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3. Investigation of spaceborne trace gas products over St Petersburg and Yekaterinburg, Russia, by using COllaborative Column Carbon Observing Network (COCCON) observations

Author

Alberti, C., Tu, Q., Hase, F., Makarova, M. V., Gribanov, K., Foka, S. C., Zakharov, V., Blumenstock, T., Buchwitz, M., Diekmann, C., Ertl, B., Frey, M. M., Imhasin, H. K., Ionov, D. V., Khosrawi, F., Osipov, S. I., Reuter, M., Schneider, M., Warneke, T., Alberti, C., Tu, Q., Hase, F., Makarova, M. V., Gribanov, K., Foka, S. C., Zakharov, V., Blumenstock, T., Buchwitz, M., Diekmann, C., Ertl, B., Frey, M. M., Imhasin, H. K., Ionov, D. V., Khosrawi, F., Osipov, S. I., Reuter, M., Schneider, M., and Warneke, T.

Abstract

This work employs ground- and space-based observations, together with model data, to study columnar abundances of atmospheric trace gases (XH2O, XCO2, XCH4 and XCO) in two high-latitude Russian cities, St. Petersburg and Yekaterinburg. Two portable COllaborative Column Carbon Observing Network (COCCON) spectrometers were used for continuous measurements at these locations during 2019 and 2020. Additionally, a subset of data of special interest (a strong gradient in XCH4 and XCO was detected) collected in the framework of a mobile city campaign performed in 2019 using both instruments is investigated. All studied satellite products (TROPOMI, OCO-2, GOSAT, MUSICA IASI) show generally good agreement with COCCON observations. Satellite and ground-based observations at high latitudes are much sparser than at low or mid latitudes, which makes direct coincident comparisons between remote-sensing observations more difficult. Therefore, a method of scaling continuous Copernicus Atmosphere Monitoring Service (CAMS) model data to the ground-based observations is developed and used for creating virtual COCCON observations. These adjusted CAMS data are then used for satellite validation, showing good agreement in both Peterhof and Yekaterinburg. The gradients between the two study sites ( "Xgas) are similar between CAMS and CAMS-COCCON datasets, indicating that the model gradients are in agreement with the gradients observed by COCCON. This is further supported by a few simultaneous COCCON and satellite "Xgas measurements, which also agree with the model gradient. With respect to the city campaign observations recorded in St Petersburg, the downwind COCCON station measured obvious enhancements for both XCH4 (10.6ĝ€¯ppb) and XCO (9.5ĝ€¯ppb), which is nicely reflected by TROPOMI observations, which detect city-scale gradients of the order 9.4ĝ€¯ppb for XCH4 and 12.5ĝ€¯ppb for XCO. Copyright: © 2022 Carlos Alberti et al.

Published
2022

4. Verwendung von Prüfkörpern zur Überprüfung der Reinigungsleistung bei der Validierung von Reinigungs-Desinfektions-Prozessen.

Author

Appel, T., Bungardt, S., Diekmann, C., Fažon, M., Forster, A., Hartwig, A., Hunold, M., Igla, M., Jones, A., Kirmse, G., Mann, K., Metzing, J., Pohl, M., Regnieth, G., Schricker, D., van Waveren, A., and Zimmermann, U.

Subjects
SURGICAL instruments, EQUIPMENT & supplies, CLEANING compounds, QUALITY control, QUALITY assurance, STERILIZATION (Disinfection), MANAGEMENT
Published
2023

5. Quantification of CH4 emissions from waste disposal sites near the city of Madrid using ground- and space-based observations of COCCON, TROPOMI and IASI

Author

Tu, Q., Hase, F., Schneider, M., Garciá, O., Blumenstock, T., Borsdorff, T., Frey, M., Khosrawi, F., Lorente, A., Alberti, C., Bustos, J. J., Butz, A., Carreño, V., Cuevas, E., Curcoll, R., Diekmann, C. J., Dubravica, D., Ertl, B., Estruch, C., León-Luis, S. F., Marrero, C., Morgui, J.-A., Ramos, R., Scharun, C., Schneider, C., Sepúlveda, E., Toledano, C., and Torres, C.

Subjects
reenhouse gases emissions, Earth sciences, TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES, Infrared Atmospheric Sounding Interferometer, ddc:550, Tropospheric Monitoring Instrument, Carbon Column Observing Network, Remote sensing, Methane, Greenhouse gases emissions
Abstract

The objective of this study is to derive methane (CH4) emissions from three landfills, which are found to be the most significant CH4 sources in the metropolitan area of Madrid in Spain. We derive CH4 emissions from the CH4 enhancements observed by spaceborne and ground-based instruments. We apply satellite-based measurements from the TROPOspheric Monitoring Instrument (TROPOMI) and the Infrared Atmospheric Sounding Interferometer (IASI) together with measurements from the ground-based COllaborative Carbon Column Observing Network (COCCON) instruments. In 2018, a 2-week field campaign for measuring the atmospheric concentrations of greenhouse gases was performed in Madrid in the framework of Monitoring of the Greenhouse Gases Concentrations in Madrid (MEGEI-MAD) project. Five COCCON instruments were deployed at different locations around the Madrid city center, enabling the observation of total column-averaged CH4 mixing ratios (XCH4). Considering the prevalent wind regimes, we calculate the wind-assigned XCH4 anomalies for two opposite wind directions. Pronounced bipolar plumes are found when applying the method to NO2, which implies that our method of wind-assigned anomaly is suitable to estimate enhancements of trace gases at the urban level from satellite-based measurements. For quantifying the CH4 emissions, the wind-assigned plume method is applied to the TROPOMI XCH4 and to the lower tropospheric CH4 / dry-air column ratio (TXCH4) of the combined TROPOMI+IASI product. As CH4 emission strength we estimate 7.4 × 1025 ± 6.4 × 1024 molec. s−1 from the TROPOMI XCH4 data and 7.1 × 1025 ± 1.0 × 1025 molec. s−1 from the TROPOMI+IASI merged TXCH4 data. We use COCCON observations to estimate the local source strength as an independent method. COCCON observations indicate a weaker CH4 emission strength of 3.7 × 1025 molec. s−1 from a local source (the Valdemingómez waste plant) based on observations from a single day. This strength is lower than the one derived from the satellite observations, and it is a plausible result. This is because the analysis of the satellite data refers to a larger area, covering further emission sources in the study region, whereas the signal observed by COCCON is generated by a nearby local source. All emission rates estimated from the different observations are significantly larger than the emission rates provided via the official Spanish Register of Emissions and Pollutant Sources.

