Beresnev, Seema Nayak, Lori E. Dodd, Walla Dempsey, Effie Nomicos, Marina Lee, Rhonda Pikaart-Tautges, Mohamed Elsafy, Robert Jurao, Hyung Koo, Michael Proschan, Tammy Yokum, Janice Arega, Ruth Florese, Jocelyn D. Voell, Richard Davey, Ruth C. Serrano, Zanthia Wiley, Varun K. Phadke, Paul A. Goepfert, Carlos A. Gomez, Theresa A. Sofarelli, Laura Certain, Hannah N. Imlay, Cameron R. Wolfe, Emily R. Ko, John J. Engemann, Nora Bautista Felix, Claire R. Wan, Sammy T. Elmor, Laurel R. Bristow, Michelle S. Harkins, Nicole M. Iovine, Marie-Carmelle Elie-Turenne, Victor F. Tapson, Pyoeng Gyun Choe, Richard A. Mularski, Kevin S. Rhie, Rezhan H. Hussein, Dilek Ince, Patricia L. Winokur, Jin Takasaki, Sho Saito, Kimberly McConnell, PharmD, David L. Wyles, Ellen Sarcone, Kevin A. Grimes, Katherine Perez, Charles Janak, Jennifer A. Whitaker, Paulina A. Rebolledo, John Gharbin, Allison A. Lambert, Diego F. Zea, Emma Bainbridge, David C. Hostler, Jordanna M. Hostler, Brian T. Shahan, Evelyn Ling, Minjoung Go, Fleesie A. Hubbard, Melony Chakrabarty, Maryrose Laguio-Vila, Edward E. Walsh, Faheem Guirgis, Vincent C. Marconi, Christian Madar, Scott A. Borgetti, Corri Levine, Joy Nock, Keith Candiotti, Julia Rozman, Fernando Dangond, Yann Hyvert, Andrea Seitzinger, Kaitlyn Cross, Stephanie Pettibone, Seema U. Nayak, and Gregory A. Deye

Subjects
Acute respiratory distress syndrome, Acute hypoxemic respiratory failure, Pneumonia, Critically ill, Cancer, Medicine (General), R5-920
Abstract

Summary: Background: Although immunomodulators have established benefit against the new coronavirus disease (COVID-19) in general, it is uncertain whether such agents improve outcomes without increasing the risk of secondary infections in the specific subgroup of previously immunocompromised patients. We assessed the effect of immunomodulators on outcomes of immunocompromised patients hospitalized for COVID-19. Methods: The protocol was prospectively registered with PROSPERO (CRD42022335397). MEDLINE, Cochrane Central Register of Controlled Trials and references of relevant articles were searched up to 01-06-2022. Authors of potentially eligible randomized controlled trials were contacted to provide data on immunocompromised patients randomized to immunomodulators vs control (i.e., placebo or standard-of-care). Findings: Eleven randomized controlled trials involving 397 immunocompromised patients hospitalized for COVID-19 were included. Ten trials had low risk of bias. There was no difference between immunocompromised patients randomized to immunomodulators vs control regarding mortality [30/182 (16.5%) vs 41/215 (19.1%); RR 0.93, 95% CI 0.61–1.41; p = 0.74], secondary infections (RR 1.00, 95% CI 0.64–1.58; p = 0.99) and change in World Health Organization ordinal scale from baseline to day 15 (weighed mean difference 0.27, 95% CI -0.09–0.63; p = 0.15). In subgroup analyses including only patients with hematologic malignancy, only trials with low risk of bias, only trials administering IL-6 inhibitors, or only trials administering immunosuppressants, there was no difference between comparators regarding mortality. Interpretation: Immunomodulators, compared to control, were not associated with harmful or beneficial outcomes, including mortality, secondary infections, and change in ordinal scale, when administered to immunocompromised patients hospitalized for COVID-19. Funding: Hellenic Foundation for Research and Innovation.

Published
2024
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3. Association of preoperative COVID-19 and postoperative respiratory morbidity during the Omicron epidemic wave: the DROMIS-22 multicentre prospective observational cohort studyResearch in context

Author

Marc Garnier, Jean-Michel Constantin, Raphaël Cinotti, Chafia Daoui, Dimitri Margetis, Grégory Destruhaut, Cédric Cirenei, Eric Noll, Christophe Quesnel, Agnes Lecinq, Sigismond Lasocki, Hélène Charbonneau, Stanislas Abrard, Cyril Quemeneur, Bruno Pastene, Nathanaël Lapidus, Marc Leone, El Mahdi Hafiani, Olivier Imauven, Emmanuel Rineau, Maxime Léger, Marc Danguy des Deserts, Johan Schmitt, Philippe Aries, Aurélie Gouel, Julia Voulgaropoulos, Laura Soldan, Romain Deransy, Quentin Laurent, Etienne Gayat, Franck Verdonk, Sabrina Chaouche, Amélie Cambriel, Vincent Degos, Julie Dupont, Laura Daoud, Romain Salettes, Malory Favreau, Julien Pottecher, Sophie Diemunsch, Cyril Bidon, Clémence Roy, Laëtitia Ottolenghi, Damien Edouard, Agnès Lecinq, Frédéric Mercier, Delphine Garrigue, Elsa Jozefowicz, Marie Pariès, Fabien Espitalier, Charlène Piat, Richard Descamps, Maëlle Duchesne, Stéphanie Sigaut, Laurie-Anne Thion, Julie Renard, Elsa Brocas, Besma Zbidi, Mohamed Fki, Guillaume Dufour, Mario Bucciero, Charles-Edouard Rochon, Céline Delerue, Virginie Trehel-Tursis, Julien Raft, Olivier Rangeard, Claire Thiriet, Kevin Lagarde, Angélina Pollet, Félix Pelen, Anaïs Caillard, Philippe Penven, Olivier Huet, Floriane Puel, Xavier Pichon, Laetitia Ligneres, Pauline Bleuze, Stéphanie Deryckere, Lionel Velly, Pierre Simeone, Hery Andrianjatovo, Youri Chipouline, Mouna Boolad, Denis Frasca, Quentin Plouviez, Benoit Plaud, Eric Roland, Delphine Cheron-Leroy, Samy Figueiredo, Antonia Blanié, Olivier Joannes-Boyau, Simon Monziols, Jean-Jacques Robin, Matthieu Biais, Hugues De Courson, Cécile Degryse, Marie Do-Khac, Marie-Pierre Bonnet, Aurélien Mazeraud, Jean Bardon, Eléonore Bouchereau, Karine Bezulier, Ségolène Mrozek, Nicolas Mayeur, and Sandrine Lopez

Subjects
COVID-19, Anaesthesia, Surgery, Perioperative risk, Respiratory complications, Postoperative pneumonia, Medicine (General), R5-920
Abstract

Summary: Background: Preoperative COVID-19 has been associated with excess postoperative morbi-mortality. Consequently, guidelines were developed that recommended the postponement of surgery for at least 7 weeks after the infection. We hypothesised that vaccination against the SARS-CoV-2 and the large predominance of the Omicron variant attenuated the effect of a preoperative COVID-19 on the occurrence of postoperative respiratory morbidity. Methods: We conducted a prospective cohort study in 41 French centres between 15 March and 30 May 2022 (ClinicalTrials NCT05336110), aimed at comparing the postoperative respiratory morbidity between patients with and without preoperative COVID-19 within 8 weeks prior to surgery. The primary outcome was a composite outcome combining the occurrence of pneumonia, acute respiratory failure, unexpected mechanical ventilation, and pulmonary embolism within the first 30 postoperative days. Secondary outcomes were 30-day mortality, hospital length-of-stay, readmissions, and non-respiratory infections. The sample size was determined to have 90% power to identify a doubling of the primary outcome rate. Adjusted analyses were performed using propensity score modelling and inverse probability weighting. Findings: Of the 4928 patients assessed for the primary outcome, of whom 92.4% were vaccinated against the SARS-CoV-2, 705 had preoperative COVID-19. The primary outcome was reported in 140 (2.8%) patients. An 8-week preoperative COVID-19 was not associated with increased postoperative respiratory morbidity (odds ratio 1.08 [95% CI 0.48–2.13]; p = 0.83). None of the secondary outcomes differed between the two groups. Sensitivity analyses concerning the timing between COVID-19 and surgery, and the clinical presentations of preoperative COVID-19 did not show any association with the primary outcome, except for COVID-19 patients with ongoing symptoms the day of surgery (OR 4.29 [1.02–15.8]; p = 0.04). Interpretation: In our Omicron-predominant, highly immunised population undergoing general surgery, a preoperative COVID-19 was not associated with increased postoperative respiratory morbidity. Funding: The study was fully funded by the French Society of Anaesthesiology and Intensive Care Medicine (SFAR).