Published
2021

6. Reinigung und Desinfektion von Sterilisationscontainern sowie Transport- und Lagerungsbehältern für desinfizierte und sterilisierte sowie kontaminierte Medizinprodukte.

Author

Appel, T., Betz, D., Bungardt, S., Deinet, F., Diedrich, D., Diekmann, C., Fažon, M., Forster, A., Graßhoff, C., Hartwig, A., Hückinghaus, H., Jäkel, C., Jones, A., Kirmse, G., Mann, K., Metzing, J., Pozo, H., Regnieth, G., Sauer, P., and Schmid, C.

Subjects
STERILIZATION equipment, EQUIPMENT & supplies, MEDICAL equipment contamination, RISK assessment, MEDICAL equipment safety measures, AUTOMATION, STERILIZATION (Disinfection), MEDICAL equipment reuse, TRANSPORTATION, PREVENTION
Published
2022

7. Correction:High-risk additional chromosomal abnormalities at low blast counts herald death by CML (Leukemia, (2020), 34, 8, (2074-2086), 10.1038/s41375-020-0826-9)

Author

Hehlmann, Rüdiger, Voskanyan, Astghik, Lauseker, Michael, Pfirrmann, Markus, Kalmanti, Lida, Rinaldetti, Sebastien, Kohlbrenner, Katharina, Haferlach, Claudia, Schlegelberger, Brigitte, Fabarius, Alice, Seifarth, Wolfgang, Spieß, Birgit, Wuchter, Patrick, Krause, Stefan, Kolb, Hans Jochem, Neubauer, Andreas, Hossfeld, Dieter K., Nerl, Christoph, Gratwohl, Alois, Baerlocher, Gabriela M., Burchert, Andreas, Brümmendorf, Tim H., Hasford, Jörg, Hochhaus, Andreas, Saußele, Susanne, Baccarani, Michele, von Weikersthal, L. Fischer, Hahn, M., Schlimok, G., Reichert, D., Janssen, J., Martens, U., Majunke, P., Reichert, Peter, Neben, K., Korsten, S., Scholz, Ch, Oldenkott, B., Heßling, J., Kingreen, D., Sperling, C., Schelenz, C., Blau, I., Urmersbach, A., Ludwig, W., Le Coutre, P., Arnold, R., de Wit, M., Pezzutto, A., Schäfer, E., Schroers, R., Lochter, A., Behringer, D., Ko, Y., Weidenhöfer, S., Verbeek, W., Brossart, P., Trenn, G., Pommerien, W., Krauter, J., Doering, G., Munzinger, H., Diekmann, C., Hertenstein, B., Stier, S., Möller-Faßbender, F., Hänel, M., Zöller, T., Lamberti, C., Koch, B., Henzel, A., Wagner, S., Schmalenbach, A., Hoffknecht, M., Ehninger, G., Kiani, A., Illmer, T., Aul, C., Flaßhove, M., Henneke, F., Simon, M., Müller, L., Becker, H., Janz, R., Eckart, M. J., Fuchs, R., Schlegel, F., Wattad, M., Rudolph, R., Beelen, D. W., Lindemann, A., Linck, D., Wassman, Jäger, E., Al-Batran, S., Reiber, T., Waller, C. F., Hoeffkes, H., Schulz, L., Tajrobehkar, K., Mittermüller, J., Pralle, H., Runde, V., Hoyer, A., Tessen, H., Trümper, L., Schmidt, C., Sieber, M., Eschenburg, H., Depenbusch, R., Rösel, S., Lindemann, H. W., Wolf, H., Spohn, C., Moeller, R., Hossfeld, D., Zander, A., Schafhausen, P., Köster, H., Hollburg, W., Schmitz, N., Dürk, H., Hemeier, M., Grote-Metke, A., Weischer, H., Bechtel, B., Balleisen, L., Sosada, M., Ho, A., Petersen, V., Dengler, J., Bildat, S., Hahn, L., Dietzfelbinger, H., Gröschel, W., Bartholomäus, A., Freier, W., Sievers, B., Pfreundschuh, I. M., Herrmann, T., Fauser, A., Menzel, J., Kemmerling, M., Hansen, R., Link, H., Schatz, M., Bentz, M., Prümmer, O., Kneba, M., Heymanns, J., Schmitz, S., Scheid, C., Lollert, A., Neise, M., Planker, M., Stauch, M., Schröder, M., Kempf, B., Vehling-Kaiser, U., Kremers, S., Köchling, G., Hartmann, F., Neuhaus, T., Fetscher, S., Kämpfe, D., Heil, G., Uppenkamp, M., Goldmann, B., Huber, T. Fischer, Hieber, U., Plöger, C., Griesshammer, M., Lange, C., Göttler, B., Lunscken, C., Schiel, X., Scheidegger, C., Stötzer, O., Hitz, H., Schick, H., Völkl, S., Spiekermann, K., Berdel, W., Hebart, H., Ladda, E., Schmidt, P., Burkhardt, U., Hentschke, S., Falge, C., Reschke, D., Köhne, C. A., Müller-Naendrup, C., Sauer, M., Frühauf, S., Ranft, K., Dencausse, Y., Sandritter, B., Baake, G., Hofknecht, M., Dengler, R., Edinger, M., Schenk, M., Wehmeier, A., Weidelich, H. P., Pihusch, R., Stahlhut, K., Baldus, M., Matzdorff, A., Geer, T., Schanz, S., Käfer, G., Gassmann, W., Priebe-Richter, C., Demandt, M., Springer, G., Fiechtner, H., Denzlinger, C., Schleicher, J., Assman, D., Gaeckler, R., Adam, G., Waladkhani, A., Rendenbach, B., Forstbauer, H., Kanz, L., Jacki, S., Stegelmann, F., Kalhori, N., Nusch, A., Langer, W., Müller, F., Brettner, S., Uebelmesser, B., Kamp, T., Schadeck-Gressel, C., Josten, K., Klein, O., Schwerdtfeger, R., Baurmann, H., Strotkötter, H., Fett, W., Raghavachar, A., Maintz, C., Goebler, M. C., Schlag, R., Elsel, W., Wernli, M., Heim, D., Wuillemin, W., Hess, U., Gmür, J., and Mayer, J.

Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020

8. Monitorización de las concentraciones atmosféricas de metano y óxido nitroso a partir del Metop/IASI

Author

European Commission, Ministerio de Economía y Competitividad, García, O., Schneider, M., Ertl, B., Sepúlveda, E., Borger, C., Diekmann, C., Hase, F., Khosrawi, F., Cansado, A., Aullé, M., European Commission, Ministerio de Economía y Competitividad, García, O., Schneider, M., Ertl, B., Sepúlveda, E., Borger, C., Diekmann, C., Hase, F., Khosrawi, F., Cansado, A., and Aullé, M.