Published
2023
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4. On the Strong Chromatic Index of Sparse Graphs

Author

DeOrsey, Philip, Diemunsch, Jennifer, Ferrara, Michael, Graber, Nathan, Hartke, Stephen G., Jahanbekam, Sogol, Lidicky, Bernard, Nelsen, Luke L., Stolee, Derrick, and Sullivan, Eric

Subjects
Mathematics - Combinatorics, 05C15
Abstract

The strong chromatic index of a graph $G$, denoted $\chi_s'(G)$, is the least number of colors needed to edge-color $G$ so that edges at distance at most two receive distinct colors. The strong list chromatic index, denoted $\chi_{s,\ell}'(G)$, is the least integer $k$ such that if arbitrary lists of size $k$ are assigned to each edge then $G$ can be edge-colored from those lists where edges at distance at most two receive distinct colors. We use the discharging method, the Combinatorial Nullstellensatz, and computation to show that if $G$ is a subcubic planar graph with $\operatorname{girth}(G) \geq 41$ then $\chi_{s,\ell}'(G) \leq 5$, answering a question of Borodin and Ivanova [Precise upper bound for the strong edge chromatic number of sparse planar graphs, Discuss. Math. Graph Theory, 33(4), (2014) 759--770]. We further show that if $G$ is a subcubic planar graph and $\operatorname{girth}(G) \geq 30$, then $\chi_s'(G) \leq 5$, improving a bound from the same paper. Finally, if $G$ is a planar graph with maximum degree at most four and $\operatorname{girth}(G) \geq 28$, then $\chi_s'(G) \leq 7$, improving a more general bound of Wang and Zhao from [Odd graphs and its application on the strong edge coloring, arXiv:1412.8358] in this case., Comment: 15 pages, 10 figures

Published
2015
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5. Color-blind index in graphs of very low degree

Author

Diemunsch, Jennifer, Graber, Nathan, Kramer, Lucas, Larsen, Victor, Nelsen, Lauren M., Nelsen, Luke L., Sigler, Devon, Stolee, Derrick, and Suer, Charlie

Subjects
Mathematics - Combinatorics, 05C15
Abstract

Let $c:E(G)\to [k]$ be an edge-coloring of a graph $G$, not necessarily proper. For each vertex $v$, let $\bar{c}(v)=(a_1,\ldots,a_k)$, where $a_i$ is the number of edges incident to $v$ with color $i$. Reorder $\bar{c}(v)$ for every $v$ in $G$ in nonincreasing order to obtain $c^*(v)$, the color-blind partition of $v$. When $c^*$ induces a proper vertex coloring, that is, $c^*(u)\neq c^*(v)$ for every edge $uv$ in $G$, we say that $c$ is color-blind distinguishing. The minimum $k$ for which there exists a color-blind distinguishing edge coloring $c:E(G)\to [k]$ is the color-blind index of $G$, denoted $\operatorname{dal}(G)$. We demonstrate that determining the color-blind index is more subtle than previously thought. In particular, determining if $\operatorname{dal}(G) \leq 2$ is NP-complete. We also connect the color-blind index of a regular bipartite graph to 2-colorable regular hypergraphs and characterize when $\operatorname{dal}(G)$ is finite for a class of 3-regular graphs., Comment: 10 pages, 3 figures, and a 4 page appendix

Published
2015
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6. Influence of intraoperative vasopressor use on indocyanine green fluorescence angiography: first evaluation in an experimental model

Author

Mahdi Al-Taher, Tim Pruimboom, Rutger M. Schols, Nariaki Okamoto, Nicole D. Bouvy, Laurents P. S. Stassen, René R. W. J. van der Hulst, Michael Kugler, Alexandre Hostettler, Eric Noll, Jacques Marescaux, Sophie Diemunsch, and Michele Diana

Subjects
Medicine, Science
Abstract

Abstract Intraoperative indocyanine green (ICG) fluorescence angiography has gained popularity and acceptance in many surgical fields for the real-time assessment of tissue perfusion. Although vasopressors have the potential to preclude an accurate assessment of tissue perfusion, there is a lack of literature with regards to its effect on ICG fluorescence angiography. An experimental porcine model was used to expose the small bowel for quantitative tissue perfusion assessment. Three increasing doses of norepinephrine infusion (0.1, 0.5, and 1.0 µg/kg/min) were administered intravenously over a 25-min interval. Time-to-peak fluorescence intensity (TTP) was the primary outcome. Secondary outcomes included absolute fluorescence intensity and local capillary lactate (LCL) levels. Five large pigs (mean weight: 40.3 ± 4.24 kg) were included. There was no significant difference in mean TTP (in seconds) at baseline (4.23) as compared to the second (3.90), third (4.41), fourth (4.60), and fifth ICG assessment (5.99). As a result of ICG accumulation, the mean and the maximum absolute fluorescence intensity were significantly different as compared to the baseline assessment. There was no significant difference in LCL levels (in mmol/L) at baseline (0.74) as compared to the second (0.82), third (0.64), fourth (0.60), and fifth assessment (0.62). Increasing doses of norepinephrine infusion have no significant influence on bowel perfusion using ICG fluorescence angiography.

Published
2021
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7. Protocol for TRAUMADORNASE: a prospective, randomized, multicentre, double-blinded, placebo-controlled clinical trial of aerosolized dornase alfa to reduce the incidence of moderate-to-severe hypoxaemia in ventilated trauma patients

Author

Julien Pottecher, Eric Noll, Marie Borel, Gérard Audibert, Sébastien Gette, Christian Meyer, Elisabeth Gaertner, Vincent Legros, Raphaël Carapito, Béatrice Uring-Lambert, Erik Sauleau, Walter G. Land, Seiamak Bahram, Alain Meyer, Bernard Geny, and Pierre Diemunsch

Subjects
Acute respiratory distress syndrome, Adult, Hypoxaemia, Multiple trauma, Deoxyribonuclease I, Neutrophil extracellular traps, Medicine (General), R5-920
Abstract

Abstract Background Acute respiratory distress syndrome continues to drive significant morbidity and mortality after severe trauma. The incidence of trauma-induced, moderate-to-severe hypoxaemia, according to the Berlin definition, could be as high as 45%. Its pathophysiology includes the release of damage-associated molecular patterns (DAMPs), which propagate tissue injuries by triggering neutrophil extracellular traps (NETs). NETs include a DNA backbone coated with cytoplasmic proteins, which drive pulmonary cytotoxic effects. The structure of NETs and many DAMPs includes double-stranded DNA, which prevents their neutralization by plasma. Dornase alfa is a US Food and Drug Administration-approved recombinant DNase, which cleaves extracellular DNA and may therefore break up the backbone of NETs and DAMPs. Aerosolized dornase alfa was shown to reduce trauma-induced lung injury in experimental models and to improve arterial oxygenation in ventilated patients. Methods TRAUMADORNASE will be an institution-led, multicentre, double-blinded, placebo-controlled randomized trial in ventilated trauma patients. The primary trial objective is to demonstrate a reduction in the incidence of moderate-to-severe hypoxaemia in severe trauma patients during the first 7 days from 45% to 30% by providing aerosolized dornase alfa as compared to placebo. The secondary objectives are to demonstrate an improvement in lung function and a reduction in morbidity and mortality. Randomization of 250 patients per treatment arm will be carried out through a secure, web-based system. Statistical analyses will include a descriptive step and an inferential step using fully Bayesian techniques. The study was approved by both the Agence Nationale de la Sécurité du Médicament et des Produits de Santé (ANSM, on 5 October 2018) and a National Institutional Review Board (CPP, on 6 November 2018). Participant recruitment began in March 2019. Results will be published in international peer-reviewed medical journals. Discussion If early administration of inhaled dornase alfa actually reduces the incidence of moderate-to-severe hypoxaemia in patients with severe trauma, this new therapeutic strategy may be easily implemented in many clinical trauma care settings. This treatment may facilitate ventilator weaning, reduce the burden of trauma-induced lung inflammation and facilitate recovery and rehabilitation in severe trauma patients. Trial registration ClinicalTrials.gov, NCT03368092 . Registered on 11 December 2017.

Published
2020
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8. Metabolomic Impact of Lidocaine on a Triple Negative Breast Cancer Cell Line

Author

Thiên-Nga Chamaraux-Tran, Marie Muller, Julien Pottecher, Pierre A. Diemunsch, Catherine Tomasetto, Izzie-Jacques Namer, and Nassim Dali-Youcef

Subjects
lidocaine, onco-anesthesia, perioperative period, anesthesia, cancer surgery, metabolomics, Therapeutics. Pharmacology, RM1-950
Abstract