Abstract

[EN] Future of the Earth-atmosphere system will depend, to a large extent, on our capability of understanding all the processes driving climate change and, in this context, of outstanding importance are the monitoring and the investigation of greenhouse gases (GHGs), as main drivers of the Earth’s climate change. With this idea the project INMENSE (IASI for Surveying Methane and Nitrous Oxide in the Troposphere) was born, which aims to improve our current understanding of the atmospheric budgets of two of the most important well-mixed greenhouse gases, methane (CH4) and nitrous oxide (N2O). To this end, INMENSE has generated a new global observational data set of middle/upper tropospheric concentrations of CH4 and N2O from the space-based remote sensor IASI (Infrared Atmospheric Sounding Interferometer), on board the meteorological satellites EUMETSAT/Metop. In this work the INMENSE IASI CH4 and N2O products are presented, characterized and comprehensively validated by using a multiplatform reference database (aircraft vertical profiles, ground-based in-situ and remote-sensing observations). This extensive validation exercise suggests that the IASI CH4 and N2O products shows a precision between 1-3% and a bias of 2% as well as they are consistent temporally and spatially. Finally, the CH4 and N2O IASI observations over the Iberian Peninsula have been compared to MOCAGE chemical transport simulations, assessing the degree of agreement between both datasets., [ES] El futuro del sistema Tierra-atmósfera dependerá, en gran medida, de nuestra capacidad para entender todos los procesos que están conduciendo al calentamiento global, y sus consecuencias climáticas, y, en este contexto, los gases de efecto invernadero (GEIs) juegan un papel clave como uno de los principales motores del cambio climático. Con esta idea nace el proyecto de investigación INMENSE (IASI for Surveying Methane and Nitrous Oxide in the Troposphere), el cual tiene como objetivo mejorar nuestra compresión de los balances atmosféricos de dos de los más importantes GEIs, el metano (CH4) y el óxido nitroso (N2O). Para ello, el proyecto INMENSE ha generado nuevas observaciones de concentraciones de CH4 y N2O en la troposfera media/alta a escala global a partir de las medidas satelitales del sensor IASI (Infrared Atmospheric Sounding Interferometer), que vuela a bordo de los satélites meteorológicos EUMETSAT/Metop. En este trabajo los productos INMENSE IASI de CH4 y N2O son presentados, caracterizados y extensamente validados usando una base de datos de referencia multiplataforma (perfiles verticales de avión, medidas in-situ y remotas desde superficie). Esta completa validación sugiere que los productos IASI de CH4 y N2O tienen una precisión entre el 1-3% y un error sistemático del 2%, así como que son consistentes temporal y espacialmente. Por último, las observaciones IASI de CH4 y N2O sobre la Península Ibérica han sido comparadas a las simulaciones del modelo de transporte químico MOCAGE, analizando el grado de acuerdo entre ambas bases de datos.

Published
2020

13. Hygiene im OP

Author

Diekmann, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Heutige Hygiene im ophthalmochirugischen OP Hygiene im OP erfordert höchste Disziplin aller ärztlicher und nichtärztlicher Mitarbeiter. Bereits bei der Umsetzung der Basishygiene schleichen sich immer wieder Fehler ein oder Maßnahmen werden nicht an die rechtlichen Anforderungen[zum vollständigen Text gelangen Sie über die oben angegebene URL], 30. Internationaler Kongress der Deutschen Ophthalmochirurgen

Published
2017
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14. Hygiene aspects when dealing with external persons in the RUMED.

Author

Alflen, M., Amman, B., Appel, T., Carter, A., Deinet, F., Diedrich, D., Diekmann, C., Fengler, T., Gehrmann, K., Hartwig, A., Grabhoff, C., Graf, J., Hartel, M., Jones, A., Kirmse, G., Kruger, S., Mann, K., Mock, I., Roitsch, M., and van Waveren, A.

Subjects
MEDICAL equipment safety measures, INDUSTRIAL hygiene, QUALITY control, OCCUPATIONAL hazards, MEDICAL equipment industry
Abstract

The article highlights the recommendations of Germany's Quality Task Force for maintaining hygiene standards when dealing with external persons in the Reprocessing Unit for Medical Devices (RUMED). Topics discussed include health risks facing external persons in the RUMED, hazard assessment as per the Biological Agents Regulation, and mandatory protective measures for external persons.

Published
2020

15. Hygienische Aspekte beim Umgang mit externen Personen in der AEMP.

Author

Alflen, M., Amman, B., Appel, T., Carter, A., Deinet, F., Diedrich, D., Diekmann, C., Fengler, T., Gehrmann, K., Hartwig, A., Grabhoff, C., Graf, J., Hartel, M., Jones, A., Kirmse, G., Kruger, S., Mann, K., Mock, I., Roistch, M., and van Waveren, A.

Published
2020

16. Transport between the site of use and reprocessing department.

Author

Alflen, M., Amann, B., Appel, T., Diedrich, D., Diekmann, C., Fengler, T., Gehrmann, K., Gerasch, T., Hartwig, A., Mann, K., Metzing, J., Otzmann, R., Papadopoulos, A., van Waveren, A., Wiese, K., and Zimmermann, U.

Subjects
TRANSPORTATION, STORAGE, MEDICAL equipment, CONTAMINATION equipment, ECOLOGY
Abstract

The article presents the transport and storage not adversely affecting the medical device characteristics. Topics include sterilized medical devices (MDs) being protected against contamination when transported between the reprocessing department and the site of use; using MDs harbor potentially infectious contaminants against which the must be protected; and sterilized MDs must be transported separately from non-sterilized MDs in ruling out contamination.

Published
2020

17. Transporte zwischen Anwendungs- und Aufbereitungsort.

Author

Alflen, M., Amann, B., Appel, T., Diedrich, D., Diekmann, C., Fengler, T., Gehrmann, K., Gerasch, T., Hartwig, A., Mann, K., Metzing, J., Otzmann, R., Papadopoulos, A., van Waveren, A., Wiese, K., and Zimmermann, U.

Published
2020

18. Comparison of 18F-GE-180 and dynamic 18F-FET PET in high grade glioma: a double-tracer pilot study

Author

Unterrainer, Marcus, primary, Fleischmann, D. F., additional, Diekmann, C., additional, Vomacka, L., additional, Lindner, S., additional, Vettermann, F., additional, Brendel, M., additional, Wenter, V., additional, Ertl-Wagner, B., additional, Herms, J., additional, Wetzel, C., additional, Rupprecht, R., additional, Tonn, J. C., additional, Belka, C., additional, Bartenstein, P., additional, Niyazi, M., additional, and Albert, Nathalie L., additional

Published
2018
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21. Limited clinical relevance of imaging techniques in the follow-up of patients with advanced chronic lymphocytic leukemia: results of a meta-analysis

Author

Eichhorst, Barbara F, Fischer, Kirsten, Fink, Anna Maria, Elter, Thomas, Wendtner, Clemens M, Goede, Valentin, Bergmann, Manuela, Stilgenbauer, Stephan, Hopfinger, Georg, Ritgen, Matthias, Bahlo, Jasmin, Busch, Raymonde, Hallek, Michael, Oduncu, F, Dreyling, M, Forstpointner, R, Schneller, F, Bogner, C, Peschel, C, Ringshausen, I, Götze, K, Goebeler, Me, Rückle, Lanz, Ritgen, M, Schawitzke, A, Heydrich, B, Kern, K, Böttcher, S, Irmer, S, Strack, U, Borries, V, Klima, Km, Scholz, C, Herold, M, Härtwig, K, Dürig, J, Dührsen, U, Müller Beissenhirtz, H, Noppeney, R, Schüttrumpf, S, Hohloch, K, Binder, C, Hasenkamp, J, Trümper, L, Bäsecke, J, Rieger, M, Witzens Harig, M, Friedrichs, B, Rieger, K, Uharek, L, Kubuschok, B, Murawski, N, Held, G, Zwick, C, Pfreundschuh, M, Fingerle Rowson, G, Reiser, M, Elter, T, Eichhorst, B, Pallasch, C, Hallek, M, Borchmann, P, Hacker, U, Schinkel, S, Wieker, K, Sökler, M, Wolf, Hh, Eucker, J, Staib, P, Schlegel, F, Kropff, M, Kahl, C, Hess, G, Beck, J, Wölfel, T, Bokemeyer, C, Schilling, G, Dierlamm, J, Schüler, F, Busemann, C, Dölken, G, Trendelenburg, Tk, Bühler, A, Stilgenbauer, S, Viardot, A, Greiner, J, Zenz, T, Gaidzik, V, Langer, C, Döhner, H, Werner, I, Dienst, A, Habersang, K, Härtel, N, Leitner, A, Kehrer, G, Middeke, H, Heinisch, K, Adorf, D, Ismer, B, Hering Schubert, C, Jäckle, J, Aulmann, C, Söllner, S, Majunke, P, Fuss, H, Käfer, G, Potenberg, J, Dietrich, G, Hartung, E, Pronath, A, Riedhammer, Fj, Zehrfeld, T, Prümmer, O, Gatter, J, Meier, A, Wattad, M, Heit, W, Sauer, I, Hilgers, K, Geissler, M, Bauer, J, Stein, W, Voigtmann, R, Natt, F, Nickelsen, M, Zeis, M, Schmitz, N, Lange, E, Stoltefuss, A, Schubert, J, Dürk, Ha, Kloke, O, Fauser, A, Roemer, E, Kraut, L, Musch, E, Kohl, S, Link, H, Kirsch, Jf, Schatz, M, Mezger, J, Kempf, B, Heil, G, Derigs, Hg, Roll, C, Kettner, E, Dübbers, Hw, Lutz, L, Hentrich, M, Hoffmann, U, Ibe, M, Falge, C, Schäfer Eckart, K, Rothmann, F, Raghavachar, A, Beckmann, K, Behringer, D, Stauder, H, Hempfling, C, Matzdorff, A, Hähling, D, Kaesberger, Kj, Mück, R, Waladkhani, Ar, Clemens, M, Kraft, J, Ehlert, T, N. N., Schloen, A, Sandritter, B, Scholz, Diekmann, C, Pflüger, Kh, Hausner, G, Fetscher, S, Aulitzky, W, Brugger, W, Frickhofen, N, Fuhr, Lange, C, Lambertz, H, Schulz, L, Schmier, M, Bentz, M, Tauchmann, Gm, Schmidt, M, Meiler, J, Sandmann, M, Kürschner, D, Maier Bay, B, Lindemann, W, Diers, J, Riemeier Sievers, C, Daun, M, Mergenthaler, Hg, Hiller, S, Schirmer, V, Kirchner, H, Langer, W, Günther, B, Gassmann, W, Franke, K, Burghardt, F, Abele, U, Celikel Becker, D, von Weikersthal LF, Brög, G, Hauch, U, Heinrich, B, Brudler, O, Häcker, B, Eckart, Mj, Bolouri, H, Göttler, B, Kindler, M, Zuchold, K, Strohbach, F, Plingen, Ml, Seibt Jung, H, Kirsch, A, Herrenberger, J, Doering, G, von Grünhagen, U, Franke, H, Weniger, J, Kerzel, W, Schmalfeld, M, Rohrberg, R, Hurtz, Hj, Gehbauer, G, Hahnfeld, S, Vehling Kaiser, U, Abenhardt, W, Bosse, D, Böning, L, Schmidt, B, Schick, Hd, Jacobs, G, Stauch, M, Hoffmann, R, Müller, S, Hahn, M, Freier, W, Dietzfelbinger, H, Rassmann, I, Söling, U, Siehl, S, Rudolph, R, Weinert, R, Sauer, A, Meyer, B, Eschenburg, H, Schadeck Gressel, C, Grabenhorst, U, Perker, M, Otremba, B, Reschke, D, Hinrichs, Hf, Zirpel, I, Höring, E, Respondek, M, Köppler, H, Heymanns, J, Weide, R, Hünermund, K, Thiel, C, Reiber, T, Spohn, C, Springer, G, Fiechtner, H, Hübner, A, Kurschel, E, Weiss, J, Schlag, R, Schäfer, E, Hartwich, G, Schmitz, S, Steinmetz, T, Kim, Ts, Lerchenmüller, C, Wehmeyer, J, Laubenstein, Hp, Rendenbach, B, Lebahn, H, Kröning, H, Uhle, R, Balló, H, Gaede, B, Zumbrink, S, Eckert, R, Kamp, T, Reimann, B, Burkhard, O, Mittermüller, J, Hansen, R, Hitz, H, Schliesser, G, Schmitt, Hr, Forstbauer, H, Grundeis, M, Schulze, M, Baldus, M, Lakner, V, Haen, M, Müller, C, Dörfel, S, Göhler, T, Welslau, M, Achtzehn, V, Culmann, H, Gerhardt, S, Ulshöfer, T, Koschuth, A, Schmidt, P, Müller, L, Schneider, M, Koniczek, K, Porowski, P, Glados, M, Knoblich, J, Ben Yehuda, D, Jäger, U, Gaiger, A, Schwarzmeier, J, Nösslinger, T, Smith, M, Patton, N, Gibbons, S, Bouabdallah, R, Gandhi, M, Marlton, P, Mills, T, Angelucci, E, Sorano, Gg, Casula, P, Berneman, Z, Kohser, P, Hudcova Burgetova, A, Machová, R, Papajik, T, Kubová, Z, Fineman, R, Mayer, J, Doubek, M, Brychtova, Y, Ciceri, F, Caligaris Cappio, F, Crocchiolo, R, Dauriac, C, Bernard, M, Escoffre Barbe, M, Lamy, T, Zikesova, E, Karban, J, Salkova, J, Trnený, M, Pytlik, R, Tiley, C, Forsyth, C, Vokurka, S, Koza, V, Van Hoof, A, Selleslag, D, Sebban, C, Baker, B, Belada, D, Jebavy, L, Smolej, L, Pavel, Z, Di Ianni, M, Castaigne, S, Del Poeta, G, Amadori, S, Catalano, J, Ganju, V, Hertzberg, M, Laurenti, L, Dalseg, Am, Bron, D, Morton, J, Durrant, S, Casado, Lf, Theunissen, K, Atias, D, Berkhan, L, Seymour, J, Wolf, M, Bosly, A, Osma Cordoba MM, Portois, C, Jaubert, J, Ferrant, A, Lambert, C, Maerevoet, E, Van den Neste, E, Gadeberg, O, Carney, B, Cannell, P, Eghbali, H, Legouffe, E, Bordessoule, D, Chaury, M, Moreau, S, Pierri, I, Gobbi, M, Berrebi, A, Lishner, M, Yerushazim, R, Yermiaku, T, Kosolov, V, Ambrosetti, Achille, Andreoli, Al, Huguet, F, Laurent, G, Orsucci, L, Forconi, F, Musuraca, G, Zinzani, Pl, Loscertales, J, Mcquillan, A, Cordingley, F, Leahy, M, Cazin, B, Taylor, Mulligan, S, Herbrecht, Cull, G, Seldon, M, Rowlings, P, Ludwig, H, Zojer, N, Solal Céligny, P, Pomponi, F, Savdkova, L, Kozák, T, Christiansen, I, Pérez, I, Campbell, P, Canales Albendea, M, De Paz, R, Arthur, C, Gisselbrecht, C., Eichhorst B.F., Fischer K., Fink A.M., Elter T., Wendtner C.M., Goede V., Bergmann M., Stilgenbauer S., Hopfinger G., Ritgen M., Bahlo J., Busch R., Hallek M., and Zinzani P.L.