Background: Metabolomics and onco-anesthesia are two emerging research fields in oncology. Metabolomics (metabolites analysis) is a new diagnostic and prognostic tool that can also be used for predicting the therapeutic or toxic responses to anticancer treatments. Onco-anesthesia studies assess the impact of anesthesia on disease-free and overall survival after cancer surgery. It has been shown that local anesthetics (LA), particularly lidocaine (LIDO), exert antitumor properties both in vitro and in vivo and may alter the biologic fingerprints of cancer cells. As LA are known to impair mitochondrial bioenergetics and byproducts, the aim of the present study was to assess the impact of LIDO on metabolomic profile of a breast cancer cell line.Methods: Breast cancer MDA-MB-231 cells were exposed for 4 h to 0.5 mM LIDO or vehicle (n = 4). The metabolomic fingerprint was characterized by high resolution magic angle spinning NMR spectroscopy (HRMAS). The multivariate technique using the Algorithm to Determine Expected Metabolite Level Alteration (ADEMA) (Cicek et al., PLoS Comput. Biol., 2013, 9, e1002859), based on mutual information to identify expected metabolite level changes with respect to a specific condition, was used to determine the metabolites variations caused by LIDO.Results: LIDO modulates cell metabolites levels. Several pathways, including glutaminolysis, choline, phosphocholine and total choline syntheses were significantly downregulated in the LIDO group.Discussion: This is the first study assessing the impact of LIDO on metabolomic fingerprint of breast cancer cells. Among pathways downregulated by LIDO, many metabolites are reported to be associated with adverse prognosis when present at a high titer in breast cancer patients. These results fit with the antitumor properties of LIDO and suggest its impact on metabolomics profile of cancer cells. These effects of LIDO are of clinical significance because it is widely used for local anesthesia with cutaneous infiltration during percutaneous tumor biopsy. Future in vitro and preclinical studies are necessary to assess whether metabolomics analysis requires modification of local anesthetic techniques during tumor biopsy.

Published
2022
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11. Prévention de l’hypotension survenant pendant une rachianesthésie

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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12. Déambulation sous-péridurale au cours du travail

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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13. Recommandations pour l’anesthésie-analgésie obstétricale chez une patiente mineure

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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14. Maladie thromboembolique veineuse

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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15. Urapidil

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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16. Place de l’hypnose médicale en secteur de naissance

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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17. Prophylaxie de l’endocardite infectieuse

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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18. Femme enceinte consommatrice de substances psycho-actives

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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19. Intérêt du ballon de Bakri

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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20. Maladie de Willebrand : conduite à tenir pour l’accouchement

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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21. Diagnostic clinique et biologique et prise en charge en cas de suspicion d’embolie amniotique

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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22. Conditions préalables et indications de l’analgésie péridurale

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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23. Péri-rachianesthésie combinée en obstétrique

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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24. Céphalées post-brèche duremérienne

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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25. Conduite à tenir en cas de déconnexion accidentelle d’un cathéter de péridurale

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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26. Prise en charge de l’anémie gravido-puerpérale

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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27. Choc anaphylactique pendant la grossesse

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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28. Anesthésie pour extraction instrumentale

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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29. Péridurale et utérus cicatriciel

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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30. Anesthésie pour grossesse multiple

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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31. Protocole d’Intralipide® en cas d’arrêt cardiaque dû à un anesthésique local

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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32. Prééclampsie et éclampsie

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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33. Prévention des nausées et vomissements postopératoires

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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34. Transversus abdominis plane block et césarienne

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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35. PIEB : programmed intermittent epidural bolus

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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36. ECMO (assistance extracorporelle)

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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37. Contre-indications de l’anesthésie péridurale

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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38. Le PRES ou posterior reversible encephalopathy syndrome, en obstétrique

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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39. Quadratus lomborum block

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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40. Salle de surveillance postinterventionnelle en obstétrique

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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41. Recherche d’agglutinines irrégulières (RAI)

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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42. Éléments de langage en cas de situation critique en anesthésie obstétricale

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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43. Transfusion incompatible pour groupes/ACI rares

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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44. Arrêt cardiaque chez la femme enceinte

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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45. Analgésie périnéale en post-partum de l’accouchement voie basse

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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46. Imagerie des blocs de paroi

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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47. Extension de péridurale pour césarienne en cours de travail

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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48. Bilan annuel des complications dégénératives de la drépanocytose

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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49. Antivitamines K et allaitement

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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50. Obésité morbide : grossesse et accouchement

Author

Aya, G., primary, Benhamou, D., additional, Bonnet, M.-P., additional, Bonnin, M., additional, Bouvet, L., additional, Bruyère, M., additional, Castel, A., additional, Chassard, D., additional, Dewandre, P.-Y., additional, Diemunsch, P., additional, Ducloy-Bouthors, A.-S., additional, Fischer, C., additional, Fournet-Fayard, A., additional, Fuzier, V., additional, Julliac, B., additional, Keita, H., additional, Lopard, E., additional, Mercier, F., additional, Moreau, E., additional, Nebout, S., additional, Roger-Christoph, S., additional, Ruivard, M., additional, Storme, B., additional, and Vial, F., additional

Published
2021
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