Subjects
Male, medicine.medical_specialty, Cyclophosphamide, Chronic lymphocytic leukemia, Immunology, Medizin, Antineoplastic Combined Chemotherapy Protocols, Blood Cell Count, Disease Progression, Disease-Free Survival, Female, Follow-Up Studies, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Middle Aged, Prognosis, Recurrence, Remission Induction, Tomography, X-Ray Computed, Physical examination, Biochemistry, Chemoimmunotherapy, medicine, Chronic, Tomography, Leukemia, medicine.diagnostic_test, business.industry, B-Cell, Cancer, Cell Biology, Hematology, medicine.disease, Lymphocytic, imaging techniques, X-Ray Computed, Fludarabine, Surgery, chronic lymphocytic leukemia, Radiology, business, Progressive disease, medicine.drug
Abstract

The clinical value of imaging is well established for the follow-up of many lymphoid malignancies but not for chronic lymphocytic leukemia (CLL). A meta-analysis was performed with the dataset of 3 German CLL Study Group phase 3 trials (CLL4, CLL5, and CLL8) that included 1372 patients receiving first-line therapy for CLL. Response as well as progression during follow-up was reassessed according to the National Cancer Institute Working Group1996 criteria. A total of 481 events were counted as progressive disease during treatment or follow-up. Of these, 372 progressions (77%) were detected by clinical symptoms or blood counts. Computed tomography (CT) scans or ultrasound were relevant in 44 and 29 cases (9% and 6%), respectively. The decision for relapse treatment was determined by CT scan or ultrasound results in only 2 of 176 patients (1%). CT scan results had an impact on the prognosis of patients in complete remission only after the administration of conventional chemotherapy but not after chemoimmunotherapy. In conclusion, physical examination and blood count remain the methods of choice for staging and clinical follow-up of patients with CLL as recommended by the International Workshop on Chronic Lymphocytic Leukemia 2008 guidelines. These trials are registered at http://www.isrctn.org as ISRCTN 75653261 and ISRCTN 36294212 and at http://www.clinicaltrials.gov as NCT00281918.

Published
2011

22. Optical bench development for LISA

Author

Bogenstahl, J., primary, Diekmann, C., primary, Fitzsimons, E. D., primary, Fleddermann, R., primary, Granova, E., primary, Killow, C. J., primary, Pijnenburg, J., primary, Robertson, D. I., primary, Shoda, A., primary, Sohmer, A., primary, Tröbs, M., primary, Ward, H., primary, Weise, D., primary, d'Arcio, L., primary, Dehne, M., primary, Heinzel, G., primary, Hogenhuis, H., primary, Perreur-Lloyd, M., primary, Taylor, A., primary, and Wanner, G., primary

Published
2017
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23. Design and construction of a telescope simulator for LISA optical bench testing

Author

Diekmann, C., primary, Hennig, J. S., primary, Hey, F. G., primary, Perreur-Lloyd, M., primary, Robertson, D. I., primary, Taylor, A., primary, Weise, D., primary, Fitzsimons, E. D., primary, Lieser, M., primary, Bogenstahl, J., primary, Tröbs, M., primary, d’Arcio, L., primary, Killow, C. J., primary, Lucarelli, Stefano, primary, Pijnenburg, J., primary, Ward, H., primary, Heinzel, G., primary, and Danzmann, Karsten, primary

Published
2017
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24. Optical bench of the laser ranging interferometer on grace follow-on

Author

Nicklaus, K., primary, Baatzsch, A., primary, Diekmann, C., primary, Gilles, F., primary, Zender, B., primary, Sheard, B., primary, Heinzel, G., primary, Herding, M., primary, Dehne, M., primary, Voss, K., primary, Guenther, B., primary, Böhme, S., primary, Mueller, V., primary, Schuetze, D., primary, and Stede, G., primary

Published
2017
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26. Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy

Author

Haaß, Wiltrud, Kleiner, Helga, Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung, Morgner, A., Herbst, R., Matek, W., Lamberti, C., Zöller, T., Koch, B., Marth, T., Henzel, A., Wagner, S., Woska, E., German CML Study Group, Neumann, F., Hoffknecht, M. M., Illmer, T., Wolf, T., Ehninger, G., Kiani, A., Platzbecker, U., Aul, C., Badrakhan, C. D., Giagounidis, A., Wernli, M., Flaßhove, M., Henneke, F., Moritz, T., Simon, M., Müller, L. L., Janz, R., Eckart, M., Häcker, B., Rech, D., Mackensen, A., Bargetzi, M., Krause, S. W., Staib, P., Schlegel, F., Wätzig, K., Rudolph, R., Wattad, M., Baur, F. K., Heit, W., Beelen, D. W., Hüttmann, A., Fischer von Weikersthal, L., Novotny, J., Trenschel, R., Lindemann, A., Linck, D., Jäger, E., Al-Batran, Salah-Eddin, Ottmann, O. G., Serve, H., Reiber, T., Semsek, D., Gro, V., Waller, C., Kühnemund, A., Hoeffkes, H. G., Lambertz, H., Schulz, L., Tajrobehkar, K., Mittermüller, J., Rummel, M. J., Burchardt, A., Pralle, H., Müller, S., Runde, V., Klei, M., Westheider, J., Hoyer, A., Tessen, H. W., Hesse, A., Trümper, L., Binder, C., Schmidt, C. A., Hirt, C., Hahn, M., Sieber, M., Eschenburg, H., Wilhelm, S., Depenbusch, R., Rösel, S., Eimermacher, H., Spohn, C., Moeller, R., Schmitz, N., Nickelsen, M., Schlimok, G., Engel, E., Haatanen, T., Hollburg, W., Platz, D., Köster, H., Bokemeyer, C., Schafhausen, P., Grote-Metke, A., Bechtel, B., Hemeier, M., Reichert, D., Sosada, M., Ganser, A., Schlegelberger, B., Ho, A. D., Rohlfing, S., Dengler, J., Petersen, V., Porowski, P., Hahn, L., Dietzfelbinger, H., Weiß, Christel, Janssen, J., Gröschel, W., Bartholomäus, A., Pfreundschuh, M., Kemmerling, M., Hansen, R., Reeb, M., Link, H., Mahlmann, S., Mezger, J., Schatz, M., Furkert, J., Schmier, M., Gatter, J., Neumann, S., Heymanns, J., Steinmetz, H. T., Schmitz, S., Scheid, C., Planker, M., Frieling, T., Lollert, A., Mandel, T., Neise, M., Schröder, M., Greif, D., Kempf, B., März, W., Kremers, S., Müller, L., Hartmann, F., Heil, G., Goldmann, B., Majunke, P. J., Heinkele, P., Gregor, M., Theobald, M., Fischer, T., Thomas, S., Hensel, M., Plöger, C., Schuster, D., Brust, J., Hieber, U., Paliege, R., Hehlmann, R., Neubauer, A., Burchert, A., Graeven, U., Lange, C., Schmidt, G., Völkl, S., Schmidt, B., Hitz, H., Spiekermann, K., Reichert, P., Hiddemann, W., Haferlach, T., Haferlach, C., Schnittger, S., Stötzer, O., Scheidegger, C., Fischer, C., Berdel, W. E., Koppele, A., Hebart, H., Fuss, H., Snaga, A., Schmidt, P., Hoffmann, R., Reschke, D., Zirpel, I., Sauer, M., Lenk, G., Theilmann, L., Sandritter, B., Neben, K., Schenk, M., Dengler, R., Herr, W., Krause, S., Braun, B., Günther, E., Wacker, A., Pihusch, R., Baldus, M., Matzdorff, A., Staiger, H. J., Pollmeier, G., Grimminger, W., Geer, T., Schanz, S., Jür, C., Gassmann, W., Seitz, K., Kaesberger, J., Mück, R., Heim, D., Illerhaus, G., Denzlinger, C., Fiechtner, H., Springer, G., Hoffmann, D., Jacki, S. H., Kanz, L., Bross-Bach, U., Döhner, H., Stegelmann, F., Haferlach, Claudia, Gratwohl, A., Kalhori, N., Langer, W., Nusch, A., Wei, J., Kamp, T., Schadeck-Gressel, C., Schwerdtfeger, R., Josten, K. M., Klein, O., Fett, W., Tichelli, A., Strotkötter, H., Maintz, C., Groschek, M., Schlag, R., Elsel, W., Schüler, F., Dölken, G., Lindemann, H. W., Wolf, H. H., Schmoll, H. J., Korsten, S., Braumann, D., Hoelzer, P., Kleeberg, U., Hossfeld, D., Lange, E., Schubert, J., Weischer, H., Dürk, H. A., Kirchner, H. H., Bu, E C., Henesser, D., Sievers, B., Freier, W., Kaiser, U., Peest, D., Römer, E., Hermann, T., Fauser, A., Valverde, M. L., Menzel, J., Kemper, J., le Coutre, P., Hochhaus, A., La Rosée, P., Bentz, M., Prümmer, O., Kneba, M., Strack, U., Schoch, R., Severin, K., Stauch, M., Arnold, R., Karbach, U., Vehling-Kaiser, U., Köchling, G., Wei, U., Middeke, H., Neuhaus, T., Martin, H., Fetscher, S., Schmielau, J., Kämpfe, D., Ludwig, W. D., Uppenkamp, M., Wei, B., Thum, P., Wuillemin, W., Hofmann, W. K., Griesshammer, M., Tischler, H. J., Becker, M., Hanfstein, B., Müller, M., Ratei, R., Saußele, S., Lunscken, C., Kolb, H. J., Lutz, L., Hentrich, M., Nerl, C., Wendtner, C., Ladda, E., Gnad, M., Teutsch, C., Suna, H., Schmidt, E., Koschmieder, S., Falge, C., Wandt, H., Wilhelm, M., Köhne, C. H., Schweiger, C., Müller-Naendrup, C., Frühauf, S., Ludwig, F., Ranft, K., Dencausse, Y., Baake, G., Ritter, P. R., Kloke, O., Göttler, B., Schick, H. D., Schlegelberger, Brigitte, Urmersbach, A., Weidenhöfer, S., Weidinger, P., Wacker, D., Wehmeyer, J., Kreuser, E. D., Schlenska-Lange, A., Edinger, R., Andreesen, R., Wehmeier, A., Stahlhut, K., Blau, I., Käfer, G., Cerny, T., Hess, U., Priebe-Richter, C., Stange-Budumlu, O., Demandt, M., Freunek, G., Heidemann, E., Schleicher, J., Mergenthaler, H. G., Ihle, H., Boewer, C., Zeller, C., Laubenstein, H. P., Rendenbach, B., Clemens, M., Waladkhani, A. R., Forstbauer, H., Müller, F., Brettner, S., Raghavachar, A., Sperling, C., Kunzmann, V., Goebeler, M. E., Gmür, J., Schelenz, C., Koschuth, A., Kingreen, D., Heßling, J., Derwahl, K. M., Oldenkott, B., Müller, Martin C., Englisch, H. J., Thiel, E., Burmeister, T., Notter, M., de Wit, M., Rothaug, W., Büschel, G., Beyer, J., Dahmen, E., Hehlmann, Rüdiger, Biaggi, C., Lämmle, B., Friess, D., Baerlocher, G., Oppliger Leibundgut, E., Tobler, A., Just, M., Schäfer, E., Behringer, D., Brandt, M., Hofmann, Wolf-Karsten, Schmiegel, W., Vaupel, H. A., Verbeek, W., Ko, Y. D., Sauerbruch, T., Hahn-Ast, C., Janzen, V., Schmidt-Wolf, Ingo G. H., Trenn, G., Fabarius, Alice, van der Linde, M., Pommerien, W., Fritz, L., Krauter, J., Lordick, F., Fritsch, G., Pflüger, K. H., Diekmann, C., Kullmer, J., Doering, G., Seifarth, Wolfgang, Munzinger, H., Hertenstein, B., Peyn, A., Mayer, J., Zácková, D., Kujickova, J., Stier, S., Wejda, B., Möller-Faßbender, F., and Hänel, M.

Subjects
Adult, Aged, 80 and over, Chromosome Aberrations, Adolescent, Fusion Proteins, bcr-abl, Antineoplastic Agents, Chromosome Breakage, Middle Aged, Clonal Evolution, Young Adult, hemic and lymphatic diseases, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Proteolysis, Imatinib Mesylate, Humans, Blast Crisis, Separase, Research Article, Aged
Abstract

PLoS ONE 10(6), e0129648 (2015). doi:10.1371/journal.pone.0129648, Published by PLoS, Lawrence, Kan.

Published
2015
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27. OPTICAL BENCH DEVELOPMENT FOR LISA.

Author

d'Arcio, L., Bogenstahl, J., Dehne, M., Diekmann, C., Fitzsimons, E. D., Fleddermann, R., Granova, E., Heinzel, G., Hogenhuis, H., Killow, C. J., Perreur-Lloyd, M., Pijnenburg, J., Robertson, D. I., Shoda, A., Sohmer, A., Taylor, A., Tröbs, M., Wanner, G., Ward, H., and Weise, D.

Published
2017
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30. Comparison of 18F-GE-180 and dynamic 18F-FET PET in high grade glioma: a double-tracer pilot study.

Author

Unterrainer, Marcus, Fleischmann, D. F., Diekmann, C., Vomacka, L., Lindner, S., Vettermann, F., Brendel, M., Wenter, V., Ertl-Wagner, B., Herms, J., Wetzel, C., Rupprecht, R., Tonn, J. C., Belka, C., Bartenstein, P., Niyazi, M., and Albert, Nathalie L.

Subjects
GLIOMAS, POSITRON emission tomography, MAGNETIC resonance imaging, NERVOUS system tumors, DIAGNOSTIC imaging
Abstract

Background: PET represents a valuable tool for glioma imaging. In addition to amino acid tracers such as 18F-FET, PET targeting the 18-kDa mitochondrial translocator-protein (TSPO) is of high interest for high-grade glioma (HGG) imaging due to its upregulation in HGG cells. 18F-GE-180, a novel TSPO ligand, has shown a high target-to-background contrast in HGG. Therefore, we intra-individually compared its uptake characteristics to dynamic 18F-FET PET and contrast-enhanced MRI in patients with HGG.Methods: Twenty HGG patients (nine IDH-wildtype, 11 IDH-mutant) at initial diagnosis (n = 8) or recurrence (n = 12) were consecutively included and underwent 18F-GE-180 PET, dynamic 18F-FET PET, and MRI. The maximal tumour-to-background ratios (TBRmax) and biological tumour volumes (BTV) were evaluated in 18F-GE-180 and 18F-FET PET. Dynamic 18F-FET PET analysis included the evaluation of minimal time-to-peak (TTPmin). In MRI, the volume of contrast-enhancement was delineated (VOLCE). Volumes were spatially correlated using the Sørensen-Dice coefficient.Results: The median TBRmax tended to be higher in 18F-GE-180 PET compared to 18F-FET PET [4.58 (2.33-8.95) vs 3.89 (1.56-7.15); p = 0.062] in the overall group. In subgroup analyses, IDH-wildtype gliomas showed a significantly higher median TBRmax in 18F-GE-180 PET compared to 18F-FET PET [5.45 (2.56-8.95) vs 4.06 (1.56-4.48); p = 0.008]; by contrast, no significant difference was observed in IDH-mutant gliomas [3.97 (2.33-6.81) vs 3.79 (2.01-7.15) p = 1.000]. Only 5/20 cases showed higher TBRmax in 18F-FET PET compared to 18F-GE-180 PET, all of them being IDH-mutant gliomas. No parameter in 18F-GE-180 PET correlated with TTPmin (p > 0.05 each). There was a tendency towards higher median BTVGE-180 [32.1 (0.4-236.0) ml] compared to BTVFET [19.3 (0.7-150.2) ml; p = 0.062] with a moderate spatial overlap [median Sørensen-Dice coefficient 0.55 (0.07-0.85)]. In MRI, median VOLCE [9.7 (0.1-72.5) ml] was significantly smaller than both BTVFET and BTVGE180 (p < 0.001 each), leading to a poor spatial correlation with BTVGE-180 [0.29 (0.01-0.48)] and BTVFET [0.38 (0.01-0.68)].Conclusion: PET with 18F-GE-180 and 18F-FET provides differing imaging information in HGG dependent on the IDH-mutational status, with diverging spatial overlap and vast exceedance of contrast-enhancement in MRI. Combined PET imaging might reveal new insights regarding non-invasive characterization of tumour heterogeneity and might influence patients' management. [ABSTRACT FROM AUTHOR]

Published
2019
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32. Über den Stellenwert der Rhinomanometrie bei Kindern

Author

Rose-Diekmann, C, Welkoborsky, HJ, and Recht, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Rhinomanometrie ist ein Messverfahren zur Bestimmung des nasalen Volumenstroms und des nasalen Widerstandes. Zur Objektivierung einer nasalen Obstruktion und vor nasenchirurgischen Eingriffen stellt die Rhinomanometrie vor und nach Gabe von abschwellenden Medikamenten einen unverzichtbaren[for full text, please go to the a.m. URL], 85. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Published
2014
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33. LISA Optical Bench Testing

Author

Troebs, M., D Arcio, L., Barke, S., Bogenstahl, J., Diekmann, C., Fitzsimons, E. D., Oliver Gerberding, Hennig, J. S., Hey, F. G., Hogenhuis, H., Killow, C. J., Lieser, M., Lucarelli, S., Nikolov, S., Perreur-Lloyd, M., Pijnenburg, J., Robertson, D. I., Sohmer, A., Taylor, A., Ward, H., Weise, D., Heinzel, G., and Danzmann, K.

Subjects
Astrophysics::Instrumentation and Methods for Astrophysics
Abstract

Each LISA satellite carries optical benches, one for each test mass, that measure the distance to the local test mass and to the remote optical bench on the distant satellite. Currently, an elegant bread board of the optical bench is developed for the European Space Agency (ESA) by EADS Astrium, TNO Science and Technology, University of Glasgow and the Albert Einstein Institute. To test the optical bench the two interferometers mentioned above must be completed by an external simulator, the test mass and telescope simulator. We give an overview of the simulator layout and performance predictions.

Published
2013

34. Driving performance in patients with chronic obstructive pulmonary disease

Author

Orth M, Diekmann C, Boris Suchan, Hw, Duchna, Widdig W, Schultze-Werninghaus G, Rasche K, and Kotterba S

Subjects
Male, Oxygen, Automobile Driving, Pulmonary Disease, Chronic Obstructive, Polysomnography, Linear Models, Humans, Female, Blood Gas Analysis, Middle Aged, Psychomotor Performance, Respiratory Function Tests
Abstract

Patients with chronic obstructive pulmonary disease (COPD) present with impairments of their cognitive performance. It is still unknown whether cognitive deficits influence driving abilities in patients with COPD. The present study investigates driving performance in patients with COPD and healthy controls. Driving simulation was performed in 17 patients with COPD and 10 healthy controls. Patients with COPD demonstrated significantly worse results in terms of accident frequency in the simulated driving situation. No correlations existed between the severity of disease, assessed from the polysomnographical findings (e.g., lung function, blood gas analysis, sleep disturbance, nocturnal ventilation, and oxygen saturation), and driving performance. We conclude that impairments of driving performance in patients with COPD cannot be predicted on the basis of the severity of the disease. The impairment of driving performance in the simulated driving situation in COPD patients may have crucial consequences for driving licensing in these patients.

Published
2008

36. Novel delivery system enhances efficacy of antiretroviral therapy in animal model for HIV-1 encephalitis

Author

Kabanov, A.V., Spitzenberger, T.J., Persidsky, Y., Diekmann, C., Batrakova, E.V., Gendelman, H.E., Heilman, D., and Elmquist, W.F.

Subjects
macromolecular substances, hormones, hormone substitutes, and hormone antagonists
Abstract

Most potent antiretroviral drugs (e.g., HIV-1 protease inhibitors) poorly penetrate the blood-brain barrier. Brain distribution can be limited by the efflux transporter, P-glycoprotein (P-gp). The ability of a novel drug delivery system (block co-polymer P85) that inhibits P-gp, to increase the efficacy of antiretroviral drugs in brain was examined using a severe combined immunodeficiency (SCID) mouse model of HIV-1 encephalitis (HIVE). Severe combined immunodeficiency mice inoculated with HIV-1 infected human monocyte-derived macrophages (MDM) into the basal ganglia were treated with P85, antiretroviral therapy (ART) (zidovudine, lamivudine and nelfinavir (NEL)), or P85 and ART. Mice were killed on days 7 and 14, and brains were evaluated for levels of viral infection. Antiviral effects of NEL, P85, or their combination were evaluated in vitro using HIV-1 infected MDM and showed antiretroviral effects of P85 alone. In SCID mice injected with virus-infected MDM, the combination of ART-P85 and ART alone showed a significant decrease of HIV-1 p24 expressing MDM (25% and 33% of controls, respectively) at day 7 while P85 alone group was not different from control. At day 14, all treatment groups showed a significant decrease in percentage of HIV-1 infected MDM as compared with control. P85 alone and combined ART-P85 groups showed the most significant reduction in percentage of HIV-1 p24 expressing MDM (8% to 22% of control) that were superior to the ART alone group (38% of control). Our findings indicate major antiretroviral effects of P85 and enhanced in vivo efficacy of antiretroviral drugs when combined with P85 in a SCID mouse model of HIVE.

Published
2007
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38. Optical bench development for LISA

Author

Kadowaki, Naoto, d'Arcio, L., Bogenstahl, J., Dehne, M., Diekmann, C., Fitzsimons, E. D., Fleddermann, R., Granova, E., Heinzel, G., Hogenhuis, H., Killow, C. J., Perreur-Lloyd, M., Pijnenburg, J., Robertson, D. I., Shoda, A., Sohmer, A., Taylor, A., Tröbs, M., Wanner, G., Ward, H., and Weise, D.

Published
2017
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43. Peritoneal dialysis

Author

Kunze, R., primary, Witt, S., additional, Vienken, J., additional, Rie, K., additional, Masayoshi, N., additional, Aritoshi, K., additional, Yoshinaga, O., additional, Yukiko, H., additional, Takahiro, K., additional, Hiroshi, N., additional, Takeshi, N., additional, Aoki, S., additional, Makino, J., additional, Noguchi, M., additional, Yamasaki, F., additional, Toda, S., additional, Santiago, J., additional, Caparros, G., additional, Vozmediano, C., additional, Molina, F., additional, Javier, L., additional, Sara, A., additional, Minerva, A., additional, Romera, A., additional, Kihm, L., additional, Diekmann, C., additional, Seckinger, J., additional, Sommerer, C., additional, Morath, C., additional, Zeier, M., additional, Schwenger, V., additional, Teixeira, L., additional, Rodrigues, A., additional, Carvalho, M. J., additional, Cabrita, A., additional, and Mendonca, D., additional

Published
2011
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